SIMILAR PATTERNS OF AMINO ACIDS FOR 3KEE_B_30BB500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		5 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 1.04A 3keeB-1a8qA:
undetectable		 3keeB-1a8qA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		10 GLN A  41
HIS A  57
GLY A  58
ASP A  81
VAL A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.61A 3keeB-1cu1A:
32.3		 3keeB-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 HIS A  57
GLY A  58
ASP A  81
VAL A 132
LYS A 136
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.64A 3keeB-1cu1A:
32.3		 3keeB-1cu1A:
32.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.12A 3keeB-1efpA:
undetectable		 3keeB-1efpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.08A 3keeB-1efvA:
undetectable		 3keeB-1efvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 HIS A 460
ASP A 514
LYS A 614
GLY A 615
SER A 617
 SO4  A2001 ( 3.9A)
None
SO4  A2001 (-2.9A)
SO4  A2001 (-4.1A)
SO4  A2001 ( 2.7A)
 0.89A 3keeB-1elvA:
12.0		 3keeB-1elvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep5 CAPSID PROTEIN C

(Venezuelan
equine
encephalitis
virus) 		no annotation 5 HIS B 152
ASP B 174
LYS B 223
GLY B 224
SER B 226
 None
 1.01A 3keeB-1ep5B:
12.2		 3keeB-1ep5B:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 HIS A 282
ASP A 252
GLY A  82
SER A 155
ALA A 285
 EPE  A 455 (-4.0A)
None
EPE  A 455 (-3.5A)
EPE  A 455 (-1.4A)
None
 1.08A 3keeB-1evqA:
undetectable		 3keeB-1evqA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 HIS A 282
ASP A 252
VAL A  96
GLY A  82
SER A 155
 EPE  A 455 (-4.0A)
None
None
EPE  A 455 (-3.5A)
EPE  A 455 (-1.4A)
 1.05A 3keeB-1evqA:
undetectable		 3keeB-1evqA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		6 HIS A 353
ASP A 324
VAL A 150
GLY A  66
SER A 153
ALA A 178
 None
 1.45A 3keeB-1hlgA:
undetectable		 3keeB-1hlgA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1r VIRAL IL-6

(Human
gammaherpesvirus
8) 		PF00489
(IL6) 		5 GLY B 133
VAL B 145
GLY B 140
PHE B  87
ALA B 149
 None
 1.02A 3keeB-1i1rB:
undetectable		 3keeB-1i1rB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 HIS A 338
ASP A 308
VAL A 138
GLY A 126
SER A 202
 None
 1.01A 3keeB-1jkmA:
undetectable		 3keeB-1jkmA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 GLN H  61
HIS H  57
ASP H 102
GLY H 193
SER H 195
 None
 0.82A 3keeB-1kigH:
10.8		 3keeB-1kigH:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kuu CONSERVED PROTEIN

(Methanothermobacter) 		PF07826
(IMP_cyclohyd) 		5 GLY A 119
GLY A  10
SER A  16
ALA A 188
ALA A 187
 None
 1.01A 3keeB-1kuuA:
undetectable		 3keeB-1kuuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1

(Escherichia
coli) 		PF00923
(TAL_FSA) 		5 GLN A 138
VAL A 146
PHE A 167
ALA A 165
ALA A 164
 None
None
None
GOL  A 250 ( 2.9A)
None
 1.04A 3keeB-1l6wA:
undetectable		 3keeB-1l6wA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLY A 362
ASP A 449
VAL A 410
ALA A 433
ALA A 434
 None
 0.99A 3keeB-1lamA:
undetectable		 3keeB-1lamA:
19.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 GLN A  41
HIS A  57
GLY A  58
ASP A  81
VAL A 132
PHE A 154
ALA A 156
ALA A 157
 None
 0.82A 3keeB-1ns3A:
32.7		 3keeB-1ns3A:
96.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 HIS A  57
GLY A  58
ASP A  81
GLY A 137
ARG A 155
 None
 0.93A 3keeB-1ns3A:
32.7		 3keeB-1ns3A:
96.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 HIS A  57
GLY A  58
ASP A  81
VAL A 132
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.59A 3keeB-1ns3A:
32.7		 3keeB-1ns3A:
96.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		5 HIS A  47
ASP A  97
GLY A 169
SER A 171
ALA A 188
 None
 0.73A 3keeB-1p3cA:
11.9		 3keeB-1p3cA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  76
GLY A 104
SER A  93
ALA A  95
ALA A 109
 None
 1.00A 3keeB-1p9hA:
undetectable		 3keeB-1p9hA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		6 GLY A  90
VAL A 128
GLY A 118
SER A 107
ALA A 109
ALA A 123
 None
 1.26A 3keeB-1p9hA:
undetectable		 3keeB-1p9hA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5r PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		5 GLY H  -1
VAL H 195
GLY H  16
ALA H  43
ALA H  42
 None
 1.11A 3keeB-1q5rH:
undetectable		 3keeB-1q5rH:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		5 HIS G  57
ASP G 102
LYS G 192
GLY G 193
SER G 195
 None
 0.84A 3keeB-1sgfG:
11.6		 3keeB-1sgfG:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY B 390
VAL B 342
GLY B 164
ALA B 397
ALA B 398
 None
 1.04A 3keeB-1tqyB:
undetectable		 3keeB-1tqyB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 GLY A  68
VAL A 153
SER A 141
PHE A 144
ALA A 170
 None
 1.05A 3keeB-1wd5A:
undetectable		 3keeB-1wd5A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu0 ATP SYNTHASE C CHAIN

