SIMILAR PATTERNS OF AMINO ACIDS FOR 3K37_B_BCZB468_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		3 ARG A 190
GLU A 209
TYR A 230
 None
 0.89A 3k37B-1chkA:
0.0		 3k37B-1chkA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.) 		PF05426
(Alginate_lyase) 		3 ARG A 282
GLU A 259
TYR A 220
 None
 0.89A 3k37B-1hv6A:
undetectable		 3k37B-1hv6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipi HOLLIDAY JUNCTION
RESOLVASE

(Pyrococcus
furiosus) 		PF01870
(Hjc) 		3 ARG A  60
GLU A  97
TYR A  56
 None
 0.95A 3k37B-1ipiA:
0.0		 3k37B-1ipiA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		3 ARG A 366
GLU A  57
TYR A 157
 TRS  A 601 (-3.5A)
None
None
 0.92A 3k37B-1lxyA:
0.0		 3k37B-1lxyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nff PUTATIVE
OXIDOREDUCTASE
RV2002

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		3 ARG A  17
GLU A  42
TYR A  57
 NAD  A1300 (-3.7A)
None
None
 0.93A 3k37B-1nffA:
0.0		 3k37B-1nffA:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG N 152
GLU N 276
TYR N 406
 None
 0.73A 3k37B-1nmbN:
53.4		 3k37B-1nmbN:
30.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa4 ENDO-BETA-1,4-GLUCAN
ASE

(Streptomyces
sp. 11AG8) 		PF01670
(Glyco_hydro_12) 		3 ARG A 118
GLU A 120
TYR A  66
 None
 0.83A 3k37B-1oa4A:
0.0		 3k37B-1oa4A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))
PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase) 		3 ARG B 134
GLU A 264
TYR A 396
 None
 0.95A 3k37B-1qdlB:
0.0		 3k37B-1qdlB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (GH-LOOP
FROM VIRUS CAPSID
PROTEIN VP1)
PROTEIN
(IMMUNOGLOBULIN
HEAVY CHAIN)

(Foot-and-mouth
disease virus;
Mus musculus) 		no annotation
PF07654
(C1-set)
PF07686
(V-set) 		3 ARG A  98
GLU A 105
TYR 5 136
 None
 0.84A 3k37B-1qgcA:
undetectable		 3k37B-1qgcA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r77 CELL WALL TARGETING
DOMAIN OF
GLYCYLGLYCINE
ENDOPEPTIDASE ALE-1

(Staphylococcus
capitis) 		PF08460
(SH3_5) 		3 ARG A 345
GLU A 283
TYR A 271
 None
 0.87A 3k37B-1r77A:
undetectable		 3k37B-1r77A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		3 ARG A 271
GLU A 279
TYR A  26
 None
 0.94A 3k37B-1szqA:
undetectable		 3k37B-1szqA:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 158
GLU A 283
TYR A 412
 None
 0.82A 3k37B-1v0zA:
53.8		 3k37B-1v0zA:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		3 ARG A 297
GLU A 289
TYR A 281
 None
 0.81A 3k37B-1wf3A:
undetectable		 3k37B-1wf3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		3 ARG A 292
GLU A 601
TYR A 325
 None
 0.88A 3k37B-1xfuA:
undetectable		 3k37B-1xfuA:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 153
GLU A 278
TYR A 406
 ABW  A1000 (-4.1A)
ABW  A1000 (-4.1A)
ABW  A1000 (-4.9A)
 0.84A 3k37B-1xogA:
53.3		 3k37B-1xogA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs8 HISTOCOMPATIBILITY
2, M REGION LOCUS
10.5

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ARG A   8
GLU A  62
TYR A  32
 None
 0.90A 3k37B-1zs8A:
undetectable		 3k37B-1zs8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 ARG B 486
GLU B 489
TYR A 186
 None
 0.93A 3k37B-2amcB:
undetectable		 3k37B-2amcB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqx INORGANIC
PYROPHOSPHATASE

