SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_B_TFPB202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bl5 ISOCITRATE
DEHYDROGENASE

(Escherichia
coli) 		PF00180
(Iso_dh) 		3 GLU A 121
LEU A 122
ASP A 123
 None
 0.44A 3ko0A-1bl5A:
undetectable		 3ko0A-1bl5A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2y PROTEIN (LUMAZINE
SYNTHASE)

(Spinacia
oleracea) 		PF00885
(DMRL_synthase) 		3 GLU A  33
LEU A  36
ASP A  37
 None
 0.42A 3ko0A-1c2yA:
undetectable		 3ko0A-1c2yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		3 GLU A 311
LEU A 308
ASP A 307
 None
 0.48A 3ko0A-1ituA:
undetectable		 3ko0A-1ituA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 GLU A 294
LEU A 291
ASP A 290
 None
 0.43A 3ko0A-1kczA:
undetectable		 3ko0A-1kczA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1j HEAT SHOCK PROTEASE
HTRA

(Thermotoga
maritima) 		PF13365
(Trypsin_2) 		3 GLU A 125
LEU A 126
ASP A 127
 None
 0.44A 3ko0A-1l1jA:
undetectable		 3ko0A-1l1jA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		3 GLU A 131
LEU A 128
ASP A 129
 None
 0.48A 3ko0A-1n97A:
undetectable		 3ko0A-1n97A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 GLU A 343
LEU A 346
ASP A 347
 None
 0.25A 3ko0A-1obbA:
undetectable		 3ko0A-1obbA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT

(Homo sapiens) 		PF08785
(Ku_PK_bind) 		3 GLU A  63
LEU A  66
ASP A  67
 None
 0.28A 3ko0A-1rw2A:
undetectable		 3ko0A-1rw2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		3 GLU A 163
LEU A 166
ASP A 167
 None
 0.42A 3ko0A-1tdhA:
1.4		 3ko0A-1tdhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjk MOLYBDOPTERIN
CONVERTING FACTOR,
SUBUNIT 1

(Pyrococcus
furiosus) 		PF02597
(ThiS) 		3 GLU A  37
LEU A  34
ASP A  33
 None
 0.47A 3ko0A-1vjkA:
undetectable		 3ko0A-1vjkA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vki HYPOTHETICAL PROTEIN
ATU3699

(Agrobacterium
fabrum) 		PF04073
(tRNA_edit) 		3 GLU A  67
LEU A 127
ASP A 126
 None
 0.35A 3ko0A-1vkiA:
undetectable		 3ko0A-1vkiA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgn UBIQUITIN ASSOCIATED
PROTEIN

(Homo sapiens) 		no annotation 3 GLU A  48
LEU A  51
ASP A  52
 None
 0.21A 3ko0A-1wgnA:
undetectable		 3ko0A-1wgnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 GLU A  13
LEU A  14
ASP A  15
 None
 0.49A 3ko0A-1x55A:
1.4		 3ko0A-1x55A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9u UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF08969
(USP8_dimer) 		3 GLU A  49
LEU A  52
ASP A  53
 None
 0.45A 3ko0A-2a9uA:
undetectable		 3ko0A-2a9uA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		3 GLU A 130
LEU A 133
ASP A 134
 None
 0.27A 3ko0A-2bnhA:
undetectable		 3ko0A-2bnhA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2din CELL DIVISION CYCLE
5-LIKE PROTEIN

(Homo sapiens) 		PF00249
(Myb_DNA-binding) 		3 GLU A  50
LEU A  53
ASP A  54
 None
 0.35A 3ko0A-2dinA:
undetectable		 3ko0A-2dinA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLU A  63
LEU A  66
ASP A  67
 None
 0.48A 3ko0A-2dzdA:
undetectable		 3ko0A-2dzdA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLU A 112
LEU A 115
ASP A 116
 None
 0.39A 3ko0A-2dzdA:
undetectable		 3ko0A-2dzdA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 GLU A 329
LEU A 332
ASP A 333
 None
 0.28A 3ko0A-2e9fA:
0.9		 3ko0A-2e9fA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 GLU A 572
LEU A 575
ASP A 576
 None
 0.46A 3ko0A-2h4tA:
undetectable		 3ko0A-2h4tA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		3 GLU A  58
LEU A  61
ASP A  62
 None
 0.48A 3ko0A-2i10A:
1.3		 3ko0A-2i10A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1d DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1

(Homo sapiens) 		PF02181
(FH2) 		3 GLU G 746
LEU G 743
ASP G 742
 None
 0.45A 3ko0A-2j1dG:
undetectable		 3ko0A-2j1dG:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5b TYROSYL-TRNA
SYNTHETASE

(Acanthamoeba
polyphaga
mimivirus) 		PF00579
(tRNA-synt_1b) 		3 GLU A 125
LEU A 128
ASP A 129
 GLU  A 125 ( 0.6A)
LEU  A 128 ( 0.6A)
ASP  A 129 ( 0.6A)
 0.31A 3ko0A-2j5bA:
undetectable		 3ko0A-2j5bA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khz C-MYC-RESPONSIVE
PROTEIN RCL

