SIMILAR PATTERNS OF AMINO ACIDS FOR 3K5V_A_STIA2_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		4 LEU A 391
VAL A 345
VAL A 341
ILE A 402
 None
 1.16A 3k5vA-1cg4A:
undetectable		 3k5vA-1cg4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 248
LYS A 251
VAL A  58
MET A  95
 None
 0.97A 3k5vA-1iovA:
undetectable		 3k5vA-1iovA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsd HAEMAGGLUTININ (HA1
CHAIN)

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 144
VAL A 226
VAL A 194
ILE A 116
 None
 1.08A 3k5vA-1jsdA:
undetectable		 3k5vA-1jsdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Haemophilus
influenzae) 		PF08282
(Hydrolase_3) 		4 LEU A 156
VAL A  15
VAL A  54
ILE A 105
 None
 1.20A 3k5vA-1k1eA:
undetectable		 3k5vA-1k1eA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.59A 3k5vA-1k9aA:
31.1		 3k5vA-1k9aA:
30.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		4 LEU A 580
VAL A 411
VAL A 309
ILE A 574
 None
 1.08A 3k5vA-1morA:
undetectable		 3k5vA-1morA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  70
LYS A  93
VAL A 118
ILE A 136
 STU  A 401 (-3.9A)
STU  A 401 ( 4.5A)
None
None
 0.48A 3k5vA-1nxkA:
19.2		 3k5vA-1nxkA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
LYS A 290
VAL A 308
VAL A 318
ILE A 332
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
 0.52A 3k5vA-1opkA:
37.0		 3k5vA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 267
VAL A 308
ILE A 332
MET A 337
 P16  A   2 ( 4.2A)
None
P16  A   2 (-4.1A)
None
 0.45A 3k5vA-1opkA:
37.0		 3k5vA-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE

(Thermotoga
maritima) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A  33
VAL A 191
VAL A 198
ILE A   9
 None
 1.19A 3k5vA-1pw5A:
undetectable		 3k5vA-1pw5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryo SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 LEU A 134
VAL A  67
VAL A 246
ILE A 323
 None
 1.14A 3k5vA-1ryoA:
undetectable		 3k5vA-1ryoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		4 LEU A 122
VAL A  19
VAL A  15
ILE A  87
 None
 1.03A 3k5vA-1srdA:
undetectable		 3k5vA-1srdA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		4 LEU A 454
VAL A 494
ILE A 517
MET A 117
 None
 1.20A 3k5vA-1w18A:
undetectable		 3k5vA-1w18A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.02A 3k5vA-1ycnA:
undetectable		 3k5vA-1ycnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 LEU A 217
VAL A  38
VAL A 238
ILE A 176
 None
 1.04A 3k5vA-2a30A:
undetectable		 3k5vA-2a30A:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
LYS X  39
VAL X  67
ILE X  80
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
None
 0.57A 3k5vA-2dq7X:
31.7		 3k5vA-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
LYS A 186
VAL A 204
ILE A 234
 None
 0.58A 3k5vA-2eu9A:
21.2		 3k5vA-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
VAL A 204
VAL A 220
ILE A 234
 None
 0.42A 3k5vA-2eu9A:
21.2		 3k5vA-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.78A 3k5vA-2h8hA:
29.7		 3k5vA-2h8hA:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
None
 0.86A 3k5vA-2hckA:
29.4		 3k5vA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.61A 3k5vA-2hk5A:
31.7		 3k5vA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.76A 3k5vA-2hk5A:
31.7		 3k5vA-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 248
LYS A 271
VAL A 289
ILE A 313
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.8A)
 0.69A 3k5vA-2hz0A:
34.4		 3k5vA-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 289
VAL A 299
ILE A 313
MET A 318
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
 0.42A 3k5vA-2hz0A:
34.4		 3k5vA-2hz0A:
97.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A  73
VAL A 121
VAL A 114
ILE A 105
 None
 1.02A 3k5vA-2i80A:
undetectable		 3k5vA-2i80A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU B 181
VAL B 246
ILE B 201
MET B 195
 None
 1.22A 3k5vA-2ippB:
undetectable		 3k5vA-2ippB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.14A 3k5vA-2iyoA:
undetectable		 3k5vA-2iyoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnl C-X-C CHEMOKINE
RECEPTOR TYPE 1

