SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_H_TFPH202_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ag9 | FLAVODOXIN (Escherichiacoli) |
PF00258(Flavodoxin_1) | 5 | ASP A 145LEU A 142PHE A 86ILE A 18SER A 130 | None | 1.19A | 3ko0G-1ag9A:undetectable3ko0H-1ag9A:undetectable3ko0I-1ag9A:undetectable3ko0J-1ag9A:undetectable | 3ko0G-1ag9A:22.703ko0H-1ag9A:22.703ko0I-1ag9A:22.703ko0J-1ag9A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czk | FLAVODOXIN (Synechococcuselongatus) |
PF00258(Flavodoxin_1) | 5 | ASP A 144LEU A 141PHE A 86ILE A 17SER A 130 | None | 1.16A | 3ko0G-1czkA:undetectable3ko0H-1czkA:undetectable3ko0I-1czkA:undetectable3ko0J-1czkA:undetectable | 3ko0G-1czkA:21.023ko0H-1czkA:21.023ko0I-1czkA:21.023ko0J-1czkA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ij5 | PLASMODIAL SPECIFICLAV1-2 PROTEIN (Physarumpolycephalum) |
PF13202(EF-hand_5) | 5 | GLU A 343LEU A 339SER A 340PHE A 344ASP A 252 | None | 1.08A | 3ko0G-1ij5A:6.83ko0H-1ij5A:7.23ko0I-1ij5A:6.83ko0J-1ij5A:6.9 | 3ko0G-1ij5A:17.123ko0H-1ij5A:17.123ko0I-1ij5A:17.123ko0J-1ij5A:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1imv | PIGMENTEPITHELIUM-DERIVEDFACTOR (Homo sapiens) |
PF00079(Serpin) | 5 | ASP A 319LEU A 314ILE A 83PHE A 323SER A 184 | None | 1.31A | 3ko0G-1imvA:undetectable3ko0H-1imvA:undetectable3ko0I-1imvA:undetectable3ko0J-1imvA:undetectable | 3ko0G-1imvA:13.283ko0H-1imvA:13.283ko0I-1imvA:13.283ko0J-1imvA:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2v | PROTEIN TRANSPORTPROTEIN SEC24 (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | ASP B 731LEU B 499SER B 446PHE B 500SER B 315 | None | 1.47A | 3ko0G-1m2vB:0.03ko0H-1m2vB:undetectable3ko0I-1m2vB:1.33ko0J-1m2vB:0.0 | 3ko0G-1m2vB:7.343ko0H-1m2vB:7.343ko0I-1m2vB:7.343ko0J-1m2vB:7.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pz3 | ALPHA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF06964(Alpha-L-AF_C) | 5 | ASP A 439LEU A 436SER A 486ILE A 423ASP A 482 | None | 1.10A | 3ko0G-1pz3A:undetectable3ko0H-1pz3A:undetectable3ko0I-1pz3A:undetectable3ko0J-1pz3A:undetectable | 3ko0G-1pz3A:12.173ko0H-1pz3A:12.173ko0I-1pz3A:12.173ko0J-1pz3A:12.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tow | FATTY ACID-BINDINGPROTEIN, ADIPOCYTE (Homo sapiens) |
PF00061(Lipocalin) | 5 | ILE A 42CYH A 1PHE A 64PHE A 70SER A 82 | None | 1.37A | 3ko0G-1towA:0.03ko0H-1towA:undetectable3ko0I-1towA:0.03ko0J-1towA:0.0 | 3ko0G-1towA:18.183ko0H-1towA:18.183ko0I-1towA:18.183ko0J-1towA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u08 | HYPOTHETICALAMINOTRANSFERASEYBDL (Escherichiacoli) |
PF00155(Aminotran_1_2) | 5 | GLU A 117ASP A 116SER A 161ILE A 119PHE A 198 | None | 1.38A | 3ko0G-1u08A:undetectable3ko0H-1u08A:undetectable3ko0I-1u08A:0.03ko0J-1u08A:0.0 | 3ko0G-1u08A:13.173ko0H-1u08A:13.173ko0I-1u08A:13.173ko0J-1u08A:13.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v38 | SAM-DOMAIN PROTEINSAMSN-1 (Mus musculus) |
PF07647(SAM_2) | 5 | GLU A 37ASP A 40LEU A 32ILE A 15SER A 6 | None | 1.45A | 3ko0G-1v38A:undetectable3ko0H-1v38A:undetectable3ko0I-1v38A:undetectable3ko0J-1v38A:undetectable | 3ko0G-1v38A:20.373ko0H-1v38A:20.373ko0I-1v38A:20.373ko0J-1v38A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vaz | NSFL1 COFACTOR P47 (Rattusnorvegicus) |
PF08059(SEP) | 5 | ASP A 64LEU A 16SER A 22PHE A 21ILE A 43 | None | 1.46A | 3ko0G-1vazA:undetectable3ko0H-1vazA:undetectable3ko0I-1vazA:undetectable3ko0J-1vazA:undetectable | 3ko0G-1vazA:23.153ko0H-1vazA:23.153ko0I-1vazA:23.153ko0J-1vazA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybi | NON-TOXINHAEMAGGLUTININ HA34 (Clostridiumbotulinum) |
PF05588(Botulinum_HA-17)PF14200(RicinB_lectin_2) | 5 | ASP A 121LEU A 129ILE A 82PHE A 140SER A 135 | None | 1.32A | 3ko0G-1ybiA:undetectable3ko0H-1ybiA:undetectable3ko0I-1ybiA:undetectable3ko0J-1ybiA:undetectable | 3ko0G-1ybiA:14.583ko0H-1ybiA:14.583ko0I-1ybiA:14.583ko0J-1ybiA:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykw | RUBISCO-LIKE PROTEIN (Chlorobaculumtepidum) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | GLU A 181LEU A 177SER A 178PHE A 182ILE A 185 | None | 1.19A | 3ko0G-1ykwA:undetectable3ko0H-1ykwA:undetectable3ko0I-1ykwA:undetectable3ko0J-1ykwA:undetectable | 3ko0G-1ykwA:12.473ko0H-1ykwA:12.473ko0I-1ykwA:12.473ko0J-1ykwA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzm | PUTATIVEDEOXYRIBONUCLEASEYJJV (Escherichiacoli) |
