SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_J_TFPJ202
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ac5 | KEX1(DELTA)P (Saccharomycescerevisiae) |
PF00450(Peptidase_S10) | 5 | PHE A 159LEU A 205ASP A 204LEU A 172ILE A 189 | None | 1.29A | 3ko0A-1ac5A:undetectable3ko0B-1ac5A:0.03ko0I-1ac5A:0.03ko0J-1ac5A:0.0 | 3ko0A-1ac5A:13.143ko0B-1ac5A:13.143ko0I-1ac5A:13.143ko0J-1ac5A:13.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ag9 | FLAVODOXIN (Escherichiacoli) |
PF00258(Flavodoxin_1) | 5 | SER A 130ASP A 145LEU A 142PHE A 86ILE A 18 | None | 1.24A | 3ko0A-1ag9A:undetectable3ko0B-1ag9A:undetectable3ko0I-1ag9A:undetectable3ko0J-1ag9A:undetectable | 3ko0A-1ag9A:22.703ko0B-1ag9A:22.703ko0I-1ag9A:22.703ko0J-1ag9A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czk | FLAVODOXIN (Synechococcuselongatus) |
PF00258(Flavodoxin_1) | 5 | SER A 130ASP A 144LEU A 141PHE A 86ILE A 17 | None | 1.23A | 3ko0A-1czkA:undetectable3ko0B-1czkA:undetectable3ko0I-1czkA:undetectable3ko0J-1czkA:undetectable | 3ko0A-1czkA:21.023ko0B-1czkA:21.023ko0I-1czkA:21.023ko0J-1czkA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gy8 | UDP-GALACTOSE4-EPIMERASE (Trypanosomabrucei) |
PF01370(Epimerase) | 5 | ASP A 116LEU A 125LEU A 82PHE A 81CYH A 99 | NoneNoneNoneNoneNAD A1382 (-4.5A) | 1.14A | 3ko0A-1gy8A:undetectable3ko0B-1gy8A:undetectable3ko0I-1gy8A:undetectable3ko0J-1gy8A:undetectable | 3ko0A-1gy8A:13.923ko0B-1gy8A:13.923ko0I-1gy8A:13.923ko0J-1gy8A:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ig8 | HEXOKINASE PII (Saccharomycescerevisiae) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | LEU A 135LEU A 192PHE A 155ILE A 85PHE A 82 | None | 1.27A | 3ko0A-1ig8A:undetectable3ko0B-1ig8A:0.03ko0I-1ig8A:0.03ko0J-1ig8A:0.0 | 3ko0A-1ig8A:12.323ko0B-1ig8A:12.323ko0I-1ig8A:12.323ko0J-1ig8A:12.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1imv | PIGMENTEPITHELIUM-DERIVEDFACTOR (Homo sapiens) |
PF00079(Serpin) | 5 | SER A 184PHE A 323ASP A 319LEU A 314ILE A 83 | None | 1.26A | 3ko0A-1imvA:undetectable3ko0B-1imvA:undetectable3ko0I-1imvA:undetectable3ko0J-1imvA:undetectable | 3ko0A-1imvA:13.283ko0B-1imvA:13.283ko0I-1imvA:13.283ko0J-1imvA:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jn1 | 2C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Haemophilusinfluenzae) |
PF02542(YgbB) | 5 | ASP A 73LEU A 45LEU A 121PHE A 82ILE A 49 | None | 1.17A | 3ko0A-1jn1A:undetectable3ko0B-1jn1A:undetectable3ko0I-1jn1A:undetectable3ko0J-1jn1A:undetectable | 3ko0A-1jn1A:20.673ko0B-1jn1A:20.673ko0I-1jn1A:20.673ko0J-1jn1A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mfw | DOUBLECORTIN-LIKEKINASE (N-TERMINALDOMAIN) (Homo sapiens) |
PF03607(DCX) | 5 | LEU A 123ASP A 121LEU A 87PHE A 81ILE A 76 | None | 1.21A | 3ko0A-1mfwA:undetectable3ko0B-1mfwA:undetectable3ko0I-1mfwA:undetectable3ko0J-1mfwA:undetectable | 3ko0A-1mfwA:21.433ko0B-1mfwA:21.433ko0I-1mfwA:21.433ko0J-1mfwA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pz3 | ALPHA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF06964(Alpha-L-AF_C) | 5 | ASP A 482ASP A 439LEU A 436SER A 486ILE A 423 | None | 1.18A | 3ko0A-1pz3A:undetectable3ko0B-1pz3A:undetectable3ko0I-1pz3A:undetectable3ko0J-1pz3A:undetectable | 3ko0A-1pz3A:12.173ko0B-1pz3A:12.173ko0I-1pz3A:12.173ko0J-1pz3A:12.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pzt | BETA-1,4-GALACTOSYLTRANSFERASE 1 (Bos taurus) |
PF02709(Glyco_transf_7C)PF13733(Glyco_transf_7N) | 5 | LEU A 325LEU A 296SER A 297PHE A 301ILE A 304 | None | 1.07A | 3ko0A-1pztA:undetectable3ko0B-1pztA:undetectable3ko0I-1pztA:undetectable3ko0J-1pztA:undetectable | 3ko0A-1pztA:17.803ko0B-1pztA:17.803ko0I-1pztA:17.803ko0J-1pztA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3b | ENDONUCLEASE VIII (Escherichiacoli) |
PF01149(Fapy_DNA_glyco)PF06827(zf-FPG_IleRS)PF06831(H2TH) | 5 | ASP A 24LEU A 64LEU A 32PHE A 29ILE A 108 | None | 1.25A | 3ko0A-1q3bA:1.43ko0B-1q3bA:1.53ko0I-1q3bA:1.43ko0J-1q3bA:1.4 | 3ko0A-1q3bA:17.053ko0B-1q3bA:17.053ko0I-1q3bA:17.053ko0J-1q3bA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vp4 | AMINOTRANSFERASE,PUTATIVE (Thermotogamaritima) |
PF00155(Aminotran_1_2) | 5 | ASP A 277SER A 280LEU A 110ASP A 111LEU A 243 | None | 1.02A | 3ko0A-1vp4A:undetectable3ko0B-1vp4A:0.03ko0I-1vp4A:0.03ko0J-1vp4A:0.0 | 3ko0A-1vp4A:13.443ko0B-1vp4A:13.443ko0I-1vp4A:13.443ko0J-1vp4A:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wlg | FLAGELLAR HOOKPROTEIN FLGE (Salmonellaenterica) |
