SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_G_TFPG201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 GLY F 273
GLY F 110
ILE F 244
PHE F  84
PHE F 289
 None
 1.46A 3ko0F-1j8mF:
1.8
3ko0G-1j8mF:
1.8		 3ko0F-1j8mF:
15.46
3ko0G-1j8mF:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 GLY A  43
GLY A  95
ILE A 282
PHE A 422
PHE A 425
 HEA  A 601 ( 4.1A)
HEA  A 601 ( 4.0A)
HEA  A 602 ( 4.7A)
None
None
 1.21A 3ko0F-1qleA:
undetectable
3ko0G-1qleA:
undetectable		 3ko0F-1qleA:
10.65
3ko0G-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcy RUSTICYANIN

(Acidithiobacillus
ferrooxidans) 		PF00127
(Copper-bind) 		5 GLY A 150
PHE A  54
GLY A  93
ILE A 105
PHE A  76
 None
 1.24A 3ko0F-1rcyA:
undetectable
3ko0G-1rcyA:
undetectable		 3ko0F-1rcyA:
20.78
3ko0G-1rcyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s40 CELL DIVISION
CONTROL PROTEIN 13

(Saccharomyces
cerevisiae) 		PF02765
(POT1) 		5 GLY A  79
PHE A  80
ILE A 120
CYH A 122
PHE A  31
 None
 1.40A 3ko0F-1s40A:
undetectable
3ko0G-1s40A:
undetectable		 3ko0F-1s40A:
21.32
3ko0G-1s40A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		5 GLY A 240
PHE A 241
GLY A 262
ILE A 136
PHE A 163
 None
 1.39A 3ko0F-1sa3A:
undetectable
3ko0G-1sa3A:
0.1		 3ko0F-1sa3A:
16.03
3ko0G-1sa3A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME

(Homo sapiens) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 GLY A 164
GLY A 160
ILE A  88
CYH A 170
PHE A 173
 ADP  A 901 (-3.1A)
None
None
None
None
 1.18A 3ko0F-1zxnA:
undetectable
3ko0G-1zxnA:
undetectable		 3ko0F-1zxnA:
13.07
3ko0G-1zxnA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 134
PHE A 135
GLY A  92
CYH A  47
PHE A 334
 None
None
None
ZN  A 402 (-2.4A)
None
 1.31A 3ko0F-2cf5A:
undetectable
3ko0G-2cf5A:
0.0		 3ko0F-2cf5A:
13.47
3ko0G-2cf5A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 GLY A 435
PHE A 269
ILE A 237
PHE A 332
PHE A 322
 None
 1.42A 3ko0F-2dpgA:
0.1
3ko0G-2dpgA:
0.0		 3ko0F-2dpgA:
14.91
3ko0G-2dpgA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 120
PHE A 121
GLY A  67
ILE A 146
PHE A 326
 None
 1.31A 3ko0F-2ejvA:
undetectable
3ko0G-2ejvA:
undetectable		 3ko0F-2ejvA:
13.37
3ko0G-2ejvA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		PF00500
(Late_protein_L1) 		5 GLY A 160
PHE A 328
GLY A 243
ILE A 165
PHE A 446
 None
 1.07A 3ko0F-2r5jA:
undetectable
3ko0G-2r5jA:
undetectable		 3ko0F-2r5jA:
13.43
3ko0G-2r5jA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		5 GLY A 200
PHE A 199
GLY A 257
ILE A 206
PHE A 183
 None
 1.30A 3ko0F-2w7yA:
undetectable
3ko0G-2w7yA:
0.0		 3ko0F-2w7yA:
13.38
3ko0G-2w7yA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE

(Enterococcus
faecalis) 		PF02110
(HK) 		5 GLY A 199
PHE A 197
GLY A 205
CYH A 232
PHE A 246
 None
 1.40A 3ko0F-3dzvA:
undetectable
3ko0G-3dzvA:
0.0		 3ko0F-3dzvA:
18.29
3ko0G-3dzvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		5 GLY A 255
GLY A 286
ILE A 279
PHE A 315
PHE A 311
 PO4  A   1 (-3.7A)
None
None
None
None
 1.26A 3ko0F-3f41A:
undetectable
3ko0G-3f41A:
0.0		 3ko0F-3f41A:
10.39
3ko0G-3f41A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		5 PHE A 546
GLY A 583
ILE A 575
MET A 561
PHE A 531
 None
 1.39A 3ko0F-3f41A:
undetectable
3ko0G-3f41A:
0.0		 3ko0F-3f41A:
10.39
3ko0G-3f41A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A 165
PHE A 163
GLY A 333
ILE A  74
PHE A 152
 None
 1.44A 3ko0F-3n6rA:
undetectable
3ko0G-3n6rA:
undetectable		 3ko0F-3n6rA:
10.05
3ko0G-3n6rA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 5 GLY A 250
PHE A 251
GLY A 173
ILE A 204
CYH A 222
 None
 1.20A 3ko0F-3n6zA:
undetectable
3ko0G-3n6zA:
undetectable		 3ko0F-3n6zA:
15.10
3ko0G-3n6zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A 105
PHE A 103
GLY A 273
ILE A  14
PHE A  92
 None
 1.48A 3ko0F-3ouuA:
undetectable
3ko0G-3ouuA:
undetectable		 3ko0F-3ouuA:
11.99
3ko0G-3ouuA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		5 GLY A 401
PHE A 216
GLY A 365
ILE A 310
PHE A  36
 None
 1.49A 3ko0F-3tijA:
undetectable
3ko0G-3tijA:
0.4		 3ko0F-3tijA:
16.43
3ko0G-3tijA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vba ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
SMALL SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00694
(Aconitase_C) 		5 GLY A  60
PHE A  63
GLY A 109
ILE A 105
CYH A  83
 None
 1.31A 3ko0F-3vbaA:
undetectable
3ko0G-3vbaA:
undetectable		 3ko0F-3vbaA:
21.08
3ko0G-3vbaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg8 PA1221