(Helicobacter
pylori) 		PF00719
(Pyrophosphatase) 		3 ARG A  42
GLU A  30
TYR A  54
 None
 0.83A 3k37B-2bqxA:
undetectable		 3k37B-2bqxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 358
GLU A 206
TYR A 670
 008  A1767 ( 4.0A)
008  A1767 (-2.5A)
None
 0.92A 3k37B-2bucA:
2.2		 3k37B-2bucA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 ARG A 169
GLU A 164
TYR A 281
 None
 0.88A 3k37B-2c4kA:
undetectable		 3k37B-2c4kA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		3 ARG A  64
GLU A 133
TYR A 119
 None
 0.84A 3k37B-2c4tA:
undetectable		 3k37B-2c4tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj0 THIOREDOXIN-RELATED
TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 ARG A 124
GLU A 130
TYR A  55
 None
 0.94A 3k37B-2dj0A:
undetectable		 3k37B-2dj0A:
15.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
GLU A 276
TYR A 406
 None
 0.25A 3k37B-2htvA:
51.8		 3k37B-2htvA:
36.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j66 BTRK

(Bacillus
circulans) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 ARG A 134
GLU A  86
TYR A  45
 None
 0.90A 3k37B-2j66A:
undetectable		 3k37B-2j66A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE

(Archaeoglobus
fulgidus) 		PF00730
(HhH-GPD) 		3 ARG A  56
GLU A  86
TYR A 106
 None
 0.83A 3k37B-2jhnA:
undetectable		 3k37B-2jhnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kny LRP-1, LINKER, APO-E

(Homo sapiens) 		PF00057
(Ldl_recept_a) 		3 ARG A  24
GLU A  39
TYR A  47
 None
CA  A  81 (-2.8A)
None
 0.89A 3k37B-2knyA:
undetectable		 3k37B-2knyA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kp5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Hahella
chejuensis) 		PF00030
(Crystall) 		3 ARG A  75
GLU A  72
TYR A  66
 None
 0.92A 3k37B-2kp5A:
undetectable		 3k37B-2kp5A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 ARG B 732
GLU B 707
TYR B 589
 None
 0.85A 3k37B-2o8eB:
undetectable		 3k37B-2o8eB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 ARG A 186
GLU A 585
TYR A 489
 None
 0.88A 3k37B-2okjA:
undetectable		 3k37B-2okjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 ARG A 177
GLU A 576
TYR A 480
 None
 0.93A 3k37B-2okkA:
undetectable		 3k37B-2okkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oys HYPOTHETICAL PROTEIN
SP1951

(Streptococcus
pneumoniae) 		PF03358
(FMN_red) 		3 ARG A 217
GLU A 226
TYR A 193
 None
 0.58A 3k37B-2oysA:
undetectable		 3k37B-2oysA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		3 ARG A  73
GLU A  67
TYR A  96
 GRG  A 500 (-2.9A)
None
None
 0.88A 3k37B-2q80A:
undetectable		 3k37B-2q80A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf9 PUTATIVE SECRETED
PROTEIN

(Streptomyces
coelicolor) 		PF03713
(DUF305) 		3 ARG A  75
GLU A 191
TYR A 150
 None
 0.80A 3k37B-2qf9A:
undetectable		 3k37B-2qf9A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 ARG A  48
GLU A  53
TYR A 226
 None
 0.87A 3k37B-2rfqA:
undetectable		 3k37B-2rfqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 ARG A 114
GLU B 508
TYR B 579
 None
 0.92A 3k37B-2rhqA:
undetectable		 3k37B-2rhqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 ARG A 352
GLU A 461
TYR A 501
 None
 0.89A 3k37B-2uuuA:
undetectable		 3k37B-2uuuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A  21
GLU A  94
TYR A  87
 None
 0.75A 3k37B-2wu5A:
undetectable		 3k37B-2wu5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		3 ARG A 388
GLU A 423
TYR A 412
 None
 0.82A 3k37B-2xa7A:
undetectable		 3k37B-2xa7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		PF00467
(KOW)
PF02357
(NusG) 		3 ARG A 209
GLU A 348
TYR A 286
 None
 0.80A 3k37B-2xhcA:
undetectable		 3k37B-2xhcA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		3 ARG F 113
GLU F  85
TYR F 164
 None
 0.82A 3k37B-2xwbF:
undetectable		 3k37B-2xwbF:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjl EXOENZYME S
SYNTHESIS PROTEIN B

