SIMILAR PATTERNS OF AMINO ACIDS FOR 3KHM_A_TPFA501_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0e | XYLOSE ISOMERASE (Thermotoganeapolitana) |
PF01261(AP_endonuc_2) | 4 | PHE A 362ALA A 296ALA A 268THR A 272 | None | 0.96A | 3khmA-1a0eA:undetectable | 3khmA-1a0eA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ej6 | LAMBDA1 (Reovirus sp.) |
no annotation | 4 | ALA B 881ALA B 885THR B 807LEU B 549 | None | 0.94A | 3khmA-1ej6B:undetectable | 3khmA-1ej6B:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ggv | DIENELACTONEHYDROLASE (Pseudomonasputida) |
PF01738(DLH) | 4 | ALA A 216ALA A 220THR A 224LEU A 164 | None | 0.80A | 3khmA-1ggvA:undetectable | 3khmA-1ggvA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hl2 | N-ACETYLNEURAMINATELYASE SUBUNIT (Escherichiacoli) |
PF00701(DHDPS) | 4 | PHE A 100ALA A 78THR A 14LEU A 27 | None | 0.97A | 3khmA-1hl2A:undetectable | 3khmA-1hl2A:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hl2 | N-ACETYLNEURAMINATELYASE SUBUNIT (Escherichiacoli) |
PF00701(DHDPS) | 4 | PHE A 100TYR A 98ALA A 78THR A 14 | None | 0.77A | 3khmA-1hl2A:undetectable | 3khmA-1hl2A:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nio | B-LUFFIN (Luffaaegyptiaca) |
PF00161(RIP) | 4 | TYR A 82TYR A 75ALA A 150ALA A 146 | None | 0.94A | 3khmA-1nioA:undetectable | 3khmA-1nioA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nr6 | CYTOCHROME P450 2C5 (Oryctolaguscuniculus) |
PF00067(p450) | 4 | PHE A 114ALA A 294THR A 298LEU A 359 | DIF A 501 (-4.5A)DIF A 501 ( 3.3A)HEM A 500 ( 3.6A)DIF A 501 (-4.4A) | 0.74A | 3khmA-1nr6A:32.7 | 3khmA-1nr6A:26.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ojg | SENSOR PROTEIN DCUS (Escherichiacoli) |
PF17203(sCache_3_2) | 4 | TYR A 108ALA A 60ALA A 64LEU A 73 | None | 0.92A | 3khmA-1ojgA:undetectable | 3khmA-1ojgA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s4o | GLYCOLIPID2-ALPHA-MANNOSYLTRANSFERASE (Saccharomycescerevisiae) |
PF01793(Glyco_transf_15) | 4 | TYR A 319ALA A 370ALA A 368LEU A 348 | None | 0.95A | 3khmA-1s4oA:undetectable | 3khmA-1s4oA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1soi | MUTT/NUDIX FAMILYPROTEIN (Deinococcusradiodurans) |
PF00293(NUDIX) | 4 | ALA A 62ALA A 66THR A 70LEU A 28 | None | 0.88A | 3khmA-1soiA:undetectable | 3khmA-1soiA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t34 | ATRIAL NATRIURETICPEPTIDE RECEPTOR A (Rattusnorvegicus) |
PF01094(ANF_receptor) | 4 | ALA A 111ALA A 109THR A 106LEU A 104 | None | 0.87A | 3khmA-1t34A:undetectable | 3khmA-1t34A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASEMEDIUM SUBUNIT (Pseudomonasputida) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 4 | ALA C 240ALA C 244THR C 248LEU C 213 | None | 0.50A | 3khmA-1t3qC:undetectable | 3khmA-1t3qC:20.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1x8v | CYTOCHROME P450 51 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | MET A 79PHE A 83ALA A 256THR A 260LEU A 321 | ESL A 471 ( 4.4A)NoneESL A 471 ( 3.4A)HEM A 470 (-3.6A)HEM A 470 (-4.1A) | 0.97A | 3khmA-1x8vA:38.0 | 3khmA-1x8vA:32.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fym | ENOLASE (Escherichiacoli) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | ALA A 22ALA A 34THR A 378LEU A 129 | None | 0.98A | 3khmA-2fymA:undetectable | 3khmA-2fymA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi0 | PUTATIVEPHOSPHOGLYCOLATEPHOSPHATASE (Lactobacillusdelbrueckii) |
