SIMILAR PATTERNS OF AMINO ACIDS FOR 3K8M_A_ACRA720_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8d DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF04423
(Rad50_zn_hook) 		4 TYR A 463
GLU A 458
LEU A 430
LYS A 426
 None
 1.41A 3k8mA-1l8dA:
undetectable		 3k8mA-1l8dA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6

(Saccharopolyspora
erythraea) 		PF00975
(Thioesterase) 		4 TYR A 149
TRP A 216
LEU A 146
TRP A 246
 None
 1.21A 3k8mA-1mo2A:
undetectable		 3k8mA-1mo2A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u53 SECRETED PROTEIN
ASP-2

(Necator
americanus) 		PF00188
(CAP) 		4 GLU A 137
TRP A 135
LEU A 118
ASN A 163
 None
 1.30A 3k8mA-1u53A:
undetectable		 3k8mA-1u53A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6l HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06983
(3-dmu-9_3-mt) 		4 TYR A  22
GLU A  17
LEU A  26
TRP A 131
 None
 1.40A 3k8mA-1u6lA:
undetectable		 3k8mA-1u6lA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		4 TYR A 253
GLU A 340
TRP A 337
LEU A 237
 None
 1.38A 3k8mA-1ujnA:
undetectable		 3k8mA-1ujnA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		4 TYR A1988
GLU A2114
TRP A2115
LEU A1950
 None
 1.24A 3k8mA-1uyvA:
undetectable		 3k8mA-1uyvA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vio RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A

(Haemophilus
influenzae) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		4 TYR A  62
GLU A  59
LEU A 222
TRP A 117
 None
BU1  A 242 (-3.6A)
None
None
 1.38A 3k8mA-1vioA:
undetectable		 3k8mA-1vioA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmw CHIMERIC CD3 MOUSE
EPSILON AND SHEEP
DELTA ECTODOMAIN
FRAGMENT COMPLEX

(Mus musculus;
Ovis aries) 		PF16680
(Ig_4)
PF16681
(Ig_5) 		4 TYR A  60
GLU A  37
TRP A  31
LEU A  19
 None
 1.16A 3k8mA-1xmwA:
undetectable		 3k8mA-1xmwA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		4 TYR B 265
GLU B 218
LEU B 266
ASN B 177
 None
 1.34A 3k8mA-1y8qB:
3.0		 3k8mA-1y8qB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 TYR 1 204
GLU 3 185
LEU 1 226
ASN 1 230
 None
 1.12A 3k8mA-1z7z1:
undetectable		 3k8mA-1z7z1:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		4 TRP A 238
LEU A 281
TRP A 293
LYS A 284
 None
 1.36A 3k8mA-2am4A:
undetectable		 3k8mA-2am4A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 TYR A 507
GLU A 529
TRP A 533
LEU A 635
 None
 1.41A 3k8mA-2d3tA:
2.0		 3k8mA-2d3tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 4 TYR A 251
GLU A 156
TRP A 225
LEU A  97
 None
None
None
GOL  A 503 (-4.5A)
 1.08A 3k8mA-2de2A:
undetectable		 3k8mA-2de2A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 GLU A 210
TRP A 183
LYS A 126
ASN A 184
 NAP  A1518 (-3.4A)
NAP  A1518 (-4.0A)
None
NAP  A1518 (-3.2A)
 1.35A 3k8mA-2ehqA:
undetectable		 3k8mA-2ehqA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6t UNCHARACTERIZED
PROTEIN, HOMOLOG
HI1244 FROM
HAEMOPHILUS
INFLUENZAE

(Clostridium
acetobutylicum) 		PF08942
(DUF1919) 		4 GLU A  85
LEU A  81
TRP A   7
LYS A  52
 None
 1.09A 3k8mA-2g6tA:
undetectable		 3k8mA-2g6tA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j43 SPYDX

