SIMILAR PATTERNS OF AMINO ACIDS FOR 3K4V_D_ROCD201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28GLY A 48PRO A 81VAL A 82ILE A 84 | A79 A 800 (-3.2A)A79 A 800 (-4.1A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.74A | 3k4vC-1hvcA:14.0 | 3k4vC-1hvcA:46.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-3.4A)A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 4.9A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.57A | 3k4vC-1hvcA:14.0 | 3k4vC-1hvcA:46.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49VAL A 82ILE A 84 | A79 A 800 (-3.6A)A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 ( 4.7A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.44A | 3k4vC-1hvcA:14.0 | 3k4vC-1hvcA:46.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | LEU A 23ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 4.9A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.51A | 3k4vC-1hvcA:14.0 | 3k4vC-1hvcA:46.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | LEU A 23ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 ( 4.7A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.47A | 3k4vC-1hvcA:14.0 | 3k4vC-1hvcA:46.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyl | HYPODERMA LINEATUMCOLLAGENASE (Hypodermalineatum) |
PF00089(Trypsin) | 5 | LEU A 209ALA A 136GLY A 183VAL A 231ILE A 210 | None | 0.96A | 3k4vC-1hylA:undetectable | 3k4vC-1hylA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nov | NODAMURA VIRUS COATPROTEINS (Nodamura virus) |
PF01829(Peptidase_A6) | 5 | LEU A 113ALA A 173VAL A 190VAL A 301ILE A 299 | None | 0.96A | 3k4vC-1novA:undetectable | 3k4vC-1novA:15.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30VAL A 32PRO A 81ILE A 84 | None | 0.67A | 3k4vC-1q9pA:10.1 | 3k4vC-1q9pA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qap | QUINOLINIC ACIDPHOSPHORIBOSYLTRANSFERASE (Salmonellaenterica) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | LEU A 148ALA A 270VAL A 257VAL A 279ILE A 277 | None | 0.92A | 3k4vC-1qapA:undetectable | 3k4vC-1qapA:15.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ARG A 8ASP A 30GLY A 49ILE A 50PRO A 81 | None | 0.79A | 3k4vC-1sivA:18.1 | 3k4vC-1sivA:51.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 30GLY A 49PRO A 81ILE A 84 | None | 0.59A | 3k4vC-1sivA:18.1 | 3k4vC-1sivA:51.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29GLY A 49ILE A 50 | None | 1.07A | 3k4vC-1sivA:18.1 | 3k4vC-1sivA:51.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50PRO A 81 | None | 0.60A | 3k4vC-1sivA:18.1 | 3k4vC-1sivA:51.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 30GLY A 49PRO A 81ILE A 84 | None | 0.49A | 3k4vC-1sivA:18.1 | 3k4vC-1sivA:51.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uaa | PROTEIN(ATP-DEPENDENT DNAHELICASE REP.) (Escherichiacoli) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | LEU A 630ALA A 596ILE A 291ILE A 283PRO A 634 | None | 0.89A | 3k4vC-1uaaA:undetectable | 3k4vC-1uaaA:10.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uww | ENDOGLUCANASE (Bacillus akibai) |
PF03424(CBM_17_28) | 5 | ALA A 122VAL A 89ILE A 169VAL A 147ILE A 149 | None | 0.88A | 3k4vC-1uwwA:undetectable | 3k4vC-1uwwA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5f | PYRUVATE OXIDASE (Aerococcusviridans) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ASP A 388ALA A 444ASP A 442VAL A 466ILE A 440 | NoneTPP A1602 (-3.7A) MG A1603 ( 2.8A)NoneNone | 0.91A | 3k4vC-1v5fA:undetectable | 3k4vC-1v5fA:11.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | LEU A 70VAL A 139ILE A 120VAL A 89ILE A 91 | None | 0.87A | 3k4vC-1vknA:undetectable | 3k4vC-1vknA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wsv | AMINOMETHYLTRANSFERASE (Homo sapiens) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | LEU A 152VAL A 192GLY A 166VAL A 207ILE A 205 | LEU A 152 ( 0.6A)VAL A 192 ( 0.6A)GLY A 166 ( 0.0A)VAL A 207 ( 0.6A)ILE A 205 ( 0.4A) | 0.79A | 3k4vC-1wsvA:undetectable | 3k4vC-1wsvA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfj | CONSERVEDHYPOTHETICAL PROTEIN (Caulobactervibrioides) |
PF02578(Cu-oxidase_4) | 5 | ALA A 128VAL A 146ILE A 159GLY A 161VAL A 141 | None | 0.86A | 3k4vC-1xfjA:undetectable | 3k4vC-1xfjA:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | LEU A 374VAL A 48ILE A 5ILE A 65ILE A 47 | None | 1.02A | 3k4vC-2bb0A:undetectable | 3k4vC-2bb0A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cev | PROTEIN (ARGINASE) ([Bacillus]caldovelox) |
PF00491(Arginase) | 5 | LEU A 46ILE A 101GLY A 104PRO A 92ILE A 7 | None | 1.05A | 3k4vC-2cevA:undetectable | 3k4vC-2cevA:19.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 9 | ARG A 8LEU A 23ASP A 25ALA A 28VAL A 32ILE A 53GLY A 55PRO A 86ILE A 89 | LP1 A 201 (-3.5A)NoneLP1 A 201 (-2.3A)LP1 A 201 (-3.5A)NoneLP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.59A | 3k4vC-2fmbA:15.2 | 3k4vC-2fmbA:33.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 9 | LEU A 23ASP A 25ALA A 28VAL A 32ILE A 53GLY A 55PRO A 86VAL A 87ILE A 89 | NoneLP1 A 201 (-2.3A)LP1 A 201 (-3.5A)NoneLP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 ( 4.9A)LP1 A 201 (-4.2A) | 0.60A | 3k4vC-2fmbA:15.2 | 3k4vC-2fmbA:33.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hjh | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 5 | LEU A 509ALA A 517ILE A 329VAL A 493ILE A 495 | None | 1.07A | 3k4vC-2hjhA:undetectable | 3k4vC-2hjhA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ma4 | PUTATIVE PERIPLASMICPROTEIN (Salmonellaenterica) |
PF07338(DUF1471) | 5 | VAL A 70ILE A 43GLY A 83ILE A 81ILE A 24 | None | 1.01A | 3k4vC-2ma4A:undetectable | 3k4vC-2ma4A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0l | THIOREDOXINREDUCTASE (Helicobacterpylori) |
PF07992(Pyr_redox_2) | 5 | ALA A 5VAL A 84ILE A 108GLY A 8ILE A 93 | NoneNoneNoneFAD A 400 (-3.2A)None | 0.80A | 3k4vC-2q0lA:undetectable | 3k4vC-2q0lA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qdl | CHEMOTAXIS SIGNALTRANSDUCTION PROTEIN (Caldanaerobactersubterraneus) |
PF01584(CheW) | 5 | LEU A 95VAL A 34ILE A 14VAL A 86ILE A 84 | NoneGOL A 166 ( 4.5A)NoneNoneNone | 0.83A | 3k4vC-2qdlA:undetectable | 3k4vC-2qdlA:22.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 ( 4.7A)NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.51A | 3k4vC-2rkfA:20.5 | 3k4vC-2rkfA:82.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vbf | BRANCHED-CHAINALPHA-KETOACIDDECARBOXYLASE (Lactococcuslactis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | LEU A 295ALA A 273ASP A 274ILE A 236ILE A 276 | LEU A 295 ( 0.6A)ALA A 273 ( 0.0A)ASP A 274 ( 0.6A)ILE A 236 ( 0.6A)ILE A 276 ( 0.6A) | 1.05A | 3k4vC-2vbfA:undetectable | 3k4vC-2vbfA:11.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wab | ENDOGLUCANASE E (Ruminiclostridiumthermocellum) |
PF00657(Lipase_GDSL) | 5 | ARG A 16ALA A 159ILE A 327ILE A 219PRO A 214 | None | 1.02A | 3k4vC-2wabA:undetectable | 3k4vC-2wabA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whl | BETA-MANNANASE (Salipaludibacillusagaradhaerens) |
PF00150(Cellulase) | 5 | LEU A 157VAL A 85ILE A 69ILE A 107ILE A 122 | None | 0.99A | 3k4vC-2whlA:undetectable | 3k4vC-2whlA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whl | BETA-MANNANASE (Salipaludibacillusagaradhaerens) |
PF00150(Cellulase) | 5 | LEU A 157VAL A 85ILE A 73ILE A 114ILE A 122 | None | 1.03A | 3k4vC-2whlA:undetectable | 3k4vC-2whlA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wia | FERROUS IRONTRANSPORT PROTEIN B (Klebsiellapneumoniae) |
PF02421(FeoB_N) | 5 | LEU A 8VAL A 116ILE A 156VAL A 92ILE A 90 | None | 0.90A | 3k4vC-2wiaA:undetectable | 3k4vC-2wiaA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASEIRON-SULFURATP-BINDING PROTEINLIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Prochlorococcusmarinus) |
PF00142(Fer4_NifH)PF00148(Oxidored_nitro) | 5 | LEU A 87ALA C 71GLY A 126VAL A 83ILE A 84 | NoneNoneSF4 A1302 (-3.9A)NoneEPE A1298 (-4.9A) | 1.02A | 3k4vC-2ynmA:undetectable | 3k4vC-2ynmA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3adp | LAMBDA-CRYSTALLIN (Oryctolaguscuniculus) |
PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ARG A 50LEU A 72VAL A 32GLY A 18ILE A 75 | None | 1.04A | 3k4vC-3adpA:undetectable | 3k4vC-3adpA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ftb | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Clostridiumacetobutylicum) |
PF00155(Aminotran_1_2) | 5 | ALA A 173VAL A 148ILE A 138ILE A 167ILE A 180 | None | 0.99A | 3k4vC-3ftbA:undetectable | 3k4vC-3ftbA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gip | N-ACYL-D-GLUTAMATEDEACYLASE (Bordetellabronchiseptica) |
PF07969(Amidohydro_3) | 5 | ALA A 27VAL A 58ILE A 11GLY A 30ILE A 16 | None | 0.96A | 3k4vC-3gipA:undetectable | 3k4vC-3gipA:10.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdf | LYSOZYME (Escherichiavirus Lambda) |
PF00959(Phage_lysozyme) | 5 | ALA A 131ASP A 127GLY A 163PRO A 95ILE A 123 | None | 0.98A | 3k4vC-3hdfA:undetectable | 3k4vC-3hdfA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdy | UDP-GALACTOPYRANOSEMUTASE (Deinococcusradiodurans) |
PF03275(GLF)PF13450(NAD_binding_8) | 5 | LEU A 230ALA A 49ILE A 256VAL A 237ILE A 235 | None | 1.00A | 3k4vC-3hdyA:undetectable | 3k4vC-3hdyA:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i0m | DNA REPAIR ANDTELOMERE MAINTENANCEPROTEIN NBS1 (Schizosaccharomycespombe) |
PF00498(FHA) | 5 | ILE A 52GLY A 137ILE A 138VAL A 191ILE A 17 | None | 0.89A | 3k4vC-3i0mA:undetectable | 3k4vC-3i0mA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krz | NADH:FLAVINOXIDOREDUCTASE/NADHOXIDASE (Thermoanaerobacterpseudethanolicus) |
PF00724(Oxidored_FMN) | 5 | LEU A 101VAL A 215ILE A 239VAL A 160ILE A 162 | None | 0.90A | 3k4vC-3krzA:undetectable | 3k4vC-3krzA:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lkb | PROBABLEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER, AMINOACID BINDING PROTEIN (Thermusthermophilus) |
PF13458(Peripla_BP_6) | 5 | ALA A 167VAL A 146ILE A 137VAL A 177ILE A 174 | None | 0.80A | 3k4vC-3lkbA:undetectable | 3k4vC-3lkbA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lun | ULILYSIN (Methanosarcinaacetivorans) |
PF05572(Peptidase_M43) | 5 | ALA A 209ASP A 207VAL A 175ILE A 82ILE A 205 | None | 0.87A | 3k4vC-3lunA:undetectable | 3k4vC-3lunA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lun | ULILYSIN (Methanosarcinaacetivorans) |
PF05572(Peptidase_M43) | 6 | ALA A 209ASP A 207VAL A 175ILE A 93VAL A 203ILE A 205 | None | 1.13A | 3k4vC-3lunA:undetectable | 3k4vC-3lunA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdo | PUTATIVEPHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Parabacteroidesdistasonis) |
PF02769(AIRS_C) | 5 | LEU A 251ALA A 255ASP A 246ILE A 319ILE A 248 | None | 0.97A | 3k4vC-3mdoA:undetectable | 3k4vC-3mdoA:14.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ASP A 30VAL A 32GLY A 48PRO A 81 | None | 0.75A | 3k4vC-3mwsA:19.6 | 3k4vC-3mwsA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 30VAL A 32PRO A 81VAL A 82 | None | 0.59A | 3k4vC-3mwsA:19.6 | 3k4vC-3mwsA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23VAL A 32ILE A 50PRO A 81VAL A 82 | None | 0.78A | 3k4vC-3mwsA:19.6 | 3k4vC-3mwsA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ALA A 28ASP A 29GLY A 49ILE A 50 | None | 1.28A | 3k4vC-3mwsA:19.6 | 3k4vC-3mwsA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25ALA A 28ASP A 30VAL A 32PRO A 81VAL A 82ILE A 84 | None | 0.54A | 3k4vC-3mwsA:19.6 | 3k4vC-3mwsA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | LEU A 23ASP A 25ALA A 28VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | None | 0.52A | 3k4vC-3mwsA:19.6 | 3k4vC-3mwsA:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 5 | ALA A 134VAL A 259ILE A 309GLY A 305ILE A 261 | NoneFMT A 465 ( 4.3A)FMT A 465 (-4.9A)NoneNone | 0.99A | 3k4vC-3oksA:undetectable | 3k4vC-3oksA:12.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qtg | PYRUVATE KINASE (Pyrobaculumaerophilum) |
