SIMILAR PATTERNS OF AMINO ACIDS FOR 3KIV_A_ACAA100_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b2i PROTEIN
(PLASMINOGEN)

(Homo sapiens) 		PF00051
(Kringle) 		5 ASP A  55
TRP A  62
PHE A  64
ARG A  71
TRP A  72
 AMH  A  84 (-1.7A)
AMH  A  84 (-3.0A)
AMH  A  84 (-4.7A)
AMH  A  84 (-3.6A)
AMH  A  84 (-2.5A)
 1.03A 3kivA-1b2iA:
12.5		 3kivA-1b2iA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i71 APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ARG A  35
ASP A  54
TRP A  60
ARG A  69
 SO4  A 300 (-3.6A)
None
None
SO4  A 300 (-3.8A)
 1.25A 3kivA-1i71A:
17.8		 3kivA-1i71A:
81.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i71 APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ARG A  35
TRP A  60
ARG A  69
TRP A  70
 SO4  A 300 (-3.6A)
None
SO4  A 300 (-3.8A)
None
 0.63A 3kivA-1i71A:
17.8		 3kivA-1i71A:
81.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 ARG A 296
ASP A 294
ASP A 291
TRP A 341
 None
 1.39A 3kivA-1kfwA:
undetectable		 3kivA-1kfwA:
10.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kiv APOLIPOPROTEIN A

(Homo sapiens) 		PF00051
(Kringle) 		6 ASP A  55
ASP A  57
TRP A  62
PHE A  64
ARG A  71
TRP A  72
 None
 0.38A 3kivA-1kivA:
18.3		 3kivA-1kivA:
98.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pkr PLASMINOGEN

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 CL  A  91 ( 4.7A)
None
None
CL  A  90 (-3.6A)
 0.52A 3kivA-1pkrA:
16.1		 3kivA-1pkrA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
TRP A  72
 None
 0.29A 3kivA-1pmlA:
13.4		 3kivA-1pmlA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 279
ASP A 305
ARG A 332
TRP A 334
 None
 1.25A 3kivA-1po0A:
0.0		 3kivA-1po0A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t62 CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF04266
(ASCH) 		4 ASP A1072
ASP A1024
TRP A1026
PHE A1028
 None
 1.33A 3kivA-1t62A:
0.0		 3kivA-1t62A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF00710
(Asparaginase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		4 ARG A 210
ASP A 209
PHE C 135
ARG C 137
 None
 1.45A 3kivA-1zq1A:
undetectable		 3kivA-1zq1A:
10.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2doi ANGIOSTATIN

(Homo sapiens) 		no annotation 4 ASP X 137
ASP X 139
TRP X 144
ARG X 153
 None
 0.29A 3kivA-2doiX:
15.5		 3kivA-2doiX:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2doi ANGIOSTATIN

(Homo sapiens) 		no annotation 4 ASP X 219
TRP X 225
PHE X 227
TRP X 235
 None
 0.65A 3kivA-2doiX:
15.5		 3kivA-2doiX:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2doi ANGIOSTATIN

(Homo sapiens) 		no annotation 4 TRP X 225
PHE X 227
ARG X 234
TRP X 235
 None
 0.57A 3kivA-2doiX:
15.5		 3kivA-2doiX:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 ARG A1049
ASP A1019
PHE A1026
ARG A1029
 None
 1.00A 3kivA-2eyqA:
undetectable		 3kivA-2eyqA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 ARG A 450
ASP A 649
ASP A 646
PHE A 448
 None
 1.36A 3kivA-2h4tA:
undetectable		 3kivA-2h4tA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Homo sapiens) 		PF14580
(LRR_9) 		4 ARG A 132
ASP A 146
ASP A 119
PHE A 136
 None
 1.14A 3kivA-2je1A:
undetectable		 3kivA-2je1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		4 ARG A  67
ASP A 118
PHE A 167
ARG A 283
 None
 1.36A 3kivA-2og7A:
undetectable		 3kivA-2og7A:
13.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pk4 HUMAN PLASMINOGEN
KRINGLE 4

