SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_B_TFPB201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoh CELLULOSOMAL-SCAFFOL
DING PROTEIN A


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
4 ILE A  23
PHE A  27
PHE A  82
PHE A  40
None
1.03A 3ko0B-1aohA:
undetectable
3ko0J-1aohA:
undetectable
3ko0B-1aohA:
19.21
3ko0J-1aohA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus)
PF00079
(Serpin)
4 ILE A 389
PHE A 124
PHE A 107
PHE A 109
None
1.04A 3ko0B-1attA:
0.3
3ko0J-1attA:
0.3
3ko0B-1attA:
11.81
3ko0J-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus)
PF00079
(Serpin)
4 ILE A 421
PHE A 107
PHE A 109
PHE A 124
None
1.03A 3ko0B-1attA:
0.3
3ko0J-1attA:
0.3
3ko0B-1attA:
11.81
3ko0J-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens)
PF00089
(Trypsin)
4 GLY A 184
ILE A  16
PHE A  45
PHE A 228
None
1.05A 3ko0B-1au8A:
undetectable
3ko0J-1au8A:
undetectable
3ko0B-1au8A:
15.31
3ko0J-1au8A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8b SPORE PROTEASE

(Bacillus
megaterium)
PF03418
(Peptidase_A25)
4 GLY A 620
ILE A 742
MET A 745
PHE A 496
None
0.92A 3ko0B-1c8bA:
undetectable
3ko0J-1c8bA:
undetectable
3ko0B-1c8bA:
13.75
3ko0J-1c8bA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1)
PF00082
(Peptidase_S8)
4 GLY A 183
ILE A 210
MET A 222
PHE A 194
None
0.69A 3ko0B-1dbiA:
undetectable
3ko0J-1dbiA:
undetectable
3ko0B-1dbiA:
15.02
3ko0J-1dbiA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE


(Escherichia
coli)
PF00156
(Pribosyltran)
PF13522
(GATase_6)
4 ILE A 407
CYH A 252
PHE A 456
PHE A 461
None
0.93A 3ko0B-1ecgA:
0.0
3ko0J-1ecgA:
0.0
3ko0B-1ecgA:
15.00
3ko0J-1ecgA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)


(Agrobacterium
tumefaciens)
PF00561
(Abhydrolase_1)
4 GLY A  37
ILE A 219
PHE A 155
PHE A 179
None
1.03A 3ko0B-1ehyA:
0.3
3ko0J-1ehyA:
0.2
3ko0B-1ehyA:
15.52
3ko0J-1ehyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Thermotoga
maritima)
PF01380
(SIS)
4 ILE A 155
MET A 154
PHE A  19
PHE A  22
None
0.93A 3ko0B-1j5xA:
undetectable
3ko0J-1j5xA:
undetectable
3ko0B-1j5xA:
15.98
3ko0J-1j5xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
4 GLY A2825
PHE A2636
PHE A2600
PHE A2647
None
0.99A 3ko0B-1js8A:
undetectable
3ko0J-1js8A:
undetectable
3ko0B-1js8A:
13.47
3ko0J-1js8A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvg GUANYLATE KINASE

(Mus musculus)
PF00625
(Guanylate_kin)
4 GLY A 106
CYH A  98
PHE A  32
PHE A  25
5GP  A1202 (-3.2A)
None
None
None
1.05A 3ko0B-1lvgA:
0.0
3ko0J-1lvgA:
0.0
3ko0B-1lvgA:
20.83
3ko0J-1lvgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oru YUAD PROTEIN

(Bacillus
subtilis)
no annotation 4 GLY A  99
ILE A 160
PHE A  30
PHE A 114
None
0.88A 3ko0B-1oruA:
0.0
3ko0J-1oruA:
0.0
3ko0B-1oruA:
19.58
3ko0J-1oruA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q32 TYROSYL-DNA
PHOSPHODIESTERASE


