SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_A_TFPA202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 LEU A 142
PHE A  86
ILE A  18
ASP A 145
SER A 130
 None
 1.20A 3ko0A-1ag9A:
undetectable
3ko0B-1ag9A:
undetectable
3ko0C-1ag9A:
undetectable
3ko0D-1ag9A:
undetectable		 3ko0A-1ag9A:
22.70
3ko0B-1ag9A:
22.70
3ko0C-1ag9A:
22.70
3ko0D-1ag9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czk FLAVODOXIN

(Synechococcus
elongatus) 		PF00258
(Flavodoxin_1) 		5 LEU A 141
PHE A  86
ILE A  17
ASP A 144
SER A 130
 None
 1.19A 3ko0A-1czkA:
undetectable
3ko0B-1czkA:
undetectable
3ko0C-1czkA:
undetectable
3ko0D-1czkA:
undetectable		 3ko0A-1czkA:
21.02
3ko0B-1czkA:
21.02
3ko0C-1czkA:
21.02
3ko0D-1czkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 GLU A 137
LEU A 136
ASP A 180
ASP A  92
SER A  99
 None
 1.18A 3ko0A-1dysA:
undetectable
3ko0B-1dysA:
0.0
3ko0C-1dysA:
undetectable
3ko0D-1dysA:
undetectable		 3ko0A-1dysA:
10.63
3ko0B-1dysA:
10.63
3ko0C-1dysA:
10.63
3ko0D-1dysA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		5 LEU A 174
LEU A 176
ASP A 177
ASP A  47
SER A  84
 None
None
PMM  A 301 (-3.1A)
None
None
 1.27A 3ko0A-1eyeA:
undetectable
3ko0B-1eyeA:
undetectable
3ko0C-1eyeA:
undetectable
3ko0D-1eyeA:
undetectable		 3ko0A-1eyeA:
12.10
3ko0B-1eyeA:
12.10
3ko0C-1eyeA:
12.10
3ko0D-1eyeA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		5 LEU A  82
PHE A  81
CYH A  99
LEU A 125
ASP A 116
 None
None
NAD  A1382 (-4.5A)
None
None
 1.13A 3ko0A-1gy8A:
undetectable
3ko0B-1gy8A:
undetectable
3ko0C-1gy8A:
undetectable
3ko0D-1gy8A:
undetectable		 3ko0A-1gy8A:
13.92
3ko0B-1gy8A:
13.92
3ko0C-1gy8A:
13.92
3ko0D-1gy8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn1 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Haemophilus
influenzae) 		PF02542
(YgbB) 		5 LEU A 121
PHE A  82
ILE A  49
LEU A  45
ASP A  73
 None
 1.22A 3ko0A-1jn1A:
undetectable
3ko0B-1jn1A:
undetectable
3ko0C-1jn1A:
undetectable
3ko0D-1jn1A:
undetectable		 3ko0A-1jn1A:
20.67
3ko0B-1jn1A:
20.67
3ko0C-1jn1A:
20.67
3ko0D-1jn1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 LEU L 408
PHE L 502
ILE L 211
PHE L 497
LEU L 472
 None
 1.23A 3ko0A-1kfuL:
6.6
3ko0B-1kfuL:
6.7
3ko0C-1kfuL:
3.8
3ko0D-1kfuL:
3.7		 3ko0A-1kfuL:
11.01
3ko0B-1kfuL:
11.01
3ko0C-1kfuL:
11.01
3ko0D-1kfuL:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		5 ILE A 280
CYH A 263
LEU A 259
PHE A  64
SER A  16
 None
 1.26A 3ko0A-1luaA:
undetectable
3ko0B-1luaA:
0.0
3ko0C-1luaA:
undetectable
3ko0D-1luaA:
undetectable		 3ko0A-1luaA:
15.25
3ko0B-1luaA:
15.25
3ko0C-1luaA:
15.25
3ko0D-1luaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN

(Schizosaccharomyces
pombe) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 LEU A 110
PHE A 109
GLU A 150
LEU A 151
ASP A 149
 None
 1.14A 3ko0A-1ni3A:
undetectable
3ko0B-1ni3A:
undetectable
3ko0C-1ni3A:
undetectable
3ko0D-1ni3A:
undetectable		 3ko0A-1ni3A:
12.47
3ko0B-1ni3A:
12.47
3ko0C-1ni3A:
12.47
3ko0D-1ni3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 LEU A 436
SER A 486
ILE A 423
ASP A 439
ASP A 482
 None
 1.16A 3ko0A-1pz3A:
undetectable
3ko0B-1pz3A:
undetectable
3ko0C-1pz3A:
undetectable
3ko0D-1pz3A:
undetectable		 3ko0A-1pz3A:
12.17
3ko0B-1pz3A:
12.17
3ko0C-1pz3A:
12.17
3ko0D-1pz3A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A 296
SER A 297
PHE A 301
ILE A 304
LEU A 325
 None
 1.15A 3ko0A-1pztA:
undetectable
3ko0B-1pztA:
undetectable
3ko0C-1pztA:
undetectable
3ko0D-1pztA:
undetectable		 3ko0A-1pztA:
17.80
3ko0B-1pztA:
17.80
3ko0C-1pztA:
17.80
3ko0D-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A  32
PHE A  29
ILE A 108
LEU A  64
ASP A  24
 None
 1.23A 3ko0A-1q3bA:
1.4
3ko0B-1q3bA:
1.5
3ko0C-1q3bA:
undetectable
3ko0D-1q3bA:
1.3		 3ko0A-1q3bA:
17.05
3ko0B-1q3bA:
17.05
3ko0C-1q3bA:
17.05
3ko0D-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 LEU A 243
LEU A 110
ASP A 111
ASP A 277
SER A 280
 None
 0.99A 3ko0A-1vp4A:
undetectable
3ko0B-1vp4A:
0.0
3ko0C-1vp4A:
undetectable
3ko0D-1vp4A:
undetectable		 3ko0A-1vp4A:
13.44
3ko0B-1vp4A:
13.44
3ko0C-1vp4A:
13.44
3ko0D-1vp4A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 285
SER A 266
ILE A 301
PHE A 224
LEU A 303
 None
 1.16A 3ko0A-1x9eA:
undetectable
3ko0B-1x9eA:
0.0
3ko0C-1x9eA:
undetectable
3ko0D-1x9eA:
undetectable		 3ko0A-1x9eA:
14.44
3ko0B-1x9eA:
14.44
3ko0C-1x9eA:
14.44
3ko0D-1x9eA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 LEU A 129
ILE A  82
ASP A 121
PHE A 140
SER A 135
 None
 1.27A 3ko0A-1ybiA:
undetectable
3ko0B-1ybiA:
undetectable
3ko0C-1ybiA:
undetectable
3ko0D-1ybiA:
undetectable		 3ko0A-1ybiA:
14.58
3ko0B-1ybiA:
14.58
3ko0C-1ybiA:
14.58
3ko0D-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 LEU A  25
SER A  24
ILE A  36
CYH A  10
ASP A  13
 None
 1.15A 3ko0A-1zzmA:
undetectable
3ko0B-1zzmA:
0.0
3ko0C-1zzmA:
undetectable
3ko0D-1zzmA:
undetectable		 3ko0A-1zzmA:
14.89
3ko0B-1zzmA:
14.89
3ko0C-1zzmA:
14.89
3ko0D-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ILE A 139
GLU A 148
LEU A 136
ASP A 162
SER A 202
 None
 1.25A 3ko0A-2a9fA:
undetectable
3ko0B-2a9fA:
0.1
3ko0C-2a9fA:
undetectable
3ko0D-2a9fA:
undetectable		 3ko0A-2a9fA:
15.98
3ko0B-2a9fA:
15.98
3ko0C-2a9fA:
15.98
3ko0D-2a9fA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 SER A 154
PHE A 156
ILE A 331
LEU A 151
SER A 186
 None
 1.23A 3ko0A-2c4kA:
undetectable
3ko0B-2c4kA:
undetectable
3ko0C-2c4kA:
undetectable
3ko0D-2c4kA:
undetectable		 3ko0A-2c4kA:
12.83
3ko0B-2c4kA:
12.83
3ko0C-2c4kA:
12.83
3ko0D-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 LEU A 175
ILE A  55
PHE A   7
LEU A  59
SER A 168
 None
 1.18A 3ko0A-2e0iA:
undetectable
3ko0B-2e0iA:
0.0
3ko0C-2e0iA:
undetectable
3ko0D-2e0iA:
undetectable		 3ko0A-2e0iA:
12.59
3ko0B-2e0iA:
12.59
3ko0C-2e0iA:
12.59
3ko0D-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 LEU A 130
SER A 128
PHE A 129
ILE A 317
LEU A 288
 None
 0.95A 3ko0A-2fqxA:
undetectable
3ko0B-2fqxA:
undetectable
3ko0C-2fqxA:
undetectable
3ko0D-2fqxA:
undetectable		 3ko0A-2fqxA:
13.92
3ko0B-2fqxA:
13.92
3ko0C-2fqxA:
13.92
3ko0D-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 LEU A 156
SER A 157
ILE A 164
GLU A 160
LEU A 134
 None
 1.22A 3ko0A-2ghiA:
undetectable
3ko0B-2ghiA:
undetectable
3ko0C-2ghiA:
undetectable
3ko0D-2ghiA:
undetectable		 3ko0A-2ghiA:
17.14
3ko0B-2ghiA:
17.14
3ko0C-2ghiA:
17.14
3ko0D-2ghiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 SER A 166
PHE A 168
ILE A 344
LEU A 163
SER A 198
 CL  A1369 (-3.8A)
None
None
None
None
 1.27A 3ko0A-2ji4A:
undetectable
3ko0B-2ji4A:
undetectable
3ko0C-2ji4A:
undetectable
3ko0D-2ji4A:
undetectable		 3ko0A-2ji4A:
14.12
3ko0B-2ji4A:
14.12
3ko0C-2ji4A:
14.12
3ko0D-2ji4A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 910
PHE A 909
ILE A 888
CYH A 892
LEU A 845
 None
 0.97A 3ko0A-2ogvA:
undetectable
3ko0B-2ogvA:
undetectable
3ko0C-2ogvA:
undetectable
3ko0D-2ogvA:
undetectable		 3ko0A-2ogvA:
15.41
3ko0B-2ogvA:
15.41
3ko0C-2ogvA:
15.41
3ko0D-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20

(Homo sapiens) 		PF00270
(DEAD) 		5 PHE A  82
ILE A 153
LEU A 121
ASP A 122
PHE A  64
 ADP  A 300 (-4.4A)
None
None
None
None
 1.27A 3ko0A-2oxcA:
undetectable
3ko0B-2oxcA:
undetectable
3ko0C-2oxcA:
undetectable
3ko0D-2oxcA:
undetectable		 3ko0A-2oxcA:
19.37
3ko0B-2oxcA:
19.37
3ko0C-2oxcA:
19.37
3ko0D-2oxcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 LEU A  82
SER A  84
PHE A  86
LEU A 117
ASP A 257
 None
 1.22A 3ko0A-2q83A:
undetectable
3ko0B-2q83A:
undetectable
