SIMILAR PATTERNS OF AMINO ACIDS FOR 3K9W_A_ACTA170_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR


(Escherichia
coli)
PF12849
(PBP_like_2)
3 SER A 139
GLY A 140
THR A 141
PO4  A 322 ( 2.6A)
PO4  A 322 ( 3.4A)
PO4  A 322 ( 3.5A)
0.10A 3k9wA-1a40A:
undetectable
3k9wA-1a40A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dih DIHYDRODIPICOLINATE
REDUCTASE


(Escherichia
coli)
PF01113
(DapB_N)
PF05173
(DapB_C)
3 SER A 168
GLY A 169
THR A 170
None
0.19A 3k9wA-1dihA:
3.8
3k9wA-1dihA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dyo ENDO-1,4-BETA-XYLANA
SE Y


(Ruminiclostridium
thermocellum)
PF02018
(CBM_4_9)
3 SER A  98
GLY A  99
THR A 100
None
0.19A 3k9wA-1dyoA:
undetectable
3k9wA-1dyoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli)
PF01728
(FtsJ)
3 SER A 130
GLY A 131
THR A 132
None
0.24A 3k9wA-1eizA:
undetectable
3k9wA-1eizA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9a HYPOTHETICAL PROTEIN
MJ0541


(Methanocaldococcus
jannaschii)
PF01467
(CTP_transf_like)
3 SER A 125
GLY A 126
THR A 127
ATP  A 700 (-4.3A)
ATP  A 700 (-3.7A)
ATP  A 700 (-3.8A)
0.20A 3k9wA-1f9aA:
16.4
3k9wA-1f9aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7g 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Escherichia
coli)
PF02348
(CTP_transf_3)
3 SER A  75
GLY A  76
THR A  77
None
0.22A 3k9wA-1h7gA:
4.2
3k9wA-1h7gA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyb NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYLTRANSFERASE


(Methanothermobacter
thermautotrophicus)
PF01467
(CTP_transf_like)
3 SER A 131
GLY A 132
THR A 133
SO4  A1759 ( 4.2A)
SO4  A1759 (-3.1A)
SO4  A1759 (-3.8A)
0.22A 3k9wA-1hybA:
15.6
3k9wA-1hybA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum)
PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 SER A 358
GLY A 359
THR A 360
None
0.11A 3k9wA-1i2dA:
9.5
3k9wA-1i2dA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00266
(Aminotran_5)
3 SER A  59
GLY A  60
THR A  61
LLP  A 185 ( 2.8A)
LLP  A 185 ( 3.7A)
LLP  A 185 ( 3.6A)
0.21A 3k9wA-1iugA:
2.0
3k9wA-1iugA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN


(Thermotoga
maritima)
PF01975
(SurE)
3 SER A 107
GLY A 108
THR A 109
VO4  A 401 (-2.6A)
VO4  A 401 (-3.9A)
VO4  A 401 (-3.4A)
0.09A 3k9wA-1j9lA:
3.2
3k9wA-1j9lA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 SER A 357
GLY A 358
THR A 359
None
0.11A 3k9wA-1jedA:
9.8
3k9wA-1jedA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1


(Streptomyces
coelicolor)
PF01183
(Glyco_hydro_25)
3 SER A  71
GLY A  72
THR A  73
None
0.12A 3k9wA-1jfxA:
undetectable
3k9wA-1jfxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE


(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 SER A 360
GLY A 361
THR A 362
None
SO4  A1002 (-3.6A)
None
0.17A 3k9wA-1jhdA:
9.1
3k9wA-1jhdA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L18E


(Haloarcula
marismortui)
PF00828
(Ribosomal_L27A)
3 SER P  82
GLY P  83
THR P  84
A  A 660 ( 2.8A)
A  A 659 ( 3.9A)
A  A 660 ( 3.4A)
0.19A 3k9wA-1kc8P:
undetectable
3k9wA-1kc8P:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpt KP4 TOXIN