PF00224(PK)PF02887(PK_C) | 6 | LEU A 23ALA A 52VAL A 79ILE A 190VAL A 45ILE A 47 | None | 1.43A | 3k4vC-3qtgA:undetectable | 3k4vC-3qtgA:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slz | GAG-PRO-POLPOLYPROTEIN (Murine leukemiavirus) |
PF00077(RVP) | 5 | LEU A 30ASP A 32ALA A 35VAL A 39GLY A 56 | None3TL A 126 (-2.4A)3TL A 126 ( 4.0A)None3TL A 126 (-3.4A) | 0.66A | 3k4vC-3slzA:11.2 | 3k4vC-3slzA:25.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49PRO A 81 | SO4 A 101 (-4.2A)017 A 201 (-3.5A)017 A 201 (-4.2A)NoneNone017 A 201 (-4.0A)None | 0.61A | 3k4vC-3t3cA:18.4 | 3k4vC-3t3cA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50 | SO4 A 101 (-4.2A)017 A 201 (-2.6A)017 A 201 (-3.5A)017 A 201 (-4.2A)NoneNone017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.38A | 3k4vC-3t3cA:18.4 | 3k4vC-3t3cA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29GLY A 49ILE A 50 | 017 A 201 ( 4.8A)None017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-3.0A)017 A 201 (-3.3A) | 1.41A | 3k4vC-3ttpA:19.2 | 3k4vC-3ttpA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30ILE A 50PRO A 81ILE A 84 | 017 A 201 ( 4.8A)None017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-4.6A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.58A | 3k4vC-3ttpA:19.2 | 3k4vC-3ttpA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | 017 A 201 ( 4.8A)None017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.51A | 3k4vC-3ttpA:19.2 | 3k4vC-3ttpA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50PRO A 81 | NoneNone017 A 202 ( 2.5A)017 A 201 (-3.4A)017 A 201 ( 4.0A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.47A | 3k4vC-3u7sA:19.7 | 3k4vC-3u7sA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30ILE A 47GLY A 49PRO A 81 | NoneNone017 A 202 ( 2.5A)017 A 201 (-3.4A)017 A 201 ( 4.0A)017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 202 (-4.0A) | 0.45A | 3k4vC-3u7sA:19.7 | 3k4vC-3u7sA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxm | PROTEIN PELOTAHOMOLOG (Aeropyrumpernix) |
PF03463(eRF1_1)PF03465(eRF1_3) | 5 | ALA B 129VAL B 195ILE B 244ILE B 250VAL B 232 | None | 1.06A | 3k4vC-3wxmB:undetectable | 3k4vC-3wxmB:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2l | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE/RESPONSE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 5 | ARG A 505VAL A 558GLY A 515ILE A 500ILE A 548 | None | 1.03A | 3k4vC-4a2lA:undetectable | 3k4vC-4a2lA:8.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a9a | RIBOSOME-INTERACTINGGTPASE 1 (Saccharomycescerevisiae) |
PF01926(MMR_HSR1)PF02824(TGS)PF16897(MMR_HSR1_Xtn) | 5 | LEU A 145ILE A 122GLY A 72ILE A 149VAL A 68 | None | 0.77A | 3k4vC-4a9aA:undetectable | 3k4vC-4a9aA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ao7 | ESTERASE (unidentified) |
PF12146(Hydrolase_4) | 5 | ALA A 125VAL A 31ILE A 119PRO A 82ILE A 79 | None | 0.84A | 3k4vC-4ao7A:undetectable | 3k4vC-4ao7A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbr | BETA-2 ADRENERGICRECEPTOR (Homo sapiens) |
PF00001(7tm_1) | 5 | VAL A 44GLY A 90ILE A 94VAL A 39ILE A 43 | None | 0.93A | 3k4vC-4gbrA:undetectable | 3k4vC-4gbrA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1g | MALTOSE BINDINGPROTEIN-CAKAR3 MOTORDOMAIN FUSIONPROTEIN (Candidaalbicans;Escherichiacoli) |
PF00225(Kinesin)PF13416(SBP_bac_8) | 5 | LEU A 625VAL A 680ILE A 587VAL A 621ILE A 622 | None | 1.03A | 3k4vC-4h1gA:undetectable | 3k4vC-4h1gA:9.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hv4 | UDP-N-ACETYLMURAMATE--L-ALANINE LIGASE (Yersinia pestis) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | LEU A 348VAL A 376ILE A 453VAL A 462ILE A 460 | None | 1.06A | 3k4vC-4hv4A:undetectable | 3k4vC-4hv4A:11.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inj | LMO1638 PROTEIN (Listeriamonocytogenes) |
PF02016(Peptidase_S66) | 5 | LEU A 162ALA A 309GLY A 306ILE A 305ILE A 321 | None | 0.96A | 3k4vC-4injA:undetectable | 3k4vC-4injA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k9d | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Brugia malayi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ALA A 22VAL A 6ILE A 333ILE A 14VAL A 33 | NoneNoneNoneNAD A 401 (-3.9A)None | 0.96A | 3k4vC-4k9dA:undetectable | 3k4vC-4k9dA:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mso | SERINEHYDROXYMETHYLTRANSFERASE (Burkholderiacenocepacia) |
PF00464(SHMT) | 5 | ARG A 294ASP A 320VAL A 319GLY A 304ILE A 307 | None | 0.90A | 3k4vC-4msoA:undetectable | 3k4vC-4msoA:13.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ASP A 30VAL A 32GLY A 48PRO A 81 | RIT A 500 (-3.6A)RIT A 500 (-4.8A)NoneRIT A 500 (-4.8A)RIT A 500 (-3.9A) | 0.74A | 3k4vC-4njvA:20.5 | 3k4vC-4njvA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ARG A 8LEU A 23ASP A 25ALA A 28VAL A 32ILE A 47GLY A 49ILE A 50ILE A 84 | RIT A 500 (-3.2A)NoneRIT A 500 (-2.4A)RIT A 500 (-3.6A)NoneRIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-4.3A) | 0.42A | 3k4vC-4njvA:20.5 | 3k4vC-4njvA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 30VAL A 32PRO A 81ILE A 84 | NoneRIT A 500 (-2.4A)RIT A 500 (-3.6A)RIT A 500 (-4.8A)NoneRIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.51A | 3k4vC-4njvA:20.5 | 3k4vC-4njvA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | LEU A 23ASP A 25ALA A 28VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | NoneRIT A 500 (-2.4A)RIT A 500 (-3.6A)NoneRIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.50A | 3k4vC-4njvA:20.5 | 3k4vC-4njvA:84.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 5 | LEU A 396VAL A 76ILE A 381ILE A 87ILE A 394 | None | 0.77A | 3k4vC-4nkyA:undetectable | 3k4vC-4nkyA:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pyr | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Chromobacteriumviolaceum) |
PF04348(LppC) | 5 | LEU A 166VAL A 88GLY A 107ILE A 337ILE A 146 | None | 0.81A | 3k4vC-4pyrA:undetectable | 3k4vC-4pyrA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r37 | PUTATIVEACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Bacteroidesfragilis) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | LEU A 110ALA A 60ILE A 44GLY A 63ILE A 86 | None | 1.06A | 3k4vC-4r37A:undetectable | 3k4vC-4r37A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ry9 | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Verminephrobactereiseniae) |
PF13407(Peripla_BP_4) | 5 | LEU A 105ASP A 86GLY A 39ILE A 96VAL A 109 | None | 1.03A | 3k4vC-4ry9A:undetectable | 3k4vC-4ry9A:16.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ARG A 10LEU A 30ASP A 32ALA A 35GLY A 58 | NoneNone4B1 A 201 (-2.9A)4B1 A 201 (-3.6A)4B1 A 201 (-3.4A) | 0.41A | 3k4vC-4ydfA:12.7 | 3k4vC-4ydfA:32.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 6 | ARG A 10LEU A 30ASP A 32ALA A 35VAL A 39ILE A 100 | NoneNone4B1 A 201 (-2.9A)4B1 A 201 (-3.6A)None4B1 A 201 (-4.8A) | 0.51A | 3k4vC-4ydfA:12.7 | 3k4vC-4ydfA:32.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z26 | PUTATIVE GMC-TYPEOXIDOREDUCTASE R135 (Acanthamoebapolyphagamimivirus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | LEU A 36VAL A 296ILE A 267VAL A 10ILE A 12 | None | 0.90A | 3k4vC-4z26A:undetectable | 3k4vC-4z26A:10.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8ALA A 28ASP A 30GLY A 49ILE A 84 | None | 0.78A | 3k4vC-5b18A:18.1 | 3k4vC-5b18A:73.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cw5 | BRCA1/BRCA2-CONTAINING COMPLEX SUBUNIT 3 (Camponotusfloridanus) |
PF01398(JAB) | 5 | LEU A 79VAL A 89GLY A 33ILE A 51ILE A 36 | None | 0.92A | 3k4vC-5cw5A:undetectable | 3k4vC-5cw5A:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dlq | EXPORTIN-4 (Mus musculus) |
no annotation | 5 | LEU B 608ALA B 667ILE B 660VAL B 604ILE B 605 | None | 0.92A | 3k4vC-5dlqB:undetectable | 3k4vC-5dlqB:6.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ija | HYDROGENASE-SPECIFICMATURATIONENDOPEPTIDASE (Thermococcuskodakarensis) |
PF01750(HycI) | 5 | VAL A 69ILE A 142ILE A 25VAL A 132ILE A 117 | None | 0.87A | 3k4vC-5ijaA:undetectable | 3k4vC-5ijaA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5izk | SELENOCYSTEINE-SPECIFIC ELONGATIONFACTOR (Homo sapiens) |
PF00009(GTP_EFTU) | 5 | ALA A 315VAL A 428GLY A 346VAL A 319ILE A 317 | None | 0.99A | 3k4vC-5izkA:undetectable | 3k4vC-5izkA:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lcn | UNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF12146(Hydrolase_4) | 5 | LEU A 159VAL A 214ILE A 175ILE A 228ILE A 156 | None | 1.04A | 3k4vC-5lcnA:undetectable | 3k4vC-5lcnA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nva | PUTATIVESODIUM:SOLUTESYMPORTER (Proteusmirabilis) |
no annotation | 5 | ALA A 392ILE A 344GLY A 385ILE A 386ILE A 159 | None | 0.80A | 3k4vC-5nvaA:undetectable | 3k4vC-5nvaA:20.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29GLY A 49ILE A 50 | None | 1.48A | 3k4vC-5t2zA:19.8 | 3k4vC-5t2zA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.56A | 3k4vC-5t2zA:19.8 | 3k4vC-5t2zA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT FWDG (Methanothermobacterwolfeii) |
PF12838(Fer4_7) | 5 | LEU G 60ILE G 76PRO G 23VAL G 24ILE G 45 | NoneSF4 G 101 ( 3.8A)NoneNoneSF4 G 102 ( 3.9A) | 1.03A | 3k4vC-5t5iG:undetectable | 3k4vC-5t5iG:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ur0 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Naegleriagruberi) |
no annotation | 5 | VAL A 28ILE A 31GLY A 13ILE A 12ILE A 4 | NoneNoneNoneNAD A 401 (-4.1A)None | 0.97A | 3k4vC-5ur0A:undetectable | 3k4vC-5ur0A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmt | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Neisseriagonorrhoeae) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | LEU A 94VAL A 32ILE A 65VAL A 5ILE A 7 | None | 0.80A | 3k4vC-5vmtA:undetectable | 3k4vC-5vmtA:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S23,PUTATIVE (Trichomonasvaginalis) |
PF00164(Ribosom_S12_S23) | 5 | LEU X 75ALA X 84VAL X 52ILE X 95ILE X 124 | NoneNoneNoneNone C 2 27 ( 4.6A) | 0.92A | 3k4vC-5xyiX:undetectable | 3k4vC-5xyiX:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z2e | DIHYDRODIPICOLINATEREDUCTASE (Paenisporosarcinasp. TG-14) |
no annotation | 5 | LEU A 73ASP A 34VAL A 32VAL A 4ILE A 6 | None | 0.99A | 3k4vC-5z2eA:undetectable | 3k4vC-5z2eA:22.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ARG A 13LEU A 28ASP A 30ALA A 33GLY A 58VAL A 99 | NoneNone3TL A 201 (-3.5A)3TL A 201 (-4.0A)3TL A 201 (-3.4A)None | 0.51A | 3k4vC-6fivA:15.5 | 3k4vC-6fivA:30.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 30GLY A 49PRO A 81ILE A 84 | NoneNIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNIU A 100 ( 3.8A)NoneNone | 0.68A | 3k4vC-6upjA:18.1 | 3k4vC-6upjA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | NoneNIU A 100 (-2.8A)NoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 0.75A | 3k4vC-6upjA:18.1 | 3k4vC-6upjA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aha | ALPHA-MOMORCHARIN (Momordicacharantia) |
PF00161(RIP) | 4 | GLY A 8ASP A 10GLY A 15THR A 157 | None | 0.97A | 3k4vC-1ahaA:undetectable | 3k4vC-1ahaA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bru | ELASTASE (Sus scrofa) |