PF13419(HAD_2) | 4 | PHE A 96ALA A 24THR A 108LEU A 142 | None | 0.97A | 3khmA-2hi0A:undetectable | 3khmA-2hi0A:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hj0 | PUTATIVE CITRATELYASE, ALFA SUBUNIT (Streptococcusmutans) |
PF04223(CitF) | 4 | TYR A 247ALA A 257ALA A 261THR A 265 | None | 0.88A | 3khmA-2hj0A:undetectable | 3khmA-2hj0A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i80 | D-ALANINE-D-ALANINELIGASE (Staphylococcusaureus) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 4 | MET A 133PHE A 137ALA A 280ALA A 292 | None | 0.97A | 3khmA-2i80A:undetectable | 3khmA-2i80A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iml | HYPOTHETICAL PROTEIN (Archaeoglobusfulgidus) |
PF04289(DUF447) | 4 | ALA A 64ALA A 17THR A 52LEU A 47 | NoneNoneFMN A 200 (-3.7A)FMN A 200 (-4.5A) | 0.88A | 3khmA-2imlA:undetectable | 3khmA-2imlA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m5t | HUMAN RHINOVIRUS 2APROTEINASE (Rhinovirus C) |
PF00947(Pico_P2A) | 4 | ALA A 30ALA A 33THR A 120LEU A 93 | None | 0.88A | 3khmA-2m5tA:undetectable | 3khmA-2m5tA:13.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oqa | LUFFACULIN 1 (Luffaacutangula) |
PF00161(RIP) | 4 | TYR A 81TYR A 74ALA A 149ALA A 145 | None | 0.98A | 3khmA-2oqaA:undetectable | 3khmA-2oqaA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pth | PEPTIDYL-TRNAHYDROLASE (Escherichiacoli) |
PF01195(Pept_tRNA_hydro) | 4 | ALA A 164ALA A 168THR A 172LEU A 89 | None | 0.88A | 3khmA-2pthA:undetectable | 3khmA-2pthA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pzi | PROBABLESERINE/THREONINE-PROTEIN KINASE PKNG (Mycobacteriumtuberculosis) |
PF00069(Pkinase)PF16918(PknG_TPR)PF16919(PknG_rubred) | 4 | ALA A 571ALA A 575THR A 579LEU A 547 | None | 0.85A | 3khmA-2pziA:undetectable | 3khmA-2pziA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlt | (DL)-GLYCEROL-3-PHOSPHATASE 1 (Saccharomycescerevisiae) |
PF13419(HAD_2) | 4 | TYR A 174ALA A 203ALA A 201THR A 221 | NoneNone CA A 278 ( 4.2A)None | 0.98A | 3khmA-2qltA:undetectable | 3khmA-2qltA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvd | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 4 | ALA A 215ALA A 219THR A 223LEU A 24 | None | 0.93A | 3khmA-2uvdA:undetectable | 3khmA-2uvdA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1p | AQUAPORIN PIP2-7 7 (Komagataellapastoris) |
PF00230(MIP) | 4 | PHE A 56ALA A 144ALA A 148THR A 152 | None | 0.57A | 3khmA-2w1pA:undetectable | 3khmA-2w1pA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whn | PILUS ASSEMBLYPROTEIN PILC (Thermusthermophilus) |
