SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_J_TFPJ202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		5 PHE A 159
LEU A 205
ASP A 204
LEU A 172
ILE A 189
 None
 1.29A 3ko0A-1ac5A:
undetectable
3ko0B-1ac5A:
0.0
3ko0I-1ac5A:
0.0
3ko0J-1ac5A:
0.0		 3ko0A-1ac5A:
13.14
3ko0B-1ac5A:
13.14
3ko0I-1ac5A:
13.14
3ko0J-1ac5A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 SER A 130
ASP A 145
LEU A 142
PHE A  86
ILE A  18
 None
 1.24A 3ko0A-1ag9A:
undetectable
3ko0B-1ag9A:
undetectable
3ko0I-1ag9A:
undetectable
3ko0J-1ag9A:
undetectable		 3ko0A-1ag9A:
22.70
3ko0B-1ag9A:
22.70
3ko0I-1ag9A:
22.70
3ko0J-1ag9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czk FLAVODOXIN

(Synechococcus
elongatus) 		PF00258
(Flavodoxin_1) 		5 SER A 130
ASP A 144
LEU A 141
PHE A  86
ILE A  17
 None
 1.23A 3ko0A-1czkA:
undetectable
3ko0B-1czkA:
undetectable
3ko0I-1czkA:
undetectable
3ko0J-1czkA:
undetectable		 3ko0A-1czkA:
21.02
3ko0B-1czkA:
21.02
3ko0I-1czkA:
21.02
3ko0J-1czkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		5 ASP A 116
LEU A 125
LEU A  82
PHE A  81
CYH A  99
 None
None
None
None
NAD  A1382 (-4.5A)
 1.14A 3ko0A-1gy8A:
undetectable
3ko0B-1gy8A:
undetectable
3ko0I-1gy8A:
undetectable
3ko0J-1gy8A:
undetectable		 3ko0A-1gy8A:
13.92
3ko0B-1gy8A:
13.92
3ko0I-1gy8A:
13.92
3ko0J-1gy8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 135
LEU A 192
PHE A 155
ILE A  85
PHE A  82
 None
 1.27A 3ko0A-1ig8A:
undetectable
3ko0B-1ig8A:
0.0
3ko0I-1ig8A:
0.0
3ko0J-1ig8A:
0.0		 3ko0A-1ig8A:
12.32
3ko0B-1ig8A:
12.32
3ko0I-1ig8A:
12.32
3ko0J-1ig8A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 SER A 184
PHE A 323
ASP A 319
LEU A 314
ILE A  83
 None
 1.26A 3ko0A-1imvA:
undetectable
3ko0B-1imvA:
undetectable
3ko0I-1imvA:
undetectable
3ko0J-1imvA:
undetectable		 3ko0A-1imvA:
13.28
3ko0B-1imvA:
13.28
3ko0I-1imvA:
13.28
3ko0J-1imvA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn1 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Haemophilus
influenzae) 		PF02542
(YgbB) 		5 ASP A  73
LEU A  45
LEU A 121
PHE A  82
ILE A  49
 None
 1.17A 3ko0A-1jn1A:
undetectable
3ko0B-1jn1A:
undetectable
3ko0I-1jn1A:
undetectable
3ko0J-1jn1A:
undetectable		 3ko0A-1jn1A:
20.67
3ko0B-1jn1A:
20.67
3ko0I-1jn1A:
20.67
3ko0J-1jn1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mfw DOUBLECORTIN-LIKE
KINASE (N-TERMINAL
DOMAIN)

(Homo sapiens) 		PF03607
(DCX) 		5 LEU A 123
ASP A 121
LEU A  87
PHE A  81
ILE A  76
 None
 1.21A 3ko0A-1mfwA:
undetectable
3ko0B-1mfwA:
undetectable
3ko0I-1mfwA:
undetectable
3ko0J-1mfwA:
undetectable		 3ko0A-1mfwA:
21.43
3ko0B-1mfwA:
21.43
3ko0I-1mfwA:
21.43
3ko0J-1mfwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 ASP A 482
ASP A 439
LEU A 436
SER A 486
ILE A 423
 None
 1.18A 3ko0A-1pz3A:
undetectable
3ko0B-1pz3A:
undetectable
3ko0I-1pz3A:
undetectable
3ko0J-1pz3A:
undetectable		 3ko0A-1pz3A:
12.17
3ko0B-1pz3A:
12.17
3ko0I-1pz3A:
12.17
3ko0J-1pz3A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A 325
LEU A 296
SER A 297
PHE A 301
ILE A 304
 None
 1.07A 3ko0A-1pztA:
undetectable
3ko0B-1pztA:
undetectable
3ko0I-1pztA:
undetectable
3ko0J-1pztA:
undetectable		 3ko0A-1pztA:
17.80
3ko0B-1pztA:
17.80
3ko0I-1pztA:
17.80
3ko0J-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 ASP A  24
LEU A  64
LEU A  32
PHE A  29
ILE A 108
 None
 1.25A 3ko0A-1q3bA:
1.4
3ko0B-1q3bA:
1.5
3ko0I-1q3bA:
1.4
3ko0J-1q3bA:
1.4		 3ko0A-1q3bA:
17.05
3ko0B-1q3bA:
17.05
3ko0I-1q3bA:
17.05
3ko0J-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 ASP A 277
SER A 280
LEU A 110
ASP A 111
LEU A 243
 None
 1.02A 3ko0A-1vp4A:
undetectable
3ko0B-1vp4A:
0.0
3ko0I-1vp4A:
0.0
3ko0J-1vp4A:
0.0		 3ko0A-1vp4A:
13.44
3ko0B-1vp4A:
13.44
3ko0I-1vp4A:
13.44
3ko0J-1vp4A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlg FLAGELLAR HOOK
