SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_B_TFPB202_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0u HISTIDINE PERMEASE

(Salmonella
enterica) 		PF00005
(ABC_tran) 		4 LEU A  49
SER A  46
PHE A  48
ILE A  37
 None
ATP  A 301 (-3.1A)
None
None
 0.99A 3ko0B-1b0uA:
0.7		 3ko0B-1b0uA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE

(Salmonella
enterica) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 LEU A  22
SER A  23
PHE A  27
ILE A  30
 None
 0.93A 3ko0B-1bc5A:
0.2		 3ko0B-1bc5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c25 CDC25A

(Homo sapiens) 		PF00581
(Rhodanese) 		4 LEU A 411
PHE A 410
ILE A 382
CYH A 384
 None
 0.93A 3ko0B-1c25A:
undetectable		 3ko0B-1c25A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  55
SER A  53
PHE A  52
ILE A  47
 None
 0.98A 3ko0B-1i2dA:
0.1		 3ko0B-1i2dA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 333
SER A 334
PHE A 336
ILE A 371
 None
 0.95A 3ko0B-1ig8A:
0.0		 3ko0B-1ig8A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw7 HYPOTHETICAL PROTEIN
HP0162

(Helicobacter
pylori) 		PF01709
(Transcrip_reg) 		4 LEU A 109
SER A 111
PHE A 113
ILE A 226
 None
 0.89A 3ko0B-1mw7A:
undetectable		 3ko0B-1mw7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnl L-3-PHOSPHOSERINE
PHOSPHATASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 LEU A 219
PHE A 216
ILE A 177
PHE A 106
 None
 0.97A 3ko0B-1nnlA:
undetectable		 3ko0B-1nnlA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 LEU A 556
PHE A 555
ILE A 139
PHE A 501
 None
 0.95A 3ko0B-1obhA:
undetectable		 3ko0B-1obhA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		4 LEU A  86
PHE A  85
ILE A 184
PHE A 180
 None
 0.90A 3ko0B-1pp0A:
0.2		 3ko0B-1pp0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 LEU A 296
SER A 297
PHE A 301
ILE A 304
 None
 0.94A 3ko0B-1pztA:
undetectable		 3ko0B-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 LEU A 194
SER A 196
PHE A 195
ILE A 294
 None
 0.98A 3ko0B-1tp7A:
0.0		 3ko0B-1tp7A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 LEU A 321
SER A 323
PHE A 325
ILE A 270
 None
 0.96A 3ko0B-1tz7A:
undetectable		 3ko0B-1tz7A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 LEU A 159
PHE A 319
ILE A 281
PHE A 306
 None
 0.93A 3ko0B-1xzwA:
undetectable		 3ko0B-1xzwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A 196
SER A 195
ILE A 188
PHE A 109
 None
 0.96A 3ko0B-1yj8A:
0.0		 3ko0B-1yj8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LEU X 341
SER X 338
ILE X 381
CYH X 385
 None
 0.98A 3ko0B-1z3iX:
undetectable		 3ko0B-1z3iX:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LEU A 492
SER A 484
PHE A 483
ILE A 537
 None
 0.99A 3ko0B-1z63A:
undetectable		 3ko0B-1z63A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbp HYPOTHETICAL PROTEIN
VPA1032

(Vibrio
parahaemolyticus) 		PF07024
(ImpE) 		4 LEU A 104
SER A 106
PHE A 107
ILE A 126
 None
 0.91A 3ko0B-1zbpA:
undetectable		 3ko0B-1zbpA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 LEU A  25
SER A  24
ILE A  36
CYH A  10
 None
 0.95A 3ko0B-1zzmA:
undetectable		 3ko0B-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8

(Homo sapiens) 		no annotation 4 LEU A  64
SER A  66
PHE A  65
ILE A  86
 None
 0.98A 3ko0B-2e8mA:
undetectable		 3ko0B-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		4 LEU A 130
SER A 128
PHE A 129
ILE A 317
 None
 0.68A 3ko0B-2fqxA:
undetectable		 3ko0B-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		4 LEU A 277
SER A 275
PHE A 276
ILE A 300
 None
 0.90A 3ko0B-2gnoA:
2.1		 3ko0B-2gnoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 131
PHE A 167
ILE A 263
CYH A 267
 None
 1.00A 3ko0B-2hnhA:
undetectable		 3ko0B-2hnhA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 142
PHE A 178
ILE A 277
CYH A 281
 None
 0.94A 3ko0B-2hpiA:
undetectable		 3ko0B-2hpiA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihc TRANSCRIPTION
REGULATOR PROTEIN
BACH1

(Homo sapiens) 		PF00651
(BTB) 		4 LEU A  87
PHE A  90
ILE A 118
CYH A 122
 None
 0.98A 3ko0B-2ihcA:
undetectable		 3ko0B-2ihcA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knz UBIQUILIN-4