PF00482(T2SSF) | 4 | TYR A 131ALA A 68THR A 95LEU A 104 | None | 0.99A | 3khmA-2whnA:undetectable | 3khmA-2whnA:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ymv | ACG NITROREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 4 | ALA A 19ALA A 15THR A 11LEU A 7 | None | 0.95A | 3khmA-2ymvA:undetectable | 3khmA-2ymvA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3amj | ZINC PEPTIDASEINACTIVE SUBUNIT (Sphingomonassp. A1) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 4 | TYR B 36ALA B 223ALA B 227THR B 231 | None | 0.75A | 3khmA-3amjB:undetectable | 3khmA-3amjB:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3god | CAS1 (Pseudomonasaeruginosa) |
PF01867(Cas_Cas1) | 4 | ALA A 233ALA A 237THR A 241LEU A 313 | None | 0.69A | 3khmA-3godA:undetectable | 3khmA-3godA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjw | 50S RIBOSOMALPROTEIN L7AE (Pyrococcusfuriosus) |
PF01248(Ribosomal_L7Ae) | 4 | TYR C 80ALA C 98THR C 37LEU C 67 | None U D 30 ( 3.5A) U D 30 ( 3.6A)None | 0.94A | 3khmA-3hjwC:undetectable | 3khmA-3hjwC:13.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd5 | 28S RIBOSOMALPROTEIN S2,MITOCHONDRIAL28S RIBOSOMALPROTEIN S9,MITOCHONDRIAL (Bos taurus) |
PF00318(Ribosomal_S2)PF00380(Ribosomal_S9) | 4 | TYR I 152PHE B 160ALA B 197ALA B 201 | None | 0.72A | 3khmA-3jd5I:undetectable | 3khmA-3jd5I:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kf3 | INVERTASE (Schwanniomycesoccidentalis) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | MET A 48ALA A 311ALA A 309LEU A 54 | None | 0.95A | 3khmA-3kf3A:undetectable | 3khmA-3kf3A:20.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 5 | MET A 106PHE A 110ALA A 287ALA A 291THR A 295 | VNF A 490 ( 3.8A)NoneVNF A 490 ( 3.9A)VNF A 490 ( 4.0A)VNF A 490 ( 4.0A) | 0.61A | 3khmA-3kswA:45.6 | 3khmA-3kswA:98.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 5 | MET A 106PHE A 110TYR A 116ALA A 287ALA A 291 | VNF A 490 ( 3.8A)NoneVNF A 490 (-4.6A)VNF A 490 ( 3.9A)VNF A 490 ( 4.0A) | 0.66A | 3khmA-3kswA:45.6 | 3khmA-3kswA:98.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 5 | TYR A 103MET A 106ALA A 287ALA A 291THR A 295 | NoneVNF A 490 ( 3.8A)VNF A 490 ( 3.9A)VNF A 490 ( 4.0A)VNF A 490 ( 4.0A) | 0.59A | 3khmA-3kswA:45.6 | 3khmA-3kswA:98.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 5 | TYR A 103MET A 106TYR A 116ALA A 287ALA A 291 | NoneVNF A 490 ( 3.8A)VNF A 490 (-4.6A)VNF A 490 ( 3.9A)VNF A 490 ( 4.0A) | 0.77A | 3khmA-3kswA:45.6 | 3khmA-3kswA:98.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 4 | MET A 105PHE A 109TYR A 102ALA A 290 | TPF A 490 ( 4.0A)TPF A 490 (-4.5A)HEM A 481 (-4.7A)TPF A 490 ( 3.4A) | 0.97A | 3khmA-3l4dA:55.4 | 3khmA-3l4dA:76.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 7 | TYR A 102MET A 105PHE A 109ALA A 286ALA A 290THR A 294LEU A 355 | HEM A 481 (-4.7A)TPF A 490 ( 4.0A)TPF A 490 (-4.5A)TPF A 490 (-3.4A)TPF A 490 ( 3.4A)TPF A 490 ( 3.5A)TPF A 490 (-4.4A) | 0.56A | 3khmA-3l4dA:55.4 | 3khmA-3l4dA:76.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 7 | TYR A 102MET A 105TYR A 115ALA A 286ALA A 290THR A 294LEU A 355 | HEM A 481 (-4.7A)TPF A 490 ( 4.0A)HEM A 481 ( 4.9A)TPF A 490 (-3.4A)TPF A 490 ( 3.4A)TPF A 490 ( 3.5A)TPF A 490 (-4.4A) | 0.49A | 3khmA-3l4dA:55.4 | 3khmA-3l4dA:76.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l76 | ASPARTOKINASE (Synechocystissp. PCC 6803) |
