SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_H_TFPH202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 ASP A 145
LEU A 142
PHE A  86
ILE A  18
SER A 130
 None
 1.19A 3ko0G-1ag9A:
undetectable
3ko0H-1ag9A:
undetectable
3ko0I-1ag9A:
undetectable
3ko0J-1ag9A:
undetectable		 3ko0G-1ag9A:
22.70
3ko0H-1ag9A:
22.70
3ko0I-1ag9A:
22.70
3ko0J-1ag9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czk FLAVODOXIN

(Synechococcus
elongatus) 		PF00258
(Flavodoxin_1) 		5 ASP A 144
LEU A 141
PHE A  86
ILE A  17
SER A 130
 None
 1.16A 3ko0G-1czkA:
undetectable
3ko0H-1czkA:
undetectable
3ko0I-1czkA:
undetectable
3ko0J-1czkA:
undetectable		 3ko0G-1czkA:
21.02
3ko0H-1czkA:
21.02
3ko0I-1czkA:
21.02
3ko0J-1czkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		5 GLU A 343
LEU A 339
SER A 340
PHE A 344
ASP A 252
 None
 1.08A 3ko0G-1ij5A:
6.8
3ko0H-1ij5A:
7.2
3ko0I-1ij5A:
6.8
3ko0J-1ij5A:
6.9		 3ko0G-1ij5A:
17.12
3ko0H-1ij5A:
17.12
3ko0I-1ij5A:
17.12
3ko0J-1ij5A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ASP A 319
LEU A 314
ILE A  83
PHE A 323
SER A 184
 None
 1.31A 3ko0G-1imvA:
undetectable
3ko0H-1imvA:
undetectable
3ko0I-1imvA:
undetectable
3ko0J-1imvA:
undetectable		 3ko0G-1imvA:
13.28
3ko0H-1imvA:
13.28
3ko0I-1imvA:
13.28
3ko0J-1imvA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ASP B 731
LEU B 499
SER B 446
PHE B 500
SER B 315
 None
 1.47A 3ko0G-1m2vB:
0.0
3ko0H-1m2vB:
undetectable
3ko0I-1m2vB:
1.3
3ko0J-1m2vB:
0.0		 3ko0G-1m2vB:
7.34
3ko0H-1m2vB:
7.34
3ko0I-1m2vB:
7.34
3ko0J-1m2vB:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 ASP A 439
LEU A 436
SER A 486
ILE A 423
ASP A 482
 None
 1.10A 3ko0G-1pz3A:
undetectable
3ko0H-1pz3A:
undetectable
3ko0I-1pz3A:
undetectable
3ko0J-1pz3A:
undetectable		 3ko0G-1pz3A:
12.17
3ko0H-1pz3A:
12.17
3ko0I-1pz3A:
12.17
3ko0J-1pz3A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ILE A  42
CYH A   1
PHE A  64
PHE A  70
SER A  82
 None
 1.37A 3ko0G-1towA:
0.0
3ko0H-1towA:
undetectable
3ko0I-1towA:
0.0
3ko0J-1towA:
0.0		 3ko0G-1towA:
18.18
3ko0H-1towA:
18.18
3ko0I-1towA:
18.18
3ko0J-1towA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 GLU A 117
ASP A 116
SER A 161
ILE A 119
PHE A 198
 None
 1.38A 3ko0G-1u08A:
undetectable
3ko0H-1u08A:
undetectable
3ko0I-1u08A:
0.0
3ko0J-1u08A:
0.0		 3ko0G-1u08A:
13.17
3ko0H-1u08A:
13.17
3ko0I-1u08A:
13.17
3ko0J-1u08A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v38 SAM-DOMAIN PROTEIN
SAMSN-1

(Mus musculus) 		PF07647
(SAM_2) 		5 GLU A  37
ASP A  40
LEU A  32
ILE A  15
SER A   6
 None
 1.45A 3ko0G-1v38A:
undetectable
3ko0H-1v38A:
undetectable
3ko0I-1v38A:
undetectable
3ko0J-1v38A:
undetectable		 3ko0G-1v38A:
20.37
3ko0H-1v38A:
20.37
3ko0I-1v38A:
20.37
3ko0J-1v38A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vaz NSFL1 COFACTOR P47

(Rattus
norvegicus) 		PF08059
(SEP) 		5 ASP A  64
LEU A  16
SER A  22
PHE A  21
ILE A  43
 None
 1.46A 3ko0G-1vazA:
undetectable
3ko0H-1vazA:
undetectable
3ko0I-1vazA:
undetectable
3ko0J-1vazA:
undetectable		 3ko0G-1vazA:
23.15
3ko0H-1vazA:
23.15
3ko0I-1vazA:
23.15
3ko0J-1vazA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 ASP A 121
LEU A 129
ILE A  82
PHE A 140
SER A 135
 None
 1.32A 3ko0G-1ybiA:
undetectable
3ko0H-1ybiA:
undetectable
3ko0I-1ybiA:
undetectable
3ko0J-1ybiA:
undetectable		 3ko0G-1ybiA:
14.58
3ko0H-1ybiA:
14.58
3ko0I-1ybiA:
14.58
3ko0J-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLU A 181
LEU A 177
SER A 178
PHE A 182
ILE A 185
 None
 1.19A 3ko0G-1ykwA:
undetectable
3ko0H-1ykwA:
undetectable
3ko0I-1ykwA:
undetectable
3ko0J-1ykwA:
undetectable		 3ko0G-1ykwA:
12.47
3ko0H-1ykwA:
12.47
3ko0I-1ykwA:
12.47
3ko0J-1ykwA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 ASP A  13
LEU A  25
SER A  24
ILE A  36
CYH A  10
 None
 1.18A 3ko0G-1zzmA:
0.0
3ko0H-1zzmA:
undetectable
3ko0I-1zzmA:
0.0
3ko0J-1zzmA:
0.0		 3ko0G-1zzmA:
14.89
3ko0H-1zzmA:
14.89
3ko0I-1zzmA:
14.89
3ko0J-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ASP A 329
LEU A 313
ILE A 311
PHE A 364
PHE A 371
 None
 1.23A 3ko0G-2bucA:
undetectable
3ko0H-2bucA:
undetectable
3ko0I-2bucA:
undetectable
3ko0J-2bucA:
undetectable		 3ko0G-2bucA:
7.57
3ko0H-2bucA:
7.57
3ko0I-2bucA:
7.57
3ko0J-2bucA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		5 ASP A 375
SER A 339
ILE A 381
PHE A 326
PHE A 253
 None
 1.32A 3ko0G-2d1gA:
undetectable
3ko0H-2d1gA:
undetectable
3ko0I-2d1gA:
undetectable
3ko0J-2d1gA:
undetectable		 3ko0G-2d1gA:
11.51
3ko0H-2d1gA:
11.51
3ko0I-2d1gA:
11.51
3ko0J-2d1gA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg2 APOLIPOPROTEIN A-I
BINDING PROTEIN

