SIMILAR PATTERNS OF AMINO ACIDS FOR 3KM6_A_EAAA222

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		5 GLY A 162
VAL A 170
TRP A 146
ILE A 154
ASN A 163
 None
 1.16A 3km6A-1a3gA:
undetectable		 3km6A-1a3gA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 GLY A 431
VAL A 258
TRP A 316
ILE A 458
GLY A 254
 None
 1.00A 3km6A-1aorA:
undetectable		 3km6A-1aorA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7n BETA-CRYSTALLIN B2

(Mus musculus) 		PF00030
(Crystall) 		5 TYR A  62
VAL A  37
GLY A  60
VAL A  43
GLN A  54
 None
 1.28A 3km6A-1e7nA:
undetectable		 3km6A-1e7nA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 TYR A 138
VAL A 129
VAL A  15
ASN A 131
GLY A 117
 None
 1.27A 3km6A-1ebdA:
undetectable		 3km6A-1ebdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 VAL A 107
GLY A 111
VAL A  20
ILE A  91
GLY A  41
 None
 1.28A 3km6A-1f0kA:
undetectable		 3km6A-1f0kA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 PHE A 370
VAL A 372
GLY A 375
ASN A 378
GLY A 380
 None
 1.24A 3km6A-1gk2A:
undetectable		 3km6A-1gk2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00117
(GATase) 		5 TYR H  10
PHE H  59
VAL H  55
GLY H  48
ILE H  81
 None
 1.21A 3km6A-1ka9H:
undetectable		 3km6A-1ka9H:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		8 TYR A   7
PHE A   8
VAL A  10
GLY A  12
VAL A  35
TRP A  38
GLN A  39
ILE A 104
 None
GSH  A 504 (-4.7A)
None
None
None
GSH  A 504 (-3.9A)
None
None
 0.53A 3km6A-1lbkA:
35.8		 3km6A-1lbkA:
96.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4y ATP-DEPENDENT
PROTEASE HSLV

(Thermotoga
maritima) 		PF00227
(Proteasome) 		5 VAL A  34
GLY A  45
GLN A  11
ILE A 122
GLY A  15
 None
 1.17A 3km6A-1m4yA:
undetectable		 3km6A-1m4yA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m8u GAMMA-E

(Bos taurus) 		PF00030
(Crystall) 		5 TYR A 151
VAL A 126
GLY A 149
VAL A 132
GLN A 143
 None
 1.28A 3km6A-1m8uA:
undetectable		 3km6A-1m8uA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		5 VAL K 213
GLY K 196
VAL K 158
ASN K 143
GLY K 193
 None
 1.18A 3km6A-1mkxK:
undetectable		 3km6A-1mkxK:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 VAL A 333
GLY A 341
VAL A  46
ILE A 362
GLY A   4
 None
 1.20A 3km6A-1ofeA:
undetectable		 3km6A-1ofeA:
9.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tu7 GLUTATHIONE
S-TRANSFERASE 2

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TYR A   7
PHE A   8
GLY A  12
ASN A 203
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.35A 3km6A-1tu7A:
30.6		 3km6A-1tu7A:
41.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		5 VAL A  10
GLY A  79
VAL A 217
ILE A  48
GLY A  20
 None
 1.32A 3km6A-1u0kA:
undetectable		 3km6A-1u0kA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 VAL A 269
GLY A 258
VAL A  46
ILE A  67
GLY A 209
 None
 1.33A 3km6A-1u60A:
undetectable		 3km6A-1u60A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 VAL A 132
GLY A  51
TRP A 418
GLN A 419
ILE A  63
 None
 1.11A 3km6A-1v8bA:
undetectable		 3km6A-1v8bA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE

(Neisseria
gonorrhoeae) 		PF01128
(IspD) 		5 VAL A  54
GLY A  78
VAL A 107
ASN A  88
GLY A  89
 None
 1.16A 3km6A-1vgwA:
undetectable		 3km6A-1vgwA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr8 GTP BINDING
REGULATOR