(Homo sapiens) 		PF00001
(7tm_1) 		4 LEU A  37
VAL A 261
VAL A 272
ILE A 283
 None
 0.77A 3k5vA-2lnlA:
undetectable		 3k5vA-2lnlA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 LEU A 412
VAL A 372
VAL A 376
ILE A 207
 None
 1.06A 3k5vA-2mbgA:
undetectable		 3k5vA-2mbgA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 301
ILE A 314
MET A 319
 None
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
 0.60A 3k5vA-2og8A:
31.6		 3k5vA-2og8A:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU X  70
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
 0.77A 3k5vA-2p3gX:
17.6		 3k5vA-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1

(Mus musculus) 		PF00651
(BTB) 		4 LEU A  98
VAL A  51
VAL A 115
ILE A  88
 None
 1.11A 3k5vA-2z8hA:
undetectable		 3k5vA-2z8hA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 253
LYS A 275
VAL A 303
ILE A 317
 None
 0.83A 3k5vA-2zv7A:
25.3		 3k5vA-2zv7A:
46.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		4 LEU A  60
VAL A  47
VAL A  72
ILE A  16
 None
 1.03A 3k5vA-3d0cA:
undetectable		 3k5vA-3d0cA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.59A 3k5vA-3d7uA:
31.7		 3k5vA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.61A 3k5vA-3dkoA:
30.5		 3k5vA-3dkoA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A  94
VAL A  61
VAL A  76
ILE A  64
 None
 1.02A 3k5vA-3e82A:
undetectable		 3k5vA-3e82A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.55A 3k5vA-3fmeA:
21.3		 3k5vA-3fmeA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
VAL A 113
ILE A 127
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.57A 3k5vA-3fmeA:
21.3		 3k5vA-3fmeA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9m CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU A 181
VAL A 246
ILE A 201
MET A 195
 None
 1.18A 3k5vA-3k9mA:
undetectable		 3k5vA-3k9mA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE

(Staphylococcus
saprophyticus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A 127
VAL A 163
VAL A 158
ILE A 137
 None
 1.07A 3k5vA-3l8mA:
undetectable		 3k5vA-3l8mA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 LEU A 375
LYS A 368
ILE A 245
MET A 254
 None
 1.10A 3k5vA-3maxA:
undetectable		 3k5vA-3maxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 246
VAL A 362
VAL A 268
ILE A 325
 None
 1.04A 3k5vA-3mruA:
undetectable		 3k5vA-3mruA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 183
VAL A 104
VAL A  96
ILE A 161
 None
 1.06A 3k5vA-3o76A:
undetectable		 3k5vA-3o76A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1x SERINE
ACETYLTRANSFERASE

(Entamoeba
histolytica) 		PF00132
(Hexapep) 		4 LEU A 103
VAL A 185
VAL A 158
ILE A 178
 None
 1.19A 3k5vA-3q1xA:
undetectable		 3k5vA-3q1xA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtd PMBA PROTEIN

(Pseudomonas
aeruginosa) 		PF01523
(PmbA_TldD) 		4 LEU A 300
VAL A 424
VAL A 253
ILE A 428
 None
 1.00A 3k5vA-3qtdA:
undetectable		 3k5vA-3qtdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 104
VAL A 305
VAL A 301
ILE A 331
 None
 0.77A 3k5vA-3ramA:
undetectable		 3k5vA-3ramA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  50
LYS A  73
VAL A  98
ILE A 116
 I85  A 350 (-3.7A)
I85  A 350 (-2.8A)
None
None
 0.69A 3k5vA-3sheA:
18.5		 3k5vA-3sheA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 LEU A 111
VAL A 134
VAL A 126
ILE A 150
 None
 1.07A 3k5vA-3u02A:
undetectable		 3k5vA-3u02A:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 544
LYS A 572
VAL A 601
MET A 620
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.0A)
None
None
 0.82A 3k5vA-3v5qA:
32.4		 3k5vA-3v5qA:
36.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 LEU A 427
VAL A 467
ILE A 494
MET A  93
 None
 1.11A 3k5vA-3vssA:
undetectable		 3k5vA-3vssA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  75
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.61A 3k5vA-3wigA:
21.6		 3k5vA-3wigA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)

