SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_K_TFPK201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoh CELLULOSOMAL-SCAFFOL
DING PROTEIN A


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
4 ILE A  23
PHE A  27
PHE A  82
PHE A  40
None
1.05A 3ko0K-1aohA:
undetectable
3ko0S-1aohA:
undetectable
3ko0K-1aohA:
19.21
3ko0S-1aohA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus)
PF00079
(Serpin)
4 ILE A 389
PHE A 124
PHE A 107
PHE A 109
None
1.04A 3ko0K-1attA:
0.3
3ko0S-1attA:
0.3
3ko0K-1attA:
11.81
3ko0S-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8b SPORE PROTEASE

(Bacillus
megaterium)
PF03418
(Peptidase_A25)
4 GLY A 620
ILE A 742
MET A 745
PHE A 496
None
0.99A 3ko0K-1c8bA:
undetectable
3ko0S-1c8bA:
undetectable
3ko0K-1c8bA:
13.75
3ko0S-1c8bA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1)
PF00082
(Peptidase_S8)
4 GLY A 183
ILE A 210
MET A 222
PHE A 194
None
0.70A 3ko0K-1dbiA:
undetectable
3ko0S-1dbiA:
undetectable
3ko0K-1dbiA:
15.02
3ko0S-1dbiA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)


(Agrobacterium
tumefaciens)
PF00561
(Abhydrolase_1)
4 GLY A  37
ILE A 219
PHE A 155
PHE A 179
None
0.98A 3ko0K-1ehyA:
0.2
3ko0S-1ehyA:
0.7
3ko0K-1ehyA:
15.52
3ko0S-1ehyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Thermotoga
maritima)
PF01380
(SIS)
4 ILE A 155
MET A 154
PHE A  19
PHE A  22
None
0.95A 3ko0K-1j5xA:
undetectable
3ko0S-1j5xA:
undetectable
3ko0K-1j5xA:
15.98
3ko0S-1j5xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
4 GLY A2825
PHE A2636
PHE A2600
PHE A2647
None
0.99A 3ko0K-1js8A:
undetectable
3ko0S-1js8A:
undetectable
3ko0K-1js8A:
13.47
3ko0S-1js8A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus)
PF14592
(Chondroitinas_B)
4 GLY A 119
ILE A 162
CYH A 203
PHE A 204
None
1.03A 3ko0K-1ofmA:
undetectable
3ko0S-1ofmA:
undetectable
3ko0K-1ofmA:
10.86
3ko0S-1ofmA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)


(Ascophyllum
nodosum)
no annotation 4 GLY A 417
ILE A 492
PHE A 195
PHE A 207
VO4  A 600 (-3.8A)
None
None
None
0.91A 3ko0K-1qi9A:
0.0
3ko0S-1qi9A:
0.0
3ko0K-1qi9A:
11.13
3ko0S-1qi9A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA


(Paracoccus
denitrificans)
PF00115
(COX1)
4 GLY A  95
ILE A 282
PHE A 422
PHE A 425
HEA  A 601 ( 4.0A)
HEA  A 602 ( 4.7A)
None
None
1.05A 3ko0K-1qleA:
undetectable
3ko0S-1qleA:
undetectable
3ko0K-1qleA:
10.65
3ko0S-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE


(Staphylococcus
aureus)
PF01551
(Peptidase_M23)
4 GLY A  65
ILE A  53
PHE A  81
PHE A  91
None
0.92A 3ko0K-1qwyA:
undetectable
3ko0S-1qwyA:
undetectable
3ko0K-1qwyA:
11.34
3ko0S-1qwyA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae)
PF03561
(Allantoicase)
4 GLY A  27
ILE A  95
PHE A 141
PHE A 178
None
0.97A 3ko0K-1sg3A:
undetectable
3ko0S-1sg3A:
undetectable
3ko0K-1sg3A:
15.34
3ko0S-1sg3A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE


(Homo sapiens)
PF00270
(DEAD)
4 GLY A  46
ILE A  80
PHE A  99
PHE A 227
None
0.95A 3ko0K-1t6nA:
0.0
3ko0S-1t6nA:
0.0
3ko0K-1t6nA:
18.18
3ko0S-1t6nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans)
PF13277
(YmdB)
4 GLY A 187
ILE A 170
PHE A  31
PHE A 239
None
1.05A 3ko0K-1t70A:
undetectable
3ko0S-1t70A:
undetectable
3ko0K-1t70A:
15.94
3ko0S-1t70A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tba TRANSCRIPTION
INITIATION FACTOR
IID 230K CHAIN
TRANSCRIPTION
INITIATION FACTOR
TFIID


(Drosophila
melanogaster;
Saccharomyces
cerevisiae)
PF00352
(TBP)
PF09247
(TBP-binding)
4 GLY A  57
ILE B 194
PHE A  25
PHE A  48
None
0.93A 3ko0K-1tbaA:
undetectable
3ko0S-1tbaA:
undetectable
3ko0K-1tbaA:
21.69
3ko0S-1tbaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
4 GLY A 288
ILE A 304
PHE A 388
PHE A 375
GLY  A 288 ( 0.0A)
ILE  A 304 ( 0.7A)
PHE  A 388 ( 1.3A)
PHE  A 375 ( 1.3A)
0.95A 3ko0K-1tedA:
0.0
3ko0S-1tedA:
0.0
3ko0K-1tedA:
11.96
3ko0S-1tedA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5l PRION PROTEIN

(Trachemys
scripta)
PF00377
(Prion)
4 GLY A 123
ILE A 210
MET A 213
CYH A 214
None
0.79A 3ko0K-1u5lA:
undetectable
3ko0S-1u5lA:
0.4
3ko0K-1u5lA:
18.75
3ko0S-1u5lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5l PRION PROTEIN

(Trachemys
scripta)
PF00377
(Prion)
4 GLY A 124
ILE A 210
MET A 213
CYH A 214
None
0.93A 3ko0K-1u5lA:
undetectable
3ko0S-1u5lA:
0.4
3ko0K-1u5lA:
18.75
3ko0S-1u5lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY


(Thermotoga
maritima)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 GLY A  10
ILE A 255
PHE A  81
PHE A 287
None
0.97A 3ko0K-1vmaA:
2.4
3ko0S-1vmaA:
2.6
3ko0K-1vmaA:
14.05
3ko0S-1vmaA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 GLY A  89
PHE A  95
PHE A 120
PHE A  82
None
1.03A 3ko0K-1xc6A:
undetectable
3ko0S-1xc6A:
undetectable
3ko0K-1xc6A:
6.85
3ko0S-1xc6A:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 GLY A  46
ILE A  80
PHE A  99
PHE A 227
None
1.05A 3ko0K-1xtjA:
0.0
3ko0S-1xtjA:
0.0
3ko0K-1xtjA:
13.39
3ko0S-1xtjA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN


(Saccharomyces
cerevisiae)
PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd)
4 GLY A 424
ILE A 694
PHE A 540
PHE A 662
None
0.96A 3ko0K-1z45A:
undetectable
3ko0S-1z45A:
undetectable
3ko0K-1z45A:
9.59
3ko0S-1z45A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae8 IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE


(Staphylococcus
aureus)
PF00475
(IGPD)
4 GLY A  73
ILE A  51
PHE A 127
PHE A 135
None
0.95A 3ko0K-2ae8A:
1.4
3ko0S-2ae8A:
1.3
3ko0K-2ae8A:
14.68
3ko0S-2ae8A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens)
PF00079
(Serpin)
4 GLY I 339
PHE I 123
PHE I 106
PHE I 108
None
0.90A 3ko0K-2b4xI:
0.0
3ko0S-2b4xI:
0.0
3ko0K-2b4xI:
15.12
3ko0S-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens)
PF00079
(Serpin)
4 ILE I 420
PHE I 106
PHE I 108
PHE I 123
None
0.91A 3ko0K-2b4xI:
0.0
3ko0S-2b4xI:
0.0
3ko0K-2b4xI:
15.12
3ko0S-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
4 GLY A 308
ILE A 288
MET A 253
PHE A 331
None
0.94A 3ko0K-2bfwA:
0.9
3ko0S-2bfwA:
undetectable
3ko0K-2bfwA:
19.00
3ko0S-2bfwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
4 ILE A  23
PHE A  27
PHE A  82
PHE A  40
None
0.98A 3ko0K-2cclA:
undetectable
3ko0S-2cclA:
undetectable
3ko0K-2cclA:
20.13
3ko0S-2cclA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
4 GLY A 447
ILE A 181
PHE A 396
PHE A 476
None
0.99A 3ko0K-2g3nA:
undetectable
3ko0S-2g3nA:
undetectable
3ko0K-2g3nA:
11.28
3ko0S-2g3nA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gyq YCFI, PUTATIVE
STRUCTURAL PROTEIN


