SIMILAR PATTERNS OF AMINO ACIDS FOR 3KL3_A_DHIA403_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		4 GLY A 133
TYR A 145
GLY A 169
ASP A   4
 None
 0.93A 3kl3A-1d2iA:
undetectable		 3kl3A-1d2iA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3a PENICILLIN AMIDASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		4 GLY A  30
TYR A  29
GLY A  99
ASP A  98
 None
 1.36A 3kl3A-1e3aA:
undetectable		 3kl3A-1e3aA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanothermobacter
thermautotrophicus) 		PF00296
(Bac_luciferase) 		4 GLY A  91
TYR A 149
GLY A 167
ASP A 166
 None
 1.09A 3kl3A-1f07A:
11.0		 3kl3A-1f07A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLY A  59
TYR A  58
GLY A  87
ASP A  97
 None
 0.70A 3kl3A-1gfnA:
undetectable		 3kl3A-1gfnA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzc ERYTHRINA
CRISTA-GALLI LECTIN

(Erythrina
crista-galli) 		PF00139
(Lectin_legB) 		4 GLY A 105
TYR A 106
GLY A 217
ASP A  46
 None
None
LAT  A1559 (-3.1A)
None
 1.04A 3kl3A-1gzcA:
undetectable		 3kl3A-1gzcA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 GLY A 109
TYR A 101
GLY A 106
ASP A 478
 None
 1.14A 3kl3A-1itkA:
undetectable		 3kl3A-1itkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 GLY A 306
TYR A 305
GLY A 267
ASP A 268
 NA  A 522 ( 4.3A)
None
None
None
 1.24A 3kl3A-1jedA:
undetectable		 3kl3A-1jedA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kec PENICILLIN ACYLASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		4 GLY A  30
TYR A  29
GLY A  99
ASP A  98
 None
 1.35A 3kl3A-1kecA:
undetectable		 3kl3A-1kecA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 GLY A 133
TYR A  81
GLY A 137
ASP A 140
 None
 1.34A 3kl3A-1krmA:
5.2		 3kl3A-1krmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)
IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 GLY L  51
TYR H 353
GLY H 355
ASP H 356
 None
 1.23A 3kl3A-1mfaL:
undetectable		 3kl3A-1mfaL:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osm OMPK36

(Klebsiella
pneumoniae) 		PF00267
(Porin_1) 		4 GLY A  59
TYR A  58
GLY A  87
ASP A  97
 None
 0.60A 3kl3A-1osmA:
undetectable		 3kl3A-1osmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pho PHOSPHOPORIN

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLY A  59
TYR A  58
GLY A  87
ASP A  97
 None
 0.69A 3kl3A-1phoA:
undetectable		 3kl3A-1phoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A  99
TYR A  98
GLY A 227
ASP A 226
 None
 1.12A 3kl3A-1ud3A:
5.6		 3kl3A-1ud3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl8 GLUCONATE
5-DEHYDROGENASE

(Thermotoga
maritima) 		PF13561
(adh_short_C2) 		4 GLY A 191
TYR A 193
GLY A 221
ASP A 225
 None
 1.23A 3kl3A-1vl8A:
undetectable		 3kl3A-1vl8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 101
TYR A 100
GLY A 232
ASP A 231
 None
 1.13A 3kl3A-1w9xA:
13.8		 3kl3A-1w9xA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE

(Methanosarcina
barkeri) 		PF00296
(Bac_luciferase) 		4 GLY A  91
TYR A 154
GLY A 172
ASP A 171
 None
 1.15A 3kl3A-1z69A:
10.6		 3kl3A-1z69A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbm HYPOTHETICAL PROTEIN
AF1704

(Archaeoglobus
fulgidus) 		PF02621
(VitK2_biosynth) 		4 GLY A  81
TYR A  80
GLY A  79
ASP A  78
 None
 1.07A 3kl3A-1zbmA:
undetectable		 3kl3A-1zbmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE

(Legionella
pneumophila) 		PF05761
(5_nucleotid) 		4 GLY A  21
TYR A 300
GLY A 302
ASP A  23
 None
 0.85A 3kl3A-2bdeA:
undetectable		 3kl3A-2bdeA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 GLY A 188
TYR A 455
GLY A 236
ASP A 235
 None
 1.13A 3kl3A-2d1gA:
undetectable		 3kl3A-2d1gA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg0 DRP35

