SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_K_TFPK202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 LEU A 142
PHE A  86
ILE A  18
ASP A 145
SER A 130
 None
 1.11A 3ko0K-1ag9A:
undetectable
3ko0L-1ag9A:
undetectable
3ko0S-1ag9A:
undetectable
3ko0T-1ag9A:
undetectable		 3ko0K-1ag9A:
22.70
3ko0L-1ag9A:
22.70
3ko0S-1ag9A:
22.70
3ko0T-1ag9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czk FLAVODOXIN

(Synechococcus
elongatus) 		PF00258
(Flavodoxin_1) 		5 LEU A 141
PHE A  86
ILE A  17
ASP A 144
SER A 130
 None
 1.12A 3ko0K-1czkA:
undetectable
3ko0L-1czkA:
undetectable
3ko0S-1czkA:
undetectable
3ko0T-1czkA:
undetectable		 3ko0K-1czkA:
21.02
3ko0L-1czkA:
21.02
3ko0S-1czkA:
21.02
3ko0T-1czkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		5 LEU A 169
ILE A 135
LEU A 131
ASP A 130
ASP A  36
 None
 1.17A 3ko0K-1hlgA:
undetectable
3ko0L-1hlgA:
undetectable
3ko0S-1hlgA:
undetectable
3ko0T-1hlgA:
undetectable		 3ko0K-1hlgA:
12.84
3ko0L-1hlgA:
12.84
3ko0S-1hlgA:
12.84
3ko0T-1hlgA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		5 LEU A 339
SER A 340
PHE A 344
GLU A 343
ASP A 252
 None
 1.08A 3ko0K-1ij5A:
7.0
3ko0L-1ij5A:
7.3
3ko0S-1ij5A:
6.9
3ko0T-1ij5A:
7.3		 3ko0K-1ij5A:
17.12
3ko0L-1ij5A:
17.12
3ko0S-1ij5A:
17.12
3ko0T-1ij5A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn1 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Haemophilus
influenzae) 		PF02542
(YgbB) 		5 LEU A 121
PHE A  82
ILE A  49
LEU A  45
ASP A  73
 None
 1.19A 3ko0K-1jn1A:
undetectable
3ko0L-1jn1A:
undetectable
3ko0S-1jn1A:
undetectable
3ko0T-1jn1A:
undetectable		 3ko0K-1jn1A:
20.67
3ko0L-1jn1A:
20.67
3ko0S-1jn1A:
20.67
3ko0T-1jn1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 PHE A  92
ASP A  87
PHE A 110
ASP A 137
SER A 152
 None
MFU  A 501 (-3.1A)
None
MN  A 245 ( 2.7A)
MN  A 245 ( 4.3A)
 1.22A 3ko0K-1jxnA:
undetectable
3ko0L-1jxnA:
undetectable
3ko0S-1jxnA:
undetectable
3ko0T-1jxnA:
undetectable		 3ko0K-1jxnA:
21.25
3ko0L-1jxnA:
21.25
3ko0S-1jxnA:
21.25
3ko0T-1jxnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 LEU L 408
PHE L 502
ILE L 211
PHE L 497
LEU L 472
 None
 1.20A 3ko0K-1kfuL:
0.0
3ko0L-1kfuL:
6.6
3ko0S-1kfuL:
0.0
3ko0T-1kfuL:
3.8		 3ko0K-1kfuL:
11.01
3ko0L-1kfuL:
11.01
3ko0S-1kfuL:
11.01
3ko0T-1kfuL:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 LEU A 436
SER A 486
ILE A 423
ASP A 439
ASP A 482
 None
 1.13A 3ko0K-1pz3A:
undetectable
3ko0L-1pz3A:
undetectable
3ko0S-1pz3A:
undetectable
3ko0T-1pz3A:
undetectable		 3ko0K-1pz3A:
12.17
3ko0L-1pz3A:
12.17
3ko0S-1pz3A:
12.17
3ko0T-1pz3A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A 296
SER A 297
PHE A 301
ILE A 304
LEU A 325
 None
 1.14A 3ko0K-1pztA:
undetectable
3ko0L-1pztA:
undetectable
3ko0S-1pztA:
undetectable
3ko0T-1pztA:
undetectable		 3ko0K-1pztA:
17.80
3ko0L-1pztA:
17.80
3ko0S-1pztA:
17.80
3ko0T-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A  32
PHE A  29
ILE A 108
LEU A  64
ASP A  24
 None
 1.21A 3ko0K-1q3bA:
0.3
3ko0L-1q3bA:
undetectable
3ko0S-1q3bA:
0.8
3ko0T-1q3bA:
undetectable		 3ko0K-1q3bA:
17.05
3ko0L-1q3bA:
17.05
3ko0S-1q3bA:
17.05
3ko0T-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		5 LEU A  20
ILE A  35
LEU A  37
ASP A  38
PHE A 205
 None
None
None
ZN  A 900 (-2.6A)
None
 1.14A 3ko0K-1tqxA:
undetectable
3ko0L-1tqxA:
undetectable
3ko0S-1tqxA:
undetectable
3ko0T-1tqxA:
undetectable		 3ko0K-1tqxA:
19.47
3ko0L-1tqxA:
19.47
3ko0S-1tqxA:
19.47
3ko0T-1tqxA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6f GLIA MATURATION
FACTOR, BETA

(Mus musculus) 		PF00241
(Cofilin_ADF) 		5 LEU A  24
PHE A  27
ILE A  38
LEU A  20
ASP A  19
 None
 1.04A 3ko0K-1v6fA:
undetectable
3ko0L-1v6fA:
undetectable
3ko0S-1v6fA:
undetectable
3ko0T-1v6fA:
undetectable		 3ko0K-1v6fA:
20.00
3ko0L-1v6fA:
20.00