(Mus musculus) 		PF00627
(UBA) 		4 LEU A  18
SER A  20
PHE A  23
ILE A  44
 None
 0.97A 3ko0B-2knzA:
undetectable		 3ko0B-2knzA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 LEU A 760
SER A 757
PHE A 759
ILE A 652
 None
 1.00A 3ko0B-2oaeA:
undetectable		 3ko0B-2oaeA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 910
PHE A 909
ILE A 888
CYH A 892
 None
 0.78A 3ko0B-2ogvA:
undetectable		 3ko0B-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 LEU A 160
PHE A 320
ILE A 282
PHE A 307
 None
 0.93A 3ko0B-2qfrA:
undetectable		 3ko0B-2qfrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgs PROTEIN SE1688

(Staphylococcus
epidermidis) 		no annotation 4 LEU A 205
PHE A 208
ILE A 171
PHE A 139
 None
 0.88A 3ko0B-2qgsA:
undetectable		 3ko0B-2qgsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		4 LEU A 499
SER A 502
PHE A 503
ILE A 535
 None
 1.00A 3ko0B-2qnaA:
undetectable		 3ko0B-2qnaA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7s UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 LEU A  97
SER A  95
ILE A 223
PHE A  54
 None
 0.95A 3ko0B-3a7sA:
undetectable		 3ko0B-3a7sA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 2

(Mus musculus) 		PF00169
(PH) 		4 SER A 589
ILE A 613
CYH A 617
PHE A 621
 None
 1.00A 3ko0B-3a8pA:
undetectable		 3ko0B-3a8pA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 329
PHE A 330
ILE A  28
PHE A  39
 None
 0.96A 3ko0B-3dtyA:
undetectable		 3ko0B-3dtyA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 LEU A  65
SER A  67
PHE A  69
ILE A 145
 None
 0.87A 3ko0B-3ed3A:
undetectable		 3ko0B-3ed3A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
None
BFD  A 170 ( 4.0A)
None
 0.74A 3ko0B-3ef1A:
undetectable		 3ko0B-3ef1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		4 LEU A 238
SER A 240
ILE A 250
PHE A 196
 None
 0.80A 3ko0B-3ewdA:
undetectable		 3ko0B-3ewdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 476
SER A 475
ILE A 480
CYH A 483
 None
 0.86A 3ko0B-3g2fA:
0.4		 3ko0B-3g2fA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h07 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF00926
(DHBP_synthase) 		4 LEU A   6
SER A   7
PHE A   9
ILE A 189
 None
 0.96A 3ko0B-3h07A:
undetectable		 3ko0B-3h07A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 0.81A 3ko0B-3h11A:
undetectable		 3ko0B-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		4 LEU A 281
PHE A 280
ILE A 256
PHE A 263
 None
 0.98A 3ko0B-3jyoA:
undetectable		 3ko0B-3jyoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 LEU A 152
SER A 151
ILE A 205
CYH A 203
 None
 0.87A 3ko0B-3k28A:
undetectable		 3ko0B-3k28A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		4 LEU A 519
PHE A 520
ILE A 538
PHE A 267
 None
 0.99A 3ko0B-3kxwA:
undetectable		 3ko0B-3kxwA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lho PUTATIVE HYDROLASE

(Shewanella
frigidimarina) 		PF07063
(DUF1338) 		4 LEU A  12
PHE A   9
ILE A  41
PHE A 235
 None
 0.89A 3ko0B-3lhoA:
undetectable		 3ko0B-3lhoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mda DNA POLYMERASE
LAMBDA

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 LEU A 286
SER A 288
PHE A 289
ILE A 302
 None
 0.96A 3ko0B-3mdaA:
undetectable		 3ko0B-3mdaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Marinobacter
hydrocarbonoclasticus) 		PF00440
(TetR_N)
PF13972
(TetR) 		4 LEU A  84
SER A  86
PHE A  88
ILE A 158
 UNL  A 230 ( 4.9A)
None
None
UNL  A 230 ( 4.6A)
 0.95A 3ko0B-3nnrA:
undetectable		 3ko0B-3nnrA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nws CELL DIVISION
CONTROL PROTEIN 13