PF07559(FlaE) | 5 | SER A 94LEU A 72ASP A 73LEU A 107ILE A 293 | None | 1.16A | 3ko0A-1wlgA:undetectable3ko0B-1wlgA:undetectable3ko0I-1wlgA:undetectable3ko0J-1wlgA:undetectable | 3ko0A-1wlgA:17.693ko0B-1wlgA:17.693ko0I-1wlgA:17.693ko0J-1wlgA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1woz | 177AA LONG CONSERVEDHYPOTHETICAL PROTEIN(ST1454) (Sulfurisphaeratokodaii) |
PF01923(Cob_adeno_trans) | 5 | LEU A 31ASP A 32LEU A 68SER A 69ILE A 64 | POG A 201 ( 4.7A)POG A 201 ( 4.6A)NoneNoneNone | 1.18A | 3ko0A-1wozA:1.33ko0B-1wozA:0.93ko0I-1wozA:1.03ko0J-1wozA:0.9 | 3ko0A-1wozA:20.573ko0B-1wozA:20.573ko0I-1wozA:20.573ko0J-1wozA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9e | HMG-COA SYNTHASE (Enterococcusfaecalis) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 5 | LEU A 303LEU A 285SER A 266ILE A 301PHE A 224 | None | 1.12A | 3ko0A-1x9eA:undetectable3ko0B-1x9eA:0.03ko0I-1x9eA:0.03ko0J-1x9eA:0.0 | 3ko0A-1x9eA:14.443ko0B-1x9eA:14.443ko0I-1x9eA:14.443ko0J-1x9eA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzm | PUTATIVEDEOXYRIBONUCLEASEYJJV (Escherichiacoli) |
PF01026(TatD_DNase) | 5 | ASP A 13LEU A 25SER A 24ILE A 36CYH A 10 | None | 1.17A | 3ko0A-1zzmA:undetectable3ko0B-1zzmA:0.03ko0I-1zzmA:0.03ko0J-1zzmA:0.0 | 3ko0A-1zzmA:14.893ko0B-1zzmA:14.893ko0I-1zzmA:14.893ko0J-1zzmA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4k | PHOSPHORIBOSYLPYROPHOSPHATESYNTHETASE-ASSOCIATED PROTEIN 1 (Homo sapiens) |
PF13793(Pribosyltran_N)PF14572(Pribosyl_synth) | 5 | SER A 186LEU A 151SER A 154PHE A 156ILE A 331 | None | 1.23A | 3ko0A-2c4kA:undetectable3ko0B-2c4kA:undetectable3ko0I-2c4kA:undetectable3ko0J-2c4kA:undetectable | 3ko0A-2c4kA:12.833ko0B-2c4kA:12.833ko0I-2c4kA:12.833ko0J-2c4kA:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c5u | RNA LIGASE (Escherichiavirus T4) |
PF09511(RNA_lig_T4_1) | 5 | LEU A 274ASP A 273LEU A 262ILE A 288PHE A 77 | NoneAPC A1375 ( 4.3A)NoneNoneNone | 1.29A | 3ko0A-2c5uA:1.63ko0B-2c5uA:0.03ko0I-2c5uA:1.53ko0J-2c5uA:undetectable | 3ko0A-2c5uA:14.403ko0B-2c5uA:14.403ko0I-2c5uA:14.403ko0J-2c5uA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0i | 432AA LONGHYPOTHETICALDEOXYRIBODIPYRIMIDINE PHOTOLYASE (Sulfurisphaeratokodaii) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 5 | SER A 168LEU A 59LEU A 175ILE A 55PHE A 7 | None | 1.16A | 3ko0A-2e0iA:undetectable3ko0B-2e0iA:0.03ko0I-2e0iA:0.03ko0J-2e0iA:0.0 | 3ko0A-2e0iA:12.593ko0B-2e0iA:12.593ko0I-2e0iA:12.593ko0J-2e0iA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fqx | MEMBRANE LIPOPROTEINTMPC (Treponemapallidum) |
PF02608(Bmp) | 5 | LEU A 288LEU A 130SER A 128PHE A 129ILE A 317 | None | 0.90A | 3ko0A-2fqxA:undetectable3ko0B-2fqxA:undetectable3ko0I-2fqxA:undetectable3ko0J-2fqxA:undetectable | 3ko0A-2fqxA:13.923ko0B-2fqxA:13.923ko0I-2fqxA:13.923ko0J-2fqxA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwg | 4-OXALOMESACONATEHYDRATASE (Rhodopseudomonaspalustris) |
PF04909(Amidohydro_2) | 5 | ASP A 258LEU A 65ASP A 4LEU A 333ILE A 108 | None | 1.27A | 3ko0A-2gwgA:undetectable3ko0B-2gwgA:undetectable3ko0I-2gwgA:undetectable3ko0J-2gwgA:0.0 | 3ko0A-2gwgA:14.663ko0B-2gwgA:14.663ko0I-2gwgA:14.663ko0J-2gwgA:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ji4 | PHOSPHORIBOSYLPYROPHOSPHATESYNTHETASE-ASSOCIATED PROTEIN 2 (Homo sapiens) |
PF13793(Pribosyltran_N)PF14572(Pribosyl_synth) | 5 | SER A 198LEU A 163SER A 166PHE A 168ILE A 344 | NoneNone CL A1369 (-3.8A)NoneNone | 1.27A | 3ko0A-2ji4A:undetectable3ko0B-2ji4A:undetectable3ko0I-2ji4A:undetectable3ko0J-2ji4A:undetectable | 3ko0A-2ji4A:14.123ko0B-2ji4A:14.123ko0I-2ji4A:14.123ko0J-2ji4A:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 845LEU A 910PHE A 909ILE A 888CYH A 892 | None | 0.92A | 3ko0A-2ogvA:undetectable3ko0B-2ogvA:undetectable3ko0I-2ogvA:undetectable3ko0J-2ogvA:undetectable | 3ko0A-2ogvA:15.413ko0B-2ogvA:15.413ko0I-2ogvA:15.413ko0J-2ogvA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oxc | PROBABLEATP-DEPENDENT RNAHELICASE DDX20 (Homo sapiens) |
PF00270(DEAD) | 5 | PHE A 64LEU A 121ASP A 122PHE A 82ILE A 153 | NoneNoneNoneADP A 300 (-4.4A)None | 1.26A | 3ko0A-2oxcA:undetectable3ko0B-2oxcA:undetectable3ko0I-2oxcA:undetectable3ko0J-2oxcA:undetectable | 3ko0A-2oxcA:19.373ko0B-2oxcA:19.373ko0I-2oxcA:19.373ko0J-2oxcA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q83 | YTAA PROTEIN (Bacillussubtilis) |
PF01636(APH) | 5 | ASP A 257LEU A 117LEU A 82SER A 84PHE A 86 | None | 1.18A | 3ko0A-2q83A:undetectable3ko0B-2q83A:undetectable3ko0I-2q83A:undetectable3ko0J-2q83A:undetectable | 3ko0A-2q83A:15.383ko0B-2q83A:15.383ko0I-2q83A:15.383ko0J-2q83A:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qna | IMPORTIN SUBUNITBETA-1 (Homo sapiens) |