PF01026(TatD_DNase) | 5 | ASP A 13LEU A 25SER A 24ILE A 36CYH A 10 | None | 1.18A | 3ko0G-1zzmA:0.03ko0H-1zzmA:undetectable3ko0I-1zzmA:0.03ko0J-1zzmA:0.0 | 3ko0G-1zzmA:14.893ko0H-1zzmA:14.893ko0I-1zzmA:14.893ko0J-1zzmA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buc | DIPEPTIDYL PEPTIDASEIV (Sus scrofa) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | ASP A 329LEU A 313ILE A 311PHE A 364PHE A 371 | None | 1.23A | 3ko0G-2bucA:undetectable3ko0H-2bucA:undetectable3ko0I-2bucA:undetectable3ko0J-2bucA:undetectable | 3ko0G-2bucA:7.573ko0H-2bucA:7.573ko0I-2bucA:7.573ko0J-2bucA:7.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1g | ACID PHOSPHATASE (Francisellatularensis) |
PF04185(Phosphoesterase) | 5 | ASP A 375SER A 339ILE A 381PHE A 326PHE A 253 | None | 1.32A | 3ko0G-2d1gA:undetectable3ko0H-2d1gA:undetectable3ko0I-2d1gA:undetectable3ko0J-2d1gA:undetectable | 3ko0G-2d1gA:11.513ko0H-2d1gA:11.513ko0I-2d1gA:11.513ko0J-2d1gA:11.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dg2 | APOLIPOPROTEIN A-IBINDING PROTEIN (Mus musculus) |
PF03853(YjeF_N) | 5 | LEU A 207SER A 186ILE A 65CYH A 97SER A 191 | None | 1.33A | 3ko0G-2dg2A:undetectable3ko0H-2dg2A:undetectable3ko0I-2dg2A:undetectable3ko0J-2dg2A:undetectable | 3ko0G-2dg2A:15.353ko0H-2dg2A:15.353ko0I-2dg2A:15.353ko0J-2dg2A:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gm8 | TENA HOMOLOG/THI-4THIAMINASE (Pyrobaculumaerophilum) |
PF03070(TENA_THI-4) | 5 | GLU A 140LEU A 18ILE A 141PHE A 135PHE A 194 | NoneNoneNoneHMH A 301 ( 4.9A)None | 1.46A | 3ko0G-2gm8A:1.33ko0H-2gm8A:1.33ko0I-2gm8A:1.33ko0J-2gm8A:1.3 | 3ko0G-2gm8A:20.233ko0H-2gm8A:20.233ko0I-2gm8A:20.233ko0J-2gm8A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nux | 2-KETO-3-DEOXYGLUCONATE/2-KETO-3-DEOXY-6-PHOSPHO GLUCONATEALDOLASE (Sulfolobusacidocaldarius) |
PF00701(DHDPS) | 5 | LEU A 186SER A 185ILE A 3PHE A 38SER A 162 | None | 1.36A | 3ko0G-2nuxA:undetectable3ko0H-2nuxA:undetectable3ko0I-2nuxA:undetectable3ko0J-2nuxA:undetectable | 3ko0G-2nuxA:16.383ko0H-2nuxA:16.383ko0I-2nuxA:16.383ko0J-2nuxA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ohh | TYPE A FLAVOPROTEINFPRA (Methanothermobacterthermautotrophicus) |
PF00258(Flavodoxin_1)PF00753(Lactamase_B) | 5 | ASP A 154LEU A 92ILE A 104ASP A 170SER A 232 | NoneNoneNone FE A 501 ( 2.3A) FE A 501 ( 3.8A) | 1.31A | 3ko0G-2ohhA:undetectable3ko0H-2ohhA:undetectable3ko0I-2ohhA:undetectable3ko0J-2ohhA:undetectable | 3ko0G-2ohhA:13.403ko0H-2ohhA:13.403ko0I-2ohhA:13.403ko0J-2ohhA:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p1i | RIBONUCLEOTIDEREDUCTASE, SMALLCHAIN (Plasmodiumyoelii) |
PF00268(Ribonuc_red_sm) | 5 | LEU A 212PHE A 206ILE A 88PHE A 94SER A 223 | None | 1.39A | 3ko0G-2p1iA:undetectable3ko0H-2p1iA:undetectable3ko0I-2p1iA:undetectable3ko0J-2p1iA:undetectable | 3ko0G-2p1iA:15.883ko0H-2p1iA:15.883ko0I-2p1iA:15.883ko0J-2p1iA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2prr | ALKYLHYDROPEROXIDASEAHPD CORE:UNCHARACTERIZEDPEROXIDASE-RELATEDPROTEIN (Cupriaviduspinatubonensis) |
PF02627(CMD) | 5 | LEU A 42ILE A 27PHE A 55PHE A 54SER A 171 | NoneNoneNoneNonePEG A 199 (-2.9A) | 1.02A | 3ko0G-2prrA:1.63ko0H-2prrA:1.83ko0I-2prrA:1.83ko0J-2prrA:1.8 | 3ko0G-2prrA:20.903ko0H-2prrA:20.903ko0I-2prrA:20.903ko0J-2prrA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pvu | ARTJ (Geobacillusstearothermophilus) |
PF00497(SBP_bac_3) | 5 | ASP A 81LEU A 71SER A 74PHE A 72ILE A 208 | None | 1.31A | 3ko0G-2pvuA:0.03ko0H-2pvuA:undetectable3ko0I-2pvuA:undetectable3ko0J-2pvuA:undetectable | 3ko0G-2pvuA:16.613ko0H-2pvuA:16.613ko0I-2pvuA:16.613ko0J-2pvuA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qhp | FRUCTOKINASE (Bacteroidesthetaiotaomicron) |
PF00294(PfkB) | 5 | GLU A 180ASP A 178LEU A 154ILE A 184PHE A 223 | None | 1.38A | 3ko0G-2qhpA:undetectable3ko0H-2qhpA:undetectable3ko0I-2qhpA:undetectable3ko0J-2qhpA:undetectable | 3ko0G-2qhpA:16.613ko0H-2qhpA:16.613ko0I-2qhpA:16.613ko0J-2qhpA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qoj | INTRON-ENCODED DNAENDONUCLEASE I-ANII (Aspergillusnidulans) |
PF00961(LAGLIDADG_1) | 5 | LEU Z 216PHE Z 215ILE Z 145PHE Z 187SER Z 205 | None | 1.41A | 3ko0G-2qojZ:undetectable3ko0H-2qojZ:undetectable3ko0I-2qojZ:undetectable3ko0J-2qojZ:undetectable | 3ko0G-2qojZ:17.933ko0H-2qojZ:17.933ko0I-2qojZ:17.933ko0J-2qojZ:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qsd | UNCHARACTERIZEDCONSERVED PROTEIN (Idiomarinaloihiensis) |
PF07566(DUF1543) | 5 | ASP A 26LEU A 55SER A 57PHE A 58ASP A 103 | None | 1.42A | 3ko0G-2qsdA:undetectable3ko0H-2qsdA:undetectable3ko0I-2qsdA:undetectable3ko0J-2qsdA:undetectable | 3ko0G-2qsdA:22.103ko0H-2qsdA:22.103ko0I-2qsdA:22.103ko0J-2qsdA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v26 | MYOSIN VI (Sus scrofa) |