(Staphylococcus
aureus) 		PF08450
(SGL) 		4 GLY A 106
TYR A 104
GLY A 113
ASP A 130
 None
 0.99A 3kl3A-2dg0A:
undetectable		 3kl3A-2dg0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Aquifex
aeolicus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A 173
TYR A 174
GLY A 229
ASP A 228
 None
 1.24A 3kl3A-2ep7A:
undetectable		 3kl3A-2ep7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 GLY H 406
TYR H 407
GLY H 311
ASP H 498
 None
 1.19A 3kl3A-2fhgH:
undetectable		 3kl3A-2fhgH:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE

(Bacillus
halodurans) 		PF02608
(Bmp) 		4 GLY A 107
TYR A 108
GLY A 141
ASP A 140
 None
 0.86A 3kl3A-2hqbA:
undetectable		 3kl3A-2hqbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		4 GLY A 117
TYR A  81
GLY A 121
ASP A 124
 None
 1.06A 3kl3A-2hruA:
undetectable		 3kl3A-2hruA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 GLY A 201
TYR A 248
GLY A 218
ASP A 220
 None
 1.33A 3kl3A-2i44A:
undetectable		 3kl3A-2i44A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLY A  54
TYR A  53
GLY A  79
ASP A  89
 None
 0.69A 3kl3A-2j1nA:
undetectable		 3kl3A-2j1nA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jay PROTEASOME

(Mycobacterium
tuberculosis) 		PF00227
(Proteasome) 		4 GLY A 163
TYR A 164
GLY A  68
ASP A 255
 None
 1.20A 3kl3A-2jayA:
undetectable		 3kl3A-2jayA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 475
TYR A 457
GLY A 429
ASP A 557
 None
 1.17A 3kl3A-2oaeA:
undetectable		 3kl3A-2oaeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 GLY A  58
TYR A  86
GLY A  84
ASP A  83
 GLY  A  58 ( 0.0A)
TYR  A  86 ( 1.3A)
GLY  A  84 ( 0.0A)
ASP  A  83 ( 0.6A)
 1.06A 3kl3A-2ogsA:
2.2		 3kl3A-2ogsA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLY A  60
TYR A  50
GLY A  62
ASP A  74
 GOL  A3001 (-3.3A)
None
None
None
 1.34A 3kl3A-2okxA:
undetectable		 3kl3A-2okxA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otm HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF14588
(YjgF_endoribonc) 		4 GLY A  64
TYR A  65
GLY A 114
ASP A 113
 None
 0.93A 3kl3A-2otmA:
undetectable		 3kl3A-2otmA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA

(Mycobacterium
tuberculosis) 		PF16708
(LppA) 		4 GLY A 150
TYR A 173
GLY A 172
ASP A 190
 None
 1.29A 3kl3A-2v7sA:
undetectable		 3kl3A-2v7sA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 GLY A 286
TYR A 285
GLY A 331
ASP A 330
 None
 1.06A 3kl3A-2w92A:
4.8		 3kl3A-2w92A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLY A 342
TYR A 344
GLY A 360
ASP A 373
 None
 1.05A 3kl3A-2waeA:
undetectable		 3kl3A-2waeA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjr PROBABLE
N-ACETYLNEURAMINIC
ACID OUTER MEMBRANE
CHANNEL PROTEIN NANC

(Escherichia
coli) 		PF06178
(KdgM) 		4 GLY A 103
TYR A 133
GLY A 132
ASP A 131
 OCT  A1219 (-4.5A)
None
OCT  A1219 ( 4.0A)
None
 1.25A 3kl3A-2wjrA:
undetectable		 3kl3A-2wjrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLY A  54
TYR A  53
GLY A  79
ASP A  89
 None
 0.70A 3kl3A-2xe5A:
undetectable		 3kl3A-2xe5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		4 GLY A 612
TYR A 613
GLY A 614
ASP A 685
 None
 1.32A 3kl3A-2yhgA:
undetectable		 3kl3A-2yhgA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab1 FERREDOXIN--NADP
REDUCTASE

(Chlorobaculum
tepidum) 		PF07992
(Pyr_redox_2) 		4 GLY A 106
TYR A 326
GLY A 292
ASP A 291
 None
 1.34A 3kl3A-3ab1A:
undetectable		 3kl3A-3ab1A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		4 GLY A 104
TYR A 173
GLY A 191
ASP A 190
 None
 1.01A 3kl3A-3b4yA:
10.4		 3kl3A-3b4yA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c26 PUTATIVE
ACETYLTRANSFERASE
TA0821

