SIMILAR PATTERNS OF AMINO ACIDS FOR 3KEC_B_HAEB271

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		3 HIS A 144
GLU A 145
HIS A 148
 ZN  A 350 (-3.3A)
ZN  A 350 ( 4.6A)
ZN  A 350 (-3.3A)
 0.19A 3kecB-1bqbA:
3.2		 3kecB-1bqbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsz PROTEIN (PEPTIDE
DEFORMYLASE)

(Escherichia
coli) 		PF01327
(Pep_deformylase) 		3 HIS A 132
GLU A 133
HIS A 136
 FE  A2001 (-3.3A)
FE  A2001 (-4.2A)
FE  A2001 ( 3.3A)
 0.21A 3kecB-1bszA:
undetectable		 3kecB-1bszA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		3 HIS A 142
GLU A 143
HIS A 146
 ZN  A 800 (-3.2A)
ZN  A 800 ( 4.7A)
ZN  A 800 (-3.3A)
 0.16A 3kecB-1budA:
10.6		 3kecB-1budA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 HIS A 229
GLU A 230
HIS A 233
 ZN  A 500 (-3.2A)
ZN  A 500 ( 4.2A)
ZN  A 500 (-3.3A)
 0.14A 3kecB-1f82A:
undetectable		 3kecB-1f82A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 HIS P 169
GLU P 170
HIS P 173
 ZN  P 600 (-3.4A)
ZN  P 600 ( 4.0A)
ZN  P 600 (-3.4A)
 0.18A 3kecB-1h71P:
13.0		 3kecB-1h71P:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfs STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 201
GLU A 202
HIS A 205
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
 0.22A 3kecB-1hfsA:
28.9		 3kecB-1hfsA:
61.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		3 HIS A 219
GLU A 220
HIS A 223
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
 0.20A 3kecB-1hv5A:
22.9		 3kecB-1hv5A:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		3 HIS A 144
GLU A 145
HIS A 148
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
 0.19A 3kecB-1kugA:
10.6		 3kecB-1kugA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 401
GLU A 402
HIS A 405
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
 0.14A 3kecB-1l6jA:
24.0		 3kecB-1l6jA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqw PEPTIDE DEFORMYLASE
PDF1

(Staphylococcus
aureus) 		PF01327
(Pep_deformylase) 		3 HIS A 154
GLU A 155
HIS A 158
 ZN  A 202 (-3.7A)
None
ZN  A 202 (-3.7A)
 0.18A 3kecB-1lqwA:
undetectable		 3kecB-1lqwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lry PEPTIDE DEFORMYLASE

(Pseudomonas
aeruginosa) 		PF01327
(Pep_deformylase) 		3 HIS A 133
GLU A 134
HIS A 137
 ZN  A 168 ( 3.4A)
BB2  A 170 (-2.6A)
ZN  A 168 ( 3.5A)
 0.19A 3kecB-1lryA:
undetectable		 3kecB-1lryA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		3 HIS A 142
GLU A 143
HIS A 146
 ZN  A 400 (-3.2A)
ZN  A 400 ( 4.4A)
ZN  A 400 (-3.3A)
 0.12A 3kecB-1nd1A:
10.7		 3kecB-1nd1A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		3 HIS A 142
GLU A 143
HIS A 146
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
 0.12A 3kecB-1quaA:
10.7		 3kecB-1quaA:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 246
GLU A 247
HIS A 250
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
 0.21A 3kecB-1rm8A:
26.8		 3kecB-1rm8A:
48.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 201
GLU A 202
HIS A 205
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
 0.11A 3kecB-1slmA:
28.4		 3kecB-1slmA:
43.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		3 HIS A 142
GLU A 143
HIS A 146
 ZN  A 999 (-3.5A)
ZN  A 999 ( 4.2A)
ZN  A 999 (-3.5A)
 0.12A 3kecB-1wniA:
10.7		 3kecB-1wniA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		3 HIS 1 469
GLU 1 470
HIS 1 473
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
 0.16A 3kecB-1y791:
4.6		 3kecB-1y791:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 HIS A 211
GLU A 212
HIS A 215
 ZN  A 422 ( 3.3A)
SO4  A 500 (-2.4A)
ZN  A 422 ( 3.3A)
 0.15A 3kecB-1zl6A:
2.0		 3kecB-1zl6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aie PEPTIDE DEFORMYLASE