PROTEIN FLGE

(Salmonella
enterica) 		PF07559
(FlaE) 		5 SER A  94
LEU A  72
ASP A  73
LEU A 107
ILE A 293
 None
 1.16A 3ko0A-1wlgA:
undetectable
3ko0B-1wlgA:
undetectable
3ko0I-1wlgA:
undetectable
3ko0J-1wlgA:
undetectable		 3ko0A-1wlgA:
17.69
3ko0B-1wlgA:
17.69
3ko0I-1wlgA:
17.69
3ko0J-1wlgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)

(Sulfurisphaera
tokodaii) 		PF01923
(Cob_adeno_trans) 		5 LEU A  31
ASP A  32
LEU A  68
SER A  69
ILE A  64
 POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
None
None
None
 1.18A 3ko0A-1wozA:
1.3
3ko0B-1wozA:
0.9
3ko0I-1wozA:
1.0
3ko0J-1wozA:
0.9		 3ko0A-1wozA:
20.57
3ko0B-1wozA:
20.57
3ko0I-1wozA:
20.57
3ko0J-1wozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 303
LEU A 285
SER A 266
ILE A 301
PHE A 224
 None
 1.12A 3ko0A-1x9eA:
undetectable
3ko0B-1x9eA:
0.0
3ko0I-1x9eA:
0.0
3ko0J-1x9eA:
0.0		 3ko0A-1x9eA:
14.44
3ko0B-1x9eA:
14.44
3ko0I-1x9eA:
14.44
3ko0J-1x9eA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 ASP A  13
LEU A  25
SER A  24
ILE A  36
CYH A  10
 None
 1.17A 3ko0A-1zzmA:
undetectable
3ko0B-1zzmA:
0.0
3ko0I-1zzmA:
0.0
3ko0J-1zzmA:
0.0		 3ko0A-1zzmA:
14.89
3ko0B-1zzmA:
14.89
3ko0I-1zzmA:
14.89
3ko0J-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 SER A 186
LEU A 151
SER A 154
PHE A 156
ILE A 331
 None
 1.23A 3ko0A-2c4kA:
undetectable
3ko0B-2c4kA:
undetectable
3ko0I-2c4kA:
undetectable
3ko0J-2c4kA:
undetectable		 3ko0A-2c4kA:
12.83
3ko0B-2c4kA:
12.83
3ko0I-2c4kA:
12.83
3ko0J-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		5 LEU A 274
ASP A 273
LEU A 262
ILE A 288
PHE A  77
 None
APC  A1375 ( 4.3A)
None
None
None
 1.29A 3ko0A-2c5uA:
1.6
3ko0B-2c5uA:
0.0
3ko0I-2c5uA:
1.5
3ko0J-2c5uA:
undetectable		 3ko0A-2c5uA:
14.40
3ko0B-2c5uA:
14.40
3ko0I-2c5uA:
14.40
3ko0J-2c5uA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 SER A 168
LEU A  59
LEU A 175
ILE A  55
PHE A   7
 None
 1.16A 3ko0A-2e0iA:
undetectable
3ko0B-2e0iA:
0.0
3ko0I-2e0iA:
0.0
3ko0J-2e0iA:
0.0		 3ko0A-2e0iA:
12.59
3ko0B-2e0iA:
12.59
3ko0I-2e0iA:
12.59
3ko0J-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 LEU A 288
LEU A 130
SER A 128
PHE A 129
ILE A 317
 None
 0.90A 3ko0A-2fqxA:
undetectable
3ko0B-2fqxA:
undetectable
3ko0I-2fqxA:
undetectable
3ko0J-2fqxA:
undetectable		 3ko0A-2fqxA:
13.92
3ko0B-2fqxA:
13.92
3ko0I-2fqxA:
13.92
3ko0J-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		5 ASP A 258
LEU A  65
ASP A   4
LEU A 333
ILE A 108
 None
 1.27A 3ko0A-2gwgA:
undetectable
3ko0B-2gwgA:
undetectable
3ko0I-2gwgA:
undetectable
3ko0J-2gwgA:
0.0		 3ko0A-2gwgA:
14.66
3ko0B-2gwgA:
14.66
3ko0I-2gwgA:
14.66
3ko0J-2gwgA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 SER A 198
LEU A 163
SER A 166
PHE A 168
ILE A 344
 None
None
CL  A1369 (-3.8A)
None
None
 1.27A 3ko0A-2ji4A:
undetectable
3ko0B-2ji4A:
undetectable
3ko0I-2ji4A:
undetectable
3ko0J-2ji4A:
undetectable		 3ko0A-2ji4A:
14.12
3ko0B-2ji4A:
14.12
3ko0I-2ji4A:
14.12
3ko0J-2ji4A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 845
LEU A 910
PHE A 909
ILE A 888
CYH A 892
 None
 0.92A 3ko0A-2ogvA:
undetectable
3ko0B-2ogvA:
undetectable
3ko0I-2ogvA:
undetectable
3ko0J-2ogvA:
undetectable		 3ko0A-2ogvA:
15.41
3ko0B-2ogvA:
15.41
3ko0I-2ogvA:
15.41
3ko0J-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20

(Homo sapiens) 		PF00270
(DEAD) 		5 PHE A  64
LEU A 121
ASP A 122
PHE A  82
ILE A 153
 None
None
None
ADP  A 300 (-4.4A)
None
 1.26A 3ko0A-2oxcA:
undetectable
3ko0B-2oxcA:
undetectable
3ko0I-2oxcA:
undetectable
3ko0J-2oxcA:
undetectable		 3ko0A-2oxcA:
19.37
3ko0B-2oxcA:
19.37
3ko0I-2oxcA:
19.37
3ko0J-2oxcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 ASP A 257
LEU A 117
LEU A  82
SER A  84
PHE A  86
 None
 1.18A 3ko0A-2q83A:
undetectable
3ko0B-2q83A:
undetectable