PF13513(HEAT_EZ) | 5 | LEU A 453LEU A 499SER A 501PHE A 503ILE A 506 | None | 1.26A | 3ko0A-2qnaA:undetectable3ko0B-2qnaA:undetectable3ko0I-2qnaA:undetectable3ko0J-2qnaA:undetectable | 3ko0A-2qnaA:9.713ko0B-2qnaA:9.713ko0I-2qnaA:9.713ko0J-2qnaA:9.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzx | CANDIDAPEPSIN-5 (Candidaalbicans) |
PF00026(Asp) | 5 | PHE A 128LEU A 217ASP A 218SER A 190ILE A 325 | None | 0.96A | 3ko0A-2qzxA:undetectable3ko0B-2qzxA:undetectable3ko0I-2qzxA:undetectable3ko0J-2qzxA:undetectable | 3ko0A-2qzxA:17.173ko0B-2qzxA:17.173ko0I-2qzxA:17.173ko0J-2qzxA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v26 | MYOSIN VI (Sus scrofa) |
PF00063(Myosin_head) | 5 | PHE A 751ASP A 748LEU A 738ILE A 769PHE A 705 | None | 1.15A | 3ko0A-2v26A:undetectable3ko0B-2v26A:undetectable3ko0I-2v26A:undetectable3ko0J-2v26A:undetectable | 3ko0A-2v26A:9.243ko0B-2v26A:9.243ko0I-2v26A:9.243ko0J-2v26A:9.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vri | NON-STRUCTURALPROTEIN 3 (HumancoronavirusNL63) |
PF01661(Macro) | 5 | LEU A 107LEU A 134SER A 136PHE A 135ILE A 139 | None | 1.21A | 3ko0A-2vriA:undetectable3ko0B-2vriA:undetectable3ko0I-2vriA:undetectable3ko0J-2vriA:undetectable | 3ko0A-2vriA:21.433ko0B-2vriA:21.433ko0I-2vriA:21.433ko0J-2vriA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wn4 | ADP-RIBOSYLTRANSFERASE ENZYMATICCOMPONENT (Clostridioidesdifficile) |
PF03496(ADPrib_exo_Tox) | 5 | ASP A 141ASP A 402LEU A 363ILE A 398PHE A 107 | None | 1.15A | 3ko0A-2wn4A:undetectable3ko0B-2wn4A:undetectable3ko0I-2wn4A:undetectable3ko0J-2wn4A:undetectable | 3ko0A-2wn4A:13.103ko0B-2wn4A:13.103ko0I-2wn4A:13.103ko0J-2wn4A:13.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zuf | ARGINYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 5 | SER A 543PHE A 586LEU A 593LEU A 604ILE A 517 | NoneNone C B 935 ( 3.7A)None C B 935 ( 4.2A) | 1.19A | 3ko0A-2zufA:undetectable3ko0B-2zufA:undetectable3ko0I-2zufA:undetectable3ko0J-2zufA:undetectable | 3ko0A-2zufA:8.353ko0B-2zufA:8.353ko0I-2zufA:8.353ko0J-2zufA:8.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0g | HEMOGLOBIN SUBUNITBETA (Cavia porcellus) |
PF00042(Globin) | 5 | PHE B 85LEU B 106LEU B 68SER B 70PHE B 71 | NoneHEM B 401 ( 4.5A)NoneHEM B 401 ( 3.8A)None | 1.18A | 3ko0A-3a0gB:undetectable3ko0B-3a0gB:undetectable3ko0I-3a0gB:undetectable3ko0J-3a0gB:undetectable | 3ko0A-3a0gB:21.923ko0B-3a0gB:21.923ko0I-3a0gB:21.923ko0J-3a0gB:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a69 | FLAGELLAR HOOKPROTEIN FLGE (Salmonellaenterica) |
PF00460(Flg_bb_rod)PF06429(Flg_bbr_C)PF07559(FlaE) | 5 | SER A 94LEU A 72ASP A 73LEU A 107ILE A 293 | None | 1.16A | 3ko0A-3a69A:undetectable3ko0B-3a69A:undetectable3ko0I-3a69A:undetectable3ko0J-3a69A:undetectable | 3ko0A-3a69A:12.563ko0B-3a69A:12.563ko0I-3a69A:12.563ko0J-3a69A:12.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctz | XAA-PROAMINOPEPTIDASE 1 (Homo sapiens) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 5 | SER A 479LEU A 577LEU A 448PHE A 444ILE A 572 | None | 1.24A | 3ko0A-3ctzA:undetectable3ko0B-3ctzA:undetectable3ko0I-3ctzA:undetectable3ko0J-3ctzA:undetectable | 3ko0A-3ctzA:9.503ko0B-3ctzA:9.503ko0I-3ctzA:9.503ko0J-3ctzA:9.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e13 | PUTATIVE IRON-UPTAKEABC TRANSPORTSYSTEM,PERIPLASMICIRON-BINDING PROTEIN (Campylobacterjejuni) |
PF13343(SBP_bac_6) | 5 | ASP X 18SER X 11SER X 239ILE X 278PHE X 259 | None | 1.24A | 3ko0A-3e13X:undetectable3ko0B-3e13X:undetectable3ko0I-3e13X:undetectable3ko0J-3e13X:undetectable | 3ko0A-3e13X:16.673ko0B-3e13X:16.673ko0I-3e13X:16.673ko0J-3e13X:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1k | GALACTOSE/LACTOSEMETABOLISMREGULATORY PROTEINGAL80 (Kluyveromyceslactis) |
PF01408(GFO_IDH_MocA) | 5 | PHE A 81LEU A 69LEU A 25PHE A 22ILE A 49 | None | 1.21A | 3ko0A-3e1kA:undetectable3ko0B-3e1kA:undetectable3ko0I-3e1kA:undetectable3ko0J-3e1kA:undetectable | 3ko0A-3e1kA:13.623ko0B-3e1kA:13.623ko0I-3e1kA:13.623ko0J-3e1kA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eaf | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (Aeropyrumpernix) |
PF13458(Peripla_BP_6) | 5 | ASP A 164SER A 171PHE A 410ILE A 395PHE A 298 | None | 1.15A | 3ko0A-3eafA:undetectable3ko0B-3eafA:undetectable3ko0I-3eafA:undetectable3ko0J-3eafA:undetectable | 3ko0A-3eafA:12.923ko0B-3eafA:12.923ko0I-3eafA:12.923ko0J-3eafA:12.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f4m | TUMOR NECROSISFACTOR,ALPHA-INDUCEDPROTEIN 8-LIKEPROTEIN 2 (Homo sapiens) |
