SIMILAR PATTERNS OF AMINO ACIDS FOR 3K8M_B_ACRB830

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ija ARYLAMINE
N-ACETYLTRANSFERASE
1

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		4 ARG A 151
TYR A 160
LYS A 188
ASP A 162
 None
 0.96A 3k8mB-2ijaA:
0.0		 3k8mB-2ijaA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkf ALDOLASE LSRF

(Escherichia
coli) 		no annotation 4 ARG O 185
TYR O 186
LYS O 182
ASP O 183
 None
 1.27A 3k8mB-3gkfO:
7.9		 3k8mB-3gkfO:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 ARG A 457
TRP A 460
TYR A 469
LYS A 472
ASP A 473
 ACT  A 972 (-3.9A)
ACT  A 972 (-4.1A)
None
None
None
 0.35A 3k8mB-3k8kA:
65.9		 3k8mB-3k8kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		4 ARG A 281
TYR A 284
LYS A 288
ASP A 285
 None
 1.16A 3k8mB-4rxtA:
0.7		 3k8mB-4rxtA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjz SCFV H2526

(Homo sapiens) 		PF07686
(V-set) 		4 ARG L  39
TYR L  87
LYS L 106
ASP L  86
 None
 1.49A 3k8mB-4yjzL:
0.7		 3k8mB-4yjzL:
17.30