(Mus musculus) 		PF03853
(YjeF_N) 		5 LEU A 207
SER A 186
ILE A  65
CYH A  97
SER A 191
 None
 1.33A 3ko0G-2dg2A:
undetectable
3ko0H-2dg2A:
undetectable
3ko0I-2dg2A:
undetectable
3ko0J-2dg2A:
undetectable		 3ko0G-2dg2A:
15.35
3ko0H-2dg2A:
15.35
3ko0I-2dg2A:
15.35
3ko0J-2dg2A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		5 GLU A 140
LEU A  18
ILE A 141
PHE A 135
PHE A 194
 None
None
None
HMH  A 301 ( 4.9A)
None
 1.46A 3ko0G-2gm8A:
1.3
3ko0H-2gm8A:
1.3
3ko0I-2gm8A:
1.3
3ko0J-2gm8A:
1.3		 3ko0G-2gm8A:
20.23
3ko0H-2gm8A:
20.23
3ko0I-2gm8A:
20.23
3ko0J-2gm8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		5 LEU A 186
SER A 185
ILE A   3
PHE A  38
SER A 162
 None
 1.36A 3ko0G-2nuxA:
undetectable
3ko0H-2nuxA:
undetectable
3ko0I-2nuxA:
undetectable
3ko0J-2nuxA:
undetectable		 3ko0G-2nuxA:
16.38
3ko0H-2nuxA:
16.38
3ko0I-2nuxA:
16.38
3ko0J-2nuxA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 ASP A 154
LEU A  92
ILE A 104
ASP A 170
SER A 232
 None
None
None
FE  A 501 ( 2.3A)
FE  A 501 ( 3.8A)
 1.31A 3ko0G-2ohhA:
undetectable
3ko0H-2ohhA:
undetectable
3ko0I-2ohhA:
undetectable
3ko0J-2ohhA:
undetectable		 3ko0G-2ohhA:
13.40
3ko0H-2ohhA:
13.40
3ko0I-2ohhA:
13.40
3ko0J-2ohhA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN

(Plasmodium
yoelii) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 212
PHE A 206
ILE A  88
PHE A  94
SER A 223
 None
 1.39A 3ko0G-2p1iA:
undetectable
3ko0H-2p1iA:
undetectable
3ko0I-2p1iA:
undetectable
3ko0J-2p1iA:
undetectable		 3ko0G-2p1iA:
15.88
3ko0H-2p1iA:
15.88
3ko0I-2p1iA:
15.88
3ko0J-2p1iA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prr ALKYLHYDROPEROXIDASE
AHPD CORE:
UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF02627
(CMD) 		5 LEU A  42
ILE A  27
PHE A  55
PHE A  54
SER A 171
 None
None
None
None
PEG  A 199 (-2.9A)
 1.02A 3ko0G-2prrA:
1.6
3ko0H-2prrA:
1.8
3ko0I-2prrA:
1.8
3ko0J-2prrA:
1.8		 3ko0G-2prrA:
20.90
3ko0H-2prrA:
20.90
3ko0I-2prrA:
20.90
3ko0J-2prrA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvu ARTJ

(Geobacillus
stearothermophilus) 		PF00497
(SBP_bac_3) 		5 ASP A  81
LEU A  71
SER A  74
PHE A  72
ILE A 208
 None
 1.31A 3ko0G-2pvuA:
0.0
3ko0H-2pvuA:
undetectable
3ko0I-2pvuA:
undetectable
3ko0J-2pvuA:
undetectable		 3ko0G-2pvuA:
16.61
3ko0H-2pvuA:
16.61
3ko0I-2pvuA:
16.61
3ko0J-2pvuA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron) 		PF00294
(PfkB) 		5 GLU A 180
ASP A 178
LEU A 154
ILE A 184
PHE A 223
 None
 1.38A 3ko0G-2qhpA:
undetectable
3ko0H-2qhpA:
undetectable
3ko0I-2qhpA:
undetectable
3ko0J-2qhpA:
undetectable		 3ko0G-2qhpA:
16.61
3ko0H-2qhpA:
16.61
3ko0I-2qhpA:
16.61
3ko0J-2qhpA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qoj INTRON-ENCODED DNA
ENDONUCLEASE I-ANII

(Aspergillus
nidulans) 		PF00961
(LAGLIDADG_1) 		5 LEU Z 216
PHE Z 215
ILE Z 145
PHE Z 187
SER Z 205
 None
 1.41A 3ko0G-2qojZ:
undetectable
3ko0H-2qojZ:
undetectable
3ko0I-2qojZ:
undetectable
3ko0J-2qojZ:
undetectable		 3ko0G-2qojZ:
17.93
3ko0H-2qojZ:
17.93
3ko0I-2qojZ:
17.93
3ko0J-2qojZ:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsd UNCHARACTERIZED
CONSERVED PROTEIN