(Streptococcus
pneumoniae) 		PF01327
(Pep_deformylase) 		3 HIS P 173
GLU P 174
HIS P 177
 NI  P 502 ( 3.4A)
SB9  P 501 (-2.7A)
NI  P 502 ( 3.3A)
 0.18A 3kecB-2aieP:
undetectable		 3kecB-2aieP:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 335
GLU A 336
HIS A 339
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
 0.12A 3kecB-2erqA:
9.5		 3kecB-2erqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew7 PEPTIDE DEFORMYLASE

(Helicobacter
pylori) 		PF01327
(Pep_deformylase) 		3 HIS A 138
GLU A 139
HIS A 142
 CO  A 300 (-3.3A)
CO  A 300 ( 4.0A)
CO  A 300 (-3.3A)
 0.19A 3kecB-2ew7A:
undetectable		 3kecB-2ew7A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 HIS A 229
GLU A 230
HIS A 233
 ZN  A 500 (-3.1A)
ZN  A 500 ( 4.2A)
ZN  A 500 (-3.3A)
 0.17A 3kecB-2fpqA:
undetectable		 3kecB-2fpqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		3 HIS A 356
GLU A 357
HIS A 360
 ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
ZN  A 601 (-3.3A)
 0.17A 3kecB-2h1nA:
2.3		 3kecB-2h1nA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 HIS A 229
GLU A 230
HIS A 233
 ZN  A1291 (-3.5A)
ZN  A1291 ( 4.6A)
ZN  A1291 (-3.4A)
 0.20A 3kecB-2np0A:
undetectable		 3kecB-2np0A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 HIS A 223
GLU A 224
HIS A 227
 ZN  A   1 (-3.3A)
ZN  A   1 ( 4.2A)
ZN  A   1 (-3.3A)
 0.18A 3kecB-2nz9A:
undetectable		 3kecB-2nz9A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		3 HIS A 473
GLU A 474
HIS A 477
 ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
 0.19A 3kecB-2o36A:
3.5		 3kecB-2o36A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os3 PEPTIDE DEFORMYLASE

(Streptococcus
pyogenes) 		PF01327
(Pep_deformylase) 		3 HIS A 174
GLU A 175
HIS A 178
 CO  A 300 ( 3.6A)
BB2  A 400 (-2.8A)
CO  A 300 ( 3.4A)
 0.22A 3kecB-2os3A:
undetectable		 3kecB-2os3A:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 197
GLU A 198
HIS A 201
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
 0.14A 3kecB-2oy4A:
28.5		 3kecB-2oy4A:
60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 HIS A 229
GLU A 230
HIS A 233
 ZN  A 431 (-3.3A)
ZN  A 431 ( 4.0A)
ZN  A 431 (-3.3A)
 0.16A 3kecB-2qn0A:
undetectable		 3kecB-2qn0A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 410
GLU A 411
HIS A 414
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
 0.17A 3kecB-2rjqA:
10.0		 3kecB-2rjqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		3 HIS A 122
GLU A 123
HIS A 127
 None
 0.21A 3kecB-2v28A:
undetectable		 3kecB-2v28A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7m ARCHAEMETZINCIN

