SIMILAR PATTERNS OF AMINO ACIDS FOR 3K2H_A_LYAA514_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a21 | TISSUE FACTOR (Oryctolaguscuniculus) |
PF01108(Tissue_fac)PF09294(Interfer-bind) | 5 | ALA A 143PHE A 17LEU A 141LEU A 106LEU A 149 | None | 1.15A | 3k2hA-1a21A:undetectable | 3k2hA-1a21A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cz3 | DIHYDROFOLATEREDUCTASE (Thermotogamaritima) |
PF00186(DHFR_1) | 7 | ALA A 8ASP A 27ARG A 32THR A 47ILE A 51LEU A 55ARG A 58 | NoneNoneNoneSO4 A 200 (-3.7A)NoneNoneNone | 0.88A | 3k2hA-1cz3A:18.1 | 3k2hA-1cz3A:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dr6 | DIHYDROFOLATEREDUCTASE (Gallus gallus) |
PF00186(DHFR_1) | 6 | ALA A 9THR A 56ILE A 60LEU A 67ARG A 70TYR A 121 | HBI A 198 ( 3.6A)NAP A 191 (-3.5A)NoneNoneNoneNone | 0.70A | 3k2hA-1dr6A:24.5 | 3k2hA-1dr6A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gji | C-REL PROTO-ONCOGENEPROTEIN (Gallus gallus) |
PF00554(RHD_DNA_bind)PF16179(RHD_dimer) | 5 | ALA A 31LEU A 78ILE A 174LEU A 149LEU A 104 | None | 1.05A | 3k2hA-1gjiA:undetectable | 3k2hA-1gjiA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4v | HISTIDYL-TRNASYNTHETASE (Thermusthermophilus) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 5 | PHE B 307LEU B 282ARG B 311ILE B 23LEU B 156 | None | 1.09A | 3k2hA-1h4vB:undetectable | 3k2hA-1h4vB:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i5g | TRYPAREDOXIN II (Crithidiafasciculata) |
PF13905(Thioredoxin_8) | 5 | ALA A 19ASP A 21LEU A 27LEU A 88TYR A 82 | None | 1.04A | 3k2hA-1i5gA:undetectable | 3k2hA-1i5gA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldk | CULLIN HOMOLOG (Homo sapiens) |
PF00888(Cullin)PF10557(Cullin_Nedd8) | 5 | ALA B 656THR B 667ILE B 669LEU B 640LEU B 663 | None | 1.02A | 3k2hA-1ldkB:undetectable | 3k2hA-1ldkB:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o7f | CAMP-DEPENDENT RAP1GUANINE-NUCLEOTIDEEXCHANGE FACTOR (Mus musculus) |
PF00027(cNMP_binding)PF00610(DEP) | 5 | ALA A 85LEU A 135ARG A 137ILE A 68LEU A 88 | None | 1.15A | 3k2hA-1o7fA:undetectable | 3k2hA-1o7fA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ovm | INDOLE-3-PYRUVATEDECARBOXYLASE (Enterobactercloacae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 136LEU A 153ARG A 14ILE A 99LEU A 15 | None | 1.08A | 3k2hA-1ovmA:undetectable | 3k2hA-1ovmA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u70 | DIHYDROFOLATEREDUCTASE (Mus musculus) |
PF00186(DHFR_1) | 7 | ALA A 9PHE A 31THR A 56ILE A 60LEU A 67ARG A 70TYR A 121 | NDP A 188 (-3.6A)MTX A 187 (-4.3A)NDP A 188 (-3.9A)MTX A 187 ( 4.2A)MTX A 187 ( 4.5A)MTX A 187 (-3.1A)None | 0.68A | 3k2hA-1u70A:23.9 | 3k2hA-1u70A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u71 | DIHYDROFOLATEREDUCTASE (Homo sapiens) |
PF00186(DHFR_1) | 6 | ALA A 9THR A 56ILE A 60LEU A 67ARG A 70TYR A 121 | MXA A 187 (-3.6A)SO4 A 188 (-3.5A)MXA A 187 ( 4.7A)NoneNoneNone | 0.45A | 3k2hA-1u71A:24.3 | 3k2hA-1u71A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w25 | STALKED-CELLDIFFERENTIATIONCONTROLLING PROTEIN (Caulobactervibrioides) |