PF00696(AA_kinase)PF01842(ACT)PF13840(ACT_7) | 4 | ALA A 165ALA A 161THR A 157LEU A 150 | None | 0.95A | 3khmA-3l76A:undetectable | 3khmA-3l76A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p5m | ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteriumavium) |
PF00378(ECH_1) | 4 | ALA A 107ALA A 109THR A 85LEU A 210 | None | 0.92A | 3khmA-3p5mA:undetectable | 3khmA-3p5mA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p5m | ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteriumavium) |
PF00378(ECH_1) | 4 | ALA A 107ALA A 109THR A 85LEU A 213 | None | 0.94A | 3khmA-3p5mA:undetectable | 3khmA-3p5mA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q2i | DEHYDROGENASE (Chromobacteriumviolaceum) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | ALA A 49ALA A 53THR A 57LEU A 39 | NAI A 500 ( 3.9A)NoneNoneNone | 0.90A | 3khmA-3q2iA:undetectable | 3khmA-3q2iA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q2k | OXIDOREDUCTASE (Bordetellapertussis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | ALA A 48ALA A 52THR A 56LEU A 38 | NAI A 500 ( 3.9A)NoneNoneNone | 0.89A | 3khmA-3q2kA:undetectable | 3khmA-3q2kA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r44 | FATTY ACYL COASYNTHETASE FADD13(FATTY-ACYL-COASYNTHETASE) (Mycobacteriumtuberculosis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | PHE A 231ALA A 253THR A 485LEU A 286 | None | 0.95A | 3khmA-3r44A:undetectable | 3khmA-3r44A:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rkr | SHORT CHAINOXIDOREDUCTASE (unculturedbacterium Bio5) |
PF00106(adh_short) | 4 | ALA A 213ALA A 217THR A 221LEU A 4 | None | 0.70A | 3khmA-3rkrA:undetectable | 3khmA-3rkrA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uon | HUMAN M2 MUSCARINICACETYLCHOLINE,RECEPTOR T4 LYSOZYMEFUSION PROTEIN (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 4 | TYR A 440ALA A 391ALA A 395THR A 399 | None | 0.92A | 3khmA-3uonA:2.2 | 3khmA-3uonA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4co8 | ETS TRANSLOCATIONVARIANT 4 (Homo sapiens) |
PF00178(Ets) | 4 | TYR A 418MET A 408PHE A 420LEU A 395 | None | 0.73A | 3khmA-4co8A:undetectable | 3khmA-4co8A:15.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g3j | STEROL14-ALPHA-DEMETHYLASE (Trypanosomabrucei) |
PF00067(p450) | 7 | MET A 106PHE A 110TYR A 116ALA A 287ALA A 291THR A 295LEU A 356 | VNT A 502 ( 3.9A)VNT A 502 (-4.4A)HEM A 501 ( 4.5A)VNT A 502 ( 3.9A)HEM A 501 ( 3.5A)VNT A 502 ( 3.2A)VNT A 502 ( 4.5A) | 0.57A | 3khmA-4g3jA:55.7 | 3khmA-4g3jA:85.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g3j | STEROL14-ALPHA-DEMETHYLASE (Trypanosomabrucei) |
PF00067(p450) | 4 | PHE A 110TYR A 103ALA A 287ALA A 291 | VNT A 502 (-4.4A)VNT A 502 ( 4.8A)VNT A 502 ( 3.9A)HEM A 501 ( 3.5A) | 0.68A | 3khmA-4g3jA:55.7 | 3khmA-4g3jA:85.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g3j | STEROL14-ALPHA-DEMETHYLASE (Trypanosomabrucei) |
PF00067(p450) | 4 | TYR A 103ALA A 288THR A 295LEU A 356 | VNT A 502 ( 4.8A)HEM A 501 (-4.4A)VNT A 502 ( 3.2A)VNT A 502 ( 4.5A) | 0.99A | 3khmA-4g3jA:55.7 | 3khmA-4g3jA:85.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g3j | STEROL14-ALPHA-DEMETHYLASE (Trypanosomabrucei) |