PF00063(Myosin_head) | 5 | ASP A 748LEU A 738ILE A 769PHE A 705PHE A 751 | None | 1.20A | 3ko0G-2v26A:0.93ko0H-2v26A:undetectable3ko0I-2v26A:1.53ko0J-2v26A:1.4 | 3ko0G-2v26A:9.243ko0H-2v26A:9.243ko0I-2v26A:9.243ko0J-2v26A:9.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vg8 | HYDROQUINONEGLUCOSYLTRANSFERASE (Arabidopsisthaliana) |
PF00201(UDPGT) | 5 | SER A 274ILE A 343CYH A 258PHE A 361SER A 369 | UDP A1477 ( 3.7A)NoneNoneNoneUDP A1477 (-2.6A) | 1.45A | 3ko0G-2vg8A:0.03ko0H-2vg8A:undetectable3ko0I-2vg8A:0.03ko0J-2vg8A:0.0 | 3ko0G-2vg8A:12.243ko0H-2vg8A:12.243ko0I-2vg8A:12.243ko0J-2vg8A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wn4 | ADP-RIBOSYLTRANSFERASE ENZYMATICCOMPONENT (Clostridioidesdifficile) |
PF03496(ADPrib_exo_Tox) | 5 | ASP A 402LEU A 363ILE A 398PHE A 107ASP A 141 | None | 1.17A | 3ko0G-2wn4A:undetectable3ko0H-2wn4A:undetectable3ko0I-2wn4A:undetectable3ko0J-2wn4A:undetectable | 3ko0G-2wn4A:13.103ko0H-2wn4A:13.103ko0I-2wn4A:13.103ko0J-2wn4A:13.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xdf | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Escherichiacoli) |
PF00391(PEP-utilizers)PF02896(PEP-utilizers_C)PF05524(PEP-utilisers_N) | 5 | GLU A 167ASP A 148LEU A 163SER A 166PHE A 73 | None | 1.24A | 3ko0G-2xdfA:0.03ko0H-2xdfA:undetectable3ko0I-2xdfA:0.03ko0J-2xdfA:0.0 | 3ko0G-2xdfA:12.153ko0H-2xdfA:12.153ko0I-2xdfA:12.153ko0J-2xdfA:12.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zai | OLIGOSACCHARYLTRANSFERASE STT3SUBUNIT RELATEDPROTEIN (Pyrococcusfuriosus) |
no annotation | 5 | ASP A 763LEU A 815ILE A 757PHE A 724ASP A 556 | None | 0.95A | 3ko0G-2zaiA:undetectable3ko0H-2zaiA:undetectable3ko0I-2zaiA:undetectable3ko0J-2zaiA:undetectable | 3ko0G-2zaiA:10.473ko0H-2zaiA:10.473ko0I-2zaiA:10.473ko0J-2zaiA:10.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayr | ENDOGLUCANASE (Piromycesrhizinflatus) |
PF00150(Cellulase) | 5 | LEU A 107PHE A 149ILE A 136PHE A 182SER A 227 | None | 1.29A | 3ko0G-3ayrA:undetectable3ko0H-3ayrA:undetectable3ko0I-3ayrA:undetectable3ko0J-3ayrA:undetectable | 3ko0G-3ayrA:14.803ko0H-3ayrA:14.803ko0I-3ayrA:14.803ko0J-3ayrA:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e13 | PUTATIVE IRON-UPTAKEABC TRANSPORTSYSTEM,PERIPLASMICIRON-BINDING PROTEIN (Campylobacterjejuni) |
PF13343(SBP_bac_6) | 5 | PHE X 100ILE X 88PHE X 259ASP X 18SER X 11 | None | 1.30A | 3ko0G-3e13X:0.03ko0H-3e13X:undetectable3ko0I-3e13X:undetectable3ko0J-3e13X:undetectable | 3ko0G-3e13X:16.673ko0H-3e13X:16.673ko0I-3e13X:16.673ko0J-3e13X:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e13 | PUTATIVE IRON-UPTAKEABC TRANSPORTSYSTEM,PERIPLASMICIRON-BINDING PROTEIN (Campylobacterjejuni) |
PF13343(SBP_bac_6) | 5 | SER X 239ILE X 278PHE X 259ASP X 18SER X 11 | None | 1.23A | 3ko0G-3e13X:0.03ko0H-3e13X:undetectable3ko0I-3e13X:undetectable3ko0J-3e13X:undetectable | 3ko0G-3e13X:16.673ko0H-3e13X:16.673ko0I-3e13X:16.673ko0J-3e13X:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eaf | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (Aeropyrumpernix) |
PF13458(Peripla_BP_6) | 5 | SER A 171PHE A 410ILE A 395PHE A 298ASP A 164 | None | 1.16A | 3ko0G-3eafA:undetectable3ko0H-3eafA:undetectable3ko0I-3eafA:undetectable3ko0J-3eafA:undetectable | 3ko0G-3eafA:12.923ko0H-3eafA:12.923ko0I-3eafA:12.923ko0J-3eafA:12.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktc | XYLOSE ISOMERASE (Pectobacteriumatrosepticum) |
PF01261(AP_endonuc_2) | 5 | ASP A 229LEU A 289SER A 285PHE A 288ILE A 251 | FE A 334 (-3.1A)NoneNoneNoneNone | 1.21A | 3ko0G-3ktcA:undetectable3ko0H-3ktcA:undetectable3ko0I-3ktcA:undetectable3ko0J-3ktcA:undetectable | 3ko0G-3ktcA:16.223ko0H-3ktcA:16.223ko0I-3ktcA:16.223ko0J-3ktcA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lb6 | INTERLEUKIN-13 (Homo sapiens) |
PF03487(IL13) | 5 | GLU A 49LEU A 83SER A 82ILE A 37PHE A 70 | None | 1.42A | 3ko0G-3lb6A:undetectable3ko0H-3lb6A:undetectable3ko0I-3lb6A:undetectable3ko0J-3lb6A:undetectable | 3ko0G-3lb6A:21.583ko0H-3lb6A:21.583ko0I-3lb6A:21.583ko0J-3lb6A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqv | ALBC (Streptomycesnoursei) |
PF16715(CDPS) | 5 | ASP A 205LEU A 212SER A 213PHE A 211ILE A 208 | NoneNoneNoneNoneDTD A 248 ( 4.1A) | 1.29A | 3ko0G-3oqvA:undetectable3ko0H-3oqvA:undetectable3ko0I-3oqvA:undetectable3ko0J-3oqvA:undetectable | 3ko0G-3oqvA:15.733ko0H-3oqvA:15.733ko0I-3oqvA:15.733ko0J-3oqvA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qan | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE1 (Bacillushalodurans) |
PF00171(Aldedh) | 5 | LEU A 185SER A 116PHE A 115ILE A 108PHE A 22 | None | 1.18A | 3ko0G-3qanA:undetectable3ko0H-3qanA:undetectable3ko0I-3qanA:undetectable3ko0J-3qanA:undetectable | 3ko0G-3qanA:12.483ko0H-3qanA:12.483ko0I-3qanA:12.483ko0J-3qanA:12.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rre | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermotogamaritima) |
