SIMILAR PATTERNS OF AMINO ACIDS FOR 3K8M_B_ACRB820_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aa2 BETA-SPECTRIN

(Homo sapiens) 		PF00307
(CH) 		4 GLU A  92
TRP A  31
LEU A  40
TRP A  11
 None
 1.42A 3k8mB-1aa2A:
undetectable		 3k8mB-1aa2A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cij PROTEIN (HALOALKANE
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00561
(Abhydrolase_1) 		4 TYR A  18
GLU A  41
LEU A  15
TRP A  59
 None
 1.34A 3k8mB-1cijA:
undetectable		 3k8mB-1cijA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 GLU A 230
LEU A 164
TRP A 123
ASN A 214
 None
 1.20A 3k8mB-1ldjA:
undetectable		 3k8mB-1ldjA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 TYR A 121
GLU A   2
LEU A 122
ASN A 228
 None
 1.29A 3k8mB-1miqA:
undetectable		 3k8mB-1miqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk7 TALIN

(Gallus gallus) 		PF00373
(FERM_M)
PF02174
(IRS) 		4 TYR B 241
GLU B 293
LEU B 301
LYS B 234
 None
 1.38A 3k8mB-1mk7B:
undetectable		 3k8mB-1mk7B:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6

(Saccharopolyspora
erythraea) 		PF00975
(Thioesterase) 		4 TYR A 149
TRP A 216
LEU A 146
TRP A 246
 None
 1.23A 3k8mB-1mo2A:
undetectable		 3k8mB-1mo2A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 GLU A 222
LEU A 202
TRP A 183
ASN A 229
 None
 1.42A 3k8mB-1qnrA:
11.4		 3k8mB-1qnrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9p RUBREDOXIN

(Clostridium
pasteurianum) 		PF00301
(Rubredoxin) 		4 TYR A  13
GLU A  16
TRP A  37
LYS A  46
 None
 1.19A 3k8mB-1t9pA:
undetectable		 3k8mB-1t9pA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 TYR A 245
GLU A 366
LEU A 242
ASN A 239
 None
 1.40A 3k8mB-1up4A:
undetectable		 3k8mB-1up4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vio RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A

(Haemophilus
influenzae) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		4 TYR A  62
GLU A  59
LEU A 222
TRP A 117
 None
BU1  A 242 (-3.6A)
None
None
 1.36A 3k8mB-1vioA:
undetectable		 3k8mB-1vioA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima) 		PF00258
(Flavodoxin_1) 		4 TYR A 190
GLU A  36
LEU A 191
TRP A 232
 None
 1.33A 3k8mB-1vmeA:
undetectable		 3k8mB-1vmeA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		4 TYR C 325
GLU C  69
LEU C 328
TRP C  80
 None
 1.40A 3k8mB-1vrnC:
undetectable		 3k8mB-1vrnC:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjz 1700030A21RIK
PROTEIN

(Mus musculus) 		PF00226
(DnaJ) 		4 TYR A  44
GLU A  60
LEU A  40
LYS A  39
 None
 1.35A 3k8mB-1wjzA:
undetectable		 3k8mB-1wjzA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH) 		4 TYR A  23
GLU A 114
LEU A  26
ASN A 130
 None
 1.34A 3k8mB-1wpnA:
undetectable		 3k8mB-1wpnA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		4 TYR B 265
GLU B 218
LEU B 266
ASN B 177
 None
 1.20A 3k8mB-1y8qB:
undetectable		 3k8mB-1y8qB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		4 GLU A 189
LEU A 209
TRP A 226
ASN A 211
 None
 1.15A 3k8mB-1yfjA:
undetectable		 3k8mB-1yfjA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		4 TYR A 166
GLU A 164
LEU A 169
ASN A 168
 None
 1.38A 3k8mB-1yfzA:
undetectable		 3k8mB-1yfzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		4 TRP A 238
LEU A 281
TRP A 293
LYS A 284
 None
 1.31A 3k8mB-2am4A:
undetectable		 3k8mB-2am4A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 TYR A 267
GLU A  55
LEU A 271
LYS A 223
 None
 1.43A 3k8mB-2cfmA:
undetectable		 3k8mB-2cfmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 4 TYR A 251
GLU A 156
TRP A 225
LEU A  97
 None
None
None
GOL  A 503 (-4.5A)
 1.16A 3k8mB-2de2A:
undetectable		 3k8mB-2de2A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2goj FE-SUPEROXIDE
DISMUTASE