3ko0S-1v6fA:
20.00
3ko0T-1v6fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 LEU A 243
LEU A 110
ASP A 111
ASP A 277
SER A 280
 None
 1.09A 3ko0K-1vp4A:
0.0
3ko0L-1vp4A:
undetectable
3ko0S-1vp4A:
0.0
3ko0T-1vp4A:
undetectable		 3ko0K-1vp4A:
13.44
3ko0L-1vp4A:
13.44
3ko0S-1vp4A:
13.44
3ko0T-1vp4A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)

(Sulfurisphaera
tokodaii) 		PF01923
(Cob_adeno_trans) 		5 LEU A  68
SER A  69
ILE A  64
LEU A  31
ASP A  32
 None
None
None
POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
 1.10A 3ko0K-1wozA:
0.9
3ko0L-1wozA:
1.4
3ko0S-1wozA:
0.9
3ko0T-1wozA:
undetectable		 3ko0K-1wozA:
20.57
3ko0L-1wozA:
20.57
3ko0S-1wozA:
20.57
3ko0T-1wozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 285
SER A 266
ILE A 301
PHE A 224
LEU A 303
 None
 1.12A 3ko0K-1x9eA:
0.0
3ko0L-1x9eA:
undetectable
3ko0S-1x9eA:
0.0
3ko0T-1x9eA:
undetectable		 3ko0K-1x9eA:
14.44
3ko0L-1x9eA:
14.44
3ko0S-1x9eA:
14.44
3ko0T-1x9eA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 177
SER A 178
PHE A 182
ILE A 185
GLU A 181
 None
 1.22A 3ko0K-1ykwA:
undetectable
3ko0L-1ykwA:
undetectable
3ko0S-1ykwA:
undetectable
3ko0T-1ykwA:
undetectable		 3ko0K-1ykwA:
12.47
3ko0L-1ykwA:
12.47
3ko0S-1ykwA:
12.47
3ko0T-1ykwA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbp HYPOTHETICAL PROTEIN
VPA1032

(Vibrio
parahaemolyticus) 		PF07024
(ImpE) 		5 LEU A 104
SER A 106
PHE A 107
ILE A 126
LEU A 100
 None
 1.06A 3ko0K-1zbpA:
undetectable
3ko0L-1zbpA:
undetectable
3ko0S-1zbpA:
undetectable
3ko0T-1zbpA:
undetectable		 3ko0K-1zbpA:
17.49
3ko0L-1zbpA:
17.49
3ko0S-1zbpA:
17.49
3ko0T-1zbpA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 LEU A  25
SER A  24
ILE A  36
CYH A  10
ASP A  13
 None
 1.16A 3ko0K-1zzmA:
0.0
3ko0L-1zzmA:
undetectable
3ko0S-1zzmA:
0.0
3ko0T-1zzmA:
undetectable		 3ko0K-1zzmA:
14.89
3ko0L-1zzmA:
14.89
3ko0S-1zzmA:
14.89
3ko0T-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA) 		5 LEU A 122
ILE A 149
CYH A 153
LEU A 137
SER A 132
 None
 1.15A 3ko0K-2chgA:
2.4
3ko0L-2chgA:
2.4
3ko0S-2chgA:
2.1
3ko0T-2chgA:
undetectable		 3ko0K-2chgA:
23.08
3ko0L-2chgA:
23.08
3ko0S-2chgA:
23.08
3ko0T-2chgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8

(Homo sapiens) 		no annotation 5 LEU A  64
SER A  66
PHE A  65
ILE A  86
LEU A  72
 None
 1.16A 3ko0K-2e8mA:
0.0
3ko0L-2e8mA:
undetectable
3ko0S-2e8mA:
undetectable
3ko0T-2e8mA:
undetectable		 3ko0K-2e8mA:
20.00
3ko0L-2e8mA:
20.00
3ko0S-2e8mA:
20.00
3ko0T-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 LEU A 130
SER A 128
PHE A 129
ILE A 317
LEU A 288
 None
 0.88A 3ko0K-2fqxA:
undetectable
3ko0L-2fqxA:
undetectable
3ko0S-2fqxA:
undetectable
3ko0T-2fqxA:
undetectable		 3ko0K-2fqxA:
13.92
3ko0L-2fqxA:
13.92
3ko0S-2fqxA:
13.92
3ko0T-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 LEU A 156
SER A 157
ILE A 164
GLU A 160
LEU A 134
 None
 1.21A 3ko0K-2ghiA:
undetectable
3ko0L-2ghiA:
undetectable
3ko0S-2ghiA:
undetectable
3ko0T-2ghiA:
undetectable		 3ko0K-2ghiA:
17.14
3ko0L-2ghiA:
17.14
3ko0S-2ghiA:
17.14
3ko0T-2ghiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Mus musculus) 		PF14580
(LRR_9) 		5 LEU A 109
ILE A 100
CYH A 123
LEU A  95
ASP A 119
 None
 1.07A 3ko0K-2jqdA:
undetectable
3ko0L-2jqdA:
undetectable
3ko0S-2jqdA:
undetectable
3ko0T-2jqdA:
undetectable		 3ko0K-2jqdA:
18.39
3ko0L-2jqdA:
18.39
3ko0S-2jqdA:
18.39
3ko0T-2jqdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 910
PHE A 909
ILE A 888
CYH A 892
LEU A 845
 None
 0.98A 3ko0K-2ogvA:
undetectable
3ko0L-2ogvA:
undetectable
3ko0S-2ogvA:
undetectable
3ko0T-2ogvA:
undetectable		 3ko0K-2ogvA:
15.41
3ko0L-2ogvA:
15.41
3ko0S-2ogvA:
15.41
3ko0T-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmu RESPONSE REGULATOR
PHOP

