SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_C_TFPC201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PHE A 898
GLY A 891
ILE A 876
MET A 855
PHE A 861
 None
 1.49A 3ko0A-1rjbA:
undetectable
3ko0C-1rjbA:
undetectable		 3ko0A-1rjbA:
16.67
3ko0C-1rjbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5s MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Mus musculus) 		PF02149
(KA1) 		5 PHE A  97
PHE A 107
GLY A 122
CYH A  55
CYH A  67
 None
 1.22A 3ko0A-1v5sA:
undetectable
3ko0C-1v5sA:
undetectable		 3ko0A-1v5sA:
23.26
3ko0C-1v5sA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6

(Homo sapiens) 		PF00025
(Arf) 		5 PHE A 128
GLY A 167
ILE A  34
CYH A  22
PHE A  92
 None
 1.44A 3ko0A-2h57A:
undetectable
3ko0C-2h57A:
undetectable		 3ko0A-2h57A:
18.65
3ko0C-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		5 PHE A 371
PHE A 341
ILE A 330
PHE A 378
PHE A 379
 None
 1.13A 3ko0A-2o5rA:
0.6
3ko0C-2o5rA:
undetectable		 3ko0A-2o5rA:
12.33
3ko0C-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PHE A 220
GLY A  36
CYH A  42
ILE A  41
PHE A 184
 None
 1.16A 3ko0A-2qghA:
undetectable
3ko0C-2qghA:
undetectable		 3ko0A-2qghA:
11.76
3ko0C-2qghA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 PHE A 348
PHE A 425
GLY A 203
ILE A 209
PHE A 420
 None
 1.37A 3ko0A-3cj1A:
0.8
3ko0C-3cj1A:
0.7		 3ko0A-3cj1A:
11.67
3ko0C-3cj1A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		5 PHE A 546
GLY A 583
ILE A 575
MET A 561
PHE A 531
 None
 1.46A 3ko0A-3f41A:
undetectable
3ko0C-3f41A:
undetectable		 3ko0A-3f41A:
10.39
3ko0C-3f41A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjj MALTOSE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF12464
(Mac)
PF14602
(Hexapep_2) 		5 PHE A  82
GLY A  99
CYH A  70
ILE A  90
CYH A  88
 None
 1.44A 3ko0A-3hjjA:
undetectable
3ko0C-3hjjA:
undetectable		 3ko0A-3hjjA:
19.27
3ko0C-3hjjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 PHE A 340
GLY A 321
ILE A 263
PHE A 168
PHE A 165
 None
 1.49A 3ko0A-3i3wA:
undetectable
3ko0C-3i3wA:
undetectable		 3ko0A-3i3wA:
14.29
3ko0C-3i3wA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4b PYLD

(Methanosarcina
barkeri) 		no annotation 5 PHE A  74
PHE A  76
CYH A 124
ILE A 128
CYH A  35
 None
 1.36A 3ko0A-4j4bA:
undetectable
3ko0C-4j4bA:
undetectable		 3ko0A-4j4bA:
16.92
3ko0C-4j4bA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		5 PHE A 171
GLY A 299
ILE A 146
PHE A 450
PHE A 311
 None
HEM  A 501 (-3.5A)
None
None
None
 1.47A 3ko0A-5e0eA:
undetectable
3ko0C-5e0eA:
undetectable		 3ko0A-5e0eA:
11.40
3ko0C-5e0eA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF16213
(DCB) 		5 PHE A  81
GLY A 114
CYH A 135
ILE A 134
CYH A  88
 None
 1.17A 3ko0A-5ee5A:
undetectable
3ko0C-5ee5A:
undetectable		 3ko0A-5ee5A:
20.59
3ko0C-5ee5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc5 XAA-PRO DIPEPTIDASE

(Homo sapiens) 		no annotation 5 PHE A  23
GLY A  84
CYH A 183
ILE A 180
PHE A 284
 None
 1.27A 3ko0A-5mc5A:
undetectable
3ko0C-5mc5A:
0.3		 3ko0A-5mc5A:
22.64
3ko0C-5mc5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 5 PHE B 301
PHE B 332
GLY B 298
PHE B 317
PHE B 314
 None
 1.38A 3ko0A-5swiB:
undetectable
3ko0C-5swiB:
undetectable		 3ko0A-5swiB:
10.84
3ko0C-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 PHE A 420
GLY A 135
CYH A 164
PHE A 367
PHE A 428
 None
None
GLY  A 951 (-4.7A)
None
None
 1.25A 3ko0A-5x2qA:
undetectable
3ko0C-5x2qA:
undetectable		 3ko0A-5x2qA:
12.11
3ko0C-5x2qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 5 GLY A1113
CYH A1108
ILE A1136
CYH A1164
PHE A1188
 None
 1.48A 3ko0A-5yudA:
undetectable
3ko0C-5yudA:
undetectable		 3ko0A-5yudA:
25.00
3ko0C-5yudA:
25.00