(Methanopyrus
kandleri) 		PF07998
(Peptidase_M54) 		3 HIS A 125
GLU A 126
HIS A 129
 ZN  A1174 (-3.2A)
ZN  A1174 ( 4.2A)
ZN  A1174 (-3.2A)
 0.16A 3kecB-2x7mA:
7.2		 3kecB-2x7mA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 HIS A 383
GLU A 384
HIS A 387
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
 0.10A 3kecB-2xy9A:
3.2		 3kecB-2xy9A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 HIS A 361
GLU A 362
HIS A 365
 3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
 0.12A 3kecB-2xydA:
3.5		 3kecB-2xydA:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 219
GLU A 220
HIS A 223
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
 0.14A 3kecB-2y6cA:
24.8		 3kecB-2y6cA:
52.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 HIS A 353
GLU A 354
HIS A 357
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
 0.17A 3kecB-2yd0A:
4.8		 3kecB-2yd0A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 3 HIS A 356
GLU A 357
HIS A 360
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
 0.22A 3kecB-3ahmA:
2.0		 3kecB-3ahmA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 410
GLU A 411
HIS A 414
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
 0.13A 3kecB-3b8zA:
10.3		 3kecB-3b8zA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		3 HIS A 400
GLU A 401
HIS A 404
 ZN  A 703 (-3.3A)
ZN  A 703 ( 4.7A)
ZN  A 703 (-3.4A)
 0.12A 3kecB-3ce2A:
undetectable		 3kecB-3ce2A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dse BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 HIS A 223
GLU A 224
HIS A 227
 ZN  A 501 (-3.2A)
ZN  A 501 ( 4.4A)
ZN  A 501 (-3.3A)
 0.16A 3kecB-3dseA:
undetectable		 3kecB-3dseA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 HIS A 607
GLU A 608
HIS A 611
 ZN  A 771 ( 3.4A)
RDF  A 817 (-2.4A)
ZN  A 771 ( 3.3A)
 0.20A 3kecB-3dwbA:
4.2		 3kecB-3dwbA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edi TOLLOID-LIKE PROTEIN
1

(Homo sapiens) 		PF01400
(Astacin) 		3 HIS A  92
GLU A  93
HIS A  96
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
 0.11A 3kecB-3ediA:
9.9		 3kecB-3ediA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 HIS A 227
GLU A 228
HIS A 231
 ZN  A 822 ( 3.5A)
00C  B  58 (-3.0A)
ZN  A 822 (-3.4A)
 0.15A 3kecB-3fiiA:
undetectable		 3kecB-3fiiA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5k PEPTIDE DEFORMYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01327
(Pep_deformylase) 		3 HIS A 156
GLU A 157
HIS A 160
 CO  A1002 ( 3.2A)
BB2  A1001 (-2.6A)
CO  A1002 ( 3.3A)
 0.19A 3kecB-3g5kA:
undetectable		 3kecB-3g5kA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6n PEPTIDE DEFORMYLASE

(Enterococcus
faecium) 		PF01327
(Pep_deformylase) 		3 HIS A 157
GLU A 158
HIS A 161
 FE  A 188 (-3.4A)
FE  A 188 ( 4.8A)
FE  A 188 (-3.5A)
 0.18A 3kecB-3g6nA:
undetectable		 3kecB-3g6nA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		3 HIS A 140
GLU A 141
HIS A 144
 ZN  A 302 (-3.3A)
ZN  A 302 ( 4.6A)
ZN  A 302 (-3.3A)
 0.22A 3kecB-3gboA:
10.2		 3kecB-3gboA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdb AAHIV

(Deinagkistrodon
acutus) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 333
GLU A 334
HIS A 337
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
 0.13A 3kecB-3hdbA:
9.9		 3kecB-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 341
GLU A 342
HIS A 345
 ZN  A 704 (-3.1A)
ZN  A 704 ( 4.5A)
ZN  A 704 (-3.3A)
 0.22A 3kecB-3k7nA:
10.2		 3kecB-3k7nA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 HIS A 374
GLU A 375
HIS A 378
 None
 0.18A 3kecB-3kbhA:
undetectable		 3kecB-3kbhA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 HIS E 423
GLU E 424
HIS E 427
 ZN  E 996 ( 3.3A)
NHX  E 998 (-3.0A)
ZN  E 996 ( 3.3A)
 0.19A 3kecB-3kdsE:
undetectable		 3kecB-3kdsE:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		3 HIS A 228
GLU A 229
HIS A 232
 ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
 0.19A 3kecB-3lunA:
8.0		 3kecB-3lunA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02