(Pseudomonas
aeruginosa) 		PF09619
(YscW) 		3 ARG A  64
GLU A  93
TYR A  50
 None
 0.91A 3k37B-2yjlA:
undetectable		 3k37B-2yjlA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b74 UNCHARACTERIZED
PROTEIN YKL091C

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		3 ARG A 102
GLU A 126
TYR A 195
 None
PEE  A 311 ( 4.1A)
PEE  A 311 (-4.0A)
 0.95A 3k37B-3b74A:
undetectable		 3k37B-3b74A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A  90
GLU A 286
TYR A 289
 None
MG  A 501 (-2.5A)
None
 0.84A 3k37B-3bjsA:
undetectable		 3k37B-3bjsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE

(Escherichia
coli) 		PF03864
(Phage_cap_E) 		3 ARG A 127
GLU A  24
TYR A  16
 None
 0.88A 3k37B-3bqwA:
undetectable		 3k37B-3bqwA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
GLU A 276
TYR A 406
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-4.7A)
 0.47A 3k37B-3ckzA:
53.6		 3k37B-3ckzA:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 341
GLU A 343
TYR A 351
 None
 0.76A 3k37B-3iv0A:
undetectable		 3k37B-3iv0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kal HOMOGLUTATHIONE
SYNTHETASE

(Glycine max) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		3 ARG A 153
GLU A 246
TYR A 293
 HGS  A 501 ( 2.8A)
None
None
 0.91A 3k37B-3kalA:
undetectable		 3k37B-3kalA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2p DNA LIGASE 3

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 ARG A 527
GLU A 536
TYR A 422
 None
None
AMP  A 901 (-4.6A)
 0.88A 3k37B-3l2pA:
undetectable		 3k37B-3l2pA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 3 ARG A  86
GLU A 224
TYR A 163
 None
 0.94A 3k37B-3ll7A:
undetectable		 3k37B-3ll7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		3 ARG A 315
GLU A 158
TYR A 278
 LEU  A 400 (-2.7A)
None
None
 0.80A 3k37B-3lopA:
undetectable		 3k37B-3lopA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE

(Burkholderia
pseudomallei) 		PF00850
(Hist_deacetyl) 		3 ARG A 159
GLU A 231
TYR A 211
 None
 0.92A 3k37B-3menA:
undetectable		 3k37B-3menA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		3 ARG A 205
GLU A 131
TYR A 162
 PLP  A1001 ( 4.6A)
PLP  A1001 ( 4.4A)
None
 0.85A 3k37B-3n2oA:
undetectable		 3k37B-3n2oA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		3 ARG A 446
GLU A 319
TYR A  71
 None
 0.89A 3k37B-3nztA:
undetectable		 3k37B-3nztA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ARG A 170
GLU A 163
TYR A   7
 XPE  A 277 (-3.1A)
XPE  A 277 ( 4.7A)
None
 0.90A 3k37B-3rwgA:
undetectable		 3k37B-3rwgA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 ARG A 257
GLU A 289
TYR A 455
 None
 0.95A 3k37B-3sm9A:
undetectable		 3k37B-3sm9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		3 ARG A  83
GLU A   5
TYR A 154
 None
 0.85A 3k37B-3t5tA:
undetectable		 3k37B-3t5tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 ARG A 439
GLU A 302
TYR A 343
 None
 0.88A 3k37B-3tchA:
undetectable		 3k37B-3tchA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
GLU A 276
TYR A 406
 LNV  A 901 (-4.0A)
LNV  A 901 (-2.9A)
LNV  A 901 (-4.8A)
 0.23A 3k37B-3ti8A:
53.9		 3k37B-3ti8A:
35.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
GLU A 276
TYR A 406
 LNV  A 801 (-3.9A)
LNV  A 801 (-2.9A)
LNV  A 801 (-4.4A)
 0.26A 3k37B-3tiaA:
54.9		 3k37B-3tiaA:
29.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		3 ARG A 468
GLU A 125
TYR A  97
 None
 0.87A 3k37B-3tr5A:
undetectable		 3k37B-3tr5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 ARG A 108
GLU A 137
TYR A 112
 None
 0.82A 3k37B-3ummA:
undetectable		 3k37B-3ummA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzi ACETYLGLUTAMATE
KINASE