3ko0I-2q83A:
undetectable
3ko0J-2q83A:
undetectable		 3ko0A-2q83A:
15.38
3ko0B-2q83A:
15.38
3ko0I-2q83A:
15.38
3ko0J-2q83A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 LEU A 453
LEU A 499
SER A 501
PHE A 503
ILE A 506
 None
 1.26A 3ko0A-2qnaA:
undetectable
3ko0B-2qnaA:
undetectable
3ko0I-2qnaA:
undetectable
3ko0J-2qnaA:
undetectable		 3ko0A-2qnaA:
9.71
3ko0B-2qnaA:
9.71
3ko0I-2qnaA:
9.71
3ko0J-2qnaA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 PHE A 128
LEU A 217
ASP A 218
SER A 190
ILE A 325
 None
 0.96A 3ko0A-2qzxA:
undetectable
3ko0B-2qzxA:
undetectable
3ko0I-2qzxA:
undetectable
3ko0J-2qzxA:
undetectable		 3ko0A-2qzxA:
17.17
3ko0B-2qzxA:
17.17
3ko0I-2qzxA:
17.17
3ko0J-2qzxA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.15A 3ko0A-2v26A:
undetectable
3ko0B-2v26A:
undetectable
3ko0I-2v26A:
undetectable
3ko0J-2v26A:
undetectable		 3ko0A-2v26A:
9.24
3ko0B-2v26A:
9.24
3ko0I-2v26A:
9.24
3ko0J-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vri NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
NL63) 		PF01661
(Macro) 		5 LEU A 107
LEU A 134
SER A 136
PHE A 135
ILE A 139
 None
 1.21A 3ko0A-2vriA:
undetectable
3ko0B-2vriA:
undetectable
3ko0I-2vriA:
undetectable
3ko0J-2vriA:
undetectable		 3ko0A-2vriA:
21.43
3ko0B-2vriA:
21.43
3ko0I-2vriA:
21.43
3ko0J-2vriA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 ASP A 141
ASP A 402
LEU A 363
ILE A 398
PHE A 107
 None
 1.15A 3ko0A-2wn4A:
undetectable
3ko0B-2wn4A:
undetectable
3ko0I-2wn4A:
undetectable
3ko0J-2wn4A:
undetectable		 3ko0A-2wn4A:
13.10
3ko0B-2wn4A:
13.10
3ko0I-2wn4A:
13.10
3ko0J-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 SER A 543
PHE A 586
LEU A 593
LEU A 604
ILE A 517
 None
None
C  B 935 ( 3.7A)
None
C  B 935 ( 4.2A)
 1.19A 3ko0A-2zufA:
undetectable
3ko0B-2zufA:
undetectable
3ko0I-2zufA:
undetectable
3ko0J-2zufA:
undetectable		 3ko0A-2zufA:
8.35
3ko0B-2zufA:
8.35
3ko0I-2zufA:
8.35
3ko0J-2zufA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		5 PHE B  85
LEU B 106
LEU B  68
SER B  70
PHE B  71
 None
HEM  B 401 ( 4.5A)
None
HEM  B 401 ( 3.8A)
None
 1.18A 3ko0A-3a0gB:
undetectable
3ko0B-3a0gB:
undetectable
3ko0I-3a0gB:
undetectable
3ko0J-3a0gB:
undetectable		 3ko0A-3a0gB:
21.92
3ko0B-3a0gB:
21.92
3ko0I-3a0gB:
21.92
3ko0J-3a0gB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a69 FLAGELLAR HOOK
PROTEIN FLGE

(Salmonella
enterica) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07559
(FlaE) 		5 SER A  94
LEU A  72
ASP A  73
LEU A 107
ILE A 293
 None
 1.16A 3ko0A-3a69A:
undetectable
3ko0B-3a69A:
undetectable
3ko0I-3a69A:
undetectable
3ko0J-3a69A:
undetectable		 3ko0A-3a69A:
12.56
3ko0B-3a69A:
12.56
3ko0I-3a69A:
12.56
3ko0J-3a69A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 SER A 479
LEU A 577
LEU A 448
PHE A 444
ILE A 572
 None
 1.24A 3ko0A-3ctzA:
undetectable
3ko0B-3ctzA:
undetectable
3ko0I-3ctzA:
undetectable
3ko0J-3ctzA:
undetectable		 3ko0A-3ctzA:
9.50
3ko0B-3ctzA:
9.50
3ko0I-3ctzA:
9.50
3ko0J-3ctzA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 ASP X  18
SER X  11
SER X 239
ILE X 278
PHE X 259
 None
 1.24A 3ko0A-3e13X:
undetectable
3ko0B-3e13X:
undetectable
3ko0I-3e13X:
undetectable
3ko0J-3e13X:
undetectable		 3ko0A-3e13X:
16.67
3ko0B-3e13X:
16.67
3ko0I-3e13X:
16.67
3ko0J-3e13X:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 PHE A  81
LEU A  69
LEU A  25
PHE A  22
ILE A  49
 None
 1.21A 3ko0A-3e1kA:
undetectable
3ko0B-3e1kA:
undetectable
3ko0I-3e1kA:
undetectable
3ko0J-3e1kA:
undetectable		 3ko0A-3e1kA:
13.62
3ko0B-3e1kA:
13.62
3ko0I-3e1kA:
13.62
3ko0J-3e1kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 ASP A 164
SER A 171
PHE A 410
ILE A 395
PHE A 298
 None
 1.15A 3ko0A-3eafA:
undetectable
3ko0B-3eafA:
undetectable
3ko0I-3eafA:
undetectable
3ko0J-3eafA:
undetectable		 3ko0A-3eafA:
12.92
3ko0B-3eafA:
12.92
3ko0I-3eafA:
12.92
3ko0J-3eafA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2

(Homo sapiens) 		PF05527
(DUF758) 		5 SER A  52
LEU A  63
ASP A  62
LEU A  42
SER A  46
 None
 1.28A 3ko0A-3f4mA:
undetectable
3ko0B-3f4mA:
undetectable
3ko0I-3f4mA:
undetectable
3ko0J-3f4mA:
undetectable		 3ko0A-3f4mA:
23.93
3ko0B-3f4mA:
23.93
3ko0I-3f4mA:
23.93
3ko0J-3f4mA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 LEU A 154
LEU A 146
ILE A 122
CYH A 133
PHE A 132
 None
 1.23A 3ko0A-3fkdA:
undetectable
3ko0B-3fkdA:
undetectable
3ko0I-3fkdA:
undetectable
3ko0J-3fkdA:
undetectable		 3ko0A-3fkdA:
12.82
3ko0B-3fkdA:
12.82
3ko0I-3fkdA:
12.82
3ko0J-3fkdA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8w LACTOCOCCAL PROPHAGE
PS3 PROTEIN 05

(Staphylococcus
epidermidis) 		PF13420
(Acetyltransf_4) 		5 LEU A  69
LEU A 115
ILE A 103
CYH A  67
PHE A  87
 None
 1.20A 3ko0A-3g8wA:
undetectable
3ko0B-3g8wA:
undetectable
3ko0I-3g8wA:
undetectable
3ko0J-3g8wA:
undetectable		 3ko0A-3g8wA:
25.00
3ko0B-3g8wA:
25.00
3ko0I-3g8wA:
25.00
3ko0J-3g8wA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 312
LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 1.09A 3ko0A-3h11A:
undetectable
3ko0B-3h11A:
undetectable
3ko0I-3h11A:
undetectable
3ko0J-3h11A:
undetectable		 3ko0A-3h11A:
15.79
3ko0B-3h11A:
15.79
3ko0I-3h11A:
15.79
3ko0J-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		5 SER A 191
LEU A 203
LEU A 161
ILE A 166
CYH A 174
 None
 1.23A 3ko0A-3h7kA:
undetectable
3ko0B-3h7kA:
undetectable
3ko0I-3h7kA:
undetectable
3ko0J-3h7kA:
undetectable		 3ko0A-3h7kA:
14.13
3ko0B-3h7kA:
14.13
3ko0I-3h7kA:
14.13
3ko0J-3h7kA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		5 LEU A 109
ASP A 103
LEU A  60
SER A  61
ILE A  24
 None
 1.29A 3ko0A-3hoiA:
undetectable
3ko0B-3hoiA:
undetectable
3ko0I-3hoiA:
undetectable
3ko0J-3hoiA:
undetectable		 3ko0A-3hoiA:
19.19
3ko0B-3hoiA:
19.19
3ko0I-3hoiA:
19.19
3ko0J-3hoiA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 5 ASP A 172
PHE A 240
LEU A 181
SER A 178
ILE A  68
 None
 1.21A 3ko0A-3hwpA:
undetectable
3ko0B-3hwpA:
undetectable
3ko0I-3hwpA:
undetectable
3ko0J-3hwpA:
undetectable		 3ko0A-3hwpA:
15.77
3ko0B-3hwpA:
15.77
3ko0I-3hwpA:
15.77
3ko0J-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 PHE A 381
LEU A 437
ASP A 436
LEU A 416
ILE A 408
 None
None
NDG  A4701 ( 3.1A)
None
None
 1.19A 3ko0A-3i2tA:
undetectable
3ko0B-3i2tA:
undetectable
3ko0I-3i2tA:
undetectable
3ko0J-3i2tA:
undetectable		 3ko0A-3i2tA:
11.34
3ko0B-3i2tA:
11.34
3ko0I-3i2tA:
11.34
3ko0J-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2w SYNDAPIN

(Drosophila
melanogaster) 		PF00611
(FCH) 		5 LEU A 103
ASP A 106
LEU A 253
SER A 251
ILE A  99
 None
 1.23A 3ko0A-3i2wA:
undetectable
3ko0B-3i2wA:
undetectable
3ko0I-3i2wA:
undetectable
3ko0J-3i2wA:
undetectable		 3ko0A-3i2wA:
15.99
3ko0B-3i2wA:
15.99
3ko0I-3i2wA:
15.99
3ko0J-3i2wA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 ASP A 101
SER A  25
LEU A 115
LEU A  19
PHE A  48
 None
 1.08A 3ko0A-3jr3A:
undetectable
3ko0B-3jr3A:
undetectable
3ko0I-3jr3A:
undetectable
3ko0J-3jr3A:
undetectable		 3ko0A-3jr3A:
20.18
3ko0B-3jr3A:
20.18
3ko0I-3jr3A:
20.18
3ko0J-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		5 LEU A  79
ASP A 142
LEU A 170
PHE A 147
ILE A 103
 None
 1.18A 3ko0A-3k4zA:
undetectable
3ko0B-3k4zA:
undetectable
3ko0I-3k4zA:
undetectable
3ko0J-3k4zA:
undetectable		 3ko0A-3k4zA:
16.07
3ko0B-3k4zA:
16.07
3ko0I-3k4zA:
16.07
3ko0J-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4

(Homo sapiens) 		no annotation 5 SER A 377
LEU A 230
SER A 331
ILE A 254
PHE A 251
 None
 1.18A 3ko0A-3l15A:
undetectable
3ko0B-3l15A:
undetectable
3ko0I-3l15A:
undetectable
3ko0J-3l15A:
undetectable		 3ko0A-3l15A:
20.36
3ko0B-3l15A:
20.36
3ko0I-3l15A:
20.36
3ko0J-3l15A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 SER A 203
LEU A 272
LEU A 166
SER A 169
PHE A 170
 None
 0.94A 3ko0A-3mjoA:
0.8
3ko0B-3mjoA:
1.0
3ko0I-3mjoA:
0.7
3ko0J-3mjoA:
0.7		 3ko0A-3mjoA:
17.12
3ko0B-3mjoA:
17.12
3ko0I-3mjoA:
17.12
3ko0J-3mjoA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		5 ASP A 258
PHE A  83
LEU A 172
LEU A 249
PHE A 311
 None
 1.16A 3ko0A-3n8uA:
undetectable
3ko0B-3n8uA:
undetectable
3ko0I-3n8uA:
undetectable
3ko0J-3n8uA:
undetectable		 3ko0A-3n8uA:
14.11
3ko0B-3n8uA:
14.11
3ko0I-3n8uA:
14.11
3ko0J-3n8uA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		5 ASP A 205
LEU A 212
SER A 213
PHE A 211
ILE A 208
 None
None
None
None
DTD  A 248 ( 4.1A)
 1.24A 3ko0A-3oqvA:
undetectable
3ko0B-3oqvA:
undetectable
3ko0I-3oqvA:
undetectable
3ko0J-3oqvA:
undetectable		 3ko0A-3oqvA:
15.73
3ko0B-3oqvA:
15.73
3ko0I-3oqvA:
15.73
3ko0J-3oqvA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6b CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9) 		5 LEU A  99
ASP A 162
LEU A 190
PHE A 167
ILE A 123
 None
 1.28A 3ko0A-3p6bA:
undetectable
3ko0B-3p6bA:
undetectable
3ko0I-3p6bA:
undetectable
3ko0J-3p6bA:
undetectable		 3ko0A-3p6bA:
20.71
3ko0B-3p6bA:
20.71
3ko0I-3p6bA:
20.71
3ko0J-3p6bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph2 CYTOCHROME C6

(Phormidium
laminosum) 		PF13442
(Cytochrome_CBB3) 		5 PHE B  11
LEU B  79
ASP B  80
LEU B  37
ILE B  48
 None
None
None
None
HEM  B1087 ( 4.4A)
 1.22A 3ko0A-3ph2B:
undetectable
3ko0B-3ph2B:
undetectable
3ko0I-3ph2B:
undetectable
3ko0J-3ph2B:
undetectable		 3ko0A-3ph2B:
19.00
3ko0B-3ph2B:
19.00
3ko0I-3ph2B:
19.00
3ko0J-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 107
ASP A 111
SER A 310
PHE A 311
ILE A 276
 None
 1.09A 3ko0A-3r11A:
undetectable
3ko0B-3r11A:
undetectable
3ko0I-3r11A:
undetectable
3ko0J-3r11A:
undetectable		 3ko0A-3r11A:
12.40
3ko0B-3r11A:
12.40
3ko0I-3r11A:
12.40
3ko0J-3r11A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		5 PHE A 253
LEU A 223
ASP A 222
LEU A 203
ILE A 169
 None
 1.16A 3ko0A-3skvA:
undetectable
3ko0B-3skvA:
undetectable
3ko0I-3skvA:
undetectable
3ko0J-3skvA:
undetectable		 3ko0A-3skvA:
14.71
3ko0B-3skvA:
14.71
3ko0I-3skvA:
14.71
3ko0J-3skvA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		5 ASP A 170
LEU A 177
LEU A 341
SER A 343
ILE A 199
 None
 1.18A 3ko0A-3sqiA:
undetectable
3ko0B-3sqiA:
undetectable
3ko0I-3sqiA:
0.0
3ko0J-3sqiA:
undetectable		 3ko0A-3sqiA:
12.24
3ko0B-3sqiA:
12.24
3ko0I-3sqiA:
12.24
3ko0J-3sqiA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		5 ASP A 170
LEU A 177
LEU A 341
SER A 343
ILE A 199
 None
 1.26A 3ko0A-3t79A:
undetectable
3ko0B-3t79A:
undetectable
3ko0I-3t79A:
undetectable
3ko0J-3t79A:
undetectable		 3ko0A-3t79A:
13.68
3ko0B-3t79A:
13.68
3ko0I-3t79A:
13.68
3ko0J-3t79A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 PHE A 777
LEU A 435
ASP A 436
LEU A 431
ILE A 262
 EDO  A 795 ( 3.6A)
None
None
None
None
 0.83A 3ko0A-3tbkA:
undetectable
3ko0B-3tbkA:
undetectable
3ko0I-3tbkA:
undetectable
3ko0J-3tbkA:
undetectable		 3ko0A-3tbkA:
10.99
3ko0B-3tbkA:
10.99
3ko0I-3tbkA:
10.99
3ko0J-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 ASP A 132
LEU A 260
LEU A 324
SER A 321
ILE A 293
 None
 1.22A 3ko0A-3uduA:
0.6
3ko0B-3uduA:
0.6
3ko0I-3uduA:
0.7
3ko0J-3uduA:
0.6		 3ko0A-3uduA:
16.22
3ko0B-3uduA:
16.22
3ko0I-3uduA:
16.22
3ko0J-3uduA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 283
LEU A 277
ASP A 342
LEU A 325
ILE A 229
 None
 1.26A 3ko0A-3wdjA:
undetectable
3ko0B-3wdjA:
undetectable
3ko0I-3wdjA:
undetectable
3ko0J-3wdjA:
undetectable		 3ko0A-3wdjA:
9.15
3ko0B-3wdjA:
9.15
3ko0I-3wdjA:
9.15
3ko0J-3wdjA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 ASP A 325