(Pseudoalteromonas
sp. SM9913) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		3 HIS A 345
GLU A 346
HIS A 349
 ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
ZN  A   1 (-3.2A)
 0.19A 3kecB-3nqxA:
3.1		 3kecB-3nqxA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o2x COLLAGENASE 3

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A1222
GLU A1223
HIS A1226
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
 0.07A 3kecB-3o2xA:
30.8		 3kecB-3o2xA:
99.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		3 HIS A 348
GLU A 349
HIS A 352
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.9A)
ZN  A 999 (-3.2A)
 0.14A 3kecB-3p24A:
8.5		 3kecB-3p24A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 149
GLU A 150
HIS A 153
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
 0.22A 3kecB-3q2hA:
10.3		 3kecB-3q2hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 3 HIS A 356
GLU A 357
HIS A 360
 ZN  A 568 ( 3.3A)
PO4  A 566 (-3.2A)
ZN  A 568 ( 3.3A)
 0.22A 3kecB-3sksA:
2.2		 3kecB-3sksA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u04 PEPTIDE DEFORMYLASE
1

(Ehrlichia
chaffeensis) 		PF01327
(Pep_deformylase) 		3 HIS A 153
GLU A 154
HIS A 157
 ZN  A 200 ( 3.3A)
BB2  A 210 (-2.7A)
ZN  A 200 ( 3.3A)
 0.22A 3kecB-3u04A:
undetectable		 3kecB-3u04A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwa RIIA-RIIB
MEMBRANE-ASSOCIATED
PROTEIN

(Synechococcus
phage S-SSM7) 		PF01327
(Pep_deformylase) 		3 HIS A 134
GLU A 135
HIS A 138
 ZN  A 200 (-3.3A)
ZN  A 200 ( 3.9A)
ZN  A 200 (-3.3A)
 0.22A 3kecB-3uwaA:
undetectable		 3kecB-3uwaA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v96 STROMELYSIN-2

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS B 217
GLU B 218
HIS B 221
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
 0.14A 3kecB-3v96B:
28.9		 3kecB-3v96B:
62.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		3 HIS A 176
GLU A 177
HIS A 180
 ZN  A 500 (-3.2A)
ZN  A 500 ( 4.2A)
ZN  A 500 (-3.3A)
 0.18A 3kecB-3vi1A:
13.3		 3kecB-3vi1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtg HIGH CHORIOLYTIC
ENZYME 1

(Oryzias latipes) 		PF01400
(Astacin) 		3 HIS A  99
GLU A 100
HIS A 103
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.3A)
ZN  A 301 (-3.3A)
 0.10A 3kecB-3vtgA:
10.3		 3kecB-3vtgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 HIS A 230
GLU A 231
HIS A 234
 ZN  A1440 (-3.3A)
ZN  A1440 ( 4.5A)
ZN  A1440 (-3.3A)
 0.14A 3kecB-3zuqA:
undetectable		 3kecB-3zuqA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 HIS A 223
GLU A 224
HIS A 227
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
 0.19A 3kecB-3zusA:
undetectable		 3kecB-3zusA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		3 HIS A 142
GLU A 143
HIS A 146
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
 0.17A 3kecB-4aigA:
10.6		 3kecB-4aigA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		3 HIS A 311
GLU A 312
HIS A 315
 ZN  A 502 ( 3.2A)
2PE  A 504 (-4.1A)
ZN  A 502 (-3.3A)
 0.18A 3kecB-4df9A:
5.7		 3kecB-4df9A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr9 PEPTIDE DEFORMYLASE