PF00089(Trypsin) | 4 | GLY P 184ASP P 186GLY P 18THR P 146 | None | 1.03A | 3k4vC-1bruP:undetectable | 3k4vC-1bruP:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fcd | FLAVOCYTOCHROME CSULFIDEDEHYDROGENASE(CYTOCHROME SUBUNIT)FLAVOCYTOCHROME CSULFIDEDEHYDROGENASE(FLAVIN-BINDINGSUBUNIT) (Allochromatiumvinosum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind)no annotation | 4 | GLY C 13ASP A 398GLY A 13THR A 41 | NoneNoneFAD A 699 (-3.4A)None | 1.04A | 3k4vC-1fcdC:undetectable | 3k4vC-1fcdC:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpe | PROTEIN (GLUCOSEOXIDASE) (Penicilliumamagasakiense) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | GLY A 350ASP A 420GLY A 112THR A 116 | NoneNoneFAD A 600 (-3.3A)None | 1.10A | 3k4vC-1gpeA:undetectable | 3k4vC-1gpeA:9.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | A79 A 800 (-3.0A)A79 A 800 (-2.7A)A79 A 800 (-4.1A)None | 0.29A | 3k4vC-1hvcA:14.0 | 3k4vC-1hvcA:46.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | A79 A 800 (-3.0A)A79 A 800 (-2.8A)A79 A 800 (-3.6A)None | 0.35A | 3k4vC-1hvcA:14.0 | 3k4vC-1hvcA:46.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nkv | HYPOTHETICAL PROTEINYJHP (Escherichiacoli) |
PF13847(Methyltransf_31) | 4 | GLY A 97ASP A 94GLY A 44THR A 63 | None | 0.74A | 3k4vC-1nkvA:undetectable | 3k4vC-1nkvA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pby | QUINOHEMOPROTEINAMINE DEHYDROGENASE40 KDA SUBUNIT (Paracoccusdenitrificans) |
no annotation | 4 | GLY B 297ASP B 302GLY B 315THR B 18 | None | 0.97A | 3k4vC-1pbyB:undetectable | 3k4vC-1pbyB:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s3g | ADENYLATE KINASE (Sporosarcinaglobispora) |
PF00406(ADK)PF05191(ADK_lid) | 4 | GLY A 32ASP A 84GLY A 7THR A 89 | AP5 A 218 (-3.6A)AP5 A 218 ( 4.7A)NoneNone | 0.98A | 3k4vC-1s3gA:undetectable | 3k4vC-1s3gA:18.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | None | 0.33A | 3k4vC-1sivA:18.1 | 3k4vC-1sivA:51.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1spj | KALLIKREIN 1 (Homo sapiens) |
PF00089(Trypsin) | 4 | GLY A 19ASP A 159GLY A 184THR A 213 | None | 0.84A | 3k4vC-1spjA:undetectable | 3k4vC-1spjA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqj | OLIGOXYLOGLUCANREDUCING-END-SPECIFIC CELLOBIOHYDROLASE (Geotrichum sp.M128) |
PF15899(BNR_6) | 4 | GLY A 15ASP A 465GLY A 382THR A 391 | None | 0.88A | 3k4vC-1sqjA:undetectable | 3k4vC-1sqjA:9.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txo | PUTATIVE BACTERIALENZYME (Mycobacteriumtuberculosis) |
PF13672(PP2C_2) | 4 | GLY A 117ASP A 135GLY A 121THR A 176 | None | 1.07A | 3k4vC-1txoA:undetectable | 3k4vC-1txoA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v7v | CHITOBIOSEPHOSPHORYLASE (Vibrioproteolyticus) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | GLY A 770ASP A 736GLY A 783THR A 775 | None | 0.88A | 3k4vC-1v7vA:undetectable | 3k4vC-1v7vA:9.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkr | POLYPOROPEPSIN (Irpex lacteus) |
PF00026(Asp) | 4 | GLY A 103ASP A 95GLY A 70THR A 116 | NoneSO4 A 904 (-4.2A)SO4 A 902 (-3.3A)None | 0.89A | 3k4vC-1wkrA:7.5 | 3k4vC-1wkrA:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wql | IRON-SULFUR PROTEINLARGE SUBUNIT OFCUMENE DIOXYGENASE (Pseudomonasfluorescens) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 4 | GLY A 389ASP A 387GLY A 382THR A 338 | None | 0.95A | 3k4vC-1wqlA:undetectable | 3k4vC-1wqlA:12.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yoa | PUTATIVEFLAVOPROTEIN (Thermusthermophilus) |
PF01613(Flavin_Reduct) | 4 | GLY A 154ASP A 152GLY A 16THR A 32 | None | 0.86A | 3k4vC-1yoaA:undetectable | 3k4vC-1yoaA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zip | ADENYLATE KINASE (Geobacillusstearothermophilus) |
PF00406(ADK)PF05191(ADK_lid) | 4 | GLY A 32ASP A 84GLY A 7THR A 89 | AP5 A 218 (-3.6A) MN A 220 ( 4.3A)NoneNone | 0.90A | 3k4vC-1zipA:undetectable | 3k4vC-1zipA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2drm | ACANTHAMOEBA MYOSINIB (Acanthamoeba) |
PF00018(SH3_1) | 4 | GLY A 38ASP A 35GLY A 49THR A 17 | None | 0.97A | 3k4vC-2drmA:undetectable | 3k4vC-2drmA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9y | ACETYL-COENZYME ACARBOXYLASE CARBOXYLTRANSFERASE SUBUNITBETA (Escherichiacoli) |
PF01039(Carboxyl_trans) | 4 | GLY B 135ASP B 106GLY B 131THR B 202 | None | 1.00A | 3k4vC-2f9yB:undetectable | 3k4vC-2f9yB:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gt1 | LIPOPOLYSACCHARIDEHEPTOSYLTRANSFERASE-1 (Escherichiacoli) |
PF01075(Glyco_transf_9) | 4 | GLY A 288ASP A 283GLY A 280THR A 188 | None | 0.93A | 3k4vC-2gt1A:undetectable | 3k4vC-2gt1A:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qt3 | N-ISOPROPYLAMMELIDEISOPROPYLAMIDOHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 4 | GLY A 320ASP A 316GLY A 118THR A 122 | None | 1.08A | 3k4vC-2qt3A:undetectable | 3k4vC-2qt3A:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rij | PUTATIVE2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATEN-SUCCINYLTRANSFERASE (Campylobacterjejuni) |
PF14602(Hexapep_2)PF14789(THDPS_M)PF14790(THDPS_N) | 4 | GLY A 267ASP A 310GLY A 355THR A 304 | None | 0.97A | 3k4vC-2rijA:undetectable | 3k4vC-2rijA:15.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | AB1 A 501 (-3.9A)AB1 A 501 ( 3.3A)AB1 A 501 (-4.2A)None | 0.25A | 3k4vC-2rkfA:20.5 | 3k4vC-2rkfA:82.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vak | SIGMA A (Avianorthoreovirus) |
PF03084(Sigma_1_2) | 4 | GLY A 167ASP A 408GLY A 412THR A 343 | None | 1.08A | 3k4vC-2vakA:undetectable | 3k4vC-2vakA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2we9 | MOBA-RELATED PROTEIN (Mycobacteriumtuberculosis) |
PF12804(NTP_transf_3) | 4 | GLY A 68ASP A 70GLY A 8THR A 37 | None | 1.02A | 3k4vC-2we9A:undetectable | 3k4vC-2we9A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 4 | GLY A 292ASP A 222GLY A 210THR A 216 | NoneNoneNonePP6 A 327 (-3.6A) | 0.94A | 3k4vC-2wedA:7.9 | 3k4vC-2wedA:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wjs | LAMININ SUBUNITALPHA-2 (Mus musculus) |
PF00054(Laminin_G_1) | 4 | GLY A2455ASP A2383GLY A2403THR A2447 | CA A5002 (-3.5A) CA A5003 ( 2.7A)NoneNone | 0.96A | 3k4vC-2wjsA:undetectable | 3k4vC-2wjsA:11.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wla | DPS-LIKE PEROXIDERESISTANCE PROTEIN (Streptococcuspyogenes) |
PF00210(Ferritin) | 4 | GLY A 143ASP A 140GLY A 135THR A 14 | None | 0.96A | 3k4vC-2wlaA:undetectable | 3k4vC-2wlaA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wv3 | NEUROPLASTIN (Rattusnorvegicus) |
PF13927(Ig_3) | 4 | GLY A 118ASP A 94GLY A 97THR A 153 | None | 1.08A | 3k4vC-2wv3A:undetectable | 3k4vC-2wv3A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xf2 | CATALASE (Penicilliumjanthinellum) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | GLY A 107ASP A 117GLY A 120THR A 68 | NoneNoneHDD A 690 (-3.5A)None | 0.87A | 3k4vC-2xf2A:undetectable | 3k4vC-2xf2A:8.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgw | PEROXIDE RESISTANCEPROTEIN (Streptococcuspyogenes) |
PF00210(Ferritin) | 4 | GLY A 143ASP A 140GLY A 135THR A 14 | None | 0.99A | 3k4vC-2xgwA:undetectable | 3k4vC-2xgwA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yev | CYTOCHROME C OXIDASEPOLYPEPTIDE I+III (Thermusthermophilus) |
PF00115(COX1)PF00510(COX3) | 4 | GLY A 235ASP A 237GLY A 638THR A 731 | None | 1.03A | 3k4vC-2yevA:undetectable | 3k4vC-2yevA:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1u | HYDROGENASEEXPRESSION/FORMATIONPROTEIN HYPE (Desulfovibriovulgaris) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | GLY A 176ASP A 174GLY A 270THR A 70 | None | 0.96A | 3k4vC-2z1uA:undetectable | 3k4vC-2z1uA:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b8l | UNCHARACTERIZEDPROTEIN (Novosphingobiumaromaticivorans) |
PF13577(SnoaL_4) | 4 | GLY A 85ASP A 7GLY A 122THR A 126 | None | 0.91A | 3k4vC-3b8lA:undetectable | 3k4vC-3b8lA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b96 | VERY LONG-CHAINSPECIFIC ACYL-COADEHYDROGENASE (Homo sapiens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | GLY A 261ASP A 83GLY A 407THR A 311 | None | 0.99A | 3k4vC-3b96A:undetectable | 3k4vC-3b96A:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cj1 | ECTONUCLEOSIDETRIPHOSPHATEDIPHOSPHOHYDROLASE 2 (Rattusnorvegicus) |
PF01150(GDA1_CD39) | 4 | GLY A 120ASP A 45GLY A 439THR A 445 | None | 1.10A | 3k4vC-3cj1A:undetectable | 3k4vC-3cj1A:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da1 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Bacillushalodurans) |
PF01266(DAO)PF16901(DAO_C) | 4 | GLY A 41ASP A 20GLY A 391THR A 384 | None | 0.91A | 3k4vC-3da1A:undetectable | 3k4vC-3da1A:11.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dl0 | ADENYLATE KINASE (Bacillussubtilis) |
PF00406(ADK)PF05191(ADK_lid) | 4 | GLY A 32ASP A 84GLY A 7THR A 89 | AP5 A 218 (-3.5A) MG A 220 ( 4.3A)NoneNone | 0.96A | 3k4vC-3dl0A:undetectable | 3k4vC-3dl0A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqn | GLUCAN1,3-BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF12708(Pectate_lyase_3) | 4 | GLY A 518ASP A 509GLY A 600THR A 559 | NoneNone ZN A 756 (-4.5A)None | 0.93A | 3k4vC-3eqnA:undetectable | 3k4vC-3eqnA:8.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f5d | PROTEIN YDEA (Bacillussubtilis) |
PF01965(DJ-1_PfpI) | 4 | GLY A 71ASP A 73GLY A 47THR A 51 | None | 1.00A | 3k4vC-3f5dA:undetectable | 3k4vC-3f5dA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzy | BIPHENYL DIOXYGENASESUBUNIT ALPHA (Comamonastestosteroni) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 4 | GLY A 387ASP A 385GLY A 380THR A 336 | None | 1.01A | 3k4vC-3gzyA:undetectable | 3k4vC-3gzyA:12.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kvn | ESTERASE ESTA (Pseudomonasaeruginosa) |
no annotation | 4 | GLY X 144ASP X 148GLY X 165THR X 217 | None | 1.02A | 3k4vC-3kvnX:undetectable | 3k4vC-3kvnX:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ll9 | ISOPENTENYLPHOSPHATE KINASE (Methanothermobacterthermautotrophicus) |
PF00696(AA_kinase) | 4 | GLY A 219ASP A 158GLY A 176THR A 260 | ADP A 267 (-3.4A)ADP A 267 ( 4.4A)NoneNone | 0.95A | 3k4vC-3ll9A:undetectable | 3k4vC-3ll9A:16.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | None | 0.43A | 3k4vC-3mwsA:19.6 | 3k4vC-3mwsA:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ot4 | PUTATIVEISOCHORISMATASE (Bordetellabronchiseptica) |
PF00857(Isochorismatase) | 4 | GLY A 43ASP A 174GLY A 144THR A 51 | None | 0.89A | 3k4vC-3ot4A:undetectable | 3k4vC-3ot4A:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qde | CELLOBIOSEPHOSPHORYLASE (Ruminiclostridiumthermocellum) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | GLY A 779ASP A 745GLY A 792THR A 784 | None | 0.99A | 3k4vC-3qdeA:undetectable | 3k4vC-3qdeA:9.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5b | TETRAHYDRODIPICOLINATEN-SUCCINYLETRANSFERASE (Pseudomonasaeruginosa) |
PF14602(Hexapep_2)PF14789(THDPS_M)PF14790(THDPS_N) | 4 | GLY A 259ASP A 235GLY A 263THR A 242 | None | 1.10A | 3k4vC-3r5bA:undetectable | 3k4vC-3r5bA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sul | CERATO-PLATANIN-LIKEPROTEIN (Moniliophthoraperniciosa) |