(Thermoplasma
acidophilum) 		PF00583
(Acetyltransf_1) 		4 GLY A 201
TYR A 167
GLY A 169
ASP A 220
 None
 1.22A 3kl3A-3c26A:
undetectable		 3kl3A-3c26A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		4 GLY A 374
TYR A 373
GLY A 388
ASP A 402
 None
 0.73A 3kl3A-3fipA:
undetectable		 3kl3A-3fipA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 4 GLY A 235
TYR A 234
GLY A 198
ASP A 199
 None
 1.35A 3kl3A-3gjyA:
undetectable		 3kl3A-3gjyA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv0 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Agrobacterium
fabrum) 		PF13377
(Peripla_BP_3) 		4 GLY A 206
TYR A 174
GLY A 210
ASP A 213
 None
 1.13A 3kl3A-3gv0A:
undetectable		 3kl3A-3gv0A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 GLY A 233
TYR A 396
GLY A 237
ASP A 240
 None
 1.15A 3kl3A-3ifsA:
undetectable		 3kl3A-3ifsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		4 GLY A 384
TYR A 394
GLY A 396
ASP A 382
 None
 1.33A 3kl3A-3ivrA:
undetectable		 3kl3A-3ivrA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		4 GLY A 300
TYR A 301
GLY A 321
ASP A 322
 None
 0.15A 3kl3A-3kl0A:
69.3		 3kl3A-3kl0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld9 THYMIDYLATE KINASE

(Ehrlichia
chaffeensis) 		PF02223
(Thymidylate_kin) 		4 GLY A 105
TYR A 104
GLY A 161
ASP A 160
 None
 0.94A 3kl3A-3ld9A:
undetectable		 3kl3A-3ld9A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		4 GLY A 107
TYR A 105
GLY A 197
ASP A 183
 None
BTB  A   1 (-3.6A)
None
None
 1.13A 3kl3A-3li9A:
undetectable		 3kl3A-3li9A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnl UPF0135 PROTEIN
SA1388

(Staphylococcus
aureus) 		PF01784
(NIF3) 		4 GLY A  61
TYR A  62
GLY A  42
ASP A 356
 None
 0.79A 3kl3A-3lnlA:
undetectable		 3kl3A-3lnlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obe SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 GLY A 298
TYR A 300
GLY A  49
ASP A  77
 EOH  A 402 (-3.4A)
EOH  A 402 (-4.0A)
EOH  A 402 (-4.2A)
EOH  A 402 (-3.8A)
 1.09A 3kl3A-3obeA:
11.4		 3kl3A-3obeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odj RHOMBOID PROTEASE
GLPG

(Haemophilus
influenzae) 		PF01694
(Rhomboid) 		4 GLY A 176
TYR A 125
GLY A 180
ASP A 183
 None
 1.31A 3kl3A-3odjA:
undetectable		 3kl3A-3odjA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		4 GLY A 367
TYR A 366
GLY A 381
ASP A 395
 None
 0.75A 3kl3A-3ohnA:
undetectable		 3kl3A-3ohnA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 GLY A 324
TYR A 323
GLY A 322
ASP A 284
 None
None
None
ZN  A 343 (-2.7A)
 1.24A 3kl3A-3q9cA:
undetectable		 3kl3A-3q9cA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLY A  89
TYR A  83
GLY A 255
ASP A 179
 None
 1.35A 3kl3A-3rv2A:
undetectable		 3kl3A-3rv2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upg OUTER MEMBRANE
PROTEIN C

(Salmonella
enterica) 		PF00267
(Porin_1) 		4 GLY A  54
TYR A  53
GLY A  79
ASP A  89
 None
 0.76A 3kl3A-3upgA:
undetectable		 3kl3A-3upgA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 GLY A 153
TYR A 146
GLY A 151
ASP A 531
 None
 1.30A 3kl3A-3ut2A:
undetectable		 3kl3A-3ut2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 GLY A 154
TYR A 146
GLY A 151
ASP A 531
 None
 1.17A 3kl3A-3ut2A:
undetectable		 3kl3A-3ut2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		4 GLY A 107
TYR A 100
GLY A 105
ASP A 477
 NA  A 805 (-4.0A)
None
NA  A 805 (-4.7A)
None
 1.36A 3kl3A-3wxoA:
undetectable		 3kl3A-3wxoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		4 GLY A 108
TYR A 100
GLY A 105
ASP A 477
 NA  A 805 ( 4.8A)
None
NA  A 805 (-4.7A)
None
 1.14A 3kl3A-3wxoA:
undetectable		 3kl3A-3wxoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9