(Plasmodium
falciparum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLU A  87
TRP A 184
LEU A 154
TRP A 178
 None
 1.37A 3k8mB-2gojA:
undetectable		 3k8mB-2gojA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j43 SPYDX

(Streptococcus
pyogenes) 		PF03714
(PUD) 		4 TRP A  40
LEU A  74
TRP A  30
ASN A  76
 None
 1.02A 3k8mB-2j43A:
3.2		 3k8mB-2j43A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j44 ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF03714
(PUD) 		4 TRP A  40
LEU A  74
TRP A  30
ASN A  76
 GLC  A1229 (-3.4A)
None
GLC  A1230 ( 3.7A)
None
 1.09A 3k8mB-2j44A:
2.2		 3k8mB-2j44A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j44 ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF03714
(PUD) 		5 TRP A 137
LEU A 178
TRP A 148
LYS A 188
ASN A 193
 GLC  A1228 (-3.8A)
None
GLC  A1227 (-3.7A)
GLC  A1227 (-2.5A)
GLC  A1228 (-2.7A)
 0.80A 3k8mB-2j44A:
2.2		 3k8mB-2j44A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 TYR A   3
GLU A  52
LEU A  56
ASN A  79
 None
 1.38A 3k8mB-2jg5A:
3.2		 3k8mB-2jg5A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lcj PAB POLC INTEIN

(Pyrococcus
abyssi) 		PF14890
(Intein_splicing) 		4 TYR A  50
LEU A   9
LYS A  18
ASN A 180
 None
 1.35A 3k8mB-2lcjA:
undetectable		 3k8mB-2lcjA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn5 HYPOTHETICAL PROTEIN
EF_2215

(Enterococcus
faecalis) 		PF08327
(AHSA1) 		4 TYR A  71
GLU A  48
LEU A  77
TRP A  28
 None
 1.26A 3k8mB-2nn5A:
undetectable		 3k8mB-2nn5A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		4 TYR A 259
GLU A 247
TRP A 270
LEU A 278
 None
 1.29A 3k8mB-2nvoA:
undetectable		 3k8mB-2nvoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 TYR A 218
GLU A 157
LEU A 219
ASN A  46
 None
 1.31A 3k8mB-2ocpA:
undetectable		 3k8mB-2ocpA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pei ORF134

(Synechococcus
sp. PCC 7002) 		PF02341
(RcbX) 		4 GLU A  43
TRP A  40
LEU A  67
ASN A  64
 None
 1.26A 3k8mB-2peiA:
undetectable		 3k8mB-2peiA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		4 TRP A 168
LEU A 202
TRP A 158
ASN A 204
 GLC  A2146 (-3.6A)
None
GLC  A2147 (-3.7A)
None
 1.05A 3k8mB-2ya1A:
0.0		 3k8mB-2ya1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		5 TRP A 265
LEU A 306
TRP A 276
LYS A 318
ASN A 323
 GLC  A2159 (-3.8A)
None
GLC  A2158 (-3.6A)
GLC  A2158 (-2.8A)
GLC  A2159 (-3.1A)
 0.64A 3k8mB-2ya1A:
0.0		 3k8mB-2ya1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yc2 SMALL RAB-RELATED
GTPASE

(Chlamydomonas
reinhardtii) 		PF00071
(Ras) 		4 GLU C 109
TRP C 155
LEU C 161
ASN C 159
 None
 1.37A 3k8mB-2yc2C:
undetectable		 3k8mB-2yc2C:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 TYR A 610
GLU A 590
LEU A 908
ASN A 862
 None
 1.31A 3k8mB-3aibA:
6.9		 3k8mB-3aibA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 GLU A  23
LEU A  30
LYS A  34
ASN A  49
 None
 1.10A 3k8mB-3al0A:
undetectable		 3k8mB-3al0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 TYR A 346
GLU A 266
LEU A 100
LYS A  84
 None
 1.29A 3k8mB-3fedA:
undetectable		 3k8mB-3fedA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLU A 214
TRP A 218
LEU A 497
ASN A 493
 None
 1.39A 3k8mB-3fw8A:
undetectable		 3k8mB-3fw8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE

(Salmonella
enterica) 		PF02614
(UxaC) 		4 TYR A  86
GLU A 126
TRP A 129
ASN A  49
 None
 1.41A 3k8mB-3iacA:
6.1		 3k8mB-3iacA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo sapiens) 		PF09817
(Zwilch) 		4 TYR B 432
GLU B 472
LEU B 428
LYS B 427
 None
 1.21A 3k8mB-3if8B:
undetectable		 3k8mB-3if8B:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 TYR A1203
GLU A 990
TRP A 989
LEU A1210
 None
 1.42A 3k8mB-3jb9A:
undetectable		 3k8mB-3jb9A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF05076
(SUFU) 		4 TYR A 124
GLU A  49
TRP A  15
LEU A 128
 None
 1.15A 3k8mB-3k5jA:
undetectable		 3k8mB-3k5jA:
13.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		7 TYR A 260
GLU A 263
TRP A 287
LEU A 290
TRP A 299
LYS A 304
ASN A 330
 None
None
EDO  A 909 ( 4.1A)
None
None
None
EDO  A 909 ( 4.2A)
 0.57A 3k8mB-3k8kA:
65.9		 3k8mB-3k8kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 4 TYR A 453
GLU A 447
LEU A 456
ASN A 441
 None
 1.36A 3k8mB-3ly9A:
undetectable		 3k8mB-3ly9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		4 TYR A 311
GLU A 386
LEU A 308
LYS A 307
 None
None
None
MG  A 397 ( 3.7A)
 1.28A 3k8mB-3nx3A:
undetectable		 3k8mB-3nx3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 TYR A 174
GLU A 134
TRP A 131
LEU A 178
 None
 1.04A 3k8mB-3op7A:
undetectable		 3k8mB-3op7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 GLU A 358
TRP A 359
LEU A 348
ASN A 349
 None
 1.31A 3k8mB-3pieA:
2.4		 3k8mB-3pieA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		4 TYR A 112
GLU A  79
LEU A 113
TRP A 101
 None
 1.40A 3k8mB-3pt1A:
undetectable		 3k8mB-3pt1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		4 TYR A 117
GLU A 222
LEU A 110
ASN A 226
 None
 1.31A 3k8mB-3q31A:
undetectable		 3k8mB-3q31A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		4 GLU B 339
LEU B 475
LYS B 509
ASN B 435
 None
 1.22A 3k8mB-3q75B:
undetectable		 3k8mB-3q75B:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A 509
GLU A 517
LEU A 506
TRP A 129
 None
 1.38A 3k8mB-3redA:
undetectable		 3k8mB-3redA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 TYR A 232
TRP A 339
LEU A 257
ASN A 343
 None
 1.40A 3k8mB-3sdqA:
undetectable		 3k8mB-3sdqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v 26S PROTEASOME
COMPLEX SUBUNIT SEM1
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05160
(DSS1_SEM1) 		4 TYR B 224
GLU C  30
LEU B 225
ASN B 184
 None
 1.34A 3k8mB-3t5vB:
undetectable		 3k8mB-3t5vB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA

(Pyrococcus
furiosus) 		PF09376
(NurA) 		4 TYR A 203
GLU A 159
LEU A 199
LYS A 198
 None
 0.81A 3k8mB-3talA:
undetectable		 3k8mB-3talA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcm ALANINE
AMINOTRANSFERASE 2

(Hordeum vulgare) 		PF00155
(Aminotran_1_2) 		4 TYR A 301
GLU A 304
LEU A 368
ASN A 264
 None
 1.33A 3k8mB-3tcmA:
undetectable		 3k8mB-3tcmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		4 TYR A 382
GLU A 450
TRP A 442
LEU A 379
 None
 1.26A 3k8mB-3u78A:
undetectable		 3k8mB-3u78A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 GLU A 485
LEU A 423
TRP A 456
ASN A 439
 None
 1.42A 3k8mB-3up4A:
undetectable		 3k8mB-3up4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2g 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 TYR A 180
LEU A 168
TRP A 120
ASN A 167
 None
 1.01A 3k8mB-3v2gA:
undetectable		 3k8mB-3v2gA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLU A 224
TRP A 228
LEU A 518
ASN A 514
 None
 1.39A 3k8mB-3vteA:
undetectable		 3k8mB-3vteA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		4 GLU A 222
LEU A 202
TRP A 183
ASN A 229
 None
 1.42A 3k8mB-3zizA:
9.4		 3k8mB-3zizA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 TYR A 240
GLU A 110
LEU A 239
ASN A 157
 None
 1.39A 3k8mB-3zuqA:
undetectable		 3k8mB-3zuqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE

(Vibrio cholerae) 		no annotation 4 TYR A 190
GLU A 197
TRP A 198
LEU A 203
 None
MG  A 301 ( 4.1A)
None
None
 1.39A 3k8mB-4evwA:
undetectable		 3k8mB-4evwA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exw SINGLE-STRANDED
DNA-BINDING PROTEIN
DDRB

(Deinococcus
geothermalis) 		PF12747
(DdrB) 		4 TYR A 103
GLU A  72
LEU A 128
TRP A  58
 None
 1.20A 3k8mB-4exwA:
undetectable		 3k8mB-4exwA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE

(Moorea
producens) 		PF13469
(Sulfotransfer_3) 		4 TYR A 305
TRP A 194
LEU A 303
ASN A 198
 None
None
P6G  A 417 (-4.9A)
None
 1.02A 3k8mB-4gbmA:
undetectable		 3k8mB-4gbmA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf2 ERYTHROCYTE BINDING
ANTIGEN 140

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 TYR A 504
GLU A 562
LEU A 508
TRP A 585
 None
 1.08A 3k8mB-4gf2A:
undetectable		 3k8mB-4gf2A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 4 TYR A 199
GLU A 219
LEU A 146
ASN A 161
 None
MN  A1003 ( 2.6A)
None
None
 1.42A 3k8mB-4gjiA:
5.1		 3k8mB-4gjiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 GLU A 203
TRP A 176
LYS A 114
ASN A 177
 None
 1.33A 3k8mB-4o5hA:
undetectable		 3k8mB-4o5hA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Brachybacterium
faecium) 		PF00156
(Pribosyltran) 		4 TYR A 191
GLU A 189
LEU A 194
ASN A 193
 None
 1.30A 3k8mB-4pfqA:
undetectable		 3k8mB-4pfqA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 TYR A 378
TRP A 284
LEU A 374
ASN A 386
 None
 1.37A 3k8mB-4q2cA:
undetectable		 3k8mB-4q2cA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		4 GLU A 287
LEU A 239
LYS A 272
ASN A 238
 FLC  A 402 (-3.8A)
None
None
None
 1.31A 3k8mB-4r9iA:
undetectable		 3k8mB-4r9iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x00 PUTATIVE HYDROLASE

(Burkholderia
cenocepacia) 		PF12697
(Abhydrolase_6) 		4 TYR A 135
GLU A 141
LEU A 222
ASN A 246
 None
 1.42A 3k8mB-4x00A:
undetectable		 3k8mB-4x00A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru RNL

(Capnocytophaga
gingivalis) 		PF16542
(PNKP_ligase) 		4 TYR B 324
GLU B 334
LEU B 320
ASN B 317
 None
None
None
GOL  B 503 (-3.7A)
 1.17A 3k8mB-4xruB:
undetectable		 3k8mB-4xruB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yet SUPEROXIDE DISMUTASE

(Babesia bovis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLU A  88
TRP A 185
LEU A 155
TRP A 179
 None
 1.37A 3k8mB-4yetA:
undetectable		 3k8mB-4yetA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 GLU A 381
LEU A 416
TRP A 429
ASN A 418
 None
 1.43A 3k8mB-5aeeA:
17.2		 3k8mB-5aeeA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Mus musculus) 		PF12777
(MT) 		4 GLU A3355
LEU A3398
LYS A3366
ASN A3399
 None
 1.42A 3k8mB-5ayhA:
undetectable		 3k8mB-5ayhA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 TYR A 212
GLU A 217
LEU A 209
ASN A 196
 None
 1.32A 3k8mB-5az0A:
8.1		 3k8mB-5az0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnd ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
epidermidis) 		no annotation 4 GLU A 498
TRP A 500
LEU A 401
TRP A 482
 None
 1.43A 3k8mB-5bndA:
undetectable		 3k8mB-5bndA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		4 TYR A 693
TRP A 578
LEU A  10
ASN A 581
 None
 1.37A 3k8mB-5bv9A:
undetectable		 3k8mB-5bv9A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLU A 222
TRP A 226
LEU A 507
ASN A 503
 None
 1.38A 3k8mB-5d79A:
undetectable		 3k8mB-5d79A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		4 TYR A 183
GLU A 227
LEU A 158
LYS A 180
 None
 1.42A 3k8mB-5dtrA:
undetectable		 3k8mB-5dtrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A 509
GLU A 517
LEU A 506
TRP A 129
 None
 1.40A 3k8mB-5eb5A:
undetectable		 3k8mB-5eb5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es2 UNCHARACTERIZED
PROTEIN LPG0634