PF01256(Carb_kinase)PF03853(YjeF_N) | 5 | ASP A 344LEU A 332PHE A 331ILE A 314PHE A 293 | None | 1.39A | 3ko0G-3rreA:undetectable3ko0H-3rreA:undetectable3ko0I-3rreA:undetectable3ko0J-3rreA:undetectable | 3ko0G-3rreA:11.383ko0H-3rreA:11.383ko0I-3rreA:11.383ko0J-3rreA:11.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upy | OXIDOREDUCTASE (Brucellaabortus) |
PF03447(NAD_binding_3) | 5 | LEU A 242SER A 188ILE A 236PHE A 291SER A 260 | None | 1.42A | 3ko0G-3upyA:undetectable3ko0H-3upyA:undetectable3ko0I-3upyA:undetectable3ko0J-3upyA:undetectable | 3ko0G-3upyA:12.683ko0H-3upyA:12.683ko0I-3upyA:12.683ko0J-3upyA:12.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upy | OXIDOREDUCTASE (Brucellaabortus) |
PF03447(NAD_binding_3) | 5 | SER A 188ILE A 236CYH A 172PHE A 291SER A 260 | None | 1.37A | 3ko0G-3upyA:undetectable3ko0H-3upyA:undetectable3ko0I-3upyA:undetectable3ko0J-3upyA:undetectable | 3ko0G-3upyA:12.683ko0H-3upyA:12.683ko0I-3upyA:12.683ko0J-3upyA:12.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vu1 | PUTATIVEUNCHARACTERIZEDPROTEIN PH0242 (Pyrococcushorikoshii) |
no annotation | 5 | ASP A 769LEU A 821ILE A 763PHE A 730ASP A 558 | None | 1.00A | 3ko0G-3vu1A:undetectable3ko0H-3vu1A:undetectable3ko0I-3vu1A:undetectable3ko0J-3vu1A:undetectable | 3ko0G-3vu1A:11.063ko0H-3vu1A:11.063ko0I-3vu1A:11.063ko0J-3vu1A:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnp | CYCLOISOMALTOOLIGOSACCHARIDEGLUCANOTRANSFERASE (Bacilluscirculans) |
PF13199(Glyco_hydro_66)PF16990(CBM_35) | 5 | LEU A 334PHE A 333ILE A 236PHE A 264ASP A 325 | None | 1.14A | 3ko0G-3wnpA:undetectable3ko0H-3wnpA:undetectable3ko0I-3wnpA:undetectable3ko0J-3wnpA:undetectable | 3ko0G-3wnpA:9.043ko0H-3wnpA:9.043ko0I-3wnpA:9.043ko0J-3wnpA:9.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wov | OLIGOSACCHARYLTRANSFERASE (Pyrococcusabyssi) |
no annotation | 5 | ASP A 771LEU A 821ILE A 765PHE A 732ASP A 559 | None | 0.98A | 3ko0G-3wovA:undetectable3ko0H-3wovA:undetectable3ko0I-3wovA:undetectable3ko0J-3wovA:undetectable | 3ko0G-3wovA:9.963ko0H-3wovA:9.963ko0I-3wovA:9.963ko0J-3wovA:9.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wry | TM-1 PROTEIN (Solanumlycopersicum) |
PF06792(UPF0261) | 5 | LEU A 107ILE A 14PHE A 167ASP A 163SER A 162 | None | 1.37A | 3ko0G-3wryA:undetectable3ko0H-3wryA:undetectable3ko0I-3wryA:undetectable3ko0J-3wryA:undetectable | 3ko0G-3wryA:12.533ko0H-3wryA:12.533ko0I-3wryA:12.533ko0J-3wryA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 5 | GLU A 747LEU A 232ILE A 107PHE A 99PHE A 240 | NoneNoneNoneDMU A1776 (-4.5A)None | 1.39A | 3ko0G-4a01A:undetectable3ko0H-4a01A:1.23ko0I-4a01A:1.83ko0J-4a01A:1.7 | 3ko0G-4a01A:8.763ko0H-4a01A:8.763ko0I-4a01A:8.763ko0J-4a01A:8.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4anj | UNCONVENTIONALMYOSIN-VI, GREENFLUORESCENT PROTEIN (Aequoreavictoria;Sus scrofa) |
PF00063(Myosin_head)PF01353(GFP) | 5 | ASP A 748LEU A 738ILE A 769PHE A 705PHE A 751 | None | 1.28A | 3ko0G-4anjA:undetectable3ko0H-4anjA:undetectable3ko0I-4anjA:undetectable3ko0J-4anjA:undetectable | 3ko0G-4anjA:6.933ko0H-4anjA:6.933ko0I-4anjA:6.933ko0J-4anjA:6.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ay1 | CHITINASE-3-LIKEPROTEIN 2 (Homo sapiens) |
PF00704(Glyco_hydro_18) | 5 | LEU A 99SER A 62ILE A 73ASP A 363SER A 361 | None | 1.41A | 3ko0G-4ay1A:undetectable3ko0H-4ay1A:undetectable3ko0I-4ay1A:undetectable3ko0J-4ay1A:undetectable | 3ko0G-4ay1A:13.703ko0H-4ay1A:13.703ko0I-4ay1A:13.703ko0J-4ay1A:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc5 | XYLULOSE KINASE (Homo sapiens) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ASP A 14LEU A 72ILE A 75PHE A 39SER A 63 | None | 1.38A | 3ko0G-4bc5A:undetectable3ko0H-4bc5A:undetectable3ko0I-4bc5A:undetectable3ko0J-4bc5A:undetectable | 3ko0G-4bc5A:11.783ko0H-4bc5A:11.783ko0I-4bc5A:11.783ko0J-4bc5A:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhd | SERINEHYDROXYMETHYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF00464(SHMT) | 5 | ASP A 318LEU A 332PHE A 327ILE A 325ASP A 351 | None | 1.29A | 3ko0G-4bhdA:undetectable3ko0H-4bhdA:undetectable3ko0I-4bhdA:undetectable3ko0J-4bhdA:undetectable | 3ko0G-4bhdA:12.383ko0H-4bhdA:12.383ko0I-4bhdA:12.383ko0J-4bhdA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bqn | CAPSULARPOLYSACCHARIDEBIOSYNTHESIS PROTEIN (Burkholderiapseudomallei) |
no annotation | 5 | ASP A 179LEU A 19ILE A 210ASP A 173SER A 79 | None | 1.44A | 3ko0G-4bqnA:undetectable3ko0H-4bqnA:undetectable3ko0I-4bqnA:undetectable3ko0J-4bqnA:undetectable | 3ko0G-4bqnA:17.383ko0H-4bqnA:17.383ko0I-4bqnA:17.383ko0J-4bqnA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4chl | PERSULFIDEDIOXYGENASE ETHE1,MITOCHONDRIAL (Homo sapiens) |