(Streptococcus
pyogenes) 		PF03714
(PUD) 		4 TRP A  40
LEU A  74
TRP A  30
ASN A  76
 None
 1.03A 3k8mA-2j43A:
3.2		 3k8mA-2j43A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j44 ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF03714
(PUD) 		4 TRP A  40
LEU A  74
TRP A  30
ASN A  76
 GLC  A1229 (-3.4A)
None
GLC  A1230 ( 3.7A)
None
 1.10A 3k8mA-2j44A:
undetectable		 3k8mA-2j44A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j44 ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF03714
(PUD) 		5 TRP A 137
LEU A 178
TRP A 148
LYS A 188
ASN A 193
 GLC  A1228 (-3.8A)
None
GLC  A1227 (-3.7A)
GLC  A1227 (-2.5A)
GLC  A1228 (-2.7A)
 0.82A 3k8mA-2j44A:
undetectable		 3k8mA-2j44A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		4 TYR A 179
GLU A 116
LEU A 180
ASN A  28
 None
 1.19A 3k8mA-2jcsA:
undetectable		 3k8mA-2jcsA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjm PROTEIN NLRC5

(Mus musculus) 		no annotation 4 GLU A  16
TRP A  19
LEU A  62
TRP A  73
 None
 0.86A 3k8mA-2mjmA:
undetectable		 3k8mA-2mjmA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pei ORF134

(Synechococcus
sp. PCC 7002) 		PF02341
(RcbX) 		4 GLU A  43
TRP A  40
LEU A  67
ASN A  64
 None
 1.41A 3k8mA-2peiA:
undetectable		 3k8mA-2peiA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 TYR A  48
GLU A 144
LEU A  82
ASN A 114
 None
 1.42A 3k8mA-2vr5A:
20.2		 3k8mA-2vr5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLU B 433
TRP B 437
LEU B 444
ASN B 441
 None
 1.32A 3k8mA-2w55B:
undetectable		 3k8mA-2w55B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 TYR A 684
GLU A 706
LEU A 687
ASN A 637
 None
 1.06A 3k8mA-2wtbA:
undetectable		 3k8mA-2wtbA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		4 TRP A 168
LEU A 202
TRP A 158
ASN A 204
 GLC  A2146 (-3.6A)
None
GLC  A2147 (-3.7A)
None
 1.05A 3k8mA-2ya1A:
21.8		 3k8mA-2ya1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		5 TRP A 265
LEU A 306
TRP A 276
LYS A 318
ASN A 323
 GLC  A2159 (-3.8A)
None
GLC  A2158 (-3.6A)
GLC  A2158 (-2.8A)
GLC  A2159 (-3.1A)
 0.66A 3k8mA-2ya1A:
21.8		 3k8mA-2ya1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zme VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25

(Homo sapiens) 		PF05871
(ESCRT-II) 		4 GLU C   6
TRP C   7
LEU C  59
TRP C  33
 None
 1.43A 3k8mA-2zmeC:
undetectable		 3k8mA-2zmeC:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 GLU A  23
LEU A  30
LYS A  34
ASN A  49
 None
 0.92A 3k8mA-3al0A:
undetectable		 3k8mA-3al0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fib FIBRINOGEN GAMMA
CHAIN RESIDUES

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 TYR A 274
GLU A 213
TRP A 208
ASN A 317
 None
 1.13A 3k8mA-3fibA:
undetectable		 3k8mA-3fibA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		4 TRP A 174
TRP A 134
LYS A 160
ASN A 235
 None
 1.21A 3k8mA-3grhA:
undetectable		 3k8mA-3grhA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h20 REPLICATION PROTEIN
B

(Plasmid RSF1010) 		PF16793
(RepB_primase) 		4 GLU A  38
TRP A  39
LEU A  51
ASN A  47
 None
 1.42A 3k8mA-3h20A:
undetectable		 3k8mA-3h20A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu5 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 TYR A 144
GLU A  52
LEU A 145
ASN A 149
 None
 1.18A 3k8mA-3iu5A:
undetectable		 3k8mA-3iu5A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 TYR A1203
GLU A 990
TRP A 989
LEU A1210
 None
 1.40A 3k8mA-3jb9A:
undetectable		 3k8mA-3jb9A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3n PHD FINGER PROTEIN 8