3ko0C-2q83A:
undetectable
3ko0D-2q83A:
undetectable		 3ko0A-2q83A:
15.38
3ko0B-2q83A:
15.38
3ko0C-2q83A:
15.38
3ko0D-2q83A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 SER A 190
ILE A 325
LEU A 217
ASP A 218
PHE A 128
 None
 0.95A 3ko0A-2qzxA:
undetectable
3ko0B-2qzxA:
undetectable
3ko0C-2qzxA:
undetectable
3ko0D-2qzxA:
undetectable		 3ko0A-2qzxA:
17.17
3ko0B-2qzxA:
17.17
3ko0C-2qzxA:
17.17
3ko0D-2qzxA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 LEU A 738
ILE A 769
PHE A 705
ASP A 748
PHE A 751
 None
 1.14A 3ko0A-2v26A:
undetectable
3ko0B-2v26A:
undetectable
3ko0C-2v26A:
undetectable
3ko0D-2v26A:
undetectable		 3ko0A-2v26A:
9.24
3ko0B-2v26A:
9.24
3ko0C-2v26A:
9.24
3ko0D-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vri NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
NL63) 		PF01661
(Macro) 		5 LEU A 134
SER A 136
PHE A 135
ILE A 139
LEU A 107
 None
 1.24A 3ko0A-2vriA:
undetectable
3ko0B-2vriA:
undetectable
3ko0C-2vriA:
undetectable
3ko0D-2vriA:
undetectable		 3ko0A-2vriA:
21.43
3ko0B-2vriA:
21.43
3ko0C-2vriA:
21.43
3ko0D-2vriA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 363
ILE A 398
PHE A 107
ASP A 402
ASP A 141
 None
 1.15A 3ko0A-2wn4A:
undetectable
3ko0B-2wn4A:
undetectable
3ko0C-2wn4A:
undetectable
3ko0D-2wn4A:
undetectable		 3ko0A-2wn4A:
13.10
3ko0B-2wn4A:
13.10
3ko0C-2wn4A:
13.10
3ko0D-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A 218
SER A 217
GLU A 201
LEU A 168
ASP A 202
 None
None
None
None
PGU  A 500 (-2.8A)
 1.25A 3ko0A-2zyjA:
undetectable
3ko0B-2zyjA:
undetectable
3ko0C-2zyjA:
undetectable
3ko0D-2zyjA:
undetectable		 3ko0A-2zyjA:
14.80
3ko0B-2zyjA:
14.80
3ko0C-2zyjA:
14.80
3ko0D-2zyjA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU B  68
SER B  70
PHE B  71
LEU B 106
PHE B  85
 None
HEM  B 401 ( 3.8A)
None
HEM  B 401 ( 4.5A)
None
 1.16A 3ko0A-3a0gB:
undetectable
3ko0B-3a0gB:
undetectable
3ko0C-3a0gB:
undetectable
3ko0D-3a0gB:
undetectable		 3ko0A-3a0gB:
21.92
3ko0B-3a0gB:
21.92
3ko0C-3a0gB:
21.92
3ko0D-3a0gB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		5 LEU A  25
PHE A  22
ILE A  49
LEU A  69
PHE A  81
 None
 1.23A 3ko0A-3e1kA:
undetectable
3ko0B-3e1kA:
undetectable
3ko0C-3e1kA:
undetectable
3ko0D-3e1kA:
undetectable		 3ko0A-3e1kA:
13.62
3ko0B-3e1kA:
13.62
3ko0C-3e1kA:
13.62
3ko0D-3e1kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 SER A 171
PHE A 410
ILE A 395
PHE A 298
ASP A 164
 None
 1.21A 3ko0A-3eafA:
undetectable
3ko0B-3eafA:
undetectable
3ko0C-3eafA:
undetectable
3ko0D-3eafA:
undetectable		 3ko0A-3eafA:
12.92
3ko0B-3eafA:
12.92
3ko0C-3eafA:
12.92
3ko0D-3eafA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 LEU A 146
ILE A 122
CYH A 133
PHE A 132
LEU A 154
 None
 1.20A 3ko0A-3fkdA:
undetectable
3ko0B-3fkdA:
undetectable
3ko0C-3fkdA:
undetectable
3ko0D-3fkdA:
undetectable		 3ko0A-3fkdA:
12.82
3ko0B-3fkdA:
12.82
3ko0C-3fkdA:
12.82
3ko0D-3fkdA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8w LACTOCOCCAL PROPHAGE
PS3 PROTEIN 05

(Staphylococcus
epidermidis) 		PF13420
(Acetyltransf_4) 		5 LEU A 115
ILE A 103
CYH A  67
PHE A  87
LEU A  69
 None
 1.21A 3ko0A-3g8wA:
undetectable
3ko0B-3g8wA:
undetectable
3ko0C-3g8wA:
undetectable
3ko0D-3g8wA:
undetectable		 3ko0A-3g8wA:
25.00
3ko0B-3g8wA:
25.00
3ko0C-3g8wA:
25.00
3ko0D-3g8wA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 293
SER A 290
ILE A 257
CYH A 259
LEU A 312
 None
 1.11A 3ko0A-3h11A:
undetectable
3ko0B-3h11A:
undetectable
3ko0C-3h11A:
undetectable
3ko0D-3h11A:
undetectable		 3ko0A-3h11A:
15.79
3ko0B-3h11A:
15.79
3ko0C-3h11A:
15.79
3ko0D-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		5 LEU A 161
ILE A 166
CYH A 174
LEU A 203
SER A 191
 None
 1.21A 3ko0A-3h7kA:
undetectable
3ko0B-3h7kA:
undetectable
3ko0C-3h7kA:
undetectable
3ko0D-3h7kA:
undetectable		 3ko0A-3h7kA:
14.13
3ko0B-3h7kA:
14.13
3ko0C-3h7kA:
14.13
3ko0D-3h7kA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 5 LEU A 181
SER A 178
ILE A  68
PHE A 240
ASP A 172
 None
 1.17A 3ko0A-3hwpA:
undetectable
3ko0B-3hwpA:
undetectable
3ko0C-3hwpA:
undetectable
3ko0D-3hwpA:
undetectable		 3ko0A-3hwpA:
15.77
3ko0B-3hwpA:
15.77
3ko0C-3hwpA:
15.77
3ko0D-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 416
ILE A 408
LEU A 437
ASP A 436
PHE A 381
 None
None
None
NDG  A4701 ( 3.1A)
None
 1.18A 3ko0A-3i2tA:
undetectable
3ko0B-3i2tA:
undetectable
3ko0C-3i2tA:
undetectable
3ko0D-3i2tA:
undetectable		 3ko0A-3i2tA:
11.34
3ko0B-3i2tA:
11.34
3ko0C-3i2tA:
11.34
3ko0D-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 LEU A  19
PHE A  48
LEU A 115
ASP A 101
SER A  25
 None
 1.14A 3ko0A-3jr3A:
undetectable
3ko0B-3jr3A:
undetectable
3ko0C-3jr3A:
undetectable
3ko0D-3jr3A:
undetectable		 3ko0A-3jr3A:
20.18
3ko0B-3jr3A:
20.18
3ko0C-3jr3A:
20.18
3ko0D-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		5 LEU A 170
PHE A 147
ILE A 103
LEU A  79
ASP A 142
 None
 1.24A 3ko0A-3k4zA:
undetectable
3ko0B-3k4zA:
undetectable
3ko0C-3k4zA:
undetectable
3ko0D-3k4zA:
undetectable		 3ko0A-3k4zA:
16.07
3ko0B-3k4zA:
16.07
3ko0C-3k4zA:
16.07
3ko0D-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		5 LEU A 289
SER A 285
PHE A 288
ILE A 251
ASP A 229
 None
None
None
None
FE  A 334 (-3.1A)
 1.26A 3ko0A-3ktcA:
undetectable
3ko0B-3ktcA:
undetectable
3ko0C-3ktcA:
undetectable
3ko0D-3ktcA:
undetectable		 3ko0A-3ktcA:
16.22
3ko0B-3ktcA:
16.22
3ko0C-3ktcA:
16.22
3ko0D-3ktcA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4

(Homo sapiens) 		no annotation 5 LEU A 230
SER A 331
ILE A 254
PHE A 251
SER A 377
 None
 1.12A 3ko0A-3l15A:
undetectable
3ko0B-3l15A:
undetectable
3ko0C-3l15A:
undetectable
3ko0D-3l15A:
undetectable		 3ko0A-3l15A:
20.36
3ko0B-3l15A:
20.36
3ko0C-3l15A:
20.36
3ko0D-3l15A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		5 SER A 288
ILE A 324
GLU A 297
LEU A 301
ASP A 299
 None
 1.11A 3ko0A-3odpA:
undetectable
3ko0B-3odpA:
undetectable
3ko0C-3odpA:
undetectable
3ko0D-3odpA:
undetectable		 3ko0A-3odpA:
14.32
3ko0B-3odpA:
14.32
3ko0C-3odpA:
14.32
3ko0D-3odpA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph2 CYTOCHROME C6

(Phormidium
laminosum) 		PF13442
(Cytochrome_CBB3) 		5 LEU B  37
ILE B  48
LEU B  79
ASP B  80
PHE B  11
 None
HEM  B1087 ( 4.4A)
None
None
None
 1.20A 3ko0A-3ph2B:
undetectable
3ko0B-3ph2B:
undetectable
3ko0C-3ph2B:
undetectable
3ko0D-3ph2B:
undetectable		 3ko0A-3ph2B:
19.00
3ko0B-3ph2B:
19.00
3ko0C-3ph2B:
19.00
3ko0D-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 203
ILE A 169
LEU A 223
ASP A 222
PHE A 253
 None
 1.18A 3ko0A-3skvA:
undetectable
3ko0B-3skvA:
undetectable
3ko0C-3skvA:
undetectable
3ko0D-3skvA:
undetectable		 3ko0A-3skvA:
14.71
3ko0B-3skvA:
14.71
3ko0C-3skvA:
14.71
3ko0D-3skvA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		5 LEU A 341
SER A 343
ILE A 199
LEU A 177
ASP A 170
 None
 1.20A 3ko0A-3sqiA:
undetectable
3ko0B-3sqiA:
undetectable
3ko0C-3sqiA:
undetectable
3ko0D-3sqiA:
undetectable		 3ko0A-3sqiA:
12.24
3ko0B-3sqiA:
12.24
3ko0C-3sqiA:
12.24
3ko0D-3sqiA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj7 GBAA_1210 PROTEIN

(Bacillus
anthracis) 		PF01928
(CYTH) 		5 LEU A  45
SER A  43
ILE A 108
GLU A  39
LEU A 113
 None
 1.25A 3ko0A-3tj7A:
undetectable
3ko0B-3tj7A:
undetectable
3ko0C-3tj7A:
undetectable
3ko0D-3tj7A:
undetectable		 3ko0A-3tj7A:
19.49
3ko0B-3tj7A:
19.49
3ko0C-3tj7A:
19.49
3ko0D-3tj7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 LEU A 324
SER A 321
ILE A 293
LEU A 260
ASP A 132
 None
 1.24A 3ko0A-3uduA:
0.6
3ko0B-3uduA:
0.6
3ko0C-3uduA:
undetectable
3ko0D-3uduA:
undetectable		 3ko0A-3uduA:
16.22
3ko0B-3uduA:
16.22
3ko0C-3uduA:
16.22
3ko0D-3uduA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		5 LEU A  62
ILE A  69
GLU A  92
LEU A  96
SER A  85
 None
 1.12A 3ko0A-3ue9A:
undetectable
3ko0B-3ue9A:
undetectable
3ko0C-3ue9A:
undetectable
3ko0D-3ue9A:
undetectable		 3ko0A-3ue9A:
13.17
3ko0B-3ue9A:
13.17
3ko0C-3ue9A:
13.17
3ko0D-3ue9A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxm C1-28 TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU E  78
SER E  65
PHE E  64
LEU E  21
PHE E  47
 None
 1.26A 3ko0A-3vxmE:
undetectable
3ko0B-3vxmE:
undetectable
3ko0C-3vxmE:
undetectable
3ko0D-3vxmE:
undetectable		 3ko0A-3vxmE:
21.30
3ko0B-3vxmE:
21.30
3ko0C-3vxmE:
21.30
3ko0D-3vxmE:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 325
ILE A 229
LEU A 277
ASP A 342
PHE A 283
 None
 1.24A 3ko0A-3wdjA:
undetectable
3ko0B-3wdjA:
undetectable
3ko0C-3wdjA:
undetectable
3ko0D-3wdjA:
undetectable		 3ko0A-3wdjA:
9.15
3ko0B-3wdjA:
9.15
3ko0C-3wdjA:
9.15
3ko0D-3wdjA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 LEU A 334
PHE A 333
ILE A 236
PHE A 264
ASP A 325
 None
 1.13A 3ko0A-3wnpA:
undetectable
3ko0B-3wnpA:
undetectable
3ko0C-3wnpA:
undetectable
3ko0D-3wnpA:
undetectable		 3ko0A-3wnpA:
9.04
3ko0B-3wnpA:
9.04
3ko0C-3wnpA:
9.04
3ko0D-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 LEU A 738
ILE A 769
PHE A 705
ASP A 748
PHE A 751
 None
 1.21A 3ko0A-4anjA:
undetectable
3ko0B-4anjA:
undetectable
3ko0C-4anjA:
undetectable
3ko0D-4anjA:
undetectable		 3ko0A-4anjA:
6.93
3ko0B-4anjA:
6.93
3ko0C-4anjA:
6.93
3ko0D-4anjA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 LEU A 332
PHE A 327
ILE A 325
ASP A 318
ASP A 351
 None
 1.23A 3ko0A-4bhdA:
undetectable
3ko0B-4bhdA:
undetectable
3ko0C-4bhdA:
undetectable
3ko0D-4bhdA:
undetectable		 3ko0A-4bhdA:
12.38
3ko0B-4bhdA:
12.38
3ko0C-4bhdA:
12.38
3ko0D-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 LEU A 561
ILE A 550
LEU A 535
ASP A 570
SER A 596
 None
 1.27A 3ko0A-4ecnA:
undetectable
3ko0B-4ecnA:
undetectable
3ko0C-4ecnA:
undetectable
3ko0D-4ecnA:
undetectable		 3ko0A-4ecnA:
9.28
3ko0B-4ecnA:
9.28
3ko0C-4ecnA:
9.28
3ko0D-4ecnA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 228
SER A 231
ILE A 288
PHE A 252
GLU A 214
 None
 1.17A 3ko0A-4fidA:
undetectable
3ko0B-4fidA:
undetectable
3ko0C-4fidA:
undetectable
3ko0D-4fidA:
undetectable		 3ko0A-4fidA:
15.16
3ko0B-4fidA:
15.16
3ko0C-4fidA:
15.16
3ko0D-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 228
SER A 231
PHE A 252
GLU A 214
PHE A 208
 None
 1.12A 3ko0A-4fidA:
undetectable
3ko0B-4fidA:
undetectable
3ko0C-4fidA:
undetectable
3ko0D-4fidA:
undetectable		 3ko0A-4fidA:
15.16
3ko0B-4fidA:
15.16
3ko0C-4fidA:
15.16
3ko0D-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 164
SER A 120
LEU A  84
PHE A 117
ASP A  70
 None
 1.23A 3ko0A-4h5iA:
undetectable
3ko0B-4h5iA:
undetectable
3ko0C-4h5iA:
undetectable
3ko0D-4h5iA:
undetectable		 3ko0A-4h5iA:
15.69
3ko0B-4h5iA:
15.69
3ko0C-4h5iA:
15.69
3ko0D-4h5iA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.22A 3ko0A-4hwtA:
1.2
3ko0B-4hwtA:
1.2
3ko0C-4hwtA:
1.1
3ko0D-4hwtA:
1.1		 3ko0A-4hwtA:
14.49
3ko0B-4hwtA:
14.49
3ko0C-4hwtA:
14.49
3ko0D-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 LEU A 364
ILE A 368
GLU A 350
LEU A 347
ASP A 346
 None
 1.04A 3ko0A-4iggA:
undetectable
3ko0B-4iggA:
undetectable
3ko0C-4iggA:
undetectable
3ko0D-4iggA:
undetectable		 3ko0A-4iggA:
9.16
3ko0B-4iggA:
9.16
3ko0C-4iggA:
9.16
3ko0D-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		5 LEU A  45
PHE A  66
ILE A  11
LEU A 240
ASP A 241
 None
 1.15A 3ko0A-4iwmA:
undetectable
3ko0B-4iwmA:
undetectable
3ko0C-4iwmA:
1.2
3ko0D-4iwmA:
undetectable		 3ko0A-4iwmA:
17.05