(Rattus
norvegicus) 		PF05014
(Nuc_deoxyrib_tr) 		3 GLU A 140
LEU A 143
ASP A 144
 None
 0.47A 3ko0A-2khzA:
undetectable		 3ko0A-2khzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6c THIOREDOXIN

(Desulfovibrio
vulgaris) 		PF00085
(Thioredoxin) 		3 GLU A  38
LEU A  41
ASP A  42
 None
 0.48A 3ko0A-2l6cA:
undetectable		 3ko0A-2l6cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lse FOUR HELIX BUNDLE
PROTEIN

(synthetic
construct) 		no annotation 3 GLU A  13
LEU A  16
ASP A  17
 None
 0.29A 3ko0A-2lseA:
undetectable		 3ko0A-2lseA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mn2 YMOB

(Yersinia
enterocolitica) 		PF10757
(YbaJ) 		3 GLU A  77
LEU A  80
ASP A  81
 None
 0.37A 3ko0A-2mn2A:
undetectable		 3ko0A-2mn2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		3 GLU A 232
LEU A 229
ASP A 228
 None
 0.44A 3ko0A-2o7rA:
undetectable		 3ko0A-2o7rA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME

(Burkholderia
pseudomallei) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 160
LEU A 163
ASP A 164
 None
 0.41A 3ko0A-2podA:
undetectable		 3ko0A-2podA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		3 GLU A 172
LEU A 175
ASP A 176
 None
 0.44A 3ko0A-2raeA:
undetectable		 3ko0A-2raeA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLU A 459
LEU A 462
ASP A 463
 None
 0.22A 3ko0A-2rvjA:
undetectable		 3ko0A-2rvjA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tmk THYMIDYLATE KINASE

(Saccharomyces
cerevisiae) 		PF02223
(Thymidylate_kin) 		3 GLU A 171
LEU A 168
ASP A 169
 None
 0.40A 3ko0A-2tmkA:
undetectable		 3ko0A-2tmkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT

(Bacillus phage
SPP1) 		PF17288
(Terminase_3C) 		3 GLU A 354
LEU A 357
ASP A 358
 None
 0.23A 3ko0A-2wbnA:
undetectable		 3ko0A-2wbnA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh3 SPD1 NUCLEASE

(Streptococcus
pyogenes) 		PF13930
(Endonuclea_NS_2) 		3 GLU A 164
LEU A 167
ASP A 168
 None
 0.34A 3ko0A-2xh3A:
undetectable		 3ko0A-2xh3A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7e NIFU-LIKE PROTEIN

(Aquifex
aeolicus) 		PF01592
(NifU_N) 		3 GLU A   7
LEU A  10
ASP A  11
 None
 0.38A 3ko0A-2z7eA:
undetectable		 3ko0A-2z7eA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		3 GLU A 138
LEU A 139
ASP A 140
 None
 0.47A 3ko0A-3a6pA:
undetectable		 3ko0A-3a6pA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE

(Escherichia
coli) 		PF05958
(tRNA_U5-meth_tr) 		3 GLU A 201
LEU A 204
ASP A 205
 None
 0.27A 3ko0A-3bt7A:
undetectable		 3ko0A-3bt7A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c90 PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE

(Mycobacterium
tuberculosis) 		no annotation 3 GLU X  16
LEU X  13
ASP X  12
 None
 0.40A 3ko0A-3c90X:
undetectable		 3ko0A-3c90X:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crl DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX,
MITOCHONDRIAL

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		3 GLU C 179
LEU C 165
ASP C 164
 None
 0.39A 3ko0A-3crlC:
undetectable		 3ko0A-3crlC:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA

(Candida
albicans) 		PF01239
(PPTA) 		3 GLU A  94
LEU A  97
ASP A  98
 None
 0.26A 3ko0A-3draA:
undetectable		 3ko0A-3draA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC

(Oryza sativa) 		no annotation 3 GLU O 139
LEU O 329
ASP O 328
 None
 0.38A 3ko0A-3e6aO:
undetectable		 3ko0A-3e6aO:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd9 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF16806
(ExsD) 		3 GLU A 132
LEU A 135
ASP A 136
 None
 0.41A 3ko0A-3fd9A:
undetectable		 3ko0A-3fd9A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6i PUTATIVE OUTER
MEMBRANE PROTEIN,
PART OF CARBOHYDRATE
BINDING COMPLEX

(Bacteroides
thetaiotaomicron) 		PF12875
(DUF3826) 		3 GLU A 145
LEU A 148
ASP A 149
 None
 0.28A 3ko0A-3g6iA:
undetectable		 3ko0A-3g6iA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Marinobacter
hydrocarbonoclasticus) 		PF00365
(PFK) 		3 GLU A 169
LEU A 172
ASP A 173
 None
 0.22A 3ko0A-3k2qA:
undetectable		 3ko0A-3k2qA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 GLU A 215
LEU A 218
ASP A 219
 None
 0.32A 3ko0A-3k30A:
undetectable		 3ko0A-3k30A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 GLU A 294
LEU A 297
ASP A 298
 None
 0.36A 3ko0A-3l7gA:
undetectable		 3ko0A-3l7gA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgj UNCHARACTERIZED
PROTEIN MJ1480