(Saccharomyces
cerevisiae)
PF06087
(Tyr-DNA_phospho)
4 GLY A 110
ILE A 103
CYH A 216
PHE A 204
None
1.05A 3ko0B-1q32A:
undetectable
3ko0J-1q32A:
undetectable
3ko0B-1q32A:
12.47
3ko0J-1q32A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA


(Paracoccus
denitrificans)
PF00115
(COX1)
4 GLY A  95
ILE A 282
PHE A 422
PHE A 425
HEA  A 601 ( 4.0A)
HEA  A 602 ( 4.7A)
None
None
1.03A 3ko0B-1qleA:
undetectable
3ko0J-1qleA:
undetectable
3ko0B-1qleA:
10.65
3ko0J-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE


(Homo sapiens)
PF00270
(DEAD)
4 GLY A  46
ILE A  80
PHE A  99
PHE A 227
None
0.99A 3ko0B-1t6nA:
undetectable
3ko0J-1t6nA:
0.0
3ko0B-1t6nA:
18.18
3ko0J-1t6nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans)
PF13277
(YmdB)
4 GLY A 187
ILE A 170
PHE A  31
PHE A 239
None
1.05A 3ko0B-1t70A:
undetectable
3ko0J-1t70A:
undetectable
3ko0B-1t70A:
15.94
3ko0J-1t70A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5l PRION PROTEIN

(Trachemys
scripta)
PF00377
(Prion)
4 GLY A 123
ILE A 210
MET A 213
CYH A 214
None
0.77A 3ko0B-1u5lA:
undetectable
3ko0J-1u5lA:
0.4
3ko0B-1u5lA:
18.75
3ko0J-1u5lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5l PRION PROTEIN

(Trachemys
scripta)
PF00377
(Prion)
4 GLY A 124
ILE A 210
MET A 213
CYH A 214
None
0.85A 3ko0B-1u5lA:
undetectable
3ko0J-1u5lA:
0.4
3ko0B-1u5lA:
18.75
3ko0J-1u5lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY


(Thermotoga
maritima)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 ILE A 255
PHE A  81
PHE A 287
PHE A 282
None
0.89A 3ko0B-1vmaA:
2.5
3ko0J-1vmaA:
2.6
3ko0B-1vmaA:
14.05
3ko0J-1vmaA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN


(Saccharomyces
cerevisiae)
PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd)
4 GLY A 424
ILE A 694
PHE A 540
PHE A 662
None
0.91A 3ko0B-1z45A:
undetectable
3ko0J-1z45A:
undetectable
3ko0B-1z45A:
9.59
3ko0J-1z45A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae8 IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE


(Staphylococcus
aureus)
PF00475
(IGPD)
4 GLY A  73
ILE A  51
PHE A 127
PHE A 135
None
0.84A 3ko0B-2ae8A:
undetectable
3ko0J-2ae8A:
1.4
3ko0B-2ae8A:
14.68
3ko0J-2ae8A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE


(Thermotoga
maritima)
PF00294
(PfkB)
4 GLY A  32
ILE A 110
PHE A 132
PHE A 130
None
1.04A 3ko0B-2afbA:
undetectable
3ko0J-2afbA:
0.0
3ko0B-2afbA:
16.99
3ko0J-2afbA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens)
PF00079
(Serpin)
4 GLY I 339
PHE I 123
PHE I 106
PHE I 108
None
0.93A 3ko0B-2b4xI:
undetectable
3ko0J-2b4xI:
0.0
3ko0B-2b4xI:
15.12
3ko0J-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens)
PF00079
(Serpin)
4 ILE I 420
PHE I 106
PHE I 108
PHE I 123
None
0.88A 3ko0B-2b4xI:
undetectable
3ko0J-2b4xI:
0.0
3ko0B-2b4xI:
15.12
3ko0J-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
4 GLY A 308
ILE A 288
MET A 253
PHE A 331
None
0.95A 3ko0B-2bfwA:
undetectable
3ko0J-2bfwA:
undetectable
3ko0B-2bfwA:
19.00
3ko0J-2bfwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgs ALDOSE REDUCTASE