PF07249(Cerato-platanin) | 4 | GLY A 67ASP A 94GLY A 33THR A 46 | None | 0.90A | 3k4vC-3sulA:undetectable | 3k4vC-3sulA:22.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | 017 A 201 (-3.6A)017 A 201 (-3.3A)NoneNone | 0.40A | 3k4vC-3ttpA:19.2 | 3k4vC-3ttpA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | 017 A 201 ( 3.5A)017 A 201 (-3.2A)017 A 202 ( 4.6A)None | 0.43A | 3k4vC-3u7sA:19.7 | 3k4vC-3u7sA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw2 | PHOSPHOGLUCOMUTASE/PHOSPHOMANNOMUTASEFAMILY PROTEIN (Burkholderiathailandensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | GLY A 400ASP A 448GLY A 419THR A 437 | None | 1.09A | 3k4vC-3uw2A:undetectable | 3k4vC-3uw2A:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiw | GLYCOSYL HYDROLASEFAMILY 88 (Pedobacterheparinus) |
PF07470(Glyco_hydro_88) | 4 | GLY A 362ASP A 305GLY A 247THR A 234 | None | 0.72A | 3k4vC-3wiwA:undetectable | 3k4vC-3wiwA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zt9 | SERINE PHOSPHATASE (Moorellathermoacetica) |
PF07228(SpoIIE) | 4 | GLY A 37ASP A 21GLY A 41THR A 79 | None MN A1195 ( 4.6A) MN A1194 (-3.9A)None | 1.08A | 3k4vC-3zt9A:undetectable | 3k4vC-3zt9A:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 4 | GLY A 511ASP A 283GLY A 503THR A 185 | None MG A1770 ( 2.7A) K A1772 ( 4.5A)None | 1.05A | 3k4vC-4a01A:undetectable | 3k4vC-4a01A:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4af1 | PEPTIDE CHAINRELEASE FACTORSUBUNIT 1 (Halobacteriumsalinarum) |
PF03463(eRF1_1)PF03464(eRF1_2)PF03465(eRF1_3) | 4 | GLY A 106ASP A 102GLY A 31THR A 69 | None | 1.08A | 3k4vC-4af1A:undetectable | 3k4vC-4af1A:13.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b62 | TSSL1 (Pseudomonasaeruginosa) |
PF00691(OmpA) | 4 | GLY A 432ASP A 376GLY A 336THR A 333 | None | 0.91A | 3k4vC-4b62A:undetectable | 3k4vC-4b62A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f82 | THIOREDOXINREDUCTASE (Burkholderiacenocepacia) |
PF08534(Redoxin) | 4 | GLY A 74ASP A 76GLY A 140THR A 145 | None | 1.04A | 3k4vC-4f82A:undetectable | 3k4vC-4f82A:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fr2 | 1,3-PROPANEDIOLDEHYDROGENASE (Oenococcus oeni) |
PF00465(Fe-ADH) | 4 | GLY A 108ASP A 106GLY A 147THR A 142 | None | 1.01A | 3k4vC-4fr2A:undetectable | 3k4vC-4fr2A:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvt | POST-PROLINECLEAVING ENZYME (Rickettsiatyphi) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 4 | GLY A 683ASP A 649GLY A 657THR A 43 | None | 0.69A | 3k4vC-4hvtA:undetectable | 3k4vC-4hvtA:10.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ici | PUTATIVEFLAVOPROTEIN (Bacteroideseggerthii) |
PF12682(Flavodoxin_4) | 4 | GLY A 151ASP A 119GLY A 146THR A 46 | NoneNoneFMN A 200 (-3.3A)FMN A 200 (-3.6A) | 0.77A | 3k4vC-4iciA:undetectable | 3k4vC-4iciA:27.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ilk | STARVATION SENSINGPROTEIN RSPB (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | GLY A 259ASP A 234GLY A 168THR A 175 | NoneNoneNAI A 401 (-3.5A)None | 1.07A | 3k4vC-4ilkA:undetectable | 3k4vC-4ilkA:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jx6 | PYRUVATE CARBOXYLASE (Rhizobium etli) |
PF00682(HMGL-like)PF02436(PYC_OADA) | 4 | GLY A 766ASP A 768GLY A 741THR A 701 | None MG A1103 (-3.3A)NoneNone | 1.09A | 3k4vC-4jx6A:undetectable | 3k4vC-4jx6A:10.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kjd | INTESTINAL-TYPEALKALINE PHOSPHATASE1 (Rattusnorvegicus) |
PF00245(Alk_phosphatase) | 4 | GLY A 318ASP A 316GLY A 41THR A 147 | None | 1.04A | 3k4vC-4kjdA:undetectable | 3k4vC-4kjdA:13.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m0m | PUTATIVEUNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 4 | GLY A 178ASP A 182GLY A 109THR A 23 | None | 1.04A | 3k4vC-4m0mA:undetectable | 3k4vC-4m0mA:9.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0i | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01425(Amidase) | 4 | GLY A 190ASP A 150GLY A 428THR A 215 | NoneGLN A 501 ( 4.7A)NoneNone | 1.02A | 3k4vC-4n0iA:undetectable | 3k4vC-4n0iA:11.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | RIT A 500 (-3.9A)RIT A 500 (-3.2A)RIT A 500 (-4.8A)None | 0.33A | 3k4vC-4njvA:20.5 | 3k4vC-4njvA:84.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o8u | UNCHARACTERIZEDPROTEIN PF2046 (Pyrococcusfuriosus) |
PF13680(DUF4152) | 4 | GLY A 62ASP A 59GLY A 29THR A 33 | None | 0.86A | 3k4vC-4o8uA:undetectable | 3k4vC-4o8uA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q05 | ESTERASE E25 (unculturedbacterium) |
PF07859(Abhydrolase_3) | 4 | GLY A 313ASP A 282GLY A 309THR A 41 | None | 1.06A | 3k4vC-4q05A:undetectable | 3k4vC-4q05A:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpw | GLYCOSYL HYDROLASEFAMILY 10 (Bacteroidesintestinalis) |
no annotation | 4 | GLY A 196ASP A 193GLY A 190THR A 289 | None | 0.94A | 3k4vC-4qpwA:undetectable | 3k4vC-4qpwA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qsl | PYRUVATE CARBOXYLASE (Listeriamonocytogenes) |
no annotation | 4 | GLY H 758ASP H 760GLY H 708THR H 740 | None | 1.02A | 3k4vC-4qslH:undetectable | 3k4vC-4qslH:6.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r2b | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Ochrobactrumanthropi) |
PF01547(SBP_bac_1) | 4 | GLY A 69ASP A 251GLY A 191THR A 198 | None | 0.63A | 3k4vC-4r2bA:undetectable | 3k4vC-4r2bA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rpa | PROBABLEMANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Staphylococcusaureus) |
PF01368(DHH)PF02833(DHHA2) | 4 | GLY A 275ASP A 272GLY A 268THR A 214 | None | 0.96A | 3k4vC-4rpaA:undetectable | 3k4vC-4rpaA:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkx | LYS-GINGIPAIN W83 (Porphyromonasgingivalis) |
PF01364(Peptidase_C25)PF03785(Peptidase_C25_C) | 4 | GLY L 474ASP L 516GLY L 560THR L 544 | NoneTCK L 720 (-3.0A)NoneNone | 1.02A | 3k4vC-4tkxL:undetectable | 3k4vC-4tkxL:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u48 | PUTATIVE INNERMEMBRANE LIPOPROTEIN (Salmonellaenterica) |
PF00207(A2M)PF01835(A2M_N)PF07703(A2M_N_2)PF10569(Thiol-ester_cl)PF11974(MG1) | 4 | GLY A 925ASP A 922GLY A 285THR A 280 | None | 0.92A | 3k4vC-4u48A:undetectable | 3k4vC-4u48A:4.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u5x | RAC-LIKE GTP-BINDINGPROTEIN 1 (Oryza sativa) |
PF00071(Ras) | 4 | GLY A 81ASP A 83GLY A 61THR A 65 | NoneGOL A 204 (-3.4A)NoneNone | 0.90A | 3k4vC-4u5xA:undetectable | 3k4vC-4u5xA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uir | OLEATE HYDRATASE (Elizabethkingiameningoseptica) |
PF06100(MCRA) | 4 | GLY A 251ASP A 254GLY A 422THR A 225 | NA A1648 ( 4.6A) NA A1648 ( 3.8A)NoneNone | 1.08A | 3k4vC-4uirA:undetectable | 3k4vC-4uirA:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzs | BETA-GALACTOSIDASE (Bifidobacteriumbifidum) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 4 | GLY A 525ASP A 522GLY A 518THR A 502 | POL A 707 (-3.7A)POL A 707 ( 4.7A)NoneNone | 0.99A | 3k4vC-4uzsA:undetectable | 3k4vC-4uzsA:9.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6v | DI-/TRIPEPTIDETRANSPORTER (Yersiniaenterocolitica) |
PF00854(PTR2) | 4 | GLY A 88ASP A 84GLY A 79THR A 236 | None | 0.91A | 3k4vC-4w6vA:undetectable | 3k4vC-4w6vA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wqe | THIOSULFATEDEHYDROGENASE (Allochromatiumvinosum) |
PF13442(Cytochrome_CBB3) | 4 | GLY A 165ASP A 167GLY A 185THR A 231 | NoneNoneIOD A1004 ( 4.5A)None | 1.04A | 3k4vC-4wqeA:undetectable | 3k4vC-4wqeA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeu | TRANSKETOLASE (Pseudomonasaeruginosa) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | GLY A 28ASP A 183GLY A 156THR A 113 | None | 1.05A | 3k4vC-4xeuA:undetectable | 3k4vC-4xeuA:8.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | None | 0.54A | 3k4vC-5b18A:18.1 | 3k4vC-5b18A:73.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Geobactersulfurreducens) |
PF13847(Methyltransf_31) | 4 | GLY A 98ASP A 95GLY A 45THR A 64 | NoneSAH A 301 (-3.3A)SAH A 301 (-3.6A)None | 0.66A | 3k4vC-5bp7A:undetectable | 3k4vC-5bp7A:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czv | NEUROGENIC LOCUSNOTCH HOMOLOGPROTEIN 3 (Homo sapiens) |
PF00066(Notch)PF06816(NOD)PF07684(NODP) | 4 | GLY A1422ASP A1609GLY A1631THR A1516 | None | 1.06A | 3k4vC-5czvA:undetectable | 3k4vC-5czvA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dvj | BINDING PROTEINCOMPONENT OF ABCSUGAR TRANSPORTER (Pseudomonasputida) |
PF01547(SBP_bac_1) | 4 | GLY A 66ASP A 249GLY A 188THR A 195 | None | 0.57A | 3k4vC-5dvjA:undetectable | 3k4vC-5dvjA:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 4 | GLY A 97ASP A 94GLY A 44THR A 63 | NoneSAH A 301 (-3.5A)SAH A 301 (-3.6A)None | 0.64A | 3k4vC-5epeA:undetectable | 3k4vC-5epeA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g3z | ADENYLATE KINSE (syntheticconstruct) |
PF00406(ADK)PF05191(ADK_lid) | 4 | GLY A 32ASP A 84GLY A 7THR A 89 | AP5 A1217 (-3.6A) MG A1218 ( 4.4A)NoneNone | 0.90A | 3k4vC-5g3zA:undetectable | 3k4vC-5g3zA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hql | RIBULOSEBISPHOSPHATECARBOXYLASE (Rhodopseudomonaspalustris) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 4 | GLY A 163ASP A 189GLY A 159THR A 365 | None | 1.04A | 3k4vC-5hqlA:undetectable | 3k4vC-5hqlA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jrj | PROTEIN RECA (Herbaspirillumseropedicae) |
PF00154(RecA) | 4 | GLY A 279ASP A 268GLY A 274THR A 49 | None | 1.08A | 3k4vC-5jrjA:undetectable | 3k4vC-5jrjA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzt | PEPTIDE/NICKELTRANSPORT SYSTEMSUBSTRATE-BINDINGPROTEIN (Listeriamonocytogenes) |
PF00496(SBP_bac_5) | 4 | GLY A 456ASP A 548GLY A 68THR A 195 | None | 1.10A | 3k4vC-5kztA:undetectable | 3k4vC-5kztA:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lki | TCDA1 (Photorhabdusluminescens) |
PF03538(VRP1) | 4 | GLY A2453ASP A2428GLY A2424THR A2503 | None | 1.05A | 3k4vC-5lkiA:undetectable | 3k4vC-5lkiA:3.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nit | GLUCOSE OXIDASE (Aspergillusniger) |
no annotation | 4 | GLY A 346ASP A 416GLY A 108THR A 112 | NoneDIO A 618 (-3.8A)FAD A 601 (-3.3A)None | 1.10A | 3k4vC-5nitA:undetectable | 3k4vC-5nitA:10.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5twt | PEROXIDASE PVI9 (Panicumvirgatum) |
PF00141(peroxidase) | 4 | GLY A 111ASP A 219GLY A 165THR A 264 | None CA A 302 (-2.9A)NoneNone | 1.10A | 3k4vC-5twtA:undetectable | 3k4vC-5twtA:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u84 | ACID CERAMIDASE (Balaenopteraacutorostrata) |
no annotation | 4 | GLY A 379ASP A 375GLY A 284THR A 212 | NoneI3C A 407 (-3.3A)NoneNone | 1.03A | 3k4vC-5u84A:undetectable | 3k4vC-5u84A:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf4 | UNCHARACTERIZEDPROTEIN (Thermusaquaticus) |
PF03781(FGE-sulfatase) | 4 | GLY A 137ASP A 193GLY A 190THR A 124 | None | 0.89A | 3k4vC-5vf4A:undetectable | 3k4vC-5vf4A:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xge | UNCHARACTERIZEDPROTEIN PA0861 (Pseudomonasaeruginosa) |
no annotation | 4 | GLY A 442ASP A 447GLY A 458THR A 380 | None | 1.07A | 3k4vC-5xgeA:undetectable | 3k4vC-5xgeA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xts | MACROPHAGE MANNOSERECEPTOR 1 (Homo sapiens) |
no annotation | 4 | GLY A 415ASP A 420GLY A 483THR A 399 | None | 1.00A | 3k4vC-5xtsA:undetectable | 3k4vC-5xtsA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6frl | TRYPTOPHANHALOGENASESUPERFAMILY (Brevundimonassp. BAL3) |
no annotation | 4 | GLY A 230ASP A 220GLY A 339THR A 384 | NoneNoneTLA A 601 (-3.5A)None | 1.10A | 3k4vC-6frlA:undetectable | 3k4vC-6frlA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyd | PUTATIVEFAD-DEPENDENTOXYGENASE ENCM (Streptomycesmaritimus) |
no annotation | 4 | GLY A 149ASP A 162GLY A 360THR A 245 | FAD A 600 (-3.6A)NoneNoneNone | 1.06A | 3k4vC-6fydA:undetectable | 3k4vC-6fydA:17.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 4 | GLY A 27ASP A 29GLY A 48THR A 80 | NIU A 100 (-4.5A)NoneNoneNone | 0.51A | 3k4vC-6upjA:18.1 | 3k4vC-6upjA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czi | CHYMOSIN (Bos taurus) |