(Trypanosoma
brucei) 		PF00025
(Arf) 		4 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 0.92A 3k5vA-4basA:
undetectable		 3k5vA-4basA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwi PHYTOCHROME-LIKE
PROTEIN CPH2

(Synechocystis
sp.) 		PF00360
(PHY)
PF01590
(GAF) 		4 LEU A 153
VAL A  30
ILE A  46
MET A  94
 GLU  A1427 ( 4.9A)
None
None
None
 1.16A 3k5vA-4bwiA:
undetectable		 3k5vA-4bwiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 LEU A  88
VAL A 445
VAL A 405
ILE A 415
 None
 1.15A 3k5vA-4ckbA:
undetectable		 3k5vA-4ckbA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz2 RAS-RELATED PROTEIN
RAB-32

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A  67
VAL A  60
VAL A  28
ILE A  42
 None
 1.18A 3k5vA-4cz2A:
undetectable		 3k5vA-4cz2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 LEU A  80
VAL A 259
VAL A 205
ILE A  48
 None
 1.15A 3k5vA-4d1tA:
undetectable		 3k5vA-4d1tA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei0 UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF14725
(DUF4466) 		4 LEU A 190
VAL A 324
VAL A 328
ILE A 198
 None
 1.20A 3k5vA-4ei0A:
undetectable		 3k5vA-4ei0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.7A)
BX7  A 401 ( 4.0A)
None
None
 0.71A 3k5vA-4eutA:
19.0		 3k5vA-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.5A)
None
None
 0.70A 3k5vA-4euuA:
15.5		 3k5vA-4euuA:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 377
LYS A 402
VAL A 423
VAL A 433
 0SB  A 701 ( 3.9A)
0SB  A 701 ( 4.8A)
None
None
 0.75A 3k5vA-4f4pA:
29.3		 3k5vA-4f4pA:
40.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 650
VAL A 636
VAL A 741
ILE A 642
 LEU  A 650 ( 0.6A)
VAL  A 636 ( 0.5A)
VAL  A 741 ( 0.5A)
ILE  A 642 ( 0.6A)
 0.82A 3k5vA-4flxA:
undetectable		 3k5vA-4flxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 598
LYS A 621
VAL A 651
ILE A 885
 924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
 0.50A 3k5vA-4g34A:
16.5		 3k5vA-4g34A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 422
VAL A 366
VAL A 453
ILE A 416
 None
C  D   8 ( 3.9A)
None
G  D   9 ( 4.4A)
 1.18A 3k5vA-4gl2A:
undetectable		 3k5vA-4gl2A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2) 		4 LEU C 485
VAL C 473
VAL C 477
ILE C 600
 None
 0.92A 3k5vA-4gnxC:
undetectable		 3k5vA-4gnxC:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		4 LEU A 169
VAL A 294
VAL A 238
ILE A 192
 None
 0.88A 3k5vA-4hjwA:
undetectable		 3k5vA-4hjwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 634
VAL A 539
VAL A 516
MET A 585
 None
 1.23A 3k5vA-4idtA:
21.5		 3k5vA-4idtA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
 0.58A 3k5vA-4k11A:
29.8		 3k5vA-4k11A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.73A 3k5vA-4lggA:
29.8		 3k5vA-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 313
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 (-4.2A)
None
 0.91A 3k5vA-4lggA:
29.8		 3k5vA-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.60A 3k5vA-4lggA:
29.8		 3k5vA-4lggA:
45.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 LEU A 674
VAL A 620
VAL A 608
MET A 644
 SO4  A 802 ( 4.9A)
None
None
None
 1.12A 3k5vA-4ot9A:
undetectable		 3k5vA-4ot9A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 LEU A  70
VAL A 163
VAL A 188
ILE A 183
 None
 1.20A 3k5vA-4r5zA:
undetectable		 3k5vA-4r5zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1

(Homo sapiens) 		PF05609
(LAP1C) 		4 LEU A 536
VAL A 506
VAL A 478
ILE A 409
 None
 1.14A 3k5vA-4tvsA:
undetectable		 3k5vA-4tvsA:
23.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
LYS A  37
VAL A  65
ILE A  79
 ACP  A1264 ( 4.5A)
None
None
None
 0.71A 3k5vA-4ueuA:
22.5		 3k5vA-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
VAL A  65
ILE A  79
MET A  84
 ACP  A1264 ( 4.5A)
None
None
None
 0.65A 3k5vA-4ueuA:
22.5		 3k5vA-4ueuA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0k ARF-LIKE SMALL
GTPASE