(Saccharomyces
cerevisiae) 		PF16853
(CDC13_N) 		5 LEU A 115
SER A  43
ILE A  98
CYH A 124
PHE A 125
 None
 1.25A 3ko0B-3nwsA:
undetectable		 3ko0B-3nwsA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 LEU A 185
SER A 116
PHE A 115
ILE A 108
 None
 0.97A 3ko0B-3qanA:
undetectable		 3ko0B-3qanA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 LEU A 332
PHE A 331
ILE A 314
PHE A 293
 None
 0.84A 3ko0B-3rreA:
undetectable		 3ko0B-3rreA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU X 225
SER X 221
ILE X 270
PHE X 274
 None
 0.97A 3ko0B-3rwkX:
undetectable		 3ko0B-3rwkX:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		5 LEU A 340
SER A 343
ILE A 199
CYH A 197
PHE A 195
 None
 1.49A 3ko0B-3t79A:
0.0		 3ko0B-3t79A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 107
SER A 105
ILE A  37
PHE A  52
 None
 0.84A 3ko0B-3toyA:
undetectable		 3ko0B-3toyA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 LEU X 292
SER X 294
ILE X 203
PHE X 192
 None
 0.87A 3ko0B-3utnX:
undetectable		 3ko0B-3utnX:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 LEU A  98
SER A  99
ILE A 111
CYH A 109
 None
 0.97A 3ko0B-3vszA:
undetectable		 3ko0B-3vszA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 LEU A 334
PHE A 333
ILE A 236
PHE A 264
 None
 0.97A 3ko0B-3wnpA:
undetectable		 3ko0B-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		4 LEU A 266
SER A 263
PHE A 265
ILE A 273
 None
 1.00A 3ko0B-3wo8A:
undetectable		 3ko0B-3wo8A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU E 375
SER E 384
PHE E 385
ILE E 350
 None
 1.00A 3ko0B-4a0lE:
undetectable		 3ko0B-4a0lE:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 784
SER A 785
PHE A 789
ILE A 741
 None
 0.83A 3ko0B-4a4zA:
undetectable		 3ko0B-4a4zA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 755
SER A 754
ILE A 676
CYH A 698
 None
 0.98A 3ko0B-4at3A:
undetectable		 3ko0B-4at3A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU H 294
PHE H 295
ILE H 306
CYH H 304
 None
 0.93A 3ko0B-4cr4H:
undetectable		 3ko0B-4cr4H:
11.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eto PROTEIN S100-A4

(Homo sapiens) 		PF01023
(S_100) 		4 LEU A  42
ILE A  82
CYH A  86
PHE A  89
 None
 0.68A 3ko0B-4etoA:
16.8		 3ko0B-4etoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 LEU A  69
SER A  67
PHE A  68
ILE A  58
 LEU  A  69 ( 0.6A)
SER  A  67 ( 0.0A)
PHE  A  68 ( 1.3A)
ILE  A  58 ( 0.7A)
 0.98A 3ko0B-4g9kA:
undetectable		 3ko0B-4g9kA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 4 LEU A 297
SER A 298
ILE A 364
CYH A 277
 None
 0.89A 3ko0B-4gxbA:
undetectable		 3ko0B-4gxbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A 343
ILE A 318
CYH A 362
PHE A 360
 None
 1.00A 3ko0B-4i5jA:
3.7		 3ko0B-4i5jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 LEU A 152
SER A 150
PHE A 151
ILE A  30
PHE A  38
 None
 1.15A 3ko0B-4jhiA:
undetectable		 3ko0B-4jhiA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		4 LEU A 253
PHE A 250
ILE A 215
PHE A 368
 None
 0.97A 3ko0B-4m46A:
undetectable		 3ko0B-4m46A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 LEU A  86
SER A  92
ILE A  55
CYH A  66
 None
 0.87A 3ko0B-4m9dA:
undetectable		 3ko0B-4m9dA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 LEU A 546
SER A 544
PHE A 545
ILE A 504
 None
 1.00A 3ko0B-4ot9A:
undetectable		 3ko0B-4ot9A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 361
SER A 351
PHE A 352
ILE A 390
 None
 0.78A 3ko0B-4pl0A:
undetectable		 3ko0B-4pl0A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF02940
(mRNA_triPase) 		4 LEU A  65
SER A  62
PHE A  64
ILE A 204
 None
 0.97A 3ko0B-4pn0A:
undetectable		 3ko0B-4pn0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Colwellia
psychrerythraea) 		PF02441
(Flavoprotein) 		4 LEU A  67
SER A  64
PHE A  66
ILE A  56
 None
 0.93A 3ko0B-4rheA:
undetectable		 3ko0B-4rheA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		4 LEU A 595
SER A 598
PHE A 600
ILE A 603
 None
 0.87A 3ko0B-4uzyA:
undetectable		 3ko0B-4uzyA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6q GLUCOSYLTRANSFERASE