(Methanocaldococcus
jannaschii) 		PF04455
(Saccharop_dh_N) 		3 GLU A  74
LEU A  71
ASP A  70
 None
 0.39A 3ko0A-3mgjA:
undetectable		 3ko0A-3mgjA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 GLU A  99
LEU A 495
ASP A 494
 None
 0.46A 3ko0A-3o5aA:
undetectable		 3ko0A-3o5aA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		3 GLU A 150
LEU A 153
ASP A 154
 None
 0.34A 3ko0A-3pl5A:
undetectable		 3ko0A-3pl5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		3 GLU A 417
LEU A 420
ASP A 421
 EDO  A 433 ( 4.4A)
EDO  A 435 ( 4.5A)
None
 0.36A 3ko0A-3qpfA:
undetectable		 3ko0A-3qpfA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzy BACULOVIRUS
SULFHYDRYL OXIDASE
AC92

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		3 GLU A 177
LEU A 180
ASP A 181
 None
 0.47A 3ko0A-3qzyA:
1.7		 3ko0A-3qzyA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 GLU A  76
LEU A  79
ASP A  80
 None
 0.22A 3ko0A-3rv2A:
undetectable		 3ko0A-3rv2A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 GLU A 330
LEU A 333
ASP A 334
 None
 0.47A 3ko0A-3rx8A:
undetectable		 3ko0A-3rx8A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shr CGMP-DEPENDENT
PROTEIN KINASE 1

(Bos taurus) 		PF00027
(cNMP_binding) 		3 GLU A  95
LEU A  98
ASP A  99
 None
 0.44A 3ko0A-3shrA:
undetectable		 3ko0A-3shrA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 151
LEU A 154
ASP A 155
 None
 0.41A 3ko0A-3t4wA:
undetectable		 3ko0A-3t4wA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		3 GLU A  19
LEU A  22
ASP A  23
 None
 0.36A 3ko0A-3ts7A:
undetectable		 3ko0A-3ts7A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		3 GLU A 258
LEU A 261
ASP A 262
 None
 0.35A 3ko0A-3vvlA:
undetectable		 3ko0A-3vvlA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		3 GLU A 313
LEU A 316
ASP A 317
 None
 0.43A 3ko0A-3vz0A:
undetectable		 3ko0A-3vz0A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ack TSSL

(Francisella
tularensis) 		PF09850
(DotU) 		3 GLU A   8
LEU A  11
ASP A  12
 None
None
BR  A1156 ( 4.4A)
 0.45A 3ko0A-4ackA:
undetectable		 3ko0A-4ackA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am2 BACTERIOFERRITIN

(Blastochloris
viridis) 		PF00210
(Ferritin) 		3 GLU A 135
LEU A 138
ASP A 139
 None
 0.43A 3ko0A-4am2A:
undetectable		 3ko0A-4am2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axz PUTATIVE ANTIGEN P35

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		3 GLU A 270
LEU A 271
ASP A 272
 None
 0.45A 3ko0A-4axzA:
1.1		 3ko0A-4axzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csq UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 GLU A  34
LEU A  37
ASP A  38
 None
 0.36A 3ko0A-4csqA:
undetectable		 3ko0A-4csqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee9 ENDOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 GLU A 253
LEU A 256
ASP A 257
 None
 0.30A 3ko0A-4ee9A:
undetectable		 3ko0A-4ee9A:
12.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eto PROTEIN S100-A4

(Homo sapiens) 		PF01023
(S_100) 		3 GLU A   6
LEU A   9
ASP A  10
 None
 0.28A 3ko0A-4etoA:
16.8		 3ko0A-4etoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd6 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
2

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		3 GLU A 157
LEU A 160
ASP A 161
 None
 0.39A 3ko0A-4fd6A:
undetectable		 3ko0A-4fd6A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn3 LMO1757 PROTEIN

(Listeria
monocytogenes) 		PF07537
(CamS) 		3 GLU A 110
LEU A 113
ASP A 114
 None
 0.22A 3ko0A-4hn3A:
undetectable		 3ko0A-4hn3A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		3 GLU A  99
LEU A 102
ASP A 103
 None
 0.36A 3ko0A-4hz8A:
undetectable		 3ko0A-4hz8A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 GLU A 438
LEU A 441
ASP A 442
 None
 0.46A 3ko0A-4i5jA:
undetectable		 3ko0A-4i5jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		3 GLU A1117
LEU A1114
ASP A1113
 None
 0.43A 3ko0A-4i99A:
undetectable		 3ko0A-4i99A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		3 GLU A 266
LEU A 269
ASP A 270
 None
 0.36A 3ko0A-4kbmA:
undetectable		 3ko0A-4kbmA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3u UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF16133
(DUF4844) 		3 GLU A 124
LEU A 127
ASP A 128
 None
 0.39A 3ko0A-4l3uA:
undetectable		 3ko0A-4l3uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne5 CENTROMERE PROTEIN S