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C) 		5 LEU A 174
SER A 175
PHE A 179
GLU A 178
LEU A 221
 None
 1.23A 3ko0K-2pmuA:
undetectable
3ko0L-2pmuA:
undetectable
3ko0S-2pmuA:
undetectable
3ko0T-2pmuA:
undetectable		 3ko0K-2pmuA:
19.82
3ko0L-2pmuA:
19.82
3ko0S-2pmuA:
19.82
3ko0T-2pmuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 LEU A  82
SER A  84
PHE A  86
LEU A 117
ASP A 257
 None
 1.19A 3ko0K-2q83A:
undetectable
3ko0L-2q83A:
undetectable
3ko0S-2q83A:
undetectable
3ko0T-2q83A:
undetectable		 3ko0K-2q83A:
15.38
3ko0L-2q83A:
15.38
3ko0S-2q83A:
15.38
3ko0T-2q83A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 LEU A 738
ILE A 769
PHE A 705
ASP A 748
PHE A 751
 None
 1.18A 3ko0K-2v26A:
undetectable
3ko0L-2v26A:
undetectable
3ko0S-2v26A:
1.5
3ko0T-2v26A:
undetectable		 3ko0K-2v26A:
9.24
3ko0L-2v26A:
9.24
3ko0S-2v26A:
9.24
3ko0T-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 363
ILE A 398
PHE A 107
ASP A 402
ASP A 141
 None
 1.16A 3ko0K-2wn4A:
undetectable
3ko0L-2wn4A:
undetectable
3ko0S-2wn4A:
undetectable
3ko0T-2wn4A:
undetectable		 3ko0K-2wn4A:
13.10
3ko0L-2wn4A:
13.10
3ko0S-2wn4A:
13.10
3ko0T-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF01590
(GAF) 		5 LEU A 289
ILE A 372
CYH A 408
LEU A 271
PHE A 401
 None
 1.15A 3ko0K-2zmfA:
undetectable
3ko0L-2zmfA:
undetectable
3ko0S-2zmfA:
undetectable
3ko0T-2zmfA:
undetectable		 3ko0K-2zmfA:
17.86
3ko0L-2zmfA:
17.86
3ko0S-2zmfA:
17.86
3ko0T-2zmfA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU B  68
SER B  70
PHE B  71
LEU B 106
PHE B  85
 None
HEM  B 401 ( 3.8A)
None
HEM  B 401 ( 4.5A)
None
 1.20A 3ko0K-3a0gB:
undetectable
3ko0L-3a0gB:
undetectable
3ko0S-3a0gB:
undetectable
3ko0T-3a0gB:
undetectable		 3ko0K-3a0gB:
21.92
3ko0L-3a0gB:
21.92
3ko0S-3a0gB:
21.92
3ko0T-3a0gB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 LEU A 457
ILE A 514
LEU A 523
ASP A 490
SER A 488
 None
 1.13A 3ko0K-3ddnA:
undetectable
3ko0L-3ddnA:
undetectable
3ko0S-3ddnA:
undetectable
3ko0T-3ddnA:
undetectable		 3ko0K-3ddnA:
8.83
3ko0L-3ddnA:
8.83
3ko0S-3ddnA:
8.83
3ko0T-3ddnA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 LEU A 224
SER A 220
ILE A  38
LEU A  19
ASP A  18
 None
 1.22A 3ko0K-3dp9A:
undetectable
3ko0L-3dp9A:
undetectable
3ko0S-3dp9A:
undetectable
3ko0T-3dp9A:
undetectable		 3ko0K-3dp9A:
21.89
3ko0L-3dp9A:
21.89
3ko0S-3dp9A:
21.89
3ko0T-3dp9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 LEU C1434
LEU C1416
ASP C1413
PHE C1450
SER C1402
 None
 1.21A 3ko0K-3dqvC:
undetectable
3ko0L-3dqvC:
undetectable
3ko0S-3dqvC:
undetectable
3ko0T-3dqvC:
undetectable		 3ko0K-3dqvC:
13.84
3ko0L-3dqvC:
13.84
3ko0S-3dqvC:
13.84
3ko0T-3dqvC:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 LEU A 427
PHE A 367
LEU A 338
ASP A 339
SER A 348
 None
 1.13A 3ko0K-3e0lA:
undetectable
3ko0L-3e0lA:
undetectable
3ko0S-3e0lA:
undetectable
3ko0T-3e0lA:
undetectable		 3ko0K-3e0lA:
13.11
3ko0L-3e0lA:
13.11
3ko0S-3e0lA:
13.11
3ko0T-3e0lA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 SER A 171
PHE A 410
ILE A 395
PHE A 298
ASP A 164
 None
 1.16A 3ko0K-3eafA:
undetectable
3ko0L-3eafA:
undetectable
3ko0S-3eafA:
undetectable
3ko0T-3eafA:
undetectable		 3ko0K-3eafA:
12.92
3ko0L-3eafA:
12.92
3ko0S-3eafA:
12.92
3ko0T-3eafA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		5 ILE X 260
GLU X 241
LEU X 262
ASP X 270
SER X 273
 None
 1.15A 3ko0K-3ewbX:
undetectable
3ko0L-3ewbX:
undetectable
3ko0S-3ewbX:
undetectable
3ko0T-3ewbX:
undetectable		 3ko0K-3ewbX:
15.28
3ko0L-3ewbX:
15.28
3ko0S-3ewbX:
15.28
3ko0T-3ewbX:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 LEU A 146
ILE A 122
CYH A 133
PHE A 132
LEU A 154
 None
 1.18A 3ko0K-3fkdA:
undetectable
3ko0L-3fkdA:
undetectable
3ko0S-3fkdA:
undetectable
3ko0T-3fkdA:
undetectable		 3ko0K-3fkdA:
12.82
3ko0L-3fkdA:
12.82