(Bacillus sp.
PS3) 		PF00137
(ATP-synt_C) 		5 GLY A  62
GLY A  15
ARG A  72
ALA A   9
ALA A   8
 None
 1.02A 3keeB-1wu0A:
undetectable		 3keeB-1wu0A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 HIS A 141
GLY A 140
VAL A  97
GLY A 119
ALA A  93
 MPD  A3003 (-3.9A)
None
None
None
MPD  A3003 ( 4.4A)
 1.04A 3keeB-1wz8A:
undetectable		 3keeB-1wz8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.81A 3keeB-1y8tA:
14.4		 3keeB-1y8tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		5 GLY A  31
VAL A  51
GLY A  28
SER A  35
ALA A  42
 None
 1.10A 3keeB-2e18A:
undetectable		 3keeB-2e18A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		5 GLY A 225
GLY A 267
PHE A 295
ALA A 273
ALA A 274
 PLP  A 400 (-3.5A)
None
None
None
None
 1.02A 3keeB-2isqA:
undetectable		 3keeB-2isqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		5 GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
 None
ADP  A 700 (-3.4A)
None
None
None
 0.88A 3keeB-2qz4A:
undetectable		 3keeB-2qz4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		5 GLN A 214
VAL A 292
GLY A 217
ARG A 179
ALA A 178
 GAX  A 352 (-4.2A)
GAX  A 352 ( 4.5A)
None
None
GAX  A 352 ( 4.9A)
 1.09A 3keeB-2rhqA:
undetectable		 3keeB-2rhqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B 414
GLY B  42
SER B  29
PHE B  30
ALA B  21
 None
 0.99A 3keeB-2vduB:
undetectable		 3keeB-2vduB:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 HIS A  39
ASP A  77
GLY A 155
SER A 157
ALA A 174
 None
 0.73A 3keeB-2vidA:
13.4		 3keeB-2vidA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 VAL A 225
GLY A 222
ARG A 111
ALA A 108
ALA A 105
 None
 1.10A 3keeB-2w8qA:
undetectable		 3keeB-2w8qA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.11A 3keeB-2wgeA:
undetectable		 3keeB-2wgeA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqh IMMUNOGLOBULIN-BINDI
NG PROTEIN EIBD

(Escherichia
coli) 		PF05658
(YadA_head) 		5 GLY A 166
GLY A 194
SER A 183
ALA A 185
ALA A 199
 None
 1.11A 3keeB-2xqhA:
undetectable		 3keeB-2xqhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xua 3-OXOADIPATE
ENOL-LACTONASE

(Paraburkholderia
xenovorans) 		PF12146
(Hydrolase_4) 		6 ASP A 217
VAL A 107
GLY A 102
SER A 100
ALA A 126
ALA A 127
 None
 1.48A 3keeB-2xuaA:
undetectable		 3keeB-2xuaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 GLY A   7
VAL A 248
GLY A 331
ALA A 190
ALA A 244
 None
 1.09A 3keeB-2yrrA:
undetectable		 3keeB-2yrrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		5 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 1.06A 3keeB-3ajaA:
undetectable		 3keeB-3ajaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.74A 3keeB-3ak5A:
7.2		 3keeB-3ak5A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch7 6-PHOSPHOGLUCONOLACT
ONASE

(Leishmania
braziliensis) 		PF01182
(Glucosamine_iso) 		5 GLY A  46
VAL A 228
GLY A 164
ALA A 220
ALA A 261
 None
 1.12A 3keeB-3ch7A:
undetectable		 3keeB-3ch7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 5 ASP A 213
VAL A  56
GLY A  59
SER A 145
ALA A 169
 None
None
SO4  A 306 (-3.2A)
SO4  A 304 ( 2.7A)
None
 0.99A 3keeB-3d0kA:
undetectable		 3keeB-3d0kA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 153
ASP A  93
VAL A 610
GLY A 146
ALA A  35
 None
 1.10A 3keeB-3fhhA:
undetectable		 3keeB-3fhhA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
 None
 1.04A 3keeB-3gcwA:
undetectable		 3keeB-3gcwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 0.94A 3keeB-3gcwA:
undetectable		 3keeB-3gcwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h90 FERROUS-IRON EFFLUX
PUMP FIEF