(Homo sapiens) 		PF15630
(CENP-S) 		3 GLU A  33
LEU A  36
ASP A  37
 None
 0.43A 3ko0A-4ne5A:
undetectable		 3ko0A-4ne5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 3 GLU B 193
LEU B 196
ASP B 197
 None
 0.46A 3ko0A-4pl2B:
undetectable		 3ko0A-4pl2B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		3 GLU A  39
LEU A  42
ASP A  43
 None
 0.28A 3ko0A-4r9oA:
undetectable		 3ko0A-4r9oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Bacillus
subtilis) 		PF11638
(DnaA_N) 		3 GLU B   2
LEU B   5
ASP B   6
 None
 0.37A 3ko0A-4tpsB:
undetectable		 3ko0A-4tpsB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 3 GLU A 185
LEU A 188
ASP A 189
 None
 0.24A 3ko0A-4xxnA:
undetectable		 3ko0A-4xxnA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 3 GLU A 185
LEU A 188
ASP A 189
 None
 0.30A 3ko0A-4xy3A:
undetectable		 3ko0A-4xy3A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 GLU O 134
LEU O 324
ASP O 323
 None
 0.38A 3ko0A-4z0hO:
undetectable		 3ko0A-4z0hO:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 GLU A 294
LEU A 297
ASP A 298
 None
 0.19A 3ko0A-4zwoA:
undetectable		 3ko0A-4zwoA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		3 GLU A 351
LEU A 354
ASP A 355
 None
 0.29A 3ko0A-5abmA:
undetectable		 3ko0A-5abmA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aon PEROXIN 14

(Trypanosoma
brucei) 		PF04695
(Pex14_N) 		3 GLU A  34
LEU A  37
ASP A  38
 None
 0.47A 3ko0A-5aonA:
undetectable		 3ko0A-5aonA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bux 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ

(Yersinia pestis) 		PF07977
(FabA) 		3 GLU A  11
LEU A  14
ASP A  15
 None
 0.34A 3ko0A-5buxA:
undetectable		 3ko0A-5buxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		3 GLU A 424
LEU A  42
ASP A  41
 None
 0.43A 3ko0A-5cqfA:
undetectable		 3ko0A-5cqfA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e57 TRANSCRIPTION
REGULATOR AMTR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		3 GLU A  24
LEU A  27
ASP A  28
 None
 0.25A 3ko0A-5e57A:
1.0		 3ko0A-5e57A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		3 GLU A  14
LEU A  17
ASP A  18
 None
 0.31A 3ko0A-5eo6A:
undetectable		 3ko0A-5eo6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Symbiobacterium
thermophilum) 		PF00282
(Pyridoxal_deC) 		3 GLU A 372
LEU A 375
ASP A 376
 None
 0.28A 3ko0A-5eueA:
undetectable		 3ko0A-5eueA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itq ENDONUCLEASE 8-LIKE
1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		3 GLU A 163
LEU A 166
ASP A 167
 None
 0.46A 3ko0A-5itqA:
undetectable		 3ko0A-5itqA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kht TROPOMYOSIN ALPHA-1
CHAIN,GENERAL
CONTROL PROTEIN GCN4

(Homo sapiens;
Saccharomyces
cerevisiae) 		no annotation 3 GLU A  16
LEU A  19
ASP A  20
 None
 0.21A 3ko0A-5khtA:
undetectable		 3ko0A-5khtA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		3 GLU A 407
LEU A 410
ASP A 411
 None
 0.35A 3ko0A-5mscA:
undetectable		 3ko0A-5mscA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B

(Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG) 		3 GLU B 206
LEU B 209
ASP B 210
 None
 0.25A 3ko0A-5odrB:
undetectable		 3ko0A-5odrB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 3 GLU B  49
LEU B  52
ASP B  53
 None
 0.23A 3ko0A-5oetB:
undetectable		 3ko0A-5oetB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN

(Squalimorphii) 		PF00566
(RabGAP-TBC) 		3 GLU A 509
LEU A 470
ASP A 469
 None
 0.39A 3ko0A-5tubA:
1.9		 3ko0A-5tubA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vr3 BRAF

(Homo sapiens) 		no annotation 3 GLU A  62
LEU A  65
ASP A  66
 None
 0.28A 3ko0A-5vr3A:
undetectable		 3ko0A-5vr3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF

(Homo sapiens) 		no annotation 3 GLU A1062
LEU A1065
ASP A1066
 None
 0.36A 3ko0A-5vykA:
undetectable		 3ko0A-5vykA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		3 GLU A1117
LEU A1114
ASP A1113
 None
 0.41A 3ko0A-5xnsA:
undetectable		 3ko0A-5xnsA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 GLU B 320
LEU B 323
ASP B 324
 None
 0.45A 3ko0A-5xogB:
undetectable		 3ko0A-5xogB:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 3 GLU A 162
LEU A 165
ASP A 166
 None
 0.33A 3ko0A-5yhpA:
undetectable		 3ko0A-5yhpA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 3 GLU A1813
LEU A1712
ASP A1713
 None
 0.45A 3ko0A-5zalA:
undetectable		 3ko0A-5zalA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 3 GLU A 230
LEU A 532
ASP A 531
 None
 0.46A 3ko0A-6begA:
undetectable		 3ko0A-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ggp AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		no annotation 3 GLU A  60
LEU A  57
ASP A  56
 None
 0.47A 3ko0A-6ggpA:
undetectable		 3ko0A-6ggpA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0u HISTIDINE PERMEASE

(Salmonella
enterica) 		PF00005
(ABC_tran) 		4 LEU A  49
SER A  46
PHE A  48
ILE A  37
 None
ATP  A 301 (-3.1A)
None
None
 0.99A 3ko0B-1b0uA:
0.7		 3ko0B-1b0uA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE

(Salmonella
enterica) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 LEU A  22
SER A  23
PHE A  27
ILE A  30
 None
 0.93A 3ko0B-1bc5A:
0.2		 3ko0B-1bc5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c25 CDC25A

(Homo sapiens) 		PF00581
(Rhodanese) 		4 LEU A 411
PHE A 410
ILE A 382
CYH A 384
 None
 0.93A 3ko0B-1c25A:
undetectable		 3ko0B-1c25A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  55
SER A  53
PHE A  52
ILE A  47
 None
 0.98A 3ko0B-1i2dA:
0.1		 3ko0B-1i2dA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 333
SER A 334
PHE A 336
ILE A 371
 None
 0.95A 3ko0B-1ig8A:
0.0		 3ko0B-1ig8A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw7 HYPOTHETICAL PROTEIN
HP0162

(Helicobacter
pylori) 		PF01709
(Transcrip_reg) 		4 LEU A 109
SER A 111
PHE A 113
ILE A 226
 None
 0.89A 3ko0B-1mw7A:
undetectable		 3ko0B-1mw7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnl L-3-PHOSPHOSERINE
PHOSPHATASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 LEU A 219
PHE A 216
ILE A 177
PHE A 106
 None
 0.97A 3ko0B-1nnlA:
undetectable		 3ko0B-1nnlA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 LEU A 556
PHE A 555
ILE A 139
PHE A 501
 None
 0.95A 3ko0B-1obhA:
undetectable		 3ko0B-1obhA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		4 LEU A  86
PHE A  85
ILE A 184
PHE A 180
 None
 0.90A 3ko0B-1pp0A:
0.2		 3ko0B-1pp0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 LEU A 296
SER A 297
PHE A 301
ILE A 304
 None
 0.94A 3ko0B-1pztA:
undetectable		 3ko0B-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 LEU A 194
SER A 196
PHE A 195
ILE A 294
 None
 0.98A 3ko0B-1tp7A:
0.0		 3ko0B-1tp7A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 LEU A 321
SER A 323
PHE A 325
ILE A 270
 None
 0.96A 3ko0B-1tz7A:
undetectable		 3ko0B-1tz7A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 LEU A 159
PHE A 319
ILE A 281
PHE A 306
 None
 0.93A 3ko0B-1xzwA:
undetectable		 3ko0B-1xzwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A 196
SER A 195
ILE A 188
PHE A 109
 None
 0.96A 3ko0B-1yj8A:
0.0		 3ko0B-1yj8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LEU X 341
SER X 338
ILE X 381
CYH X 385
 None
 0.98A 3ko0B-1z3iX:
undetectable		 3ko0B-1z3iX:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LEU A 492
SER A 484
PHE A 483
ILE A 537
 None
 0.99A 3ko0B-1z63A:
undetectable		 3ko0B-1z63A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbp HYPOTHETICAL PROTEIN
VPA1032

(Vibrio
parahaemolyticus) 		PF07024
(ImpE) 		4 LEU A 104
SER A 106
PHE A 107
ILE A 126
 None
 0.91A 3ko0B-1zbpA:
undetectable		 3ko0B-1zbpA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 LEU A  25
SER A  24
ILE A  36
CYH A  10
 None
 0.95A 3ko0B-1zzmA:
undetectable		 3ko0B-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8

(Homo sapiens) 		no annotation 4 LEU A  64
SER A  66
PHE A  65
ILE A  86
 None
 0.98A 3ko0B-2e8mA:
undetectable		 3ko0B-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		4 LEU A 130
SER A 128
PHE A 129
ILE A 317
 None
 0.68A 3ko0B-2fqxA:
undetectable		 3ko0B-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		4 LEU A 277
SER A 275
PHE A 276
ILE A 300
 None
 0.90A 3ko0B-2gnoA:
2.1		 3ko0B-2gnoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 131
PHE A 167
ILE A 263
CYH A 267
 None
 1.00A 3ko0B-2hnhA:
undetectable		 3ko0B-2hnhA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 142
PHE A 178
ILE A 277
CYH A 281
 None
 0.94A 3ko0B-2hpiA:
undetectable		 3ko0B-2hpiA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihc TRANSCRIPTION
REGULATOR PROTEIN
BACH1

