SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_I_TFPI202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 ASP A  92
SER A  99
GLU A 137
LEU A 136
ASP A 180
 None
 1.24A 3ko0G-1dysA:
0.0
3ko0H-1dysA:
undetectable
3ko0I-1dysA:
0.0
3ko0J-1dysA:
0.0		 3ko0G-1dysA:
10.63
3ko0H-1dysA:
10.63
3ko0I-1dysA:
10.63
3ko0J-1dysA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 SYNTAXIN 8
VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1

(Mus musculus;
Rattus
norvegicus) 		PF12352
(V-SNARE_C)
no annotation 		5 LEU C 167
ILE D 172
GLU D 175
LEU D 176
ASP D 177
 None
 1.23A 3ko0G-1gl2C:
undetectable
3ko0H-1gl2C:
undetectable
3ko0I-1gl2C:
undetectable
3ko0J-1gl2C:
undetectable		 3ko0G-1gl2C:
20.79
3ko0H-1gl2C:
20.79
3ko0I-1gl2C:
20.79
3ko0J-1gl2C:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		5 ASP A 116
LEU A  82
PHE A  81
CYH A  99
LEU A 125
 None
None
None
NAD  A1382 (-4.5A)
None
 1.11A 3ko0G-1gy8A:
undetectable
3ko0H-1gy8A:
undetectable
3ko0I-1gy8A:
undetectable
3ko0J-1gy8A:
undetectable		 3ko0G-1gy8A:
13.92
3ko0H-1gy8A:
13.92
3ko0I-1gy8A:
13.92
3ko0J-1gy8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		5 PHE A  82
LEU A 303
ILE A  57
LEU A  37
ASP A  36
 None
 1.28A 3ko0G-1hleA:
0.0
3ko0H-1hleA:
undetectable
3ko0I-1hleA:
0.0
3ko0J-1hleA:
0.0		 3ko0G-1hleA:
13.98
3ko0H-1hleA:
13.98
3ko0I-1hleA:
13.98
3ko0J-1hleA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn1 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Haemophilus
influenzae) 		PF02542
(YgbB) 		5 ASP A  73
LEU A 121
PHE A  82
ILE A  49
LEU A  45
 None
 1.17A 3ko0G-1jn1A:
undetectable
3ko0H-1jn1A:
undetectable
3ko0I-1jn1A:
undetectable
3ko0J-1jn1A:
undetectable		 3ko0G-1jn1A:
20.67
3ko0H-1jn1A:
20.67
3ko0I-1jn1A:
20.67
3ko0J-1jn1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A  73
ILE A   9
GLU A  12
LEU A  13
ASP A  14
 None
 1.21A 3ko0G-1kyiA:
0.0
3ko0H-1kyiA:
undetectable
3ko0I-1kyiA:
0.0
3ko0J-1kyiA:
0.0		 3ko0G-1kyiA:
12.19
3ko0H-1kyiA:
12.19
3ko0I-1kyiA:
12.19
3ko0J-1kyiA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		5 SER A  16
PHE A  64
ILE A 280
CYH A 263
LEU A 259
 None
 1.23A 3ko0G-1luaA:
0.0
3ko0H-1luaA:
undetectable
3ko0I-1luaA:
0.0
3ko0J-1luaA:
0.0		 3ko0G-1luaA:
15.25
3ko0H-1luaA:
15.25
3ko0I-1luaA:
15.25
3ko0J-1luaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A 296
SER A 297
PHE A 301
ILE A 304
LEU A 325
 None
 1.16A 3ko0G-1pztA:
undetectable
3ko0H-1pztA:
undetectable
3ko0I-1pztA:
undetectable
3ko0J-1pztA:
undetectable		 3ko0G-1pztA:
17.80
3ko0H-1pztA:
17.80
3ko0I-1pztA:
17.80
3ko0J-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 ASP A  24
LEU A  32
PHE A  29
ILE A 108
LEU A  64
 None
 1.22A 3ko0G-1q3bA:
1.4
3ko0H-1q3bA:
1.4
3ko0I-1q3bA:
1.4
3ko0J-1q3bA:
1.4		 3ko0G-1q3bA:
17.05
3ko0H-1q3bA:
17.05
3ko0I-1q3bA:
17.05
3ko0J-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ASP A 139
LEU A 114
SER A 115
LEU A 393
ASP A 392
 None
 1.21A 3ko0G-1u3dA:
0.3
3ko0H-1u3dA:
undetectable
3ko0I-1u3dA:
0.4
3ko0J-1u3dA:
0.4		 3ko0G-1u3dA:
11.39
3ko0H-1u3dA:
11.39
3ko0I-1u3dA:
11.39
3ko0J-1u3dA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 LEU A 207
SER A 174
ILE A 225
LEU A 231
ASP A 230
 None
PLP  A 413 ( 3.9A)
None
None
None
 1.23A 3ko0G-1ve1A:
0.0
3ko0H-1ve1A:
undetectable
3ko0I-1ve1A:
0.0
3ko0J-1ve1A:
0.0		 3ko0G-1ve1A:
16.56
3ko0H-1ve1A:
16.56
3ko0I-1ve1A:
16.56
3ko0J-1ve1A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 ASP A 277
SER A 280
LEU A 243
LEU A 110
ASP A 111
 None
 0.98A 3ko0G-1vp4A:
0.0
3ko0H-1vp4A:
undetectable
3ko0I-1vp4A:
0.0
3ko0J-1vp4A:
0.0		 3ko0G-1vp4A:
13.44
3ko0H-1vp4A:
13.44
3ko0I-1vp4A:
13.44
3ko0J-1vp4A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 SER A 168
LEU A 175
ILE A  55
PHE A   7
LEU A  59
 None
 1.08A 3ko0G-2e0iA:
0.0
3ko0H-2e0iA:
undetectable