(Rhodopseudomonas
palustris)
PF05974
(DUF892)
4 GLY A  76
ILE A  22
PHE A 139
PHE A  67
None
0.89A 3ko0K-2gyqA:
1.4
3ko0S-2gyqA:
1.4
3ko0K-2gyqA:
19.25
3ko0S-2gyqA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6


(Homo sapiens)
PF00025
(Arf)
4 GLY A 167
ILE A  34
CYH A  22
PHE A  92
None
1.02A 3ko0K-2h57A:
0.0
3ko0S-2h57A:
0.0
3ko0K-2h57A:
18.65
3ko0S-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE


(Xanthomonas
campestris)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLY A 356
ILE A 419
PHE A 429
PHE A  14
None
0.95A 3ko0K-2hneA:
undetectable
3ko0S-2hneA:
undetectable
3ko0K-2hneA:
13.63
3ko0S-2hneA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT


(Thermus
aquaticus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
4 GLY A 174
ILE A 277
MET A 280
CYH A 281
None
0.58A 3ko0K-2hpiA:
0.5
3ko0S-2hpiA:
undetectable
3ko0K-2hpiA:
6.27
3ko0S-2hpiA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR


(Burkholderia
pseudomallei)
PF07487
(SopE_GEF)
4 GLY A 171
MET A 132
CYH A 131
PHE A 130
None
1.05A 3ko0K-2jokA:
undetectable
3ko0S-2jokA:
undetectable
3ko0K-2jokA:
17.20
3ko0S-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922


(Mycobacterium
tuberculosis)
PF00691
(OmpA)
PF04972
(BON)
4 GLY A 164
ILE A 188
PHE A 135
PHE A 142
None
0.92A 3ko0K-2l26A:
undetectable
3ko0S-2l26A:
undetectable
3ko0K-2l26A:
13.84
3ko0S-2l26A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1


(Thermotoga
maritima)
PF00749
(tRNA-synt_1c)
4 ILE A 330
PHE A 379
PHE A 371
PHE A 341
None
0.89A 3ko0K-2o5rA:
undetectable
3ko0S-2o5rA:
undetectable
3ko0K-2o5rA:
12.33
3ko0S-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1


(Thermotoga
maritima)
PF00749
(tRNA-synt_1c)
4 PHE A 378
PHE A 379
PHE A 371
PHE A 341
None
1.05A 3ko0K-2o5rA:
undetectable
3ko0S-2o5rA:
undetectable
3ko0K-2o5rA:
12.33
3ko0S-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I


(Escherichia
coli)
PF00365
(PFK)
4 GLY A 101
ILE A 296
PHE A 117
PHE A  76
None
1.03A 3ko0K-2pfkA:
undetectable
3ko0S-2pfkA:
undetectable
3ko0K-2pfkA:
14.20
3ko0S-2pfkA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euw MYO-INOSITOL
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 GLY A 111
ILE A  96
CYH A  92
PHE A 291
None
0.95A 3ko0K-3euwA:
undetectable
3ko0S-3euwA:
undetectable
3ko0K-3euwA:
11.92
3ko0S-3euwA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE


(Salmonella
enterica)
PF01238
(PMI_typeI)
4 ILE A 335
PHE A 344
PHE A  85
PHE A 323
None
0.76A 3ko0K-3h1wA:
undetectable
3ko0S-3h1wA:
undetectable
3ko0K-3h1wA:
12.28
3ko0S-3h1wA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn5 PUTATIVE EXPORTED
PROTEIN BF0290


(Bacteroides
fragilis)
PF12866
(DUF3823)
4 GLY A 149
ILE A 227
CYH A 217
PHE A 192
None
0.87A 3ko0K-3hn5A:
undetectable
3ko0S-3hn5A:
undetectable
3ko0K-3hn5A:
12.96
3ko0S-3hn5A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis)
PF01266
(DAO)
4 GLY A 308
ILE A 361
PHE A 209
PHE A 219
None
None
FAD  A 371 (-4.7A)
None
0.93A 3ko0K-3if9A:
undetectable
3ko0S-3if9A:
undetectable
3ko0K-3if9A:
13.23
3ko0S-3if9A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2


(Dichelobacter
nodosus)
PF00082
(Peptidase_S8)
4 GLY A 227
ILE A 254
MET A 273
PHE A 238
None
0.81A 3ko0K-3lpdA:
undetectable
3ko0S-3lpdA:
undetectable
3ko0K-3lpdA:
12.68
3ko0S-3lpdA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxz GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN


(Pseudomonas
putida)
PF13417
(GST_N_3)
PF14497
(GST_C_3)
4 GLY A 169
PHE A 142
PHE A 133
PHE A 181
None
0.93A 3ko0K-3lxzA:
undetectable
3ko0S-3lxzA:
undetectable
3ko0K-3lxzA:
19.65
3ko0S-3lxzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT


(Allochromatium
vinosum)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 GLY A  76
ILE B1041
PHE A 263
PHE A 257
SF4  A2001 ( 4.6A)
None
None
None
0.95A 3ko0K-3myrA:
undetectable
3ko0S-3myrA:
undetectable
3ko0K-3myrA:
17.52
3ko0S-3myrA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE


(Bacteroides
ovatus)
no annotation 4 GLY A 173
ILE A 204
CYH A 222
PHE A 251
None
1.02A 3ko0K-3n6zA:
undetectable
3ko0S-3n6zA:
undetectable
3ko0K-3n6zA:
15.10
3ko0S-3n6zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE


(Cytophaga
hutchinsonii)
PF01494
(FAD_binding_3)
4 GLY A 358
ILE A 303
PHE A 231
PHE A 238
None
0.86A 3ko0K-3nixA:
undetectable
3ko0S-3nixA:
undetectable
3ko0K-3nixA:
14.32
3ko0S-3nixA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opn PUTATIVE HEMOLYSIN

(Lactococcus
lactis)
PF01728
(FtsJ)
4 GLY A 150
ILE A 128
PHE A 108
PHE A 118
None
0.95A 3ko0K-3opnA:
undetectable
3ko0S-3opnA:
undetectable
3ko0K-3opnA:
16.38
3ko0S-3opnA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydomonas
reinhardtii)
PF00155
(Aminotran_1_2)
4 GLY A 438
ILE A 393
PHE A 414
PHE A 366
None
0.87A 3ko0K-3qguA:
undetectable
3ko0S-3qguA:
undetectable
3ko0K-3qguA:
12.44
3ko0S-3qguA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1


(Saccharomyces
cerevisiae)
PF01399
(PCI)
4 CYH B  65
PHE B  68
PHE B  90
PHE B  16
None
0.91A 3ko0K-3t5vB:
undetectable
3ko0S-3t5vB:
undetectable
3ko0K-3t5vB:
13.08
3ko0S-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE


(Plasmodium
falciparum)
PF00579
(tRNA-synt_1b)
4 GLY A  62
MET A 259
PHE A 353
PHE A 120
TYR  A 401 ( 3.3A)
None
None
None
0.99A 3ko0K-3vgjA:
undetectable
3ko0S-3vgjA:
undetectable
3ko0K-3vgjA:
15.55
3ko0S-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdo MFS TRANSPORTER