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		5 GLY A 308
PHE A 315
ILE A 187
CYH A 191
PHE A 196
 BU3  A 702 (-4.6A)
None
None
None
None
 1.48A 3ko0F-4dg8A:
undetectable
3ko0G-4dg8A:
0.0		 3ko0F-4dg8A:
9.40
3ko0G-4dg8A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		5 PHE A 446
GLY A 389
ILE A 484
PHE A 416
PHE A 477
 None
None
None
None
EDO  A 511 ( 4.9A)
 1.49A 3ko0F-4fe9A:
undetectable
3ko0G-4fe9A:
undetectable		 3ko0F-4fe9A:
11.54
3ko0G-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		5 GLY A 143
GLY A 139
ILE A  67
CYH A 149
PHE A 152
 ANP  A1202 (-3.1A)
None
None
None
None
 1.21A 3ko0F-4gfhA:
undetectable
3ko0G-4gfhA:
0.0		 3ko0F-4gfhA:
5.97
3ko0G-4gfhA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A

(Homo sapiens;
Legionella
drancourtii) 		PF00071
(Ras)
no annotation 		5 GLY B  69
GLY B  23
ILE B  41
MET A 445
PHE A 448
 AF3  B 401 (-3.7A)
GDP  B 400 (-3.0A)
None
None
None
 1.40A 3ko0F-4jvsB:
undetectable
3ko0G-4jvsB:
undetectable		 3ko0F-4jvsB:
20.99
3ko0G-4jvsB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5y MATERNAL PROTEIN
TUDOR

(Drosophila
melanogaster) 		PF00567
(TUDOR) 		5 GLY A2172
PHE A2292
GLY A2249
ILE A2168
PHE A2329
 None
 1.46A 3ko0F-4q5yA:
undetectable
3ko0G-4q5yA:
undetectable		 3ko0F-4q5yA:
20.08
3ko0G-4q5yA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 GLY A 177
PHE A 198
GLY A 169
ILE A 223
PHE A 219
 None
 1.49A 3ko0F-4wz9A:
undetectable
3ko0G-4wz9A:
0.0		 3ko0F-4wz9A:
9.13
3ko0G-4wz9A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		5 GLY A  75
GLY A 285
CYH A 214
ILE A 212
MET A 198
 None
FAD  A 503 (-3.3A)
None
None
None
 1.42A 3ko0F-4x4jA:
undetectable
3ko0G-4x4jA:
undetectable		 3ko0F-4x4jA:
9.27
3ko0G-4x4jA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 GLY A 150
PHE A 293
GLY A  31
PHE C  75
PHE A 300
 None
None
SF4  A 503 (-3.5A)
None
None
 1.26A 3ko0F-5aa5A:
undetectable
3ko0G-5aa5A:
undetectable		 3ko0F-5aa5A:
16.41
3ko0G-5aa5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 GLY A 150
PHE A 293
GLY A  97
PHE C  75
PHE A 300
 None
None
SF4  A 503 ( 4.3A)
None
None
 1.34A 3ko0F-5aa5A:
undetectable
3ko0G-5aa5A:
undetectable		 3ko0F-5aa5A:
16.41
3ko0G-5aa5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		5 GLY A  74
GLY A  59
ILE A  21
CYH A  23
PHE A 161
 None
 1.41A 3ko0F-5jheA:
undetectable
3ko0G-5jheA:
undetectable		 3ko0F-5jheA:
14.83
3ko0G-5jheA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kew VTRC PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 5 GLY B  85
PHE B 101
ILE B  58
PHE B 148
PHE B 149
 None
 1.45A 3ko0F-5kewB:
undetectable
3ko0G-5kewB:
undetectable		 3ko0F-5kewB:
22.22
3ko0G-5kewB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 5 GLY A 320
GLY A 372
ILE A 334
PHE A 487
PHE A  51
 None
 1.33A 3ko0F-6bzcA:
0.5
3ko0G-6bzcA:
0.6		 3ko0F-6bzcA:
27.08
3ko0G-6bzcA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 5 GLY A 119
GLY A 153
ILE A  93
PHE A 100
PHE A  68
 None
 1.26A 3ko0F-6d0nA:
undetectable
3ko0G-6d0nA:
undetectable		 3ko0F-6d0nA:
24.24
3ko0G-6d0nA:
24.24