3ko0I-2e0iA:
0.0
3ko0J-2e0iA:
0.0		 3ko0G-2e0iA:
12.59
3ko0H-2e0iA:
12.59
3ko0I-2e0iA:
12.59
3ko0J-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 LEU A 156
SER A 157
ILE A 164
GLU A 160
LEU A 134
 None
 1.20A 3ko0G-2ghiA:
undetectable
3ko0H-2ghiA:
undetectable
3ko0I-2ghiA:
undetectable
3ko0J-2ghiA:
undetectable		 3ko0G-2ghiA:
17.14
3ko0H-2ghiA:
17.14
3ko0I-2ghiA:
17.14
3ko0J-2ghiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 910
PHE A 909
ILE A 888
CYH A 892
LEU A 845
 None
 0.92A 3ko0G-2ogvA:
undetectable
3ko0H-2ogvA:
undetectable
3ko0I-2ogvA:
undetectable
3ko0J-2ogvA:
undetectable		 3ko0G-2ogvA:
15.41
3ko0H-2ogvA:
15.41
3ko0I-2ogvA:
15.41
3ko0J-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20

(Homo sapiens) 		PF00270
(DEAD) 		5 PHE A  64
PHE A  82
ILE A 153
LEU A 121
ASP A 122
 None
ADP  A 300 (-4.4A)
None
None
None
 1.28A 3ko0G-2oxcA:
undetectable
3ko0H-2oxcA:
undetectable
3ko0I-2oxcA:
undetectable
3ko0J-2oxcA:
undetectable		 3ko0G-2oxcA:
19.37
3ko0H-2oxcA:
19.37
3ko0I-2oxcA:
19.37
3ko0J-2oxcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 ASP A 257
LEU A  82
SER A  84
PHE A  86
LEU A 117
 None
 1.21A 3ko0G-2q83A:
undetectable
3ko0H-2q83A:
undetectable
3ko0I-2q83A:
undetectable
3ko0J-2q83A:
undetectable		 3ko0G-2q83A:
15.38
3ko0H-2q83A:
15.38
3ko0I-2q83A:
15.38
3ko0J-2q83A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 PHE A 751
LEU A 738
ILE A 769
PHE A 705
ASP A 748
 None
 1.19A 3ko0G-2v26A:
undetectable
3ko0H-2v26A:
undetectable
3ko0I-2v26A:
undetectable
3ko0J-2v26A:
undetectable		 3ko0G-2v26A:
9.24
3ko0H-2v26A:
9.24
3ko0I-2v26A:
9.24
3ko0J-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02847
(MA3) 		5 ASP A 219
LEU B 390
SER B 393
GLU B 348
LEU B 351
 None
 1.25A 3ko0G-2zu6A:
undetectable
3ko0H-2zu6A:
undetectable
3ko0I-2zu6A:
undetectable
3ko0J-2zu6A:
undetectable		 3ko0G-2zu6A:
13.40
3ko0H-2zu6A:
13.40
3ko0I-2zu6A:
13.40
3ko0J-2zu6A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		5 PHE B  85
LEU B  68
SER B  70
PHE B  71
LEU B 106
 None
None
HEM  B 401 ( 3.8A)
None
HEM  B 401 ( 4.5A)
 1.14A 3ko0G-3a0gB:
undetectable
3ko0H-3a0gB:
undetectable
3ko0I-3a0gB:
undetectable
3ko0J-3a0gB:
undetectable		 3ko0G-3a0gB:
21.92
3ko0H-3a0gB:
21.92
3ko0I-3a0gB:
21.92
3ko0J-3a0gB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 SER A 479
LEU A 448
PHE A 444
ILE A 572
LEU A 577
 None
 1.25A 3ko0G-3ctzA:
undetectable
3ko0H-3ctzA:
undetectable
3ko0I-3ctzA:
undetectable
3ko0J-3ctzA:
undetectable		 3ko0G-3ctzA:
9.50
3ko0H-3ctzA:
9.50
3ko0I-3ctzA:
9.50
3ko0J-3ctzA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 PHE A  81
LEU A  25
PHE A  22
ILE A  49
LEU A  69
 None
 1.25A 3ko0G-3e1kA:
undetectable
3ko0H-3e1kA:
undetectable
3ko0I-3e1kA:
undetectable
3ko0J-3e1kA:
undetectable		 3ko0G-3e1kA:
13.62
3ko0H-3e1kA:
13.62
3ko0I-3e1kA:
13.62
3ko0J-3e1kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 ASP A 164
SER A 171
PHE A 410
ILE A 395
PHE A 298
 None
 1.22A 3ko0G-3eafA:
undetectable
3ko0H-3eafA:
undetectable
3ko0I-3eafA:
undetectable
3ko0J-3eafA:
undetectable		 3ko0G-3eafA:
12.92
3ko0H-3eafA:
12.92
3ko0I-3eafA:
12.92
3ko0J-3eafA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		5 SER A 106
PHE A 105
ILE A 113
GLU A 109
LEU A  68
 None
 1.27A 3ko0G-3f41A:
undetectable
3ko0H-3f41A:
undetectable
3ko0I-3f41A:
undetectable
3ko0J-3f41A:
undetectable		 3ko0G-3f41A:
10.39
3ko0H-3f41A:
10.39
3ko0I-3f41A:
10.39
3ko0J-3f41A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 LEU A 146
ILE A 122
CYH A 133
PHE A 132
LEU A 154
 None
 1.21A 3ko0G-3fkdA:
undetectable
3ko0H-3fkdA:
undetectable
3ko0I-3fkdA:
undetectable
3ko0J-3fkdA:
undetectable		 3ko0G-3fkdA:
12.82
3ko0H-3fkdA:
12.82
3ko0I-3fkdA:
12.82
3ko0J-3fkdA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8w LACTOCOCCAL PROPHAGE
PS3 PROTEIN 05