(Homo sapiens) 		PF00651
(BTB) 		4 LEU A  87
PHE A  90
ILE A 118
CYH A 122
 None
 0.98A 3ko0B-2ihcA:
undetectable		 3ko0B-2ihcA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knz UBIQUILIN-4

(Mus musculus) 		PF00627
(UBA) 		4 LEU A  18
SER A  20
PHE A  23
ILE A  44
 None
 0.97A 3ko0B-2knzA:
undetectable		 3ko0B-2knzA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 LEU A 760
SER A 757
PHE A 759
ILE A 652
 None
 1.00A 3ko0B-2oaeA:
undetectable		 3ko0B-2oaeA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 910
PHE A 909
ILE A 888
CYH A 892
 None
 0.78A 3ko0B-2ogvA:
undetectable		 3ko0B-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 LEU A 160
PHE A 320
ILE A 282
PHE A 307
 None
 0.93A 3ko0B-2qfrA:
undetectable		 3ko0B-2qfrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgs PROTEIN SE1688

(Staphylococcus
epidermidis) 		no annotation 4 LEU A 205
PHE A 208
ILE A 171
PHE A 139
 None
 0.88A 3ko0B-2qgsA:
undetectable		 3ko0B-2qgsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		4 LEU A 499
SER A 502
PHE A 503
ILE A 535
 None
 1.00A 3ko0B-2qnaA:
undetectable		 3ko0B-2qnaA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7s UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 LEU A  97
SER A  95
ILE A 223
PHE A  54
 None
 0.95A 3ko0B-3a7sA:
undetectable		 3ko0B-3a7sA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 2

(Mus musculus) 		PF00169
(PH) 		4 SER A 589
ILE A 613
CYH A 617
PHE A 621
 None
 1.00A 3ko0B-3a8pA:
undetectable		 3ko0B-3a8pA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 329
PHE A 330
ILE A  28
PHE A  39
 None
 0.96A 3ko0B-3dtyA:
undetectable		 3ko0B-3dtyA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 LEU A  65
SER A  67
PHE A  69
ILE A 145
 None
 0.87A 3ko0B-3ed3A:
undetectable		 3ko0B-3ed3A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
None
BFD  A 170 ( 4.0A)
None
 0.74A 3ko0B-3ef1A:
undetectable		 3ko0B-3ef1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		4 LEU A 238
SER A 240
ILE A 250
PHE A 196
 None
 0.80A 3ko0B-3ewdA:
undetectable		 3ko0B-3ewdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 476
SER A 475
ILE A 480
CYH A 483
 None
 0.86A 3ko0B-3g2fA:
0.4		 3ko0B-3g2fA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h07 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF00926
(DHBP_synthase) 		4 LEU A   6
SER A   7
PHE A   9
ILE A 189
 None
 0.96A 3ko0B-3h07A:
undetectable		 3ko0B-3h07A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 0.81A 3ko0B-3h11A:
undetectable		 3ko0B-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		4 LEU A 281
PHE A 280
ILE A 256
PHE A 263
 None
 0.98A 3ko0B-3jyoA:
undetectable		 3ko0B-3jyoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 LEU A 152
SER A 151
ILE A 205
CYH A 203
 None
 0.87A 3ko0B-3k28A:
undetectable		 3ko0B-3k28A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		4 LEU A 519
PHE A 520
ILE A 538
PHE A 267
 None
 0.99A 3ko0B-3kxwA:
undetectable		 3ko0B-3kxwA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lho PUTATIVE HYDROLASE

(Shewanella
frigidimarina) 		PF07063
(DUF1338) 		4 LEU A  12
PHE A   9
ILE A  41
PHE A 235
 None
 0.89A 3ko0B-3lhoA:
undetectable		 3ko0B-3lhoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mda DNA POLYMERASE
LAMBDA

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 LEU A 286
SER A 288
PHE A 289
ILE A 302
 None
 0.96A 3ko0B-3mdaA:
undetectable		 3ko0B-3mdaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Marinobacter
hydrocarbonoclasticus) 		PF00440
(TetR_N)
PF13972
(TetR) 		4 LEU A  84
SER A  86
PHE A  88
ILE A 158
 UNL  A 230 ( 4.9A)
None
None
UNL  A 230 ( 4.6A)
 0.95A 3ko0B-3nnrA:
undetectable		 3ko0B-3nnrA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nws CELL DIVISION
CONTROL PROTEIN 13