PF00753(Lactamase_B) | 5 | GLU A 221LEU A 217SER A 218PHE A 222ILE A 225 | None | 1.14A | 3ko0G-4chlA:undetectable3ko0H-4chlA:undetectable3ko0I-4chlA:undetectable3ko0J-4chlA:undetectable | 3ko0G-4chlA:16.323ko0H-4chlA:16.323ko0I-4chlA:16.323ko0J-4chlA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dkb | DEOXYURIDINETRIPHOSPHATASE (Trypanosomabrucei) |
PF08761(dUTPase_2) | 5 | ASP A 163LEU A 70ILE A 197PHE A 158PHE A 171 | None | 1.35A | 3ko0G-4dkbA:undetectable3ko0H-4dkbA:undetectable3ko0I-4dkbA:undetectable3ko0J-4dkbA:undetectable | 3ko0G-4dkbA:14.733ko0H-4dkbA:14.733ko0I-4dkbA:14.733ko0J-4dkbA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dth | VGRG PROTEIN (Vibrio cholerae) |
PF16671(ACD) | 5 | ASP A 87LEU A 347SER A 349ILE A 13CYH A 84 | None | 1.40A | 3ko0G-4dthA:undetectable3ko0H-4dthA:undetectable3ko0I-4dthA:undetectable3ko0J-4dthA:undetectable | 3ko0G-4dthA:13.443ko0H-4dthA:13.443ko0I-4dthA:13.443ko0J-4dthA:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eco | UNCHARACTERIZEDPROTEIN (Bacteroideseggerthii) |
no annotation | 5 | ASP A 676LEU A 727SER A 729PHE A 426ASP A 421 | None | 1.28A | 3ko0G-4ecoA:undetectable3ko0H-4ecoA:undetectable3ko0I-4ecoA:undetectable3ko0J-4ecoA:undetectable | 3ko0G-4ecoA:11.073ko0H-4ecoA:11.073ko0I-4ecoA:11.073ko0J-4ecoA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fid | G PROTEIN ALPHASUBUNIT (Entamoebahistolytica) |
PF00503(G-alpha) | 5 | GLU A 214LEU A 228SER A 231ILE A 288PHE A 252 | None | 1.28A | 3ko0G-4fidA:undetectable3ko0H-4fidA:undetectable3ko0I-4fidA:undetectable3ko0J-4fidA:undetectable | 3ko0G-4fidA:15.163ko0H-4fidA:15.163ko0I-4fidA:15.163ko0J-4fidA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fid | G PROTEIN ALPHASUBUNIT (Entamoebahistolytica) |
PF00503(G-alpha) | 5 | GLU A 214LEU A 228SER A 231PHE A 252PHE A 208 | None | 1.20A | 3ko0G-4fidA:undetectable3ko0H-4fidA:undetectable3ko0I-4fidA:undetectable3ko0J-4fidA:undetectable | 3ko0G-4fidA:15.163ko0H-4fidA:15.163ko0I-4fidA:15.163ko0J-4fidA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwt | THREONINE--TRNALIGASE, CYTOPLASMIC (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | LEU A 596ILE A 509CYH A 512PHE A 515ASP A 495 | NoneNoneNoneNone1B2 A 802 (-3.6A) | 1.24A | 3ko0G-4hwtA:0.83ko0H-4hwtA:1.03ko0I-4hwtA:1.13ko0J-4hwtA:1.1 | 3ko0G-4hwtA:14.493ko0H-4hwtA:14.493ko0I-4hwtA:14.493ko0J-4hwtA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ihq | FLAI ATPASE (Sulfolobusacidocaldarius) |
PF00437(T2SSE) | 5 | GLU A 68ASP A 67LEU A 109SER A 110ILE A 72 | None | 1.44A | 3ko0G-4ihqA:undetectable3ko0H-4ihqA:undetectable3ko0I-4ihqA:undetectable3ko0J-4ihqA:undetectable | 3ko0G-4ihqA:11.983ko0H-4ihqA:11.983ko0I-4ihqA:11.983ko0J-4ihqA:11.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k37 | ANAEROBICSULFATASE-MATURATINGENZYME (Clostridiumperfringens) |
PF04055(Radical_SAM)PF13186(SPASM)PF13353(Fer4_12) | 5 | ASP A 270LEU A 44SER A 46ILE A 8ASP A 291 | None | 1.34A | 3ko0G-4k37A:undetectable3ko0H-4k37A:undetectable3ko0I-4k37A:undetectable3ko0J-4k37A:undetectable | 3ko0G-4k37A:15.143ko0H-4k37A:15.143ko0I-4k37A:15.143ko0J-4k37A:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ktp | GLYCOSIDE HYDROLASEFAMILY 65 CENTRALCATALYTIC ([Bacillus]selenitireducens) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 5 | GLU A 336ASP A 419LEU A 355PHE A 451SER A 383 | None | 1.41A | 3ko0G-4ktpA:undetectable3ko0H-4ktpA:undetectable3ko0I-4ktpA:undetectable3ko0J-4ktpA:undetectable | 3ko0G-4ktpA:7.743ko0H-4ktpA:7.743ko0I-4ktpA:7.743ko0J-4ktpA:7.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kws | D-MANNONATEDEHYDRATASE (Chromohalobactersalexigens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASP A 97LEU A 289PHE A 331ILE A 295ASP A 357 | None | 1.24A | 3ko0G-4kwsA:undetectable3ko0H-4kwsA:undetectable3ko0I-4kwsA:undetectable3ko0J-4kwsA:undetectable | 3ko0G-4kwsA:13.823ko0H-4kwsA:13.823ko0I-4kwsA:13.823ko0J-4kwsA:13.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mnd | CTPL-MYO-INOSITOL-1-PHOSPHATECYTIDYLYLTRANSFERASE/CDP-L-MYO-INOSITOLMYO-INOSITOLPHOSPHOTRANSFERASE (Archaeoglobusfulgidus) |
PF01066(CDP-OH_P_transf)PF12804(NTP_transf_3) | 5 | GLU A 362SER A 308ILE A 363ASP A 296SER A 300 | None | 1.35A | 3ko0G-4mndA:undetectable3ko0H-4mndA:undetectable3ko0I-4mndA:undetectable3ko0J-4mndA:undetectable | 3ko0G-4mndA:12.843ko0H-4mndA:12.843ko0I-4mndA:12.843ko0J-4mndA:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nt9 | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcuspneumoniae) |