(Staphylococcus
epidermidis) 		PF13420
(Acetyltransf_4) 		5 LEU A 115
ILE A 103
CYH A  67
PHE A  87
LEU A  69
 None
 1.27A 3ko0G-3g8wA:
undetectable
3ko0H-3g8wA:
undetectable
3ko0I-3g8wA:
undetectable
3ko0J-3g8wA:
undetectable		 3ko0G-3g8wA:
25.00
3ko0H-3g8wA:
25.00
3ko0I-3g8wA:
25.00
3ko0J-3g8wA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 293
SER A 290
ILE A 257
CYH A 259
LEU A 312
 None
 1.24A 3ko0G-3h11A:
undetectable
3ko0H-3h11A:
undetectable
3ko0I-3h11A:
undetectable
3ko0J-3h11A:
undetectable		 3ko0G-3h11A:
15.79
3ko0H-3h11A:
15.79
3ko0I-3h11A:
15.79
3ko0J-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		5 SER A 191
LEU A 161
ILE A 166
CYH A 174
LEU A 203
 None
 1.22A 3ko0G-3h7kA:
undetectable
3ko0H-3h7kA:
undetectable
3ko0I-3h7kA:
undetectable
3ko0J-3h7kA:
undetectable		 3ko0G-3h7kA:
14.13
3ko0H-3h7kA:
14.13
3ko0I-3h7kA:
14.13
3ko0J-3h7kA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 PHE A 381
LEU A 416
ILE A 408
LEU A 437
ASP A 436
 None
None
None
None
NDG  A4701 ( 3.1A)
 1.18A 3ko0G-3i2tA:
undetectable
3ko0H-3i2tA:
undetectable
3ko0I-3i2tA:
undetectable
3ko0J-3i2tA:
undetectable		 3ko0G-3i2tA:
11.34
3ko0H-3i2tA:
11.34
3ko0I-3i2tA:
11.34
3ko0J-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 ASP A 101
SER A  25
LEU A  19
PHE A  48
LEU A 115
 None
 1.20A 3ko0G-3jr3A:
undetectable
3ko0H-3jr3A:
undetectable
3ko0I-3jr3A:
undetectable
3ko0J-3jr3A:
undetectable		 3ko0G-3jr3A:
20.18
3ko0H-3jr3A:
20.18
3ko0I-3jr3A:
20.18
3ko0J-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4

(Homo sapiens) 		no annotation 5 SER A 377
LEU A 230
SER A 331
ILE A 254
PHE A 251
 None
 1.15A 3ko0G-3l15A:
undetectable
3ko0H-3l15A:
undetectable
3ko0I-3l15A:
undetectable
3ko0J-3l15A:
undetectable		 3ko0G-3l15A:
20.36
3ko0H-3l15A:
20.36
3ko0I-3l15A:
20.36
3ko0J-3l15A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ASP A 227
LEU A 236
SER A 234
ILE A 269
LEU A 219
 None
 1.26A 3ko0G-3nizA:
undetectable
3ko0H-3nizA:
undetectable
3ko0I-3nizA:
undetectable
3ko0J-3nizA:
undetectable		 3ko0G-3nizA:
15.41
3ko0H-3nizA:
15.41
3ko0I-3nizA:
15.41
3ko0J-3nizA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		5 LEU A 212
SER A 213
PHE A 211
ILE A 208
ASP A 205
 None
None
None
DTD  A 248 ( 4.1A)
None
 1.25A 3ko0G-3oqvA:
undetectable
3ko0H-3oqvA:
undetectable
3ko0I-3oqvA:
undetectable
3ko0J-3oqvA:
undetectable		 3ko0G-3oqvA:
15.73
3ko0H-3oqvA:
15.73
3ko0I-3oqvA:
15.73
3ko0J-3oqvA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6b CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9) 		5 LEU A 190
PHE A 167
ILE A 123
LEU A  99
ASP A 162
 None
 1.28A 3ko0G-3p6bA:
undetectable
3ko0H-3p6bA:
undetectable
3ko0I-3p6bA:
undetectable
3ko0J-3p6bA:
undetectable		 3ko0G-3p6bA:
20.71
3ko0H-3p6bA:
20.71
3ko0I-3p6bA:
20.71
3ko0J-3p6bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph2 CYTOCHROME C6

(Phormidium
laminosum) 		PF13442
(Cytochrome_CBB3) 		5 PHE B  11
LEU B  37
ILE B  48
LEU B  79
ASP B  80
 None
None
HEM  B1087 ( 4.4A)
None
None
 1.19A 3ko0G-3ph2B:
undetectable
3ko0H-3ph2B:
undetectable
3ko0I-3ph2B:
undetectable
3ko0J-3ph2B:
undetectable		 3ko0G-3ph2B:
19.00
3ko0H-3ph2B:
19.00
3ko0I-3ph2B:
19.00
3ko0J-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qef BETA-XYLOSIDASE/ALPH
A-L-ARABINFURANOSIDA
SE, GLY43N

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		5 SER A 170
LEU A 256
SER A 229
ILE A 310
LEU A 302
 None
 1.13A 3ko0G-3qefA:
undetectable
3ko0H-3qefA:
undetectable
3ko0I-3qefA:
undetectable
3ko0J-3qefA:
undetectable		 3ko0G-3qefA:
17.26
3ko0H-3qefA:
17.26
3ko0I-3qefA:
17.26
3ko0J-3qefA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A 310
PHE A 311
ILE A 276
LEU A 107
ASP A 111
 None
 1.11A 3ko0G-3r11A:
undetectable
3ko0H-3r11A:
undetectable
3ko0I-3r11A:
undetectable
3ko0J-3r11A:
undetectable		 3ko0G-3r11A:
12.40
3ko0H-3r11A:
12.40
3ko0I-3r11A:
12.40
3ko0J-3r11A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		5 LEU A  81
PHE A  84
ILE A  92
PHE A 296
LEU A  26
 None
None
None
CAC  A 370 (-3.5A)
None
 1.26A 3ko0G-3rhgA:
undetectable
3ko0H-3rhgA:
undetectable
3ko0I-3rhgA:
undetectable
3ko0J-3rhgA:
undetectable		 3ko0G-3rhgA:
13.42
3ko0H-3rhgA:
13.42
3ko0I-3rhgA:
13.42
3ko0J-3rhgA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		5 PHE A 253
LEU A 203
ILE A 169
LEU A 223
ASP A 222
 None
 1.16A 3ko0G-3skvA:
undetectable
3ko0H-3skvA:
undetectable
3ko0I-3skvA:
undetectable
3ko0J-3skvA:
undetectable		 3ko0G-3skvA:
14.71
3ko0H-3skvA:
14.71
3ko0I-3skvA:
14.71
3ko0J-3skvA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 PHE A 777
LEU A 431
ILE A 262
LEU A 435
ASP A 436
 EDO  A 795 ( 3.6A)
None
None
None
None
 0.85A 3ko0G-3tbkA:
undetectable
3ko0H-3tbkA:
undetectable
3ko0I-3tbkA:
undetectable
3ko0J-3tbkA:
undetectable		 3ko0G-3tbkA:
10.99
3ko0H-3tbkA:
10.99
3ko0I-3tbkA:
10.99
3ko0J-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 ASP A 132
LEU A 324
SER A 321
ILE A 293
LEU A 260
 None
 1.25A 3ko0G-3uduA:
undetectable
3ko0H-3uduA:
0.6
3ko0I-3uduA:
0.6
3ko0J-3uduA:
0.6		 3ko0G-3uduA:
16.22
3ko0H-3uduA:
16.22
3ko0I-3uduA:
16.22
3ko0J-3uduA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		5 SER A  85
LEU A  62
ILE A  69
GLU A  92
LEU A  96
 None
 1.11A 3ko0G-3ue9A:
undetectable
3ko0H-3ue9A:
undetectable
3ko0I-3ue9A:
undetectable
3ko0J-3ue9A:
undetectable		 3ko0G-3ue9A:
13.17
3ko0H-3ue9A:
13.17
3ko0I-3ue9A:
13.17
3ko0J-3ue9A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Danio rerio;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PHE A 199
LEU A 137
ILE A 161
LEU A 178
ASP A 177
 None
 1.27A 3ko0G-3v44A:
undetectable
3ko0H-3v44A:
undetectable
3ko0I-3v44A:
undetectable
3ko0J-3v44A:
undetectable		 3ko0G-3v44A:
13.19
3ko0H-3v44A:
13.19
3ko0I-3v44A:
13.19
3ko0J-3v44A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 PHE A1537
LEU A1602
ILE A1656
LEU A1543
ASP A1544
 None
 1.19A 3ko0G-3vkgA:
undetectable
3ko0H-3vkgA:
undetectable
3ko0I-3vkgA:
undetectable
3ko0J-3vkgA:
undetectable		 3ko0G-3vkgA:
2.97
3ko0H-3vkgA:
2.97
3ko0I-3vkgA:
2.97
3ko0J-3vkgA:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 ASP A 325
LEU A 334
PHE A 333
ILE A 236
PHE A 264
 None
 1.17A 3ko0G-3wnpA:
undetectable
3ko0H-3wnpA:
undetectable
3ko0I-3wnpA:
undetectable
3ko0J-3wnpA:
undetectable		 3ko0G-3wnpA:
9.04
3ko0H-3wnpA:
9.04
3ko0I-3wnpA:
9.04
3ko0J-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		5 LEU A 281
PHE A 284
ILE A 334
LEU A 336
ASP A 337
 None
 1.26A 3ko0G-3wvsA:
undetectable
3ko0H-3wvsA:
undetectable
3ko0I-3wvsA:
undetectable
3ko0J-3wvsA:
undetectable		 3ko0G-3wvsA:
12.56
3ko0H-3wvsA:
12.56
3ko0I-3wvsA:
12.56
3ko0J-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zri CLPB PROTEIN

(Vibrio cholerae) 		PF02861
(Clp_N) 		5 LEU A 128
SER A 129
GLU A  39
LEU A  42
ASP A  43
 None
 1.24A 3ko0G-3zriA:
undetectable
3ko0H-3zriA:
undetectable
3ko0I-3zriA:
undetectable
3ko0J-3zriA:
undetectable		 3ko0G-3zriA:
21.59
3ko0H-3zriA:
21.59
3ko0I-3zriA:
21.59
3ko0J-3zriA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ASP A 316
PHE A 352
PHE A  18
LEU A  49
ASP A  97
 GOL  A1548 (-3.5A)
None
None
None
None
 1.21A 3ko0G-4aieA:
undetectable
3ko0H-4aieA:
undetectable
3ko0I-4aieA:
undetectable
3ko0J-4aieA:
undetectable		 3ko0G-4aieA:
11.87
3ko0H-4aieA:
11.87
3ko0I-4aieA:
11.87
3ko0J-4aieA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 PHE A 751
LEU A 738
ILE A 769
PHE A 705
ASP A 748
 None
 1.27A 3ko0G-4anjA:
undetectable
3ko0H-4anjA:
undetectable
3ko0I-4anjA:
undetectable
3ko0J-4anjA:
undetectable		 3ko0G-4anjA:
6.93
3ko0H-4anjA:
6.93
3ko0I-4anjA:
6.93
3ko0J-4anjA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 ASP A  58
