SIMILAR PATTERNS OF AMINO ACIDS FOR 3KK6_B_CELB1701_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 VAL A 454
SER A 125
LEU A 134
ALA A 108
 None
 0.71A 3kk6B-1ao0A:
0.0		 3kk6B-1ao0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 VAL A 332
LEU A 100
ILE A  92
ALA A  60
 None
 0.92A 3kk6B-1as4A:
0.0		 3kk6B-1as4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		4 SER A 281
LEU A 263
ILE A 288
LEU A  84
 None
 0.89A 3kk6B-1axnA:
0.0		 3kk6B-1axnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		4 VAL A 163
ILE A 293
ALA A  61
LEU A 167
 None
 0.82A 3kk6B-1b65A:
0.0		 3kk6B-1b65A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c41 LUMAZINE SYNTHASE

(Magnaporthe
grisea) 		PF00885
(DMRL_synthase) 		4 LEU A 114
ILE A  64
ALA A  72
LEU A  75
 None
 0.88A 3kk6B-1c41A:
undetectable		 3kk6B-1c41A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		4 VAL A  57
LEU A   8
ILE A 182
LEU A  44
 None
 0.89A 3kk6B-1c8uA:
0.0		 3kk6B-1c8uA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 SER A 302
LEU A 138
ILE A 298
ALA A 248
 None
 0.85A 3kk6B-1dcnA:
0.0		 3kk6B-1dcnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 113
SER A 309
LEU A 328
ILE A 287
ALA A 314
 None
 1.27A 3kk6B-1e8cA:
0.0		 3kk6B-1e8cA:
19.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 116
SER A 353
LEU A 384
ILE A 517
ALA A 527
LEU A 531
 None
None
None
None
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.48A 3kk6B-1ebvA:
59.6		 3kk6B-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3u TRANSCRIPTION
INITIATION FACTOR
IIF, ALPHA SUBUNIT
TRANSCRIPTION
INITIATION FACTOR
IIF, BETA SUBUNIT

(Homo sapiens) 		PF02270
(TFIIF_beta)
PF05793
(TFIIF_alpha) 		4 VAL A  54
ILE B 126
ALA A 114
LEU A  85
 None
 0.82A 3kk6B-1f3uA:
0.0		 3kk6B-1f3uA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 VAL A 150
ILE A 340
ALA A 173
LEU A 176
 None
 0.84A 3kk6B-1fcdA:
undetectable		 3kk6B-1fcdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		5 SER A  60
LEU A 261
ILE A 292
ALA A 299
LEU A 302
 None
 1.24A 3kk6B-1gq7A:
undetectable		 3kk6B-1gq7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gux RETINOBLASTOMA
PROTEIN

(Homo sapiens) 		PF01858
(RB_A) 		4 LEU A 542
ILE A 388
ALA A 490
LEU A 491
 None
 0.85A 3kk6B-1guxA:
2.6		 3kk6B-1guxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13561
(adh_short_C2) 		4 VAL A  70
LEU A  27
ALA A  34
LEU A  10
 None
 0.84A 3kk6B-1hxhA:
undetectable		 3kk6B-1hxhA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 VAL A 269
SER A 260
LEU A 193
LEU A 267
 None
 0.88A 3kk6B-1i5pA:
undetectable		 3kk6B-1i5pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij9 VASCULAR CELL
ADHESION PROTEIN 1

(Homo sapiens) 		PF05790
(C2-set)
PF07679
(I-set) 		5 VAL A 118
SER A 114
ILE A  97
ALA A 173
LEU A 124
 None
 1.30A 3kk6B-1ij9A:
undetectable		 3kk6B-1ij9A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		5 VAL C 498
LEU C 576
ILE C 387
ALA C 533
LEU C 538
 None
 1.32A 3kk6B-1j3jC:
undetectable		 3kk6B-1j3jC:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfr LIPASE