(Homo sapiens) 		PF02373
(JmjC) 		4 TYR A 370
GLU A 222
TRP A 220
ASN A 363
 None
 1.29A 3k8mA-3k3nA:
undetectable		 3k8mA-3k3nA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		7 TYR A 260
GLU A 263
TRP A 287
LEU A 290
TRP A 299
LYS A 304
ASN A 330
 None
None
EDO  A 909 ( 4.1A)
None
None
None
EDO  A 909 ( 4.2A)
 0.31A 3k8mA-3k8kA:
66.4		 3k8mA-3k8kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE

(Homo sapiens) 		PF05577
(Peptidase_S28) 		4 TYR B 335
GLU B 348
TRP B 278
LEU B 331
 None
 1.28A 3k8mA-3n2zB:
undetectable		 3k8mA-3n2zB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnq N-TERMINAL DOMAIN OF
MOLONEY MURINE
LEUKEMIA VIRUS
INTEGRASE

(Murine leukemia
virus) 		PF16721
(zf-H3C2) 		4 TYR A  80
GLU A  73
LEU A  82
ASN A  83
 None
 1.27A 3k8mA-3nnqA:
undetectable		 3k8mA-3nnqA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415

(Drosophila
melanogaster) 		PF00106
(adh_short)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 TYR A 227
GLU A 231
LEU A 228
ASN A 193
 None
 1.16A 3k8mA-3omlA:
undetectable		 3k8mA-3omlA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 TYR A 201
GLU A 367
TRP A 366
LEU A 171
 None
 1.21A 3k8mA-3or2A:
undetectable		 3k8mA-3or2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 GLU A 358
TRP A 359
LEU A 348
ASN A 349
 None
 1.29A 3k8mA-3pieA:
3.2		 3k8mA-3pieA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 TYR A 147
GLU A 153
LEU A 252
ASN A 249
 None
 1.41A 3k8mA-3pzrA:
undetectable		 3k8mA-3pzrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		4 TYR A 117
GLU A 222
LEU A 110
ASN A 226
 None
 1.00A 3k8mA-3q31A:
undetectable		 3k8mA-3q31A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		4 GLU B 339
LEU B 475
LYS B 509
ASN B 435
 None
 1.16A 3k8mA-3q75B:
undetectable		 3k8mA-3q75B:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		4 TYR A  29
GLU A  20
LEU A  26
ASN A 492
 None
 1.42A 3k8mA-3qkiA:
undetectable		 3k8mA-3qkiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 TYR A 232
TRP A 339
LEU A 257
ASN A 343
 None
 1.38A 3k8mA-3sdqA:
undetectable		 3k8mA-3sdqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v 26S PROTEASOME
COMPLEX SUBUNIT SEM1
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05160
(DSS1_SEM1) 		4 TYR B 224
GLU C  30
LEU B 225
ASN B 184
 None
 1.14A 3k8mA-3t5vB:
undetectable		 3k8mA-3t5vB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		4 TYR A 382
GLU A 450
TRP A 442
LEU A 379
 None
 1.32A 3k8mA-3u78A:
undetectable		 3k8mA-3u78A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2g 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 TYR A 180
LEU A 168
TRP A 120
ASN A 167
 None
 1.03A 3k8mA-3v2gA:
2.9		 3k8mA-3v2gA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		4 TYR A 236
GLU A 275
LEU A 232
LYS A 231
 None
 1.42A 3k8mA-3wg6A:
4.5		 3k8mA-3wg6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 TYR A 150
GLU A 153
LEU A 570
ASN A 574
 None
None
None
SO4  A 808 (-3.9A)
 1.43A 3k8mA-3wnpA:
12.9		 3k8mA-3wnpA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 TYR A 240
GLU A 110
LEU A 239
ASN A 157
 None
 1.22A 3k8mA-3zuqA:
undetectable		 3k8mA-3zuqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bws THIOREDOXIN-LIKE
PROTEIN 4A