LEU A  29
SER A  30
ILE A  25
LEU A  51
 None
 1.27A 3ko0G-4awnA:
undetectable
3ko0H-4awnA:
undetectable
3ko0I-4awnA:
undetectable
3ko0J-4awnA:
undetectable		 3ko0G-4awnA:
16.33
3ko0H-4awnA:
16.33
3ko0I-4awnA:
16.33
3ko0J-4awnA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 ASP A 351
LEU A 332
PHE A 327
ILE A 325
ASP A 318
 None
 1.23A 3ko0G-4bhdA:
undetectable
3ko0H-4bhdA:
undetectable
3ko0I-4bhdA:
undetectable
3ko0J-4bhdA:
undetectable		 3ko0G-4bhdA:
12.38
3ko0H-4bhdA:
12.38
3ko0I-4bhdA:
12.38
3ko0J-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 ASP A 570
SER A 596
LEU A 561
ILE A 550
LEU A 535
 None
 1.27A 3ko0G-4ecnA:
undetectable
3ko0H-4ecnA:
undetectable
3ko0I-4ecnA:
undetectable
3ko0J-4ecnA:
undetectable		 3ko0G-4ecnA:
9.28
3ko0H-4ecnA:
9.28
3ko0I-4ecnA:
9.28
3ko0J-4ecnA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3p GLUTAMINE-BINDING
PERIPLASMIC PROTEIN

(Burkholderia
pseudomallei) 		PF00497
(SBP_bac_3) 		5 PHE A 212
LEU A 226
SER A 105
ILE A  58
LEU A  54
 None
 1.14A 3ko0G-4f3pA:
undetectable
3ko0H-4f3pA:
undetectable
3ko0I-4f3pA:
undetectable
3ko0J-4f3pA:
undetectable		 3ko0G-4f3pA:
18.83
3ko0H-4f3pA:
18.83
3ko0I-4f3pA:
18.83
3ko0J-4f3pA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 228
SER A 231
ILE A 288
PHE A 252
GLU A 214
 None
 1.20A 3ko0G-4fidA:
undetectable
3ko0H-4fidA:
undetectable
3ko0I-4fidA:
undetectable
3ko0J-4fidA:
undetectable		 3ko0G-4fidA:
15.16
3ko0H-4fidA:
15.16
3ko0I-4fidA:
15.16
3ko0J-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 PHE A 208
LEU A 228
SER A 231
PHE A 252
GLU A 214
 None
 1.06A 3ko0G-4fidA:
undetectable
3ko0H-4fidA:
undetectable
3ko0I-4fidA:
undetectable
3ko0J-4fidA:
undetectable		 3ko0G-4fidA:
15.16
3ko0H-4fidA:
15.16
3ko0I-4fidA:
15.16
3ko0J-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF01746
(tRNA_m1G_MT) 		5 SER A  99
ILE A 255
GLU A 199
LEU A 197
ASP A 198
 None
 1.25A 3ko0G-4fmwA:
undetectable
3ko0H-4fmwA:
undetectable
3ko0I-4fmwA:
undetectable
3ko0J-4fmwA:
undetectable		 3ko0G-4fmwA:
22.22
3ko0H-4fmwA:
22.22
3ko0I-4fmwA:
22.22
3ko0J-4fmwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.27A 3ko0G-4hwtA:
0.8
3ko0H-4hwtA:
1.0
3ko0I-4hwtA:
1.1
3ko0J-4hwtA:
1.1		 3ko0G-4hwtA:
14.49
3ko0H-4hwtA:
14.49
3ko0I-4hwtA:
14.49
3ko0J-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 SER A 346
PHE A 343
ILE A 318
CYH A 362
PHE A 360
 None
 1.28A 3ko0G-4i5jA:
2.8
3ko0H-4i5jA:
3.0
3ko0I-4i5jA:
2.9
3ko0J-4i5jA:
2.9		 3ko0G-4i5jA:
17.96
3ko0H-4i5jA:
17.96
3ko0I-4i5jA:
17.96
3ko0J-4i5jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 LEU A 364
ILE A 368
GLU A 350
LEU A 347
ASP A 346
 None
 1.04A 3ko0G-4iggA:
1.4
3ko0H-4iggA:
1.4
3ko0I-4iggA:
1.4
3ko0J-4iggA:
1.4		 3ko0G-4iggA:
9.16
3ko0H-4iggA:
9.16
3ko0I-4iggA:
9.16
3ko0J-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		5 LEU A  45
PHE A  66
ILE A  11
LEU A 240
ASP A 241
 None
 1.14A 3ko0G-4iwmA:
undetectable
3ko0H-4iwmA:
undetectable
3ko0I-4iwmA:
undetectable
3ko0J-4iwmA:
1.2		 3ko0G-4iwmA:
17.05
3ko0H-4iwmA:
17.05
3ko0I-4iwmA:
17.05
3ko0J-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		5 SER A 353
LEU A 235
ILE A  98
LEU A 108
ASP A 109
 None
 0.91A 3ko0G-4j1lA:
undetectable
3ko0H-4j1lA:
undetectable
3ko0I-4j1lA:
undetectable
3ko0J-4j1lA:
undetectable		 3ko0G-4j1lA:
14.29
3ko0H-4j1lA:
14.29
3ko0I-4j1lA:
14.29
3ko0J-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 357
LEU A 289
PHE A 331
ILE A 295
ASP A  97
 None
 1.18A 3ko0G-4kwsA:
undetectable
3ko0H-4kwsA:
undetectable
3ko0I-4kwsA:
undetectable
3ko0J-4kwsA:
undetectable		 3ko0G-4kwsA:
13.82
3ko0H-4kwsA:
13.82
3ko0I-4kwsA:
13.82
3ko0J-4kwsA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 SER A 383
PHE A 380
ILE A 355
CYH A 399
PHE A 397
 None
 1.23A 3ko0G-4mewA:
5.2
3ko0H-4mewA:
3.0