(Ustilago maydis)
PF09044
(Kp4)
3 SER A  62
GLY A  63
THR A  64
None
0.12A 3k9wA-1kptA:
undetectable
3k9wA-1kptA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum)
PF01975
(SurE)
3 SER A 106
GLY A 107
THR A 108
None
0.12A 3k9wA-1l5xA:
3.4
3k9wA-1l5xA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6s L-ALLO-THREONINE
ALDOLASE


(Thermotoga
maritima)
PF01212
(Beta_elim_lyase)
3 SER A  57
GLY A  58
THR A  59
LLP  A 199 ( 3.9A)
LLP  A 199 ( 3.3A)
LLP  A 199 ( 3.5A)
0.16A 3k9wA-1m6sA:
undetectable
3k9wA-1m6sA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN


(Thermus
thermophilus)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
3 SER A 153
GLY A 154
THR A 155
None
0.15A 3k9wA-1oi7A:
3.2
3k9wA-1oi7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 SER A 357
GLY A 358
THR A 359
None
0.18A 3k9wA-1r6xA:
9.0
3k9wA-1r6xA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
3 SER A  91
GLY A  92
THR A  93
None
0.16A 3k9wA-1rf5A:
undetectable
3k9wA-1rf5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rli TRP REPRESSOR
BINDING PROTEIN


(Bacillus
subtilis)
PF03358
(FMN_red)
3 SER A  84
GLY A  85
THR A  86
None
0.17A 3k9wA-1rliA:
2.4
3k9wA-1rliA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Vibrio cholerae)
PF12727
(PBP_like)
3 SER A 153
GLY A 154
THR A 155
None
PO4  A1500 ( 3.7A)
None
0.10A 3k9wA-1twyA:
undetectable
3k9wA-1twyA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcb PROTEIN (ELONGIN C)

(Homo sapiens)
PF03931
(Skp1_POZ)
3 SER B  39
GLY B  40
THR B  41
None
0.04A 3k9wA-1vcbB:
undetectable
3k9wA-1vcbB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
3 SER A 112
GLY A 113
THR A 114
PLP  A 513 ( 4.0A)
PLP  A 513 (-3.2A)
PLP  A 513 (-3.8A)
0.21A 3k9wA-1vefA:
undetectable
3k9wA-1vefA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1


(Homo sapiens)
no annotation 3 SER B 587
GLY B 588
THR B 589
None
0.22A 3k9wA-1xnjB:
9.6
3k9wA-1xnjB:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA


(Mycobacterium
tuberculosis)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
3 SER A 354
GLY A 355
THR A 356
None
0.11A 3k9wA-1zj9A:
undetectable
3k9wA-1zj9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE


(Pseudomonas
stutzeri)
PF00202
(Aminotran_3)
3 SER A 121
GLY A 122
THR A 123
None
0.12A 3k9wA-2cy8A:
undetectable
3k9wA-2cy8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
3 SER A 116
GLY A 117
THR A 118
PMP  A1001 (-3.7A)
PMP  A1001 (-3.5A)
PMP  A1001 (-3.6A)
0.14A 3k9wA-2e7uA:
undetectable
3k9wA-2e7uA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE


(Aquifex
aeolicus)
PF00202
(Aminotran_3)
3 SER A  94
GLY A  95
THR A  96
PLP  A1001 (-3.9A)
PLP  A1001 (-3.3A)
PLP  A1001 (-3.5A)
0.21A 3k9wA-2eh6A:
undetectable
3k9wA-2eh6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE


(Sulfurisphaera
tokodaii)
PF00202
(Aminotran_3)
3 SER A 112
GLY A 113
THR A 114
PLP  A1001 ( 3.8A)
PLP  A1001 ( 3.4A)
PLP  A1001 ( 3.8A)
0.21A 3k9wA-2eo5A:
undetectable
3k9wA-2eo5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Aeropyrum
pernix)
PF00202
(Aminotran_3)
3 SER A 120
GLY A 121
THR A 122
PMP  A 501 ( 3.8A)
PMP  A 501 ( 3.3A)
PMP  A 501 ( 3.5A)
0.18A 3k9wA-2epjA:
undetectable
3k9wA-2epjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE


(Sulfurisphaera
tokodaii)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
3 SER A 423
GLY A 424
THR A 425
SO4  A 460 (-3.5A)
SO4  A 460 (-3.8A)
SO4  A 460 (-4.1A)
0.19A 3k9wA-2f7lA:
undetectable
3k9wA-2f7lA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
3 SER A 122
GLY A 123
THR A 124
None
0.17A 3k9wA-2nztA:
undetectable
3k9wA-2nztA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00202
(Aminotran_3)
3 SER A 107
GLY A 108
THR A 109
PLP  A 555 (-3.6A)
PLP  A 555 (-3.3A)
PLP  A 555 ( 3.5A)
0.15A 3k9wA-2pb0A:
undetectable
3k9wA-2pb0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens)
PF12849
(PBP_like_2)
3 SER A 145
GLY A 146
THR A 147
PO4  A 901 (-2.6A)
PO4  A 901 (-3.6A)
PO4  A 901 (-3.6A)
0.07A 3k9wA-2q9tA:
undetectable
3k9wA-2q9tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnl UNCHARACTERIZED
PROTEIN


(Cytophaga
hutchinsonii)
PF12867
(DinB_2)
3 SER A  45
GLY A  46
THR A  47
None
0.18A 3k9wA-2qnlA:
undetectable
3k9wA-2qnlA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4n MULTIFUNCTIONAL
PROTEIN SUR E


(Salmonella
enterica)
PF01975
(SurE)
3 SER A 104
GLY A 105
THR A 106
PO4  A1257 ( 3.9A)
None
None
0.21A 3k9wA-2v4nA:
2.5
3k9wA-2v4nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri)
PF01979
(Amidohydro_1)
3 SER A 279
GLY A 280
THR A 281
None
0.17A 3k9wA-2vunA:
undetectable
3k9wA-2vunA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqk 5'-NUCLEOTIDASE SURE

(Aquifex
aeolicus)
PF01975
(SurE)
3 SER A 106
GLY A 107
THR A 108
SO4  A 252 (-2.8A)
SO4  A 252 (-3.8A)
SO4  A 252 (-3.7A)
0.09A 3k9wA-2wqkA:
2.7
3k9wA-2wqkA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK)
PF00202
(Aminotran_3)
3 SER A 144
GLY A 145
THR A 146
PLP  A1446 (-3.8A)
PLP  A1446 (-3.2A)
PLP  A1446 (-3.5A)
0.23A 3k9wA-2ykyA:
undetectable
3k9wA-2ykyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN


(Yersinia pestis)
no annotation 3 SER X 139
GLY X 140
THR X 141
PO4  X2322 (-2.5A)
PO4  X2322 (-3.4A)
PO4  X2322 (-3.6A)
0.11A 3k9wA-2z22X:
undetectable
3k9wA-2z22X:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Bacillus
subtilis)
PF00202
(Aminotran_3)
3 SER A 117
GLY A 118
THR A 119
PMP  A 431 ( 3.8A)
PMP  A 431 (-3.6A)
PMP  A 431 (-3.4A)
0.15A 3k9wA-3bs8A:
undetectable
3k9wA-3bs8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00266
(Aminotran_5)
3 SER A 167
GLY A 168
THR A 169
None
0.18A 3k9wA-3caiA:
undetectable
3k9wA-3caiA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE


(Listeria
innocua)
PF06838
(Met_gamma_lyase)
3 SER A  84
GLY A  85
THR A  86
LLP  A 226 ( 3.3A)
LLP  A 226 ( 3.5A)
LLP  A 226 ( 3.6A)
0.08A 3k9wA-3fd0A:
undetectable
3k9wA-3fd0A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Synechococcus
elongatus)
PF00202
(Aminotran_3)
3 SER A1122
GLY A1123
THR A1124
PMP  A5000 (-3.8A)
PMP  A5000 (-3.3A)
PMP  A5000 (-3.5A)
0.12A 3k9wA-3fq8A:
undetectable
3k9wA-3fq8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1