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		4 LEU A 163
VAL A  20
VAL A  93
ILE A  34
 GDP  A 700 (-4.4A)
None
None
None
 0.87A 3k5vA-4v0kA:
undetectable		 3k5vA-4v0kA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.0A)
None
None
None
 0.68A 3k5vA-4wsqA:
22.2		 3k5vA-4wsqA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LEU B 267
LYS B 290
VAL B 318
ILE B 332
 1N1  B 601 (-3.7A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
 0.82A 3k5vA-4xeyB:
34.2		 3k5vA-4xeyB:
71.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 LEU A 242
VAL A 274
VAL A 284
ILE A 259
 None
 1.20A 3k5vA-4xyiA:
undetectable		 3k5vA-4xyiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 LEU A  92
VAL A  12
VAL A 109
ILE A 128
 None
 1.19A 3k5vA-4zhtA:
undetectable		 3k5vA-4zhtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a87 METALLO-BETA-LACTAMA
SE VIM-5

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		4 LEU A  80
VAL A 236
VAL A 188
ILE A  49
 None
 1.22A 3k5vA-5a87A:
undetectable		 3k5vA-5a87A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE

(Micromonospora
griseorubida) 		PF00067
(p450) 		4 LEU A 361
VAL A 142
VAL A 236
ILE A 117
 None
 0.95A 3k5vA-5foiA:
undetectable		 3k5vA-5foiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		4 LEU A 104
VAL A 338
VAL A 193
ILE A  62
 None
 1.14A 3k5vA-5hgcA:
undetectable		 3k5vA-5hgcA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 LEU A 184
VAL A 272
VAL A 238
ILE A 117
 None
 1.07A 3k5vA-5hp5A:
undetectable		 3k5vA-5hp5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  57
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-3.8A)
IDV  A 401 ( 4.8A)
None
None
 0.44A 3k5vA-5i3oA:
22.0		 3k5vA-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 322
VAL A 402
ILE A 433
MET A 306
 None
 1.06A 3k5vA-5jcfA:
undetectable		 3k5vA-5jcfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A 981
VAL A 957
VAL A 913
ILE A 427
 None
 1.15A 3k5vA-5m5pA:
undetectable		 3k5vA-5m5pA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA

(Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 VAL B  79
VAL B  48
ILE B 142
MET B 131
 None
 1.21A 3k5vA-5n1qB:
undetectable		 3k5vA-5n1qB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  17
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.69A 3k5vA-5u94A:
18.5		 3k5vA-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Burkholderia
ambifaria) 		PF12697
(Abhydrolase_6) 		4 LEU A 227
VAL A 264
VAL A 252
ILE A 243
 None
 1.12A 3k5vA-5w15A:
undetectable		 3k5vA-5w15A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		no annotation 4 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.11A 3k5vA-5zzkA:
undetectable		 3k5vA-5zzkA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT

(Pyrococcus
furiosus) 		no annotation 4 LEU M 315
VAL M 276
VAL M 248
MET M 152
 None
 1.18A 3k5vA-6cfwM:
undetectable		 3k5vA-6cfwM:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 869
VAL A 558
ILE A 883
MET A 921
 None
 1.23A 3k5vA-6eojA:
undetectable		 3k5vA-6eojA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 LEU A 169
LYS A 193
VAL A 211
ILE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.0A)
None
None
 0.54A 3k5vA-6fylA:
21.4		 3k5vA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 LEU A 169
VAL A 211
VAL A 227
ILE A 241
 3NG  A 501 (-3.9A)
None
None
None
 0.67A 3k5vA-6fylA:
21.4		 3k5vA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.64A 3k5vA-6fyoA:
21.1		 3k5vA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
None
None
 0.74A 3k5vA-6fyoA:
21.1		 3k5vA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.60A 3k5vA-6fyvA:
15.9		 3k5vA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 3NG  A 501 (-3.9A)
None
None
None
 0.68A 3k5vA-6fyvA:
15.9		 3k5vA-6fyvA:
undetectable