(Thermotoga
maritima) 		PF11586
(DUF3242) 		5 PHE A 141
GLY A  71
VAL A 142
ASN A 136
GLY A 137
 None
None
GOL  A   4 (-4.5A)
None
None
 1.32A 3km6A-1vr8A:
undetectable		 3km6A-1vr8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		5 GLY A  33
TRP A 107
GLN A 106
ASN A  34
GLY A  37
 None
 1.31A 3km6A-1x2bA:
undetectable		 3km6A-1x2bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		5 PHE A  76
VAL A  38
VAL A  81
ILE A 148
GLY A  47
 None
 1.18A 3km6A-1xqpA:
undetectable		 3km6A-1xqpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb2 BETA B2-CRYSTALLIN

(Bos taurus) 		PF00030
(Crystall) 		5 TYR A  62
PHE A  57
VAL A  37
GLY A  60
GLY A  40
 None
 1.31A 3km6A-2bb2A:
undetectable		 3km6A-2bb2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dad ABSENT IN MELANOMA 1
PROTEIN

(Homo sapiens) 		PF00030
(Crystall) 		5 TYR A  67
VAL A  42
GLY A  65
VAL A  48
GLN A  59
 None
 1.06A 3km6A-2dadA:
undetectable		 3km6A-2dadA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eih ALCOHOL
DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 335
VAL A 334
VAL A 181
GLN A 185
GLY A 314
 None
 1.20A 3km6A-2eihA:
undetectable		 3km6A-2eihA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fli RIBULOSE-PHOSPHATE
3-EPIMERASE

(Streptococcus
pyogenes) 		PF00834
(Ribul_P_3_epim) 		5 PHE A  42
GLY A 143
VAL A  71
ASN A  45
GLY A  40
 None
DX5  A1901 (-3.6A)
None
None
None
 1.26A 3km6A-2fliA:
undetectable		 3km6A-2fliA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh8 CAPSID PROTEIN

(Vesicular
exanthema of
swine virus) 		PF00915
(Calici_coat) 		5 PHE A 659
GLY A 662
VAL A 702
ASN A 601
GLY A 672
 None
 1.28A 3km6A-2gh8A:
undetectable		 3km6A-2gh8A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh8 CAPSID PROTEIN

(Vesicular
exanthema of
swine virus) 		PF00915
(Calici_coat) 		6 VAL A 671
GLY A 662
VAL A 702
TRP A 658
GLN A 657
ILE A 374
 None
 1.32A 3km6A-2gh8A:
undetectable		 3km6A-2gh8A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpr GLUCOSE-PERMEASE IIA
COMPONENT

(Mycoplasma
capricolum) 		PF00358
(PTS_EIIA_1) 		5 PHE A  34
GLY A  42
VAL A  33
ILE A  80
GLY A  40
 None
 1.30A 3km6A-2gprA:
undetectable		 3km6A-2gprA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus scrofa) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		7 TYR A   7
PHE A   8
VAL A  10
GLY A  12
TRP A  38
ASN A 202
GLY A 203
 GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
None
GTS  A 208 (-3.9A)
None
None
 0.17A 3km6A-2gsrA:
35.5		 3km6A-2gsrA:
81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TYR A  32
PHE A  33
GLY A  37
TRP A  63
ILE A 127
 None
None
None
GSH  A 501 (-3.9A)
None
 0.69A 3km6A-2hnlA:
25.3		 3km6A-2hnlA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 VAL A1156
VAL A1009
TRP A1019
ILE A1032
GLY A1140
 None
 1.33A 3km6A-2iphA:
undetectable		 3km6A-2iphA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 PHE A 457
GLY A 459
VAL A 427
ILE A 476
GLY A 431
 TPW  A1554 (-4.3A)
None
TPW  A1554 ( 4.8A)
None
None
 1.30A 3km6A-2ji9A:
undetectable		 3km6A-2ji9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyp BETA-LACTAMASE II