PF05527(DUF758) | 5 | SER A 52LEU A 63ASP A 62LEU A 42SER A 46 | None | 1.28A | 3ko0A-3f4mA:undetectable3ko0B-3f4mA:undetectable3ko0I-3f4mA:undetectable3ko0J-3f4mA:undetectable | 3ko0A-3f4mA:23.933ko0B-3f4mA:23.933ko0I-3f4mA:23.933ko0J-3f4mA:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkd | L-THREONINE-O-3-PHOSPHATE DECARBOXYLASE (Porphyromonasgingivalis) |
PF00155(Aminotran_1_2) | 5 | LEU A 154LEU A 146ILE A 122CYH A 133PHE A 132 | None | 1.23A | 3ko0A-3fkdA:undetectable3ko0B-3fkdA:undetectable3ko0I-3fkdA:undetectable3ko0J-3fkdA:undetectable | 3ko0A-3fkdA:12.823ko0B-3fkdA:12.823ko0I-3fkdA:12.823ko0J-3fkdA:12.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8w | LACTOCOCCAL PROPHAGEPS3 PROTEIN 05 (Staphylococcusepidermidis) |
PF13420(Acetyltransf_4) | 5 | LEU A 69LEU A 115ILE A 103CYH A 67PHE A 87 | None | 1.20A | 3ko0A-3g8wA:undetectable3ko0B-3g8wA:undetectable3ko0I-3g8wA:undetectable3ko0J-3g8wA:undetectable | 3ko0A-3g8wA:25.003ko0B-3g8wA:25.003ko0I-3g8wA:25.003ko0J-3g8wA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h11 | CASP8 AND FADD-LIKEAPOPTOSIS REGULATOR (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | LEU A 312LEU A 293SER A 290ILE A 257CYH A 259 | None | 1.09A | 3ko0A-3h11A:undetectable3ko0B-3h11A:undetectable3ko0I-3h11A:undetectable3ko0J-3h11A:undetectable | 3ko0A-3h11A:15.793ko0B-3h11A:15.793ko0I-3h11A:15.793ko0J-3h11A:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7k | AGMATINE DEIMINASE (Arabidopsisthaliana) |
PF04371(PAD_porph) | 5 | SER A 191LEU A 203LEU A 161ILE A 166CYH A 174 | None | 1.23A | 3ko0A-3h7kA:undetectable3ko0B-3h7kA:undetectable3ko0I-3h7kA:undetectable3ko0J-3h7kA:undetectable | 3ko0A-3h7kA:14.133ko0B-3h7kA:14.133ko0I-3h7kA:14.133ko0J-3h7kA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hoi | FMN-DEPENDENTNITROREDUCTASEBF3017 (Bacteroidesfragilis) |
PF00881(Nitroreductase) | 5 | LEU A 109ASP A 103LEU A 60SER A 61ILE A 24 | None | 1.29A | 3ko0A-3hoiA:undetectable3ko0B-3hoiA:undetectable3ko0I-3hoiA:undetectable3ko0J-3hoiA:undetectable | 3ko0A-3hoiA:19.193ko0B-3hoiA:19.193ko0I-3hoiA:19.193ko0J-3hoiA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hwp | PHLG (Pseudomonasprotegens) |
no annotation | 5 | ASP A 172PHE A 240LEU A 181SER A 178ILE A 68 | None | 1.21A | 3ko0A-3hwpA:undetectable3ko0B-3hwpA:undetectable3ko0I-3hwpA:undetectable3ko0J-3hwpA:undetectable | 3ko0A-3hwpA:15.773ko0B-3hwpA:15.773ko0I-3hwpA:15.773ko0J-3hwpA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i2t | EPIDERMAL GROWTHFACTOR RECEPTOR,ISOFORM A (Drosophilamelanogaster) |
PF00757(Furin-like)PF01030(Recep_L_domain)PF14843(GF_recep_IV) | 5 | PHE A 381LEU A 437ASP A 436LEU A 416ILE A 408 | NoneNoneNDG A4701 ( 3.1A)NoneNone | 1.19A | 3ko0A-3i2tA:undetectable3ko0B-3i2tA:undetectable3ko0I-3i2tA:undetectable3ko0J-3i2tA:undetectable | 3ko0A-3i2tA:11.343ko0B-3i2tA:11.343ko0I-3i2tA:11.343ko0J-3i2tA:11.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i2w | SYNDAPIN (Drosophilamelanogaster) |
PF00611(FCH) | 5 | LEU A 103ASP A 106LEU A 253SER A 251ILE A 99 | None | 1.23A | 3ko0A-3i2wA:undetectable3ko0B-3i2wA:undetectable3ko0I-3i2wA:undetectable3ko0J-3i2wA:undetectable | 3ko0A-3i2wA:15.993ko0B-3i2wA:15.993ko0I-3i2wA:15.993ko0J-3i2wA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jr3 | NAD-DEPENDENTDEACETYLASE (Thermotogamaritima) |
PF02146(SIR2) | 5 | ASP A 101SER A 25LEU A 115LEU A 19PHE A 48 | None | 1.08A | 3ko0A-3jr3A:undetectable3ko0B-3jr3A:undetectable3ko0I-3jr3A:undetectable3ko0J-3jr3A:undetectable | 3ko0A-3jr3A:20.183ko0B-3jr3A:20.183ko0I-3jr3A:20.183ko0J-3jr3A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k4z | GLYCOSIDE HYDROLASEFAMILY 9 (Ruminiclostridiumthermocellum) |
PF02018(CBM_4_9)PF02927(CelD_N) | 5 | LEU A 79ASP A 142LEU A 170PHE A 147ILE A 103 | None | 1.18A | 3ko0A-3k4zA:undetectable3ko0B-3k4zA:undetectable3ko0I-3k4zA:undetectable3ko0J-3k4zA:undetectable | 3ko0A-3k4zA:16.073ko0B-3k4zA:16.073ko0I-3k4zA:16.073ko0J-3k4zA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l15 | TRANSCRIPTIONALENHANCER FACTORTEF-4 (Homo sapiens) |
no annotation | 5 | SER A 377LEU A 230SER A 331ILE A 254PHE A 251 | None | 1.18A | 3ko0A-3l15A:undetectable3ko0B-3l15A:undetectable3ko0I-3l15A:undetectable3ko0J-3l15A:undetectable | 3ko0A-3l15A:20.363ko0B-3l15A:20.363ko0I-3l15A:20.363ko0J-3l15A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mjo | RIBONUCLEOTIDEREDUCTASE SUBUNITR2F (Corynebacteriumammoniagenes) |
PF00268(Ribonuc_red_sm) | 5 | SER A 203LEU A 272LEU A 166SER A 169PHE A 170 | None | 0.94A | 3ko0A-3mjoA:0.83ko0B-3mjoA:1.03ko0I-3mjoA:0.73ko0J-3mjoA:0.7 | 3ko0A-3mjoA:17.123ko0B-3mjoA:17.123ko0I-3mjoA:17.123ko0J-3mjoA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n8u | IMELYSIN PEPTIDASE (Bacteroidesovatus) |