(Homo sapiens) 		PF02966
(DIM1) 		4 TYR A 136
GLU A 107
TRP A 104
LEU A  94
 None
 1.28A 3k8mA-4bwsA:
undetectable		 3k8mA-4bwsA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em2 UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349

(Staphylococcus
aureus) 		PF01047
(MarR) 		4 GLU A  64
LEU A 113
LYS A 133
ASN A 111
 None
 1.38A 3k8mA-4em2A:
undetectable		 3k8mA-4em2A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exw SINGLE-STRANDED
DNA-BINDING PROTEIN
DDRB

(Deinococcus
geothermalis) 		PF12747
(DdrB) 		4 TYR A 103
GLU A  72
LEU A 128
TRP A  58
 None
 1.28A 3k8mA-4exwA:
undetectable		 3k8mA-4exwA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		4 TYR A 355
GLU A 366
LYS A 351
ASN A 374
 None
 1.34A 3k8mA-4fxqA:
undetectable		 3k8mA-4fxqA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE

(Moorea
producens) 		PF13469
(Sulfotransfer_3) 		4 TYR A 305
TRP A 194
LEU A 303
ASN A 198
 None
None
P6G  A 417 (-4.9A)
None
 1.06A 3k8mA-4gbmA:
undetectable		 3k8mA-4gbmA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		4 TYR A 320
GLU A 324
LEU A 267
ASN A 251
 None
 1.32A 3k8mA-4gc5A:
undetectable		 3k8mA-4gc5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf2 ERYTHROCYTE BINDING
ANTIGEN 140

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 TYR A 504
GLU A 562
LEU A 508
TRP A 585
 None
 1.00A 3k8mA-4gf2A:
undetectable		 3k8mA-4gf2A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 GLU A 195
TRP A 168
LYS A 112
ASN A 169
 None
 1.36A 3k8mA-4kwgA:
undetectable		 3k8mA-4kwgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzg INTEGRASE P46

(Murine leukemia
virus) 		PF16721
(zf-H3C2) 		4 TYR A  80
GLU A  73
LEU A  82
ASN A  83
 None
 1.35A 3k8mA-4nzgA:
undetectable		 3k8mA-4nzgA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 GLU A 203
TRP A 176
LYS A 114
ASN A 177
 None
 1.33A 3k8mA-4o5hA:
2.0		 3k8mA-4o5hA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py5 RIBONUCLEASE

(Thermovibrio
ammonificans) 		PF01351
(RNase_HII) 		4 GLU A 187
LEU A 157
LYS A  82
ASN A 154
 None
None
C  B   6 ( 2.8A)
SO4  A 306 (-3.8A)
 1.20A 3k8mA-4py5A:
undetectable		 3k8mA-4py5A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 TYR A 378
TRP A 284
LEU A 374
ASN A 386
 None
 1.34A 3k8mA-4q2cA:
undetectable		 3k8mA-4q2cA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 GLU A 343
LEU A 352
LYS A 389
ASN A 349
 None
 1.43A 3k8mA-4qeiA:
undetectable		 3k8mA-4qeiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		4 GLU A 287
LEU A 239
LYS A 272
ASN A 238
 FLC  A 402 (-3.8A)
None
None
None
 1.26A 3k8mA-4r9iA:
undetectable		 3k8mA-4r9iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 TYR A 774
GLU A 121
LEU A 775
ASN A 460
 None
 1.19A 3k8mA-4rbnA:
undetectable		 3k8mA-4rbnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfs SUBSTRATE BINDING
PRITEIN S