(Bacillus cereus) 		PF00753
(Lactamase_B) 		5 VAL A 165
GLY A 167
VAL A  82
ASN A  42
GLY A  43
 None
 1.31A 3km6A-2nypA:
undetectable		 3km6A-2nypA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		5 VAL A  79
VAL A 370
GLN A 286
ILE A 190
GLY A  72
 None
 1.28A 3km6A-2qa2A:
undetectable		 3km6A-2qa2A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		6 PHE A 260
VAL A 267
GLY A 268
VAL A  53
TRP A 319
GLY A 302
 None
 1.48A 3km6A-3aatA:
undetectable		 3km6A-3aatA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 TYR A  98
GLY A  85
VAL A  75
GLN A 206
GLY A  80
 None
 1.20A 3km6A-3ayfA:
undetectable		 3km6A-3ayfA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		5 VAL A  85
GLY A 240
VAL A  78
ASN A  90
GLY A  91
 None
 1.19A 3km6A-3b6vA:
undetectable		 3km6A-3b6vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		5 VAL A  46
GLY A  50
VAL A  69
GLN A  34
ILE A 108
 None
 1.31A 3km6A-3c37A:
undetectable		 3km6A-3c37A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF03061
(4HBT) 		5 VAL A 163
GLY A 164
VAL A 141
ASN A 137
GLY A 136
 None
 1.19A 3km6A-3e8pA:
undetectable		 3km6A-3e8pA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5d PROTEIN YDEA

(Bacillus
subtilis) 		PF01965
(DJ-1_PfpI) 		5 VAL A 103
GLY A 101
VAL A 143
ASN A 120
GLY A 119
 None
 1.22A 3km6A-3f5dA:
undetectable		 3km6A-3f5dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLY A  76
TRP A  68
ILE A  50
ASN A  71
GLY A  72
 None
 1.29A 3km6A-3gdcA:
undetectable		 3km6A-3gdcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz8 MUTT/NUDIX FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00293
(NUDIX) 		5 VAL A  39
GLY A  51
VAL A  79
GLN A 113
ILE A 146
 None
 1.30A 3km6A-3gz8A:
undetectable		 3km6A-3gz8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrw HEMOGLOBIN SUBUNIT
BETA-1

(Mus musculus) 		PF00042
(Globin) 		5 VAL B 134
VAL B  67
ILE B 112
ASN B 108
GLY B 107
 None
HEM  B 200 (-3.6A)
None
None
None
 1.30A 3km6A-3hrwB:
undetectable		 3km6A-3hrwB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kht RESPONSE REGULATOR

(Hahella
chejuensis) 		PF00072
(Response_reg) 		5 VAL A  78
GLY A  49
ILE A  72
ASN A  74
GLY A  75
 None
 1.10A 3km6A-3khtA:
undetectable		 3km6A-3khtA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 TYR A  14
VAL A 126
GLY A 125
VAL A 330
GLY A 285
 None
 1.03A 3km6A-3lpdA:
undetectable		 3km6A-3lpdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwk BETA-CRYSTALLIN A4

(Homo sapiens) 		PF00030
(Crystall) 		5 TYR A  74
VAL A  49
GLY A  72
VAL A  55
GLN A  66
 None
 1.26A 3km6A-3lwkA:
undetectable		 3km6A-3lwkA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn1 PROBABLE YRBI FAMILY
PHOSPHATASE

(Pseudomonas
savastanoi) 		PF08282
(Hydrolase_3) 		5 PHE A  22
VAL A  27
GLY A 152
VAL A  21
GLY A 115
 None
 1.07A 3km6A-3mn1A:
undetectable		 3km6A-3mn1A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nro LMO1026 PROTEIN

(Listeria
monocytogenes) 		PF03816
(LytR_cpsA_psr) 		5 VAL A 248
GLY A 249
VAL A 167
ASN A 251
GLY A 162
 None
 1.32A 3km6A-3nroA:
undetectable		 3km6A-3nroA:
19.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		7 TYR A   7
PHE A   8
VAL A  10
GLY A  12
TRP A  38
ASN A 204
GLY A 205
 None
GTB  A 210 (-4.5A)
None
None
GTB  A 210 (-4.0A)
None
GTB  A 210 (-3.7A)
 0.25A 3km6A-3o76A:
36.4		 3km6A-3o76A:
84.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 VAL A 190
GLY A 188
VAL A 162
ASN A 166
GLY A 165
 None
 1.17A 3km6A-3of3A:
undetectable		 3km6A-3of3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ono RIBOSE/GALACTOSE
ISOMERASE

