SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_H_TFPH201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6u NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		5 ILE A 157
PHE A 273
PHE A 114
GLY A  98
PHE A  99
 None
None
None
SO4  A 400 (-3.1A)
None
 1.33A 3ko0H-1m6uA:
undetectable
3ko0I-1m6uA:
undetectable		 3ko0H-1m6uA:
16.09
3ko0I-1m6uA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		5 ILE A 157
PHE A 273
PHE A 114
GLY A  98
PHE A  99
 None
 1.38A 3ko0H-1mnnA:
undetectable
3ko0I-1mnnA:
undetectable		 3ko0H-1mnnA:
14.95
3ko0I-1mnnA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		5 ILE A   3
MET A   1
PRO A 200
PHE A 197
GLY A 119
 None
 1.29A 3ko0H-1r44A:
undetectable
3ko0I-1r44A:
undetectable		 3ko0H-1r44A:
20.69
3ko0I-1r44A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 ILE A 400
PHE A 147
PHE A 187
GLY A   8
PHE A   7
 None
 1.49A 3ko0H-2zwsA:
undetectable
3ko0I-2zwsA:
undetectable		 3ko0H-2zwsA:
9.49
3ko0I-2zwsA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 ILE A1010
PHE A1024
PRO A1021
GLY A 983
PHE A 984
 None
 1.46A 3ko0H-4bocA:
undetectable
3ko0I-4bocA:
0.0		 3ko0H-4bocA:
7.15
3ko0I-4bocA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT

(Ovis aries) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
PF06455
(NADH5_C) 		5 ILE L  62
MET L  82
PHE L  85
GLY L  58
PHE L  54
 None
 1.02A 3ko0H-5lnkL:
undetectable
3ko0I-5lnkL:
undetectable		 3ko0H-5lnkL:
11.50
3ko0I-5lnkL:
11.50