(Hordeum vulgare)
PF00248
(Aldo_ket_red)
4 GLY A 146
ILE A  89
PHE A 301
PHE A 142
None
1.01A 3ko0B-2bgsA:
undetectable
3ko0J-2bgsA:
undetectable
3ko0B-2bgsA:
14.50
3ko0J-2bgsA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
4 ILE A  23
PHE A  27
PHE A  82
PHE A  40
None
0.95A 3ko0B-2cclA:
undetectable
3ko0J-2cclA:
undetectable
3ko0B-2cclA:
20.13
3ko0J-2cclA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6


(Homo sapiens)
PF00025
(Arf)
4 GLY A 167
ILE A  34
CYH A  22
PHE A  92
None
1.01A 3ko0B-2h57A:
0.0
3ko0J-2h57A:
undetectable
3ko0B-2h57A:
18.65
3ko0J-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE


(Xanthomonas
campestris)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLY A 356
ILE A 419
PHE A 429
PHE A  14
None
1.04A 3ko0B-2hneA:
undetectable
3ko0J-2hneA:
undetectable
3ko0B-2hneA:
13.63
3ko0J-2hneA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR


(Burkholderia
pseudomallei)
PF07487
(SopE_GEF)
4 GLY A 171
MET A 132
CYH A 131
PHE A 130
None
0.96A 3ko0B-2jokA:
0.0
3ko0J-2jokA:
undetectable
3ko0B-2jokA:
17.20
3ko0J-2jokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1


(Thermotoga
maritima)
PF00749
(tRNA-synt_1c)
4 ILE A 330
PHE A 379
PHE A 371
PHE A 341
None
0.88A 3ko0B-2o5rA:
undetectable
3ko0J-2o5rA:
undetectable
3ko0B-2o5rA:
12.33
3ko0J-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1


(Thermotoga
maritima)
PF00749
(tRNA-synt_1c)
4 PHE A 378
PHE A 379
PHE A 371
PHE A 341
None
1.03A 3ko0B-2o5rA:
undetectable
3ko0J-2o5rA:
undetectable
3ko0B-2o5rA:
12.33
3ko0J-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I


(Escherichia
coli)
PF00365
(PFK)
4 GLY A 101
ILE A 296
PHE A 117
PHE A  76
None
0.95A 3ko0B-2pfkA:
undetectable
3ko0J-2pfkA:
undetectable
3ko0B-2pfkA:
14.20
3ko0J-2pfkA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE


(Pyrococcus
furiosus)
PF00722
(Glyco_hydro_16)
4 GLY A 190
ILE A 228
PHE A 131
PHE A 258
None
1.05A 3ko0B-2vy0A:
undetectable
3ko0J-2vy0A:
undetectable
3ko0B-2vy0A:
17.32
3ko0J-2vy0A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB


(Salmonella
enterica)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
4 GLY A  47
ILE A 370
PHE A  71
PHE A  76
None
0.93A 3ko0B-2wnwA:
undetectable
3ko0J-2wnwA:
undetectable
3ko0B-2wnwA:
12.09
3ko0J-2wnwA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xty QNRB1

(Klebsiella
pneumoniae)
PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4)
4 GLY A  93
ILE A 116
PHE A 171
PHE A 164
None
0.97A 3ko0B-2xtyA:
undetectable
3ko0J-2xtyA:
undetectable
3ko0B-2xtyA:
21.21
3ko0J-2xtyA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 GLY O 365
ILE O 316
PHE O 341
PHE O 337
None
1.04A 3ko0B-2zf5O:
undetectable
3ko0J-2zf5O:
undetectable
3ko0B-2zf5O:
11.90
3ko0J-2zf5O:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7x FK506-BINDING
PROTEIN 6


(Homo sapiens)
PF00254
(FKBP_C)
4 GLY A 105
ILE A  43
PHE A 135
PHE A 112
None
1.03A 3ko0B-3b7xA:
undetectable
3ko0J-3b7xA:
undetectable
3ko0B-3b7xA:
20.53
3ko0J-3b7xA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2


