SIMILAR PATTERNS OF AMINO ACIDS FOR 3K54_A_1N1A1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 428
LYS A 430
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 None
 0.64A 3k54A-1k2pA:
29.4		 3k54A-1k2pA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.60A 3k54A-1k9aA:
31.8		 3k54A-1k9aA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
SER A 331
 None
 0.68A 3k54A-1k9aA:
31.8		 3k54A-1k9aA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.79A 3k54A-1opkA:
30.3		 3k54A-1opkA:
29.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 389
LYS A 391
MET A 410
VAL A 419
GLY A 441
LEU A 489
SER A 499
 None
 0.74A 3k54A-1snxA:
24.4		 3k54A-1snxA:
53.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 595
ALA A 621
LYS A 623
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.82A 3k54A-1t46A:
30.5		 3k54A-1t46A:
34.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
SER A 478
 STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
 0.70A 3k54A-1u59A:
24.8		 3k54A-1u59A:
34.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  36
LYS A  38
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
SER A 147
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.72A 3k54A-1zltA:
21.3		 3k54A-1zltA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
ALA A  36
LYS A  38
GLU A  55
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.71A 3k54A-1zltA:
21.3		 3k54A-1zltA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU X  17
ALA X  37
GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
TYR X  84
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.64A 3k54A-2dq7X:
31.5		 3k54A-2dq7X:
38.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
ALA X  37
LYS X  39
GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.4A)
 0.73A 3k54A-2dq7X:
31.5		 3k54A-2dq7X:
38.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.53A 3k54A-2h8hA:
30.2		 3k54A-2h8hA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.78A 3k54A-2hckA:
30.3		 3k54A-2hckA:
28.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 659
LYS A 661
GLU A 678
MET A 682
ILE A 705
THR A 707
LEU A 761
SER A 771
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.80A 3k54A-2henA:
32.6		 3k54A-2henA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 659
LYS A 661
MET A 682
ILE A 705
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.74A 3k54A-2henA:
32.6		 3k54A-2henA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.51A 3k54A-2hk5A:
32.3		 3k54A-2hk5A:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
ALA A 269
LYS A 271
GLU A 286
MET A 290
VAL A 299
ILE A 313
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 0.80A 3k54A-2hz0A:
30.5		 3k54A-2hz0A:
44.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
GLU A 471
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.72A 3k54A-2j0jA:
32.1		 3k54A-2j0jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.72A 3k54A-2j0jA:
32.1		 3k54A-2j0jA:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.64A 3k54A-2jkmA:
23.2		 3k54A-2jkmA:
36.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
TYR A 318
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.76A 3k54A-2og8A:
31.4		 3k54A-2og8A:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 588
ALA A 614
LYS A 616
GLU A 633
MET A 637
VAL A 647
THR A 663
TYR A 665
GLY A 669
LEU A 785
 None
 0.83A 3k54A-2ogvA:
20.3		 3k54A-2ogvA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 None
 0.88A 3k54A-2psqA:
31.6		 3k54A-2psqA:
32.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 0.86A 3k54A-2qobA:
27.6		 3k54A-2qobA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 0.77A 3k54A-2qobA:
27.6		 3k54A-2qobA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.61A 3k54A-2r2pA:
31.9		 3k54A-2r2pA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ALA A 705
LYS A 707
GLU A 724
MET A 728
ILE A 751
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.75A 3k54A-2r2pA:
31.9		 3k54A-2r2pA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
 0.68A 3k54A-2xyuA:
33.3		 3k54A-2xyuA:
37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 651
MET A 674
ILE A 697
THR A 699
TYR A 701
GLY A 705
LEU A 753
SER A 763
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
 0.54A 3k54A-2xyuA:
33.3		 3k54A-2xyuA:
37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
ALA A1028
LYS A1030
GLU A1047
MET A1051
VAL A1060
GLY A1082
 S91  A   1 ( 4.1A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
None
S91  A   1 (-3.3A)
 0.66A 3k54A-2z8cA:
29.4		 3k54A-2z8cA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 LEU A 253
ALA A 273
LYS A 275
GLU A 290
MET A 294
VAL A 303
ILE A 317
THR A 319
GLY A 325
LEU A 374
 None
 0.61A 3k54A-2zv7A:
15.1		 3k54A-2zv7A:
40.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.77A 3k54A-3b2tA:
31.4		 3k54A-3b2tA:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.60A 3k54A-3d7uA:
27.8		 3k54A-3d7uA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
SER A 331
 None
 0.68A 3k54A-3d7uA:
27.8		 3k54A-3d7uA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 663