(Streptomyces
exfoliatus) 		PF03403
(PAF-AH_p_II) 		4 VAL A  57
SER A 223
LEU A 197
ALA A 149
 None
 0.88A 3kk6B-1jfrA:
undetectable		 3kk6B-1jfrA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 VAL A 231
ILE A  33
ALA A 198
LEU A 236
 None
 0.81A 3kk6B-1ji0A:
0.4		 3kk6B-1ji0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 VAL A 195
ILE A 260
ALA A 185
LEU A 206
 None
 0.71A 3kk6B-1js6A:
undetectable		 3kk6B-1js6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A 225
LEU A 238
ILE A 230
ALA A 195
 None
 0.87A 3kk6B-1k4qA:
undetectable		 3kk6B-1k4qA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 VAL A 142
SER A  85
ALA A  90
LEU A  65
 None
SAH  A 900 ( 4.4A)
None
None
 0.74A 3kk6B-1kpiA:
undetectable		 3kk6B-1kpiA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 LEU A  66
ILE A  57
ALA A  39
LEU A  40
 None
 0.90A 3kk6B-1kywA:
undetectable		 3kk6B-1kywA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		4 VAL A   7
LEU A 406
ILE A  27
LEU A 352
 None
 0.77A 3kk6B-1lwdA:
undetectable		 3kk6B-1lwdA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 VAL A 481
LEU A 448
ILE A 390
ALA A 409
LEU A 476
 None
 1.40A 3kk6B-1m2wA:
undetectable		 3kk6B-1m2wA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1njh PROTEIN YOJF

(Bacillus
subtilis) 		PF08830
(DUF1806) 		4 VAL A  67
SER A  12
ALA A  57
LEU A  69
 None
 0.83A 3kk6B-1njhA:
undetectable		 3kk6B-1njhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		5 VAL A  93
SER A 209
LEU A 176
ILE A 207
LEU A  97
 None
None
None
None
MLG  A 709 ( 4.9A)
 1.31A 3kk6B-1o5wA:
undetectable		 3kk6B-1o5wA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00285
(Citrate_synt) 		4 LEU A 210
ILE A  83
ALA A 332
LEU A 333
 None
 0.88A 3kk6B-1o7xA:
undetectable		 3kk6B-1o7xA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		4 SER A 295
LEU A 282
ALA A 271
LEU A 272
 None
 0.67A 3kk6B-1opeA:
undetectable		 3kk6B-1opeA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110

(Staphylococcus
aureus) 		PF03180
(Lipoprotein_9) 		4 SER A 147
LEU A 164
ALA A 152
LEU A 121
 None
 0.85A 3kk6B-1p99A:
undetectable		 3kk6B-1p99A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		5 VAL A  89
SER A 110
LEU A  10
ALA A  76
LEU A  70
 None
 1.49A 3kk6B-1pjqA:
undetectable		 3kk6B-1pjqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		5 VAL A 169
SER A 212
LEU A  47
ILE A 226
LEU A 203
 None
 1.43A 3kk6B-1pn4A:
undetectable		 3kk6B-1pn4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 VAL A  59
LEU A  30
ILE A  22
ALA A 120
LEU A 121
 None
 1.18A 3kk6B-1qapA:
undetectable		 3kk6B-1qapA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		5 VAL A  58
LEU A  16
ILE A  45
ALA A 402
LEU A 407
 None
 1.49A 3kk6B-1qguA:
undetectable		 3kk6B-1qguA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo4 PEROXIDASE

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		5 VAL A  80
LEU A 288
ILE A 285
ALA A  51
LEU A  54
 None
 1.42A 3kk6B-1qo4A:
undetectable		 3kk6B-1qo4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 VAL A  31
LEU A  60
ILE A 199
ALA A 134
 None
 0.91A 3kk6B-1r6mA:
undetectable		 3kk6B-1r6mA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		4 VAL A 218
LEU A  86
ILE A  93
ALA A 113
 None
 0.84A 3kk6B-1ru3A:
undetectable		 3kk6B-1ru3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		5 VAL A 148
LEU A 288
ILE A 279
ALA A 194
LEU A 198
 None
 1.07A 3kk6B-1tdhA:
undetectable		 3kk6B-1tdhA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL B 342
SER B 184
ILE B 144
ALA B 232
 None
 0.83A 3kk6B-1tqyB:
undetectable		 3kk6B-1tqyB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 VAL A  80
LEU A 343
ALA A  94
LEU A  98
 None
 0.91A 3kk6B-1tuoA:
undetectable		 3kk6B-1tuoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhw PLECKSTRIN