3ko0B-4iwmA:
17.05
3ko0C-4iwmA:
17.05
3ko0D-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		5 LEU A 235
ILE A  98
LEU A 108
ASP A 109
SER A 353
 None
 0.92A 3ko0A-4j1lA:
undetectable
3ko0B-4j1lA:
undetectable
3ko0C-4j1lA:
undetectable
3ko0D-4j1lA:
undetectable		 3ko0A-4j1lA:
14.29
3ko0B-4j1lA:
14.29
3ko0C-4j1lA:
14.29
3ko0D-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		5 LEU A1524
SER A1523
ILE A1481
LEU A1480
ASP A1476
 None
 1.22A 3ko0A-4lnzA:
1.6
3ko0B-4lnzA:
1.7
3ko0C-4lnzA:
1.7
3ko0D-4lnzA:
1.6		 3ko0A-4lnzA:
14.90
3ko0B-4lnzA:
14.90
3ko0C-4lnzA:
14.90
3ko0D-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 311
ILE A 285
LEU A 298
ASP A 322
PHE A 352
 None
 1.21A 3ko0A-4m7eA:
undetectable
3ko0B-4m7eA:
undetectable
3ko0C-4m7eA:
undetectable
3ko0D-4m7eA:
undetectable		 3ko0A-4m7eA:
8.34
3ko0B-4m7eA:
8.34
3ko0C-4m7eA:
8.34
3ko0D-4m7eA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ

(Pseudomonas
putida) 		PF16822
(ALGX) 		5 LEU A 349
PHE A 344
ILE A 112
PHE A 168
ASP A 171
 None
 1.26A 3ko0A-4o8vA:
undetectable
3ko0B-4o8vA:
undetectable
3ko0C-4o8vA:
undetectable
3ko0D-4o8vA:
undetectable		 3ko0A-4o8vA:
16.23
3ko0B-4o8vA:
16.23
3ko0C-4o8vA:
16.23
3ko0D-4o8vA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 LEU A  85
PHE A  92
ILE A  67
LEU A 129
PHE A 119
 None
 1.18A 3ko0A-4p53A:
undetectable
3ko0B-4p53A:
undetectable
3ko0C-4p53A:
undetectable
3ko0D-4p53A:
undetectable		 3ko0A-4p53A:
12.62
3ko0B-4p53A:
12.62
3ko0C-4p53A:
12.62
3ko0D-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 LEU A  70
SER A  67
ILE A 292
GLU A 132
PHE A  65
 None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
UNX  A 408 ( 4.8A)
 1.17A 3ko0A-4pwyA:
undetectable
3ko0B-4pwyA:
undetectable
3ko0C-4pwyA:
undetectable
3ko0D-4pwyA:
undetectable		 3ko0A-4pwyA:
18.85
3ko0B-4pwyA:
18.85
3ko0C-4pwyA:
18.85
3ko0D-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 LEU A  51
SER A  54
ILE A  78
PHE A1722
LEU A  74
 None
 1.20A 3ko0A-4r04A:
undetectable
3ko0B-4r04A:
undetectable
3ko0C-4r04A:
undetectable
3ko0D-4r04A:
undetectable		 3ko0A-4r04A:
4.44
3ko0B-4r04A:
4.44
3ko0C-4r04A:
4.44
3ko0D-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 LEU A 298
SER A 285
LEU A 279
ASP A 277
ASP A 269
 None
 1.25A 3ko0A-4r1zA:
undetectable
3ko0B-4r1zA:
undetectable
3ko0C-4r1zA:
undetectable
3ko0D-4r1zA:
undetectable		 3ko0A-4r1zA:
14.25
3ko0B-4r1zA:
14.25
3ko0C-4r1zA:
14.25
3ko0D-4r1zA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 390
ILE A 382
CYH A 409
LEU A 377
ASP A 405
 None
 0.97A 3ko0A-4r5dA:
undetectable
3ko0B-4r5dA:
undetectable
3ko0C-4r5dA:
undetectable
3ko0D-4r5dA:
undetectable		 3ko0A-4r5dA:
10.93
3ko0B-4r5dA:
10.93
3ko0C-4r5dA:
10.93
3ko0D-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		5 LEU A  95
ILE A 120
LEU A 114
ASP A 113
PHE A 162
 None
 1.15A 3ko0A-4s1aA:
undetectable
3ko0B-4s1aA:
undetectable
3ko0C-4s1aA:
undetectable
3ko0D-4s1aA:
undetectable		 3ko0A-4s1aA:
18.98
3ko0B-4s1aA:
18.98
3ko0C-4s1aA:
18.98
3ko0D-4s1aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL

(Plasmodium
berghei) 		no annotation 5 PHE A 115
ILE A 138
CYH A 142
LEU A  57
ASP A  60
 None
 1.27A 3ko0A-4u5aA:
1.7
3ko0B-4u5aA:
1.9
3ko0C-4u5aA:
1.9
3ko0D-4u5aA:
1.8		 3ko0A-4u5aA:
20.30
3ko0B-4u5aA:
20.30
3ko0C-4u5aA:
20.30
3ko0D-4u5aA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8t ZYRO0G01672P

(Zygosaccharomyces
rouxii) 		PF04146
(YTH) 		5 CYH A 236
PHE A 235
LEU A 188
ASP A 297
SER A 202
 None
None
None
C  O   1 ( 4.8A)
None
 1.22A 3ko0A-4u8tA:
undetectable
3ko0B-4u8tA:
undetectable
3ko0C-4u8tA:
undetectable
3ko0D-4u8tA:
undetectable		 3ko0A-4u8tA:
19.21
3ko0B-4u8tA:
19.21
3ko0C-4u8tA:
19.21
3ko0D-4u8tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pyrococcus