PF00067(p450) | 4 | TYR A 103MET A 106THR A 295LEU A 356 | VNT A 502 ( 4.8A)VNT A 502 ( 3.9A)VNT A 502 ( 3.2A)VNT A 502 ( 4.5A) | 0.93A | 3khmA-4g3jA:55.7 | 3khmA-4g3jA:85.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnl | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Enterococcusgallinarum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 181ALA A 215ALA A 219THR A 251LEU A 227 | None | 1.34A | 3khmA-4hnlA:undetectable | 3khmA-4hnlA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hz4 | GLUTATHIONE-S-TRANSFERASE (Actinobacilluspleuropneumoniae) |
PF00043(GST_C)PF02798(GST_N) | 4 | ALA A 193ALA A 197THR A 201LEU A 30 | None | 0.67A | 3khmA-4hz4A:undetectable | 3khmA-4hz4A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ihc | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Dickeyaparadisiaca) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 199ALA A 233ALA A 237THR A 269LEU A 245 | None | 1.47A | 3khmA-4ihcA:undetectable | 3khmA-4ihcA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iri | TRANSCRIPTIONALREGULATOR ERG (Homo sapiens) |
PF00178(Ets) | 4 | TYR A 371MET A 361PHE A 373LEU A 348 | None | 0.77A | 3khmA-4iriA:undetectable | 3khmA-4iriA:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9u | TRK SYSTEM POTASSIUMUPTAKE PROTEIN TRKH (Vibrioparahaemolyticus) |
PF02386(TrkH) | 4 | ALA A 306ALA A 310THR A 314LEU A 339 | None | 0.79A | 3khmA-4j9uA:undetectable | 3khmA-4j9uA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jso | OLIGOPEPTIDE ABCTRANSPORTER,PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN (Thermotogamaritima) |
PF00496(SBP_bac_5) | 4 | TYR A 298ALA A 504ALA A 305LEU A 313 | None | 0.87A | 3khmA-4jsoA:undetectable | 3khmA-4jsoA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l0c | DEFORMYLASE (Pseudomonasputida) |
PF12697(Abhydrolase_6) | 4 | MET A 1PHE A 18ALA A 42LEU A 166 | None | 0.76A | 3khmA-4l0cA:undetectable | 3khmA-4l0cA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l15 | FIDGETIN-LIKEPROTEIN 1 (Caenorhabditiselegans) |
PF00004(AAA)PF09336(Vps4_C) | 4 | MET A 307PHE A 378ALA A 404THR A 290 | None | 0.86A | 3khmA-4l15A:undetectable | 3khmA-4l15A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mt1 | DRUG EFFLUX PROTEIN (Neisseriagonorrhoeae) |
PF00873(ACR_tran) | 4 | PHE A 626ALA A 639ALA A 643THR A 647 | None | 0.82A | 3khmA-4mt1A:undetectable | 3khmA-4mt1A:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n4p | ACYLNEURAMINATELYASE (Mycoplasmasynoviae) |
PF00701(DHDPS) | 4 | TYR A 244TYR A 241THR A 51LEU A 257 | NoneNone CL A 300 (-4.0A)None | 0.80A | 3khmA-4n4pA:undetectable | 3khmA-4n4pA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nq1 | 4-HYDROXY-TETRAHYDRODIPICOLINATESYNTHASE (Legionellapneumophila) |
PF00701(DHDPS) | 4 | ALA A 74ALA A 41THR A 11LEU A 23 | None | 0.97A | 3khmA-4nq1A:undetectable | 3khmA-4nq1A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nq1 | 4-HYDROXY-TETRAHYDRODIPICOLINATESYNTHASE (Legionellapneumophila) |