(Homo sapiens) 		PF00051
(Kringle) 		6 ASP A  55
ASP A  57
TRP A  62
PHE A  64
ARG A  71
TRP A  72
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 4.1A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 0.35A 3kivA-2pk4A:
17.5		 3kivA-2pk4A:
85.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASP A 141
ASP A 315
PHE A 214
ARG A 694
 None
 1.45A 3kivA-2vwkA:
undetectable		 3kivA-2vwkA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		4 ASP A 230
ASP A 232
PHE A  13
TRP A  31
 GOL  A1270 (-3.7A)
None
C2F  A3000 (-3.9A)
None
 1.10A 3kivA-2ycjA:
undetectable		 3kivA-2ycjA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zib TYPE II ANTIFREEZE
PROTEIN

(Brachyopsis
segaliensis) 		PF00059
(Lectin_C) 		4 ASP A  98
ASP A 117
ARG A  89
TRP A  91
 None
 1.46A 3kivA-2zibA:
undetectable		 3kivA-2zibA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ARG A  56
ASP A  70
PHE A 225
ARG A 537
 None
 1.49A 3kivA-3cp8A:
undetectable		 3kivA-3cp8A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ARG A 445
ASP A 458
ASP A 457
ARG A 537
 None
 1.21A 3kivA-3cp8A:
undetectable		 3kivA-3cp8A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr7 ADENYLYL-SULFATE
KINASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase) 		4 ARG A  66
ASP A  72
PHE A  75
ARG A  80
 PPS  A2002 (-4.0A)
None
PPS  A2002 (-3.5A)
PPS  A2002 (-3.3A)
 1.50A 3kivA-3cr7A:
undetectable		 3kivA-3cr7A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		4 ASP A 117
ASP A 443
PHE A 278
ARG A 451
 MG  A   1 ( 4.7A)
None
None
None
 1.37A 3kivA-3cuxA:
undetectable		 3kivA-3cuxA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 ASP A 120
ASP A 447
PHE A 281
ARG A 455
 MG  A   1 ( 4.7A)
CSO  A 438 ( 4.8A)
None
None
 1.39A 3kivA-3cv2A:
undetectable		 3kivA-3cv2A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A  33
ASP A 133
ASP A 132
ARG A 126
 None
 1.50A 3kivA-3g1zA:
undetectable		 3kivA-3g1zA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnp OXIDOREDUCTASE

(Bacillus cereus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 182
ASP A 128
ASP A 252
PHE A 237
 None
 1.45A 3kivA-3hnpA:
undetectable		 3kivA-3hnpA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 182
ASP A 128
ASP A 252
PHE A 237
 None
 1.40A 3kivA-3i23A:
undetectable		 3kivA-3i23A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		4 ARG A 227
ASP A 284
PHE A 212
ARG A 225
 None
 1.33A 3kivA-3pmmA:
undetectable		 3kivA-3pmmA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 277
ASP A  93
PHE A 241
ARG A  91
 None
None
None
EFE  A 701 (-4.0A)
 1.35A 3kivA-3qlbA:
undetectable		 3kivA-3qlbA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		4 ARG A 186
ASP A 193
ASP A 219
PHE A 184
 None
 1.42A 3kivA-3qpfA:
undetectable		 3kivA-3qpfA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		4 ARG A 188
ASP A 195
ASP A 221
PHE A 186
 None
 1.49A 3kivA-3qt3A:
undetectable		 3kivA-3qt3A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		4 ASP A 281
ASP A 280
PHE A  56
ARG A 253
 ADE  A 345 (-2.8A)
ZN  A 344 ( 2.5A)
None
None
 1.45A 3kivA-3rysA:
undetectable		 3kivA-3rysA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 ASP A 520
TRP A 526
PHE A 547
ARG A 545
 None
 1.46A 3kivA-3v9fA:
undetectable		 3kivA-3v9fA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 ASP A 594
TRP A 600
PHE A 620
ARG A 618
 None
 0.83A 3kivA-4a2lA:
undetectable		 3kivA-4a2lA:
6.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bvw APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ARG A  35
ASP A  54
TRP A  60
ARG A  69
 CL  A1081 (-3.8A)
HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-3.5A)
 0.78A 3kivA-4bvwA:
18.1		 3kivA-4bvwA:
64.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bvw APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  54
TRP A  60
ARG A  69
TRP A  70
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-3.5A)
HKY  A1080 (-3.5A)
 0.32A 3kivA-4bvwA:
18.1		 3kivA-4bvwA:
64.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgq NON-HEME
CHLOROPEROXIDASE