PF00026(Asp) | 5 | LEU E 30ASP E 32GLY E 34ASP E 37ILE E 120 | None | 0.57A | 3k4vD-1cziE:6.9 | 3k4vD-1cziE:17.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 12 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 4.9A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.51A | 3k4vD-1hvcA:13.8 | 3k4vD-1hvcA:46.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 12 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 4.7A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.41A | 3k4vD-1hvcA:13.8 | 3k4vD-1hvcA:46.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyl | HYPODERMA LINEATUMCOLLAGENASE (Hypodermalineatum) |
PF00089(Trypsin) | 5 | LEU A 209ALA A 136GLY A 183VAL A 231ILE A 210 | None | 0.93A | 3k4vD-1hylA:undetectable | 3k4vD-1hylA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j9l | STATIONARY PHASESURVIVAL PROTEIN (Thermotogamaritima) |
PF01975(SurE) | 5 | LEU A 4GLY A 112ALA A 113VAL A 87ILE A 90 | None | 0.96A | 3k4vD-1j9lA:undetectable | 3k4vD-1j9lA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kpl | PUTATIVE CLC FAMILY,CHLORINE TRANSPORTPROTEIN (Salmonellaenterica) |
PF00654(Voltage_CLC) | 5 | GLY A 181ALA A 182ILE A 109PRO A 206ILE A 200 | None | 0.97A | 3k4vD-1kplA:undetectable | 3k4vD-1kplA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 5 | GLY A 721ALA A 720GLY A 715ILE A 714ILE A 707 | None | 0.86A | 3k4vD-1l5jA:undetectable | 3k4vD-1l5jA:9.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 84 | None | 0.59A | 3k4vD-1q9pA:10.0 | 3k4vD-1q9pA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 5 | GLY A 27ALA A 28ASP A 29PRO A 81ILE A 84 | None | 0.80A | 3k4vD-1q9pA:10.0 | 3k4vD-1q9pA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhg | ATP-DEPENDENTHELICASE PCRA (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | LEU A 638ALA A 604ILE A 300ILE A 292PRO A 642 | None | 0.87A | 3k4vD-1qhgA:undetectable | 3k4vD-1qhgA:9.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhh | PROTEIN (PCRA(SUBUNIT)) (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | LEU D 638ALA D 604ILE B 300ILE B 292PRO D 642 | None | 0.87A | 3k4vD-1qhhD:undetectable | 3k4vD-1qhhD:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qho | ALPHA-AMYLASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | LEU A 71GLY A 53ASP A 21VAL A 74ILE A 16 | NoneNone CA A 698 (-3.2A)NoneNone | 0.96A | 3k4vD-1qhoA:undetectable | 3k4vD-1qhoA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1shz | GUANINENUCLEOTIDE-BINDINGPROTEINGALPHA(13):GALPHA(I1) CHIMERA (Mus musculus;Rattusnorvegicus) |
PF00503(G-alpha) | 5 | LEU A 152ASP A 155GLY A 111VAL A 100ILE A 158 | None | 0.97A | 3k4vD-1shzA:undetectable | 3k4vD-1shzA:14.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 10 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.48A | 3k4vD-1sivA:18.1 | 3k4vD-1sivA:51.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tcs | TRICHOSANTHIN (Trichosantheskirilowii) |
PF00161(RIP) | 5 | LEU A 215GLY A 231ALA A 230VAL A 213ILE A 225 | None | 0.96A | 3k4vD-1tcsA:undetectable | 3k4vD-1tcsA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w3f | HEMOLYTIC LECTINFROM LAETIPORUSSULPHUREUS (Laetiporussulphureus) |
PF03318(ETX_MTX2) | 5 | GLY A 241GLY A 296ILE A 297PRO A 221VAL A 220 | None | 0.99A | 3k4vD-1w3fA:undetectable | 3k4vD-1w3fA:15.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cda | GLUCOSEDEHYDROGENASE (Sulfolobussolfataricus) |
PF08240(ADH_N)PF16912(Glu_dehyd_C) | 5 | LEU A 261GLY A 255ALA A 256VAL A 264ILE A 260 | NoneNAP A1367 (-3.3A)NAP A1367 (-3.3A)NoneNAP A1367 ( 4.5A) | 0.96A | 3k4vD-2cdaA:undetectable | 3k4vD-2cdaA:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dup | VESICULARINTEGRAL-MEMBRANEPROTEIN VIP36 (Canis lupus) |
PF03388(Lectin_leg-like) | 5 | LEU A 224GLY A 201ALA A 200VAL A 245ILE A 242 | None | 0.98A | 3k4vD-2dupA:undetectable | 3k4vD-2dupA:18.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 10 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ILE A 53GLY A 55PRO A 86VAL A 87ILE A 89 | NoneLP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 ( 4.9A)LP1 A 201 (-4.2A) | 0.55A | 3k4vD-2fmbA:14.9 | 3k4vD-2fmbA:33.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | GLY A 190ALA A 189GLY A 183ILE A 180PRO A 296 | NoneNonePLP A 400 (-3.4A)PLP A 400 (-4.9A)PLP A 400 (-4.0A) | 0.76A | 3k4vD-2isqA:undetectable | 3k4vD-2isqA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4z | METAL-DEPENDENTHYDROLASES OF THEBETA-LACTAMASESUPERFAMILY II (Caldanaerobactersubterraneus) |
PF00753(Lactamase_B) | 5 | LEU A 38GLY A 145ILE A 149VAL A 47ILE A 45 | None | 0.96A | 3k4vD-2p4zA:undetectable | 3k4vD-2p4zA:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjr | PROTEIN (HELICASEPCRA) (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | LEU B 638ALA B 604ILE A 300ILE A 292PRO B 642 | None | 0.96A | 3k4vD-2pjrB:undetectable | 3k4vD-2pjrB:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ri6 | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE (Paraburkholderiaxenovorans) |
PF12697(Abhydrolase_6) | 5 | LEU A 283ALA A 62GLY A 57VAL A 279ILE A 280 | None | 0.97A | 3k4vD-2ri6A:undetectable | 3k4vD-2ri6A:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ri6 | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE (Paraburkholderiaxenovorans) |
PF12697(Abhydrolase_6) | 5 | LEU A 283GLY A 63ALA A 62VAL A 279ILE A 280 | None | 0.85A | 3k4vD-2ri6A:undetectable | 3k4vD-2ri6A:16.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50ILE A 84 | NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.8A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 ( 4.2A) | 0.44A | 3k4vD-2rkfA:20.3 | 3k4vD-2rkfA:82.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 50PRO A 81ILE A 84 | NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.8A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.44A | 3k4vD-2rkfA:20.3 | 3k4vD-2rkfA:82.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rsp | RSV PROTEASE (Rous sarcomavirus) |
PF00077(RVP) | 6 | LEU A 35ASP A 37GLY A 39ALA A 40ASP A 41ILE A 108 | None | 0.43A | 3k4vD-2rspA:12.5 | 3k4vD-2rspA:33.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uv8 | FATTY ACID SYNTHASESUBUNIT BETA (FAS1) (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF01575(MaoC_dehydratas)PF08354(DUF1729)PF13452(MaoC_dehydrat_N)PF16073(SAT) | 5 | GLY G 621ALA G 620ILE G 617GLY G 648ILE G 676 | NoneFMN G3051 ( 4.7A)NoneNoneNone | 0.93A | 3k4vD-2uv8G:undetectable | 3k4vD-2uv8G:4.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASEIRON-SULFURATP-BINDING PROTEINLIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Prochlorococcusmarinus) |
PF00142(Fer4_NifH)PF00148(Oxidored_nitro) | 5 | LEU A 87ALA C 71GLY A 125VAL A 83ILE A 84 | NoneNoneSF4 A1302 (-4.1A)NoneEPE A1298 (-4.9A) | 0.94A | 3k4vD-2ynmA:undetectable | 3k4vD-2ynmA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbg | PUTATIVE CYTOCHROMEP450 (Streptomycescoelicolor) |
PF00067(p450) | 5 | GLY A 359ALA A 360ASP A 361PRO A 24ILE A 356 | None | 0.90A | 3k4vD-3dbgA:undetectable | 3k4vD-3dbgA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbs | OXIDOREDUCTASE (Agrobacteriumfabrum) |
PF07992(Pyr_redox_2) | 5 | GLY A 284ALA A 17ILE A 66GLY A 22ILE A 7 | None | 0.83A | 3k4vD-3fbsA:undetectable | 3k4vD-3fbsA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fs2 | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE (Brucellamelitensis) |
PF00793(DAHP_synth_1) | 5 | GLY A 75ASP A 61ILE A 98PRO A 109VAL A 110 | None | 0.80A | 3k4vD-3fs2A:undetectable | 3k4vD-3fs2A:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gh8 | IODOTYROSINEDEHALOGENASE 1 (Mus musculus) |
PF00881(Nitroreductase) | 5 | LEU A 256GLY A 218ILE A 116GLY A 120ILE A 190 | None | 0.81A | 3k4vD-3gh8A:undetectable | 3k4vD-3gh8A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gve | YFKN PROTEIN (Bacillussubtilis) |
PF00149(Metallophos) | 5 | GLY A 121ALA A 122ASP A 123ILE A 89ILE A 126 | None | 0.77A | 3k4vD-3gveA:undetectable | 3k4vD-3gveA:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hh1 | TETRAPYRROLEMETHYLASE FAMILYPROTEIN (Chlorobaculumtepidum) |
PF00590(TP_methylase) | 5 | LEU A 79GLY A 111ALA A 110VAL A 75ILE A 76 | None | 0.90A | 3k4vD-3hh1A:undetectable | 3k4vD-3hh1A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn6 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Borreliellaburgdorferi) |
PF01182(Glucosamine_iso) | 5 | GLY A 139ILE A 193GLY A 136ILE A 202ILE A 226 | None | 0.92A | 3k4vD-3hn6A:undetectable | 3k4vD-3hn6A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5g | MYOSIN HEAVY CHAINISOFORM A (Doryteuthispealeii) |
PF00063(Myosin_head)PF00612(IQ)PF02736(Myosin_N) | 5 | ALA A 265ASP A 266GLY A 460ILE A 459ILE A 224 | None | 0.99A | 3k4vD-3i5gA:undetectable | 3k4vD-3i5gA:8.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv7 | ADH-A (Rhodococcusruber) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 211GLY A 216ALA A 217ASP A 218ILE A 190 | None | 0.73A | 3k4vD-3jv7A:undetectable | 3k4vD-3jv7A:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kiz | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Cytophagahutchinsonii) |
PF02769(AIRS_C) | 5 | GLY A 59ASP A 161ILE A 108VAL A 77ILE A 81 | EDO A 398 ( 3.8A)NoneACT A 394 ( 4.6A)NoneNone | 0.88A | 3k4vD-3kizA:undetectable | 3k4vD-3kizA:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxd | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE (Novosphingobiumaromaticivorans) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 5 | LEU A 301ALA A 294ASP A 295GLY A 348ILE A 299 | None | 0.96A | 3k4vD-3lxdA:undetectable | 3k4vD-3lxdA:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdo | PUTATIVEPHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Parabacteroidesdistasonis) |
PF02769(AIRS_C) | 5 | GLY A 58ASP A 160ILE A 107VAL A 76ILE A 80 | NoneNoneACT A 395 (-4.3A)NoneNone | 0.90A | 3k4vD-3mdoA:undetectable | 3k4vD-3mdoA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdo | PUTATIVEPHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Parabacteroidesdistasonis) |
PF02769(AIRS_C) | 5 | LEU A 251ALA A 255ASP A 246ILE A 319ILE A 248 | None | 0.94A | 3k4vD-3mdoA:undetectable | 3k4vD-3mdoA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdo | PUTATIVEPHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Parabacteroidesdistasonis) |
PF02769(AIRS_C) | 5 | LEU A 251GLY A 256ALA A 255ILE A 319ILE A 248 | None | 0.97A | 3k4vD-3mdoA:undetectable | 3k4vD-3mdoA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwc | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Kosmotogaolearia) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 310ALA A 336ASP A 337VAL A 363ILE A 149 | None | 0.99A | 3k4vD-3mwcA:undetectable | 3k4vD-3mwcA:15.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ALA A 28ASP A 29GLY A 49ILE A 50 | None | 1.31A | 3k4vD-3mwsA:19.5 | 3k4vD-3mwsA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30PRO A 81VAL A 82ILE A 84 | None | 0.59A | 3k4vD-3mwsA:19.5 | 3k4vD-3mwsA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | None | 0.45A | 3k4vD-3mwsA:19.5 | 3k4vD-3mwsA:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogz | UDP-SUGARPYROPHOSPHORYLASE (Leishmaniamajor) |
PF01704(UDPGP) | 5 | GLY A 122ALA A 121ASP A 271ILE A 269ILE A 167 | None | 0.91A | 3k4vD-3ogzA:undetectable | 3k4vD-3ogzA:10.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slz | GAG-PRO-POLPOLYPROTEIN (Murine leukemiavirus) |