GLU A 682
MET A 686
VAL A 695
ILE A 709
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.81A 3k54A-3dkoA:
31.5		 3k54A-3dkoA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.76A 3k54A-3dkoA:
31.5		 3k54A-3dkoA:
36.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.72A 3k54A-3g2fA:
25.2		 3k54A-3g2fA:
27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
ALA A 859
LYS A 861
GLU A 878
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.80A 3k54A-3hngA:
29.7		 3k54A-3hngA:
32.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 696
LYS A 723
VAL A 753
THR A 768
TYR A 770
GLY A 774
LEU A 822
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 (-4.3A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
 0.50A 3k54A-3kexA:
27.7		 3k54A-3kexA:
28.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.66A 3k54A-3kulA:
32.5		 3k54A-3kulA:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.87A 3k54A-3kulA:
32.5		 3k54A-3kulA:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.83A 3k54A-3kulA:
32.5		 3k54A-3kulA:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.53A 3k54A-3kulA:
32.5		 3k54A-3kulA:
36.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.67A 3k54A-3my0A:
25.6		 3k54A-3my0A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  88
ALA A 109
LYS A 111
GLU A 130
MET A 134
TYR A 161
GLY A 165
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
None
None
 0.79A 3k54A-3nuuA:
23.5		 3k54A-3nuuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.65A 3k54A-3nyoA:
22.1		 3k54A-3nyoA:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		9 ALA A 576
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.70A 3k54A-3ppzA:
29.5		 3k54A-3ppzA:
30.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		9 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.78A 3k54A-3ppzA:
29.5		 3k54A-3ppzA:
30.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 423
ALA A 443
LYS A 445
VAL A 473
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.75A 3k54A-3sxsA:
33.2		 3k54A-3sxsA:
62.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 423
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.62A 3k54A-3sxsA:
33.2		 3k54A-3sxsA:
62.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
ALA A  96
LYS A  98
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.63A 3k54A-3wigA:
22.7		 3k54A-3wigA:
25.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
ALA A1978
LYS A1980
MET A2001
ILE A2024
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.64A 3k54A-3zbfA:
26.9		 3k54A-3zbfA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.65A 3k54A-3zfxA:
32.4		 3k54A-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
LYS A 651
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
SER A 761
 None
 0.77A 3k54A-3zfxA:
32.4		 3k54A-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.67A 3k54A-4aw5A:
33.2		 3k54A-4aw5A:
37.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
ALA A  63
GLU A  81
VAL A  94
ILE A 108
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.73A 3k54A-4bc6A:
22.0		 3k54A-4bc6A:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.65A 3k54A-4c02A:
25.6		 3k54A-4c02A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
TYR A 703
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
 0.65A 3k54A-4ckrA:
29.4		 3k54A-4ckrA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 ALA A 588
LYS A 590
GLU A 607
VAL A 620
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.77A 3k54A-4e93A:
33.4		 3k54A-4e93A:
31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.60A 3k54A-4f4pA:
30.3		 3k54A-4f4pA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.62A 3k54A-4fodA:
27.2		 3k54A-4fodA:
35.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
ALA A 109
LYS A 111
GLU A 130
VAL A 143
ILE A 157
TYR A 161
 1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.5A)
None
1C7  A 401 (-3.5A)
 0.69A 3k54A-4i6fA:
22.3		 3k54A-4i6fA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.59A 3k54A-4k11A:
29.8		 3k54A-4k11A:
28.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
ALA A 506
LYS A 508
GLU A 525
MET A 529
TYR A 557
GLY A 561
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.71A 3k54A-4k33A:
31.5		 3k54A-4k33A:
35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  33
ALA A  54
LYS A  56
GLU A  70
MET A  74
VAL A  83
TYR A 101
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.79A 3k54A-4lg4A:
18.6		 3k54A-4lg4A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  33
ALA A  54
LYS A  56
MET A  74
VAL A  83
ILE A  97
TYR A 101
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.1A)
None
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.62A 3k54A-4lg4A:
18.6		 3k54A-4lg4A:
25.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
 0.65A 3k54A-4lggA:
30.8		 3k54A-4lggA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 273
ALA A 293
LYS A 295
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.49A 3k54A-4lggA:
30.8		 3k54A-4lggA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA B  51
LYS B  53