(Escherichia
coli) 		PF01545
(Cation_efflux)
PF16916
(ZT_dimer) 		5 GLN A 143
VAL A  60
GLY A 240
ALA A  83
ALA A  82
 None
 1.01A 3keeB-3h90A:
undetectable		 3keeB-3h90A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.07A 3keeB-3heaA:
undetectable		 3keeB-3heaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 5 VAL A 228
GLY A 269
ARG A 244
ALA A 200
ALA A 201
 None
None
SO4  A   2 (-2.8A)
None
None
 1.09A 3keeB-3n6zA:
undetectable		 3keeB-3n6zA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A 173
ASP A 203
GLY A 280
SER A 282
ALA A 299
 None
 0.76A 3keeB-3qo6A:
14.9		 3keeB-3qo6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rit DIPEPTIDE EPIMERASE

(Methylococcus
capsulatus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 104
VAL A 344
GLY A 349
ALA A 304
ALA A 303
 None
 1.05A 3keeB-3ritA:
undetectable		 3keeB-3ritA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.94A 3keeB-3s29A:
undetectable		 3keeB-3s29A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  36
GLY A  64
SER A  53
ALA A  55
ALA A  69
 None
 1.06A 3keeB-3s6lA:
undetectable		 3keeB-3s6lA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  50
GLY A  78
SER A  67
ALA A  69
ALA A  83
 None
 1.04A 3keeB-3s6lA:
undetectable		 3keeB-3s6lA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		6 GLY A  92
VAL A 131
GLY A 120
SER A 109
ALA A 111
ALA A 125
 None
 1.19A 3keeB-3s6lA:
undetectable		 3keeB-3s6lA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.66A 3keeB-3stjA:
14.2		 3keeB-3stjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 GLY A 324
VAL A 283
GLY A 328
ALA A 228
ALA A 279
 None
 1.10A 3keeB-3ti7A:
undetectable		 3keeB-3ti7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		5 GLY A  18
VAL A 422
SER A 336
ALA A 332
ALA A 331
 None
 0.95A 3keeB-3ue9A:
undetectable		 3keeB-3ue9A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.81A 3keeB-3ufaA:
13.0		 3keeB-3ufaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00106
(adh_short) 		5 GLY A  81
ASP A  84
VAL A  49
ALA A  30
ALA A  26
 None
 1.09A 3keeB-3wtcA:
undetectable		 3keeB-3wtcA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A  12
VAL A  88
ARG A  71
ALA A  68
ALA A  65
 None
 1.11A 3keeB-4dfeA:
undetectable		 3keeB-4dfeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2

(Pleurotus
eryngii) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 GLY A  51
GLY A  63
SER A  64
PHE A  68
ALA A 131
 CA  A 402 ( 4.7A)
None
CA  A 402 (-2.4A)
None
None
 1.10A 3keeB-4fcsA:
undetectable		 3keeB-4fcsA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		5 GLY A 395
ASP A 404
VAL A 465
GLY A 425
PHE A 421
 NA  A 514 (-4.3A)
NA  A 514 (-2.8A)
None
None
None
 1.02A 3keeB-4fe9A:
undetectable		 3keeB-4fe9A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 GLN A  31
GLY A  82
VAL A  57
ALA A 109
ALA A 104
 None
 1.06A 3keeB-4fn7A:
undetectable		 3keeB-4fn7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 VAL A 328
GLY A 441
ARG A 251
ALA A 196
ALA A 201
 None
None
None
AMP  A 601 (-4.2A)
None
 1.09A 3keeB-4ga6A:
undetectable		 3keeB-4ga6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 GLY A 331
VAL A  59
GLY A 111
ALA A  63
ALA A  61
 None
 1.11A 3keeB-4hxyA:
undetectable		 3keeB-4hxyA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A  38
GLY A 272
SER A 752
ALA A 239
ALA A 236
 None
 1.04A 3keeB-4iigA:
undetectable		 3keeB-4iigA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inl SERINE PROTEASE SPLD