(Mus musculus) 		PF00610
(DEP) 		4 SER A   5
LEU A  52
ALA A  10
LEU A  13
 None
 0.89A 3kk6B-1uhwA:
undetectable		 3kk6B-1uhwA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		5 VAL A 143
LEU A  91
ILE A 346
ALA A 199
LEU A 194
 None
 1.39A 3kk6B-1up2A:
undetectable		 3kk6B-1up2A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 VAL A 401
LEU A 161
ILE A 115
ALA A 444
 None
 0.80A 3kk6B-1vcjA:
undetectable		 3kk6B-1vcjA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 VAL A  83
ILE A  18
ALA A  96
LEU A 113
 VAL  A  83 ( 0.6A)
ILE  A  18 ( 0.7A)
ALA  A  96 ( 0.0A)
LEU  A 113 ( 0.6A)
 0.84A 3kk6B-1wqaA:
undetectable		 3kk6B-1wqaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 VAL A 215
LEU A  92
ALA A 184
LEU A 188
 None
 0.88A 3kk6B-1wzcA:
undetectable		 3kk6B-1wzcA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 SER A 148
LEU A 204
ILE A 153
ALA A 166
 None
 0.91A 3kk6B-1x8vA:
undetectable		 3kk6B-1x8vA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 VAL A 276
LEU A 521
ALA A 321
LEU A 322
 None
 0.91A 3kk6B-1x9nA:
undetectable		 3kk6B-1x9nA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 SER A 538
LEU A 508
ILE A 536
ALA A 519
 None
 0.88A 3kk6B-1xc6A:
0.6		 3kk6B-1xc6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		5 VAL A 297
LEU A 459
ILE A 389
ALA A 363
LEU A 294
 None
 1.43A 3kk6B-1ya0A:
undetectable		 3kk6B-1ya0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 VAL A  34
LEU A 152
ILE A  59
ALA A  16
LEU A  38
 None
 1.41A 3kk6B-1yb4A:
undetectable		 3kk6B-1yb4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01048
(PNP_UDP_1) 		5 VAL A 158
LEU A  30
ILE A  79
ALA A 204
LEU A 206
 None
 1.29A 3kk6B-1ybfA:
undetectable		 3kk6B-1ybfA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		4 VAL A  11
ILE A 482
ALA A  23
LEU A  27
 None
 0.78A 3kk6B-1yy5A:
undetectable		 3kk6B-1yy5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 VAL A 637
SER A 538
ILE A 423
LEU A 635
 None
 0.91A 3kk6B-1z45A:
undetectable		 3kk6B-1z45A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		4 VAL A   4
LEU A 161
ALA A 123
LEU A   8
 None
 0.76A 3kk6B-1zchA:
undetectable		 3kk6B-1zchA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A  71
LEU A 116
ILE A 126
ALA A  90
LEU A  66
 None
 1.39A 3kk6B-1zh8A:
undetectable		 3kk6B-1zh8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		4 VAL A  52
LEU A 158
ILE A  14
LEU A  32
 None
 0.89A 3kk6B-1zl0A:
undetectable		 3kk6B-1zl0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 VAL A 424
LEU A 144
ILE A  46
ALA A 226
LEU A 443
 None
 0.83A 3kk6B-2a2dA:
0.0		 3kk6B-2a2dA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		4 VAL A 119
SER A 167
LEU A  10
ALA A 153
 None
 0.89A 3kk6B-2a6pA:
undetectable		 3kk6B-2a6pA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 LEU B  25
ILE B 466
ALA B 174
LEU B 171
 None
 0.79A 3kk6B-2amcB:
undetectable		 3kk6B-2amcB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 VAL A 211
SER A 266
LEU A 131
LEU A 161
 None
 0.64A 3kk6B-2b3bA:
undetectable		 3kk6B-2b3bA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 SER A 553
LEU A 494
ALA A 559
LEU A 586
 None
 0.90A 3kk6B-2b3xA:
undetectable		 3kk6B-2b3xA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		4 VAL A  90
LEU A  28
ALA A 186
LEU A  94
 MC3  A 266 (-4.8A)
None
None
MC3  A 266 (-4.6A)
 0.88A 3kk6B-2b6oA:
undetectable		 3kk6B-2b6oA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		5 SER A 128
LEU A 136
ILE A 131
ALA A 262
LEU A 266
 None
 1.26A 3kk6B-2bdwA:
undetectable		 3kk6B-2bdwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 VAL A 101
LEU A 527
ILE A  92
ALA A 121
LEU A 500
 None
 1.39A 3kk6B-2cw7A:
undetectable		 3kk6B-2cw7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE

(Thermus
thermophilus) 		PF05067
(Mn_catalase) 		4 VAL A 125
LEU A  12
ALA A  78
LEU A  30
 None
 0.88A 3kk6B-2cwlA:
undetectable		 3kk6B-2cwlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36

(Canis lupus) 		PF03388
(Lectin_leg-like) 		5 VAL A 147
SER A 178
LEU A 247
ILE A 240
ALA A 158
 None
 1.41A 3kk6B-2dupA:
undetectable		 3kk6B-2dupA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 VAL A  82
ILE A 210
ALA A 255
LEU A  84
 None
 0.81A 3kk6B-2dwsA:
undetectable		 3kk6B-2dwsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A  79
ILE A  63
ALA A  73
LEU A 303
 None
 0.66A 3kk6B-2eklA:
undetectable		 3kk6B-2eklA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 VAL A   7
LEU A 126
ALA A  55
LEU A  11
 None
 0.91A 3kk6B-2fbqA:
undetectable		 3kk6B-2fbqA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvt CONSERVED
HYPOTHETICAL PROTEIN

(Rhodopseudomonas
palustris) 		PF04430
(DUF498) 		4 VAL A  61
ILE A  16
ALA A 120
LEU A  71
 None
 0.91A 3kk6B-2fvtA:
undetectable		 3kk6B-2fvtA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		5 VAL A  57
LEU A 360
ILE A   5
ALA A 146
LEU A  37
 None
 1.36A 3kk6B-2g85A:
undetectable		 3kk6B-2g85A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 VAL A 133
LEU A 168
ILE A 175
ALA A 136
LEU A 156
 None
 1.36A 3kk6B-2gahA:
undetectable		 3kk6B-2gahA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		4 LEU A 180
ILE A 187
ALA A 333
LEU A 266
 None
 0.90A 3kk6B-2gh9A:
undetectable		 3kk6B-2gh9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00121
(TIM) 		4 VAL A   4
ILE A 100
ALA A 136
LEU A 174
 None
 0.84A 3kk6B-2h6rA:
undetectable		 3kk6B-2h6rA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		5 VAL A  54
SER A 264
LEU A 314
ALA A  20
LEU A  52
 None
 1.46A 3kk6B-2h8xA:
undetectable		 3kk6B-2h8xA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 VAL A 271
ILE A 431
ALA A 549
LEU A 273
 None
 0.91A 3kk6B-2hnhA:
undetectable		 3kk6B-2hnhA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 8

(Saccharomyces
cerevisiae) 		PF09637
(Med18)
no annotation 		4 VAL I 198
SER B   6
LEU B  23
LEU B 252
 None
 0.90A 3kk6B-2hzsI:
undetectable		 3kk6B-2hzsI:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		4 LEU A 208
ILE A 358
ALA A 185
LEU A 181
 None
 0.91A 3kk6B-2ibpA:
0.4		 3kk6B-2ibpA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 VAL A1120
ILE A1057
ALA A1074
LEU A1079
 None
 0.92A 3kk6B-2ix8A:
undetectable		 3kk6B-2ix8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ke7 ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00536
(SAM_1) 		4 VAL A 840
SER A 822
ALA A 870
LEU A 874
 None
 0.78A 3kk6B-2ke7A:
undetectable		 3kk6B-2ke7A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 SER A 221
LEU A 127
ALA A 167
LEU A 169
 None
 0.90A 3kk6B-2m56A:
0.0		 3kk6B-2m56A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mx9 MINOR AMPULLATE
SPIDROIN

(Araneus
ventricosus) 		PF16763
(Spidroin_N) 		4 LEU A  22
ILE A   8
ALA A  71
LEU A 119
 None
 0.89A 3kk6B-2mx9A:
undetectable		 3kk6B-2mx9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nli LACTATE OXIDASE