no annotation | 5 | LEU B 82SER B 151ILE B 74PHE B 187ASP B 160 | NoneACT B 302 (-2.6A)NoneNone ZN B 301 (-2.5A) | 1.47A | 3ko0G-4nt9B:undetectable3ko0H-4nt9B:undetectable3ko0I-4nt9B:undetectable3ko0J-4nt9B:undetectable | 3ko0G-4nt9B:16.823ko0H-4nt9B:16.823ko0I-4nt9B:16.823ko0J-4nt9B:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ojz | PUTATIVE ALGINATELYASE (Saccharophagusdegradans) |
PF05426(Alginate_lyase)PF07940(Hepar_II_III) | 5 | LEU A 227SER A 226PHE A 238ILE A 273SER A 189 | None | 1.24A | 3ko0G-4ojzA:undetectable3ko0H-4ojzA:undetectable3ko0I-4ojzA:undetectable3ko0J-4ojzA:undetectable | 3ko0G-4ojzA:8.973ko0H-4ojzA:8.973ko0I-4ojzA:8.973ko0J-4ojzA:8.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ouj | HEMAGGLUTININCOMPONENT HA33 (Clostridiumbotulinum) |
PF14200(RicinB_lectin_2) | 5 | ASP A 123LEU A 131ILE A 84PHE A 142SER A 137 | None | 1.41A | 3ko0G-4oujA:undetectable3ko0H-4oujA:undetectable3ko0I-4oujA:undetectable3ko0J-4oujA:undetectable | 3ko0G-4oujA:15.313ko0H-4oujA:15.313ko0I-4oujA:15.313ko0J-4oujA:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p5w | CALCIUM-BINDINGMITOCHONDRIALCARRIER PROTEINARALAR2,CALCIUM-BINDING MITOCHONDRIALCARRIER PROTEINARALAR2 (Homo sapiens) |
no annotation | 5 | LEU A 72PHE A 34ILE A 27PHE A 21PHE A 78 | None | 1.39A | 3ko0G-4p5wA:4.53ko0H-4p5wA:4.33ko0I-4p5wA:5.43ko0J-4p5wA:5.3 | 3ko0G-4p5wA:13.793ko0H-4p5wA:13.793ko0I-4p5wA:13.793ko0J-4p5wA:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pwy | CALMODULIN-LYSINEN-METHYLTRANSFERASE (Homo sapiens) |
PF10294(Methyltransf_16) | 5 | GLU A 132LEU A 70SER A 67ILE A 292PHE A 65 | UNX A 420 ( 3.3A)NoneUNX A 420 ( 3.0A)NoneUNX A 408 ( 4.8A) | 1.21A | 3ko0G-4pwyA:undetectable3ko0H-4pwyA:undetectable3ko0I-4pwyA:undetectable3ko0J-4pwyA:undetectable | 3ko0G-4pwyA:18.853ko0H-4pwyA:18.853ko0I-4pwyA:18.853ko0J-4pwyA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdg | PUTATIVE ADHESIN (Bacteroidesthetaiotaomicron) |
PF08842(Mfa2) | 5 | ASP A 205LEU A 254SER A 252PHE A 209PHE A 119 | None | 1.42A | 3ko0G-4qdgA:undetectable3ko0H-4qdgA:undetectable3ko0I-4qdgA:undetectable3ko0J-4qdgA:undetectable | 3ko0G-4qdgA:17.323ko0H-4qdgA:17.323ko0I-4qdgA:17.323ko0J-4qdgA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qla | JUVENILE HORMONEEPOXIDE HYDROLASE (Bombyx mori) |
PF06441(EHN) | 5 | LEU A 386SER A 234ILE A 389PHE A 247SER A 249 | None | 1.39A | 3ko0G-4qlaA:undetectable3ko0H-4qlaA:undetectable3ko0I-4qlaA:undetectable3ko0J-4qlaA:undetectable | 3ko0G-4qlaA:12.023ko0H-4qlaA:12.023ko0I-4qlaA:12.023ko0J-4qlaA:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rcm | METHYLATEDRNA-BINDING PROTEIN1 (Saccharomycescerevisiae) |
PF04146(YTH) | 5 | LEU A 289ILE A 251PHE A 204PHE A 203PHE A 157 | None | 1.37A | 3ko0G-4rcmA:undetectable3ko0H-4rcmA:undetectable3ko0I-4rcmA:undetectable3ko0J-4rcmA:undetectable | 3ko0G-4rcmA:22.023ko0H-4rcmA:22.023ko0I-4rcmA:22.023ko0J-4rcmA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rh7 | GREEN FLUORESCENTPROTEIN/CYTOPLASMICDYNEIN 2 HEAVY CHAIN1 (Homo sapiens;syntheticconstruct) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | GLU A2530LEU A2506ILE A2526PHE A2572ASP A2537 | None | 1.40A | 3ko0G-4rh7A:undetectable3ko0H-4rh7A:undetectable3ko0I-4rh7A:undetectable3ko0J-4rh7A:undetectable | 3ko0G-4rh7A:2.913ko0H-4rh7A:2.913ko0I-4rh7A:2.913ko0J-4rh7A:2.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u3t | PENICILLIN-BINDINGPROTEIN 2 (Neisseriagonorrhoeae) |
PF00905(Transpeptidase) | 5 | SER A 368ILE A 413PHE A 420ASP A 346SER A 363 | None | 1.21A | 3ko0G-4u3tA:undetectable3ko0H-4u3tA:undetectable3ko0I-4u3tA:undetectable3ko0J-4u3tA:undetectable | 3ko0G-4u3tA:15.763ko0H-4u3tA:15.763ko0I-4u3tA:15.763ko0J-4u3tA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upi | SULFATASE FAMILYPROTEIN (Ruegeriapomeroyi) |
PF00884(Sulfatase) | 5 | GLU A 261ASP A 473LEU A 262SER A 258ASP A 467 | None | 1.47A | 3ko0G-4upiA:undetectable3ko0H-4upiA:undetectable3ko0I-4upiA:undetectable3ko0J-4upiA:undetectable | 3ko0G-4upiA:10.663ko0H-4upiA:10.663ko0I-4upiA:10.663ko0J-4upiA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzz | PUTATIVE SUGAR ABCTRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Lachnoclostridiumphytofermentans) |
PF13407(Peripla_BP_4) | 5 | GLU A 356ASP A 281PHE A 355ILE A 360ASP A 169 | NoneNoneEDO A 403 ( 4.8A)NoneNone | 1.27A | 3ko0G-4wzzA:undetectable3ko0H-4wzzA:undetectable3ko0I-4wzzA:undetectable3ko0J-4wzzA:undetectable | 3ko0G-4wzzA:13.013ko0H-4wzzA:13.013ko0I-4wzzA:13.013ko0J-4wzzA:13.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yom | SERINE/THREONINE-PROTEIN KINASE BRSK2 (Mus musculus) |