3ko0I-4mewA:
4.3
3ko0J-4mewA:
2.8		 3ko0G-4mewA:
12.64
3ko0H-4mewA:
12.64
3ko0I-4mewA:
12.64
3ko0J-4mewA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 PHE A 119
LEU A  85
PHE A  92
ILE A  67
LEU A 129
 None
 1.14A 3ko0G-4p53A:
undetectable
3ko0H-4p53A:
undetectable
3ko0I-4p53A:
undetectable
3ko0J-4p53A:
undetectable		 3ko0G-4p53A:
12.62
3ko0H-4p53A:
12.62
3ko0I-4p53A:
12.62
3ko0J-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 LEU A  51
SER A  54
ILE A  78
PHE A1722
LEU A  74
 None
 1.25A 3ko0G-4r04A:
undetectable
3ko0H-4r04A:
undetectable
3ko0I-4r04A:
undetectable
3ko0J-4r04A:
undetectable		 3ko0G-4r04A:
4.44
3ko0H-4r04A:
4.44
3ko0I-4r04A:
4.44
3ko0J-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 390
ILE A 382
CYH A 409
LEU A 377
ASP A 405
 None
 1.00A 3ko0G-4r5dA:
undetectable
3ko0H-4r5dA:
undetectable
3ko0I-4r5dA:
undetectable
3ko0J-4r5dA:
undetectable		 3ko0G-4r5dA:
10.93
3ko0H-4r5dA:
10.93
3ko0I-4r5dA:
10.93
3ko0J-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r94 NON-STRUCTURAL
PROTEIN NS1

(Rodent
protoparvovirus
1) 		PF12433
(PV_NSP1) 		5 LEU A  37
ILE A  42
CYH A 161
GLU A 169
LEU A 173
 None
 1.23A 3ko0G-4r94A:
0.5
3ko0H-4r94A:
0.6
3ko0I-4r94A:
0.7
3ko0J-4r94A:
0.7		 3ko0G-4r94A:
16.86
3ko0H-4r94A:
16.86
3ko0I-4r94A:
16.86
3ko0J-4r94A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		5 PHE A 162
LEU A  95
ILE A 120
LEU A 114
ASP A 113
 None
 1.16A 3ko0G-4s1aA:
undetectable
3ko0H-4s1aA:
undetectable
3ko0I-4s1aA:
undetectable
3ko0J-4s1aA:
undetectable		 3ko0G-4s1aA:
18.98
3ko0H-4s1aA:
18.98
3ko0I-4s1aA:
18.98
3ko0J-4s1aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 ASP A 346
SER A 363
PHE A 420
SER A 368
ILE A 413
 None
 1.17A 3ko0G-4u3tA:
undetectable
3ko0H-4u3tA:
undetectable
3ko0I-4u3tA:
undetectable
3ko0J-4u3tA:
undetectable		 3ko0G-4u3tA:
15.76
3ko0H-4u3tA:
15.76
3ko0I-4u3tA:
15.76
3ko0J-4u3tA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8t ZYRO0G01672P

(Zygosaccharomyces
rouxii) 		PF04146
(YTH) 		5 ASP A 297
SER A 202
CYH A 236
PHE A 235
LEU A 188
 C  O   1 ( 4.8A)
None
None
None
None
 1.20A 3ko0G-4u8tA:
undetectable
3ko0H-4u8tA:
undetectable
3ko0I-4u8tA:
undetectable
3ko0J-4u8tA:
undetectable		 3ko0G-4u8tA:
19.21
3ko0H-4u8tA:
19.21
3ko0I-4u8tA:
19.21
3ko0J-4u8tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 409
PHE A 408
ILE A 396
LEU A 400
ASP A 401
 None
 1.06A 3ko0G-4up7A:
undetectable
3ko0H-4up7A:
undetectable
3ko0I-4up7A:
undetectable
3ko0J-4up7A:
undetectable		 3ko0G-4up7A:
9.51
3ko0H-4up7A:
9.51
3ko0I-4up7A:
9.51
3ko0J-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 LEU C 359
ILE C 590
CYH C 396
GLU C 592
LEU C 593
 None
 1.23A 3ko0G-4xgcC:
2.7
3ko0H-4xgcC:
2.7
3ko0I-4xgcC:
2.7
3ko0J-4xgcC:
2.5		 3ko0G-4xgcC:
8.97
3ko0H-4xgcC:
8.97
3ko0I-4xgcC:
8.97
3ko0J-4xgcC:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 PHE A 627
LEU A 577
ILE A 573
LEU A 588
ASP A 587
 None
 1.03A 3ko0G-4z61A:
undetectable
3ko0H-4z61A:
undetectable
3ko0I-4z61A:
undetectable
3ko0J-4z61A:
undetectable		 3ko0G-4z61A:
10.84
3ko0H-4z61A:
10.84
3ko0I-4z61A:
10.84
3ko0J-4z61A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE A 617
LEU A 567
ILE A 563
LEU A 578
ASP A 577
 None
 1.08A 3ko0G-4z64A:
undetectable
3ko0H-4z64A:
undetectable
3ko0I-4z64A:
undetectable
3ko0J-4z64A:
undetectable		 3ko0G-4z64A:
11.79
3ko0H-4z64A:
11.79
3ko0I-4z64A:
11.79
3ko0J-4z64A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		5 SER A  40
LEU A 126
PHE A 122
LEU A  56
ASP A  57
 DMS  A1314 ( 3.7A)
None
None
None
None
 1.26A 3ko0G-5advA:
undetectable
3ko0H-5advA:
undetectable
3ko0I-5advA:
undetectable
3ko0J-5advA:
undetectable		 3ko0G-5advA:
15.55
3ko0H-5advA:
15.55
3ko0I-5advA:
15.55
3ko0J-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 ASP A 593
LEU A 735
ILE A  21
PHE A 115
GLU A 724