3ko0S-3fkdA:
12.82
3ko0T-3fkdA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		5 LEU A 155
ILE A  18
PHE A 186
PHE A 311
SER A  47
 None
 1.23A 3ko0K-3g68A:
0.6
3ko0L-3g68A:
0.5
3ko0S-3g68A:
0.6
3ko0T-3g68A:
0.5		 3ko0K-3g68A:
14.66
3ko0L-3g68A:
14.66
3ko0S-3g68A:
14.66
3ko0T-3g68A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8w LACTOCOCCAL PROPHAGE
PS3 PROTEIN 05

(Staphylococcus
epidermidis) 		PF13420
(Acetyltransf_4) 		5 LEU A 115
ILE A 103
CYH A  67
PHE A  87
LEU A  69
 None
 1.23A 3ko0K-3g8wA:
undetectable
3ko0L-3g8wA:
undetectable
3ko0S-3g8wA:
undetectable
3ko0T-3g8wA:
undetectable		 3ko0K-3g8wA:
25.00
3ko0L-3g8wA:
25.00
3ko0S-3g8wA:
25.00
3ko0T-3g8wA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 293
SER A 290
ILE A 257
CYH A 259
LEU A 312
 None
 1.13A 3ko0K-3h11A:
undetectable
3ko0L-3h11A:
undetectable
3ko0S-3h11A:
undetectable
3ko0T-3h11A:
undetectable		 3ko0K-3h11A:
15.79
3ko0L-3h11A:
15.79
3ko0S-3h11A:
15.79
3ko0T-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 LEU A 133
SER A 130
ILE A 403
LEU A 380
ASP A 379
 None
 1.03A 3ko0K-3hq2A:
undetectable
3ko0L-3hq2A:
undetectable
3ko0S-3hq2A:
undetectable
3ko0T-3hq2A:
undetectable		 3ko0K-3hq2A:
12.15
3ko0L-3hq2A:
12.15
3ko0S-3hq2A:
12.15
3ko0T-3hq2A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 5 LEU A 181
SER A 178
ILE A  68
PHE A 240
ASP A 172
 None
 1.18A 3ko0K-3hwpA:
undetectable
3ko0L-3hwpA:
undetectable
3ko0S-3hwpA:
undetectable
3ko0T-3hwpA:
undetectable		 3ko0K-3hwpA:
15.77
3ko0L-3hwpA:
15.77
3ko0S-3hwpA:
15.77
3ko0T-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 416
ILE A 408
LEU A 437
ASP A 436
PHE A 381
 None
None
None
NDG  A4701 ( 3.1A)
None
 1.11A 3ko0K-3i2tA:
undetectable
3ko0L-3i2tA:
undetectable
3ko0S-3i2tA:
undetectable
3ko0T-3i2tA:
undetectable		 3ko0K-3i2tA:
11.34
3ko0L-3i2tA:
11.34
3ko0S-3i2tA:
11.34
3ko0T-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 SER A 111
ILE A 307
GLU A 107
LEU A 106
ASP A 105
 None
 1.18A 3ko0K-3ip3A:
undetectable
3ko0L-3ip3A:
undetectable
3ko0S-3ip3A:
undetectable
3ko0T-3ip3A:
undetectable		 3ko0K-3ip3A:
16.94
3ko0L-3ip3A:
16.94
3ko0S-3ip3A:
16.94
3ko0T-3ip3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		5 LEU A 170
PHE A 147
ILE A 103
LEU A  79
ASP A 142
 None
 1.20A 3ko0K-3k4zA:
undetectable
3ko0L-3k4zA:
undetectable
3ko0S-3k4zA:
undetectable
3ko0T-3k4zA:
undetectable		 3ko0K-3k4zA:
16.07
3ko0L-3k4zA:
16.07
3ko0S-3k4zA:
16.07
3ko0T-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kby PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10804
(DUF2538) 		5 SER A 113
PHE A 110
ILE A 109
GLU A 103
ASP A 106
 None
 1.06A 3ko0K-3kbyA:
undetectable
3ko0L-3kbyA:
undetectable
3ko0S-3kbyA:
undetectable
3ko0T-3kbyA:
undetectable		 3ko0K-3kbyA:
21.13
3ko0L-3kbyA:
21.13
3ko0S-3kbyA:
21.13
3ko0T-3kbyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		5 LEU A 289
SER A 285
PHE A 288
ILE A 251
ASP A 229
 None
None
None
None
FE  A 334 (-3.1A)
 1.23A 3ko0K-3ktcA:
undetectable
3ko0L-3ktcA:
undetectable
3ko0S-3ktcA:
undetectable
3ko0T-3ktcA:
undetectable		 3ko0K-3ktcA:
16.22
3ko0L-3ktcA:
16.22
3ko0S-3ktcA:
16.22
3ko0T-3ktcA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4

(Homo sapiens) 		no annotation 5 LEU A 230
SER A 331
ILE A 254
PHE A 251
SER A 377
 None
 1.15A 3ko0K-3l15A:
undetectable
3ko0L-3l15A:
undetectable
3ko0S-3l15A:
undetectable
3ko0T-3l15A:
undetectable		 3ko0K-3l15A:
20.36
3ko0L-3l15A:
20.36
3ko0S-3l15A:
20.36
3ko0T-3l15A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 166
SER A 169
PHE A 170
LEU A 272
SER A 203
 None
 1.22A 3ko0K-3mjoA:
1.0
3ko0L-3mjoA:
0.8
3ko0S-3mjoA:
0.7
3ko0T-3mjoA:
0.7		 3ko0K-3mjoA:
17.12
3ko0L-3mjoA:
17.12
3ko0S-3mjoA:
17.12
3ko0T-3mjoA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		5 LEU A 249