(Burkholderia
cenocepacia) 		PF00561
(Abhydrolase_1) 		4 ARG A  62
ASP A  36
ASP A  39
TRP A  17
 None
 1.36A 3kivA-4dgqA:
undetectable		 3kivA-4dgqA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 ASP A 137
ASP A 139
TRP A 144
ARG A 153
 None
 0.88A 3kivA-4duuA:
14.4		 3kivA-4duuA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 ASP A 219
TRP A 225
PHE A 227
ARG A 234
TRP A 235
 None
 0.90A 3kivA-4duuA:
14.4		 3kivA-4duuA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 ASP A 413
TRP A 417
PHE A 419
ARG A 426
TRP A 427
 None
 0.65A 3kivA-4duuA:
14.4		 3kivA-4duuA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		4 ARG A 372
ASP A 369
ASP A 365
ARG A 356
 None
 1.46A 3kivA-4ep6A:
undetectable		 3kivA-4ep6A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		4 ARG A 523
ASP A 277
ASP A 274
ARG A 269
 None
 1.44A 3kivA-4ep6A:
undetectable		 3kivA-4ep6A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ARG A 515
ASP A 510
ASP A 508
PHE A 572
 None
 1.49A 3kivA-4lnvA:
undetectable		 3kivA-4lnvA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 129
ASP A 187
PHE A 291
ARG A 290
 None
 1.49A 3kivA-4n54A:
undetectable		 3kivA-4n54A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9d BENZOYLFORMATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ARG A  16
ASP A  13
ASP A   9
PHE A  42
 None
 1.40A 3kivA-4q9dA:
undetectable		 3kivA-4q9dA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 ARG A  30
ASP A  27
ASP A  23
PHE A  49
 None
 1.46A 3kivA-4r6hA:
undetectable		 3kivA-4r6hA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		4 ASP A 215
TRP A 264
PHE A 232
ARG A 270
 None
 1.21A 3kivA-5d8wA:
undetectable		 3kivA-5d8wA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		4 ASP A  80
TRP A  58
PHE A  11
TRP A  17
 None
 1.46A 3kivA-5esrA:
undetectable		 3kivA-5esrA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 ASP A  88
ASP A  90
TRP A  94
TRP A 106
 None
 0.21A 3kivA-5fwsA:
10.3		 3kivA-5fwsA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 ARG A 185
ASP A 484
ASP A 480
PHE A 183
 None
 1.46A 3kivA-5k5tA:
undetectable		 3kivA-5k5tA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mea CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 399
ASP A 369
TRP A 367
PHE A 318
 None
 1.18A 3kivA-5meaA:
undetectable		 3kivA-5meaA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mec CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 399
ASP A 369
TRP A 367
PHE A 318
 None
 1.19A 3kivA-5mecA:
undetectable		 3kivA-5mecA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 ARG A 228
ASP A 149
ASP A 151
PHE A 232
 None
None
MLY  A 250 ( 4.4A)
None
 0.95A 3kivA-5thmA:
undetectable		 3kivA-5thmA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		4 ARG A3123
ASP A2755
ASP A2752
ARG A3088
 None
 1.48A 3kivA-5xauA:
undetectable		 3kivA-5xauA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 4 ARG A  54
ASP A  16
PHE A  89
ARG A  79
 None
 1.10A 3kivA-6f5zA:
undetectable		 3kivA-6f5zA:
23.60