horikoshii) 		PF01867
(Cas_Cas1) 		5 LEU A  14
ILE A   8
LEU A   6
ASP A  39
PHE A  65
 None
 1.16A 3ko0A-4wj0A:
undetectable
3ko0B-4wj0A:
undetectable
3ko0C-4wj0A:
undetectable
3ko0D-4wj0A:
undetectable		 3ko0A-4wj0A:
16.94
3ko0B-4wj0A:
16.94
3ko0C-4wj0A:
16.94
3ko0D-4wj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 LEU C 359
ILE C 590
CYH C 396
GLU C 592
LEU C 593
 None
 1.22A 3ko0A-4xgcC:
2.6
3ko0B-4xgcC:
2.6
3ko0C-4xgcC:
2.6
3ko0D-4xgcC:
2.7		 3ko0A-4xgcC:
8.97
3ko0B-4xgcC:
8.97
3ko0C-4xgcC:
8.97
3ko0D-4xgcC:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2842
SER A2844
PHE A2845
LEU A2830
ASP A2854
 None
 1.24A 3ko0A-4z37A:
undetectable
3ko0B-4z37A:
undetectable
3ko0C-4z37A:
undetectable
3ko0D-4z37A:
undetectable		 3ko0A-4z37A:
9.61
3ko0B-4z37A:
9.61
3ko0C-4z37A:
9.61
3ko0D-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 577
ILE A 573
LEU A 588
ASP A 587
PHE A 627
 None
 1.07A 3ko0A-4z61A:
undetectable
3ko0B-4z61A:
undetectable
3ko0C-4z61A:
undetectable
3ko0D-4z61A:
undetectable		 3ko0A-4z61A:
10.84
3ko0B-4z61A:
10.84
3ko0C-4z61A:
10.84
3ko0D-4z61A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 567
ILE A 563
LEU A 578
ASP A 577
PHE A 617
 None
 1.11A 3ko0A-4z64A:
undetectable
3ko0B-4z64A:
undetectable
3ko0C-4z64A:
undetectable
3ko0D-4z64A:
undetectable		 3ko0A-4z64A:
11.79
3ko0B-4z64A:
11.79
3ko0C-4z64A:
11.79
3ko0D-4z64A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		5 LEU A 126
PHE A 122
LEU A  56
ASP A  57
SER A  40
 None
None
None
None
DMS  A1314 ( 3.7A)
 1.20A 3ko0A-5advA:
undetectable
3ko0B-5advA:
undetectable
3ko0C-5advA:
undetectable
3ko0D-5advA:
undetectable		 3ko0A-5advA:
15.55
3ko0B-5advA:
15.55
3ko0C-5advA:
15.55
3ko0D-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		5 LEU A  50
SER A  51
ILE A  46
GLU A 106
LEU A 109
 None
 1.05A 3ko0A-5azdA:
1.5
3ko0B-5azdA:
1.8
3ko0C-5azdA:
1.6
3ko0D-5azdA:
0.7		 3ko0A-5azdA:
15.53
3ko0B-5azdA:
15.53
3ko0C-5azdA:
15.53
3ko0D-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 LEU B 168
SER B  83
PHE B  82
LEU A 387
ASP B  16
 None
None
None
None
EDO  B 205 (-3.6A)
 1.13A 3ko0A-5b8iB:
5.9
3ko0B-5b8iB:
6.3
3ko0C-5b8iB:
6.1
3ko0D-5b8iB:
6.2		 3ko0A-5b8iB:
19.54
3ko0B-5b8iB:
19.54
3ko0C-5b8iB:
19.54
3ko0D-5b8iB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 LEU A  26
ILE A  61
GLU A  23
ASP A 417
SER A 403
 None
 1.25A 3ko0A-5cykA:
undetectable
3ko0B-5cykA:
undetectable
3ko0C-5cykA:
undetectable
3ko0D-5cykA:
undetectable		 3ko0A-5cykA:
10.91
3ko0B-5cykA:
10.91
3ko0C-5cykA:
10.91
3ko0D-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		5 LEU A  24
ILE A 277
GLU A 265
LEU A 261
ASP A 263
 None
 1.16A 3ko0A-5d86A:
undetectable
3ko0B-5d86A:
undetectable
3ko0C-5d86A:
undetectable
3ko0D-5d86A:
undetectable		 3ko0A-5d86A:
16.92
3ko0B-5d86A:
16.92
3ko0C-5d86A:
16.92
3ko0D-5d86A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		5 LEU E 285
PHE E 246
ILE E 213
LEU E 209
ASP E 237
 None
 1.17A 3ko0A-5esvE:
undetectable
3ko0B-5esvE:
undetectable
3ko0C-5esvE:
undetectable
3ko0D-5esvE:
undetectable		 3ko0A-5esvE:
20.39
3ko0B-5esvE:
20.39
3ko0C-5esvE:
20.39
3ko0D-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 LEU D 394
ILE D 401
CYH D 405
LEU D 382
ASP D 358
 None
 1.20A 3ko0A-5exrD:
undetectable
3ko0B-5exrD:
undetectable
3ko0C-5exrD:
undetectable
3ko0D-5exrD:
undetectable		 3ko0A-5exrD:
13.78
3ko0B-5exrD:
13.78
3ko0C-5exrD:
13.78
3ko0D-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 LEU A  60
ILE A  78
CYH A  80
PHE A 155
LEU A 148
 None
 1.27A 3ko0A-5heiA:
undetectable
3ko0B-5heiA:
undetectable
3ko0C-5heiA:
undetectable
3ko0D-5heiA:
undetectable		 3ko0A-5heiA:
19.84
3ko0B-5heiA:
19.84
3ko0C-5heiA:
19.84
3ko0D-5heiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 LEU A 230