LEU A 334
PHE A 333
ILE A 236
PHE A 264
 None
 1.10A 3ko0A-3wnpA:
undetectable
3ko0B-3wnpA:
undetectable
3ko0I-3wnpA:
undetectable
3ko0J-3wnpA:
undetectable		 3ko0A-3wnpA:
9.04
3ko0B-3wnpA:
9.04
3ko0I-3wnpA:
9.04
3ko0J-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		5 LEU A 336
ASP A 337
LEU A 281
PHE A 284
ILE A 334
 None
 1.26A 3ko0A-3wvsA:
undetectable
3ko0B-3wvsA:
undetectable
3ko0I-3wvsA:
undetectable
3ko0J-3wvsA:
undetectable		 3ko0A-3wvsA:
12.56
3ko0B-3wvsA:
12.56
3ko0I-3wvsA:
12.56
3ko0J-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ASP A 316
PHE A 352
LEU A  49
ASP A  97
PHE A  18
 GOL  A1548 (-3.5A)
None
None
None
None
 1.26A 3ko0A-4aieA:
undetectable
3ko0B-4aieA:
undetectable
3ko0I-4aieA:
undetectable
3ko0J-4aieA:
undetectable		 3ko0A-4aieA:
11.87
3ko0B-4aieA:
11.87
3ko0I-4aieA:
11.87
3ko0J-4aieA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.22A 3ko0A-4anjA:
undetectable
3ko0B-4anjA:
undetectable
3ko0I-4anjA:
undetectable
3ko0J-4anjA:
undetectable		 3ko0A-4anjA:
6.93
3ko0B-4anjA:
6.93
3ko0I-4anjA:
6.93
3ko0J-4anjA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 ASP A 351
ASP A 318
LEU A 332
PHE A 327
ILE A 325
 None
 1.14A 3ko0A-4bhdA:
undetectable
3ko0B-4bhdA:
undetectable
3ko0I-4bhdA:
undetectable
3ko0J-4bhdA:
undetectable		 3ko0A-4bhdA:
12.38
3ko0B-4bhdA:
12.38
3ko0I-4bhdA:
12.38
3ko0J-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 5 ASP A  70
PHE A 117
LEU A  84
LEU A 164
SER A 120
 None
 1.22A 3ko0A-4h5iA:
undetectable
3ko0B-4h5iA:
undetectable
3ko0I-4h5iA:
undetectable
3ko0J-4h5iA:
undetectable		 3ko0A-4h5iA:
15.69
3ko0B-4h5iA:
15.69
3ko0I-4h5iA:
15.69
3ko0J-4h5iA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.21A 3ko0A-4hwtA:
1.1
3ko0B-4hwtA:
1.2
3ko0I-4hwtA:
1.1
3ko0J-4hwtA:
1.0		 3ko0A-4hwtA:
14.49
3ko0B-4hwtA:
14.49
3ko0I-4hwtA:
14.49
3ko0J-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		5 LEU A 240
ASP A 241
LEU A  45
PHE A  66
ILE A  11
 None
 1.15A 3ko0A-4iwmA:
undetectable
3ko0B-4iwmA:
undetectable
3ko0I-4iwmA:
undetectable
3ko0J-4iwmA:
1.2		 3ko0A-4iwmA:
17.05
3ko0B-4iwmA:
17.05
3ko0I-4iwmA:
17.05
3ko0J-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		5 LEU A1480
ASP A1476
LEU A1524
SER A1523
ILE A1481
 None
 1.20A 3ko0A-4lnzA:
1.6
3ko0B-4lnzA:
1.7
3ko0I-4lnzA:
1.7
3ko0J-4lnzA:
1.6		 3ko0A-4lnzA:
14.90
3ko0B-4lnzA:
14.90
3ko0I-4lnzA:
14.90
3ko0J-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 PHE A 119
LEU A 129
LEU A  85
PHE A  92
ILE A  67
 None
 1.17A 3ko0A-4p53A:
undetectable
3ko0B-4p53A:
undetectable
3ko0I-4p53A:
undetectable
3ko0J-4p53A:
undetectable		 3ko0A-4p53A:
12.62
3ko0B-4p53A:
12.62
3ko0I-4p53A:
12.62
3ko0J-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 377
ASP A 405
LEU A 390
ILE A 382
CYH A 409
 None
 0.96A 3ko0A-4r5dA:
undetectable
3ko0B-4r5dA:
undetectable
3ko0I-4r5dA:
undetectable
3ko0J-4r5dA:
undetectable		 3ko0A-4r5dA:
10.93
3ko0B-4r5dA:
10.93
3ko0I-4r5dA:
10.93
3ko0J-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		5 PHE A 162
LEU A 114
ASP A 113
LEU A  95
ILE A 120
 None
 1.12A 3ko0A-4s1aA:
undetectable
3ko0B-4s1aA:
undetectable
3ko0I-4s1aA:
undetectable
3ko0J-4s1aA:
undetectable		 3ko0A-4s1aA:
18.98
3ko0B-4s1aA:
18.98
3ko0I-4s1aA:
18.98
3ko0J-4s1aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 ASP A 346
SER A 363
PHE A 420
SER A 368
ILE A 413
 None
 1.25A 3ko0A-4u3tA:
undetectable
3ko0B-4u3tA:
undetectable
3ko0I-4u3tA:
undetectable
3ko0J-4u3tA:
undetectable		 3ko0A-4u3tA:
15.76
3ko0B-4u3tA:
15.76
3ko0I-4u3tA:
15.76
3ko0J-4u3tA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 400
ASP A 401
LEU A 409
PHE A 408
ILE A 396
 None
 1.13A 3ko0A-4up7A:
undetectable
3ko0B-4up7A:
0.9
3ko0I-4up7A:
undetectable
3ko0J-4up7A:
undetectable		 3ko0A-4up7A:
9.51
3ko0B-4up7A:
9.51
3ko0I-4up7A:
9.51
3ko0J-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pyrococcus
horikoshii) 		PF01867
(Cas_Cas1) 		5 PHE A  65
LEU A   6
ASP A  39
LEU A  14
ILE A   8
 None
 1.17A 3ko0A-4wj0A:
undetectable
3ko0B-4wj0A:
undetectable
3ko0I-4wj0A:
undetectable
3ko0J-4wj0A:
undetectable		 3ko0A-4wj0A:
16.94
3ko0B-4wj0A:
16.94
3ko0I-4wj0A:
16.94
3ko0J-4wj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 856
ASP A 854
LEU A 819
PHE A 818
ILE A 845
 None
 1.26A 3ko0A-4wz9A:
undetectable
3ko0B-4wz9A:
undetectable
3ko0I-4wz9A:
undetectable
3ko0J-4wz9A:
undetectable		 3ko0A-4wz9A:
9.13
3ko0B-4wz9A:
9.13
3ko0I-4wz9A:
9.13
3ko0J-4wz9A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2830
ASP A2854
LEU A2842
SER A2844
PHE A2845
 None
 1.27A 3ko0A-4z37A:
undetectable
3ko0B-4z37A:
undetectable
3ko0I-4z37A:
undetectable
3ko0J-4z37A:
undetectable		 3ko0A-4z37A:
9.61
3ko0B-4z37A:
9.61
3ko0I-4z37A:
9.61
3ko0J-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 PHE A 627
LEU A 588
ASP A 587
LEU A 577
ILE A 573
 None
 1.10A 3ko0A-4z61A:
undetectable
3ko0B-4z61A:
undetectable
3ko0I-4z61A:
undetectable
3ko0J-4z61A:
undetectable		 3ko0A-4z61A:
10.84
3ko0B-4z61A:
10.84
3ko0I-4z61A:
10.84
3ko0J-4z61A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE A 159
LEU A 107
ASP A 130
LEU A  92
ILE A 112
 None
None
NAG  A 701 (-3.7A)
None
None
 1.27A 3ko0A-4z64A:
undetectable
3ko0B-4z64A:
undetectable
3ko0I-4z64A:
undetectable
3ko0J-4z64A:
undetectable		 3ko0A-4z64A:
11.79
3ko0B-4z64A:
11.79
3ko0I-4z64A:
11.79
3ko0J-4z64A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE A 617
LEU A 578
ASP A 577
LEU A 567
ILE A 563
 None
 1.13A 3ko0A-4z64A:
undetectable
3ko0B-4z64A:
undetectable
3ko0I-4z64A:
undetectable
3ko0J-4z64A:
undetectable		 3ko0A-4z64A:
11.79
3ko0B-4z64A:
11.79
3ko0I-4z64A:
11.79
3ko0J-4z64A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 5 SER A 613
LEU A 727
ASP A 728
LEU A 617
ILE A 724
 None
 1.21A 3ko0A-4zuzA:
undetectable
3ko0B-4zuzA:
undetectable
3ko0I-4zuzA:
undetectable
3ko0J-4zuzA:
undetectable		 3ko0A-4zuzA:
7.52
3ko0B-4zuzA:
7.52
3ko0I-4zuzA:
7.52
3ko0J-4zuzA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		5 SER A 599
LEU A 643
ASP A 642
LEU A 589
SER A 590
 None
 1.28A 3ko0A-5a01A:
undetectable
3ko0B-5a01A:
undetectable
3ko0I-5a01A:
undetectable
3ko0J-5a01A:
undetectable		 3ko0A-5a01A:
9.45
3ko0B-5a01A:
9.45
3ko0I-5a01A:
9.45
3ko0J-5a01A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		5 SER A  40
LEU A  56
ASP A  57
LEU A 126
PHE A 122
 DMS  A1314 ( 3.7A)
None
None
None
None
 1.19A 3ko0A-5advA:
undetectable
3ko0B-5advA:
undetectable
3ko0I-5advA:
undetectable
3ko0J-5advA:
undetectable		 3ko0A-5advA:
15.55
3ko0B-5advA:
15.55
3ko0I-5advA:
15.55
3ko0J-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 ASP B  16
LEU A 387
LEU B 168
SER B  83
PHE B  82
 EDO  B 205 (-3.6A)
None
None
None
None
 1.09A 3ko0A-5b8iB:
5.9
3ko0B-5b8iB:
6.3
3ko0I-5b8iB:
6.3
3ko0J-5b8iB:
6.2		 3ko0A-5b8iB:
19.54
3ko0B-5b8iB:
19.54
3ko0I-5b8iB:
19.54
3ko0J-5b8iB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		5 ASP E 237
LEU E 209
LEU E 285
PHE E 246
ILE E 213
 None
 1.15A 3ko0A-5esvE:
undetectable
3ko0B-5esvE:
undetectable
3ko0I-5esvE:
undetectable
3ko0J-5esvE:
undetectable		 3ko0A-5esvE:
20.39
3ko0B-5esvE:
20.39
3ko0I-5esvE:
20.39
3ko0J-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 ASP D 358
LEU D 382
LEU D 394
ILE D 401
CYH D 405
 None
 1.20A 3ko0A-5exrD:
undetectable
3ko0B-5exrD:
undetectable
3ko0I-5exrD:
undetectable
3ko0J-5exrD:
undetectable		 3ko0A-5exrD:
13.78
3ko0B-5exrD:
13.78
3ko0I-5exrD:
13.78
3ko0J-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 LEU A 148
LEU A  60
ILE A  78
CYH A  80
PHE A 155
 None
 1.28A 3ko0A-5heiA:
undetectable
3ko0B-5heiA:
undetectable