(Saccharomyces
cerevisiae) 		PF16853
(CDC13_N) 		5 LEU A 115
SER A  43
ILE A  98
CYH A 124
PHE A 125
 None
 1.25A 3ko0B-3nwsA:
undetectable		 3ko0B-3nwsA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 LEU A 185
SER A 116
PHE A 115
ILE A 108
 None
 0.97A 3ko0B-3qanA:
undetectable		 3ko0B-3qanA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 LEU A 332
PHE A 331
ILE A 314
PHE A 293
 None
 0.84A 3ko0B-3rreA:
undetectable		 3ko0B-3rreA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU X 225
SER X 221
ILE X 270
PHE X 274
 None
 0.97A 3ko0B-3rwkX:
undetectable		 3ko0B-3rwkX:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		5 LEU A 340
SER A 343
ILE A 199
CYH A 197
PHE A 195
 None
 1.49A 3ko0B-3t79A:
0.0		 3ko0B-3t79A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 107
SER A 105
ILE A  37
PHE A  52
 None
 0.84A 3ko0B-3toyA:
undetectable		 3ko0B-3toyA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 LEU X 292
SER X 294
ILE X 203
PHE X 192
 None
 0.87A 3ko0B-3utnX:
undetectable		 3ko0B-3utnX:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 LEU A  98
SER A  99
ILE A 111
CYH A 109
 None
 0.97A 3ko0B-3vszA:
undetectable		 3ko0B-3vszA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 LEU A 334
PHE A 333
ILE A 236
PHE A 264
 None
 0.97A 3ko0B-3wnpA:
undetectable		 3ko0B-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		4 LEU A 266
SER A 263
PHE A 265
ILE A 273
 None
 1.00A 3ko0B-3wo8A:
undetectable		 3ko0B-3wo8A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU E 375
SER E 384
PHE E 385
ILE E 350
 None
 1.00A 3ko0B-4a0lE:
undetectable		 3ko0B-4a0lE:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 784
SER A 785
PHE A 789
ILE A 741
 None
 0.83A 3ko0B-4a4zA:
undetectable		 3ko0B-4a4zA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 755
SER A 754
ILE A 676
CYH A 698
 None
 0.98A 3ko0B-4at3A:
undetectable		 3ko0B-4at3A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU H 294
PHE H 295
ILE H 306
CYH H 304
 None
 0.93A 3ko0B-4cr4H:
undetectable		 3ko0B-4cr4H:
11.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eto PROTEIN S100-A4

(Homo sapiens) 		PF01023
(S_100) 		4 LEU A  42
ILE A  82
CYH A  86
PHE A  89
 None
 0.68A 3ko0B-4etoA:
16.8		 3ko0B-4etoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 LEU A  69
SER A  67
PHE A  68
ILE A  58
 LEU  A  69 ( 0.6A)
SER  A  67 ( 0.0A)
PHE  A  68 ( 1.3A)
ILE  A  58 ( 0.7A)
 0.98A 3ko0B-4g9kA:
undetectable		 3ko0B-4g9kA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 4 LEU A 297
SER A 298
ILE A 364
CYH A 277
 None
 0.89A 3ko0B-4gxbA:
undetectable		 3ko0B-4gxbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A 343
ILE A 318
CYH A 362
PHE A 360
 None
 1.00A 3ko0B-4i5jA:
3.7		 3ko0B-4i5jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 LEU A 152
SER A 150
PHE A 151
ILE A  30
PHE A  38
 None
 1.15A 3ko0B-4jhiA:
undetectable		 3ko0B-4jhiA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		4 LEU A 253
PHE A 250
ILE A 215
PHE A 368
 None
 0.97A 3ko0B-4m46A:
undetectable		 3ko0B-4m46A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 LEU A  86
SER A  92
ILE A  55
CYH A  66
 None
 0.87A 3ko0B-4m9dA:
undetectable		 3ko0B-4m9dA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 LEU A 546
SER A 544
PHE A 545
ILE A 504
 None
 1.00A 3ko0B-4ot9A:
undetectable		 3ko0B-4ot9A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 361
SER A 351
PHE A 352
ILE A 390
 None
 0.78A 3ko0B-4pl0A:
undetectable		 3ko0B-4pl0A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF02940
(mRNA_triPase) 		4 LEU A  65
SER A  62
PHE A  64
ILE A 204
 None
 0.97A 3ko0B-4pn0A:
undetectable		 3ko0B-4pn0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Colwellia
psychrerythraea) 		PF02441
(Flavoprotein) 		4 LEU A  67
SER A  64
PHE A  66
ILE A  56
 None
 0.93A 3ko0B-4rheA:
undetectable		 3ko0B-4rheA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		4 LEU A 595
SER A 598
PHE A 600
ILE A 603
 None
 0.87A 3ko0B-4uzyA:
undetectable		 3ko0B-4uzyA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6q GLUCOSYLTRANSFERASE