(Aerococcus
viridans) 		PF01070
(FMN_dh) 		4 VAL A 112
ILE A  41
ALA A 334
LEU A 338
 None
FMN  A1375 ( 4.3A)
None
None
 0.85A 3kk6B-2nliA:
undetectable		 3kk6B-2nliA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		4 VAL A  87
LEU A  49
ILE A 126
ALA A 198
 None
 0.87A 3kk6B-2o78A:
0.0		 3kk6B-2o78A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		5 VAL A 343
SER A 188
ILE A 190
ALA A 128
LEU A 124
 None
 1.32A 3kk6B-2oewA:
undetectable		 3kk6B-2oewA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		4 VAL A 240
SER A 224
ALA A 256
LEU A 260
 None
 0.88A 3kk6B-2olaA:
undetectable		 3kk6B-2olaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozh HYPOTHETICAL PROTEIN
XCC2953

(Xanthomonas
campestris) 		PF13508
(Acetyltransf_7) 		5 VAL A  93
SER A  86
LEU A  22
ALA A  59
LEU A  71
 None
SO4  A 142 (-3.0A)
None
None
EDO  A 301 ( 4.6A)
 1.17A 3kk6B-2ozhA:
undetectable		 3kk6B-2ozhA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		4 VAL C 359
SER C 257
LEU C 247
LEU C 285
 None
 0.90A 3kk6B-2p9nC:
undetectable		 3kk6B-2p9nC:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvp D-ALANINE-D-ALANINE
LIGASE

(Helicobacter
pylori) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A  24
ILE A  16
ALA A 309
LEU A 312
 None
 0.81A 3kk6B-2pvpA:
undetectable		 3kk6B-2pvpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm8 GTPASE/ATPASE

(Methylobacterium
extorquens) 		PF03308
(ArgK) 		5 VAL A 132
LEU A 194
ILE A  60
ALA A 164
LEU A 129
 None
 1.37A 3kk6B-2qm8A:
undetectable		 3kk6B-2qm8A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsv UNCHARACTERIZED
PROTEIN

(Porphyromonas
gingivalis) 		PF07610
(DUF1573) 		5 VAL A 216
SER A 201
ILE A 203
ALA A 164
LEU A 162
 None
 1.50A 3kk6B-2qsvA:
undetectable		 3kk6B-2qsvA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		5 VAL A 343
SER A 188
ILE A 190
ALA A 128
LEU A 124
 None
 1.34A 3kk6B-2r05A:
undetectable		 3kk6B-2r05A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8b UNCHARACTERIZED
PROTEIN ATU2452

(Agrobacterium
fabrum) 		PF01738
(DLH) 		5 VAL A 189
SER A 211
LEU A 118
ALA A 154
LEU A 169
 None
 1.33A 3kk6B-2r8bA:
undetectable		 3kk6B-2r8bA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 VAL A 306
LEU A 210
ALA A 278
LEU A 170
 None
 0.85A 3kk6B-2rb9A:
undetectable		 3kk6B-2rb9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4n MULTIFUNCTIONAL
PROTEIN SUR E

(Salmonella
enterica) 		PF01975
(SurE) 		5 VAL A 101
SER A 223
LEU A 150
ILE A 171
LEU A 227
 None
 1.34A 3kk6B-2v4nA:
undetectable		 3kk6B-2v4nA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 VAL A 138
LEU A 108
ILE A   4
LEU A  33
 None
 0.90A 3kk6B-2v9iA:
undetectable		 3kk6B-2v9iA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 328
ILE A 287
ALA A 283
LEU A 324
 None
 0.87A 3kk6B-2vd9A:
undetectable		 3kk6B-2vd9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3g TWO COMPONENT SENSOR
HISTIDINE KINASE
DEVS (GAF FAMILY
PROTEIN)

(Mycobacterium
tuberculosis) 		PF13185
(GAF_2) 		4 VAL A 200
LEU A 172
ILE A 121
LEU A  68
 None
 0.76A 3kk6B-2w3gA:
undetectable		 3kk6B-2w3gA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		4 VAL A 312
ILE A 153
ALA A 138
LEU A 316
 None
 0.87A 3kk6B-2ww9A:
undetectable		 3kk6B-2ww9A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA

(Escherichia
coli) 		PF13580
(SIS_2) 		5 VAL A 129
SER A 117
ILE A 171
ALA A 141
LEU A 154
 None
 1.46A 3kk6B-2yvaA:
undetectable		 3kk6B-2yvaA:
17.03