(Idiomarina
loihiensis) 		PF07566
(DUF1543) 		5 ASP A  26
LEU A  55
SER A  57
PHE A  58
ASP A 103
 None
 1.42A 3ko0G-2qsdA:
undetectable
3ko0H-2qsdA:
undetectable
3ko0I-2qsdA:
undetectable
3ko0J-2qsdA:
undetectable		 3ko0G-2qsdA:
22.10
3ko0H-2qsdA:
22.10
3ko0I-2qsdA:
22.10
3ko0J-2qsdA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 ASP A 748
LEU A 738
ILE A 769
PHE A 705
PHE A 751
 None
 1.20A 3ko0G-2v26A:
0.9
3ko0H-2v26A:
undetectable
3ko0I-2v26A:
1.5
3ko0J-2v26A:
1.4		 3ko0G-2v26A:
9.24
3ko0H-2v26A:
9.24
3ko0I-2v26A:
9.24
3ko0J-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 SER A 274
ILE A 343
CYH A 258
PHE A 361
SER A 369
 UDP  A1477 ( 3.7A)
None
None
None
UDP  A1477 (-2.6A)
 1.45A 3ko0G-2vg8A:
0.0
3ko0H-2vg8A:
undetectable
3ko0I-2vg8A:
0.0
3ko0J-2vg8A:
0.0		 3ko0G-2vg8A:
12.24
3ko0H-2vg8A:
12.24
3ko0I-2vg8A:
12.24
3ko0J-2vg8A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 ASP A 402
LEU A 363
ILE A 398
PHE A 107
ASP A 141
 None
 1.17A 3ko0G-2wn4A:
undetectable
3ko0H-2wn4A:
undetectable
3ko0I-2wn4A:
undetectable
3ko0J-2wn4A:
undetectable		 3ko0G-2wn4A:
13.10
3ko0H-2wn4A:
13.10
3ko0I-2wn4A:
13.10
3ko0J-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		5 GLU A 167
ASP A 148
LEU A 163
SER A 166
PHE A  73
 None
 1.24A 3ko0G-2xdfA:
0.0
3ko0H-2xdfA:
undetectable
3ko0I-2xdfA:
0.0
3ko0J-2xdfA:
0.0		 3ko0G-2xdfA:
12.15
3ko0H-2xdfA:
12.15
3ko0I-2xdfA:
12.15
3ko0J-2xdfA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 ASP A 763
LEU A 815
ILE A 757
PHE A 724
ASP A 556
 None
 0.95A 3ko0G-2zaiA:
undetectable
3ko0H-2zaiA:
undetectable
3ko0I-2zaiA:
undetectable
3ko0J-2zaiA:
undetectable		 3ko0G-2zaiA:
10.47
3ko0H-2zaiA:
10.47
3ko0I-2zaiA:
10.47
3ko0J-2zaiA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus) 		PF00150
(Cellulase) 		5 LEU A 107
PHE A 149
ILE A 136
PHE A 182
SER A 227
 None
 1.29A 3ko0G-3ayrA:
undetectable
3ko0H-3ayrA:
undetectable
3ko0I-3ayrA:
undetectable
3ko0J-3ayrA:
undetectable		 3ko0G-3ayrA:
14.80
3ko0H-3ayrA:
14.80
3ko0I-3ayrA:
14.80
3ko0J-3ayrA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 PHE X 100
ILE X  88
PHE X 259
ASP X  18
SER X  11
 None
 1.30A 3ko0G-3e13X:
0.0
3ko0H-3e13X:
undetectable
3ko0I-3e13X:
undetectable
3ko0J-3e13X:
undetectable		 3ko0G-3e13X:
16.67
3ko0H-3e13X:
16.67
3ko0I-3e13X:
16.67
3ko0J-3e13X:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 SER X 239
ILE X 278
PHE X 259
ASP X  18
SER X  11
 None
 1.23A 3ko0G-3e13X:
0.0
3ko0H-3e13X:
undetectable
3ko0I-3e13X:
undetectable
3ko0J-3e13X:
undetectable		 3ko0G-3e13X:
16.67
3ko0H-3e13X:
16.67
3ko0I-3e13X:
16.67
3ko0J-3e13X:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 SER A 171
PHE A 410
ILE A 395
PHE A 298
ASP A 164
 None
 1.16A 3ko0G-3eafA:
undetectable
3ko0H-3eafA:
undetectable
3ko0I-3eafA:
undetectable
3ko0J-3eafA:
undetectable		 3ko0G-3eafA:
12.92
3ko0H-3eafA:
12.92
3ko0I-3eafA:
12.92
3ko0J-3eafA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		5 ASP A 229
LEU A 289
SER A 285
PHE A 288
ILE A 251
 FE  A 334 (-3.1A)
None
None
None
None
 1.21A 3ko0G-3ktcA:
undetectable
3ko0H-3ktcA:
undetectable
3ko0I-3ktcA:
undetectable
3ko0J-3ktcA:
undetectable		 3ko0G-3ktcA:
16.22
3ko0H-3ktcA:
16.22
3ko0I-3ktcA:
16.22
3ko0J-3ktcA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb6 INTERLEUKIN-13