PF00701(DHDPS) | 4 | TYR A 94ALA A 74ALA A 41THR A 11 | None | 0.93A | 3khmA-4nq1A:undetectable | 3khmA-4nq1A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4omg | GERANYLGERANYLDIPHOSPHATE CYCLASE (Streptomycesmelanosporofaciens) |
no annotation | 4 | TYR A 194ALA A 208THR A 212LEU A 281 | None | 0.96A | 3khmA-4omgA:undetectable | 3khmA-4omgA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u14 | MUSCARINICACETYLCHOLINERECEPTORM3,ENDOLYSIN,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Escherichiavirus T4;Rattusnorvegicus) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 4 | TYR A 543ALA A 494ALA A 498THR A 502 | None | 0.93A | 3khmA-4u14A:undetectable | 3khmA-4u14A:22.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uhi | STEROL 14-ALPHADEMETHYLASE (Homo sapiens) |
PF00067(p450) | 5 | TYR A 131PHE A 139TYR A 145ALA A 311THR A 315 | VFV A 580 (-4.1A)VFV A 580 (-4.2A)HEM A 540 (-4.5A)HEM A 540 ( 3.4A)HEM A 540 (-3.6A) | 0.64A | 3khmA-4uhiA:37.9 | 3khmA-4uhiA:35.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uym | 14-ALPHA STEROLDEMETHYLASE (Aspergillusfumigatus) |
PF00067(p450) | 5 | TYR A 122PHE A 130TYR A 136ALA A 303ALA A 307 | VOR A 590 (-3.8A)VOR A 590 (-4.6A)HEM A 580 (-4.6A)VOR A 590 ( 4.4A)VOR A 590 ( 4.0A) | 0.65A | 3khmA-4uymA:41.4 | 3khmA-4uymA:31.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wlh | KYNURENINE--OXOGLUTARATE TRANSAMINASE 1 (Homo sapiens) |
PF00155(Aminotran_1_2) | 4 | MET A 131TYR A 128ALA A 107ALA A 103 | None | 0.80A | 3khmA-4wlhA:undetectable | 3khmA-4wlhA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wp0 | KYNURENINE--OXOGLUTARATE TRANSAMINASE 1 (Homo sapiens) |
PF00155(Aminotran_1_2) | 4 | MET A 131TYR A 128ALA A 107ALA A 103 | None | 0.81A | 3khmA-4wp0A:undetectable | 3khmA-4wp0A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwl | EXOGLUCANASE S (Clostridiumcellulovorans) |
PF02011(Glyco_hydro_48) | 4 | TYR A 55ALA A 234ALA A 63THR A 66 | None | 0.99A | 3khmA-4xwlA:undetectable | 3khmA-4xwlA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yrp | HISTIDYL-TRNASYNTHETASE (Trypanosomacruzi) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 5 | TYR A 149MET A 173PHE A 360ALA A 191ALA A 194 | None | 1.50A | 3khmA-4yrpA:undetectable | 3khmA-4yrpA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a08 | PROBABLEMANNOSYLTRANSFERASEKTR4 (Saccharomycescerevisiae) |
PF01793(Glyco_transf_15) | 4 | TYR A 342ALA A 393ALA A 391LEU A 371 | None | 0.99A | 3khmA-5a08A:undetectable | 3khmA-5a08A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5apm | VP1VP3 (Parechovirus A) |
no annotation | 4 | PHE A 206ALA A 108THR A 216LEU B 130 | None | 0.96A | 3khmA-5apmA:undetectable | 3khmA-5apmA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5axh | DEXTRANASE (Thermoanaerobacterpseudethanolicus) |
PF13199(Glyco_hydro_66) | 4 | TYR A 235TYR A 184THR A 276LEU A 279 | GLC A 703 ( 4.7A)GLC A 703 ( 4.4A)NoneNone | 0.98A | 3khmA-5axhA:undetectable | 3khmA-5axhA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b5z | PTLCIB4 H88A MUTANT (Phaeodactylumtricornutum) |