PF09375(Peptidase_M75) | 5 | ASP A 258PHE A 83LEU A 172LEU A 249PHE A 311 | None | 1.16A | 3ko0A-3n8uA:undetectable3ko0B-3n8uA:undetectable3ko0I-3n8uA:undetectable3ko0J-3n8uA:undetectable | 3ko0A-3n8uA:14.113ko0B-3n8uA:14.113ko0I-3n8uA:14.113ko0J-3n8uA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqv | ALBC (Streptomycesnoursei) |
PF16715(CDPS) | 5 | ASP A 205LEU A 212SER A 213PHE A 211ILE A 208 | NoneNoneNoneNoneDTD A 248 ( 4.1A) | 1.24A | 3ko0A-3oqvA:undetectable3ko0B-3oqvA:undetectable3ko0I-3oqvA:undetectable3ko0J-3oqvA:undetectable | 3ko0A-3oqvA:15.733ko0B-3oqvA:15.733ko0I-3oqvA:15.733ko0J-3oqvA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p6b | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Ruminiclostridiumthermocellum) |
PF02018(CBM_4_9) | 5 | LEU A 99ASP A 162LEU A 190PHE A 167ILE A 123 | None | 1.28A | 3ko0A-3p6bA:undetectable3ko0B-3p6bA:undetectable3ko0I-3p6bA:undetectable3ko0J-3p6bA:undetectable | 3ko0A-3p6bA:20.713ko0B-3p6bA:20.713ko0I-3p6bA:20.713ko0J-3p6bA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ph2 | CYTOCHROME C6 (Phormidiumlaminosum) |
PF13442(Cytochrome_CBB3) | 5 | PHE B 11LEU B 79ASP B 80LEU B 37ILE B 48 | NoneNoneNoneNoneHEM B1087 ( 4.4A) | 1.22A | 3ko0A-3ph2B:undetectable3ko0B-3ph2B:undetectable3ko0I-3ph2B:undetectable3ko0J-3ph2B:undetectable | 3ko0A-3ph2B:19.003ko0B-3ph2B:19.003ko0I-3ph2B:19.003ko0J-3ph2B:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r11 | ENZYME OF ENOLASESUPERFAMILY (Francisellaphilomiragia) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 107ASP A 111SER A 310PHE A 311ILE A 276 | None | 1.09A | 3ko0A-3r11A:undetectable3ko0B-3r11A:undetectable3ko0I-3r11A:undetectable3ko0J-3r11A:undetectable | 3ko0A-3r11A:12.403ko0B-3r11A:12.403ko0I-3r11A:12.403ko0J-3r11A:12.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3skv | SSFX3 (Streptomycessp. SF2575) |
PF13472(Lipase_GDSL_2) | 5 | PHE A 253LEU A 223ASP A 222LEU A 203ILE A 169 | None | 1.16A | 3ko0A-3skvA:undetectable3ko0B-3skvA:undetectable3ko0I-3skvA:undetectable3ko0J-3skvA:undetectable | 3ko0A-3skvA:14.713ko0B-3skvA:14.713ko0I-3skvA:14.713ko0J-3skvA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqi | KLLA0E03807P (Kluyveromyceslactis) |
PF16787(NDC10_II) | 5 | ASP A 170LEU A 177LEU A 341SER A 343ILE A 199 | None | 1.18A | 3ko0A-3sqiA:undetectable3ko0B-3sqiA:undetectable3ko0I-3sqiA:0.03ko0J-3sqiA:undetectable | 3ko0A-3sqiA:12.243ko0B-3sqiA:12.243ko0I-3sqiA:12.243ko0J-3sqiA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t79 | KLLA0E03807P (Kluyveromyceslactis) |
PF16787(NDC10_II) | 5 | ASP A 170LEU A 177LEU A 341SER A 343ILE A 199 | None | 1.26A | 3ko0A-3t79A:undetectable3ko0B-3t79A:undetectable3ko0I-3t79A:undetectable3ko0J-3t79A:undetectable | 3ko0A-3t79A:13.683ko0B-3t79A:13.683ko0I-3t79A:13.683ko0J-3t79A:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbk | RIG-I HELICASEDOMAIN (Mus musculus) |
PF00271(Helicase_C)PF04851(ResIII) | 5 | PHE A 777LEU A 435ASP A 436LEU A 431ILE A 262 | EDO A 795 ( 3.6A)NoneNoneNoneNone | 0.83A | 3ko0A-3tbkA:undetectable3ko0B-3tbkA:undetectable3ko0I-3tbkA:undetectable3ko0J-3tbkA:undetectable | 3ko0A-3tbkA:10.993ko0B-3tbkA:10.993ko0I-3tbkA:10.993ko0J-3tbkA:10.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3udu | 3-ISOPROPYLMALATEDEHYDROGENASE (Campylobacterjejuni) |
PF00180(Iso_dh) | 5 | ASP A 132LEU A 260LEU A 324SER A 321ILE A 293 | None | 1.22A | 3ko0A-3uduA:0.63ko0B-3uduA:0.63ko0I-3uduA:0.73ko0J-3uduA:0.6 | 3ko0A-3uduA:16.223ko0B-3uduA:16.223ko0I-3uduA:16.223ko0J-3uduA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdj | TYPE I PULLULANASE (Anoxybacillussp. LM18-11) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | PHE A 283LEU A 277ASP A 342LEU A 325ILE A 229 | None | 1.26A | 3ko0A-3wdjA:undetectable3ko0B-3wdjA:undetectable3ko0I-3wdjA:undetectable3ko0J-3wdjA:undetectable | 3ko0A-3wdjA:9.153ko0B-3wdjA:9.153ko0I-3wdjA:9.153ko0J-3wdjA:9.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnp | CYCLOISOMALTOOLIGOSACCHARIDEGLUCANOTRANSFERASE (Bacilluscirculans) |
PF13199(Glyco_hydro_66)PF16990(CBM_35) | 5 | ASP A 325LEU A 334PHE A 333ILE A 236PHE A 264 | None | 1.10A | 3ko0A-3wnpA:undetectable3ko0B-3wnpA:undetectable3ko0I-3wnpA:undetectable3ko0J-3wnpA:undetectable | 3ko0A-3wnpA:9.043ko0B-3wnpA:9.043ko0I-3wnpA:9.043ko0J-3wnpA:9.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wvs | PUTATIVEMONOOXYGENASE (Streptomycessp. SN-593) |