PF00072(Response_reg)PF00990(GGDEF) | 6 | ASP A 109LEU A 112ARG A 115ILE A 5LEU A 51LEU A 18 | None | 1.48A | 3k2hA-1w25A:undetectable | 3k2hA-1w25A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xa6 | BETA2-CHIMAERIN (Homo sapiens) |
PF00017(SH2)PF00130(C1_1)PF00620(RhoGAP) | 5 | LEU A 458THR A 366ILE A 362LEU A 401LEU A 390 | None | 1.11A | 3k2hA-1xa6A:undetectable | 3k2hA-1xa6A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 6 | ALA A 7ASP A 27THR A 46ILE A 50LEU A 54ARG A 57 | NoneNoneSO4 A3483 (-3.5A)SO4 A3486 ( 4.8A)SO4 A3486 (-4.2A)SO4 A3484 (-3.3A) | 0.85A | 3k2hA-1zdrA:21.2 | 3k2hA-1zdrA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2blb | DIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumvivax) |
PF00186(DHFR_1) | 6 | ALA A 15ASP A 53ILE A 121LEU A 128ARG A 131TYR A 179 | CP7 A1240 (-3.7A)CP7 A1240 (-3.1A)MES A1241 ( 4.1A)MES A1241 (-4.5A)MES A1241 (-2.7A)None | 0.57A | 3k2hA-2blbA:24.3 | 3k2hA-2blbA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dh3 | 4F2 CELL-SURFACEANTIGEN HEAVY CHAIN (Homo sapiens) |
PF00128(Alpha-amylase) | 5 | ALA A 137PHE A 132LEU A 129LEU A 160LEU A 140 | None | 0.91A | 3k2hA-2dh3A:undetectable | 3k2hA-2dh3A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmu | PUTATIVEPYRIDOXAMINE5-PHOSPHATE-DEPENDENT DEHYDRASE, WBDK (Escherichiacoli) |
PF01041(DegT_DnrJ_EryC1) | 5 | THR A 335ILE A 333SER A 305LEU A 136TYR A 92 | None | 0.94A | 3k2hA-2gmuA:undetectable | 3k2hA-2gmuA:22.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 8 | ALA A 28ASP A 48ARG A 53THR A 80ILE A 84LEU A 91ARG A 94TYR A 160 | NAP A 523 (-3.7A)NoneNoneNAP A 523 (-3.5A)NoneNoneNoneNone | 0.83A | 3k2hA-2h2qA:38.8 | 3k2hA-2h2qA:39.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inv | INSULINFRUCTOTRANSFERASE (Bacillus sp.snu-7) |
no annotation | 5 | ALA A 76ASP A 73LEU A 109ARG A 154ILE A 102 | None | 1.16A | 3k2hA-2invA:undetectable | 3k2hA-2invA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2izo | FLAPSTRUCTURE-SPECIFICENDONUCLEASE (Sulfolobussolfataricus) |
PF00752(XPG_N)PF00867(XPG_I) | 5 | LEU A 223THR A 232ILE A 230LEU A 3LEU A 175 | None | 1.16A | 3k2hA-2izoA:undetectable | 3k2hA-2izoA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1e | YCDH (Bacillussubtilis) |
PF01297(ZnuA) | 5 | ALA A 244LEU A 252ILE A 189LEU A 226LEU A 212 | None | 1.11A | 3k2hA-2o1eA:undetectable | 3k2hA-2o1eA:19.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 7 | ALA A 11ASP A 32THR A 58ILE A 62LEU A 67ARG A 70TYR A 119 | MTX A 605 ( 3.6A)MTX A 605 ( 3.0A)NDP A 606 ( 3.5A)MTX A 605 ( 4.6A)MTX A 605 ( 4.4A)MTX A 605 ( 3.1A)None | 0.57A | 3k2hA-2oipA:43.6 | 3k2hA-2oipA:46.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qk8 | DIHYDROFOLATEREDUCTASE (Bacillusanthracis) |
PF00186(DHFR_1) | 5 | ALA A 8ILE A 51LEU A 55ARG A 58TYR A 102 | MTX A 200 ( 3.4A)MTX A 200 ( 4.2A)MTX A 200 ( 4.1A)MTX A 200 ( 2.8A)None | 0.61A | 3k2hA-2qk8A:21.6 | 3k2hA-2qk8A:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9q | 2'-DEOXYCYTIDINE5'-TRIPHOSPHATEDEAMINASE (Agrobacteriumfabrum) |