 None
 1.26A 3ko0G-5ah5A:
undetectable
3ko0H-5ah5A:
undetectable
3ko0I-5ah5A:
undetectable
3ko0J-5ah5A:
undetectable		 3ko0G-5ah5A:
7.86
3ko0H-5ah5A:
7.86
3ko0I-5ah5A:
7.86
3ko0J-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 ASP A 417
SER A 403
LEU A  26
ILE A  61
GLU A  23
 None
 1.23A 3ko0G-5cykA:
undetectable
3ko0H-5cykA:
undetectable
3ko0I-5cykA:
undetectable
3ko0J-5cykA:
undetectable		 3ko0G-5cykA:
10.91
3ko0H-5cykA:
10.91
3ko0I-5cykA:
10.91
3ko0J-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF05891
(Methyltransf_PK) 		5 SER A  38
LEU A  49
SER A  45
PHE A  48
ASP A  67
 None
 1.11A 3ko0G-5e1bA:
undetectable
3ko0H-5e1bA:
undetectable
3ko0I-5e1bA:
undetectable
3ko0J-5e1bA:
undetectable		 3ko0G-5e1bA:
20.08
3ko0H-5e1bA:
20.08
3ko0I-5e1bA:
20.08
3ko0J-5e1bA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		5 ASP E 237
LEU E 285
PHE E 246
ILE E 213
LEU E 209
 None
 1.15A 3ko0G-5esvE:
undetectable
3ko0H-5esvE:
undetectable
3ko0I-5esvE:
undetectable
3ko0J-5esvE:
undetectable		 3ko0G-5esvE:
20.39
3ko0H-5esvE:
20.39
3ko0I-5esvE:
20.39
3ko0J-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		5 ASP A 214
LEU A 112
PHE A 109
ILE A 127
LEU A 167
 None
 1.28A 3ko0G-5frsA:
undetectable
3ko0H-5frsA:
undetectable
3ko0I-5frsA:
undetectable
3ko0J-5frsA:
undetectable		 3ko0G-5frsA:
8.68
3ko0H-5frsA:
8.68
3ko0I-5frsA:
8.68
3ko0J-5frsA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 LEU A  60
ILE A  78
CYH A  80
PHE A 155
LEU A 148
 None
 1.28A 3ko0G-5heiA:
undetectable
3ko0H-5heiA:
undetectable
3ko0I-5heiA:
undetectable
3ko0J-5heiA:
undetectable		 3ko0G-5heiA:
19.84
3ko0H-5heiA:
19.84
3ko0I-5heiA:
19.84
3ko0J-5heiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 ASP A 240
SER A  51
LEU A 230
ILE A 105
LEU A 271
 SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
None
None
None
 1.06A 3ko0G-5hxsA:
0.4
3ko0H-5hxsA:
undetectable
3ko0I-5hxsA:
undetectable
3ko0J-5hxsA:
undetectable		 3ko0G-5hxsA:
12.62
3ko0H-5hxsA:
12.62
3ko0I-5hxsA:
12.62
3ko0J-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 484
SER A 483
PHE A 487
GLU A 350
ASP A 351
 None
 1.15A 3ko0G-5iudA:
undetectable
3ko0H-5iudA:
undetectable
3ko0I-5iudA:
undetectable
3ko0J-5iudA:
undetectable		 3ko0G-5iudA:
7.87
3ko0H-5iudA:
7.87
3ko0I-5iudA:
7.87
3ko0J-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ASP A 346
SER A 363
PHE A 420
SER A 368
ILE A 413
 None
 1.19A 3ko0G-5kshA:
undetectable
3ko0H-5kshA:
undetectable
3ko0I-5kshA:
undetectable
3ko0J-5kshA:
undetectable		 3ko0G-5kshA:
10.70
3ko0H-5kshA:
10.70
3ko0I-5kshA:
10.70
3ko0J-5kshA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 5 SER A 290
LEU A 428
PHE A 427
LEU A 320
ASP A 319
 None
 1.11A 3ko0G-5m3xA:
undetectable
3ko0H-5m3xA:
0.4
3ko0I-5m3xA:
0.5
3ko0J-5m3xA:
undetectable		 3ko0G-5m3xA:
21.74
3ko0H-5m3xA:
21.74
3ko0I-5m3xA:
21.74
3ko0J-5m3xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		5 SER A 245
LEU A 265
ILE A 260
LEU A 134
ASP A 135
 None
 1.26A 3ko0G-5m8tA:
undetectable
3ko0H-5m8tA:
undetectable
3ko0I-5m8tA:
undetectable
3ko0J-5m8tA:
undetectable		 3ko0G-5m8tA:
16.01
3ko0H-5m8tA:
16.01
3ko0I-5m8tA:
16.01
3ko0J-5m8tA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxv SENSORY TRANSDUCTION
REGULATORY PROTEIN

(Bartonella
quintana) 		no annotation 5 ASP A  65
SER A  89
LEU A 127
PHE A  99
ILE A 102
 None
 1.00A 3ko0G-5uxvA:
undetectable
3ko0H-5uxvA:
undetectable
3ko0I-5uxvA:
undetectable
3ko0J-5uxvA:
undetectable		 3ko0G-5uxvA:
17.59
3ko0H-5uxvA:
17.59
3ko0I-5uxvA:
17.59
3ko0J-5uxvA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v07 EXONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 SER Z 222
PHE Z 215
LEU Z   7
ILE Z 195
ASP Z 171
 None
None
None
None
MN  Z 401 (-2.7A)
 1.26A 3ko0G-5v07Z:
undetectable
3ko0H-5v07Z:
undetectable
3ko0I-5v07Z:
undetectable