PF00067(p450) | 5 | LEU A 336ASP A 337LEU A 281PHE A 284ILE A 334 | None | 1.26A | 3ko0A-3wvsA:undetectable3ko0B-3wvsA:undetectable3ko0I-3wvsA:undetectable3ko0J-3wvsA:undetectable | 3ko0A-3wvsA:12.563ko0B-3wvsA:12.563ko0I-3wvsA:12.563ko0J-3wvsA:12.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aie | GLUCAN1,6-ALPHA-GLUCOSIDASE (Lactobacillusacidophilus) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ASP A 316PHE A 352LEU A 49ASP A 97PHE A 18 | GOL A1548 (-3.5A)NoneNoneNoneNone | 1.26A | 3ko0A-4aieA:undetectable3ko0B-4aieA:undetectable3ko0I-4aieA:undetectable3ko0J-4aieA:undetectable | 3ko0A-4aieA:11.873ko0B-4aieA:11.873ko0I-4aieA:11.873ko0J-4aieA:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4anj | UNCONVENTIONALMYOSIN-VI, GREENFLUORESCENT PROTEIN (Aequoreavictoria;Sus scrofa) |
PF00063(Myosin_head)PF01353(GFP) | 5 | PHE A 751ASP A 748LEU A 738ILE A 769PHE A 705 | None | 1.22A | 3ko0A-4anjA:undetectable3ko0B-4anjA:undetectable3ko0I-4anjA:undetectable3ko0J-4anjA:undetectable | 3ko0A-4anjA:6.933ko0B-4anjA:6.933ko0I-4anjA:6.933ko0J-4anjA:6.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhd | SERINEHYDROXYMETHYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF00464(SHMT) | 5 | ASP A 351ASP A 318LEU A 332PHE A 327ILE A 325 | None | 1.14A | 3ko0A-4bhdA:undetectable3ko0B-4bhdA:undetectable3ko0I-4bhdA:undetectable3ko0J-4bhdA:undetectable | 3ko0A-4bhdA:12.383ko0B-4bhdA:12.383ko0I-4bhdA:12.383ko0J-4bhdA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h5i | GUANINENUCLEOTIDE-EXCHANGEFACTOR SEC12 (Saccharomycescerevisiae) |
no annotation | 5 | ASP A 70PHE A 117LEU A 84LEU A 164SER A 120 | None | 1.22A | 3ko0A-4h5iA:undetectable3ko0B-4h5iA:undetectable3ko0I-4h5iA:undetectable3ko0J-4h5iA:undetectable | 3ko0A-4h5iA:15.693ko0B-4h5iA:15.693ko0I-4h5iA:15.693ko0J-4h5iA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwt | THREONINE--TRNALIGASE, CYTOPLASMIC (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | ASP A 495LEU A 596ILE A 509CYH A 512PHE A 515 | 1B2 A 802 (-3.6A)NoneNoneNoneNone | 1.21A | 3ko0A-4hwtA:1.13ko0B-4hwtA:1.23ko0I-4hwtA:1.13ko0J-4hwtA:1.0 | 3ko0A-4hwtA:14.493ko0B-4hwtA:14.493ko0I-4hwtA:14.493ko0J-4hwtA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwm | UPF0135 PROTEINMJ0927 (Methanocaldococcusjannaschii) |
PF01784(NIF3) | 5 | LEU A 240ASP A 241LEU A 45PHE A 66ILE A 11 | None | 1.15A | 3ko0A-4iwmA:undetectable3ko0B-4iwmA:undetectable3ko0I-4iwmA:undetectable3ko0J-4iwmA:1.2 | 3ko0A-4iwmA:17.053ko0B-4iwmA:17.053ko0I-4iwmA:17.053ko0J-4iwmA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lnz | UNCONVENTIONALMYOSIN-VB (Homo sapiens) |
PF01843(DIL) | 5 | LEU A1480ASP A1476LEU A1524SER A1523ILE A1481 | None | 1.20A | 3ko0A-4lnzA:1.63ko0B-4lnzA:1.73ko0I-4lnzA:1.73ko0J-4lnzA:1.6 | 3ko0A-4lnzA:14.903ko0B-4lnzA:14.903ko0I-4lnzA:14.903ko0J-4lnzA:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p53 | CYCLASE (Streptomyceshygroscopicus) |
PF01761(DHQ_synthase) | 5 | PHE A 119LEU A 129LEU A 85PHE A 92ILE A 67 | None | 1.17A | 3ko0A-4p53A:undetectable3ko0B-4p53A:undetectable3ko0I-4p53A:undetectable3ko0J-4p53A:undetectable | 3ko0A-4p53A:12.623ko0B-4p53A:12.623ko0I-4p53A:12.623ko0J-4p53A:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5d | LEUCINE RICH REPEATPROTEIN (syntheticconstruct) |
PF12354(Internalin_N)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 5 | LEU A 377ASP A 405LEU A 390ILE A 382CYH A 409 | None | 0.96A | 3ko0A-4r5dA:undetectable3ko0B-4r5dA:undetectable3ko0I-4r5dA:undetectable3ko0J-4r5dA:undetectable | 3ko0A-4r5dA:10.933ko0B-4r5dA:10.933ko0I-4r5dA:10.933ko0J-4r5dA:10.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1a | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF13200(DUF4015) | 5 | PHE A 162LEU A 114ASP A 113LEU A 95ILE A 120 | None | 1.12A | 3ko0A-4s1aA:undetectable3ko0B-4s1aA:undetectable3ko0I-4s1aA:undetectable3ko0J-4s1aA:undetectable | 3ko0A-4s1aA:18.983ko0B-4s1aA:18.983ko0I-4s1aA:18.983ko0J-4s1aA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u3t | PENICILLIN-BINDINGPROTEIN 2 (Neisseriagonorrhoeae) |
PF00905(Transpeptidase) | 5 | ASP A 346SER A 363PHE A 420SER A 368ILE A 413 | None | 1.25A | 3ko0A-4u3tA:undetectable3ko0B-4u3tA:undetectable3ko0I-4u3tA:undetectable3ko0J-4u3tA:undetectable | 3ko0A-4u3tA:15.763ko0B-4u3tA:15.763ko0I-4u3tA:15.763ko0J-4u3tA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4up7 | LYSINE--TRNA LIGASE (Entamoebahistolytica) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | LEU A 400ASP A 401LEU A 409PHE A 408ILE A 396 | None | 1.13A | 3ko0A-4up7A:undetectable3ko0B-4up7A:0.93ko0I-4up7A:undetectable3ko0J-4up7A:undetectable | 3ko0A-4up7A:9.513ko0B-4up7A:9.513ko0I-4up7A:9.513ko0J-4up7A:9.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wj0 | CRISPR-ASSOCIATEDENDONUCLEASE CAS1 (Pyrococcushorikoshii) |