(Escherichia
coli)
PF07690
(MFS_1)
4 GLY A  69
ILE A 327
PHE A 144
PHE A  21
None
1.04A 3ko0K-3wdoA:
undetectable
3ko0S-3wdoA:
undetectable
3ko0K-3wdoA:
12.92
3ko0S-3wdoA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE


(Podospora
anserina)
PF00150
(Cellulase)
4 GLY A 256
PHE A 237
PHE A 240
PHE A 226
None
1.04A 3ko0K-3zizA:
undetectable
3ko0S-3zizA:
undetectable
3ko0K-3zizA:
11.52
3ko0S-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B


(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110)
4 GLY A  47
ILE A 112
PHE A 135
PHE A 144
None
0.89A 3ko0K-4b9yA:
undetectable
3ko0S-4b9yA:
undetectable
3ko0K-4b9yA:
7.71
3ko0S-4b9yA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 4 ILE A 353
PHE A 366
PHE A 291
PHE A 193
None
1.03A 3ko0K-4btpA:
1.5
3ko0S-4btpA:
1.5
3ko0K-4btpA:
9.18
3ko0S-4btpA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dw1 P2X PURINOCEPTOR

(Danio rerio)
PF00864
(P2X_receptor)
4 GLY A 253
PHE A 233
PHE A 322
PHE A 102
None
0.90A 3ko0K-4dw1A:
undetectable
3ko0S-4dw1A:
undetectable
3ko0K-4dw1A:
13.78
3ko0S-4dw1A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462


(Clostridium
acetobutylicum)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
4 GLY A 329
ILE A 317
PHE A 135
PHE A 214
None
0.83A 3ko0K-4eufA:
undetectable
3ko0S-4eufA:
undetectable
3ko0K-4eufA:
13.46
3ko0S-4eufA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT


(Rhodopseudomonas
palustris)
PF13458
(Peripla_BP_6)
4 GLY A 369
ILE A 240
PHE A 257
PHE A 306
None
None
PHB  A 406 (-3.8A)
PHB  A 406 (-4.4A)
0.97A 3ko0K-4evqA:
undetectable
3ko0S-4evqA:
undetectable
3ko0K-4evqA:
13.40
3ko0S-4evqA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fch OUTER MEMBRANE
PROTEIN SUSE


(Bacteroides
thetaiotaomicron)
PF16411
(SusF_SusE)
4 GLY A 289
PHE A 314
PHE A 379
PHE A 340
None
1.00A 3ko0K-4fchA:
undetectable
3ko0S-4fchA:
undetectable
3ko0K-4fchA:
15.07
3ko0S-4fchA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR


(Homo sapiens)
PF00079
(Serpin)
4 GLY A 292
PHE A  70
PHE A  58
PHE A  60
None
1.05A 3ko0K-4ga7A:
undetectable
3ko0S-4ga7A:
undetectable
3ko0K-4ga7A:
14.47
3ko0S-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
4 GLY L 508
ILE L 294
PHE L 532
PHE L 524
None
0.94A 3ko0K-4heaL:
0.5
3ko0S-4heaL:
undetectable
3ko0K-4heaL:
10.77
3ko0S-4heaL:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j75 TRYPTOPHANYL-TRNA
SYNTHETASE


(Plasmodium
falciparum)
PF00579
(tRNA-synt_1b)
4 ILE A 430
CYH A 433
PHE A 438
PHE A 383
None
0.97A 3ko0K-4j75A:
undetectable
3ko0S-4j75A:
undetectable
3ko0K-4j75A:
14.44
3ko0S-4j75A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j75 TRYPTOPHANYL-TRNA
SYNTHETASE


(Plasmodium
falciparum)
PF00579
(tRNA-synt_1b)
4 ILE A 430
PHE A 350
PHE A 412
PHE A 414
None
1.03A 3ko0K-4j75A:
undetectable
3ko0S-4j75A:
undetectable
3ko0K-4j75A:
14.44
3ko0S-4j75A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6