(Homo sapiens) 		PF07525
(SOCS_box)
PF12796
(Ank_2) 		4 GLY A 168
TYR A 172
GLY A 196
ASP A 200
 None
 1.35A 3kl3A-3zkjA:
undetectable		 3kl3A-3zkjA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Halobacterium
salinarum) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 GLY A 149
TYR A 148
GLY A 224
ASP A 223
 None
 1.18A 3kl3A-4af1A:
undetectable		 3kl3A-4af1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		4 GLY A 151
TYR A 153
GLY A 227
ASP A 308
 None
 1.07A 3kl3A-4b2gA:
undetectable		 3kl3A-4b2gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 GLY A 121
TYR A 113
GLY A 118
ASP A 487
 None
 1.13A 3kl3A-4c51A:
undetectable		 3kl3A-4c51A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmw DITERPENE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A 122
TYR A 121
GLY A 159
ASP A 214
 None
 1.03A 3kl3A-4cmwA:
undetectable		 3kl3A-4cmwA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebg UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF14729
(DUF4467) 		4 GLY A   0
TYR A  25
GLY A  67
ASP A  66
 EDO  A 201 (-3.4A)
EDO  A 201 (-4.9A)
None
None
 1.19A 3kl3A-4ebgA:
undetectable		 3kl3A-4ebgA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 GLY A  34
TYR A  40
GLY A  37
ASP A 227
 None
 1.24A 3kl3A-4eudA:
undetectable		 3kl3A-4eudA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fmv GLUCURONOARABINOXYLA
N
ENDO-1,4-BETA-XYLANA
SE

([Clostridium]
papyrosolvens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 GLY A 297
TYR A 298
GLY A 318
ASP A 319
 None
 0.17A 3kl3A-4fmvA:
57.0		 3kl3A-4fmvA:
55.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		4 GLY A 243
TYR A 242
GLY A 265
ASP A 264
 None
None
None
PEG  A 502 ( 3.5A)
 1.14A 3kl3A-4h09A:
undetectable		 3kl3A-4h09A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 GLY A 182
TYR A 184
GLY A 265
ASP A 310
 None
 1.33A 3kl3A-4j1sA:
undetectable		 3kl3A-4j1sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		4 GLY D 367
TYR D 366
GLY D 381
ASP D 395
 None
 0.99A 3kl3A-4j3oD:
undetectable		 3kl3A-4j3oD:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A 419
TYR A 418
GLY A 336
ASP A 337
 None
 1.11A 3kl3A-4l7tA:
undetectable		 3kl3A-4l7tA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mee DIFFUSE ADHERENCE
ADHESIN

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 GLY A1086
TYR A1085
GLY A1052
ASP A1037
 None
 0.87A 3kl3A-4meeA:
undetectable		 3kl3A-4meeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		4 GLY A  72
TYR A  71
GLY A  69
ASP A 140
 None
 1.35A 3kl3A-4p9nA:
undetectable		 3kl3A-4p9nA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLY A 298
TYR A 297
GLY A 190
ASP A 186
 None
None
None
GOL  A 703 (-4.9A)
 0.96A 3kl3A-4pf1A:
undetectable		 3kl3A-4pf1A:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 GLY A 299
TYR A 300
GLY A 320
ASP A 321
 None
 0.21A 3kl3A-4qawA:
65.8		 3kl3A-4qawA:
57.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 GLY A 532
TYR A 533
GLY A 432
ASP A 497
 None
 1.32A 3kl3A-4r1dA:
undetectable		 3kl3A-4r1dA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE

(Aliivibrio
salmonicida) 		PF00701
(DHDPS) 		4 GLY A 133
TYR A 135
GLY A 164
ASP A 187
 None
 1.17A 3kl3A-5afdA:
9.3		 3kl3A-5afdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		4 GLY A 153
TYR A 154
GLY A 443
ASP A 444
 None
 1.31A 3kl3A-5axhA:
6.7		 3kl3A-5axhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		4 GLY A 273
TYR A 275
GLY A 264
ASP A 218
 None
 0.98A 3kl3A-5cd6A:
undetectable		 3kl3A-5cd6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqb DITRANS,POLYCIS-UNDE
CAPRENYL-DIPHOSPHATE
SYNTHASE
((2E,6E)-FARNESYL-DI
PHOSPHATE SPECIFIC)

(Escherichia
coli) 		PF01255
(Prenyltransf) 		4 GLY A 111
TYR A 145
GLY A 146
ASP A 150
 None
 1.05A 3kl3A-5cqbA:
undetectable		 3kl3A-5cqbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY L  96
TYR L 105
GLY L  94
ASP L  35
 None
 1.07A 3kl3A-5eorL:
undetectable		 3kl3A-5eorL:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frv POSITIVE
PHENOL-DEGRADATIVE
GENE REGULATOR