(Vibrio
parahaemolyticus) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		5 VAL A  88
GLY A  86
GLN A 150
ASN A 108
GLY A 107
 None
GOL  A 215 (-3.7A)
None
GOL  A 215 (-3.5A)
GOL  A 215 (-3.6A)
 1.14A 3km6A-3onoA:
undetectable		 3km6A-3onoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		5 VAL A  24
GLY A  23
TRP A  19
ILE A 125
GLY A  45
 None
NAD  A 343 (-3.3A)
None
None
None
 1.14A 3km6A-3rucA:
undetectable		 3km6A-3rucA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		5 VAL A  10
GLY A  42
GLN A 188
ASN A  41
GLY A   8
 None
 1.23A 3km6A-3si9A:
undetectable		 3km6A-3si9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 VAL A  29
GLY A  67
GLN A  86
ILE A 201
GLY A  65
 None
 1.25A 3km6A-3stjA:
undetectable		 3km6A-3stjA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 TYR A  14
VAL A 126
GLY A 125
VAL A 330
GLY A 285
 None
 1.00A 3km6A-3ti7A:
undetectable		 3km6A-3ti7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtf UDP-GLUCOSE
6-DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 TYR A 237
GLY A 255
VAL A 234
ASN A 223
GLY A 226
 None
UPG  A1001 (-3.2A)
None
None
None
 1.31A 3km6A-3vtfA:
undetectable		 3km6A-3vtfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		5 GLY A 401
VAL A 152
ILE A 391
ASN A 264
GLY A 263
 None
 1.21A 3km6A-3wecA:
undetectable		 3km6A-3wecA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		5 PHE A 384
GLY A 387
TRP A 108
ILE A  67
GLY A  45
 None
CL  A 501 (-3.5A)
None
None
None
 1.23A 3km6A-3wkhA:
2.8		 3km6A-3wkhA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwy D-LACTATE
DEHYDROGENASE

(Fusobacterium
nucleatum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 PHE A 189
VAL A 183
ILE A 152
ASN A 207
GLY A 158
 None
 1.22A 3km6A-3wwyA:
undetectable		 3km6A-3wwyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0t UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 5 VAL A  17
GLY A 104
VAL A  95
GLN A  56
GLY A  22
 None
 1.22A 3km6A-3x0tA:
undetectable		 3km6A-3x0tA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		5 GLY A 465
VAL A 452
GLN A 453
ASN A 475
GLY A 472
 None
 1.32A 3km6A-4a0mA:
undetectable		 3km6A-4a0mA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 GLY A  82
TRP A 116
GLN A  96
ILE A  86
ASN A  78
 None
None
HEC  A 423 (-3.6A)
None
None
 1.24A 3km6A-4aalA:
undetectable		 3km6A-4aalA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		5 TYR A 276
GLY A 381
VAL A 239
ASN A 379
GLY A 195
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.28A 3km6A-4b98A:
undetectable		 3km6A-4b98A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		5 VAL A  61
GLY A  76
GLN A 246
ILE A 229
GLY A 260
 None
 1.11A 3km6A-4c1nA:
undetectable		 3km6A-4c1nA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 TYR A 227
VAL A 284
GLY A 360
ILE A 555
ASN A 316
 None
 1.30A 3km6A-4conA:
undetectable		 3km6A-4conA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 TYR A 244
VAL A 274
GLY A 242
VAL A 237
GLY A 159
 None
 1.32A 3km6A-4ecnA:
undetectable		 3km6A-4ecnA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY

(Staphylococcus
aureus) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		5 PHE A 287
VAL A 298
GLN A 266
ILE A 275
GLY A 333
 None
 1.27A 3km6A-4fdyA:
undetectable		 3km6A-4fdyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7a ETHANOLAMINE
UTILIZATION PROTEIN
EUTN/CARBOXYSOME
STRUCTURAL PROTEIN
CCML

(Rhodospirillum
rubrum) 		PF03319
(EutN_CcmL) 		5 VAL A   6
GLY A  50
VAL A  42
ASN A  51
GLY A   8
 None
 1.26A 3km6A-4i7aA:
undetectable		 3km6A-4i7aA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI

(Caulobacter
vibrioides) 		PF06230
(DUF1009) 		5 PHE A 270
VAL A 142
GLY A 268
ILE A 234
GLY A 140
 None
 1.33A 3km6A-4j6eA:
undetectable		 3km6A-4j6eA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7r ANAMORSIN

(Homo sapiens) 		PF08241
(Methyltransf_11) 		5 VAL A  92
GLY A  90
VAL A  53
GLN A  57
ILE A  71
 None
 1.34A 3km6A-4m7rA:
undetectable		 3km6A-4m7rA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqd DNA-ENTRY NUCLEASE
INHIBITOR

(Bacillus
subtilis) 		PF11033
(ComJ) 		5 TYR A 106
VAL A  82
VAL A  19
ASN A  85
GLY A  86
 None
 1.33A 3km6A-4mqdA:
undetectable		 3km6A-4mqdA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Streptococcus
pneumoniae) 		PF01070
(FMN_dh) 		5 TYR A 168
VAL A 141
GLY A 119
VAL A 174
ASN A 117
 None
None
None
None
FNR  A 404 (-3.0A)
 1.30A 3km6A-4n02A:
undetectable		 3km6A-4n02A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		5 TYR A 104
PHE A  59
VAL A  55
ILE A 188
GLY A 164
 None
 1.24A 3km6A-4n83A:
undetectable		 3km6A-4n83A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 TYR A  55
VAL A 267
GLY A  74
VAL A 133
GLY A 271
 None
 1.23A 3km6A-4ptfA:
undetectable		 3km6A-4ptfA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TYR A   8
VAL A  11
GLY A  13
TRP A  50
ILE A 116
 None
None
None
GSH  A 401 (-4.0A)
GSH  A 402 ( 4.5A)
 0.98A 3km6A-4q5nA:
25.4		 3km6A-4q5nA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3m 2-DEHYDROPANTOATE
2-REDUCTASE

(Staphylococcus
aureus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 TYR A  40
VAL A 126
VAL A  53
ILE A 117
GLY A  11
 None
None
None
None
NAP  A 500 (-3.1A)
 0.92A 3km6A-4s3mA:
undetectable		 3km6A-4s3mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN

(Haliangium
ochraceum) 		PF14497
(GST_C_3) 		5 TYR A   9
PHE A  10
VAL A  12
GLY A  14
TRP A  40
 None
 0.35A 3km6A-4w66A:
21.5		 3km6A-4w66A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Pseudomonas
aeruginosa) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 VAL B 333
GLY B 338
VAL B 367
ILE B 379
GLY B 373
 None
 1.29A 3km6A-4wj3B:
undetectable		 3km6A-4wj3B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmy INTELECTIN-1

(Homo sapiens) 		no annotation 5 TYR A 187
PHE A 238
VAL A 206
ILE A 266
ASN A 248
 None
 1.11A 3km6A-4wmyA:
undetectable		 3km6A-4wmyA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb4 ORANGE
CAROTENOID-BINDING
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF09150
(Carot_N) 		5 TYR A  98
PHE A 109
GLN A  72
ILE A  40
GLY A 108
 None
None
None
45D  A 201 (-3.5A)
45D  A 201 ( 4.4A)
 1.14A 3km6A-4xb4A:
undetectable		 3km6A-4xb4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Burkholderia
thailandensis) 		PF01128
(IspD) 		5 VAL A  54
GLY A  78
VAL A 106
ASN A  88
GLY A  89
 None
 1.18A 3km6A-4ys8A:
undetectable		 3km6A-4ys8A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		5 VAL A 358
GLY A 117
VAL A  72
ILE A 120
GLY A  81
 None
 1.14A 3km6A-4zxoA:
undetectable		 3km6A-4zxoA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d73 GLUTATHIONE
S-TRANSFERASE