PF06559(DCD) | 5 | PHE A 290LEU A 256ILE A 207LEU A 264LEU A 254 | None | 1.01A | 3k2hA-2r9qA:undetectable | 3k2hA-2r9qA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uwj | TYPE III EXPORTPROTEIN PSCETYPE III EXPORTPROTEIN PSCG (Pseudomonasaeruginosa) |
PF08988(T3SS_needle_E)PF09477(Type_III_YscG) | 5 | ASP G 2LEU G 5ARG G 7ILE G 28LEU E 27 | None | 1.12A | 3k2hA-2uwjG:undetectable | 3k2hA-2uwjG:13.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vbf | BRANCHED-CHAINALPHA-KETOACIDDECARBOXYLASE (Lactococcuslactis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 133LEU A 150ARG A 11ILE A 96LEU A 12 | ALA A 133 ( 0.0A)LEU A 150 ( 0.5A)ARG A 11 ( 0.6A)ILE A 96 ( 0.6A)LEU A 12 ( 0.6A) | 1.11A | 3k2hA-2vbfA:undetectable | 3k2hA-2vbfA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3w | DIHYDROFOLATEREDUCTASE (Mycobacteriumavium) |
PF00186(DHFR_1) | 6 | ALA A 11ASP A 31THR A 50LEU A 61ARG A 64TYR A 108 | VG9 A1168 ( 3.8A)VG9 A1168 (-3.0A)NDP A1169 (-3.4A)VG9 A1168 ( 4.4A)VG9 A1168 ( 3.7A)None | 0.67A | 3k2hA-2w3wA:21.9 | 3k2hA-2w3wA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9s | DIHYDROFOLATEREDUCTASE TYPE 1FROM TN4003 (Staphylococcusaureus) |
PF00186(DHFR_1) | 7 | ALA A 7ASP A 27THR A 46ILE A 50LEU A 54ARG A 57TYR A 98 | TOP A1160 ( 3.6A)TOP A1160 (-2.8A)NDP A1159 (-3.3A)TOP A1160 (-4.4A)NoneNoneNone | 0.69A | 3k2hA-2w9sA:21.6 | 3k2hA-2w9sA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xh1 | KYNURENINE/ALPHA-AMINOADIPATEAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF00155(Aminotran_1_2) | 5 | LEU A 417ILE A 363SER A 424LEU A 369LEU A 398 | None | 1.13A | 3k2hA-2xh1A:undetectable | 3k2hA-2xh1A:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjq | CEL44C (Paenibacilluspolymyxa) |
PF12891(Glyco_hydro_44) | 5 | ALA A 437PHE A 464LEU A 466ARG A 500ILE A 493 | None | 1.09A | 3k2hA-2yjqA:undetectable | 3k2hA-2yjqA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yz2 | PUTATIVE ABCTRANSPORTERATP-BINDING PROTEINTM_0222 (Thermotogamaritima) |
PF00005(ABC_tran) | 5 | ASP A 219LEU A 28THR A 190ILE A 192LEU A 50 | None | 1.14A | 3k2hA-2yz2A:undetectable | 3k2hA-2yz2A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfr | DIHYDROFOLATEREDUCTASE (Lactobacilluscasei) |
PF00186(DHFR_1) | 5 | ALA A 6ASP A 26THR A 45LEU A 54ARG A 57 | MTX A 164 (-3.8A)MTX A 164 ( 2.9A)NDP A 163 (-3.4A)MTX A 164 ( 4.4A)MTX A 164 ( 2.9A) | 0.62A | 3k2hA-3dfrA:22.4 | 3k2hA-3dfrA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 6 | ALA A 16ARG A 59ILE A 112LEU A 119LEU A 164TYR A 170 | RJ6 A 609 (-3.7A)NoneRJ6 A 609 (-4.8A)RJ6 A 609 (-4.4A)RJ6 A 609 ( 4.1A)NDP A 610 ( 4.9A) | 1.24A | 3k2hA-3dg8A:24.7 | 3k2hA-3dg8A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 7 | ALA A 16ASP A 54ILE A 112LEU A 119ARG A 122LEU A 164TYR A 170 | RJ6 A 609 (-3.7A)RJ6 A 609 (-3.0A)RJ6 A 609 (-4.8A)RJ6 A 609 (-4.4A)NoneRJ6 A 609 ( 4.1A)NDP A 610 ( 4.9A) | 0.69A | 3k2hA-3dg8A:24.7 | 3k2hA-3dg8A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emv | URIDINEPHOSPHORYLASE,PUTATIVE (Plasmodiumvivax) |