PF00077(RVP) | 5 | LEU A 30ASP A 32GLY A 34ALA A 35GLY A 56 | None3TL A 126 (-2.4A)3TL A 126 (-3.1A)3TL A 126 ( 4.0A)3TL A 126 (-3.4A) | 0.34A | 3k4vD-3slzA:11.1 | 3k4vD-3slzA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t2y | SULFIDE-QUINONEREDUCTASE, PUTATIVE (Acidithiobacillusferrooxidans) |
PF07992(Pyr_redox_2) | 5 | LEU A 7GLY A 106ALA A 303GLY A 281ILE A 103 | FAD A 500 (-4.7A)FAD A 500 (-3.1A)NoneNoneNone | 0.67A | 3k4vD-3t2yA:undetectable | 3k4vD-3t2yA:12.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 47GLY A 49ILE A 50 | SO4 A 101 (-4.2A)017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-3.5A)017 A 201 (-4.2A)None017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.47A | 3k4vD-3t3cA:18.1 | 3k4vD-3t3cA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 29ASP A 30ILE A 47GLY A 49PRO A 81 | SO4 A 101 (-4.2A)017 A 201 (-3.5A)017 A 201 (-4.2A)None017 A 201 (-4.0A)None | 0.89A | 3k4vD-3t3cA:18.1 | 3k4vD-3t3cA:74.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tl2 | MALATE DEHYDROGENASE (Bacillusanthracis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | LEU A 40ASP A 36GLY A 12ILE A 85ILE A 37 | NoneEDO A 315 (-3.3A)EDO A 315 ( 4.1A)NoneNone | 0.84A | 3k4vD-3tl2A:undetectable | 3k4vD-3tl2A:16.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 50ILE A 84 | None017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-4.6A)017 A 201 (-3.3A)017 A 201 (-4.7A) | 0.47A | 3k4vD-3ttpA:19.1 | 3k4vD-3ttpA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30PRO A 81ILE A 84 | None017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-4.6A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.45A | 3k4vD-3ttpA:19.1 | 3k4vD-3ttpA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29GLY A 49ILE A 50ILE A 84 | None017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.7A) | 0.43A | 3k4vD-3ttpA:19.1 | 3k4vD-3ttpA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29GLY A 49PRO A 81ILE A 84 | None017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-3.0A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.41A | 3k4vD-3ttpA:19.1 | 3k4vD-3ttpA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50 | None017 A 202 ( 2.5A)017 A 201 (-3.4A)017 A 201 ( 4.0A)017 A 202 (-2.9A)017 A 201 ( 3.5A) | 1.29A | 3k4vD-3u7sA:19.5 | 3k4vD-3u7sA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50 | None017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 201 (-3.2A)017 A 201 ( 4.0A)017 A 202 (-2.9A)017 A 201 ( 3.5A) | 0.37A | 3k4vD-3u7sA:19.5 | 3k4vD-3u7sA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 47GLY A 49PRO A 81 | None017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 201 (-3.2A)017 A 201 ( 4.0A)017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 202 (-4.0A) | 0.58A | 3k4vD-3u7sA:19.5 | 3k4vD-3u7sA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29VAL A 82 | None | 0.25A | 3k4vD-3uhlA:16.0 | 3k4vD-3uhlA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c30 | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | ALA A 180GLY A 130ILE A 135VAL A 143ILE A 144 | None | 0.96A | 3k4vD-4c30A:undetectable | 3k4vD-4c30A:9.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g09 | HISTIDINOLDEHYDROGENASE (Brucella suis) |
PF00815(Histidinol_dh) | 6 | LEU A 240ALA A 243ASP A 244GLY A 352ILE A 351ILE A 241 | None | 1.32A | 3k4vD-4g09A:undetectable | 3k4vD-4g09A:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hkm | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Xanthomonascampestris) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | ALA A 60ILE A 18GLY A 55ILE A 54ILE A 178 | None | 0.85A | 3k4vD-4hkmA:undetectable | 3k4vD-4hkmA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ida | RIPENING-INDUCEDPROTEIN (Fragaria vesca) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 5 | LEU A 203GLY A 208ALA A 209ASP A 210ILE A 179 | None | 0.94A | 3k4vD-4idaA:undetectable | 3k4vD-4idaA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inj | LMO1638 PROTEIN (Listeriamonocytogenes) |
PF02016(Peptidase_S66) | 5 | LEU A 162ALA A 309GLY A 306ILE A 305ILE A 321 | None | 0.95A | 3k4vD-4injA:undetectable | 3k4vD-4injA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k5u | VARIABLE LYMPHOCYTERECEPTOR (Petromyzonmarinus) |
no annotation | 5 | GLY B 63GLY B 18PRO B 25VAL B 24ILE B 42 | None | 0.73A | 3k4vD-4k5uB:undetectable | 3k4vD-4k5uB:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpg | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | LEU A 72GLY A 342GLY A 133PRO A 66ILE A 74 | None | 0.95A | 3k4vD-4kpgA:undetectable | 3k4vD-4kpgA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kt1 | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 4 (Homo sapiens) |
PF01462(LRRNT)PF13516(LRR_6)PF13855(LRR_8) | 5 | GLY A 90GLY A 45PRO A 52VAL A 51ILE A 69 | None | 0.87A | 3k4vD-4kt1A:undetectable | 3k4vD-4kt1A:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lom | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (Mycobacteriumtuberculosis) |
PF00475(IGPD) | 5 | LEU A 165GLY A 84ALA A 161VAL A 116ILE A 163 | None | 0.91A | 3k4vD-4lomA:undetectable | 3k4vD-4lomA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m1z | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | LEU A 72GLY A 342GLY A 133PRO A 66ILE A 74 | None | 0.93A | 3k4vD-4m1zA:undetectable | 3k4vD-4m1zA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mes | THIAMINE TRANSPORTERTHIT (Lactococcuslactis) |
PF09515(Thia_YuaJ) | 5 | LEU A 45ALA A 21ILE A 62GLY A 64ILE A 44 | None | 0.88A | 3k4vD-4mesA:undetectable | 3k4vD-4mesA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ml9 | UNCHARACTERIZEDPROTEIN (Sebaldellatermitidis) |
PF00977(His_biosynth) | 5 | GLY A 132ALA A 133ASP A 134PRO A 109ILE A 128 | None | 0.97A | 3k4vD-4ml9A:undetectable | 3k4vD-4ml9A:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4na3 | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 180GLY A 201ALA A 200ILE A 12ILE A 183 | None | 0.95A | 3k4vD-4na3A:undetectable | 3k4vD-4na3A:11.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 29ASP A 30GLY A 48PRO A 81ILE A 84 | RIT A 500 (-3.2A)RIT A 500 (-4.8A)RIT A 500 (-4.8A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.94A | 3k4vD-4njvA:20.3 | 3k4vD-4njvA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30PRO A 81ILE A 84 | NoneRIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-3.6A)RIT A 500 (-3.2A)RIT A 500 (-4.8A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.50A | 3k4vD-4njvA:20.3 | 3k4vD-4njvA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | NoneRIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-3.6A)RIT A 500 (-3.2A)RIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.42A | 3k4vD-4njvA:20.3 | 3k4vD-4njvA:84.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4phb | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF14262(Cthe_2159) | 5 | LEU A 56GLY A 69ILE A 111VAL A 63ILE A 65 | None | 1.00A | 3k4vD-4phbA:undetectable | 3k4vD-4phbA:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q00 | FERROUS IRONTRANSPORT PROTEIN B (Escherichiacoli) |
PF02421(FeoB_N) | 5 | LEU A 111GLY A 84ASP A 87GLY A 7ILE A 113 | None | 0.94A | 3k4vD-4q00A:undetectable | 3k4vD-4q00A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qxe | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 4, LINKER,VARIABLE LYMPHOCYTERECEPTOR B (Eptatretusburgeri;Homo sapiens) |
PF01462(LRRNT)PF11921(DUF3439)PF13516(LRR_6)PF13855(LRR_8) | 5 | GLY A 90GLY A 45PRO A 52VAL A 51ILE A 69 | None | 0.92A | 3k4vD-4qxeA:undetectable | 3k4vD-4qxeA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qxf | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 4, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF01462(LRRNT)PF11921(DUF3439)PF13855(LRR_8) | 5 | GLY A 90GLY A 45PRO A 52VAL A 51ILE A 69 | None | 0.85A | 3k4vD-4qxfA:undetectable | 3k4vD-4qxfA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rhh | BETA-XYLOSIDASE (Geobacillusstearothermophilus) |
PF03512(Glyco_hydro_52) | 5 | GLY A 110ALA A 109ILE A 45ILE A 89ILE A 96 | None | 0.99A | 3k4vD-4rhhA:undetectable | 3k4vD-4rhhA:10.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 7 | LEU A 30ASP A 32GLY A 34ALA A 35ASP A 36GLY A 58ILE A 100 | None4B1 A 201 (-2.9A)4B1 A 201 ( 4.6A)4B1 A 201 (-3.6A)4B1 A 201 (-4.4A)4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.57A | 3k4vD-4ydfA:12.4 | 3k4vD-4ydfA:32.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 84 | None | 0.75A | 3k4vD-5b18A:17.9 | 3k4vD-5b18A:73.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5erb | POLYKETIDE SYNTHASE (Bacillusamyloliquefaciens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 187GLY A 208ALA A 207ILE A 14ILE A 190 | None | 0.99A | 3k4vD-5erbA:undetectable | 3k4vD-5erbA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fr8 | TONB-DEPENDENTSIDEROPHORE RECEPTOR (Acinetobacterbaumannii) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | LEU A 576GLY A 579ILE A 617PRO A 611ILE A 577 | None | 0.90A | 3k4vD-5fr8A:undetectable | 3k4vD-5fr8A:9.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k0y | EUKARYOTICINITIATION FACTOR 2GAMMA SUBUNIT(EIF2-GAMMA) (Oryctolaguscuniculus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 5 | GLY S 353ILE S 296GLY S 294VAL S 309ILE S 307 | A N 75 ( 4.3A)NoneNoneNoneNone | 0.98A | 3k4vD-5k0yS:undetectable | 3k4vD-5k0yS:12.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ALA A 28ASP A 29GLY A 49ILE A 50 | None | 1.32A | 3k4vD-5t2zA:19.7 | 3k4vD-5t2zA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 47GLY A 49ILE A 50ILE A 84 | None | 0.46A | 3k4vD-5t2zA:19.7 | 3k4vD-5t2zA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 47GLY A 49PRO A 81ILE A 84 | None | 0.50A | 3k4vD-5t2zA:19.7 | 3k4vD-5t2zA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ve3 | BPPRF (Paraburkholderiaphytofirmans) |
no annotation | 5 | GLY B 88ALA B 89ASP B 90VAL B 59ILE B 80 | None | 0.90A | 3k4vD-5ve3B:undetectable | 3k4vD-5ve3B:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ve8 | KAP123 (Kluyveromyceslactis) |
no annotation | 5 | LEU A 871ALA A 886ILE A 845VAL A 867ILE A 868 | None | 0.99A | 3k4vD-5ve8A:undetectable | 3k4vD-5ve8A:7.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vm2 | ALCOHOLDEHYDROGENASE (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 237ALA A 238ASP A 239VAL A 199ILE A 173 | None | 0.81A | 3k4vD-5vm2A:undetectable | 3k4vD-5vm2A:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk7 | ELONGATION FACTOR G (Enterococcusfaecalis) |
no annotation | 5 | GLY A 22ALA A 21ASP A 20GLY A 84VAL A 103 | None | 0.99A | 3k4vD-6bk7A:undetectable | 3k4vD-6bk7A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bma | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Campylobacterjejuni) |