(Synechococcus
elongatus) 		PF01327
(Pep_deformylase) 		3 HIS A 151
GLU A 152
HIS A 155
 ZN  A 201 ( 3.3A)
BB2  A 203 (-2.6A)
ZN  A 201 ( 3.3A)
 0.14A 3kecB-4dr9A:
undetectable		 3kecB-4dr9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		3 HIS A 273
GLU A 274
HIS A 277
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
 0.22A 3kecB-4fgmA:
5.4		 3kecB-4fgmA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 HIS A 388
GLU A 389
HIS A 392
 None
 0.19A 3kecB-4fysA:
2.2		 3kecB-4fysA:
11.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gr8 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 218
GLU A 219
HIS A 222
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
 0.13A 3kecB-4gr8A:
27.3		 3kecB-4gr8A:
58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		3 HIS A 152
GLU A 153
HIS A 156
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
 0.13A 3kecB-4gwnA:
9.6		 3kecB-4gwnA:
16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4in9 KARILYSIN PROTEASE

(Tannerella
forsythia) 		PF00413
(Peptidase_M10) 		3 HIS A 155
GLU A 156
HIS A 159
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
 0.17A 3kecB-4in9A:
23.0		 3kecB-4in9A:
45.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		3 HIS A 233
GLU A 234
HIS A 237
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
 0.19A 3kecB-4j1lA:
undetectable		 3kecB-4j1lA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		3 HIS A 144
GLU A 145
HIS A 148
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.2A)
 0.11A 3kecB-4j4mA:
10.7		 3kecB-4j4mA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiu PROABYLYSIN

(Pyrococcus
abyssi) 		PF01863
(DUF45) 		3 HIS A  60
GLU A  61
HIS A  64
 ZN  A 201 (-3.2A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.12A 3kecB-4jiuA:
4.5		 3kecB-4jiuA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 HIS A 393
GLU A 394
HIS A 397
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
 0.21A 3kecB-4kxbA:
4.6		 3kecB-4kxbA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXA

(Escherichia
coli) 		PF16313
(DUF4953) 		3 HIS A 179
GLU A 180
HIS A 183
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
 0.10A 3kecB-4l63A:
11.3		 3kecB-4l63A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		3 HIS A 142
GLU A 143
HIS A 146
 ZN  A 302 (-3.2A)
ZN  A 302 ( 4.7A)
ZN  A 302 (-3.1A)
 0.20A 3kecB-4q1lA:
10.4		 3kecB-4q1lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 361
GLU A 362
HIS A 365
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
 0.20A 3kecB-4wk7A:
10.3		 3kecB-4wk7A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxl PEPTIDE DEFORMYLASE

(Haemophilus
influenzae) 		PF01327
(Pep_deformylase) 		3 HIS A 133
GLU A 134
HIS A 137
 NI  A 201 ( 3.3A)
BB2  A 202 (-2.8A)
NI  A 201 ( 3.2A)
 0.17A 3kecB-4wxlA:
undetectable		 3kecB-4wxlA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 226
GLU A 227
HIS A 230
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
 0.11A 3kecB-4xctA:
28.1		 3kecB-4xctA:
57.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		3 HIS A 367
GLU A 368
HIS A 371
 ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
 0.16A 3kecB-5a2rA:
3.5		 3kecB-5a2rA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		3 HIS A 142
GLU A 143
HIS A 146
 ZN  A 301 ( 3.4A)
ZN  A 301 ( 4.2A)
ZN  A 301 ( 3.3A)
 0.12A 3kecB-5czwA:
11.0		 3kecB-5czwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		3 HIS A 253
GLU A 254
HIS A 257
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
 0.19A 3kecB-5e3xA:
2.3		 3kecB-5e3xA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		3 HIS A 266
GLU A 267
HIS A 270
 ZN  A 601 (-3.4A)
ZN  A 601 ( 4.7A)
ZN  A 601 (-3.4A)
 0.15A 3kecB-5givA:
2.4		 3kecB-5givA:
18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h0u MATRIX
METALLOPROTEINASE-14