(Rattus
norvegicus)
PF01150
(GDA1_CD39)
5 GLY A 203
ILE A 209
PHE A 420
PHE A 348
PHE A 425
None
1.43A 3ko0B-3cj1A:
0.7
3ko0J-3cj1A:
undetectable
3ko0B-3cj1A:
11.67
3ko0J-3cj1A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euw MYO-INOSITOL
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 GLY A 111
ILE A  96
CYH A  92
PHE A 291
None
1.00A 3ko0B-3euwA:
undetectable
3ko0J-3euwA:
undetectable
3ko0B-3euwA:
11.92
3ko0J-3euwA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE


(Salmonella
enterica)
PF01238
(PMI_typeI)
4 ILE A 335
PHE A 344
PHE A  85
PHE A 323
None
0.80A 3ko0B-3h1wA:
undetectable
3ko0J-3h1wA:
undetectable
3ko0B-3h1wA:
12.28
3ko0J-3h1wA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn5 PUTATIVE EXPORTED
PROTEIN BF0290


(Bacteroides
fragilis)
PF12866
(DUF3823)
4 GLY A 149
ILE A 227
CYH A 217
PHE A 192
None
0.84A 3ko0B-3hn5A:
undetectable
3ko0J-3hn5A:
undetectable
3ko0B-3hn5A:
12.96
3ko0J-3hn5A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im0 VAL-1

(Paramecium
bursaria
Chlorella virus
CVK2)
no annotation 4 ILE A 117
PHE A  61
PHE A 235
PHE A  59
None
0.97A 3ko0B-3im0A:
undetectable
3ko0J-3im0A:
undetectable
3ko0B-3im0A:
17.36
3ko0J-3im0A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2


(Dichelobacter
nodosus)
PF00082
(Peptidase_S8)
4 GLY A 227
ILE A 254
MET A 273
PHE A 238
None
0.76A 3ko0B-3lpdA:
undetectable
3ko0J-3lpdA:
undetectable
3ko0B-3lpdA:
12.68
3ko0J-3lpdA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
4 GLY A1384
ILE A1341
PHE A1374
PHE A1332
None
0.94A 3ko0B-3mmpA:
undetectable
3ko0J-3mmpA:
undetectable
3ko0B-3mmpA:
9.19
3ko0J-3mmpA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE


(Cytophaga
hutchinsonii)
PF01494
(FAD_binding_3)
4 GLY A 358
ILE A 303
PHE A 231
PHE A 238
None
0.87A 3ko0B-3nixA:
undetectable
3ko0J-3nixA:
undetectable
3ko0B-3nixA:
14.32
3ko0J-3nixA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE


(Zymomonas
mobilis)
PF05096
(Glu_cyclase_2)
4 GLY A 212
ILE A 208
PHE A 240
PHE A  48
None
1.04A 3ko0B-3nomA:
undetectable
3ko0J-3nomA:
undetectable
3ko0B-3nomA:
16.03
3ko0J-3nomA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuz PUTATIVE ACETYL
XYLAN ESTERASE


(Bacteroides
fragilis)
PF12715
(Abhydrolase_7)
4 GLY A 336
ILE A 331
PHE A 178
PHE A 400
None
0.94A 3ko0B-3nuzA:
undetectable
3ko0J-3nuzA:
undetectable
3ko0B-3nuzA:
14.12
3ko0J-3nuzA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opn PUTATIVE HEMOLYSIN

(Lactococcus
lactis)
PF01728
(FtsJ)
4 GLY A 150
ILE A 128
PHE A 108
PHE A 118
None
1.02A 3ko0B-3opnA:
undetectable
3ko0J-3opnA:
undetectable
3ko0B-3opnA:
16.38
3ko0J-3opnA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydomonas
reinhardtii)
PF00155
(Aminotran_1_2)
4 GLY A 438
ILE A 393
PHE A 414
PHE A 366
None
0.96A 3ko0B-3qguA:
undetectable
3ko0J-3qguA:
undetectable
3ko0B-3qguA:
12.44
3ko0J-3qguA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M