PHE A 311
LEU A 172
PHE A  83
ASP A 258
 None
 1.14A 3ko0K-3n8uA:
undetectable
3ko0L-3n8uA:
undetectable
3ko0S-3n8uA:
undetectable
3ko0T-3n8uA:
undetectable		 3ko0K-3n8uA:
14.11
3ko0L-3n8uA:
14.11
3ko0S-3n8uA:
14.11
3ko0T-3n8uA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph2 CYTOCHROME C6

(Phormidium
laminosum) 		PF13442
(Cytochrome_CBB3) 		5 LEU B  37
ILE B  48
LEU B  79
ASP B  80
PHE B  11
 None
HEM  B1087 ( 4.4A)
None
None
None
 1.18A 3ko0K-3ph2B:
undetectable
3ko0L-3ph2B:
undetectable
3ko0S-3ph2B:
undetectable
3ko0T-3ph2B:
undetectable		 3ko0K-3ph2B:
19.00
3ko0L-3ph2B:
19.00
3ko0S-3ph2B:
19.00
3ko0T-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A 310
PHE A 311
ILE A 276
LEU A 107
ASP A 111
 None
 1.06A 3ko0K-3r11A:
undetectable
3ko0L-3r11A:
undetectable
3ko0S-3r11A:
undetectable
3ko0T-3r11A:
undetectable		 3ko0K-3r11A:
12.40
3ko0L-3r11A:
12.40
3ko0S-3r11A:
12.40
3ko0T-3r11A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 203
ILE A 169
LEU A 223
ASP A 222
PHE A 253
 None
 1.17A 3ko0K-3skvA:
undetectable
3ko0L-3skvA:
undetectable
3ko0S-3skvA:
undetectable
3ko0T-3skvA:
undetectable		 3ko0K-3skvA:
14.71
3ko0L-3skvA:
14.71
3ko0S-3skvA:
14.71
3ko0T-3skvA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU A 271
ILE A 279
LEU A 300
PHE A 286
SER A 290
 None
 0.85A 3ko0K-3t6qA:
undetectable
3ko0L-3t6qA:
undetectable
3ko0S-3t6qA:
undetectable
3ko0T-3t6qA:
undetectable		 3ko0K-3t6qA:
10.23
3ko0L-3t6qA:
10.23
3ko0S-3t6qA:
10.23
3ko0T-3t6qA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 LEU A 431
ILE A 262
LEU A 435
ASP A 436
PHE A 777
 None
None
None
None
EDO  A 795 ( 3.6A)
 0.78A 3ko0K-3tbkA:
undetectable
3ko0L-3tbkA:
undetectable
3ko0S-3tbkA:
undetectable
3ko0T-3tbkA:
undetectable		 3ko0K-3tbkA:
10.99
3ko0L-3tbkA:
10.99
3ko0S-3tbkA:
10.99
3ko0T-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 LEU A 324
SER A 321
ILE A 293
LEU A 260
ASP A 132
 None
 1.19A 3ko0K-3uduA:
undetectable
3ko0L-3uduA:
undetectable
3ko0S-3uduA:
undetectable
3ko0T-3uduA:
0.6		 3ko0K-3uduA:
16.22
3ko0L-3uduA:
16.22
3ko0S-3uduA:
16.22
3ko0T-3uduA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		5 LEU A  62
ILE A  69
GLU A  92
LEU A  96
SER A  85
 None
 0.93A 3ko0K-3ue9A:
undetectable
3ko0L-3ue9A:
undetectable
3ko0S-3ue9A:
undetectable
3ko0T-3ue9A:
undetectable		 3ko0K-3ue9A:
13.17
3ko0L-3ue9A:
13.17
3ko0S-3ue9A:
13.17
3ko0T-3ue9A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 325
ILE A 229
LEU A 277
ASP A 342
PHE A 283
 None
 1.18A 3ko0K-3wdjA:
undetectable
3ko0L-3wdjA:
undetectable
3ko0S-3wdjA:
undetectable
3ko0T-3wdjA:
undetectable		 3ko0K-3wdjA:
9.15
3ko0L-3wdjA:
9.15
3ko0S-3wdjA:
9.15
3ko0T-3wdjA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		5 LEU A 281
PHE A 284
ILE A 334
LEU A 336
ASP A 337
 None
 1.19A 3ko0K-3wvsA:
undetectable
3ko0L-3wvsA:
undetectable
3ko0S-3wvsA:
undetectable
3ko0T-3wvsA:
undetectable		 3ko0K-3wvsA:
12.56
3ko0L-3wvsA:
12.56
3ko0S-3wvsA:
12.56
3ko0T-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 LEU A 430
ILE A 261
LEU A 434
ASP A 435
PHE A 776
 None
 0.85A 3ko0K-4ay2A:
undetectable
3ko0L-4ay2A:
undetectable
3ko0S-4ay2A:
undetectable
3ko0T-4ay2A:
undetectable		 3ko0K-4ay2A:
9.75
3ko0L-4ay2A:
9.75
3ko0S-4ay2A:
9.75
3ko0T-4ay2A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 LEU A 332
PHE A 327
ILE A 325
ASP A 318
ASP A 351
 None
 1.19A 3ko0K-4bhdA:
undetectable
3ko0L-4bhdA:
undetectable
3ko0S-4bhdA:
undetectable
3ko0T-4bhdA:
undetectable		 3ko0K-4bhdA:
12.38
3ko0L-4bhdA:
12.38
3ko0S-4bhdA:
12.38
3ko0T-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 LEU A 113
ILE A  89
LEU A  53
PHE A  78
SER A  69
 None
 1.22A 3ko0K-4dh2A:
undetectable
3ko0L-4dh2A:
undetectable
3ko0S-4dh2A:
undetectable
3ko0T-4dh2A:
undetectable		 3ko0K-4dh2A:
20.47
3ko0L-4dh2A:
20.47
3ko0S-4dh2A:
20.47
3ko0T-4dh2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 LEU A  41
SER A  38
PHE A  40
ILE A  57
LEU A 183
 None
 1.16A 3ko0K-4eq5A:
undetectable
3ko0L-4eq5A:
undetectable
3ko0S-4eq5A:
undetectable
3ko0T-4eq5A:
undetectable		 3ko0K-4eq5A:
11.80
3ko0L-4eq5A:
11.80
3ko0S-4eq5A:
11.80
3ko0T-4eq5A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		5 LEU A 138
SER A 134
ILE A 141
LEU A 183
ASP A 184
 None
 1.20A 3ko0K-4f53A:
undetectable
3ko0L-4f53A:
undetectable
3ko0S-4f53A:
undetectable
3ko0T-4f53A:
undetectable		 3ko0K-4f53A:
10.94
3ko0L-4f53A:
10.94
3ko0S-4f53A:
10.94
3ko0T-4f53A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 228
SER A 231
PHE A 252
GLU A 214
PHE A 208
 None
 1.13A 3ko0K-4fidA:
undetectable
3ko0L-4fidA:
undetectable
3ko0S-4fidA:
undetectable
3ko0T-4fidA:
undetectable		 3ko0K-4fidA:
15.16
3ko0L-4fidA:
15.16
3ko0S-4fidA:
15.16
3ko0T-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 LEU A 364
ILE A 368
GLU A 350
LEU A 347
ASP A 346
 None
 0.99A 3ko0K-4iggA:
undetectable
3ko0L-4iggA:
undetectable
3ko0S-4iggA:
undetectable
3ko0T-4iggA:
undetectable		 3ko0K-4iggA:
9.16
3ko0L-4iggA:
9.16
3ko0S-4iggA:
9.16
3ko0T-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE

([Oscillatoria]
sp. PCC 6506) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 100
ILE A 169
LEU A 167
ASP A 166
SER A  46
 None
 1.19A 3ko0K-4irnA:
undetectable
3ko0L-4irnA:
0.6
3ko0S-4irnA:
undetectable
3ko0T-4irnA:
undetectable		 3ko0K-4irnA:
12.62
3ko0L-4irnA:
12.62
3ko0S-4irnA:
12.62
3ko0T-4irnA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		5 LEU A  45
PHE A  66
ILE A  11
LEU A 240
ASP A 241
 None
 1.11A 3ko0K-4iwmA:
undetectable
3ko0L-4iwmA:
undetectable
3ko0S-4iwmA:
1.2
3ko0T-4iwmA:
undetectable		 3ko0K-4iwmA:
17.05
3ko0L-4iwmA:
17.05
3ko0S-4iwmA:
17.05
3ko0T-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		5 LEU A 235
ILE A  98
LEU A 108
ASP A 109
SER A 353
 None
 0.95A 3ko0K-4j1lA:
undetectable
3ko0L-4j1lA:
undetectable
3ko0S-4j1lA:
undetectable
3ko0T-4j1lA:
undetectable		 3ko0K-4j1lA:
14.29
3ko0L-4j1lA:
14.29
3ko0S-4j1lA:
14.29
3ko0T-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		5 LEU A1524
SER A1523
ILE A1481
LEU A1480
ASP A1476
 None
 1.17A 3ko0K-4lnzA:
1.7
3ko0L-4lnzA:
1.7
3ko0S-4lnzA:
1.6
3ko0T-4lnzA:
1.7		 3ko0K-4lnzA:
14.90
3ko0L-4lnzA:
14.90
3ko0S-4lnzA:
14.90
3ko0T-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6g UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF15598
(Imm61) 		5 LEU A   8
SER A   9
ILE A  16
GLU A  78
LEU A  81
 None
 1.21A 3ko0K-4o6gA:
undetectable
3ko0L-4o6gA:
undetectable
3ko0S-4o6gA:
undetectable
3ko0T-4o6gA:
undetectable		 3ko0K-4o6gA:
22.15
3ko0L-4o6gA:
22.15
3ko0S-4o6gA:
22.15
3ko0T-4o6gA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 LEU A  16
SER A  19
ILE A  52
LEU A  73
SER A 317
 None
 1.10A 3ko0K-4o89A:
undetectable
3ko0L-4o89A:
undetectable
3ko0S-4o89A:
undetectable
3ko0T-4o89A:
undetectable		 3ko0K-4o89A:
15.84
3ko0L-4o89A:
15.84
3ko0S-4o89A:
15.84
3ko0T-4o89A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 430
ILE A 261
LEU A 434
ASP A 435
PHE A 776
 None
 0.88A 3ko0K-4on9A:
undetectable
3ko0L-4on9A:
undetectable
3ko0S-4on9A:
undetectable
3ko0T-4on9A:
undetectable		 3ko0K-4on9A:
10.86
3ko0L-4on9A:
10.86
3ko0S-4on9A:
10.86
3ko0T-4on9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 LEU A  85
PHE A  92
ILE A  67
LEU A 129
PHE A 119
 None
 1.19A 3ko0K-4p53A:
undetectable
3ko0L-4p53A:
undetectable
3ko0S-4p53A:
undetectable
3ko0T-4p53A:
undetectable		 3ko0K-4p53A:
12.62
3ko0L-4p53A:
12.62
3ko0S-4p53A:
12.62
3ko0T-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 LEU A  70
SER A  67
ILE A 292
GLU A 132
PHE A  65
 None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