(Streptococcus
agalactiae) 		no annotation 4 LEU A 328
SER A 326
ILE A  67
PHE A  98
 None
 0.85A 3ko0B-4w6qA:
undetectable		 3ko0B-4w6qA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
 0.69A 3ko0B-4xpzA:
undetectable		 3ko0B-4xpzA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 LEU A 136
SER A 138
PHE A 139
ILE A 188
 None
 1.00A 3ko0B-4yj1A:
undetectable		 3ko0B-4yj1A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 LEU B1002
SER B1000
PHE B 999
ILE B1116
 None
 0.95A 3ko0B-4zktB:
1.2		 3ko0B-4zktB:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 LEU A 447
SER A 454
ILE A 410
PHE A 414
 None
G  C   2 ( 4.4A)
None
A  C   4 ( 4.5A)
 0.75A 3ko0B-5bymA:
undetectable		 3ko0B-5bymA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Francisella
tularensis) 		PF00005
(ABC_tran) 		4 LEU A 387
SER A 378
PHE A 379
ILE A 416
 None
 0.86A 3ko0B-5dgxA:
undetectable		 3ko0B-5dgxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 609
SER A 606
PHE A 608
ILE A 554
 None
 0.94A 3ko0B-5dkuA:
undetectable		 3ko0B-5dkuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.23A 3ko0B-5dwzC:
undetectable		 3ko0B-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 LEU A 291
SER A 253
PHE A 252
ILE A 289
 None
 0.94A 3ko0B-5dzvA:
undetectable		 3ko0B-5dzvA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.96A 3ko0B-5gjvA:
undetectable		 3ko0B-5gjvA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyl LEGUMIN-LIKE PROTEIN

(Cicer arietinum) 		PF00190
(Cupin_1) 		4 LEU A 484
SER A 482
PHE A 483
ILE A 342
 None
 0.94A 3ko0B-5gylA:
undetectable		 3ko0B-5gylA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		4 LEU A 134
SER A 129
PHE A 130
PHE A 102
 None
 0.95A 3ko0B-5hkeA:
undetectable		 3ko0B-5hkeA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		4 LEU A 148
SER A 149
PHE A 153
ILE A 156
 None
 0.90A 3ko0B-5i2qA:
7.4		 3ko0B-5i2qA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilq ASPARTATE
CARBAMOYLTRANSFERASE

(Plasmodium
falciparum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 104
ILE A 128
CYH A 100
PHE A  99
 None
 0.95A 3ko0B-5ilqA:
undetectable		 3ko0B-5ilqA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1803
SER A1800
PHE A1802
ILE A1782
 None
 0.98A 3ko0B-5m5pA:
undetectable		 3ko0B-5m5pA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A2162
PHE A2165
ILE A2138
CYH A2142
 None
 0.68A 3ko0B-5nugA:
undetectable		 3ko0B-5nugA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		4 LEU A 761
SER A 759
PHE A 758
ILE A 738
 None
 0.90A 3ko0B-5nvrA:
undetectable		 3ko0B-5nvrA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 750
SER A 752
PHE A 753
ILE A 774
 None
 0.99A 3ko0B-5nz7A:
undetectable		 3ko0B-5nz7A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opi TAP BINDING
PROTEIN-LIKE VARIANT

(Homo sapiens) 		no annotation 4 LEU C  44
SER C  43
PHE C  77
ILE C 106
 None
 0.99A 3ko0B-5opiC:
undetectable		 3ko0B-5opiC:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pwy NUCLEAR AUTOANTIGEN
SP-100

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A 815
SER A 797
ILE A 840
PHE A 847
 None
 0.92A 3ko0B-5pwyA:
undetectable		 3ko0B-5pwyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0s MEDIATOR COMPLEX
SUBUNIT 6

(Schizosaccharomyces
pombe) 		PF04934
(Med6) 		4 LEU F  34
PHE F  37
ILE F  91
PHE F  87
 None
 0.98A 3ko0B-5u0sF:
undetectable		 3ko0B-5u0sF:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		4 LEU A 345
SER A 342
PHE A 344
ILE A  49
 None
 0.95A 3ko0B-5uldA:
undetectable		 3ko0B-5uldA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 439
ILE A 480
CYH A 494
PHE A 492
 None
 0.84A 3ko0B-5xgeA:
undetectable		 3ko0B-5xgeA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor) 		no annotation 4 LEU A 159
SER A 161
ILE A 153
PHE A 316
 None
 0.73A 3ko0B-5z0cA:
undetectable		 3ko0B-5z0cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 4 LEU A 208
SER A 205
PHE A 207
ILE A 182
 None
 0.98A 3ko0B-6bacA:
undetectable		 3ko0B-6bacA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.98A 3ko0B-6byoA:
undetectable		 3ko0B-6byoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 4 LEU A 431
SER A 433
PHE A 434
ILE A 780
 None
 0.97A 3ko0B-6d4jA:
undetectable		 3ko0B-6d4jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 4 LEU A 170
SER A 167
PHE A 169
ILE A 102
 None
 0.98A 3ko0B-6emsA:
undetectable		 3ko0B-6emsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 LEU B 102
PHE B 103
ILE B 262
PHE B 254
 None
 0.89A 3ko0B-6evjB:
undetectable		 3ko0B-6evjB:
17.92