no annotation | 5 | ALA A 237ASP A 236ILE A 184GLY A 186ILE A 54 | None | 0.81A | 3k4vD-6bmaA:undetectable | 3k4vD-6bmaA:16.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 7 | LEU A 28ASP A 30GLY A 32ALA A 33ASP A 34GLY A 58VAL A 99 | None3TL A 201 (-3.5A)3TL A 201 (-3.4A)3TL A 201 (-4.0A)3TL A 201 (-3.9A)3TL A 201 (-3.4A)None | 0.50A | 3k4vD-6fivA:15.4 | 3k4vD-6fivA:30.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ALA A 28ASP A 30GLY A 49ILE A 84 | NoneNIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNIU A 100 ( 3.8A)None | 0.55A | 3k4vD-6upjA:17.7 | 3k4vD-6upjA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 8 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30PRO A 81ILE A 84 | NoneNIU A 100 (-2.8A)NIU A 100 (-4.5A)NIU A 100 (-3.6A)NoneNoneNoneNone | 0.52A | 3k4vD-6upjA:17.7 | 3k4vD-6upjA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | LEU A 23ASP A 30GLY A 49ILE A 50ILE A 84 | NoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)None | 0.90A | 3k4vD-6upjA:17.7 | 3k4vD-6upjA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | LEU A 23GLY A 27ASP A 29ASP A 30ILE A 50PRO A 81ILE A 84 | NoneNIU A 100 (-4.5A)NoneNoneNIU A 100 (-3.9A)NoneNone | 0.69A | 3k4vD-6upjA:17.7 | 3k4vD-6upjA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1akm | ORNITHINETRANSCARBAMYLASE (Escherichiacoli) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | ARG A 246VAL A 255THR A 230 | None | 0.70A | 3k4vD-1akmA:0.0 | 3k4vD-1akmA:11.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bco | BACTERIOPHAGE MUTRANSPOSASE (Escherichiavirus Mu) |
PF02914(DDE_2)PF09299(Mu-transpos_C) | 3 | ARG A 324VAL A 467THR A 297 | None | 0.74A | 3k4vD-1bcoA:0.0 | 3k4vD-1bcoA:14.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fml | RETINOL DEHYDRATASE (Spodopterafrugiperda) |
PF00685(Sulfotransfer_1) | 3 | ARG A 185VAL A 68THR A 79 | A3P A 400 (-2.8A)NoneNone | 0.84A | 3k4vD-1fmlA:0.0 | 3k4vD-1fmlA:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fml | RETINOL DEHYDRATASE (Spodopterafrugiperda) |
PF00685(Sulfotransfer_1) | 3 | ARG A 312VAL A 293THR A 77 | A3P A 400 (-3.7A)NoneA3P A 400 (-3.6A) | 0.77A | 3k4vD-1fmlA:0.0 | 3k4vD-1fmlA:13.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ARG A 8VAL A 32THR A 80 | A79 A 800 (-3.4A)A79 A 800 ( 4.4A)None | 0.36A | 3k4vD-1hvcA:13.8 | 3k4vD-1hvcA:46.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ARG A 8VAL A 32THR A 80 | A79 A 800 (-3.6A)A79 A 800 ( 4.3A)None | 0.32A | 3k4vD-1hvcA:13.8 | 3k4vD-1hvcA:46.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mlz | 7,8-DIAMINO-PELARGONIC ACIDAMINOTRANSFERASE (Escherichiacoli) |
PF00202(Aminotran_3) | 3 | ARG A 221VAL A 154THR A 139 | None | 0.59A | 3k4vD-1mlzA:0.0 | 3k4vD-1mlzA:12.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n9b | BETA-LACTAMASE SHV-2 (Klebsiellapneumoniae) |
PF13354(Beta-lactamase2) | 3 | ARG A 266VAL A 247THR A 71 | None | 0.54A | 3k4vD-1n9bA:undetectable | 3k4vD-1n9bA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ort | ORNITHINETRANSCARBAMOYLASE (Pseudomonasaeruginosa) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | ARG A 246VAL A 255THR A 230 | None | 0.63A | 3k4vD-1ortA:undetectable | 3k4vD-1ortA:13.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlb | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Wolinellasuccinogenes) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 3 | ARG A 139VAL A 105THR A 159 | None | 0.84A | 3k4vD-1qlbA:0.0 | 3k4vD-1qlbA:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8t | HEPARAN SULFATED-GLUCOSAMINYL3-O-SULFOTRANSFERASE3A1 (Homo sapiens) |
PF00685(Sulfotransfer_1) | 3 | ARG A 248VAL A 379THR A 270 | None | 0.63A | 3k4vD-1t8tA:0.0 | 3k4vD-1t8tA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vj7 | BIFUNCTIONALRELA/SPOT (Streptococcusdysgalactiae) |
PF04607(RelA_SpoT)PF13328(HD_4) | 3 | ARG A 290VAL A 282THR A 313 | None | 0.75A | 3k4vD-1vj7A:undetectable | 3k4vD-1vj7A:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb5 | QUINONEOXIDOREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ARG A 12VAL A 73THR A 98 | None | 0.72A | 3k4vD-1yb5A:undetectable | 3k4vD-1yb5A:13.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9s | TOPOISOMERASE I-LIKEPROTEIN (Leishmaniadonovani) |
PF01028(Topoisom_I)PF02919(Topoisom_I_N) | 3 | ARG A 310VAL A 447THR A 417 | None | 0.83A | 3k4vD-2b9sA:undetectable | 3k4vD-2b9sA:13.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bru | NAD(P)TRANSHYDROGENASESUBUNIT BETA (Escherichiacoli) |
PF02233(PNTB) | 3 | ARG C 58VAL C 109THR C 106 | None | 0.81A | 3k4vD-2bruC:undetectable | 3k4vD-2bruC:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c5s | PROBABLE THIAMINEBIOSYNTHESIS PROTEINTHII (Bacillusanthracis) |
PF02568(ThiI)PF02926(THUMP) | 3 | ARG A 314VAL A 207THR A 272 | None | 0.69A | 3k4vD-2c5sA:undetectable | 3k4vD-2c5sA:11.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2col | BIFUNCTIONALHEMOLYSIN-ADENYLATECYCLASE (Bordetellapertussis) |
PF03497(Anthrax_toxA) | 3 | ARG A 15VAL A 43THR A 48 | None | 0.70A | 3k4vD-2colA:undetectable | 3k4vD-2colA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ek8 | AMINOPEPTIDASE (Aneurinibacillussp. AM-1) |
PF02225(PA)PF04389(Peptidase_M28) | 3 | ARG A 42VAL A 245THR A 268 | None | 0.83A | 3k4vD-2ek8A:undetectable | 3k4vD-2ek8A:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5t | DIPEPTIDYL PEPTIDASE4 (Homo sapiens) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 3 | ARG A 184VAL A 155THR A 152 | None | 0.76A | 3k4vD-2g5tA:undetectable | 3k4vD-2g5tA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gah | HETEROTETRAMERICSARCOSINE OXIDASEALPHA-SUBUNIT (Stenotrophomonasmaltophilia) |
PF01571(GCV_T)PF07992(Pyr_redox_2)PF08669(GCV_T_C)PF13510(Fer2_4) | 3 | ARG A 422VAL A 246THR A 435 | None | 0.79A | 3k4vD-2gahA:undetectable | 3k4vD-2gahA:7.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h7g | DNA TOPOISOMERASE 1 (Variola virus) |
PF01028(Topoisom_I)PF09266(VirDNA-topo-I_N) | 3 | ARG X 86VAL X 304THR X 278 | None | 0.81A | 3k4vD-2h7gX:undetectable | 3k4vD-2h7gX:13.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iht | CARBOXYETHYLARGININESYNTHASE (Streptomycesclavuligerus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | ARG A 229VAL A 62THR A 94 | None | 0.83A | 3k4vD-2ihtA:undetectable | 3k4vD-2ihtA:11.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lc0 | PUTATIVEUNCHARACTERIZEDPROTEIN TB39.8 (Mycobacteriumtuberculosis) |
PF12401(DUF3662) | 3 | ARG A 10VAL A 125THR A 100 | None | 0.74A | 3k4vD-2lc0A:undetectable | 3k4vD-2lc0A:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nwq | PROBABLE SHORT-CHAINDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00106(adh_short) | 3 | ARG A 80VAL A 52THR A 50 | None | 0.76A | 3k4vD-2nwqA:undetectable | 3k4vD-2nwqA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oap | TYPE II SECRETIONSYSTEM PROTEIN (Archaeoglobusfulgidus) |
PF00437(T2SSE) | 3 | ARG 1 409VAL 1 265THR 1 276 | None | 0.82A | 3k4vD-2oap1:undetectable | 3k4vD-2oap1:11.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2owm | RELATED TOKINESIN-LIKE PROTEINKIF1C (Neurosporacrassa) |
PF00225(Kinesin) | 3 | ARG A 294VAL A 40THR A 415 | None | 0.67A | 3k4vD-2owmA:undetectable | 3k4vD-2owmA:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0q | ARYL ESTERASE (Mycolicibacteriumsmegmatis) |
PF13472(Lipase_GDSL_2) | 3 | ARG A 33VAL A 19THR A 25 | GOL A1730 (-2.9A)NoneNone | 0.76A | 3k4vD-2q0qA:undetectable | 3k4vD-2q0qA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpq | PROTEIN BUG27 (Bordetellapertussis) |
PF03401(TctC) | 3 | ARG A 83VAL A 77THR A 293 | None | 0.83A | 3k4vD-2qpqA:undetectable | 3k4vD-2qpqA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqk | NEUROPILIN-2 (Homo sapiens) |
PF00431(CUB)PF00754(F5_F8_type_C) | 3 | ARG A 518VAL A 468THR A 367 | None | 0.82A | 3k4vD-2qqkA:undetectable | 3k4vD-2qqkA:11.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9g | AAA ATPASE, CENTRALREGION (Enterococcusfaecium) |
PF12002(MgsA_C) | 3 | ARG A 278VAL A 320THR A 298 | None | 0.72A | 3k4vD-2r9gA:undetectable | 3k4vD-2r9gA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvd | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 3 | ARG A 60VAL A 92THR A 112 | None | 0.74A | 3k4vD-2uvdA:undetectable | 3k4vD-2uvdA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w45 | ALKALINE EXONUCLEASE (Humangammaherpesvirus4) |
PF01771(Herpes_alk_exo) | 3 | ARG A 45VAL A 32THR A 454 | None | 0.78A | 3k4vD-2w45A:undetectable | 3k4vD-2w45A:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfq | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Peptoniphilusasaccharolyticus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | ARG A 187VAL A 73THR A 149 | SO4 A1423 (-2.1A)NoneNone | 0.80A | 3k4vD-2yfqA:undetectable | 3k4vD-2yfqA:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z61 | PROBABLE ASPARTATEAMINOTRANSFERASE 2 (Methanocaldococcusjannaschii) |
PF00155(Aminotran_1_2) | 3 | ARG A 230VAL A 48THR A 43 | LLP A 222 ( 2.8A)NoneNone | 0.70A | 3k4vD-2z61A:undetectable | 3k4vD-2z61A:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axs | PROBABLEN(2),N(2)-DIMETHYLGUANOSINE TRNAMETHYLTRANSFERASETRM1 (Aquifexaeolicus) |
PF02005(TRM) | 3 | ARG A 192VAL A 358THR A 355 | None | 0.84A | 3k4vD-3axsA:undetectable | 3k4vD-3axsA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ckb | SUSD (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB) | 3 | ARG A 294VAL A 303THR A 316 | None | 0.84A | 3k4vD-3ckbA:undetectable | 3k4vD-3ckbA:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cps | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Cryptosporidiumparvum) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | ARG A 252VAL A 261THR A 169 | None | 0.80A | 3k4vD-3cpsA:undetectable | 3k4vD-3cpsA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqc | DNA REPAIR PROTEINREV1 (Homo sapiens) |
PF00817(IMS)PF11799(IMS_C) | 3 | ARG A 595VAL A 549THR A 602 | None | 0.84A | 3k4vD-3gqcA:undetectable | 3k4vD-3gqcA:12.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grf | ORNITHINECARBAMOYLTRANSFERASE (Giardiaintestinalis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | ARG A 255VAL A 264THR A 239 | None | 0.78A | 3k4vD-3grfA:undetectable | 3k4vD-3grfA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gt5 | N-ACETYLGLUCOSAMINE2-EPIMERASE (Xylellafastidiosa) |
PF07221(GlcNAc_2-epim) | 3 | ARG A 204VAL A 125THR A 147 | None | 0.69A | 3k4vD-3gt5A:undetectable | 3k4vD-3gt5A:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in5 | DNA POLYMERASE KAPPA (Homo sapiens) |
PF00817(IMS)PF11798(IMS_HHH)PF11799(IMS_C) | 3 | ARG A 298VAL A 177THR A 305 | None | 0.80A | 3k4vD-3in5A:undetectable | 3k4vD-3in5A:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR SPP42 (Schizosaccharomycespombe) |
PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 3 | ARG A 94VAL A 519THR A 148 | None | 0.75A | 3k4vD-3jb9A:undetectable | 3k4vD-3jb9A:4.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6r | SERINE RACEMASE (Homo sapiens) |
PF00291(PALP) | 3 | ARG A 277VAL A 293THR A 38 | None | 0.79A | 3k4vD-3l6rA:undetectable | 3k4vD-3l6rA:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm6 | STAGE V SPORULATIONPROTEIN AD (Bacillussubtilis) |
PF07451(SpoVAD) | 3 | ARG A 295VAL A 284THR A 22 | None | 0.78A | 3k4vD-3lm6A:undetectable | 3k4vD-3lm6A:12.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mcu | DIPICOLINATESYNTHASE, B CHAIN (Bacillus cereus) |
PF02441(Flavoprotein) | 3 | ARG A 37VAL A 124THR A 117 | None | 0.63A | 3k4vD-3mcuA:undetectable | 3k4vD-3mcuA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdw | UNCHARACTERIZEDHYDROLASE YUTF (Bacillussubtilis) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 3 | ARG A 124VAL A 119THR A 147 | None | 0.83A | 3k4vD-3pdwA:undetectable | 3k4vD-3pdwA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r75 | ANTHRANILATE/PARA-AMINOBENZOATESYNTHASES COMPONENTI (Burkholderialata) |
PF00117(GATase)PF00425(Chorismate_bind) | 3 | ARG A 504VAL A 473THR A 457 | None | 0.79A | 3k4vD-3r75A:undetectable | 3k4vD-3r75A:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhy | N(G),N(G)-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE (Pseudomonasaeruginosa) |