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 HIS A  39
ASP A  78
GLY A 154
SER A 156
ALA A 173
 None
 0.73A 3keeB-4inlA:
13.4		 3keeB-4inlA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo sapiens) 		PF00328
(His_Phos_2) 		5 GLN A 131
GLY A 128
SER A 172
ARG A 168
ALA A 333
 None
None
None
MLA  A 501 (-3.7A)
None
 1.09A 3keeB-4jocA:
undetectable		 3keeB-4jocA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 266
HIS A 290
GLY A 268
GLY A 250
ALA A 281
 FAD  A 401 (-4.1A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.3A)
None
None
 1.11A 3keeB-4kpuA:
undetectable		 3keeB-4kpuA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		5 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.77A 3keeB-4mzdA:
undetectable		 3keeB-4mzdA:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		11 GLN A  41
HIS A  57
GLY A  58
ASP A  81
LYS A 136
GLY A 137
SER A 139
PHE A 154
ARG A 155
ALA A 156
ALA A 157
 2R8  A 301 ( 3.5A)
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
2R8  A 301 (-3.6A)
GOL  A 310 ( 2.6A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-2.6A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.6A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
 0.39A 3keeB-4nwkA:
30.5		 3keeB-4nwkA:
75.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 GLN B 382
HIS B 226
ASP B 186
GLY B 384
ALA B 290
 None
 0.99A 3keeB-4ov6B:
undetectable		 3keeB-4ov6B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
 None
 0.93A 3keeB-4ov6B:
undetectable		 3keeB-4ov6B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		5 GLY A 191
VAL A 111
GLY A 152
ALA A 155
ALA A 136
 None
None
289  A 408 (-4.4A)
None
None
 1.10A 3keeB-4q1qA:
undetectable		 3keeB-4q1qA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		5 GLY A 304
VAL A 225
GLY A 265
ALA A 268
ALA A 249
 289  A 435 ( 4.8A)
None
289  A 415 ( 3.7A)
None
None
 1.11A 3keeB-4q1qA:
undetectable		 3keeB-4q1qA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A  30
VAL A 230
GLY A  33
ALA A 217
ALA A 218
 None
 1.10A 3keeB-4r8eA:
undetectable		 3keeB-4r8eA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 273
GLY A 274
ASP A 404
GLY A 288
ALA A 426
 None
 0.91A 3keeB-4rbnA:
undetectable		 3keeB-4rbnA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzp ENGINEERED PROTEIN
OR366

(synthetic
construct) 		PF00514
(Arm)
PF13646
(HEAT_2) 		6 GLY A  32
VAL A  82
GLY A  74
SER A  73
ALA A  69
ALA A 109
 None
 1.46A 3keeB-4rzpA:
undetectable		 3keeB-4rzpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x27 FUSOLIN

(Entomopoxvirinae) 		PF03067
(LPMO_10) 		5 HIS A   1
GLY A   2
VAL A 221
GLY A 224
PHE A 105
 CU  A 401 (-3.1A)
None
None
None
None
 1.04A 3keeB-4x27A:
undetectable		 3keeB-4x27A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.57A 3keeB-4x2xA:
11.8		 3keeB-4x2xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn1 FUSOLIN

(Anomala cuprea
entomopoxvirus) 		PF03067
(LPMO_10) 		5 HIS A   1
GLY A   2
VAL A 221
GLY A 224
PHE A 105
 None
 1.04A 3keeB-4yn1A:
undetectable		 3keeB-4yn1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn2 FUSOLIN

(unidentified
entomopoxvirus) 		PF03067
(LPMO_10) 		5 HIS A   1
GLY A   2
VAL A 218
GLY A 221
PHE A 103
 ZN  A 404 (-3.0A)
None
None
None
None
 1.03A 3keeB-4yn2A:
undetectable		 3keeB-4yn2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 HIS B 364
ASP C 116
VAL B 381
GLY B 370
ALA B 328
 None
 1.08A 3keeB-5a8rB:
undetectable		 3keeB-5a8rB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
 None
 1.03A 3keeB-5cykA:
undetectable		 3keeB-5cykA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 GLN A 369
VAL A 376
GLY A 371
ALA A 330
ALA A 329
 None
 1.08A 3keeB-5ee0A:
undetectable		 3keeB-5ee0A:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		9 GLN A1041
HIS A1057
GLY A1058
ASP A1081
GLY A1137
PHE A1154
ARG A1155
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.37A 3keeB-5eqqA:
30.8		 3keeB-5eqqA:
80.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		5 GLY A 574
VAL A 568
GLY A 571
SER A 555
ALA A 522
 None
None
None
L6I  A1615 (-2.7A)
None
 1.12A 3keeB-5fnuA:
undetectable		 3keeB-5fnuA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLN A 682
GLY A 681
ASP A 328
ALA A 677
ALA A 676
 None
 1.08A 3keeB-5ju6A:
undetectable		 3keeB-5ju6A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.95A 3keeB-5kp7A:
undetectable		 3keeB-5kp7A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 HIS A 317
ASP A 287
GLY A 117
SER A 190
ALA A 320
 None
 1.11A 3keeB-5mifA:
undetectable		 3keeB-5mifA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA
METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT GAMMA

(Methanothermococcus
thermolithotrophicus) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 HIS B 364
ASP C 116
VAL B 381
GLY B 370
ALA B 328
 None
 1.09A 3keeB-5n1qB:
undetectable		 3keeB-5n1qB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 HIS B 365
ASP C 116
VAL B 382
GLY B 371
ALA B 329
 None
 1.11A 3keeB-5n28B:
undetectable		 3keeB-5n28B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 5 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.05A 3keeB-5no5A:
undetectable		 3keeB-5no5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.76A 3keeB-5to3B:
10.5		 3keeB-5to3B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
 None
 0.95A 3keeB-5vlhA:
undetectable		 3keeB-5vlhA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 0.87A 3keeB-5vlhA:
undetectable		 3keeB-5vlhA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 7 GLN A  41
HIS A  57
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.66A 3keeB-5wdxA:
25.3		 3keeB-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 8 HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.33A 3keeB-5wdxA:
25.3		 3keeB-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ap2 MONOCLONAL ANTIBODY
C219