(Homo sapiens)
PF00328
(His_Phos_2)
4 GLY A 136
ILE A 161
PHE A 304
PHE A  57
None
0.77A 3ko0K-4jocA:
undetectable
3ko0S-4jocA:
undetectable
3ko0K-4jocA:
14.21
3ko0S-4jocA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt5 GRLR

(Escherichia
coli)
PF16518
(GrlR)
4 GLY A  34
ILE A  75
CYH A  90
PHE A  99
None
None
PG4  A 201 ( 4.6A)
None
1.02A 3ko0K-4kt5A:
undetectable
3ko0S-4kt5A:
undetectable
3ko0K-4kt5A:
22.56
3ko0S-4kt5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2k TANKYRASE-2

(Homo sapiens)
PF00644
(PARP)
4 GLY A1058
ILE A1039
PHE A1098
PHE A1061
None
1.00A 3ko0K-4l2kA:
undetectable
3ko0S-4l2kA:
undetectable
3ko0K-4l2kA:
16.75
3ko0S-4l2kA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oa7 TANKYRASE-1

(Homo sapiens)
PF00644
(PARP)
4 GLY A1211
ILE A1192
PHE A1251
PHE A1214
None
2XS  A1402 ( 4.7A)
None
None
0.97A 3ko0K-4oa7A:
undetectable
3ko0S-4oa7A:
undetectable
3ko0K-4oa7A:
19.81
3ko0S-4oa7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT


(Cupriavidus
necator)
PF03480
(DctP)
4 GLY A  46
ILE A 276
PHE A 136
PHE A 246
None
0.81A 3ko0K-4p8bA:
undetectable
3ko0S-4p8bA:
undetectable
3ko0K-4p8bA:
15.50
3ko0S-4p8bA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18


(Serratia
proteamaculans)
PF00704
(Glyco_hydro_18)
4 GLY A 195
ILE A 210
PHE A 132
PHE A 119
None
0.72A 3ko0K-4q22A:
undetectable
3ko0S-4q22A:
undetectable
3ko0K-4q22A:
13.23
3ko0S-4q22A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m)
4 ILE A 433
PHE A 386
PHE A 406
PHE A 437
None
0.94A 3ko0K-4q6pA:
undetectable
3ko0S-4q6pA:
undetectable
3ko0K-4q6pA:
13.56
3ko0S-4q6pA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18


(Pseudomonas
protegens)
PF00704
(Glyco_hydro_18)
4 GLY A 259
ILE A 178
PHE A 148
PHE A 159
None
1.00A 3ko0K-4q6tA:
undetectable
3ko0S-4q6tA:
undetectable
3ko0K-4q6tA:
13.24
3ko0S-4q6tA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE


(Leishmania
donovani)
PF00069
(Pkinase)
4 GLY A  84
ILE A 139
PHE A 328
PHE A 168
None
1.05A 3ko0K-4qnyA:
undetectable
3ko0S-4qnyA:
undetectable
3ko0K-4qnyA:
14.04
3ko0S-4qnyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Ochrobactrum
anthropi)
PF01547
(SBP_bac_1)
4 GLY A 225
ILE A 392
PHE A 400
PHE A 233
None
0.75A 3ko0K-4r2bA:
undetectable
3ko0S-4r2bA:
0.3
3ko0K-4r2bA:
15.68
3ko0S-4r2bA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcm METHYLATED
RNA-BINDING PROTEIN
1


(Saccharomyces
cerevisiae)
PF04146
(YTH)
4 GLY A 175
CYH A 213
PHE A 212
PHE A 290
UNX  A 405 ( 4.2A)
None
None
None
1.02A 3ko0K-4rcmA:
undetectable
3ko0S-4rcmA:
undetectable
3ko0K-4rcmA:
22.02
3ko0S-4rcmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92)
no annotation 4 GLY A 556
ILE A 638
CYH A 643
PHE A 615
None
0.87A 3ko0K-4rmxA:
undetectable
3ko0S-4rmxA:
undetectable
3ko0K-4rmxA:
11.52
3ko0S-4rmxA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA


(Homo sapiens)
PF09240
(IL6Ra-bind)
4 GLY B 158
ILE B 135
PHE B 105
PHE B 187
None
0.79A 3ko0K-4rs1B:
undetectable
3ko0S-4rs1B:
undetectable
3ko0K-4rs1B:
18.62
3ko0S-4rs1B:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2


(Pyrococcus
furiosus)
PF12469
(DUF3692)
4 GLY A 847
ILE A 807
PHE A 791
PHE A 858
None
0.93A 3ko0K-4w8yA:
undetectable
3ko0S-4w8yA:
undetectable
3ko0K-4w8yA:
9.05
3ko0S-4w8yA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB


(Drosophila
melanogaster)
PF10613
(Lig_chan-Glu_bd)
4 GLY A 222
ILE A 120
PHE A 177
PHE A 154
None
0.91A 3ko0K-4wxjA:
undetectable
3ko0S-4wxjA:
undetectable
3ko0K-4wxjA:
18.46
3ko0S-4wxjA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN


(Homo sapiens)
PF00955
(HCO3_cotransp)
4 GLY A 714
ILE A 487
PHE A 478
PHE A 471
None
0.79A 3ko0K-4yzfA:
undetectable
3ko0S-4yzfA:
undetectable
3ko0K-4yzfA:
8.35
3ko0S-4yzfA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT


(Squalus
acanthias)
PF00287
(Na_K-ATPase)
4 GLY B 295
ILE B 263
PHE B 152
PHE B 240
None
0.95A 3ko0K-5aw4B:
undetectable
3ko0S-5aw4B:
undetectable
3ko0K-5aw4B:
15.74
3ko0S-5aw4B:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvz COAT PROTEIN

(Panicum
papanivirus 1)
no annotation 4 GLY A  51
PHE A  39
PHE A  60
PHE A 147
None
0.88A 3ko0K-5cvzA:
undetectable
3ko0S-5cvzA:
undetectable
3ko0K-5cvzA:
16.77
3ko0S-5cvzA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens)
PF00644
(PARP)
4 GLY A1058
ILE A1039
PHE A1098
PHE A1061
None
1.02A 3ko0K-5dczA:
undetectable
3ko0S-5dczA:
undetectable
3ko0K-5dczA:
19.49
3ko0S-5dczA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGJ
YBGK


(Escherichia
coli)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
4 GLY A 254
ILE B   9
CYH A 260
PHE A 193
None
0.99A 3ko0K-5dudA:
undetectable
3ko0S-5dudA:
undetectable
3ko0K-5dudA:
16.39
3ko0S-5dudA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens)
PF00079
(Serpin)
4 GLY A 327
PHE A 116
PHE A 102
PHE A 104
None
0.90A 3ko0K-5ei0A:
undetectable
3ko0S-5ei0A:
undetectable
3ko0K-5ei0A:
13.45
3ko0S-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5r HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL


(Homo sapiens)
PF13589
(HATPase_c_3)
4 GLY A 162
ILE A 241
PHE A 209
PHE A 205
ANP  A 300 ( 4.5A)
None
None
None
0.88A 3ko0K-5f5rA:
undetectable
3ko0S-5f5rA:
undetectable
3ko0K-5f5rA:
18.22
3ko0S-5f5rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
4 GLY B 740
ILE B 754
PHE B 670
PHE B 657
None
0.86A 3ko0K-5gztB:
undetectable
3ko0S-5gztB:
undetectable
3ko0K-5gztB:
6.27
3ko0S-5gztB:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
4 GLY A 740
ILE A 754
PHE A 670
PHE A 657
None
0.83A 3ko0K-5gzuA:
undetectable
3ko0S-5gzuA:
undetectable
3ko0K-5gzuA:
7.23
3ko0S-5gzuA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN


(Enterococcus
faecalis)
no annotation 4 GLY A 445
ILE A 441
PHE A 367
PHE A 397
None
1.03A 3ko0K-5h29A:
undetectable
3ko0S-5h29A:
undetectable
3ko0K-5h29A:
22.12
3ko0S-5h29A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL


(Homo sapiens)
PF00183
(HSP90)
PF13589
(HATPase_c_3)
4 GLY A 162
ILE A 241
PHE A 209
PHE A 205
ANP  A 801 ( 4.3A)
None
None
None
0.94A 3ko0K-5hphA:
undetectable
3ko0S-5hphA:
undetectable
3ko0K-5hphA:
11.24
3ko0S-5hphA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN


(Stenotrophomonas
maltophilia)
PF12849
(PBP_like_2)
4 ILE A 140
PHE A 192
PHE A 121
PHE A 188
None
1.01A 3ko0K-5j1dA:
undetectable
3ko0S-5j1dA:
undetectable
3ko0K-5j1dA:
14.48
3ko0S-5j1dA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M)
4 GLY A 678
ILE A 567
PHE A 564
PHE A 656
None
0.98A 3ko0K-5l46A:
undetectable
3ko0S-5l46A:
undetectable
3ko0K-5l46A:
9.00
3ko0S-5l46A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT


(Clostridioides
difficile)
no annotation 4 GLY B 253
ILE A 270
CYH A 272
PHE A 302
None
0.95A 3ko0K-5ol2B:
undetectable
3ko0S-5ol2B:
undetectable
3ko0K-5ol2B:
18.60
3ko0S-5ol2B:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae)
no annotation 4 GLY B 298
PHE B 314
PHE B 301
PHE B 332
None
0.78A 3ko0K-5swiB:
undetectable
3ko0S-5swiB:
undetectable
3ko0K-5swiB:
10.84
3ko0S-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1


(Mus musculus)
PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3)
PF14598
(PAS_11)
4 GLY B 140
ILE A 178
CYH A 336
PHE A 335
None
0.97A 3ko0K-5sy5B:
undetectable
3ko0S-5sy5B:
undetectable
3ko0K-5sy5B:
14.73
3ko0S-5sy5B:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw6 P2X PURINOCEPTOR

(Gallus gallus)
no annotation 4 GLY C 237
PHE C 217
PHE C 304
PHE C  90
None
0.94A 3ko0K-5xw6C:
undetectable
3ko0S-5xw6C:
undetectable
3ko0K-5xw6C:
13.15
3ko0S-5xw6C:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-)
no annotation 4 GLY A 448
ILE A 480
PHE A 455
PHE A 431
None
0.92A 3ko0K-5zxdA:
undetectable
3ko0S-5zxdA:
undetectable
3ko0K-5zxdA:
undetectable
3ko0S-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6acd -

(-)
no annotation 4 GLY A1026
PHE A 782
PHE A 784
PHE A1034
None
1.04A 3ko0K-6acdA:
1.2
3ko0S-6acdA:
1.2
3ko0K-6acdA:
undetectable
3ko0S-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1


(Moorea
bouillonii)
no annotation 4 GLY A 133
ILE A 109
PHE A 156
PHE A 171
None
1.04A 3ko0K-6b3bA:
undetectable
3ko0S-6b3bA:
undetectable
3ko0K-6b3bA:
9.84
3ko0S-6b3bA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1


(Homo sapiens)
no annotation 4 GLY A 120
ILE A 166
PHE A 200
PHE A 181
None
0.89A 3ko0K-6b3xA:
undetectable
3ko0S-6b3xA:
undetectable
3ko0K-6b3xA:
14.37
3ko0S-6b3xA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5x SUPPRESSOR OF
CYTOKINE SIGNALLING
1


(Xenopus laevis)
no annotation 4 GLY D  99
PHE D 209
PHE D 207
PHE D  79
None
0.80A 3ko0K-6c5xD:
undetectable
3ko0S-6c5xD:
undetectable
3ko0K-6c5xD:
21.78
3ko0S-6c5xD:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT


(Methylomicrobium
alcaliphilum)
no annotation 4 GLY B 185
ILE A  91
MET A 141
PHE A  88
None
0.86A 3ko0K-6cxhB:
1.1
3ko0S-6cxhB:
1.1
3ko0K-6cxhB:
20.75
3ko0S-6cxhB:
20.75