PF01048(PNP_UDP_1) | 6 | ALA A 112PHE A 204THR A 200ILE A 88SER A 234LEU A 139 | None | 1.10A | 3k2hA-3emvA:undetectable | 3k2hA-3emvA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f83 | FUSION OF THE MINORPILIN CFAE AND MAJORPILIN CFAB (Escherichiacoli) |
PF04449(Fimbrial_CS1)PF07434(CblD) | 5 | ALA A 427LEU A 505ILE A 483LEU A 481LEU A 453 | None | 1.15A | 3k2hA-3f83A:undetectable | 3k2hA-3f83A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f85 | HOMO TRIMERIC FUSIONOF CFA/I FIMBRIALSUBUNITS B (Escherichiacoli) |
PF04449(Fimbrial_CS1) | 5 | ALA A 50LEU A 128ILE A 106LEU A 104LEU A 76 | None | 1.10A | 3k2hA-3f85A:undetectable | 3k2hA-3f85A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f85 | HOMO TRIMERIC FUSIONOF CFA/I FIMBRIALSUBUNITS B (Escherichiacoli) |
PF04449(Fimbrial_CS1) | 5 | ALA A 201LEU A 279ILE A 257LEU A 255LEU A 227 | None | 1.13A | 3k2hA-3f85A:undetectable | 3k2hA-3f85A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fjo | NADPH-CYTOCHROMEP450 REDUCTASE (Homo sapiens;Saccharomycescerevisiae) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 6 | ALA A 51PHE A 101LEU A 104ILE A 113LEU A 171LEU A 145 | None | 1.44A | 3k2hA-3fjoA:3.0 | 3k2hA-3fjoA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8a | DIHYDROFOLATEREDUCTASE (Staphylococcusaureus) |
PF00186(DHFR_1) | 7 | ALA X 7ASP X 27THR X 46ILE X 50LEU X 54ARG X 57TYR X 98 | N22 X 219 ( 3.6A)N22 X 219 (-2.8A)NDP X 207 (-3.2A)N22 X 219 (-4.6A)NoneNoneNone | 0.82A | 3k2hA-3i8aX:21.5 | 3k2hA-3i8aX:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ia4 | DIHYDROFOLATEREDUCTASE (Moritellaprofunda) |
PF00186(DHFR_1) | 6 | ALA A 8THR A 47ILE A 51LEU A 55ARG A 58TYR A 102 | MTX A 164 ( 3.7A)NDP A 163 (-3.4A)MTX A 164 (-4.1A)MTX A 164 ( 4.4A)MTX A 164 (-2.9A)None | 0.73A | 3k2hA-3ia4A:21.8 | 3k2hA-3ia4A:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j7a | 40S RIBOSOMALPROTEIN US5 (Plasmodiumfalciparum) |
PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C) | 5 | ALA G 115ILE G 179SER G 210LEU G 181LEU G 230 | None | 1.01A | 3k2hA-3j7aG:undetectable | 3k2hA-3j7aG:19.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 8 | ALA A 16ASP A 37LEU A 41THR A 69LEU A 80ARG A 83LEU A 123TYR A 129 | NAP A 512 (-3.7A)NoneNoneNAP A 512 (-3.6A)NoneNoneNoneNone | 0.31A | 3k2hA-3kjrA:52.9 | 3k2hA-3kjrA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 8 | ALA A 16LEU A 41THR A 69ILE A 73LEU A 80ARG A 83LEU A 123TYR A 129 | NAP A 512 (-3.7A)NoneNAP A 512 (-3.6A)NoneNoneNoneNoneNone | 0.65A | 3k2hA-3kjrA:52.9 | 3k2hA-3kjrA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 8 | LEU A 41ARG A 42THR A 69ILE A 73LEU A 80ARG A 83LEU A 123TYR A 129 | NoneNoneNAP A 512 (-3.6A)NoneNoneNoneNoneNone | 0.88A | 3k2hA-3kjrA:52.9 | 3k2hA-3kjrA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | THR A 69ILE A 73SER A 77LEU A 80TYR A 129 | NAP A 512 (-3.6A)NoneNoneNoneNone | 0.84A | 3k2hA-3kjrA:52.9 | 3k2hA-3kjrA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzg | ARGININE 3RDTRANSPORT SYSTEMPERIPLASMIC BINDINGPROTEIN (Legionellapneumophila) |