(Cupriavidus
necator) 		PF02830
(V4R)
PF06505
(XylR_N) 		4 GLY A  71
TYR A 157
GLY A  75
ASP A  78
 None
PCR  A1210 ( 4.8A)
None
None
 1.23A 3kl3A-5frvA:
undetectable		 3kl3A-5frvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvn OMPC PORIN

(Enterobacter
cloacae) 		PF00267
(Porin_1) 		4 GLY A  54
TYR A  53
GLY A  79
ASP A  89
 None
 0.68A 3kl3A-5fvnA:
undetectable		 3kl3A-5fvnA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN

(Lavandula
lanata) 		PF01255
(Prenyltransf) 		4 GLY A 163
TYR A 197
GLY A 198
ASP A 202
 None
 1.05A 3kl3A-5hc8A:
2.3		 3kl3A-5hc8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Solanum
habrochaites) 		PF01255
(Prenyltransf) 		4 GLY A 167
TYR A 201
GLY A 202
ASP A 206
 None
 1.09A 3kl3A-5hxtA:
2.6		 3kl3A-5hxtA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		4 GLY A 140
TYR A 165
GLY A 134
ASP A 133
 None
None
None
BGC  A 604 (-2.6A)
 0.83A 3kl3A-5j7zA:
9.2		 3kl3A-5j7zA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbe MOPR

(Acinetobacter
calcoaceticus) 		PF02830
(V4R)
PF06505
(XylR_N) 		4 GLY A  75
TYR A 161
GLY A  79
ASP A  82
 None
IPH  A 602 ( 4.8A)
None
None
 1.22A 3kl3A-5kbeA:
undetectable		 3kl3A-5kbeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 GLY A 153
TYR A 155
GLY A 229
ASP A 310
 None
 1.18A 3kl3A-5kodA:
undetectable		 3kl3A-5kodA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 GLY A 124
TYR A 117
GLY A 122
ASP A 495
 CL  A 803 ( 4.0A)
None
NA  A 802 (-4.7A)
None
 1.36A 3kl3A-5kqiA:
undetectable		 3kl3A-5kqiA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 GLY A 125
TYR A 117
GLY A 122
ASP A 495
 NA  A 802 ( 4.8A)
None
NA  A 802 (-4.7A)
None
 1.11A 3kl3A-5kqiA:
undetectable		 3kl3A-5kqiA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 GLY B 249
TYR B 234
GLY B 176
ASP B 232
 None
 1.23A 3kl3A-5lxzB:
undetectable		 3kl3A-5lxzB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mt2 BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 123
TYR A 150
GLY A 152
ASP A 118
 None
 0.94A 3kl3A-5mt2A:
undetectable		 3kl3A-5mt2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o77 OMPK35

(Klebsiella
pneumoniae) 		no annotation 4 GLY A  55
TYR A  54
GLY A  80
ASP A  90
 None
C8E  A 404 (-3.4A)
None
None
 0.67A 3kl3A-5o77A:
undetectable		 3kl3A-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9c OSMOPORIN OMP36

(Klebsiella
aerogenes) 		no annotation 4 GLY C  54
TYR C  53
GLY C  80
ASP C  90
 None
 0.66A 3kl3A-5o9cC:
undetectable		 3kl3A-5o9cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN
CAPSID PROTEIN

(Enterovirus E;
Enterovirus E) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 GLY A 256
TYR A 258
GLY B 159
ASP B 158
 None
 1.29A 3kl3A-5osnA:
undetectable		 3kl3A-5osnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		no annotation 4 GLY B 311
TYR B 273
GLY B 275
ASP B 276
 None
 1.19A 3kl3A-5wy8B:
undetectable		 3kl3A-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF12680
(SnoaL_2) 		4 GLY A 258
TYR A 262
GLY A 261
ASP A 260
 None
 1.32A 3kl3A-5xe7A:
undetectable		 3kl3A-5xe7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 4 GLY A 448
TYR A 450
GLY A 445
ASP A 330
 None
 1.30A 3kl3A-6bvgA:
undetectable		 3kl3A-6bvgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2x PROTEIN TYROSINE
KINASE A

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A 261
TYR A 262
GLY A 263
ASP A 266
 None
 1.13A 3kl3A-6f2xA:
undetectable		 3kl3A-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g47 FIBER-1

(Human
mastadenovirus
G) 		no annotation 4 GLY A 259
TYR A 336
GLY A 335
ASP A 257
 None
 1.23A 3kl3A-6g47A:
undetectable		 3kl3A-6g47A:
undetectable