(Legionella
pneumophila) 		PF16848
(SoDot-IcmSS) 		4 GLU A  62
LEU A  53
LYS A  16
ASN A  54
 None
 1.40A 3k8mB-5es2A:
undetectable		 3k8mB-5es2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 TYR A 122
GLU A 119
LEU A 133
ASN A 112
 None
None
None
LYS  A1319 (-3.1A)
 1.01A 3k8mB-5fxnA:
undetectable		 3k8mB-5fxnA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A 251
TRP A 306
LYS A 307
ASN A 247
 None
 1.23A 3k8mB-5g2vA:
undetectable		 3k8mB-5g2vA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 TRP A 400
LEU A 354
TRP A 310
ASN A 396
 None
None
PO4  A 802 (-3.9A)
None
 1.38A 3k8mB-5gslA:
12.6		 3k8mB-5gslA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 TRP A 398
LEU A 352
TRP A 308
ASN A 394
 None
GCS  A 801 (-4.9A)
GCS  A 801 ( 3.9A)
None
 1.37A 3k8mB-5gsmA:
12.3		 3k8mB-5gsmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A  93
GLU A 100
LEU A  90
TRP A 110
 None
 1.29A 3k8mB-5hesA:
undetectable		 3k8mB-5hesA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE EPSILON
CHAIN

(Caldalkalibacillus
thermarum) 		PF02823
(ATP-synt_DE_N) 		4 GLU H  86
LEU H 128
LYS H  94
ASN H 132
 None
 1.37A 3k8mB-5ik2H:
undetectable		 3k8mB-5ik2H:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Lymphocytic
choriomeningitis
mammarenavirus) 		PF00798
(Arena_glycoprot) 		4 TYR A 100
GLU A 236
TRP A 235
ASN A  90
 None
 1.38A 3k8mB-5ineA:
undetectable		 3k8mB-5ineA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 TYR B 766
GLU B 779
LEU B 759
ASN B 734
 None
 1.35A 3k8mB-5iz5B:
undetectable		 3k8mB-5iz5B:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 TYR A 185
GLU A 307
TRP A 286
LEU A 148
 None
 1.29A 3k8mB-5m8tA:
undetectable		 3k8mB-5m8tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5i HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RCDA

(Escherichia
coli) 		no annotation 4 GLU A  11
LEU A 105
LYS A  22
ASN A 102
 None
 1.34A 3k8mB-5x5iA:
undetectable		 3k8mB-5x5iA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		4 GLU A 904
LEU A 908
LYS A 913
ASN A 869
 None
 1.39A 3k8mB-5xblA:
undetectable		 3k8mB-5xblA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		4 GLU A 977
LEU A  52
LYS A1096
ASN A  14
 None
 1.42A 3k8mB-5xblA:
undetectable		 3k8mB-5xblA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpd SUGAR TRANSPORTER

(Arabidopsis
thaliana) 		PF00301
(Rubredoxin)
PF03083
(MtN3_slv) 		4 TYR A 235
GLU A 238
TRP A 259
LYS A 268
 None
 1.38A 3k8mB-5xpdA:
undetectable		 3k8mB-5xpdA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3p AMY13K

([Eubacterium]
rectale) 		no annotation 4 TYR A 297
TRP A 299
TRP A 314
ASN A 355
 GLC  A 405 (-3.2A)
GLC  A 406 ( 2.9A)
GLC  A 405 (-2.7A)
GLC  A 406 (-2.8A)
 0.78A 3k8mB-6b3pA:
3.5		 3k8mB-6b3pA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4) 		no annotation 4 GLU B  23
TRP B  31
LEU B  42
ASN B  35
 None
 1.40A 3k8mB-6c2jB:
undetectable		 3k8mB-6c2jB:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4

(Homo sapiens) 		no annotation 4 GLU A 890
LEU A1019
LYS A1022
ASN A 898
 None
 1.27A 3k8mB-6c90A:
undetectable		 3k8mB-6c90A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 GLU A 495
TRP A 492
LEU A 471
TRP A 406
 None
 1.18A 3k8mB-6eksA:
undetectable		 3k8mB-6eksA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN

(Azotobacter
vinelandii) 		no annotation 4 TYR A 272
GLU A 196
LEU A 268
ASN A 206
 None
 1.43A 3k8mB-6feaA:
undetectable		 3k8mB-6feaA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 GLU A1244
TRP A1245
LEU A1233
TRP A 996
 None
 0.94A 3k8mB-6fikA:
undetectable		 3k8mB-6fikA:
8.39