PF00497(SBP_bac_3) | 5 | ALA A 213LEU A 220ILE A 53LEU A 57LEU A 21 | None | 0.99A | 3k2hA-3kzgA:undetectable | 3k2hA-3kzgA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mil | ISOAMYLACETATE-HYDROLYZINGESTERASE (Saccharomycescerevisiae) |
PF13472(Lipase_GDSL_2) | 5 | LEU A 203ILE A 46LEU A 8LEU A 32TYR A 30 | None | 1.00A | 3k2hA-3milA:undetectable | 3k2hA-3milA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nhz | TWO COMPONENT SYSTEMTRANSCRIPTIONALREGULATOR MTRA (Mycobacteriumtuberculosis) |
PF00072(Response_reg) | 5 | LEU A 112ARG A 115THR A 32ILE A 8LEU A 21 | None | 1.03A | 3k2hA-3nhzA:2.1 | 3k2hA-3nhzA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o47 | ADP-RIBOSYLATIONFACTORGTPASE-ACTIVATINGPROTEIN 1,ADP-RIBOSYLATIONFACTOR 1 (Homo sapiens) |
PF00025(Arf)PF01412(ArfGap) | 5 | LEU A 237ARG A 234ILE A 285LEU A 275LEU A 251 | None | 1.08A | 3k2hA-3o47A:undetectable | 3k2hA-3o47A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o5v | X-PRO DIPEPTIDASE (Streptococcuspyogenes) |
PF01321(Creatinase_N) | 5 | ALA A 99PHE A 43ILE A 115LEU A 89LEU A 18 | NoneNoneNoneNoneGOL A 132 ( 4.7A) | 1.09A | 3k2hA-3o5vA:undetectable | 3k2hA-3o5vA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q75 | FARNESYLTRANSFERASEBETA SUBUNIT (Cryptococcusneoformans) |
PF00432(Prenyltrans) | 5 | ALA B 151PHE B 93THR B 498LEU B 101LEU B 504 | None | 1.05A | 3k2hA-3q75B:undetectable | 3k2hA-3q75B:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qp5 | CVIR TRANSCRIPTIONALREGULATOR (Chromobacteriumviolaceum) |
PF00196(GerE)PF03472(Autoind_bind) | 5 | LEU A 40ARG A 74SER A 152LEU A 58LEU A 44 | None | 1.16A | 3k2hA-3qp5A:undetectable | 3k2hA-3qp5A:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rg9 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomabrucei) |
PF00186(DHFR_1) | 7 | ALA A 34ASP A 54ARG A 59THR A 86LEU A 97ARG A 100TYR A 166 | WRA A 602 (-3.9A)WRA A 602 (-2.9A)NoneNDP A 601 ( 3.2A)NoneNoneNone | 0.64A | 3k2hA-3rg9A:22.6 | 3k2hA-3rg9A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 6 | ALA A 8ASP A 28THR A 47ILE A 51LEU A 55ARG A 58 | MTX A2001 ( 3.4A)MTX A2001 (-2.7A)NDP A1001 (-3.1A)MTX A2001 (-4.3A)MTX A2001 ( 4.5A)MTX A2001 (-2.8A) | 0.64A | 3k2hA-3tq9A:22.0 | 3k2hA-3tq9A:17.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ASP A 54THR A 108LEU A 119ARG A 122TYR A 170 | 1CY A 609 (-2.9A)NDP A 610 ( 3.4A)NoneNoneNone | 0.55A | 3k2hA-3um6A:42.5 | 3k2hA-3um6A:44.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | THR A 108ILE A 112LEU A 119ARG A 122TYR A 170 | NDP A 610 ( 3.4A)1CY A 609 (-4.4A)NoneNoneNone | 0.69A | 3k2hA-3um6A:42.5 | 3k2hA-3um6A:44.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 7 | ALA A 8ASP A 28THR A 53ILE A 57LEU A 64ARG A 67TYR A 117 | NoneNoneSO4 A 201 (-3.7A)NoneNoneNoneNone | 0.55A | 3k2hA-3vcoA:20.9 | 3k2hA-3vcoA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a39 | METALLO-CARBOXYPEPTIDASE (Pseudomonasaeruginosa) |