UNX  A 408 ( 4.8A)
 1.17A 3ko0K-4pwyA:
undetectable
3ko0L-4pwyA:
undetectable
3ko0S-4pwyA:
undetectable
3ko0T-4pwyA:
undetectable		 3ko0K-4pwyA:
18.85
3ko0L-4pwyA:
18.85
3ko0S-4pwyA:
18.85
3ko0T-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 LEU A  51
SER A  54
ILE A  78
PHE A1722
LEU A  74
 None
 1.16A 3ko0K-4r04A:
undetectable
3ko0L-4r04A:
undetectable
3ko0S-4r04A:
undetectable
3ko0T-4r04A:
undetectable		 3ko0K-4r04A:
4.44
3ko0L-4r04A:
4.44
3ko0S-4r04A:
4.44
3ko0T-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 390
ILE A 382
CYH A 409
LEU A 377
ASP A 405
 None
 0.94A 3ko0K-4r5dA:
undetectable
3ko0L-4r5dA:
undetectable
3ko0S-4r5dA:
undetectable
3ko0T-4r5dA:
undetectable		 3ko0K-4r5dA:
10.93
3ko0L-4r5dA:
10.93
3ko0S-4r5dA:
10.93
3ko0T-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r94 NON-STRUCTURAL
PROTEIN NS1

(Rodent
protoparvovirus
1) 		PF12433
(PV_NSP1) 		5 LEU A  37
ILE A  42
CYH A 161
GLU A 169
LEU A 173
 None
 1.19A 3ko0K-4r94A:
0.7
3ko0L-4r94A:
undetectable
3ko0S-4r94A:
undetectable
3ko0T-4r94A:
0.7		 3ko0K-4r94A:
16.86
3ko0L-4r94A:
16.86
3ko0S-4r94A:
16.86
3ko0T-4r94A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		5 LEU A  95
ILE A 120
LEU A 114
ASP A 113
PHE A 162
 None
 1.11A 3ko0K-4s1aA:
undetectable
3ko0L-4s1aA:
undetectable
3ko0S-4s1aA:
undetectable
3ko0T-4s1aA:
undetectable		 3ko0K-4s1aA:
18.98
3ko0L-4s1aA:
18.98
3ko0S-4s1aA:
18.98
3ko0T-4s1aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 409
PHE A 408
ILE A 396
LEU A 400
ASP A 401
 None
 1.09A 3ko0K-4up7A:
undetectable
3ko0L-4up7A:
undetectable
3ko0S-4up7A:
undetectable
3ko0T-4up7A:
undetectable		 3ko0K-4up7A:
9.51
3ko0L-4up7A:
9.51
3ko0S-4up7A:
9.51
3ko0T-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 577
ILE A 573
LEU A 588
ASP A 587
PHE A 627
 None
 1.01A 3ko0K-4z61A:
undetectable
3ko0L-4z61A:
undetectable
3ko0S-4z61A:
undetectable
3ko0T-4z61A:
undetectable		 3ko0K-4z61A:
10.84
3ko0L-4z61A:
10.84
3ko0S-4z61A:
10.84
3ko0T-4z61A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 567
ILE A 563
LEU A 578
ASP A 577
PHE A 617
 None
 1.06A 3ko0K-4z64A:
undetectable
3ko0L-4z64A:
undetectable
3ko0S-4z64A:
undetectable
3ko0T-4z64A:
undetectable		 3ko0K-4z64A:
11.79
3ko0L-4z64A:
11.79
3ko0S-4z64A:
11.79
3ko0T-4z64A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 LEU A 735
ILE A  21
PHE A 115
GLU A 724
ASP A 593
 None
 1.22A 3ko0K-5ah5A:
undetectable
3ko0L-5ah5A:
undetectable
3ko0S-5ah5A:
undetectable
3ko0T-5ah5A:
undetectable		 3ko0K-5ah5A:
7.86
3ko0L-5ah5A:
7.86
3ko0S-5ah5A:
7.86
3ko0T-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		5 LEU A  50
SER A  51
ILE A  46
GLU A 106
LEU A 109
 None
 1.03A 3ko0K-5azdA:
1.6
3ko0L-5azdA:
1.7
3ko0S-5azdA:
1.5
3ko0T-5azdA:
1.7		 3ko0K-5azdA:
15.53
3ko0L-5azdA:
15.53
3ko0S-5azdA:
15.53
3ko0T-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 LEU B 168
SER B  83
PHE B  82
LEU A 387
ASP B  16
 None
None
None
None
EDO  B 205 (-3.6A)
 1.16A 3ko0K-5b8iB:
6.2
3ko0L-5b8iB:
6.3
3ko0S-5b8iB:
6.2
3ko0T-5b8iB:
6.2		 3ko0K-5b8iB:
19.54
3ko0L-5b8iB:
19.54
3ko0S-5b8iB:
19.54
3ko0T-5b8iB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 338
SER A 339
PHE A 341
ILE A 426
LEU A 446
 None
 1.20A 3ko0K-5c4tA:
1.0
3ko0L-5c4tA:
undetectable
3ko0S-5c4tA:
1.1
3ko0T-5c4tA:
undetectable		 3ko0K-5c4tA:
17.08
3ko0L-5c4tA:
17.08
3ko0S-5c4tA:
17.08
3ko0T-5c4tA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.22A 3ko0K-5dwzC:
undetectable
3ko0L-5dwzC:
undetectable
3ko0S-5dwzC:
undetectable
3ko0T-5dwzC:
undetectable		 3ko0K-5dwzC:
14.11
3ko0L-5dwzC:
14.11
3ko0S-5dwzC:
14.11
3ko0T-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		5 LEU E 285
PHE E 246
ILE E 213
LEU E 209
ASP E 237
 None
 1.21A 3ko0K-5esvE:
undetectable
3ko0L-5esvE:
undetectable