3ko0I-5heiA:
undetectable
3ko0J-5heiA:
undetectable		 3ko0A-5heiA:
19.84
3ko0B-5heiA:
19.84
3ko0I-5heiA:
19.84
3ko0J-5heiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 ASP A 240
SER A  51
LEU A 271
LEU A 230
ILE A 105
 SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
None
None
None
 1.10A 3ko0A-5hxsA:
0.2
3ko0B-5hxsA:
undetectable
3ko0I-5hxsA:
undetectable
3ko0J-5hxsA:
undetectable		 3ko0A-5hxsA:
12.62
3ko0B-5hxsA:
12.62
3ko0I-5hxsA:
12.62
3ko0J-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 SER A 164
LEU A  94
SER A  95
PHE A  69
ILE A  74
 None
 1.13A 3ko0A-5hyhA:
undetectable
3ko0B-5hyhA:
undetectable
3ko0I-5hyhA:
undetectable
3ko0J-5hyhA:
undetectable		 3ko0A-5hyhA:
14.19
3ko0B-5hyhA:
14.19
3ko0I-5hyhA:
14.19
3ko0J-5hyhA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 ASP B 138
LEU B 164
LEU B 143
SER B 134
ILE B 183
 None
 1.13A 3ko0A-5k1cB:
undetectable
3ko0B-5k1cB:
undetectable
3ko0I-5k1cB:
undetectable
3ko0J-5k1cB:
undetectable		 3ko0A-5k1cB:
9.96
3ko0B-5k1cB:
9.96
3ko0I-5k1cB:
9.96
3ko0J-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ASP A 346
SER A 363
PHE A 420
SER A 368
ILE A 413
 None
 1.27A 3ko0A-5kshA:
undetectable
3ko0B-5kshA:
undetectable
3ko0I-5kshA:
undetectable
3ko0J-5kshA:
undetectable		 3ko0A-5kshA:
10.70
3ko0B-5kshA:
10.70
3ko0I-5kshA:
10.70
3ko0J-5kshA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 5 ASP A 189
LEU A  42
LEU A 199
PHE A 198
ILE A  48
 None
 1.28A 3ko0A-5n72A:
undetectable
3ko0B-5n72A:
undetectable
3ko0I-5n72A:
undetectable
3ko0J-5n72A:
undetectable		 3ko0A-5n72A:
14.02
3ko0B-5n72A:
14.02
3ko0I-5n72A:
14.02
3ko0J-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 5 ASP A 189
LEU A 199
LEU A  42
PHE A  41
ILE A 175
 None
 1.24A 3ko0A-5n72A:
undetectable
3ko0B-5n72A:
undetectable
3ko0I-5n72A:
undetectable
3ko0J-5n72A:
undetectable		 3ko0A-5n72A:
14.02
3ko0B-5n72A:
14.02
3ko0I-5n72A:
14.02
3ko0J-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 5 PHE A  75
LEU A 107
ASP A 108
LEU A 129
ILE A 104
 None
 1.12A 3ko0A-5ubvA:
undetectable
3ko0B-5ubvA:
undetectable
3ko0I-5ubvA:
undetectable
3ko0J-5ubvA:
undetectable		 3ko0A-5ubvA:
21.05
3ko0B-5ubvA:
21.05
3ko0I-5ubvA:
21.05
3ko0J-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 ASP B  72
LEU B 111
ASP B 109
SER B 145
ILE B 150
 None
 1.08A 3ko0A-5y3rB:
undetectable
3ko0B-5y3rB:
undetectable
3ko0I-5y3rB:
undetectable
3ko0J-5y3rB:
undetectable		 3ko0A-5y3rB:
11.39
3ko0B-5y3rB:
11.39
3ko0I-5y3rB:
11.39
3ko0J-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 ASP A 386
SER A 333
LEU A 310
LEU A 329
ILE A 308
 None
 1.22A 3ko0A-6bbpA:
undetectable
3ko0B-6bbpA:
undetectable
3ko0I-6bbpA:
undetectable
3ko0J-6bbpA:
undetectable		 3ko0A-6bbpA:
20.56
3ko0B-6bbpA:
20.56
3ko0I-6bbpA:
20.56
3ko0J-6bbpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bni LYSINE--TRNA LIGASE

(Cryptosporidium
parvum) 		no annotation 5 PHE A  70
LEU A  76
SER A  98
PHE A 156
ILE A 118
 None
 1.28A 3ko0A-6bniA:
undetectable
3ko0B-6bniA:
1.7
3ko0I-6bniA:
undetectable
3ko0J-6bniA:
1.6		 3ko0A-6bniA:
18.52
3ko0B-6bniA:
18.52
3ko0I-6bniA:
18.52
3ko0J-6bniA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
 None
 1.08A 3ko0A-6evjB:
undetectable
3ko0B-6evjB:
undetectable
3ko0I-6evjB:
undetectable
3ko0J-6evjB:
undetectable		 3ko0A-6evjB:
17.92
3ko0B-6evjB:
17.92
3ko0I-6evjB:
17.92
3ko0J-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezn DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT WBP1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU G 110
LEU G 238
SER G 235
PHE G 237
ILE G 232
 None
 1.27A 3ko0A-6eznG:
undetectable
3ko0B-6eznG:
undetectable
3ko0I-6eznG:
undetectable
3ko0J-6eznG:
undetectable		 3ko0A-6eznG:
27.17
3ko0B-6eznG:
27.17
3ko0I-6eznG:
27.17
3ko0J-6eznG:
27.17