ILE A 105
LEU A 271
ASP A 240
SER A  51
 None
None
None
SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
 1.09A 3ko0A-5hxsA:
undetectable
3ko0B-5hxsA:
undetectable
3ko0C-5hxsA:
undetectable
3ko0D-5hxsA:
undetectable		 3ko0A-5hxsA:
12.62
3ko0B-5hxsA:
12.62
3ko0C-5hxsA:
12.62
3ko0D-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 LEU A  94
SER A  95
PHE A  69
ILE A  74
SER A 164
 None
 1.09A 3ko0A-5hyhA:
undetectable
3ko0B-5hyhA:
undetectable
3ko0C-5hyhA:
undetectable
3ko0D-5hyhA:
undetectable		 3ko0A-5hyhA:
14.19
3ko0B-5hyhA:
14.19
3ko0C-5hyhA:
14.19
3ko0D-5hyhA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 LEU B 361
SER B 386
CYH B 381
ASP B 376
ASP B 397
 None
 1.19A 3ko0A-5hzgB:
undetectable
3ko0B-5hzgB:
undetectable
3ko0C-5hzgB:
undetectable
3ko0D-5hzgB:
undetectable		 3ko0A-5hzgB:
8.73
3ko0B-5hzgB:
8.73
3ko0C-5hzgB:
8.73
3ko0D-5hzgB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 484
SER A 483
PHE A 487
GLU A 350
ASP A 351
 None
 1.17A 3ko0A-5iudA:
undetectable
3ko0B-5iudA:
undetectable
3ko0C-5iudA:
undetectable
3ko0D-5iudA:
undetectable		 3ko0A-5iudA:
7.87
3ko0B-5iudA:
7.87
3ko0C-5iudA:
7.87
3ko0D-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 143
SER B 134
ILE B 183
LEU B 164
ASP B 138
 None
 1.12A 3ko0A-5k1cB:
undetectable
3ko0B-5k1cB:
undetectable
3ko0C-5k1cB:
undetectable
3ko0D-5k1cB:
undetectable		 3ko0A-5k1cB:
9.96
3ko0B-5k1cB:
9.96
3ko0C-5k1cB:
9.96
3ko0D-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 5 LEU A  42
PHE A  41
ILE A 175
LEU A 199
ASP A 189
 None
 1.22A 3ko0A-5n72A:
undetectable
3ko0B-5n72A:
undetectable
3ko0C-5n72A:
undetectable
3ko0D-5n72A:
undetectable		 3ko0A-5n72A:
14.02
3ko0B-5n72A:
14.02
3ko0C-5n72A:
14.02
3ko0D-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 5 LEU A 199
PHE A 198
ILE A  48
LEU A  42
ASP A 189
 None
 1.25A 3ko0A-5n72A:
undetectable
3ko0B-5n72A:
undetectable
3ko0C-5n72A:
undetectable
3ko0D-5n72A:
undetectable		 3ko0A-5n72A:
14.02
3ko0B-5n72A:
14.02
3ko0C-5n72A:
14.02
3ko0D-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 5 LEU A 129
ILE A 104
LEU A 107
ASP A 108
PHE A  75
 None
 1.14A 3ko0A-5ubvA:
undetectable
3ko0B-5ubvA:
undetectable
3ko0C-5ubvA:
undetectable
3ko0D-5ubvA:
undetectable		 3ko0A-5ubvA:
21.05
3ko0B-5ubvA:
21.05
3ko0C-5ubvA:
21.05
3ko0D-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 SER B 145
ILE B 150
LEU B 111
ASP B 109
ASP B  72
 None
 1.12A 3ko0A-5y3rB:
undetectable
3ko0B-5y3rB:
undetectable
3ko0C-5y3rB:
undetectable
3ko0D-5y3rB:
undetectable		 3ko0A-5y3rB:
11.39
3ko0B-5y3rB:
11.39
3ko0C-5y3rB:
11.39
3ko0D-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 LEU A 329
ILE A 308
LEU A 310
ASP A 386
SER A 333
 None
 1.23A 3ko0A-6bbpA:
undetectable
3ko0B-6bbpA:
undetectable
3ko0C-6bbpA:
undetectable
3ko0D-6bbpA:
undetectable		 3ko0A-6bbpA:
20.56
3ko0B-6bbpA:
20.56
3ko0C-6bbpA:
20.56
3ko0D-6bbpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens) 		no annotation 5 LEU E 167
PHE E 113
ILE E 147
ASP A  48
SER A  46
 None
 1.20A 3ko0A-6d6uE:
undetectable
3ko0B-6d6uE:
undetectable
3ko0C-6d6uE:
undetectable
3ko0D-6d6uE:
undetectable		 3ko0A-6d6uE:
21.15
3ko0B-6d6uE:
21.15
3ko0C-6d6uE:
21.15
3ko0D-6d6uE:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
 None
 1.08A 3ko0A-6evjB:
undetectable
3ko0B-6evjB:
undetectable
3ko0C-6evjB:
undetectable
3ko0D-6evjB:
undetectable		 3ko0A-6evjB:
17.92
3ko0B-6evjB:
17.92
3ko0C-6evjB:
17.92
3ko0D-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 5 LEU A 802
GLU A 775
LEU A 772
ASP A 771
ASP A 874
 None
 1.26A 3ko0A-6fekA:
undetectable
3ko0B-6fekA:
undetectable
3ko0C-6fekA:
undetectable
3ko0D-6fekA:
undetectable		 3ko0A-6fekA:
23.53
3ko0B-6fekA:
23.53
3ko0C-6fekA:
23.53
3ko0D-6fekA:
23.53