(Wuchereria
bancrofti) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		6 TYR A   7
PHE A   8
GLY A  12
TRP A  38
ASN A 203
GLY A 204
 None
GSH  A 301 (-4.9A)
None
GSH  A 301 (-4.0A)
None
None
 0.39A 3km6A-5d73A:
30.7		 3km6A-5d73A:
41.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewo STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		5 TYR A 588
PHE A 582
VAL A 543
GLY A 586
GLY A 546
 None
 1.08A 3km6A-5ewoA:
undetectable		 3km6A-5ewoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEOSOME SUBUNIT
ALPHA TYPE 1,
PUTATIVE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 TYR F 116
PHE F 128
VAL F 130
GLY F 131
ILE F  72
 None
 1.30A 3km6A-5fmgF:
undetectable		 3km6A-5fmgF:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 PHE A 115
VAL A  69
GLY A  66
ILE A 189
GLY A 192
 None
 1.06A 3km6A-5gndA:
undetectable		 3km6A-5gndA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqn ALIPHATIC AMIDASE

(Nesterenkonia
sp. AN1) 		PF00795
(CN_hydrolase) 		5 VAL A  48
GLY A 204
VAL A  56
GLN A  60
GLY A  46
 None
 1.21A 3km6A-5jqnA:
undetectable		 3km6A-5jqnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 VAL A 179
GLY A 178
VAL A 219
ILE A  23
GLY A 232
 None
 1.33A 3km6A-5k1uA:
undetectable		 3km6A-5k1uA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 5 VAL B 368
GLY B 458
VAL B 236
ILE B 439
GLY B 371
 None
 1.26A 3km6A-5ltmB:
undetectable		 3km6A-5ltmB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 5 VAL A 189
GLY A 187
VAL A 169
GLN A 179
GLY A 165
 None
 1.32A 3km6A-5n4aA:
undetectable		 3km6A-5n4aA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN

(Homo sapiens) 		no annotation 5 VAL L  29
GLY L  30
VAL L 101
ASN L  71
GLY L  24
 None
 1.29A 3km6A-5ngvL:
undetectable		 3km6A-5ngvL:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh1 GAMMA S-CRYSTALLIN

(Gallus gallus) 		PF00030
(Crystall) 		5 TYR A 156
VAL A 131
GLY A 154
VAL A 137
GLN A 148
 None
 1.27A 3km6A-5vh1A:
undetectable		 3km6A-5vh1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwn TRIOSEPHOSPHATE
ISOMERASE

(Trichomonas
vaginalis) 		no annotation 5 VAL A 226
VAL A 239
ILE A 117
ASN A   9
GLY A   8
 None
 1.34A 3km6A-5vwnA:
undetectable		 3km6A-5vwnA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcc PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 5 TYR A 134
VAL A 157
GLY A 132
GLN A 125
GLY A  41
 None
 1.27A 3km6A-5xccA:
undetectable		 3km6A-5xccA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 TYR A 158
VAL A 265
GLY A 264
VAL A 473
GLY A 433
 None
 1.07A 3km6A-5yl7A:
undetectable		 3km6A-5yl7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 TYR A 441
VAL A 463
GLY A 439
GLN A 405
GLY A 359
 None
 1.27A 3km6A-5z24A:
undetectable		 3km6A-5z24A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amg CYTOCHROME P460

(Nitrosomonas
sp. AL212) 		no annotation 5 VAL A 103
GLY A 101
GLN A 159
ASN A  38
GLY A  40
 None
 1.28A 3km6A-6amgA:
undetectable		 3km6A-6amgA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 5 VAL A 375
GLY A 374
VAL A 284
GLN A 279
ASN A 373
 None
 1.28A 3km6A-6bk1A:
undetectable		 3km6A-6bk1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 5 VAL A 315
VAL A 363
GLN A 438
ILE A 175
GLY A 312
 None
None
None
None
FAD  A 601 (-3.3A)
 1.31A 3km6A-6em0A:
undetectable		 3km6A-6em0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 5 GLY A 281
VAL A 333
ILE A 261
ASN A 277
GLY A 276
 None
 1.28A 3km6A-6fhwA:
2.1		 3km6A-6fhwA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 5 TYR A 582
PHE A 465
GLY A 697
GLN A 475
GLY A 464
 None
 1.32A 3km6A-6fsaA:
undetectable		 3km6A-6fsaA:
undetectable