(Homo sapiens) 		PF03487
(IL13) 		5 GLU A  49
LEU A  83
SER A  82
ILE A  37
PHE A  70
 None
 1.42A 3ko0G-3lb6A:
undetectable
3ko0H-3lb6A:
undetectable
3ko0I-3lb6A:
undetectable
3ko0J-3lb6A:
undetectable		 3ko0G-3lb6A:
21.58
3ko0H-3lb6A:
21.58
3ko0I-3lb6A:
21.58
3ko0J-3lb6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		5 ASP A 205
LEU A 212
SER A 213
PHE A 211
ILE A 208
 None
None
None
None
DTD  A 248 ( 4.1A)
 1.29A 3ko0G-3oqvA:
undetectable
3ko0H-3oqvA:
undetectable
3ko0I-3oqvA:
undetectable
3ko0J-3oqvA:
undetectable		 3ko0G-3oqvA:
15.73
3ko0H-3oqvA:
15.73
3ko0I-3oqvA:
15.73
3ko0J-3oqvA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 LEU A 185
SER A 116
PHE A 115
ILE A 108
PHE A  22
 None
 1.18A 3ko0G-3qanA:
undetectable
3ko0H-3qanA:
undetectable
3ko0I-3qanA:
undetectable
3ko0J-3qanA:
undetectable		 3ko0G-3qanA:
12.48
3ko0H-3qanA:
12.48
3ko0I-3qanA:
12.48
3ko0J-3qanA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 ASP A 344
LEU A 332
PHE A 331
ILE A 314
PHE A 293
 None
 1.39A 3ko0G-3rreA:
undetectable
3ko0H-3rreA:
undetectable
3ko0I-3rreA:
undetectable
3ko0J-3rreA:
undetectable		 3ko0G-3rreA:
11.38
3ko0H-3rreA:
11.38
3ko0I-3rreA:
11.38
3ko0J-3rreA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 LEU A 242
SER A 188
ILE A 236
PHE A 291
SER A 260
 None
 1.42A 3ko0G-3upyA:
undetectable
3ko0H-3upyA:
undetectable
3ko0I-3upyA:
undetectable
3ko0J-3upyA:
undetectable		 3ko0G-3upyA:
12.68
3ko0H-3upyA:
12.68
3ko0I-3upyA:
12.68
3ko0J-3upyA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 SER A 188
ILE A 236
CYH A 172
PHE A 291
SER A 260
 None
 1.37A 3ko0G-3upyA:
undetectable
3ko0H-3upyA:
undetectable
3ko0I-3upyA:
undetectable
3ko0J-3upyA:
undetectable		 3ko0G-3upyA:
12.68
3ko0H-3upyA:
12.68
3ko0I-3upyA:
12.68
3ko0J-3upyA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu1 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0242

(Pyrococcus
horikoshii) 		no annotation 5 ASP A 769
LEU A 821
ILE A 763
PHE A 730
ASP A 558
 None
 1.00A 3ko0G-3vu1A:
undetectable
3ko0H-3vu1A:
undetectable
3ko0I-3vu1A:
undetectable
3ko0J-3vu1A:
undetectable		 3ko0G-3vu1A:
11.06
3ko0H-3vu1A:
11.06
3ko0I-3vu1A:
11.06
3ko0J-3vu1A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 LEU A 334
PHE A 333
ILE A 236
PHE A 264
ASP A 325
 None
 1.14A 3ko0G-3wnpA:
undetectable
3ko0H-3wnpA:
undetectable
3ko0I-3wnpA:
undetectable
3ko0J-3wnpA:
undetectable		 3ko0G-3wnpA:
9.04
3ko0H-3wnpA:
9.04
3ko0I-3wnpA:
9.04
3ko0J-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wov OLIGOSACCHARYL
TRANSFERASE

(Pyrococcus
abyssi) 		no annotation 5 ASP A 771
LEU A 821
ILE A 765
PHE A 732
ASP A 559
 None
 0.98A 3ko0G-3wovA:
undetectable
3ko0H-3wovA:
undetectable
3ko0I-3wovA:
undetectable
3ko0J-3wovA:
undetectable		 3ko0G-3wovA:
9.96
3ko0H-3wovA:
9.96
3ko0I-3wovA:
9.96
3ko0J-3wovA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wry TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		5 LEU A 107
ILE A  14
PHE A 167
ASP A 163
SER A 162
 None
 1.37A 3ko0G-3wryA:
undetectable
3ko0H-3wryA:
undetectable
3ko0I-3wryA:
undetectable
3ko0J-3wryA:
undetectable		 3ko0G-3wryA:
12.53
3ko0H-3wryA:
12.53
3ko0I-3wryA:
12.53
3ko0J-3wryA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 GLU A 747
LEU A 232
ILE A 107
PHE A  99
PHE A 240
 None
None
None
DMU  A1776 (-4.5A)
None
 1.39A 3ko0G-4a01A:
undetectable
3ko0H-4a01A:
1.2
3ko0I-4a01A:
1.8
3ko0J-4a01A:
1.7		 3ko0G-4a01A:
8.76
3ko0H-4a01A:
8.76
3ko0I-4a01A:
8.76
3ko0J-4a01A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 ASP A 748
LEU A 738
ILE A 769
PHE A 705
PHE A 751
 None
 1.28A 3ko0G-4anjA:
undetectable
3ko0H-4anjA:
undetectable
3ko0I-4anjA:
undetectable
3ko0J-4anjA:
undetectable		 3ko0G-4anjA:
6.93
3ko0H-4anjA:
6.93
3ko0I-4anjA:
6.93
3ko0J-4anjA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 LEU A  99
SER A  62
ILE A  73
ASP A 363
SER A 361
 None
 1.41A 3ko0G-4ay1A:
undetectable
3ko0H-4ay1A:
undetectable
3ko0I-4ay1A:
undetectable
3ko0J-4ay1A:
undetectable		 3ko0G-4ay1A:
13.70
3ko0H-4ay1A:
13.70
3ko0I-4ay1A:
13.70
3ko0J-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ASP A  14
LEU A  72
ILE A  75
PHE A  39
SER A  63
 None
 1.38A 3ko0G-4bc5A:
undetectable
3ko0H-4bc5A:
undetectable
3ko0I-4bc5A:
undetectable
3ko0J-4bc5A:
undetectable		 3ko0G-4bc5A:
11.78
3ko0H-4bc5A:
11.78
3ko0I-4bc5A:
11.78
3ko0J-4bc5A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 ASP A 318
LEU A 332
PHE A 327
ILE A 325
ASP A 351
 None
 1.29A 3ko0G-4bhdA:
undetectable
3ko0H-4bhdA:
undetectable
3ko0I-4bhdA:
undetectable
3ko0J-4bhdA:
undetectable		 3ko0G-4bhdA:
12.38
3ko0H-4bhdA:
12.38
3ko0I-4bhdA:
12.38
3ko0J-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN

(Burkholderia
pseudomallei) 		no annotation 5 ASP A 179
LEU A  19
ILE A 210
ASP A 173
SER A  79
 None
 1.44A 3ko0G-4bqnA:
undetectable
3ko0H-4bqnA:
undetectable
3ko0I-4bqnA:
undetectable
3ko0J-4bqnA:
undetectable		 3ko0G-4bqnA:
17.38
3ko0H-4bqnA:
17.38
3ko0I-4bqnA:
17.38
3ko0J-4bqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 GLU A 221
LEU A 217
SER A 218
PHE A 222
ILE A 225
 None
 1.14A 3ko0G-4chlA:
undetectable
3ko0H-4chlA:
undetectable
3ko0I-4chlA:
undetectable
3ko0J-4chlA:
undetectable		 3ko0G-4chlA:
16.32
3ko0H-4chlA:
16.32
3ko0I-4chlA:
16.32
3ko0J-4chlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkb DEOXYURIDINE
TRIPHOSPHATASE

(Trypanosoma
brucei) 		PF08761
(dUTPase_2) 		5 ASP A 163
LEU A  70
ILE A 197
PHE A 158
PHE A 171
 None
 1.35A 3ko0G-4dkbA:
undetectable
3ko0H-4dkbA:
undetectable
3ko0I-4dkbA:
undetectable
3ko0J-4dkbA:
undetectable		 3ko0G-4dkbA:
14.73
3ko0H-4dkbA:
14.73
3ko0I-4dkbA:
14.73
3ko0J-4dkbA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dth VGRG PROTEIN

(Vibrio cholerae) 		PF16671
(ACD) 		5 ASP A  87
LEU A 347
SER A 349
ILE A  13
CYH A  84
 None
 1.40A 3ko0G-4dthA:
undetectable
3ko0H-4dthA:
undetectable
3ko0I-4dthA:
undetectable
3ko0J-4dthA:
undetectable		 3ko0G-4dthA:
13.44
3ko0H-4dthA:
13.44
3ko0I-4dthA:
13.44
3ko0J-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 5 ASP A 676
LEU A 727
SER A 729
PHE A 426
ASP A 421
 None
 1.28A 3ko0G-4ecoA:
undetectable
3ko0H-4ecoA:
undetectable
3ko0I-4ecoA:
undetectable
3ko0J-4ecoA:
undetectable		 3ko0G-4ecoA:
11.07
3ko0H-4ecoA:
11.07
3ko0I-4ecoA:
11.07
3ko0J-4ecoA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 GLU A 214
LEU A 228
SER A 231
ILE A 288
PHE A 252
 None
 1.28A 3ko0G-4fidA:
undetectable
3ko0H-4fidA:
undetectable
3ko0I-4fidA:
undetectable
3ko0J-4fidA:
undetectable		 3ko0G-4fidA:
15.16
3ko0H-4fidA:
15.16
3ko0I-4fidA:
15.16
3ko0J-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 GLU A 214
LEU A 228
SER A 231
PHE A 252
PHE A 208
 None
 1.20A 3ko0G-4fidA:
undetectable
3ko0H-4fidA:
undetectable
3ko0I-4fidA:
undetectable
3ko0J-4fidA:
undetectable		 3ko0G-4fidA:
15.16
3ko0H-4fidA:
15.16
3ko0I-4fidA:
15.16
3ko0J-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.24A 3ko0G-4hwtA:
0.8
3ko0H-4hwtA:
1.0
3ko0I-4hwtA:
1.1
3ko0J-4hwtA:
1.1		 3ko0G-4hwtA:
14.49
3ko0H-4hwtA:
14.49
3ko0I-4hwtA:
14.49
3ko0J-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		5 GLU A  68
ASP A  67
LEU A 109
SER A 110
ILE A  72
 None
 1.44A 3ko0G-4ihqA:
undetectable
3ko0H-4ihqA:
undetectable
3ko0I-4ihqA:
undetectable
3ko0J-4ihqA:
undetectable		 3ko0G-4ihqA:
11.98
3ko0H-4ihqA:
11.98
3ko0I-4ihqA:
11.98
3ko0J-4ihqA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		5 ASP A 270
LEU A  44
SER A  46
ILE A   8
ASP A 291
 None
 1.34A 3ko0G-4k37A:
undetectable
3ko0H-4k37A:
undetectable
3ko0I-4k37A:
undetectable
3ko0J-4k37A:
undetectable		 3ko0G-4k37A:
15.14
3ko0H-4k37A:
15.14
3ko0I-4k37A:
15.14
3ko0J-4k37A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 GLU A 336
ASP A 419
LEU A 355
PHE A 451
SER A 383
 None
 1.41A 3ko0G-4ktpA:
undetectable
3ko0H-4ktpA:
undetectable
3ko0I-4ktpA:
undetectable
3ko0J-4ktpA:
undetectable		 3ko0G-4ktpA:
7.74
3ko0H-4ktpA:
7.74
3ko0I-4ktpA:
7.74
3ko0J-4ktpA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A  97
LEU A 289
PHE A 331
ILE A 295
ASP A 357
 None
 1.24A 3ko0G-4kwsA:
undetectable
3ko0H-4kwsA:
undetectable
3ko0I-4kwsA:
undetectable
3ko0J-4kwsA:
undetectable		 3ko0G-4kwsA:
13.82
3ko0H-4kwsA:
13.82
3ko0I-4kwsA:
13.82
3ko0J-4kwsA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnd CTP
L-MYO-INOSITOL-1-PHO
SPHATE
CYTIDYLYLTRANSFERASE
/CDP-L-MYO-INOSITOL
MYO-INOSITOLPHOSPHOT
RANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf)
PF12804
(NTP_transf_3) 		5 GLU A 362
SER A 308
ILE A 363
ASP A 296
SER A 300
 None
 1.35A 3ko0G-4mndA:
undetectable
3ko0H-4mndA:
undetectable
3ko0I-4mndA:
undetectable
3ko0J-4mndA:
undetectable		 3ko0G-4mndA:
12.84
3ko0H-4mndA:
12.84
3ko0I-4mndA:
12.84
3ko0J-4mndA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 LEU B  82
SER B 151
ILE B  74
PHE B 187
ASP B 160
 None
ACT  B 302 (-2.6A)
None
None
ZN  B 301 (-2.5A)
 1.47A 3ko0G-4nt9B:
undetectable
3ko0H-4nt9B:
undetectable
3ko0I-4nt9B:
undetectable
3ko0J-4nt9B:
undetectable		 3ko0G-4nt9B:
16.82
3ko0H-4nt9B:
16.82
3ko0I-4nt9B:
16.82
3ko0J-4nt9B:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 LEU A 227
SER A 226
PHE A 238
ILE A 273
SER A 189
 None
 1.24A 3ko0G-4ojzA:
undetectable
3ko0H-4ojzA:
undetectable
3ko0I-4ojzA:
undetectable
3ko0J-4ojzA:
undetectable		 3ko0G-4ojzA:
8.97
3ko0H-4ojzA:
8.97
3ko0I-4ojzA:
8.97
3ko0J-4ojzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouj HEMAGGLUTININ
COMPONENT HA33