(Saccharomyces
cerevisiae) 		PF00696
(AA_kinase)
PF04768
(NAT) 		3 ARG A 191
GLU A 184
TYR A 124
 None
 0.87A 3k37B-3zziA:
undetectable		 3k37B-3zziA:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
GLU A 277
TYR A 402
 G39  A1470 (-3.9A)
G39  A1470 (-3.7A)
G39  A1470 (-4.5A)
 0.77A 3k37B-4b7jA:
53.1		 3k37B-4b7jA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 ARG A 149
GLU A 274
TYR A 408
 ZMR  A 700 (-4.0A)
ZMR  A 700 (-2.7A)
ZMR  A 700 (-4.6A)
 0.48A 3k37B-4cpnA:
74.9		 3k37B-4cpnA:
97.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		3 ARG A 350
GLU A 171
TYR A 325
 None
 0.65A 3k37B-4dwqA:
undetectable		 3k37B-4dwqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 ARG B 558
GLU B 550
TYR B 540
 None
 0.86A 3k37B-4f92B:
undetectable		 3k37B-4f92B:
12.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
GLU A 276
TYR A 406
 G39  A 509 (-3.9A)
G39  A 509 ( 4.1A)
G39  A 509 (-4.6A)
 0.91A 3k37B-4hzzA:
52.3		 3k37B-4hzzA:
34.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 ARG A 831
GLU A 554
TYR A1077
 None
 0.93A 3k37B-4j3bA:
undetectable		 3k37B-4j3bA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 ARG A 449
GLU A 487
TYR A 465
 None
 0.75A 3k37B-4jklA:
undetectable		 3k37B-4jklA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kn5 METHYLTHIOADENOSINE
NUCLEOSIDASE

(Weissella
paramesenteroides) 		PF01048
(PNP_UDP_1) 		3 ARG A 194
GLU A  12
TYR A 133
 None
 0.84A 3k37B-4kn5A:
undetectable		 3k37B-4kn5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		3 ARG A 297
GLU A 223
TYR A 232
 None
 0.94A 3k37B-4kvlA:
undetectable		 3k37B-4kvlA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
GLU A 276
TYR A 406
 27S  A 501 (-4.2A)
27S  A 501 ( 3.7A)
27S  A 501 (-4.6A)
 0.79A 3k37B-4mjuA:
52.1		 3k37B-4mjuA:
35.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxt UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF16584
(LolA_2) 		3 ARG A 126
GLU A 155
TYR A 158
 None
 0.91A 3k37B-4mxtA:
undetectable		 3k37B-4mxtA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I) 		3 ARG E 170
GLU E 163
TYR E   7
 None
 0.83A 3k37B-4nhuE:
undetectable		 3k37B-4nhuE:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		3 ARG A  67
GLU A  69
TYR A  58
 None
 0.95A 3k37B-4o8uA:
undetectable		 3k37B-4o8uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		3 ARG A 348
GLU A 322
TYR A 156
 None
 0.59A 3k37B-4ojzA:
undetectable		 3k37B-4ojzA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz3 CD44 ANTIGEN

(Homo sapiens) 		PF00193
(Xlink) 		3 ARG A 150
GLU A  37
TYR A 117
 None
PEG  A 201 (-2.6A)
None
 0.81A 3k37B-4pz3A:
undetectable		 3k37B-4pz3A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhk UCA HEAVY CHAIN