(Mus musculus) 		PF07686
(V-set) 		3 PHE A  77
TYR A  98
LEU A  53
 None
 0.70A 3keeB-1ap2A:
undetectable		 3keeB-1ap2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		3 PHE A  86
TYR A 143
LEU A  70
 None
 0.71A 3keeB-1c4oA:
0.0		 3keeB-1c4oA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 PHE A 381
TYR A 320
LEU A 432
 None
 0.80A 3keeB-1clwA:
0.0		 3keeB-1clwA:
16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		3 PHE A  43
TYR A  56
LEU A 135
 None
 0.38A 3keeB-1cu1A:
32.3		 3keeB-1cu1A:
32.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6l ANTI-FERRITIN
IMMUNOGLOBULIN LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 PHE L  71
TYR L  92
LEU L  47
 None
 0.67A 3keeB-1f6lL:
undetectable		 3keeB-1f6lL:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		3 PHE A 143
TYR A 158
LEU A 106
 None
 0.62A 3keeB-1i60A:
0.0		 3keeB-1i60A:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 PHE A  43
TYR A  56
LEU A 135
 None
 0.45A 3keeB-1ns3A:
32.7		 3keeB-1ns3A:
96.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 PHE A1316
TYR A1332
LEU A1284
 None
 0.70A 3keeB-1ofeA:
undetectable		 3keeB-1ofeA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qac IMMUNOGLOBULIN LIGHT
CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		3 PHE A  71
TYR A  92
LEU A  47
 None
 0.75A 3keeB-1qacA:
undetectable		 3keeB-1qacA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r75 HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF09149
(DUF1935) 		3 PHE A  47
TYR A  27
LEU A 102
 None
 0.66A 3keeB-1r75A:
undetectable		 3keeB-1r75A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1viw ALPHA-AMYLASE-INHIBI
TOR

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		3 PHE B 105
TYR B 186
LEU B  82
 None
 0.61A 3keeB-1viwB:
undetectable		 3keeB-1viwB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 PHE A 598
TYR A 515
LEU A 529
 None
 0.56A 3keeB-1xdpA:
undetectable		 3keeB-1xdpA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		3 PHE A1146
TYR A1112
LEU A1119
 None
 0.77A 3keeB-1xv5A:
undetectable		 3keeB-1xv5A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq6 MINOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF08949
(DUF1860) 		3 PHE A 318
TYR A 279
LEU A 274
 None
 0.78A 3keeB-1yq6A:
undetectable		 3keeB-1yq6A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2f EXOCYST COMPLEX
COMPONENT SEC15

(Drosophila
melanogaster) 		PF04091
(Sec15) 		3 PHE X 288
TYR X 227
LEU X 280
 None
 0.68A 3keeB-2a2fX:
undetectable		 3keeB-2a2fX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 PHE A 374
TYR A 402
LEU A 353
 None
 0.80A 3keeB-2csdA:
undetectable		 3keeB-2csdA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuh TENASCIN-X

(Homo sapiens) 		PF00041
(fn3) 		3 PHE A  23
TYR A  61
LEU A  96
 None
 0.72A 3keeB-2cuhA:
undetectable		 3keeB-2cuhA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		3 PHE A 347
TYR A 284
LEU A 354
 None
 0.79A 3keeB-2cw7A:
undetectable		 3keeB-2cw7A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 PHE A 107
TYR A 119
LEU A 104
 None
 0.72A 3keeB-2fgeA:
undetectable		 3keeB-2fgeA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4

(Homo sapiens) 		PF04099
(Sybindin) 		3 PHE D 119
TYR D 147
LEU D 111
 None
 0.49A 3keeB-2j3tD:
undetectable		 3keeB-2j3tD:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j63 AP-ENDONUCLEASE

(Leishmania
major) 		PF03372
(Exo_endo_phos) 		3 PHE A 440
TYR A 392
LEU A 165
 None
 0.71A 3keeB-2j63A:
undetectable		 3keeB-2j63A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		3 PHE A 156
TYR A  68
LEU A  55
 None
 0.77A 3keeB-2oq2A:
undetectable		 3keeB-2oq2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056

(Geobacillus
kaustophilus) 		PF08282
(Hydrolase_3) 		3 PHE A 205
TYR A 249
LEU A  15
 None
 0.80A 3keeB-2pq0A:
undetectable		 3keeB-2pq0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		3 PHE A 403
TYR A 396
LEU A 252
 None
 0.73A 3keeB-2q8nA:
undetectable		 3keeB-2q8nA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 PHE D 829
TYR D 820
LEU D 834
 None
None
A  B  -4 ( 4.4A)
 0.72A 3keeB-2vnuD:
undetectable		 3keeB-2vnuD:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 PHE J 829
TYR J 820
LEU J 834
 None
 0.75A 3keeB-2wp8J:
undetectable		 3keeB-2wp8J:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		3 PHE A 147
TYR A  36
LEU A 119
 None
 0.72A 3keeB-2x2uA:
undetectable		 3keeB-2x2uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 PHE A 416
TYR A 535
LEU A 331
 None
 0.56A 3keeB-2ycbA:
undetectable		 3keeB-2ycbA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auv SC-DSFV DERIVED FROM
THE G6-FAB