(Lactobacillus
brevis) 		PF12822
(ECF_trnsprt) 		4 TYR S 106
GLU S 195
TRP S 194
LEU S 107
 None
 1.41A 3k8mA-4rfsS:
undetectable		 3k8mA-4rfsS:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 TYR A 360
GLU A 375
LEU A 370
ASN A 383
 None
 1.30A 3k8mA-4xgtA:
undetectable		 3k8mA-4xgtA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 TYR A  55
GLU A 379
LEU A  56
ASN A  60
 None
 1.03A 3k8mA-4xnuA:
undetectable		 3k8mA-4xnuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 GLU A1089
LEU A1079
TRP A1075
ASN A 239
 None
 1.42A 3k8mA-5amqA:
2.9		 3k8mA-5amqA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 TYR A 212
GLU A 217
LEU A 209
ASN A 196
 None
 1.41A 3k8mA-5az0A:
8.3		 3k8mA-5az0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnd ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
epidermidis) 		no annotation 4 GLU A 498
TRP A 500
LEU A 401
TRP A 482
 None
 1.32A 3k8mA-5bndA:
undetectable		 3k8mA-5bndA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TYR A 363
GLU A 254
LEU A 323
ASN A 321
 None
 1.33A 3k8mA-5brqA:
32.4		 3k8mA-5brqA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 TYR B 362
GLU B 254
LEU B 322
ASN B 320
 None
BGC  B 601 ( 2.7A)
None
None
 1.33A 3k8mA-5do8B:
32.1		 3k8mA-5do8B:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewo STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		4 TYR A 519
GLU A 498
TRP A 489
LEU A 540
 None
 1.35A 3k8mA-5ewoA:
undetectable		 3k8mA-5ewoA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpw PRO CATHEPSIN B S9

(Trypanosoma
congolense) 		PF00112
(Peptidase_C1) 		4 TYR A 274
GLU A  73
LEU A 269
ASN A 270
 None
 1.42A 3k8mA-5fpwA:
undetectable		 3k8mA-5fpwA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 TYR A 122
GLU A 119
LEU A 133
ASN A 112
 None
None
None
LYS  A1319 (-3.1A)
 1.23A 3k8mA-5fxnA:
undetectable		 3k8mA-5fxnA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 REPEBODY

(Escherichia
coli) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 TYR B  61
GLU B  83
LEU B  40
ASN B  41
 None
 1.41A 3k8mA-5gs2B:
undetectable		 3k8mA-5gs2B:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 TRP A 400
LEU A 354
TRP A 310
ASN A 396
 None
None
PO4  A 802 (-3.9A)
None
 1.39A 3k8mA-5gslA:
12.6		 3k8mA-5gslA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 TRP A 398
LEU A 352
TRP A 308
ASN A 394
 None
GCS  A 801 (-4.9A)
GCS  A 801 ( 3.9A)
None
 1.38A 3k8mA-5gsmA:
12.7		 3k8mA-5gsmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A  93
GLU A 100
LEU A  90
TRP A 110
 None
 1.24A 3k8mA-5hesA:
undetectable		 3k8mA-5hesA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		4 TYR A 213
GLU A 219
LEU A 223
LYS A 180
 None
 1.34A 3k8mA-5hjlA:
7.2		 3k8mA-5hjlA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE EPSILON
CHAIN

(Caldalkalibacillus
thermarum) 		PF02823
(ATP-synt_DE_N) 		4 GLU H  86
LEU H 128
LYS H  94
ASN H 132
 None
 1.40A 3k8mA-5ik2H:
undetectable		 3k8mA-5ik2H:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Lymphocytic
choriomeningitis
mammarenavirus) 		PF00798
(Arena_glycoprot) 		4 TYR A 100
GLU A 236
TRP A 235
ASN A  90
 None
 1.35A 3k8mA-5ineA:
undetectable		 3k8mA-5ineA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp6 PUTATIVE
POLYSACCHARIDE
DEACETYLASE