no annotation | 4 | PHE A 74ALA A 72ALA A 129LEU A 186 | None | 0.90A | 3khmA-5b5zA:undetectable | 3khmA-5b5zA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5brl | STAR-RELATED LIPIDTRANSFER PROTEIN 4 (Mus musculus) |
PF01852(START) | 4 | ALA A 201ALA A 205THR A 209LEU A 98 | None | 0.92A | 3khmA-5brlA:undetectable | 3khmA-5brlA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c0u | ALKYLMERCURY LYASE (Escherichiacoli) |
PF03243(MerB)PF12324(HTH_15) | 4 | PHE A 165ALA A 171ALA A 175LEU A 181 | None | 0.82A | 3khmA-5c0uA:undetectable | 3khmA-5c0uA:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5djq | CBB3-TYPE CYTOCHROMEC OXIDASE SUBUNITCCON1CBB3-TYPE CYTOCHROMEC OXIDASE SUBUNITCCOP1 (Pseudomonasstutzeri) |
PF00115(COX1)PF13442(Cytochrome_CBB3)PF14715(FixP_N) | 4 | MET C 1ALA C 10THR C 13LEU A 271 | None | 0.77A | 3khmA-5djqC:undetectable | 3khmA-5djqC:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8g | FRIEND LEUKEMIAINTEGRATION 1TRANSCRIPTION FACTOR (Homo sapiens) |
PF00178(Ets) | 4 | TYR A 358MET A 348PHE A 360LEU A 335 | None | 0.67A | 3khmA-5e8gA:undetectable | 3khmA-5e8gA:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f2o | FATTY ACIDO-METHYLTRANSFERASE (Mycobacteriummarinum) |
PF03492(Methyltransf_7) | 4 | PHE A 222TYR A 224ALA A 258ALA A 154 | None5UF A 401 ( 4.3A)None5UF A 401 ( 4.9A) | 0.87A | 3khmA-5f2oA:undetectable | 3khmA-5f2oA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fcl | CRISPR-ASSOCIATEDENDONUCLEASE CAS1 (Pectobacteriumatrosepticum) |
PF01867(Cas_Cas1) | 4 | ALA A 234ALA A 238THR A 242LEU A 314 | None | 0.77A | 3khmA-5fclA:undetectable | 3khmA-5fclA:21.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fsa | CYP51 VARIANT1 (Candidaalbicans) |
PF00067(p450) | 4 | PHE A 126TYR A 132THR A 311LEU A 376 | X2N A 590 (-4.8A)HEM A 580 (-4.1A)HEM A 580 (-3.6A)X2N A 590 (-4.3A) | 0.88A | 3khmA-5fsaA:35.7 | 3khmA-5fsaA:32.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsh | CSM6 (Thermusthermophilus) |
PF09670(Cas_Cas02710) | 4 | ALA A 63ALA A 65THR A 95LEU A 99 | None | 0.99A | 3khmA-5fshA:undetectable | 3khmA-5fshA:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gmx | CARBOXYLESTERASE (unculturedbacterium) |
PF00144(Beta-lactamase) | 4 | TYR A 92ALA A 169ALA A 173THR A 177 | None | 0.95A | 3khmA-5gmxA:undetectable | 3khmA-5gmxA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs1 | LANOSTEROL 14-ALPHADEMETHYLASE (Saccharomycescerevisiae) |
PF00067(p450) | 4 | PHE A 134TYR A 140THR A 318LEU A 380 | VOR A 602 (-4.7A)HEM A 601 (-4.3A)HEM A 601 (-3.4A)VOR A 602 (-4.0A) | 0.51A | 3khmA-5hs1A:39.3 | 3khmA-5hs1A:29.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs1 | LANOSTEROL 14-ALPHADEMETHYLASE (Saccharomycescerevisiae) |
PF00067(p450) | 4 | TYR A 126TYR A 140THR A 318LEU A 380 | VOR A 602 ( 3.8A)HEM A 601 (-4.3A)HEM A 601 (-3.4A)VOR A 602 (-4.0A) | 0.66A | 3khmA-5hs1A:39.3 | 3khmA-5hs1A:29.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i39 | L-AMINO ACIDDEAMINASE (Proteusvulgaris) |