(Clostridium
botulinum) 		PF14200
(RicinB_lectin_2) 		5 ASP A 123
LEU A 131
ILE A  84
PHE A 142
SER A 137
 None
 1.41A 3ko0G-4oujA:
undetectable
3ko0H-4oujA:
undetectable
3ko0I-4oujA:
undetectable
3ko0J-4oujA:
undetectable		 3ko0G-4oujA:
15.31
3ko0H-4oujA:
15.31
3ko0I-4oujA:
15.31
3ko0J-4oujA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 5 LEU A  72
PHE A  34
ILE A  27
PHE A  21
PHE A  78
 None
 1.39A 3ko0G-4p5wA:
4.5
3ko0H-4p5wA:
4.3
3ko0I-4p5wA:
5.4
3ko0J-4p5wA:
5.3		 3ko0G-4p5wA:
13.79
3ko0H-4p5wA:
13.79
3ko0I-4p5wA:
13.79
3ko0J-4p5wA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 GLU A 132
LEU A  70
SER A  67
ILE A 292
PHE A  65
 UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
UNX  A 408 ( 4.8A)
 1.21A 3ko0G-4pwyA:
undetectable
3ko0H-4pwyA:
undetectable
3ko0I-4pwyA:
undetectable
3ko0J-4pwyA:
undetectable		 3ko0G-4pwyA:
18.85
3ko0H-4pwyA:
18.85
3ko0I-4pwyA:
18.85
3ko0J-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		5 ASP A 205
LEU A 254
SER A 252
PHE A 209
PHE A 119
 None
 1.42A 3ko0G-4qdgA:
undetectable
3ko0H-4qdgA:
undetectable
3ko0I-4qdgA:
undetectable
3ko0J-4qdgA:
undetectable		 3ko0G-4qdgA:
17.32
3ko0H-4qdgA:
17.32
3ko0I-4qdgA:
17.32
3ko0J-4qdgA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qla JUVENILE HORMONE
EPOXIDE HYDROLASE

(Bombyx mori) 		PF06441
(EHN) 		5 LEU A 386
SER A 234
ILE A 389
PHE A 247
SER A 249
 None
 1.39A 3ko0G-4qlaA:
undetectable
3ko0H-4qlaA:
undetectable
3ko0I-4qlaA:
undetectable
3ko0J-4qlaA:
undetectable		 3ko0G-4qlaA:
12.02
3ko0H-4qlaA:
12.02
3ko0I-4qlaA:
12.02
3ko0J-4qlaA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcm METHYLATED
RNA-BINDING PROTEIN
1

(Saccharomyces
cerevisiae) 		PF04146
(YTH) 		5 LEU A 289
ILE A 251
PHE A 204
PHE A 203
PHE A 157
 None
 1.37A 3ko0G-4rcmA:
undetectable
3ko0H-4rcmA:
undetectable
3ko0I-4rcmA:
undetectable
3ko0J-4rcmA:
undetectable		 3ko0G-4rcmA:
22.02
3ko0H-4rcmA:
22.02
3ko0I-4rcmA:
22.02
3ko0J-4rcmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 GLU A2530
LEU A2506
ILE A2526
PHE A2572
ASP A2537
 None
 1.40A 3ko0G-4rh7A:
undetectable
3ko0H-4rh7A:
undetectable
3ko0I-4rh7A:
undetectable
3ko0J-4rh7A:
undetectable		 3ko0G-4rh7A:
2.91
3ko0H-4rh7A:
2.91
3ko0I-4rh7A:
2.91
3ko0J-4rh7A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 SER A 368
ILE A 413
PHE A 420
ASP A 346
SER A 363
 None
 1.21A 3ko0G-4u3tA:
undetectable
3ko0H-4u3tA:
undetectable
3ko0I-4u3tA:
undetectable
3ko0J-4u3tA:
undetectable		 3ko0G-4u3tA:
15.76
3ko0H-4u3tA:
15.76
3ko0I-4u3tA:
15.76
3ko0J-4u3tA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		5 GLU A 261
ASP A 473
LEU A 262
SER A 258
ASP A 467
 None
 1.47A 3ko0G-4upiA:
undetectable
3ko0H-4upiA:
undetectable
3ko0I-4upiA:
undetectable
3ko0J-4upiA:
undetectable		 3ko0G-4upiA:
10.66
3ko0H-4upiA:
10.66
3ko0I-4upiA:
10.66
3ko0J-4upiA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		5 GLU A 356
ASP A 281
PHE A 355
ILE A 360
ASP A 169
 None
None
EDO  A 403 ( 4.8A)
None
None
 1.27A 3ko0G-4wzzA:
undetectable
3ko0H-4wzzA:
undetectable
3ko0I-4wzzA:
undetectable
3ko0J-4wzzA:
undetectable		 3ko0G-4wzzA:
13.01
3ko0H-4wzzA:
13.01
3ko0I-4wzzA:
13.01
3ko0J-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		no annotation 5 ASP A 593
LEU A 634
ILE A 551
PHE A 590
PHE A 623
 None
 1.27A 3ko0G-4yomA:
undetectable
3ko0H-4yomA:
undetectable
3ko0I-4yomA:
undetectable
3ko0J-4yomA:
undetectable		 3ko0G-4yomA:
18.44
3ko0H-4yomA:
18.44
3ko0I-4yomA:
18.44
3ko0J-4yomA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 GLU A 724
LEU A 735
ILE A  21
PHE A 115
ASP A 593
 None
 1.25A 3ko0G-5ah5A:
undetectable
3ko0H-5ah5A:
undetectable
3ko0I-5ah5A:
undetectable
3ko0J-5ah5A:
undetectable		 3ko0G-5ah5A:
7.86
3ko0H-5ah5A:
7.86
3ko0I-5ah5A:
7.86
3ko0J-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 ASP A 661
LEU A 713
ILE A 655
PHE A 622
ASP A 454
 None
 0.93A 3ko0G-5azaA:
undetectable
3ko0H-5azaA:
undetectable
3ko0I-5azaA:
undetectable
3ko0J-5azaA:
undetectable		 3ko0G-5azaA:
8.49
3ko0H-5azaA:
8.49
3ko0I-5azaA:
8.49
3ko0J-5azaA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE
ORNITHINE
DECARBOXYLASE
ANTIZYME 1