(Klebsiella
pneumoniae)
PF00563
(EAL)
PF04940
(BLUF)
3 SER A 335
GLY A 336
THR A 337
None
0.16A 3k9wA-3gg0A:
undetectable
3k9wA-3gg0A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951


(Methanocaldococcus
jannaschii)
PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass)
3 SER A 226
GLY A 227
THR A 228
None
0.12A 3k9wA-3gmiA:
11.7
3k9wA-3gmiA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i42 RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY-LIKE)


(Methylobacillus
flagellatus)
PF00072
(Response_reg)
3 SER A  50
GLY A  51
THR A  52
None
0.20A 3k9wA-3i42A:
3.3
3k9wA-3i42A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijp DIHYDRODIPICOLINATE
REDUCTASE


(Bartonella
henselae)
PF01113
(DapB_N)
PF05173
(DapB_C)
3 SER A 163
GLY A 164
THR A 165
UNX  A 271 ( 4.9A)
UNX  A 271 ( 3.7A)
UNX  A 270 ( 4.5A)
0.16A 3k9wA-3ijpA:
3.6
3k9wA-3ijpA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1)
no annotation 3 SER A  79
GLY A  80
THR A  81
None
0.09A 3k9wA-3j31A:
undetectable
3k9wA-3j31A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Yersinia pestis)
PF02348
(CTP_transf_3)
3 SER A  74
GLY A  75
THR A  76
None
None
IMD  A 301 (-4.3A)
0.22A 3k9wA-3jtjA:
2.7
3k9wA-3jtjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE


(Listeria
monocytogenes)
PF06838
(Met_gamma_lyase)
3 SER A  84
GLY A  85
THR A  86
LLP  A 226 ( 3.3A)
LLP  A 226 ( 3.5A)
LLP  A 226 ( 3.4A)
0.03A 3k9wA-3jzlA:
undetectable
3k9wA-3jzlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2


(Bacillus
anthracis)
PF00202
(Aminotran_3)
3 SER A 117
GLY A 118
THR A 119
PLP  A 900 (-4.0A)
PLP  A 900 (-3.3A)
PLP  A 900 (-3.7A)
0.14A 3k9wA-3k28A:
undetectable
3k9wA-3k28A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE


(Psychrobacter
arcticus)
PF00266
(Aminotran_5)
3 SER A  58
GLY A  59
THR A  60
LLP  A 198 ( 2.9A)
LLP  A 198 ( 3.6A)
LLP  A 198 ( 3.6A)
0.21A 3k9wA-3ke3A:
undetectable
3k9wA-3ke3A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1


(Bacillus
anthracis)
PF00202
(Aminotran_3)
3 SER A 119
GLY A 120
THR A 121
LLP  A 270 ( 3.9A)
LLP  A 270 ( 3.2A)
LLP  A 270 ( 3.5A)
0.17A 3k9wA-3l44A:
undetectable
3k9wA-3l44A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr1 TUNGSTATE ABC
TRANSPORTER,
PERIPLASMIC
TUNGSTATE-BINDING
PROTEIN


(Geobacter
sulfurreducens)
PF12849
(PBP_like_2)
3 SER A 122
GLY A 123
THR A 124
W  A 234 ( 4.7A)
None
None
0.18A 3k9wA-3lr1A:
undetectable
3k9wA-3lr1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus)
PF01676
(Metalloenzyme)
3 SER A 131
GLY A 132
THR A 133
None
0.12A 3k9wA-3m8yA:
undetectable
3k9wA-3m8yA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN


(Homo sapiens;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 SER A 127
GLY A 128
THR A 129
None
0.17A 3k9wA-3mnzA:
undetectable
3k9wA-3mnzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN


(Vibrio
parahaemolyticus)
PF12849
(PBP_like_2)
3 SER A 147
GLY A 148
THR A 149
None
0.19A 3k9wA-3muqA:
undetectable
3k9wA-3muqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvg RIBOSOME
INACTIVATING TYPE 1
PROTEIN


(Iris x
hollandica)
PF00161
(RIP)
3 SER A  29
GLY A  30
THR A  31
SO4  A 276 ( 4.8A)
GOL  A 277 ( 3.7A)
None
0.23A 3k9wA-3mvgA:
undetectable
3k9wA-3mvgA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE


(Campylobacter
jejuni)
PF00202
(Aminotran_3)
3 SER A 101
GLY A 102
THR A 103
None
0.19A 3k9wA-3nx3A:
undetectable
3k9wA-3nx3A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2k BREVIANAMIDE F
PRENYLTRANSFERASE


(Aspergillus
fumigatus)
PF11991
(Trp_DMAT)
3 SER A 195
GLY A 196
THR A 197
None
0.23A 3k9wA-3o2kA:
undetectable
3k9wA-3o2kA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oam 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Vibrio cholerae)
PF02348
(CTP_transf_3)
3 SER A  74
GLY A  75
THR A  76
None
0.24A 3k9wA-3oamA:
3.9
3k9wA-3oamA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE


(Burkholderia
pseudomallei)
PF01467
(CTP_transf_like)
3 SER A 127
GLY A 128
THR A 129
SO4  A 205 (-3.0A)
SO4  A 205 (-3.8A)
SO4  A 205 (-4.3A)
0.05A 3k9wA-3pxuA:
30.8
3k9wA-3pxuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy9 DIHYDRODIPICOLINATE
REDUCTASE


(Staphylococcus
aureus)
PF01113
(DapB_N)
PF05173
(DapB_C)
3 SER A 144
GLY A 145
THR A 146
SO4  A 242 (-3.7A)
SO4  A 242 (-3.6A)
SO4  A 242 (-3.9A)
0.22A 3k9wA-3qy9A:
2.2
3k9wA-3qy9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1


(Bacillus
halodurans)
PF00275
(EPSP_synthase)
3 SER A  96
GLY A  97
THR A  98
SO4  A 500 ( 4.0A)
SO4  A 500 (-3.4A)
SO4  A 507 (-3.6A)
0.17A 3k9wA-3rmtA:
undetectable
3k9wA-3rmtA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpi LIGHT CHAIN FROM
HIGHLY POTENT
ANTI-HIV
NEUTRALIZING
ANTIBODY


(Homo sapiens)
no annotation 3 SER L 116
GLY L 117
THR L 118
None
0.24A 3k9wA-3rpiL:
undetectable
3k9wA-3rpiL:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty2 5'-NUCLEOTIDASE SURE

(Coxiella
burnetii)
PF01975
(SurE)
3 SER A 114
GLY A 115
THR A 116
None
0.08A 3k9wA-3ty2A:
3.2
3k9wA-3ty2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN


(unidentified
prokaryotic
organism)
PF12849
(PBP_like_2)
3 SER A 144
GLY A 145
THR A 146
PO4  A 401 (-2.7A)
PO4  A 401 (-3.6A)
PO4  A 401 (-3.6A)
0.09A 3k9wA-3w9vA:
undetectable
3k9wA-3w9vA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE


(Aeromonas
jandaei)
PF01212
(Beta_elim_lyase)
3 SER A  59
GLY A  60
THR A  61
PLG  A 401 (-3.6A)
PLG  A 401 (-3.2A)
PLG  A 401 (-3.8A)
0.19A 3k9wA-3wgcA:
undetectable
3k9wA-3wgcA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqb OPEN READING FRAME 2

(Aeromonas
sobria)
no annotation 3 SER B  63
GLY B  64
THR B  65
None
0.20A 3k9wA-3wqbB:
undetectable
3k9wA-3wqbB:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE


(Variovorax
paradoxus)
PF00202
(Aminotran_3)
3 SER A 131
GLY A 132
THR A 133
IK2  A1435 (-3.8A)
IK2  A1435 (-3.4A)
IK2  A1435 (-3.6A)
0.15A 3k9wA-4aoaA:
undetectable
3k9wA-4aoaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE


(Allochromatium
vinosum)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 SER A 360
GLY A 361
THR A 362
None
0.17A 3k9wA-4dnxA:
9.0
3k9wA-4dnxA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Yersinia pestis)
PF00202
(Aminotran_3)
3 SER A 114
GLY A 115
THR A 116
NO3  A 502 (-4.7A)
NO3  A 502 (-3.5A)
None
0.04A 3k9wA-4e77A:
undetectable
3k9wA-4e77A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Lactobacillus
brevis)
PF12849
(PBP_like_2)
3 SER A 160
GLY A 161
THR A 162
PO4  A 300 (-2.6A)
PO4  A 300 (-3.6A)
PO4  A 300 (-3.5A)
0.06A 3k9wA-4ecfA:
undetectable
3k9wA-4ecfA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcu 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Acinetobacter
baumannii)
PF02348
(CTP_transf_3)
3 SER A  74
GLY A  75
THR A  76
None
0.09A 3k9wA-4fcuA:
2.7
3k9wA-4fcuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6a AP33 LIGHT CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 SER D 127
GLY D 128
THR D 129
None
0.19A 3k9wA-4g6aD:
undetectable
3k9wA-4g6aD:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN


(Clostridium
perfringens)
PF12849
(PBP_like_2)
3 SER A 159
GLY A 160
THR A 161
PO4  A 301 (-2.7A)
PO4  A 301 (-3.5A)
PO4  A 301 (-3.6A)
0.08A 3k9wA-4gd5A:
undetectable
3k9wA-4gd5A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2


(Streptococcus
pneumoniae)
PF12849
(PBP_like_2)
3 SER A  46
GLY A  47
THR A  48
CIT  A 302 (-2.5A)
CIT  A 302 (-3.2A)
CIT  A 302 (-3.3A)
0.08A 3k9wA-4h1xA:
undetectable
3k9wA-4h1xA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 SER L 241
GLY L 242
THR L 243
None
0.20A 3k9wA-4hjjL:
undetectable
3k9wA-4hjjL:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Rickettsia
bellii)
PF02350
(Epimerase_2)
3 SER A 282
GLY A 283
THR A 284
None
0.24A 3k9wA-4hwgA:
4.2
3k9wA-4hwgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae)
PF00266
(Aminotran_5)
3 SER A  71
GLY A  72
THR A  73
LLP  A 196 ( 3.8A)
LLP  A 196 ( 3.5A)
LLP  A 196 ( 3.6A)
0.18A 3k9wA-4ixoA:
undetectable
3k9wA-4ixoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwo PHOSPHATE BINDING
PROTEIN


(Planctopirus
limnophila)
PF12727
(PBP_like)
3 SER A 194
GLY A 195
THR A 196
None
0.19A 3k9wA-4jwoA:
undetectable
3k9wA-4jwoA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA


(Bacillus
subtilis)
PF01041
(DegT_DnrJ_EryC1)
3 SER A 124
GLY A 125
THR A 126
LLP  A 247 ( 3.7A)
LLP  A 247 ( 3.2A)
LLP  A 247 ( 3.6A)
0.14A 3k9wA-4k2bA:
undetectable
3k9wA-4k2bA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE


(Burkholderia
cenocepacia)
PF01041
(DegT_DnrJ_EryC1)
3 SER A  60
GLY A  61
THR A  62
CIT  A 401 (-3.8A)
CIT  A 401 (-3.5A)
CIT  A 401 ( 3.7A)
0.22A 3k9wA-4lc3A:
undetectable
3k9wA-4lc3A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3


