SIMILAR PATTERNS OF AMINO ACIDS FOR 3KDM_H_TESH226

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fh5 MONOCLONAL ANTIBODY
MAK33

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TRP H  44
TYR H  56
ASP H  96
TYR H  30
MET H 107
 None
 1.49A 3kdmH-1fh5H:
23.3
3kdmL-1fh5H:
14.8		 3kdmH-1fh5H:
67.28
3kdmL-1fh5H:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qkz ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TRP H  47
TYR H  58
ASP H  95
TYR H  33
MET H 100
 None
 1.40A 3kdmH-1qkzH:
22.6
3kdmL-1qkzH:
16.8		 3kdmH-1qkzH:
68.61
3kdmL-1qkzH:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN

(Yersinia pestis) 		PF07201
(HrpJ) 		5 SER A 133
ALA A 178
TYR A  90
TYR A 202
PRO A 182
 None
None
None
None
MLY  A  93 ( 4.8A)
 1.21A 3kdmH-1xkpA:
undetectable
3kdmL-1xkpA:
undetectable		 3kdmH-1xkpA:
22.43
3kdmL-1xkpA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ux9 SCFV ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		5 SER B 169
TRP B 181
ALA B 184
TYR B 193
MET B 240
 None
 0.75A 3kdmH-3ux9B:
14.2
3kdmL-3ux9B:
21.4		 3kdmH-3ux9B:
66.47
3kdmL-3ux9B:
39.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 SER A 147
TRP A 149
ALA A 148
TYR A 162
TYR A 213
 None
 1.37A 3kdmH-4m8uA:
0.0
3kdmL-4m8uA:
0.0		 3kdmH-4m8uA:
15.28
3kdmL-4m8uA:
15.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u1g QA1 MONOCLONAL
ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TRP B  47
TYR B  59
ASP B  99
TYR B  33
MET B 109
 None
 1.45A 3kdmH-4u1gB:
25.4
3kdmL-4u1gB:
15.3		 3kdmH-4u1gB:
65.65
3kdmL-4u1gB:
27.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uu9 MEDI7814

(Homo sapiens) 		PF07686
(V-set) 		5 SER A  35
TRP A  47
ALA A  50
TYR A  58
MET A 100
 None
 0.59A 3kdmH-4uu9A:
22.3
3kdmL-4uu9A:
13.4		 3kdmH-4uu9A:
92.68
3kdmL-4uu9A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b71 SKY59 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TRP B  48
ALA B  51
TYR B  60
ASP B 100
MET B 110
 None
 1.28A 3kdmH-5b71B:
23.1
3kdmL-5b71B:
14.5		 3kdmH-5b71B:
76.55
3kdmL-5b71B:
30.67