3ko0J-5v07Z:
undetectable		 3ko0G-5v07Z:
14.45
3ko0H-5v07Z:
14.45
3ko0I-5v07Z:
14.45
3ko0J-5v07Z:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		5 LEU A 513
SER A 512
PHE A 626
GLU A 617
ASP A 618
 None
 1.19A 3ko0G-5xblA:
undetectable
3ko0H-5xblA:
undetectable
3ko0I-5xblA:
undetectable
3ko0J-5xblA:
undetectable		 3ko0G-5xblA:
5.97
3ko0H-5xblA:
5.97
3ko0I-5xblA:
5.97
3ko0J-5xblA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 ASP B  72
SER B 145
ILE B 150
LEU B 111
ASP B 109
 None
 1.07A 3ko0G-5y3rB:
undetectable
3ko0H-5y3rB:
undetectable
3ko0I-5y3rB:
undetectable
3ko0J-5y3rB:
undetectable		 3ko0G-5y3rB:
11.39
3ko0H-5y3rB:
11.39
3ko0I-5y3rB:
11.39
3ko0J-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 5 SER A 231
SER A 237
PHE A 240
ILE A 122
LEU A 253
 SAM  A 505 (-4.4A)
None
None
None
None
 1.14A 3ko0G-5yf0A:
undetectable
3ko0H-5yf0A:
undetectable
3ko0I-5yf0A:
undetectable
3ko0J-5yf0A:
undetectable		 3ko0G-5yf0A:
undetectable
3ko0H-5yf0A:
undetectable
3ko0I-5yf0A:
undetectable
3ko0J-5yf0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 5 ASP A 209
LEU A 468
SER A 498
ILE A 487
LEU A 483
 None
 1.13A 3ko0G-5zxdA:
undetectable
3ko0H-5zxdA:
undetectable
3ko0I-5zxdA:
undetectable
3ko0J-5zxdA:
undetectable		 3ko0G-5zxdA:
undetectable
3ko0H-5zxdA:
undetectable
3ko0I-5zxdA:
undetectable
3ko0J-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 ASP A 386
SER A 333
LEU A 329
ILE A 308
LEU A 310
 None
 1.19A 3ko0G-6bbpA:
undetectable
3ko0H-6bbpA:
undetectable
3ko0I-6bbpA:
undetectable
3ko0J-6bbpA:
undetectable		 3ko0G-6bbpA:
20.56
3ko0H-6bbpA:
20.56
3ko0I-6bbpA:
20.56
3ko0J-6bbpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Danio rerio;
Eptatretus
burgeri) 		no annotation 5 PHE A 199
LEU A 137
ILE A 161
LEU A 178
ASP A 177
 None
 1.28A 3ko0G-6bxaA:
undetectable
3ko0H-6bxaA:
undetectable
3ko0I-6bxaA:
undetectable
3ko0J-6bxaA:
undetectable		 3ko0G-6bxaA:
19.39
3ko0H-6bxaA:
19.39
3ko0I-6bxaA:
19.39
3ko0J-6bxaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 5 ASP A 356
LEU A 271
SER A 270
ILE A 277
LEU A 337
 None
 1.19A 3ko0G-6cc2A:
undetectable
3ko0H-6cc2A:
undetectable
3ko0I-6cc2A:
undetectable
3ko0J-6cc2A:
undetectable		 3ko0G-6cc2A:
16.67
3ko0H-6cc2A:
16.67
3ko0I-6cc2A:
16.67
3ko0J-6cc2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens) 		no annotation 5 ASP A  48
SER A  46
LEU E 167
PHE E 113
ILE E 147
 None
 1.16A 3ko0G-6d6uA:
1.8
3ko0H-6d6uA:
undetectable
3ko0I-6d6uA:
undetectable
3ko0J-6d6uA:
undetectable		 3ko0G-6d6uA:
19.80
3ko0H-6d6uA:
19.80
3ko0I-6d6uA:
19.80
3ko0J-6d6uA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1

() 		no annotation 5 ASP E  48
SER E  46
LEU D 167
PHE D 113
ILE D 147
 None
 1.26A 3ko0G-6dw1E:
undetectable
3ko0H-6dw1E:
undetectable
3ko0I-6dw1E:
undetectable
3ko0J-6dw1E:
undetectable		 3ko0G-6dw1E:
undetectable
3ko0H-6dw1E:
undetectable
3ko0I-6dw1E:
undetectable
3ko0J-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
 None
 1.02A 3ko0G-6evjB:
undetectable
3ko0H-6evjB:
undetectable
3ko0I-6evjB:
undetectable
3ko0J-6evjB:
undetectable		 3ko0G-6evjB:
17.92
3ko0H-6evjB:
17.92
3ko0I-6evjB:
17.92
3ko0J-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 5 ASP A 874
LEU A 802
GLU A 775
LEU A 772
ASP A 771
 None
 1.23A 3ko0G-6fekA:
undetectable
3ko0H-6fekA:
undetectable
3ko0I-6fekA:
undetectable
3ko0J-6fekA:
undetectable		 3ko0G-6fekA:
23.53
3ko0H-6fekA:
23.53
3ko0I-6fekA:
23.53
3ko0J-6fekA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g42 MINOR CAPSID PROTEIN

(Cafeteriavirus-dependent
mavirus) 		no annotation 5 SER A  13
LEU A 295
PHE A  52
ILE A 202
LEU A 271
 None
 1.22A 3ko0G-6g42A:
undetectable
3ko0H-6g42A:
undetectable
3ko0I-6g42A:
undetectable
3ko0J-6g42A:
undetectable		 3ko0G-6g42A:
20.75
3ko0H-6g42A:
20.75
3ko0I-6g42A:
20.75
3ko0J-6g42A:
20.75