no annotation | 5 | ASP A 593LEU A 634ILE A 551PHE A 590PHE A 623 | None | 1.27A | 3ko0G-4yomA:undetectable3ko0H-4yomA:undetectable3ko0I-4yomA:undetectable3ko0J-4yomA:undetectable | 3ko0G-4yomA:18.443ko0H-4yomA:18.443ko0I-4yomA:18.443ko0J-4yomA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ah5 | LEUCINE--TRNA LIGASE (Agrobacteriumtumefaciens) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF13603(tRNA-synt_1_2) | 5 | GLU A 724LEU A 735ILE A 21PHE A 115ASP A 593 | None | 1.25A | 3ko0G-5ah5A:undetectable3ko0H-5ah5A:undetectable3ko0I-5ah5A:undetectable3ko0J-5ah5A:undetectable | 3ko0G-5ah5A:7.863ko0H-5ah5A:7.863ko0I-5ah5A:7.863ko0J-5ah5A:7.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aza | MALTOSE-BINDINGPERIPLASMICPROTEIN,OLIGOSACCHARYL TRANSFERASE STT3SUBUNIT RELATEDPROTEIN (Escherichiacoli;Pyrococcusfuriosus) |
PF13416(SBP_bac_8) | 5 | ASP A 661LEU A 713ILE A 655PHE A 622ASP A 454 | None | 0.93A | 3ko0G-5azaA:undetectable3ko0H-5azaA:undetectable3ko0I-5azaA:undetectable3ko0J-5azaA:undetectable | 3ko0G-5azaA:8.493ko0H-5azaA:8.493ko0I-5azaA:8.493ko0J-5azaA:8.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwa | ORNITHINEDECARBOXYLASEORNITHINEDECARBOXYLASEANTIZYME 1 (Homo sapiens) |
PF00278(Orn_DAP_Arg_deC)PF02100(ODC_AZ)PF02784(Orn_Arg_deC_N) | 5 | SER B 191PHE B 195ILE B 174PHE B 192ASP A 332 | NoneNoneNonePLP A 600 ( 4.4A)None | 1.42A | 3ko0G-5bwaB:undetectable3ko0H-5bwaB:undetectable3ko0I-5bwaB:undetectable3ko0J-5bwaB:undetectable | 3ko0G-5bwaB:21.473ko0H-5bwaB:21.473ko0I-5bwaB:21.473ko0J-5bwaB:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyk | RIBOSOME BIOGENESISPROTEIN YTM1 (Chaetomiumthermophilum) |
PF00400(WD40)PF08154(NLE) | 5 | GLU A 23LEU A 26ILE A 61ASP A 417SER A 403 | None | 1.29A | 3ko0G-5cykA:undetectable3ko0H-5cykA:undetectable3ko0I-5cykA:undetectable3ko0J-5cykA:undetectable | 3ko0G-5cykA:10.913ko0H-5cykA:10.913ko0I-5cykA:10.913ko0J-5cykA:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dvj | BINDING PROTEINCOMPONENT OF ABCSUGAR TRANSPORTER (Pseudomonasputida) |
PF01547(SBP_bac_1) | 5 | ASP A 303ILE A 128PHE A 298ASP A 269SER A 360 | GAL A 501 (-2.8A)NoneNoneNoneNone | 0.96A | 3ko0G-5dvjA:undetectable3ko0H-5dvjA:undetectable3ko0I-5dvjA:undetectable3ko0J-5dvjA:undetectable | 3ko0G-5dvjA:11.483ko0H-5dvjA:11.483ko0I-5dvjA:11.483ko0J-5dvjA:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyh | UNCHARACTERIZEDPROTEIN (Streptomycesvenezuelae) |
PF11583(AurF) | 5 | LEU A 94SER A 95PHE A 69ILE A 74SER A 164 | None | 1.13A | 3ko0G-5hyhA:undetectable3ko0H-5hyhA:undetectable3ko0I-5hyhA:undetectable3ko0J-5hyhA:undetectable | 3ko0G-5hyhA:14.193ko0H-5hyhA:14.193ko0I-5hyhA:14.193ko0J-5hyhA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyh | UNCHARACTERIZEDPROTEIN (Streptomycesvenezuelae) |
PF11583(AurF) | 5 | SER A 95PHE A 69ILE A 74PHE A 166SER A 164 | None | 1.21A | 3ko0G-5hyhA:undetectable3ko0H-5hyhA:undetectable3ko0I-5hyhA:undetectable3ko0J-5hyhA:undetectable | 3ko0G-5hyhA:14.193ko0H-5hyhA:14.193ko0I-5hyhA:14.193ko0J-5hyhA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzg | F-BOX/LRR-REPEATMAX2 HOMOLOG (Oryza sativa) |
no annotation | 5 | ASP B 376LEU B 361SER B 386CYH B 381ASP B 397 | None | 1.25A | 3ko0G-5hzgB:undetectable3ko0H-5hzgB:undetectable3ko0I-5hzgB:undetectable3ko0J-5hzgB:undetectable | 3ko0G-5hzgB:8.733ko0H-5hzgB:8.733ko0I-5hzgB:8.733ko0J-5hzgB:8.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2q | EF-HANDDOMAIN-CONTAININGPROTEIN D2 (Homo sapiens) |
PF13405(EF-hand_6) | 5 | LEU A 148SER A 149PHE A 153ILE A 156PHE A 80 | None | 1.40A | 3ko0G-5i2qA:7.03ko0H-5i2qA:7.33ko0I-5i2qA:7.23ko0J-5i2qA:7.3 | 3ko0G-5i2qA:25.553ko0H-5i2qA:25.553ko0I-5i2qA:25.553ko0J-5i2qA:25.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iud | DNA POLYMERASE ALPHACATALYTIC SUBUNIT (Homo sapiens) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | GLU A 350ASP A 351LEU A 484SER A 483PHE A 487 | None | 1.12A | 3ko0G-5iudA:undetectable3ko0H-5iudA:undetectable3ko0I-5iudA:undetectable3ko0J-5iudA:undetectable | 3ko0G-5iudA:7.873ko0H-5iudA:7.873ko0I-5iudA:7.873ko0J-5iudA:7.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k04 | UNCHARACTERIZEDPROTEIN (Candidaalbicans) |
PF09797(NatB_MDM20) | 5 | GLU A 94SER A 90ILE A 97CYH A 108PHE A 112 | None | 1.33A | 3ko0G-5k04A:undetectable3ko0H-5k04A:undetectable3ko0I-5k04A:undetectable3ko0J-5k04A:undetectable | 3ko0G-5k04A:9.643ko0H-5k04A:9.643ko0I-5k04A:9.643ko0J-5k04A:9.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ksh | PENICILLIN-BINDINGPROTEIN 2 (Neisseriagonorrhoeae) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | SER A 368ILE A 413PHE A 420ASP A 346SER A 363 | None | 1.23A | 3ko0G-5kshA:undetectable3ko0H-5kshA:undetectable3ko0I-5kshA:undetectable3ko0J-5kshA:undetectable | 3ko0G-5kshA:10.703ko0H-5kshA:10.703ko0I-5kshA:10.703ko0J-5kshA:10.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lnb | UBIQUITIN-LIKE-SPECIFIC PROTEASE 2 (Saccharomycescerevisiae) |