(Homo sapiens) 		PF07686
(V-set) 		3 PHE A  82
TYR A 103
LEU A  58
 None
 0.72A 3keeB-3auvA:
undetectable		 3keeB-3auvA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bd3 CATALYTIC ANTIBODY

(Mus musculus) 		PF07686
(V-set) 		3 PHE A 235
TYR A 256
LEU A 211
 None
 0.74A 3keeB-3bd3A:
undetectable		 3keeB-3bd3A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		3 PHE A 136
TYR A 235
LEU A 146
 None
 0.61A 3keeB-3djcA:
undetectable		 3keeB-3djcA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dur ANTIBODY FV FRAGMENT
SAG173-04

(Mus musculus) 		PF07686
(V-set) 		3 PHE A  71
TYR A  92
LEU A  47
 None
KDO  A 303 (-4.9A)
None
 0.72A 3keeB-3durA:
undetectable		 3keeB-3durA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		3 PHE A  65
TYR A  73
LEU A   7
 None
None
CL  A 159 (-4.4A)
 0.77A 3keeB-3exnA:
undetectable		 3keeB-3exnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		3 PHE A 190
TYR A 206
LEU A 269
 None
 0.78A 3keeB-3h9pA:
undetectable		 3keeB-3h9pA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy0 FAB 14, LIGHT DOMAIN

(Mus musculus) 		PF07686
(V-set) 		3 PHE L  71
TYR L  92
LEU L  47
 None
 0.75A 3keeB-3iy0L:
undetectable		 3keeB-3iy0L:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		3 PHE A 430
TYR A 456
LEU A 449
 None
 0.76A 3keeB-3j4jA:
undetectable		 3keeB-3j4jA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7e H16.V5 FAB LIGHT
CHAIN

(Mus musculus) 		no annotation 3 PHE L  77
TYR L  98
LEU L  53
 None
 0.79A 3keeB-3j7eL:
undetectable		 3keeB-3j7eL:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF05076
(SUFU) 		3 PHE A 116
TYR A  53
LEU A 120
 None
 0.78A 3keeB-3k5jA:
undetectable		 3keeB-3k5jA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 PHE A 671
TYR A 349
LEU A 299
 None
 0.69A 3keeB-3la4A:
undetectable		 3keeB-3la4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp9 LS-24

(Lathyrus
sativus) 		PF00045
(Hemopexin) 		3 PHE A  82
TYR A  62
LEU A  85
 None
 0.80A 3keeB-3lp9A:
undetectable		 3keeB-3lp9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE A  71
TYR A  92
LEU A  47
 None
 0.68A 3keeB-3mnzA:
undetectable		 3keeB-3mnzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE L  71
TYR L  92
LEU L  47
 None
 0.70A 3keeB-3ntcL:
undetectable		 3keeB-3ntcL:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o52 GDP-MANNOSE
PYROPHOSPHATASE NUDK

(Escherichia
coli) 		PF00293
(NUDIX) 		3 PHE A 160
TYR A 183
LEU A 156
 None
NA  A7113 (-3.9A)
None
 0.76A 3keeB-3o52A:
undetectable		 3keeB-3o52A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc7 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		3 PHE A 120
TYR A 167
LEU A 153
 None
 0.63A 3keeB-3oc7A:
undetectable		 3keeB-3oc7A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120) 		PF00561
(Abhydrolase_1) 		3 PHE A 271
TYR A  34
LEU A 237
 None
 0.73A 3keeB-3qyjA:
undetectable		 3keeB-3qyjA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 PHE A 286
TYR A 267
LEU A  81
 None
 0.69A 3keeB-3rl3A:
undetectable		 3keeB-3rl3A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 16F6 - HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE H  35
TYR H  59
LEU H  20
 None
 0.79A 3keeB-3s88H:
undetectable		 3keeB-3s88H:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td7 FAD-LINKED
SULFHYDRYL OXIDASE
R596

(Acanthamoeba
polyphaga
mimivirus) 		PF04777
(Evr1_Alr) 		3 PHE A 165
TYR A 172
LEU A 160
 None
 0.78A 3keeB-3td7A:
undetectable		 3keeB-3td7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Sphingomonas
sp. SKA58) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE A  18
TYR A 383
LEU A  21
 None
 0.80A 3keeB-3thuA:
undetectable		 3keeB-3thuA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgo EFEM M75 PEPTIDASE

(Pseudomonas
syringae) 		PF09375
(Peptidase_M75) 		3 PHE A 164
TYR A  51
LEU A  39
 None
 0.79A 3keeB-4bgoA:
undetectable		 3keeB-4bgoA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4big UNCHARACTERIZED
LIPOPROTEIN
SAOUHSC_00053