3ko0S-5esvE:
undetectable
3ko0T-5esvE:
undetectable		 3ko0K-5esvE:
20.39
3ko0L-5esvE:
20.39
3ko0S-5esvE:
20.39
3ko0T-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 LEU D 394
ILE D 401
CYH D 405
LEU D 382
ASP D 358
 None
 1.23A 3ko0K-5exrD:
undetectable
3ko0L-5exrD:
undetectable
3ko0S-5exrD:
undetectable
3ko0T-5exrD:
undetectable		 3ko0K-5exrD:
13.78
3ko0L-5exrD:
13.78
3ko0S-5exrD:
13.78
3ko0T-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		5 LEU A 112
PHE A 109
ILE A 127
LEU A 167
ASP A 214
 None
 1.20A 3ko0K-5frsA:
undetectable
3ko0L-5frsA:
undetectable
3ko0S-5frsA:
undetectable
3ko0T-5frsA:
undetectable		 3ko0K-5frsA:
8.68
3ko0L-5frsA:
8.68
3ko0S-5frsA:
8.68
3ko0T-5frsA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 LEU A 230
ILE A 105
LEU A 271
ASP A 240
SER A  51
 None
None
None
SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
 1.17A 3ko0K-5hxsA:
undetectable
3ko0L-5hxsA:
undetectable
3ko0S-5hxsA:
undetectable
3ko0T-5hxsA:
undetectable		 3ko0K-5hxsA:
12.62
3ko0L-5hxsA:
12.62
3ko0S-5hxsA:
12.62
3ko0T-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 143
SER B 134
ILE B 183
LEU B 164
ASP B 138
 None
 1.08A 3ko0K-5k1cB:
undetectable
3ko0L-5k1cB:
undetectable
3ko0S-5k1cB:
undetectable
3ko0T-5k1cB:
undetectable		 3ko0K-5k1cB:
9.96
3ko0L-5k1cB:
9.96
3ko0S-5k1cB:
9.96
3ko0T-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		5 LEU A 415
PHE A 398
ILE A 443
PHE A  64
SER A 154
 None
 1.22A 3ko0K-5kcaA:
undetectable
3ko0L-5kcaA:
undetectable
3ko0S-5kcaA:
undetectable
3ko0T-5kcaA:
undetectable		 3ko0K-5kcaA:
7.91
3ko0L-5kcaA:
7.91
3ko0S-5kcaA:
7.91
3ko0T-5kcaA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 5 LEU A 129
ILE A 104
LEU A 107
ASP A 108
PHE A  75
 None
 1.18A 3ko0K-5ubvA:
undetectable
3ko0L-5ubvA:
undetectable
3ko0S-5ubvA:
undetectable
3ko0T-5ubvA:
undetectable		 3ko0K-5ubvA:
21.05
3ko0L-5ubvA:
21.05
3ko0S-5ubvA:
21.05
3ko0T-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA

(Yersinia pestis) 		PF01297
(ZnuA) 		5 LEU A 185
ILE A 298
PHE A 254
ASP A 303
SER A 194
 None
 1.18A 3ko0K-5uygA:
undetectable
3ko0L-5uygA:
undetectable
3ko0S-5uygA:
undetectable
3ko0T-5uygA:
undetectable		 3ko0K-5uygA:
13.62
3ko0L-5uygA:
13.62
3ko0S-5uygA:
13.62
3ko0T-5uygA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 SER B 145
ILE B 150
LEU B 111
ASP B 109
ASP B  72
 None
 1.09A 3ko0K-5y3rB:
undetectable
3ko0L-5y3rB:
undetectable
3ko0S-5y3rB:
undetectable
3ko0T-5y3rB:
undetectable		 3ko0K-5y3rB:
11.39
3ko0L-5y3rB:
11.39
3ko0S-5y3rB:
11.39
3ko0T-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b1z GLUTAMATE--TRNA
LIGASE

(Elizabethkingia
anophelis) 		PF00749
(tRNA-synt_1c) 		5 ILE A 486
LEU A 482
ASP A 481
PHE A 439
SER A 447
 None
None
FMT  A 614 (-3.6A)
None
None
 1.19A 3ko0K-6b1zA:
undetectable
3ko0L-6b1zA:
undetectable
3ko0S-6b1zA:
undetectable
3ko0T-6b1zA:
undetectable		 3ko0K-6b1zA:
10.96
3ko0L-6b1zA:
10.96
3ko0S-6b1zA:
10.96
3ko0T-6b1zA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 LEU A 329
ILE A 308
LEU A 310
ASP A 386
SER A 333
 None
 1.06A 3ko0K-6bbpA:
undetectable
3ko0L-6bbpA:
undetectable
3ko0S-6bbpA:
undetectable
3ko0T-6bbpA:
undetectable		 3ko0K-6bbpA:
20.56
3ko0L-6bbpA:
20.56
3ko0S-6bbpA:
20.56
3ko0T-6bbpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 5 LEU A 271
SER A 270
ILE A 277
LEU A 337
ASP A 356
 None
 1.22A 3ko0K-6cc2A:
undetectable
3ko0L-6cc2A:
undetectable
3ko0S-6cc2A:
undetectable
3ko0T-6cc2A:
undetectable		 3ko0K-6cc2A:
16.67
3ko0L-6cc2A:
16.67
3ko0S-6cc2A:
16.67
3ko0T-6cc2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
 None
 1.05A 3ko0K-6evjB:
undetectable
3ko0L-6evjB:
undetectable
3ko0S-6evjB:
undetectable
3ko0T-6evjB:
undetectable		 3ko0K-6evjB:
17.92
3ko0L-6evjB:
17.92
3ko0S-6evjB:
17.92
3ko0T-6evjB:
17.92