(Escherichia
coli)
no annotation 4 GLY L 145
PHE L 183
PHE L 186
PHE M 408
None
0.99A 3ko0B-3rkoL:
undetectable
3ko0J-3rkoL:
undetectable
3ko0B-3rkoL:
8.96
3ko0J-3rkoL:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp2 RAT MAST CELL
PROTEASE II


(Rattus rattus)
PF00089
(Trypsin)
4 GLY A 184
ILE A  16
PHE A  45
PHE A 228
None
1.04A 3ko0B-3rp2A:
undetectable
3ko0J-3rp2A:
undetectable
3ko0B-3rp2A:
21.89
3ko0J-3rp2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1


(Saccharomyces
cerevisiae)
PF01399
(PCI)
4 CYH B  65
PHE B  68
PHE B  90
PHE B  16
None
0.90A 3ko0B-3t5vB:
undetectable
3ko0J-3t5vB:
undetectable
3ko0B-3t5vB:
13.08
3ko0J-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdo MFS TRANSPORTER

(Escherichia
coli)
PF07690
(MFS_1)
4 GLY A  69
ILE A 327
PHE A 144
PHE A  21
None
0.92A 3ko0B-3wdoA:
undetectable
3ko0J-3wdoA:
undetectable
3ko0B-3wdoA:
12.92
3ko0J-3wdoA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2


(Homo sapiens)
PF03006
(HlyIII)
4 GLY A 229
ILE A 258
PHE A 269
PHE A 282
None
1.04A 3ko0B-3wxwA:
1.3
3ko0J-3wxwA:
1.4
3ko0B-3wxwA:
18.22
3ko0J-3wxwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B


(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110)
4 GLY A  47
ILE A 112
PHE A 135
PHE A 144
None
0.82A 3ko0B-4b9yA:
undetectable
3ko0J-4b9yA:
undetectable
3ko0B-4b9yA:
7.71
3ko0J-4b9yA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 4 ILE A 353
PHE A 366
PHE A 291
PHE A 193
None
1.04A 3ko0B-4btpA:
1.6
3ko0J-4btpA:
1.5
3ko0B-4btpA:
9.18
3ko0J-4btpA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0o A-KINASE ANCHOR
PROTEIN 13


(Homo sapiens)
PF00621
(RhoGEF)
4 GLY A2027
ILE A2019
CYH A2146
PHE A2104
None
1.04A 3ko0B-4d0oA:
1.0
3ko0J-4d0oA:
0.9
3ko0B-4d0oA:
19.42
3ko0J-4d0oA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dw1 P2X PURINOCEPTOR

(Danio rerio)
PF00864
(P2X_receptor)
4 GLY A 254
PHE A 233
PHE A 322
PHE A 102
None
0.96A 3ko0B-4dw1A:
undetectable
3ko0J-4dw1A:
undetectable
3ko0B-4dw1A:
13.78
3ko0J-4dw1A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egw MAGNESIUM TRANSPORT
PROTEIN CORA


(Methanocaldococcus
jannaschii)
PF01544
(CorA)
4 GLY A  93
ILE A 208
PHE A 134
PHE A 128
None
None
None
BU1  A 319 (-3.7A)
0.90A 3ko0B-4egwA:
undetectable
3ko0J-4egwA:
undetectable
3ko0B-4egwA:
15.00
3ko0J-4egwA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462


(Clostridium
acetobutylicum)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
4 GLY A 329
ILE A 317
PHE A 135
PHE A 214
None
0.83A 3ko0B-4eufA:
undetectable
3ko0J-4eufA:
undetectable
3ko0B-4eufA:
13.46
3ko0J-4eufA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fch OUTER MEMBRANE
PROTEIN SUSE


(Bacteroides
thetaiotaomicron)
PF16411
(SusF_SusE)
4 GLY A 289
PHE A 314
PHE A 379
PHE A 340
None
0.96A 3ko0B-4fchA:
undetectable
3ko0J-4fchA:
undetectable
3ko0B-4fchA:
15.07
3ko0J-4fchA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE


(Bacteroides
thetaiotaomicron)
PF16411
(SusF_SusE)
4 GLY A 289
PHE A 314
PHE A 379
PHE A 340
None
0.95A 3ko0B-4femA:
undetectable
3ko0J-4femA:
undetectable
3ko0B-4femA:
15.73
3ko0J-4femA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE


(Escherichia
coli;
Escherichia
virus Qbeta)
PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B)
4 GLY A 669
ILE A 626
PHE A 659
PHE A 617
None
0.88A 3ko0B-4fwtA:
undetectable
3ko0J-4fwtA:
undetectable
3ko0B-4fwtA:
6.15
3ko0J-4fwtA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR


(Homo sapiens)
PF00079
(Serpin)
4 GLY A 292
PHE A  70
PHE A  58
PHE A  60
None
1.01A 3ko0B-4ga7A:
undetectable
3ko0J-4ga7A:
undetectable
3ko0B-4ga7A:
14.47
3ko0J-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
4 GLY L 508
ILE L 294
PHE L 532
PHE L 524
None
0.85A 3ko0B-4heaL:
0.5
3ko0J-4heaL:
undetectable
3ko0B-4heaL:
10.77
3ko0J-4heaL:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j75 TRYPTOPHANYL-TRNA
SYNTHETASE


(Plasmodium
falciparum)
PF00579
(tRNA-synt_1b)
4 ILE A 430
CYH A 433
PHE A 438
PHE A 383
None
0.96A 3ko0B-4j75A:
undetectable
3ko0J-4j75A:
undetectable
3ko0B-4j75A:
14.44
3ko0J-4j75A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j75 TRYPTOPHANYL-TRNA
SYNTHETASE


(Plasmodium
falciparum)
PF00579
(tRNA-synt_1b)
4 ILE A 430
PHE A 350
PHE A 412
PHE A 414
None
1.02A 3ko0B-4j75A:
undetectable
3ko0J-4j75A:
undetectable
3ko0B-4j75A:
14.44
3ko0J-4j75A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2k TANKYRASE-2

(Homo sapiens)
PF00644
(PARP)
4 GLY A1058
ILE A1039
PHE A1098
PHE A1061
None
1.05A 3ko0B-4l2kA:
undetectable
3ko0J-4l2kA:
undetectable
3ko0B-4l2kA:
16.75
3ko0J-4l2kA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 GLY G 118
ILE D  49
PHE D  38
PHE D 109
None
0.86A 3ko0B-4lhuG:
undetectable
3ko0J-4lhuG:
undetectable
3ko0B-4lhuG:
18.43
3ko0J-4lhuG:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oa7 TANKYRASE-1

(Homo sapiens)
PF00644
(PARP)
4 GLY A1211
ILE A1192
PHE A1251
PHE A1214
None
2XS  A1402 ( 4.7A)
None
None
1.03A 3ko0B-4oa7A:
undetectable
3ko0J-4oa7A:
undetectable
3ko0B-4oa7A:
19.81
3ko0J-4oa7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18


(Serratia
proteamaculans)
PF00704
(Glyco_hydro_18)
4 GLY A 195
ILE A 210
PHE A 132
PHE A 119
None
0.71A 3ko0B-4q22A:
undetectable
3ko0J-4q22A:
undetectable
3ko0B-4q22A:
13.23
3ko0J-4q22A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m)
4 ILE A 433
PHE A 386
PHE A 406
PHE A 437
None
0.97A 3ko0B-4q6pA:
undetectable
3ko0J-4q6pA:
undetectable
3ko0B-4q6pA:
13.56
3ko0J-4q6pA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18


(Pseudomonas
protegens)
PF00704
(Glyco_hydro_18)
4 GLY A 259
ILE A 178
PHE A 148
PHE A 159
None
1.00A 3ko0B-4q6tA:
undetectable
3ko0J-4q6tA:
undetectable
3ko0B-4q6tA:
13.24
3ko0J-4q6tA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Ochrobactrum
anthropi)
PF01547
(SBP_bac_1)
4 GLY A 225
ILE A 392
PHE A 400
PHE A 233
None
0.80A 3ko0B-4r2bA:
0.4
3ko0J-4r2bA:
0.4
3ko0B-4r2bA:
15.68
3ko0J-4r2bA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA


(Homo sapiens)
PF09240
(IL6Ra-bind)
4 GLY B 158
ILE B 135
PHE B 105
PHE B 187
None
0.67A 3ko0B-4rs1B:
undetectable
3ko0J-4rs1B:
undetectable
3ko0B-4rs1B:
18.62
3ko0J-4rs1B:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL


(Clostridium
perfringens)
PF00936
(BMC)
4 GLY A  71
ILE A   6
PHE A 203
PHE A 184
None
0.81A 3ko0B-4tlhA:
undetectable
3ko0J-4tlhA:
undetectable
3ko0B-4tlhA:
17.54
3ko0J-4tlhA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2


(Pyrococcus
furiosus)
PF12469
(DUF3692)
4 GLY A 847
ILE A 807
PHE A 791
PHE A 858
None
1.03A 3ko0B-4w8yA:
1.0
3ko0J-4w8yA:
undetectable
3ko0B-4w8yA:
9.05
3ko0J-4w8yA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB


(Drosophila
melanogaster)
PF10613
(Lig_chan-Glu_bd)
4 GLY A 222
ILE A 120
PHE A 177
PHE A 154
None
1.00A 3ko0B-4wxjA:
undetectable
3ko0J-4wxjA:
undetectable
3ko0B-4wxjA:
18.46
3ko0J-4wxjA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN


(Mycolicibacterium
thermoresistibile)
PF00722
(Glyco_hydro_16)
4 GLY A 192
PHE A 147
PHE A 195
PHE A 206
None
0.93A 3ko0B-4xdqA:
undetectable
3ko0J-4xdqA:
undetectable
3ko0B-4xdqA:
14.87
3ko0J-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN


(Homo sapiens)
PF00955
(HCO3_cotransp)
4 GLY A 714
ILE A 487
PHE A 478
PHE A 471
None
0.76A 3ko0B-4yzfA:
undetectable
3ko0J-4yzfA:
undetectable
3ko0B-4yzfA:
8.35
3ko0J-4yzfA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae)
PF12146
(Hydrolase_4)
4 GLY A 258
ILE A 233
CYH A 134
PHE A  96
None
0.97A 3ko0B-4zwnA:
undetectable
3ko0J-4zwnA:
undetectable
3ko0B-4zwnA:
14.98
3ko0J-4zwnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGJ
YBGK


(Escherichia
coli)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
4 GLY A 253
ILE B   9
CYH A 260
PHE A 193
None
0.75A 3ko0B-5dudA:
undetectable
3ko0J-5dudA:
undetectable
3ko0B-5dudA:
16.39
3ko0J-5dudA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGJ
YBGK


(Escherichia
coli)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
4 GLY A 254
ILE B   9
CYH A 260
PHE A 193
None
1.02A 3ko0B-5dudA:
undetectable
3ko0J-5dudA:
undetectable
3ko0B-5dudA:
16.39
3ko0J-5dudA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens)
PF00079
(Serpin)
4 GLY A 327
PHE A 116
PHE A 102
PHE A 104
None
0.91A 3ko0B-5ei0A:
undetectable
3ko0J-5ei0A:
undetectable
3ko0B-5ei0A:
13.45
3ko0J-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5r HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL


(Homo sapiens)
PF13589
(HATPase_c_3)
4 GLY A 162
ILE A 241
PHE A 209
PHE A 205
ANP  A 300 ( 4.5A)
None
None
None
0.87A 3ko0B-5f5rA:
undetectable
3ko0J-5f5rA:
undetectable
3ko0B-5f5rA:
18.22
3ko0J-5f5rA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
4 GLY B 740
ILE B 754
PHE B 670
PHE B 657
None
0.83A 3ko0B-5gztB:
undetectable
3ko0J-5gztB:
undetectable
3ko0B-5gztB:
6.27
3ko0J-5gztB:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
4 GLY A 740
ILE A 754
PHE A 670
PHE A 657
None
0.81A 3ko0B-5gzuA:
undetectable
3ko0J-5gzuA:
undetectable
3ko0B-5gzuA:
7.23
3ko0J-5gzuA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN


(Enterococcus
faecalis)
no annotation 4 GLY A 445
ILE A 441
PHE A 367
PHE A 397
None
1.06A 3ko0B-5h29A:
undetectable
3ko0J-5h29A:
undetectable
3ko0B-5h29A:
22.12
3ko0J-5h29A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL


(Homo sapiens)
PF00183
(HSP90)
PF13589
(HATPase_c_3)
4 GLY A 162
ILE A 241
PHE A 209
PHE A 205
ANP  A 801 ( 4.3A)
None
None
None
0.97A 3ko0B-5hphA:
undetectable
3ko0J-5hphA:
undetectable
3ko0B-5hphA:
11.24
3ko0J-5hphA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN


(Stenotrophomonas
maltophilia)
PF12849
(PBP_like_2)
4 ILE A 140
PHE A 192
PHE A 121
PHE A 188
None
0.98A 3ko0B-5j1dA:
undetectable
3ko0J-5j1dA:
undetectable
3ko0B-5j1dA:
14.48
3ko0J-5j1dA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M)
4 GLY A 678
ILE A 567
PHE A 564
PHE A 656
None
0.91A 3ko0B-5l46A:
undetectable
3ko0J-5l46A:
undetectable
3ko0B-5l46A:
9.00
3ko0J-5l46A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT


(Clostridioides
difficile)
no annotation 4 GLY B 253
ILE A 270
CYH A 272
PHE A 302
None
0.88A 3ko0B-5ol2B:
undetectable
3ko0J-5ol2B:
undetectable
3ko0B-5ol2B:
18.60
3ko0J-5ol2B:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oup PERFORIN-LIKE
PROTEIN 1


(Toxoplasma
gondii)
no annotation 4 GLY A 478
ILE A 737
PHE A 670
PHE A 767
None
0.92A 3ko0B-5oupA:
undetectable
3ko0J-5oupA:
undetectable
3ko0B-5oupA:
14.85
3ko0J-5oupA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae)
no annotation 4 GLY B 298
PHE B 314
PHE B 301
PHE B 332
None
0.95A 3ko0B-5swiB:
undetectable
3ko0J-5swiB:
undetectable
3ko0B-5swiB:
10.84
3ko0J-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
no annotation 4 GLY A 193
CYH A 243
PHE A 264
PHE A 274
None
0.97A 3ko0B-5ta1A:
undetectable
3ko0J-5ta1A:
undetectable
3ko0B-5ta1A:
9.09
3ko0J-5ta1A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6acd -

(-)
no annotation 4 GLY A1026
PHE A 782
PHE A 784
PHE A1034
None
1.02A 3ko0B-6acdA:
1.2
3ko0J-6acdA:
1.2
3ko0B-6acdA:
undetectable
3ko0J-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1


(Homo sapiens)
no annotation 4 GLY A 120
ILE A 166
PHE A 200
PHE A 181
None
0.87A 3ko0B-6b3xA:
undetectable
3ko0J-6b3xA:
undetectable
3ko0B-6b3xA:
14.37
3ko0J-6b3xA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5x SUPPRESSOR OF
CYTOKINE SIGNALLING
1


(Xenopus laevis)
no annotation 4 GLY D  99
PHE D 209
PHE D 207
PHE D  79
None
0.73A 3ko0B-6c5xD:
undetectable
3ko0J-6c5xD:
undetectable
3ko0B-6c5xD:
21.78
3ko0J-6c5xD:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT


(Methylomicrobium
alcaliphilum)
no annotation 4 GLY B 185
ILE A  91
MET A 141
PHE A  88
None
0.82A 3ko0B-6cxhB:
undetectable
3ko0J-6cxhB:
1.1
3ko0B-6cxhB:
20.75
3ko0J-6cxhB:
20.75