PF02902(Peptidase_C48) | 5 | LEU B 91PHE B 185ILE B 182CYH B 130ASP B 59 | None | 1.39A | 3ko0G-5lnbB:undetectable3ko0H-5lnbB:undetectable3ko0I-5lnbB:undetectable3ko0J-5lnbB:undetectable | 3ko0G-5lnbB:16.503ko0H-5lnbB:16.503ko0I-5lnbB:16.503ko0J-5lnbB:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpm | SARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 2 (Sus scrofa) |
no annotation | 5 | GLU A 309LEU A 65ILE A 94ASP A 799SER A 766 | NoneCZA A1002 (-4.1A)NoneNoneNone | 1.34A | 3ko0G-5mpmA:undetectable3ko0H-5mpmA:undetectable3ko0I-5mpmA:undetectable3ko0J-5mpmA:undetectable | 3ko0G-5mpmA:24.473ko0H-5mpmA:24.473ko0I-5mpmA:24.473ko0J-5mpmA:24.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6m | APOLIPOPROTEINN-ACYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00795(CN_hydrolase) | 5 | GLU A 135LEU A 132SER A 172PHE A 173SER A 153 | None | 1.36A | 3ko0G-5n6mA:1.53ko0H-5n6mA:0.93ko0I-5n6mA:1.63ko0J-5n6mA:1.4 | 3ko0G-5n6mA:10.323ko0H-5n6mA:10.323ko0I-5n6mA:10.323ko0J-5n6mA:10.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5osb | PROTON-GATED IONCHANNEL,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1 (Gloeobacterviolaceus;Mus musculus) |
no annotation | 5 | LEU A 401ILE A 405PHE A 288PHE A 295SER A 240 | None | 1.45A | 3ko0G-5osbA:1.83ko0H-5osbA:1.53ko0I-5osbA:undetectable3ko0J-5osbA:1.5 | 3ko0G-5osbA:15.943ko0H-5osbA:15.943ko0I-5osbA:15.943ko0J-5osbA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tvo | S-ADENOSYLMETHIONINEDECARBOXYLASEPROENZYME (Trypanosomabrucei) |
PF01536(SAM_decarbox) | 5 | SER A 193ILE A 98PHE A 128PHE A 304ASP A 169 | None | 1.34A | 3ko0G-5tvoA:undetectable3ko0H-5tvoA:undetectable3ko0I-5tvoA:undetectable3ko0J-5tvoA:undetectable | 3ko0G-5tvoA:16.793ko0H-5tvoA:16.793ko0I-5tvoA:16.793ko0J-5tvoA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uin | FORMYLTRANSFERASE (Salmonellaenterica) |
PF00551(Formyl_trans_N)PF13637(Ank_4) | 5 | LEU A 297SER A 295ILE A 275PHE A 232ASP A 235 | None | 1.24A | 3ko0G-5uinA:undetectable3ko0H-5uinA:undetectable3ko0I-5uinA:undetectable3ko0J-5uinA:undetectable | 3ko0G-5uinA:13.033ko0H-5uinA:13.033ko0I-5uinA:13.033ko0J-5uinA:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uxv | SENSORY TRANSDUCTIONREGULATORY PROTEIN (Bartonellaquintana) |
no annotation | 5 | LEU A 127PHE A 99ILE A 102ASP A 65SER A 89 | None | 1.04A | 3ko0G-5uxvA:undetectable3ko0H-5uxvA:undetectable3ko0I-5uxvA:undetectable3ko0J-5uxvA:undetectable | 3ko0G-5uxvA:17.593ko0H-5uxvA:17.593ko0I-5uxvA:17.593ko0J-5uxvA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgu | RIBONUCLEASE R (Escherichiacoli) |
no annotation | 5 | PHE B 552ILE B 582PHE B 350PHE B 352SER B 241 | None | 1.43A | 3ko0G-5xguB:undetectable3ko0H-5xguB:undetectable3ko0I-5xguB:undetectable3ko0J-5xguB:undetectable | 3ko0G-5xguB:10.733ko0H-5xguB:10.733ko0I-5xguB:10.733ko0J-5xguB:10.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y82 | MEMBRANE PROTEININSERTASE YIDC (Thermotogamaritima) |
no annotation | 5 | ASP D 209LEU D 169PHE D 193ILE D 202PHE D 127 | None | 1.43A | 3ko0G-5y82D:undetectable3ko0H-5y82D:undetectable3ko0I-5y82D:undetectable3ko0J-5y82D:undetectable | 3ko0G-5y82D:20.623ko0H-5y82D:20.623ko0I-5y82D:20.623ko0J-5y82D:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cet | GATOR COMPLEXPROTEIN DEPDC5GATOR COMPLEXPROTEIN NPRL2 (Homo sapiens) |
no annotation | 5 | GLU D 344ASP D 395SER D 301PHE D 343SER N 187 | None | 1.38A | 3ko0G-6cetD:undetectable3ko0H-6cetD:undetectable3ko0I-6cetD:undetectable3ko0J-6cetD:undetectable | 3ko0G-6cetD:19.613ko0H-6cetD:19.613ko0I-6cetD:19.613ko0J-6cetD:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6u | GAMMA-AMINOBUTYRICACID RECEPTORSUBUNITALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTORSUBUNIT ALPHA-1 (Homo sapiens) |
no annotation | 5 | LEU B 331ILE B 335PHE B 289PHE B 296SER B 241 | None | 1.36A | 3ko0G-6d6uB:1.93ko0H-6d6uB:undetectable3ko0I-6d6uB:undetectable3ko0J-6d6uB:undetectable | 3ko0G-6d6uB:20.393ko0H-6d6uB:20.393ko0I-6d6uB:20.393ko0J-6d6uB:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6evj | RNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Avirus) |
no annotation | 5 | LEU B 102PHE B 103ILE B 262PHE B 254ASP B 112 | None | 1.14A | 3ko0G-6evjB:undetectable3ko0H-6evjB:undetectable3ko0I-6evjB:undetectable3ko0J-6evjB:undetectable | 3ko0G-6evjB:17.923ko0H-6evjB:17.923ko0I-6evjB:17.923ko0J-6evjB:17.92 |