PF01867(Cas_Cas1) | 5 | PHE A 65LEU A 6ASP A 39LEU A 14ILE A 8 | None | 1.17A | 3ko0A-4wj0A:undetectable3ko0B-4wj0A:undetectable3ko0I-4wj0A:undetectable3ko0J-4wj0A:undetectable | 3ko0A-4wj0A:16.943ko0B-4wj0A:16.943ko0I-4wj0A:16.943ko0J-4wj0A:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wz9 | AGAP004809-PA (Anophelesgambiae) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | LEU A 856ASP A 854LEU A 819PHE A 818ILE A 845 | None | 1.26A | 3ko0A-4wz9A:undetectable3ko0B-4wz9A:undetectable3ko0I-4wz9A:undetectable3ko0J-4wz9A:undetectable | 3ko0A-4wz9A:9.133ko0B-4wz9A:9.133ko0I-4wz9A:9.133ko0J-4wz9A:9.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z37 | PUTATIVE MIXEDPOLYKETIDESYNTHASE/NON-RIBOSOMAL PEPTIDESYNTHETASE (Brevibacillusbrevis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A2830ASP A2854LEU A2842SER A2844PHE A2845 | None | 1.27A | 3ko0A-4z37A:undetectable3ko0B-4z37A:undetectable3ko0I-4z37A:undetectable3ko0J-4z37A:undetectable | 3ko0A-4z37A:9.613ko0B-4z37A:9.613ko0I-4z37A:9.613ko0J-4z37A:9.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z61 | PHYTOSULFOKINERECEPTOR 1 (Daucus carota) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | PHE A 627LEU A 588ASP A 587LEU A 577ILE A 573 | None | 1.10A | 3ko0A-4z61A:undetectable3ko0B-4z61A:undetectable3ko0I-4z61A:undetectable3ko0J-4z61A:undetectable | 3ko0A-4z61A:10.843ko0B-4z61A:10.843ko0I-4z61A:10.843ko0J-4z61A:10.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z64 | PHYTOSULFOKINERECEPTOR 1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | PHE A 159LEU A 107ASP A 130LEU A 92ILE A 112 | NoneNoneNAG A 701 (-3.7A)NoneNone | 1.27A | 3ko0A-4z64A:undetectable3ko0B-4z64A:undetectable3ko0I-4z64A:undetectable3ko0J-4z64A:undetectable | 3ko0A-4z64A:11.793ko0B-4z64A:11.793ko0I-4z64A:11.793ko0J-4z64A:11.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z64 | PHYTOSULFOKINERECEPTOR 1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | PHE A 617LEU A 578ASP A 577LEU A 567ILE A 563 | None | 1.13A | 3ko0A-4z64A:undetectable3ko0B-4z64A:undetectable3ko0I-4z64A:undetectable3ko0J-4z64A:undetectable | 3ko0A-4z64A:11.793ko0B-4z64A:11.793ko0I-4z64A:11.793ko0J-4z64A:11.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zuz | SIDC (Legionellapneumophila) |
no annotation | 5 | SER A 613LEU A 727ASP A 728LEU A 617ILE A 724 | None | 1.21A | 3ko0A-4zuzA:undetectable3ko0B-4zuzA:undetectable3ko0I-4zuzA:undetectable3ko0J-4zuzA:undetectable | 3ko0A-4zuzA:7.523ko0B-4zuzA:7.523ko0I-4zuzA:7.523ko0J-4zuzA:7.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a01 | O-GLYCOSYLTRANSFERASE (Drosophilamelanogaster) |
PF13374(TPR_10)PF13414(TPR_11)PF13844(Glyco_transf_41) | 5 | SER A 599LEU A 643ASP A 642LEU A 589SER A 590 | None | 1.28A | 3ko0A-5a01A:undetectable3ko0B-5a01A:undetectable3ko0I-5a01A:undetectable3ko0J-5a01A:undetectable | 3ko0A-5a01A:9.453ko0B-5a01A:9.453ko0I-5a01A:9.453ko0J-5a01A:9.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5adv | ENTEROCHELIN UPTAKEPERIPLASMIC BINDINGPROTEIN (Campylobacterjejuni) |
PF01497(Peripla_BP_2) | 5 | SER A 40LEU A 56ASP A 57LEU A 126PHE A 122 | DMS A1314 ( 3.7A)NoneNoneNoneNone | 1.19A | 3ko0A-5advA:undetectable3ko0B-5advA:undetectable3ko0I-5advA:undetectable3ko0J-5advA:undetectable | 3ko0A-5advA:15.553ko0B-5advA:15.553ko0I-5advA:15.553ko0J-5advA:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b8i | CALCINEURIN SUBUNITB, VARIANTSERINE/THREONINE-PROTEIN PHOSPHATASE (Coccidioidesimmitis) |
PF00149(Metallophos)PF13202(EF-hand_5)PF13499(EF-hand_7) | 5 | ASP B 16LEU A 387LEU B 168SER B 83PHE B 82 | EDO B 205 (-3.6A)NoneNoneNoneNone | 1.09A | 3ko0A-5b8iB:5.93ko0B-5b8iB:6.33ko0I-5b8iB:6.33ko0J-5b8iB:6.2 | 3ko0A-5b8iB:19.543ko0B-5b8iB:19.543ko0I-5b8iB:19.543ko0J-5b8iB:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esv | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE,ENVELOPEGLYCOPROTEIN GP160 (Haemophilusinfluenzae;Humanimmunodeficiencyvirus 1) |
PF00516(GP120)PF02542(YgbB) | 5 | ASP E 237LEU E 209LEU E 285PHE E 246ILE E 213 | None | 1.15A | 3ko0A-5esvE:undetectable3ko0B-5esvE:undetectable3ko0I-5esvE:undetectable3ko0J-5esvE:undetectable | 3ko0A-5esvE:20.393ko0B-5esvE:20.393ko0I-5esvE:20.393ko0J-5esvE:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exr | DNA POLYMERASE ALPHASUBUNIT B (Homo sapiens) |
PF04042(DNA_pol_E_B)PF08418(Pol_alpha_B_N) | 5 | ASP D 358LEU D 382LEU D 394ILE D 401CYH D 405 | None | 1.20A | 3ko0A-5exrD:undetectable3ko0B-5exrD:undetectable3ko0I-5exrD:undetectable3ko0J-5exrD:undetectable | 3ko0A-5exrD:13.783ko0B-5exrD:13.783ko0I-5exrD:13.783ko0J-5exrD:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hei | NFRA2 (Bacillusmegaterium) |