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 239
GLU A 240
HIS A 243
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
 0.12A 3kecB-5h0uA:
27.4		 3kecB-5h0uA:
48.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqj UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		no annotation 3 HIS A  10
GLU A  11
HIS A  14
 None
TTN  A 204 ( 4.6A)
None
 0.20A 3kecB-5iqjA:
undetectable		 3kecB-5iqjA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		3 HIS A 574
GLU A 575
HIS A 578
 ZN  A 901 ( 3.3A)
EDO  A 904 (-2.4A)
ZN  A 901 ( 3.2A)
 0.22A 3kecB-5kd5A:
undetectable		 3kecB-5kd5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 3 HIS B 756
GLU B 757
HIS B 760
 ZN  B1103 (-3.3A)
ZN  B1103 ( 4.3A)
ZN  B1103 (-3.4A)
 0.19A 3kecB-5kdjB:
2.4		 3kecB-5kdjB:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		3 HIS A 696
GLU A 697
HIS A 700
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
 0.20A 3kecB-5kdxA:
undetectable		 3kecB-5kdxA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kob PEPTIDE DEFORMYLASE

(Paraburkholderia
xenovorans) 		PF01327
(Pep_deformylase) 		3 HIS A 141
GLU A 142
HIS A 145
 FE2  A 201 (-3.3A)
FE2  A 201 ( 4.2A)
FE2  A 201 (-3.4A)
 0.22A 3kecB-5kobA:
undetectable		 3kecB-5kobA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 HIS A 233
GLU A 234
HIS A 237
 ZN  A1406 (-3.5A)
ZN  A1406 ( 4.4A)
ZN  A1406 (-3.4A)
 0.15A 3kecB-5n0cA:
undetectable		 3kecB-5n0cA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 3 HIS A 455
GLU A 456
HIS A 459
 ZN  A 801 ( 3.3A)
9NB  A 803 (-3.5A)
9NB  A 803 ( 3.2A)
 0.07A 3kecB-5o7eA:
4.3		 3kecB-5o7eA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG

(Homo sapiens) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		3 HIS A 335
GLU A 336
HIS A 339
 ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
ZN  A 517 (-3.2A)
 0.22A 3kecB-5sytA:
undetectable		 3kecB-5sytA:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 401
GLU A 402
HIS A 405
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
 0.15A 3kecB-5th6A:
23.9		 3kecB-5th6A:
44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbn WSS1P

(Saccharomyces
cerevisiae) 		no annotation 3 HIS A 115
GLU A 116
HIS A 119
 ZN  A 201 (-3.2A)
ZN  A 201 ( 4.7A)
ZN  A 201 (-3.3A)
 0.15A 3kecB-5xbnA:
4.7		 3kecB-5xbnA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 3 HIS A 443
GLU A 444
HIS A 448
 ZN  A 801 (-3.2A)
GOL  A 804 (-3.9A)
ZN  A 801 (-3.1A)
 0.22A 3kecB-5yfbA:
undetectable		 3kecB-5yfbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btp -

(-) 		no annotation 3 HIS A  93
GLU A  94
HIS A  97
 ZN  A 302 ( 3.3A)
E8J  A 304 (-2.6A)
ZN  A 302 ( 3.4A)
 0.12A 3kecB-6btpA:
9.7		 3kecB-6btpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvd LIGHT CHAIN

(Clostridium
botulinum) 		no annotation 3 HIS A 226
GLU A 227
HIS A 230
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
 0.17A 3kecB-6bvdA:
undetectable		 3kecB-6bvdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 3 HIS A 227
GLU A 228
HIS A 231
 None
 0.20A 3kecB-6f4eA:
undetectable		 3kecB-6f4eA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpc PRO-PRO
ENDOPEPTIDASE

(Paenibacillus
alvei) 		no annotation 3 HIS A 137
GLU A 138
HIS A 141
 ZN  A 301 ( 3.4A)
ZN  A 301 ( 4.3A)
ZN  A 301 ( 3.4A)
 0.18A 3kecB-6fpcA:
2.6		 3kecB-6fpcA:
18.18