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
 0.60A 3k54A-4o27B:
19.8		 3k54A-4o27B:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.86A 3k54A-4o38A:
20.5		 3k54A-4o38A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.69A 3k54A-4o38A:
20.5		 3k54A-4o38A:
25.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 644
GLU A 663
MET A 667
ILE A 690
THR A 692
TYR A 694
GLY A 698
LEU A 746
 None
 0.96A 3k54A-4p2kA:
27.8		 3k54A-4p2kA:
39.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 644
ILE A 690
THR A 692
TYR A 694
GLY A 698
LEU A 746
SER A 756
 None
 0.53A 3k54A-4p2kA:
27.8		 3k54A-4p2kA:
39.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.75A 3k54A-4rt7A:
26.4		 3k54A-4rt7A:
31.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		10 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.55A 3k54A-4ueuA:
32.8		 3k54A-4ueuA:
47.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		10 LEU A  14
ALA A  35
LYS A  37
GLU A  52
VAL A  65
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.53A 3k54A-4ueuA:
32.8		 3k54A-4ueuA:
47.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
ALA A 214
LYS A 216
GLU A 235
VAL A 248
GLY A 270
LEU A 321
SER A 331
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
ANW  A 601 ( 4.0A)
 0.82A 3k54A-4wboA:
23.1		 3k54A-4wboA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 LEU B 267
ALA B 288
LYS B 290
MET B 309
VAL B 318
ILE B 332
THR B 334
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.55A 3k54A-4xeyB:
26.7		 3k54A-4xeyB:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 None
 0.77A 3k54A-4xi2A:
28.3		 3k54A-4xi2A:
65.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.66A 3k54A-4xufA:
30.0		 3k54A-4xufA:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		10 LEU A 408
ALA A 428
LYS A 430
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.64A 3k54A-4y93A:
35.3		 3k54A-4y93A:
60.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.67A 3k54A-5a46A:
30.5		 3k54A-5a46A:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.69A 3k54A-5f1zA:
28.4		 3k54A-5f1zA:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
ALA A 756
LYS A 758
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.64A 3k54A-5fm2A:
31.8		 3k54A-5fm2A:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.83A 3k54A-5grnA:
30.4		 3k54A-5grnA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 599
ALA A 625
LYS A 627
GLU A 644
VAL A 658
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.84A 3k54A-5grnA:
30.4		 3k54A-5grnA:
35.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 105
VAL A 134
ILE A 146
THR A 148
TYR A 150
GLY A 154
LEU A 215
 None
 0.65A 3k54A-5gz8A:
19.6		 3k54A-5gz8A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.66A 3k54A-5i3oA:
22.9		 3k54A-5i3oA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
GLU A  61
MET A  65
VAL A  74
ILE A  88
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
None
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.68A 3k54A-5j5tA:
22.1		 3k54A-5j5tA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.53A 3k54A-5j9zA:
30.6		 3k54A-5j9zA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 297
LYS A 299
GLU A 315
MET A 319
VAL A 328
TYR A 346
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
 0.64A 3k54A-5kbrA:
23.4		 3k54A-5kbrA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.53A 3k54A-5kbrA:
23.4		 3k54A-5kbrA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
TYR A 285
GLY A 289
LEU A 338
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.8A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.83A 3k54A-5ko1A:
27.4		 3k54A-5ko1A:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 119
LYS A 121
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
 None
 0.67A 3k54A-5u7qA:
19.4		 3k54A-5u7qA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 ALA A 707
LYS A 709
GLU A 725
VAL A 738
ILE A 752
GLY A 760
LEU A 810
SER A 821
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-4.1A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-2.7A)
 0.87A 3k54A-5vilA:
24.8		 3k54A-5vilA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 8 LEU A  24
ALA A  45
LYS A  47
ILE A  93
THR A  95
TYR A  97
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.66A 3k54A-5w5jA:
24.9		 3k54A-5w5jA:
29.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 7 ALA A  49
GLU A  69
MET A  73
TYR A  98
GLY A 102
LEU A 150
SER A 160
 VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
None
VX6  A 402 (-4.3A)
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-3.3A)
 0.69A 3k54A-5wnmA:
27.6		 3k54A-5wnmA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 LEU A 891
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.80A 3k54A-5wnoA:
27.9		 3k54A-5wnoA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 8 LEU A  33
ALA A  54
LYS A  56
VAL A  83
ILE A  97
TYR A 101
GLY A 105
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.65A 3k54A-6ao5A:
23.1		 3k54A-6ao5A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.62A 3k54A-6c7yA:
27.8		 3k54A-6c7yA:
14.34