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02100
(ODC_AZ)
PF02784
(Orn_Arg_deC_N) 		5 SER B 191
PHE B 195
ILE B 174
PHE B 192
ASP A 332
 None
None
None
PLP  A 600 ( 4.4A)
None
 1.42A 3ko0G-5bwaB:
undetectable
3ko0H-5bwaB:
undetectable
3ko0I-5bwaB:
undetectable
3ko0J-5bwaB:
undetectable		 3ko0G-5bwaB:
21.47
3ko0H-5bwaB:
21.47
3ko0I-5bwaB:
21.47
3ko0J-5bwaB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 GLU A  23
LEU A  26
ILE A  61
ASP A 417
SER A 403
 None
 1.29A 3ko0G-5cykA:
undetectable
3ko0H-5cykA:
undetectable
3ko0I-5cykA:
undetectable
3ko0J-5cykA:
undetectable		 3ko0G-5cykA:
10.91
3ko0H-5cykA:
10.91
3ko0I-5cykA:
10.91
3ko0J-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		5 ASP A 303
ILE A 128
PHE A 298
ASP A 269
SER A 360
 GAL  A 501 (-2.8A)
None
None
None
None
 0.96A 3ko0G-5dvjA:
undetectable
3ko0H-5dvjA:
undetectable
3ko0I-5dvjA:
undetectable
3ko0J-5dvjA:
undetectable		 3ko0G-5dvjA:
11.48
3ko0H-5dvjA:
11.48
3ko0I-5dvjA:
11.48
3ko0J-5dvjA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 LEU A  94
SER A  95
PHE A  69
ILE A  74
SER A 164
 None
 1.13A 3ko0G-5hyhA:
undetectable
3ko0H-5hyhA:
undetectable
3ko0I-5hyhA:
undetectable
3ko0J-5hyhA:
undetectable		 3ko0G-5hyhA:
14.19
3ko0H-5hyhA:
14.19
3ko0I-5hyhA:
14.19
3ko0J-5hyhA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 SER A  95
PHE A  69
ILE A  74
PHE A 166
SER A 164
 None
 1.21A 3ko0G-5hyhA:
undetectable
3ko0H-5hyhA:
undetectable
3ko0I-5hyhA:
undetectable
3ko0J-5hyhA:
undetectable		 3ko0G-5hyhA:
14.19
3ko0H-5hyhA:
14.19
3ko0I-5hyhA:
14.19
3ko0J-5hyhA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 ASP B 376
LEU B 361
SER B 386
CYH B 381
ASP B 397
 None
 1.25A 3ko0G-5hzgB:
undetectable
3ko0H-5hzgB:
undetectable
3ko0I-5hzgB:
undetectable
3ko0J-5hzgB:
undetectable		 3ko0G-5hzgB:
8.73
3ko0H-5hzgB:
8.73
3ko0I-5hzgB:
8.73
3ko0J-5hzgB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		5 LEU A 148
SER A 149
PHE A 153
ILE A 156
PHE A  80
 None
 1.40A 3ko0G-5i2qA:
7.0
3ko0H-5i2qA:
7.3
3ko0I-5i2qA:
7.2
3ko0J-5i2qA:
7.3		 3ko0G-5i2qA:
25.55
3ko0H-5i2qA:
25.55
3ko0I-5i2qA:
25.55
3ko0J-5i2qA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 GLU A 350
ASP A 351
LEU A 484
SER A 483
PHE A 487
 None
 1.12A 3ko0G-5iudA:
undetectable
3ko0H-5iudA:
undetectable
3ko0I-5iudA:
undetectable
3ko0J-5iudA:
undetectable		 3ko0G-5iudA:
7.87
3ko0H-5iudA:
7.87
3ko0I-5iudA:
7.87
3ko0J-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		5 GLU A  94
SER A  90
ILE A  97
CYH A 108
PHE A 112
 None
 1.33A 3ko0G-5k04A:
undetectable
3ko0H-5k04A:
undetectable
3ko0I-5k04A:
undetectable
3ko0J-5k04A:
undetectable		 3ko0G-5k04A:
9.64
3ko0H-5k04A:
9.64
3ko0I-5k04A:
9.64
3ko0J-5k04A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 368
ILE A 413
PHE A 420
ASP A 346
SER A 363
 None
 1.23A 3ko0G-5kshA:
undetectable
3ko0H-5kshA:
undetectable
3ko0I-5kshA:
undetectable
3ko0J-5kshA:
undetectable		 3ko0G-5kshA:
10.70
3ko0H-5kshA:
10.70
3ko0I-5kshA:
10.70
3ko0J-5kshA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnb UBIQUITIN-LIKE-SPECI
FIC PROTEASE 2