PF01266(DAO) | 4 | PHE A 201ALA A 100THR A 436LEU A 65 | NoneNoneFAD A 501 (-3.9A)FAD A 501 (-3.8A) | 0.91A | 3khmA-5i39A:undetectable | 3khmA-5i39A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ilu | ETS TRANSLOCATIONVARIANT 4 (Homo sapiens) |
PF00178(Ets) | 4 | TYR A 418MET A 408PHE A 420LEU A 395 | None | 0.73A | 3khmA-5iluA:undetectable | 3khmA-5iluA:11.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5inw | C-TERMINAL PEPTIDEOF PUTATIVEANGIOTENSINOGENPUTATIVEANGIOTENSINOGEN (Lampetrafluviatilis) |
PF00079(Serpin) | 4 | ALA A 83ALA A 81THR C 439LEU A 160 | None | 1.00A | 3khmA-5inwA:undetectable | 3khmA-5inwA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jlc | LANOSTEROL 14-ALPHADEMETHYLASE ([Candida]glabrata) |
PF00067(p450) | 5 | TYR A 127PHE A 135TYR A 141THR A 319LEU A 381 | 1YN A 602 ( 3.8A)1YN A 602 ( 4.6A)HEM A 601 (-4.2A)HEM A 601 ( 3.5A)1YN A 602 ( 4.7A) | 0.68A | 3khmA-5jlcA:38.6 | 3khmA-5jlcA:29.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvt | FRIEND LEUKEMIAINTEGRATION 1TRANSCRIPTION FACTOR (Homo sapiens) |
PF00178(Ets) | 4 | TYR A 358MET A 348PHE A 360LEU A 335 | None | 0.79A | 3khmA-5jvtA:undetectable | 3khmA-5jvtA:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k3h | ACYL-COENZYME AOXIDASE (Caenorhabditiselegans) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 4 | ALA A 353ALA A 357THR A 361LEU A 386 | None | 0.70A | 3khmA-5k3hA:undetectable | 3khmA-5k3hA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kei | 2,3-DIHYDROXYBENZOATE-AMP LIGASE (Mycolicibacteriumsmegmatis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | TYR A 249ALA A 290ALA A 287LEU A 301 | None | 0.87A | 3khmA-5keiA:undetectable | 3khmA-5keiA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lp4 | PENICILLIN-BINDINGPROTEIN 2 (PBP2) (Helicobacterpylori) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 4 | PHE A 302ALA A 267ALA A 159LEU A 275 | None | 0.96A | 3khmA-5lp4A:undetectable | 3khmA-5lp4A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nii | THIOREDOXINREDUCTASE (Desulfovibriovulgaris) |
no annotation | 4 | ALA A 14ALA A 18THR A 22LEU A 6 | FAD A 401 (-3.3A)NoneNoneNone | 0.90A | 3khmA-5niiA:undetectable | 3khmA-5niiA:9.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb7 | BETA-GALACTOSIDASE (Bifidobacteriumanimalis) |
no annotation | 4 | ALA A 404ALA A 452THR A 477LEU A 481 | None | 0.94A | 3khmA-5xb7A:undetectable | 3khmA-5xb7A:22.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6ay4 | CYP51, STEROL14ALPHA-DEMETHYLASE (Naegleriafowleri) |
no annotation | 8 | TYR A 107MET A 110PHE A 114TYR A 120ALA A 289ALA A 293THR A 297LEU A 358 | TPF A 506 (-4.2A)TPF A 506 (-4.6A)TPF A 506 (-4.4A)NoneTPF A 506 (-3.5A)TPF A 506 ( 3.2A)HEM A 501 (-3.4A)TPF A 506 ( 4.4A) | 0.79A | 3khmA-6ay4A:45.0 | 3khmA-6ay4A:37.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d47 | BETA SLIDING CLAMP (Mycobacteriummarinum) |
no annotation | 4 | MET A 299PHE A 301ALA A 275LEU A 344 | None | 0.99A | 3khmA-6d47A:undetectable | 3khmA-6d47A:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g3u | - (-) |
no annotation | 4 | TYR A 9ALA A 609THR A 637LEU A 663 | None | 0.89A | 3khmA-6g3uA:undetectable | 3khmA-6g3uA:undetectable |