(Staphylococcus
aureus) 		PF04507
(DUF576) 		3 PHE A 232
TYR A 186
LEU A 235
 None
 0.74A 3keeB-4bigA:
undetectable		 3keeB-4bigA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		3 PHE A  42
TYR A  39
LEU A  45
 C2E  A 501 (-3.6A)
None
None
 0.70A 3keeB-4f48A:
undetectable		 3keeB-4f48A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		3 PHE A 114
TYR A  51
LEU A 209
 None
 0.75A 3keeB-4gpgA:
9.8		 3keeB-4gpgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 11
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF10156
(Med17)
no annotation 		3 PHE Q 397
TYR K  95
LEU Q 473
 None
 0.75A 3keeB-4h63Q:
undetectable		 3keeB-4h63Q:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
LIGHT CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE L  71
TYR L  92
LEU L  47
 None
 0.70A 3keeB-4hbcL:
undetectable		 3keeB-4hbcL:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE L  71
TYR L  92
LEU L  47
 None
 0.80A 3keeB-4hjjL:
undetectable		 3keeB-4hjjL:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjz TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		3 PHE A 430
TYR A 456
LEU A 449
 None
 0.75A 3keeB-4kjzA:
undetectable		 3keeB-4kjzA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0k DRAIII

(Deinococcus
radiophilus) 		no annotation 3 PHE A 196
TYR A 127
LEU A 162
 None
 0.70A 3keeB-4l0kA:
undetectable		 3keeB-4l0kA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR

(Parabacteroides
distasonis) 		PF04773
(FecR)
PF16344
(DUF4974) 		3 PHE A 175
TYR A 156
LEU A 197
 None
 0.73A 3keeB-4m0hA:
undetectable		 3keeB-4m0hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 PHE A 435
TYR A 341
LEU A 415
 None
 0.68A 3keeB-4mmhA:
undetectable		 3keeB-4mmhA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msx PRE-MRNA-SPLICING
FACTOR SAD1

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		3 PHE A  88
TYR A  31
LEU A  94
 None
 0.71A 3keeB-4msxA:
undetectable		 3keeB-4msxA:
16.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 PHE A  43
TYR A  56
LEU A 135
 2R8  A 301 (-4.6A)
None
2R8  A 301 (-4.4A)
 0.38A 3keeB-4nwkA:
30.5		 3keeB-4nwkA:
75.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus) 		PF00822
(PMP22_Claudin) 		3 PHE A  45
TYR A  50
LEU A 158
 None
OLC  A 201 (-4.3A)
None
 0.73A 3keeB-4p79A:
undetectable		 3keeB-4p79A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		3 PHE A 147
TYR A  36
LEU A 119
 None
 0.73A 3keeB-4ux8A:
undetectable		 3keeB-4ux8A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4y HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN

(Homo sapiens) 		PF07686
(V-set) 		3 PHE B  71
TYR B  92
LEU B  47
 None
 0.63A 3keeB-4x4yB:
undetectable		 3keeB-4x4yB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		3 PHE A  29
TYR A  46
LEU A  36
 None
 0.75A 3keeB-4y9sA:
undetectable		 3keeB-4y9sA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn2 FUSOLIN

(unidentified
entomopoxvirus) 		PF03067
(LPMO_10) 		3 PHE A 136
TYR A 223
LEU A 132
 None
 0.78A 3keeB-4yn2A:
undetectable		 3keeB-4yn2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0n FAB CA33 LIGHT CHAIN

(Oryctolagus
cuniculus) 		no annotation 3 PHE L  71
TYR L  92
LEU L  47
 None
 0.73A 3keeB-5c0nL:
undetectable		 3keeB-5c0nL:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		3 PHE A 541
TYR A 472
LEU A 517
 None
 0.79A 3keeB-5dgkA:
undetectable		 3keeB-5dgkA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drz HIV ANTIBODY F240
LIGHT CHAIN

(Homo sapiens) 		no annotation 3 PHE L  71
TYR L  92
LEU L  47
 None
 0.71A 3keeB-5drzL:
undetectable		 3keeB-5drzL:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e59 FRNE PROTEIN

(Deinococcus
radiodurans) 		PF01323
(DSBA) 		3 PHE A 110
TYR A 178
LEU A  54
 None
 0.73A 3keeB-5e59A:
undetectable		 3keeB-5e59A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 PHE A1043
TYR A1056
LEU A1135
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
 0.26A 3keeB-5eqqA:
30.8		 3keeB-5eqqA:
80.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f72 SINGLE CHAIN FV FROM
A FAB

(Homo sapiens) 		no annotation 3 PHE T 212
TYR T 233
LEU T 188
 None
 0.75A 3keeB-5f72T:
undetectable		 3keeB-5f72T:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		3 PHE A 584
TYR A 587
LEU A 540
 None
 0.76A 3keeB-5gvbA:
undetectable		 3keeB-5gvbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gx8 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Streptobacillus
moniliformis) 		PF13416
(SBP_bac_8) 		3 PHE A 404
TYR A 148
LEU A 401
 None
 0.66A 3keeB-5gx8A:
undetectable		 3keeB-5gx8A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 PHE A 210
TYR A 195
LEU A 389
 None
 0.69A 3keeB-5imyA:
undetectable		 3keeB-5imyA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 3 PHE A 252
TYR A 206
LEU A  15
 AKG  A 301 (-4.8A)
None
None
 0.76A 3keeB-5j4rA:
undetectable		 3keeB-5j4rA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE

(Thermotoga
maritima) 		PF01553
(Acyltransferase) 		3 PHE A  13
TYR A  20
LEU A   8
 None
DD9  A 304 ( 4.7A)
None
 0.71A 3keeB-5kymA:
undetectable		 3keeB-5kymA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113

(Listeria
monocytogenes) 		PF06778
(Chlor_dismutase) 		3 PHE A  17
TYR A  61
LEU A  99
 None
 0.72A 3keeB-5loqA:
undetectable		 3keeB-5loqA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1q PHAGE TERMINASE
LARGE SUBUNIT

(Thermus phage
G20c) 		PF17289
(Terminase_6C) 		3 PHE A 304
TYR A 301
LEU A 307
 None
 0.76A 3keeB-5m1qA:
undetectable		 3keeB-5m1qA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 3 PHE A  55
TYR A  88
LEU A  36
 GOL  A 403 (-3.4A)
None
None
 0.69A 3keeB-5m86A:
undetectable		 3keeB-5m86A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mps PRE-MRNA-PROCESSING
FACTOR 17

(Saccharomyces
cerevisiae) 		PF00249
(Myb_DNA-binding) 		3 PHE o 302
TYR o 350
LEU o 299
 None
C  I  59 ( 4.7A)
None
 0.63A 3keeB-5mpso:
undetectable		 3keeB-5mpso:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		3 PHE 1 249
TYR 1 646
LEU 1 692
 None
 0.77A 3keeB-5mz61:
undetectable		 3keeB-5mz61:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbi DESIGN OF ANTIBODIES

(Escherichia
coli) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE L  75
TYR L  96
LEU L  51
 None
 0.79A 3keeB-5nbiL:
undetectable		 3keeB-5nbiL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 3 PHE A 584
TYR A 587
LEU A 540
 None
 0.75A 3keeB-5ogsA:
undetectable		 3keeB-5ogsA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		3 PHE A  17
TYR A  61
LEU A  99
 None
 0.68A 3keeB-5t2kA:
undetectable		 3keeB-5t2kA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 3 PHE D 592
TYR D 589
LEU D 573
 None
 0.69A 3keeB-5t4yD:
undetectable		 3keeB-5t4yD:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 PHE A  73
TYR A  96
LEU A  76
 None
 0.71A 3keeB-5thhA:
undetectable		 3keeB-5thhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		3 PHE A1025
TYR A1110
LEU A1017
 None
 0.78A 3keeB-5ue8A:
undetectable		 3keeB-5ue8A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 3 PHE A  43
TYR A  56
LEU A 135
 None
 0.28A 3keeB-5wdxA:
25.3		 3keeB-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 PHE A 550
TYR A 557
LEU A 570
 None
 0.78A 3keeB-5xgjA:
undetectable		 3keeB-5xgjA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		3 PHE A 400
TYR A 406
LEU A 392
 None
 0.78A 3keeB-5xhqA:
undetectable		 3keeB-5xhqA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs2 CYCLIN-C

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		3 PHE B 195
TYR B 192
LEU B 160
 None
 0.74A 3keeB-5xs2B:
undetectable		 3keeB-5xs2B:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 PHE C1978
TYR C2030
LEU C1934
 None
 0.66A 3keeB-5y3rC:
undetectable		 3keeB-5y3rC:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhi PROTEIN YIIM

(Escherichia
coli) 		no annotation 3 PHE A  84
TYR A  67
LEU A  88
 None
 0.73A 3keeB-5yhiA:
undetectable		 3keeB-5yhiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 3 PHE A 545
TYR A 552
LEU A 736
 None
 0.77A 3keeB-6c6lA:
undetectable		 3keeB-6c6lA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5

(Homo sapiens) 		no annotation 3 PHE D 278
TYR D 191
LEU D 270
 None
 0.76A 3keeB-6cetD:
undetectable		 3keeB-6cetD:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqc SCFV OF 9C12
ANTIBODY

(Mus musculus) 		no annotation 3 PHE D  78
TYR D  99
LEU D  54
 None
 0.78A 3keeB-6eqcD:
undetectable		 3keeB-6eqcD:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTD

(Rhodothermus
marinus) 		no annotation 3 PHE D 110
TYR D 101
LEU D 113
 None
HEC  A 301 (-4.3A)
None
 0.67A 3keeB-6f0kD:
undetectable		 3keeB-6f0kD:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 3 PHE B 678
TYR B 975
LEU A 856
 None
 0.72A 3keeB-6f42B:
undetectable		 3keeB-6f42B:
19.64