(Mycobacterium
tuberculosis)
PF12849
(PBP_like_2)
3 SER A 191
GLY A 192
THR A 193
PO4  A 401 (-2.6A)
PO4  A 401 (-3.4A)
PO4  A 401 (-4.2A)
0.13A 3k9wA-4lvqA:
undetectable
3k9wA-4lvqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maf ATP SULFURYLASE

(Glycine max)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 SER A 414
GLY A 415
THR A 416
None
0.09A 3k9wA-4mafA:
9.7
3k9wA-4mafA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans)
PF01676
(Metalloenzyme)
3 SER A 140
GLY A 141
THR A 142
None
SO4  A 503 (-3.2A)
None
0.20A 3k9wA-4n7tA:
undetectable
3k9wA-4n7tA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN


(Pseudomonas
aeruginosa)
PF12849
(PBP_like_2)
3 SER A 185
GLY A 186
THR A 187
PO4  A 401 (-2.5A)
PO4  A 401 (-3.4A)
PO4  A 401 (-3.5A)
0.12A 3k9wA-4ombA:
undetectable
3k9wA-4ombA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqj PHOSPHATE BINDING
PROTEIN


(Pseudomonas
aeruginosa)
PF12849
(PBP_like_2)
3 SER A 185
GLY A 186
THR A 187
PO4  A 401 (-2.6A)
PO4  A 401 (-3.4A)
PO4  A 401 (-3.5A)
0.14A 3k9wA-4pqjA:
undetectable
3k9wA-4pqjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN


(Clostridium
perfringens)
PF12849
(PBP_like_2)
3 SER A 129
GLY A 130
THR A 131
PO4  A 301 (-2.6A)
PO4  A 301 (-3.5A)
PO4  A 301 (-3.6A)
0.07A 3k9wA-4q8rA:
undetectable
3k9wA-4q8rA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Actinobacillus
pleuropneumoniae)
PF13343
(SBP_bac_6)
3 SER A 148
GLY A 149
THR A 150
GOL  A 402 (-2.5A)
GOL  A 402 (-4.0A)
GOL  A 402 (-3.7A)
0.11A 3k9wA-4r72A:
undetectable
3k9wA-4r72A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
3 SER A 593
GLY A 594
THR A 595
None
0.17A 3k9wA-4w8jA:
undetectable
3k9wA-4w8jA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF02348
(CTP_transf_3)
3 SER A  76
GLY A  77
THR A  78
None
0.21A 3k9wA-4xwiA:
3.3
3k9wA-4xwiA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydk LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 SER L 127
GLY L 128
THR L 129
None
0.24A 3k9wA-4ydkL:
undetectable
3k9wA-4ydkL:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Pseudomonas
aeruginosa)
PF01113
(DapB_N)
PF05173
(DapB_C)
3 SER A 165
GLY A 166
THR A 167
None
0.12A 3k9wA-4ywjA:
3.2
3k9wA-4ywjA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg5 5'-NUCLEOTIDASE SURE

(Brucella
abortus)
no annotation 3 SER D 104
GLY D 105
THR D 106
None
0.11A 3k9wA-4zg5D:
2.9
3k9wA-4zg5D:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum)
PF00202
(Aminotran_3)
3 SER A 119
GLY A 120
THR A 121
PLP  A 501 (-4.1A)
PLP  A 501 (-3.2A)
PLP  A 501 (-3.4A)
0.21A 3k9wA-4zm4A:
undetectable
3k9wA-4zm4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE


(Actinomadura
melliaura)
PF01041
(DegT_DnrJ_EryC1)
3 SER A  53
GLY A  54
THR A  55
LLP  A 187 ( 3.7A)
LLP  A 187 ( 3.4A)
LLP  A 187 ( 3.6A)
0.16A 3k9wA-4zwvA:
undetectable
3k9wA-4zwvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE


(Caulobacter
vibrioides)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 SER A  39
GLY A  40
THR A  41
NDP  A1340 (-2.5A)
NDP  A1340 (-3.5A)
NDP  A1340 (-3.6A)
0.23A 3k9wA-5a05A:
2.5
3k9wA-5a05A:
24.54