(Bdellovibrio
bacteriovorus) 		PF01522
(Polysacc_deac_1) 		4 GLU A  47
TRP A  46
LEU A  92
ASN A  37
 PXU  A 279 ( 4.2A)
None
None
None
 1.30A 3k8mA-5jp6A:
2.2		 3k8mA-5jp6A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwy EPIDIDYMAL SECRETORY
PROTEIN E1

(Homo sapiens) 		PF02221
(E1_DerP2_DerF2) 		4 GLU C 127
TRP C 128
LEU C 113
ASN C 111
 None
None
C3S  C 203 ( 4.5A)
None
 1.14A 3k8mA-5kwyC:
undetectable		 3k8mA-5kwyC:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 4 TYR A 314
GLU A 309
LYS A 336
ASN A 331
 None
 1.22A 3k8mA-5n4cA:
undetectable		 3k8mA-5n4cA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 GLU A 798
TRP A 799
LEU A 826
ASN A 644
 None
 1.38A 3k8mA-5o1pA:
2.3		 3k8mA-5o1pA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suj UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A 173
GLU A 158
LEU A 168
ASN A 152
 None
 1.41A 3k8mA-5sujA:
undetectable		 3k8mA-5sujA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnu DNA-DEPENDENT ATPASE
XPBII

(Sulfurisphaera
tokodaii) 		no annotation 4 TYR A 195
GLU A  83
TRP A  80
LEU A 170
 None
GOL  A 518 (-4.6A)
None
None
 1.42A 3k8mA-5tnuA:
undetectable		 3k8mA-5tnuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		4 TYR B1013
GLU B1016
TRP B1037
LYS B1046
 None
 1.41A 3k8mA-5vblB:
undetectable		 3k8mA-5vblB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgs LACHRYMATORY-FACTOR
SYNTHASE

(Allium cepa) 		PF10604
(Polyketide_cyc2) 		4 TYR A 100
TRP A  38
LEU A  93
ASN A  95
 None
 1.28A 3k8mA-5vgsA:
undetectable		 3k8mA-5vgsA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5i HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RCDA

(Escherichia
coli) 		no annotation 4 GLU A  11
LEU A 105
LYS A  22
ASN A 102
 None
 1.23A 3k8mA-5x5iA:
undetectable		 3k8mA-5x5iA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 TYR A  82
GLU A 265
TRP A 266
ASN A  74
 None
 1.37A 3k8mA-5xjjA:
undetectable		 3k8mA-5xjjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		4 TYR w 233
GLU w 171
LEU w 234
ASN w  65
 None
 1.40A 3k8mA-5xtdw:
undetectable		 3k8mA-5xtdw:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydy WW2 DOMAIN AND PPXY
MOTIF COMPLEX

(Homo sapiens) 		no annotation 4 TYR A  27
GLU A  16
TRP A  15
LEU A  38
 None
 1.11A 3k8mA-5ydyA:
undetectable		 3k8mA-5ydyA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3p AMY13K

([Eubacterium]
rectale) 		no annotation 4 TYR A 297
TRP A 299
TRP A 314
ASN A 355
 GLC  A 405 (-3.2A)
GLC  A 406 ( 2.9A)
GLC  A 405 (-2.7A)
GLC  A 406 (-2.8A)
 0.76A 3k8mA-6b3pA:
2.7		 3k8mA-6b3pA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4) 		no annotation 4 GLU B  23
TRP B  31
LEU B  42
ASN B  35
 None
 1.10A 3k8mA-6c2jB:
undetectable		 3k8mA-6c2jB:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 GLU A1244
TRP A1245
LEU A1233
TRP A 996
 None
 1.00A 3k8mA-6fikA:
undetectable		 3k8mA-6fikA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 TYR O 198
GLU O 136
LEU O 199
ASN O  30
 None
 1.19A 3k8mA-6g2jO:
undetectable		 3k8mA-6g2jO:
8.67