PF00881(Nitroreductase) | 5 | LEU A 148LEU A 60ILE A 78CYH A 80PHE A 155 | None | 1.28A | 3ko0A-5heiA:undetectable3ko0B-5heiA:undetectable3ko0I-5heiA:undetectable3ko0J-5heiA:undetectable | 3ko0A-5heiA:19.843ko0B-5heiA:19.843ko0I-5heiA:19.843ko0J-5heiA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxs | SODIUM,CALCIUMEXCHANGER (Methanocaldococcusjannaschii) |
PF01699(Na_Ca_ex) | 5 | ASP A 240SER A 51LEU A 271LEU A 230ILE A 105 | SR A 401 ( 4.7A) SR A 401 ( 4.2A)NoneNoneNone | 1.10A | 3ko0A-5hxsA:0.23ko0B-5hxsA:undetectable3ko0I-5hxsA:undetectable3ko0J-5hxsA:undetectable | 3ko0A-5hxsA:12.623ko0B-5hxsA:12.623ko0I-5hxsA:12.623ko0J-5hxsA:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyh | UNCHARACTERIZEDPROTEIN (Streptomycesvenezuelae) |
PF11583(AurF) | 5 | SER A 164LEU A 94SER A 95PHE A 69ILE A 74 | None | 1.13A | 3ko0A-5hyhA:undetectable3ko0B-5hyhA:undetectable3ko0I-5hyhA:undetectable3ko0J-5hyhA:undetectable | 3ko0A-5hyhA:14.193ko0B-5hyhA:14.193ko0I-5hyhA:14.193ko0J-5hyhA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1c | WD REPEAT-CONTAININGPROTEIN 48 (Homo sapiens) |
PF00400(WD40) | 5 | ASP B 138LEU B 164LEU B 143SER B 134ILE B 183 | None | 1.13A | 3ko0A-5k1cB:undetectable3ko0B-5k1cB:undetectable3ko0I-5k1cB:undetectable3ko0J-5k1cB:undetectable | 3ko0A-5k1cB:9.963ko0B-5k1cB:9.963ko0I-5k1cB:9.963ko0J-5k1cB:9.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ksh | PENICILLIN-BINDINGPROTEIN 2 (Neisseriagonorrhoeae) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | ASP A 346SER A 363PHE A 420SER A 368ILE A 413 | None | 1.27A | 3ko0A-5kshA:undetectable3ko0B-5kshA:undetectable3ko0I-5kshA:undetectable3ko0J-5kshA:undetectable | 3ko0A-5kshA:10.703ko0B-5kshA:10.703ko0I-5kshA:10.703ko0J-5kshA:10.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n72 | WIPA (Legionellapneumophila) |
no annotation | 5 | ASP A 189LEU A 42LEU A 199PHE A 198ILE A 48 | None | 1.28A | 3ko0A-5n72A:undetectable3ko0B-5n72A:undetectable3ko0I-5n72A:undetectable3ko0J-5n72A:undetectable | 3ko0A-5n72A:14.023ko0B-5n72A:14.023ko0I-5n72A:14.023ko0J-5n72A:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n72 | WIPA (Legionellapneumophila) |
no annotation | 5 | ASP A 189LEU A 199LEU A 42PHE A 41ILE A 175 | None | 1.24A | 3ko0A-5n72A:undetectable3ko0B-5n72A:undetectable3ko0I-5n72A:undetectable3ko0J-5n72A:undetectable | 3ko0A-5n72A:14.023ko0B-5n72A:14.023ko0I-5n72A:14.023ko0J-5n72A:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubv | ATPASE DOMAIN OFI-AAA PROTEASE (Thermothelomycesthermophila) |
no annotation | 5 | PHE A 75LEU A 107ASP A 108LEU A 129ILE A 104 | None | 1.12A | 3ko0A-5ubvA:undetectable3ko0B-5ubvA:undetectable3ko0I-5ubvA:undetectable3ko0J-5ubvA:undetectable | 3ko0A-5ubvA:21.053ko0B-5ubvA:21.053ko0I-5ubvA:21.053ko0J-5ubvA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | X-RAY REPAIRCROSS-COMPLEMENTINGPROTEIN 5 (Homo sapiens) |
PF02735(Ku)PF03730(Ku_C)PF03731(Ku_N) | 5 | ASP B 72LEU B 111ASP B 109SER B 145ILE B 150 | None | 1.08A | 3ko0A-5y3rB:undetectable3ko0B-5y3rB:undetectable3ko0I-5y3rB:undetectable3ko0J-5y3rB:undetectable | 3ko0A-5y3rB:11.393ko0B-5y3rB:11.393ko0I-5y3rB:11.393ko0J-5y3rB:11.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bbp | CYTOHESIN-3,ADP-RIBOSYLATION FACTOR 6 (Homo sapiens;Mus musculus) |
no annotation | 5 | ASP A 386SER A 333LEU A 310LEU A 329ILE A 308 | None | 1.22A | 3ko0A-6bbpA:undetectable3ko0B-6bbpA:undetectable3ko0I-6bbpA:undetectable3ko0J-6bbpA:undetectable | 3ko0A-6bbpA:20.563ko0B-6bbpA:20.563ko0I-6bbpA:20.563ko0J-6bbpA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bni | LYSINE--TRNA LIGASE (Cryptosporidiumparvum) |
no annotation | 5 | PHE A 70LEU A 76SER A 98PHE A 156ILE A 118 | None | 1.28A | 3ko0A-6bniA:undetectable3ko0B-6bniA:1.73ko0I-6bniA:undetectable3ko0J-6bniA:1.6 | 3ko0A-6bniA:18.523ko0B-6bniA:18.523ko0I-6bniA:18.523ko0J-6bniA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6evj | RNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Avirus) |
no annotation | 5 | ASP B 112LEU B 102PHE B 103ILE B 262PHE B 254 | None | 1.08A | 3ko0A-6evjB:undetectable3ko0B-6evjB:undetectable3ko0I-6evjB:undetectable3ko0J-6evjB:undetectable | 3ko0A-6evjB:17.923ko0B-6evjB:17.923ko0I-6evjB:17.923ko0J-6evjB:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ezn | DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEINGLYCOSYLTRANSFERASESUBUNIT WBP1 (Saccharomycescerevisiae) |
no annotation | 5 | LEU G 110LEU G 238SER G 235PHE G 237ILE G 232 | None | 1.27A | 3ko0A-6eznG:undetectable3ko0B-6eznG:undetectable3ko0I-6eznG:undetectable3ko0J-6eznG:undetectable | 3ko0A-6eznG:27.173ko0B-6eznG:27.173ko0I-6eznG:27.173ko0J-6eznG:27.17 |