(Streptococcus
agalactiae) 		no annotation 4 LEU A 328
SER A 326
ILE A  67
PHE A  98
 None
 0.85A 3ko0B-4w6qA:
undetectable		 3ko0B-4w6qA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
 0.69A 3ko0B-4xpzA:
undetectable		 3ko0B-4xpzA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 LEU A 136
SER A 138
PHE A 139
ILE A 188
 None
 1.00A 3ko0B-4yj1A:
undetectable		 3ko0B-4yj1A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 LEU B1002
SER B1000
PHE B 999
ILE B1116
 None
 0.95A 3ko0B-4zktB:
1.2		 3ko0B-4zktB:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 LEU A 447
SER A 454
ILE A 410
PHE A 414
 None
G  C   2 ( 4.4A)
None
A  C   4 ( 4.5A)
 0.75A 3ko0B-5bymA:
undetectable		 3ko0B-5bymA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Francisella
tularensis) 		PF00005
(ABC_tran) 		4 LEU A 387
SER A 378
PHE A 379
ILE A 416
 None
 0.86A 3ko0B-5dgxA:
undetectable		 3ko0B-5dgxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 609
SER A 606
PHE A 608
ILE A 554
 None
 0.94A 3ko0B-5dkuA:
undetectable		 3ko0B-5dkuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.23A 3ko0B-5dwzC:
undetectable		 3ko0B-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 LEU A 291
SER A 253
PHE A 252
ILE A 289
 None
 0.94A 3ko0B-5dzvA:
undetectable		 3ko0B-5dzvA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.96A 3ko0B-5gjvA:
undetectable		 3ko0B-5gjvA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyl LEGUMIN-LIKE PROTEIN

(Cicer arietinum) 		PF00190
(Cupin_1) 		4 LEU A 484
SER A 482
PHE A 483
ILE A 342
 None
 0.94A 3ko0B-5gylA:
undetectable		 3ko0B-5gylA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		4 LEU A 134
SER A 129
PHE A 130
PHE A 102
 None
 0.95A 3ko0B-5hkeA:
undetectable		 3ko0B-5hkeA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		4 LEU A 148
SER A 149
PHE A 153
ILE A 156
 None
 0.90A 3ko0B-5i2qA:
7.4		 3ko0B-5i2qA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilq ASPARTATE
CARBAMOYLTRANSFERASE

(Plasmodium
falciparum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 104
ILE A 128
CYH A 100
PHE A  99
 None
 0.95A 3ko0B-5ilqA:
undetectable		 3ko0B-5ilqA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1803
SER A1800
PHE A1802
ILE A1782
 None
 0.98A 3ko0B-5m5pA:
undetectable		 3ko0B-5m5pA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A2162
PHE A2165
ILE A2138
CYH A2142
 None
 0.68A 3ko0B-5nugA:
undetectable		 3ko0B-5nugA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		4 LEU A 761
SER A 759
PHE A 758
ILE A 738
 None
 0.90A 3ko0B-5nvrA:
undetectable		 3ko0B-5nvrA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 750
SER A 752
PHE A 753
ILE A 774
 None
 0.99A 3ko0B-5nz7A:
undetectable		 3ko0B-5nz7A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opi TAP BINDING
PROTEIN-LIKE VARIANT

(Homo sapiens) 		no annotation 4 LEU C  44
SER C  43
PHE C  77
ILE C 106
 None
 0.99A 3ko0B-5opiC:
undetectable		 3ko0B-5opiC:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pwy NUCLEAR AUTOANTIGEN
SP-100

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A 815
SER A 797
ILE A 840
PHE A 847
 None
 0.92A 3ko0B-5pwyA:
undetectable		 3ko0B-5pwyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0s MEDIATOR COMPLEX
SUBUNIT 6

(Schizosaccharomyces
pombe) 		PF04934
(Med6) 		4 LEU F  34
PHE F  37
ILE F  91
PHE F  87
 None
 0.98A 3ko0B-5u0sF:
undetectable		 3ko0B-5u0sF:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		4 LEU A 345
SER A 342
PHE A 344
ILE A  49
 None
 0.95A 3ko0B-5uldA:
undetectable		 3ko0B-5uldA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 439
ILE A 480
CYH A 494
PHE A 492
 None
 0.84A 3ko0B-5xgeA:
undetectable		 3ko0B-5xgeA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor) 		no annotation 4 LEU A 159
SER A 161
ILE A 153
PHE A 316
 None
 0.73A 3ko0B-5z0cA:
undetectable		 3ko0B-5z0cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 4 LEU A 208
SER A 205
PHE A 207
ILE A 182
 None
 0.98A 3ko0B-6bacA:
undetectable		 3ko0B-6bacA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.98A 3ko0B-6byoA:
undetectable		 3ko0B-6byoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 4 LEU A 431
SER A 433
PHE A 434
ILE A 780
 None
 0.97A 3ko0B-6d4jA:
undetectable		 3ko0B-6d4jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 4 LEU A 170
SER A 167
PHE A 169
ILE A 102
 None
 0.98A 3ko0B-6emsA:
undetectable		 3ko0B-6emsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 LEU B 102
PHE B 103
ILE B 262
PHE B 254
 None
 0.89A 3ko0B-6evjB:
undetectable		 3ko0B-6evjB:
17.92