(Homo sapiens) 		no annotation 3 ARG M  66
GLU M  46
TYR M  90
 None
 0.89A 3k37B-4qhkM:
undetectable		 3k37B-4qhkM:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A  70
GLU A 195
TYR A 324
 None
 0.88A 3k37B-4qn3A:
53.5		 3k37B-4qn3A:
32.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		3 ARG A 428
GLU A 435
TYR A 452
 SO4  A 901 (-3.7A)
None
None
 0.87A 3k37B-4xhcA:
undetectable		 3k37B-4xhcA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		3 ARG A 375
GLU A 234
TYR A 309
 None
 0.79A 3k37B-4xuvA:
undetectable		 3k37B-4xuvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		3 ARG A 205
GLU A 219
TYR A 261
 None
 0.79A 3k37B-5ap9A:
undetectable		 3k37B-5ap9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		3 ARG A 200
GLU A 215
TYR A 550
 None
 0.90A 3k37B-5bptA:
10.2		 3k37B-5bptA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5caa NUCLEOSIDE
DIPHOSPHATE KINASE

(Leishmania
major) 		PF00334
(NDK) 		3 ARG A  87
GLU A   4
TYR A  32
 None
 0.87A 3k37B-5caaA:
undetectable		 3k37B-5caaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flj QUERCETINASE QUED

(Streptomyces
sp. FLA) 		PF07883
(Cupin_2) 		3 ARG A  10
GLU A  47
TYR A  23
 None
 0.91A 3k37B-5fljA:
undetectable		 3k37B-5fljA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		3 ARG A 301
GLU A 345
TYR A 367
 None
 0.94A 3k37B-5j7tA:
undetectable		 3k37B-5j7tA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 ARG A  66
GLU A  97
TYR A  70
 None
 0.89A 3k37B-5jd4A:
undetectable		 3k37B-5jd4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN

(Thermococcus
kodakarensis) 		PF08443
(RimK) 		3 ARG A 253
GLU A  13
TYR A 175
 None
 0.89A 3k37B-5k2mA:
undetectable		 3k37B-5k2mA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcy FRMR

(Salmonella
enterica) 		PF02583
(Trns_repr_metal) 		3 ARG A  14
GLU A  58
TYR A  89
 None
 0.81A 3k37B-5lcyA:
undetectable		 3k37B-5lcyA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		3 ARG B 547
GLU B 490
TYR B 540
 None
 0.87A 3k37B-5lxzB:
7.2		 3k37B-5lxzB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		3 ARG A 695
GLU A 700
TYR A 757
 None
 0.84A 3k37B-5mqmA:
undetectable		 3k37B-5mqmA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7k AOAA13

(Aspergillus
oryzae) 		PF03067
(LPMO_10) 		3 ARG A  12
GLU A  80
TYR A  73
 None
 0.71A 3k37B-5t7kA:
undetectable		 3k37B-5t7kA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		3 ARG A  79
GLU A 111
TYR A 132
 None
 0.85A 3k37B-5tprA:
undetectable		 3k37B-5tprA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 ARG A 131
GLU A 395
TYR A 164
 None
 0.75A 3k37B-5u7qA:
undetectable		 3k37B-5u7qA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN

(Vibrio
vulnificus) 		no annotation 3 ARG A3933
GLU A3821
TYR A3833
 ARG  A3933 ( 0.6A)
GLU  A3821 ( 0.6A)
TYR  A3833 ( 1.3A)
 0.94A 3k37B-5w6lA:
undetectable		 3k37B-5w6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 ARG A1023
GLU A 950
TYR A 988
 None
 0.79A 3k37B-5xgjA:
undetectable		 3k37B-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9c MAJOR CAPSID PROTEIN
L1
HEAVY CHAIN OF FAB
FRAGMENT OF ANTIBODY
A12A3

(Alphapapillomavirus
9;
Mus musculus) 		no annotation
no annotation 		3 ARG A 135
GLU H  54
TYR H  33
 None
 0.95A 3k37B-5y9cA:
undetectable		 3k37B-5y9cA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 3 ARG A 244
GLU A 528
TYR A 534
 None
 0.85A 3k37B-5yv5A:
undetectable		 3k37B-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 3 ARG A 152
GLU A 276
TYR A 406
 E3M  A 511 (-3.8A)
E3M  A 511 (-2.3A)
E3M  A 511 (-4.5A)
 0.26A 3k37B-6br6A:
54.4		 3k37B-6br6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf -

(-) 		no annotation 3 ARG 5  66
GLU 5  46
TYR 5  90
 None
 0.92A 3k37B-6cuf5:
undetectable		 3k37B-6cuf5:
undetectable