(Saccharomyces
cerevisiae) 		PF02902
(Peptidase_C48) 		5 LEU B  91
PHE B 185
ILE B 182
CYH B 130
ASP B  59
 None
 1.39A 3ko0G-5lnbB:
undetectable
3ko0H-5lnbB:
undetectable
3ko0I-5lnbB:
undetectable
3ko0J-5lnbB:
undetectable		 3ko0G-5lnbB:
16.50
3ko0H-5lnbB:
16.50
3ko0I-5lnbB:
16.50
3ko0J-5lnbB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 5 GLU A 309
LEU A  65
ILE A  94
ASP A 799
SER A 766
 None
CZA  A1002 (-4.1A)
None
None
None
 1.34A 3ko0G-5mpmA:
undetectable
3ko0H-5mpmA:
undetectable
3ko0I-5mpmA:
undetectable
3ko0J-5mpmA:
undetectable		 3ko0G-5mpmA:
24.47
3ko0H-5mpmA:
24.47
3ko0I-5mpmA:
24.47
3ko0J-5mpmA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 GLU A 135
LEU A 132
SER A 172
PHE A 173
SER A 153
 None
 1.36A 3ko0G-5n6mA:
1.5
3ko0H-5n6mA:
0.9
3ko0I-5n6mA:
1.6
3ko0J-5n6mA:
1.4		 3ko0G-5n6mA:
10.32
3ko0H-5n6mA:
10.32
3ko0I-5n6mA:
10.32
3ko0J-5n6mA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Gloeobacter
violaceus;
Mus musculus) 		no annotation 5 LEU A 401
ILE A 405
PHE A 288
PHE A 295
SER A 240
 None
 1.45A 3ko0G-5osbA:
1.8
3ko0H-5osbA:
1.5
3ko0I-5osbA:
undetectable
3ko0J-5osbA:
1.5		 3ko0G-5osbA:
15.94
3ko0H-5osbA:
15.94
3ko0I-5osbA:
15.94
3ko0J-5osbA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Trypanosoma
brucei) 		PF01536
(SAM_decarbox) 		5 SER A 193
ILE A  98
PHE A 128
PHE A 304
ASP A 169
 None
 1.34A 3ko0G-5tvoA:
undetectable
3ko0H-5tvoA:
undetectable
3ko0I-5tvoA:
undetectable
3ko0J-5tvoA:
undetectable		 3ko0G-5tvoA:
16.79
3ko0H-5tvoA:
16.79
3ko0I-5tvoA:
16.79
3ko0J-5tvoA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uin FORMYLTRANSFERASE

(Salmonella
enterica) 		PF00551
(Formyl_trans_N)
PF13637
(Ank_4) 		5 LEU A 297
SER A 295
ILE A 275
PHE A 232
ASP A 235
 None
 1.24A 3ko0G-5uinA:
undetectable
3ko0H-5uinA:
undetectable
3ko0I-5uinA:
undetectable
3ko0J-5uinA:
undetectable		 3ko0G-5uinA:
13.03
3ko0H-5uinA:
13.03
3ko0I-5uinA:
13.03
3ko0J-5uinA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxv SENSORY TRANSDUCTION
REGULATORY PROTEIN

(Bartonella
quintana) 		no annotation 5 LEU A 127
PHE A  99
ILE A 102
ASP A  65
SER A  89
 None
 1.04A 3ko0G-5uxvA:
undetectable
3ko0H-5uxvA:
undetectable
3ko0I-5uxvA:
undetectable
3ko0J-5uxvA:
undetectable		 3ko0G-5uxvA:
17.59
3ko0H-5uxvA:
17.59
3ko0I-5uxvA:
17.59
3ko0J-5uxvA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 5 PHE B 552
ILE B 582
PHE B 350
PHE B 352
SER B 241
 None
 1.43A 3ko0G-5xguB:
undetectable
3ko0H-5xguB:
undetectable
3ko0I-5xguB:
undetectable
3ko0J-5xguB:
undetectable		 3ko0G-5xguB:
10.73
3ko0H-5xguB:
10.73
3ko0I-5xguB:
10.73
3ko0J-5xguB:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y82 MEMBRANE PROTEIN
INSERTASE YIDC

(Thermotoga
maritima) 		no annotation 5 ASP D 209
LEU D 169
PHE D 193
ILE D 202
PHE D 127
 None
 1.43A 3ko0G-5y82D:
undetectable
3ko0H-5y82D:
undetectable
3ko0I-5y82D:
undetectable
3ko0J-5y82D:
undetectable		 3ko0G-5y82D:
20.62
3ko0H-5y82D:
20.62
3ko0I-5y82D:
20.62
3ko0J-5y82D:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5
GATOR COMPLEX
PROTEIN NPRL2

(Homo sapiens) 		no annotation 5 GLU D 344
ASP D 395
SER D 301
PHE D 343
SER N 187
 None
 1.38A 3ko0G-6cetD:
undetectable
3ko0H-6cetD:
undetectable
3ko0I-6cetD:
undetectable
3ko0J-6cetD:
undetectable		 3ko0G-6cetD:
19.61
3ko0H-6cetD:
19.61
3ko0I-6cetD:
19.61
3ko0J-6cetD:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 5 LEU B 331
ILE B 335
PHE B 289
PHE B 296
SER B 241
 None
 1.36A 3ko0G-6d6uB:
1.9
3ko0H-6d6uB:
undetectable
3ko0I-6d6uB:
undetectable
3ko0J-6d6uB:
undetectable		 3ko0G-6d6uB:
20.39
3ko0H-6d6uB:
20.39
3ko0I-6d6uB:
20.39
3ko0J-6d6uB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
 None
 1.14A 3ko0G-6evjB:
undetectable
3ko0H-6evjB:
undetectable
3ko0I-6evjB:
undetectable
3ko0J-6evjB:
undetectable		 3ko0G-6evjB:
17.92
3ko0H-6evjB:
17.92
3ko0I-6evjB:
17.92
3ko0J-6evjB:
17.92