PF02274(Amidinotransf) | 3 | ARG A 85VAL A 160THR A 165 | HM3 A 255 ( 4.7A)NoneNone | 0.71A | 3k4vD-3rhyA:undetectable | 3k4vD-3rhyA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 3 | ARG A 440VAL A 360THR A 34 | None | 0.50A | 3k4vD-3tsdA:undetectable | 3k4vD-3tsdA:13.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vi3 | INTEGRIN ALPHA-5 (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 3 | ARG A 423VAL A 369THR A 292 | None | 0.81A | 3k4vD-3vi3A:undetectable | 3k4vD-3vi3A:10.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdj | TYPE I PULLULANASE (Anoxybacillussp. LM18-11) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 3 | ARG A 321VAL A 344THR A 301 | None | 0.77A | 3k4vD-3wdjA:undetectable | 3k4vD-3wdjA:9.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cti | OSMOLARITY SENSORPROTEIN ENVZ, AF1503 (Archaeoglobusfulgidus;Escherichiacoli) |
PF00512(HisKA)PF00672(HAMP)PF02518(HATPase_c) | 3 | ARG A 282VAL A 303THR A 290 | None | 0.70A | 3k4vD-4ctiA:undetectable | 3k4vD-4ctiA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d1t | METALLO-B-LACTAMASE (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 3 | ARG A 121VAL A 127THR A 92 | ZN A1293 ( 4.7A)NoneNone | 0.80A | 3k4vD-4d1tA:undetectable | 3k4vD-4d1tA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcy | TRANSPOSASE (Escherichiavirus Mu) |
PF02316(HTH_Tnp_Mu_1)PF02914(DDE_2)PF09039(HTH_Tnp_Mu_2)PF09299(Mu-transpos_C) | 3 | ARG A 324VAL A 467THR A 297 | None | 0.81A | 3k4vD-4fcyA:undetectable | 3k4vD-4fcyA:10.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fff | LEVANFRUCTOTRANSFERASE (Paenarthrobacterureafaciens) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | ARG A 461VAL A 382THR A 502 | None | 0.59A | 3k4vD-4fffA:undetectable | 3k4vD-4fffA:12.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g59 | M152 PROTEIN (Muridbetaherpesvirus1) |
PF11624(M157) | 3 | ARG C 180VAL C 174THR C 254 | None | 0.80A | 3k4vD-4g59C:undetectable | 3k4vD-4g59C:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h2h | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Salipigerbermudensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ARG A 314VAL A 131THR A 128 | None | 0.70A | 3k4vD-4h2hA:undetectable | 3k4vD-4h2hA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyj | RHODOPSIN (Exiguobacteriumsibiricum) |
PF01036(Bac_rhodopsin) | 3 | ARG A 33VAL A 226THR A 51 | None | 0.59A | 3k4vD-4hyjA:undetectable | 3k4vD-4hyjA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jde | PROTEIN F15E11.1 (Caenorhabditiselegans) |
no annotation | 3 | ARG B 119VAL B 9THR B 67 | NoneNone CL B 201 (-4.4A) | 0.69A | 3k4vD-4jdeB:undetectable | 3k4vD-4jdeB:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jkl | BETA-GLUCURONIDASE (Streptococcusagalactiae) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 3 | ARG A 54VAL A 39THR A 42 | None | 0.70A | 3k4vD-4jklA:undetectable | 3k4vD-4jklA:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k91 | D-ALA-D-ALA-CARBOXYPEPTIDASE (Pseudomonasaeruginosa) |
PF00768(Peptidase_S11)PF07943(PBP5_C) | 3 | ARG A 189VAL A 107THR A 75 | SIN A 601 ( 4.7A)NoneNone | 0.72A | 3k4vD-4k91A:undetectable | 3k4vD-4k91A:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ke4 | HYDROXYCINNAMOYL-COA:SHIKIMATEHYDROXYCINNAMOYLTRANSFERASE (Sorghum bicolor) |
PF02458(Transferase) | 3 | ARG A 304VAL A 210THR A 322 | PG4 A 502 (-2.8A)NoneNone | 0.61A | 3k4vD-4ke4A:undetectable | 3k4vD-4ke4A:11.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ktd | GE136 LIGHT CHAINFAB (Macaca mulatta) |
PF07654(C1-set)PF07686(V-set) | 3 | ARG L 103VAL L 146THR L 161 | None | 0.82A | 3k4vD-4ktdL:undetectable | 3k4vD-4ktdL:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ld6 | PWWPDOMAIN-CONTAININGPROTEIN 2B (Homo sapiens) |
PF00855(PWWP) | 3 | ARG A 554VAL A 488THR A 482 | None | 0.74A | 3k4vD-4ld6A:undetectable | 3k4vD-4ld6A:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lk2 | PRE-MRNA-PROCESSINGATP-DEPENDENT RNAHELICASE PRP5 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | ARG A 503VAL A 479THR A 616 | None | 0.79A | 3k4vD-4lk2A:undetectable | 3k4vD-4lk2A:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m9d | ADENYLOSUCCINATESYNTHETASE (Bacillusanthracis) |
PF00709(Adenylsucc_synt) | 3 | ARG A 146VAL A 67THR A 203 | None | 0.81A | 3k4vD-4m9dA:undetectable | 3k4vD-4m9dA:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mx3 | CAMP-DEPENDENTPROTEIN KINASE TYPEI-ALPHA REGULATORYSUBUNIT (Bos taurus) |
PF00027(cNMP_binding) | 3 | ARG A 262VAL A 192THR A 190 | None | 0.81A | 3k4vD-4mx3A:undetectable | 3k4vD-4mx3A:11.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0l | PREDICTED COMPONENTOF ATHERMOPHILE-SPECIFICDNA REPAIR SYSTEM,CONTAINS A RAMPDOMAIN (Methanopyruskandleri) |
PF03787(RAMPs) | 3 | ARG A 15VAL A 38THR A 20 | None | 0.84A | 3k4vD-4n0lA:undetectable | 3k4vD-4n0lA:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0r | PUTATIVE GLYCOSIDEHYDROLASE (Bacteroidesvulgatus) |
PF13204(DUF4038)PF16586(DUF5060) | 3 | ARG A 165VAL A 117THR A 323 | None | 0.78A | 3k4vD-4n0rA:undetectable | 3k4vD-4n0rA:12.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ARG A 8VAL A 32THR A 80 | RIT A 500 (-3.2A)NoneNone | 0.32A | 3k4vD-4njvA:20.3 | 3k4vD-4njvA:84.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oa7 | TANKYRASE-1 (Homo sapiens) |
PF00644(PARP) | 3 | ARG A1159VAL A1169THR A1255 | None | 0.83A | 3k4vD-4oa7A:undetectable | 3k4vD-4oa7A:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdr | NEUROPILIN-2 (Homo sapiens) |
PF00754(F5_F8_type_C) | 3 | ARG A 518VAL A 468THR A 367 | None | 0.78A | 3k4vD-4qdrA:undetectable | 3k4vD-4qdrA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tx7 | CLASS I CHITINASE (Vignaunguiculata) |
PF00182(Glyco_hydro_19) | 3 | ARG A 100VAL A 256THR A 239 | None | 0.74A | 3k4vD-4tx7A:undetectable | 3k4vD-4tx7A:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ui0 | RGM DOMAIN FAMILYMEMBER B (Homo sapiens) |
PF06535(RGM_N) | 3 | ARG C 86VAL C 109THR C 92 | None | 0.69A | 3k4vD-4ui0C:undetectable | 3k4vD-4ui0C:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v0h | METALLO-BETA-LACTAMASE DOMAIN-CONTAININGPROTEIN 1 1 (Homo sapiens) |
PF00753(Lactamase_B) | 3 | ARG A 239VAL A 182THR A 185 | None | 0.74A | 3k4vD-4v0hA:undetectable | 3k4vD-4v0hA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynv | ACL4 (Chaetomiumthermophilum) |
PF13432(TPR_16) | 3 | ARG A 169VAL A 179THR A 216 | None | 0.58A | 3k4vD-4ynvA:undetectable | 3k4vD-4ynvA:12.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5amq | RNA POLYMERASE L (Californiaencephalitisorthobunyavirus) |
PF04196(Bunya_RdRp)PF15518(L_protein_N) | 3 | ARG A1493VAL A1472THR A1689 | None | 0.75A | 3k4vD-5amqA:undetectable | 3k4vD-5amqA:3.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyr | RNA-DEPENDENT RNAPOLYMERASE (Thosea asignavirus) |
no annotation | 3 | ARG B 564VAL B 595THR B 590 | None | 0.67A | 3k4vD-5cyrB:undetectable | 3k4vD-5cyrB:8.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dbo | TRANSLATIONINITIATION FACTOREIF-2B-LIKE PROTEIN (Chaetomiumthermophilum) |
PF01008(IF-2B) | 3 | ARG A 330VAL A 295THR A 288 | None | 0.77A | 3k4vD-5dboA:undetectable | 3k4vD-5dboA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9a | BETA-GALACTOSIDASE (Rahnella sp. R3) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 3 | ARG A 683VAL A 652THR A 621 | None | 0.73A | 3k4vD-5e9aA:undetectable | 3k4vD-5e9aA:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exk | LIPOYL SYNTHASE (Mycobacteriumtuberculosis) |
PF04055(Radical_SAM)PF16881(LIAS_N) | 3 | ARG A 83VAL A 54THR A 121 | NoneNoneMET A 404 (-3.7A) | 0.76A | 3k4vD-5exkA:undetectable | 3k4vD-5exkA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw7 | GLUCOSIDASE YGJK (Escherichiacoli) |
PF01204(Trehalase) | 3 | ARG A 295VAL A 347THR A 325 | None | 0.80A | 3k4vD-5gw7A:undetectable | 3k4vD-5gw7A:9.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hoe | HYDROLASE (Sinorhizobiummeliloti) |
PF13472(Lipase_GDSL_2) | 3 | ARG A 35VAL A 21THR A 27 | None | 0.76A | 3k4vD-5hoeA:undetectable | 3k4vD-5hoeA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxw | L-AMINO ACIDDEAMINASE (Proteusvulgaris) |
PF01266(DAO) | 3 | ARG A 220VAL A 252THR A 249 | None | 0.79A | 3k4vD-5hxwA:undetectable | 3k4vD-5hxwA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i39 | L-AMINO ACIDDEAMINASE (Proteusvulgaris) |
PF01266(DAO) | 3 | ARG A 220VAL A 252THR A 249 | None | 0.64A | 3k4vD-5i39A:undetectable | 3k4vD-5i39A:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jry | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Burkholderiamultivorans) |
PF00171(Aldedh) | 3 | ARG A 79VAL A 68THR A 196 | None | 0.78A | 3k4vD-5jryA:undetectable | 3k4vD-5jryA:12.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj3 | PRP46 (Saccharomycescerevisiae) |
PF00400(WD40) | 3 | ARG J 312VAL J 272THR J 229 | None | 0.59A | 3k4vD-5lj3J:undetectable | 3k4vD-5lj3J:13.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mm4 | KINESIN-5 (Ustilago maydis) |
no annotation | 3 | ARG K 355VAL K 351THR K 361 | None | 0.81A | 3k4vD-5mm4K:undetectable | 3k4vD-5mm4K:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n94 | CG9323, ISOFORM A (Drosophilamelanogaster) |
no annotation | 3 | ARG A 555VAL A 529THR A 534 | None | 0.80A | 3k4vD-5n94A:undetectable | 3k4vD-5n94A:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd1 | CAPSID PROTEIN (Rosellinianecatrixquadrivirus 1) |
no annotation | 3 | ARG A 445VAL A 495THR A 129 | None | 0.82A | 3k4vD-5nd1A:undetectable | 3k4vD-5nd1A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o67 | FAPF (Pseudomonas sp.UK4) |
no annotation | 3 | ARG B 199VAL B 206THR B 234 | None | 0.80A | 3k4vD-5o67B:undetectable | 3k4vD-5o67B:16.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ARG A 8VAL A 32THR A 80 | None | 0.25A | 3k4vD-5t2zA:19.7 | 3k4vD-5t2zA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tpt | AMYLOID-LIKE PROTEIN2 (Homo sapiens) |
no annotation | 3 | ARG A 540VAL A 529THR A 507 | None | 0.83A | 3k4vD-5tptA:undetectable | 3k4vD-5tptA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuw | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH) | 3 | ARG A 440VAL A 360THR A 34 | None | 0.71A | 3k4vD-5uuwA:undetectable | 3k4vD-5uuwA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x32 | N-ACYLGLUCOSAMINE2-EPIMERASE (Marinomonasmediterranea) |
no annotation | 3 | ARG A 198VAL A 118THR A 140 | None | 0.71A | 3k4vD-5x32A:undetectable | 3k4vD-5x32A:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvs | PUTATIVE COREPROTEIN NTPASE/VP5VP2 (Aquareovirus C) |
no annotation | 3 | ARG 2 418VAL 4 536THR 4 407 | None | 0.79A | 3k4vD-5zvs2:undetectable | 3k4vD-5zvs2:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvt | C-TERMINUS OF OUTERCAPSID PROTEIN VP5 (Aquareovirus C) |
no annotation | 3 | ARG B 567VAL B 527THR B 536 | None | 0.82A | 3k4vD-5zvtB:undetectable | 3k4vD-5zvtB:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c62 | BIURET HYDROLASE (Pseudomonas sp.ADP) |
no annotation | 3 | ARG A 145VAL A 177THR A 372 | None | 0.74A | 3k4vD-6c62A:undetectable | 3k4vD-6c62A:27.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccv | - (-) |
no annotation | 3 | ARG F 442VAL F 413THR F 448 | None | 0.81A | 3k4vD-6ccvF:undetectable | 3k4vD-6ccvF:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eti | ATP-BINDING CASSETTESUB-FAMILY G MEMBER2 (Homo sapiens) |
no annotation | 3 | ARG A 147VAL A 136THR A 194 | None | 0.69A | 3k4vD-6etiA:undetectable | 3k4vD-6etiA:20.59 |