PF00246(Peptidase_M14) | 5 | LEU A 364ARG A 186ILE A 181LEU A 184LEU A 201 | None | 1.09A | 3k2hA-4a39A:undetectable | 3k2hA-4a39A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5q | CHI1 (Yersiniaentomophaga) |
PF00704(Glyco_hydro_18) | 5 | ASP A 363ILE A 320SER A 297LEU A 322LEU A 480 | None | 1.16A | 3k2hA-4a5qA:undetectable | 3k2hA-4a5qA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8a | POLY(A) RIBONUCLEASEPOP2 (Saccharomycescerevisiae) |
PF04857(CAF1) | 5 | ASP B 199LEU B 200ILE B 207LEU B 261LEU B 232 | None | 0.91A | 3k2hA-4b8aB:undetectable | 3k2hA-4b8aB:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dn7 | ABC TRANSPORTER,ATP-BINDING PROTEIN (Methanosarcinamazei) |
PF01458(UPF0051) | 5 | ASP A 48LEU A 47THR A 178LEU A 72LEU A 55 | None | 1.12A | 3k2hA-4dn7A:undetectable | 3k2hA-4dn7A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f7z | RAP GUANINENUCLEOTIDE EXCHANGEFACTOR 4 (Mus musculus) |
PF00027(cNMP_binding)PF00610(DEP)PF00617(RasGEF)PF00618(RasGEF_N) | 6 | ALA A 85LEU A 135ARG A 137ILE A 68LEU A 70LEU A 88 | None | 1.22A | 3k2hA-4f7zA:undetectable | 3k2hA-4f7zA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fho | INTERNALIN C2 (Listeriamonocytogenes) |
PF12354(Internalin_N)PF12799(LRR_4)PF13516(LRR_6) | 5 | ALA A 205LEU A 226ILE A 220LEU A 237LEU A 213 | None | 1.14A | 3k2hA-4fhoA:undetectable | 3k2hA-4fhoA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8z | DIHYDROFOLATEREDUCTASE (Pneumocystisjirovecii) |
PF00186(DHFR_1) | 6 | ALA X 12THR X 61ILE X 65LEU X 72ARG X 75TYR X 129 | NDP X 302 ( 3.8A)NDP X 302 (-3.4A)TOP X 301 ( 4.3A)NoneNoneNone | 0.72A | 3k2hA-4g8zX:23.6 | 3k2hA-4g8zX:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h96 | DIHYDROFOLATEREDUCTASE (Candidaalbicans) |
PF00186(DHFR_1) | 6 | ALA A 11THR A 58ILE A 62LEU A 69ARG A 72TYR A 118 | 14Q A 202 ( 3.7A)NDP A 201 (-3.7A)14Q A 202 ( 4.8A)NoneNoneNone | 0.87A | 3k2hA-4h96A:20.3 | 3k2hA-4h96A:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h98 | DIHYDROFOLATEREDUCTASE ([Candida]glabrata) |
PF00186(DHFR_1) | 7 | ALA A 11ARG A 37THR A 58ILE A 62LEU A 69ARG A 72TYR A 127 | 14Q A 302 ( 3.4A)NoneNDP A 301 (-3.5A)14Q A 302 (-4.2A)NoneNoneNone | 0.75A | 3k2hA-4h98A:21.0 | 3k2hA-4h98A:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jej | GERANYLGERANYLGLYCERYL PHOSPHATESYNTHASE (Flavobacteriumjohnsoniae) |
PF01884(PcrB) | 5 | ASP A 39LEU A 38ILE A 53LEU A 28LEU A 68 | None | 1.16A | 3k2hA-4jejA:undetectable | 3k2hA-4jejA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m2x | DIHYDROFOLATEREDUCTASE (Mycobacteriumtuberculosis) |
PF00186(DHFR_1) | 7 | ALA A 7ASP A 27ARG A 32THR A 46LEU A 57ARG A 60TYR A 100 | TMQ A 202 ( 3.5A)TMQ A 202 ( 2.7A)NoneNDP A 201 (-3.4A)NoneNoneNone | 0.86A | 3k2hA-4m2xA:21.1 | 3k2hA-4m2xA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7v | DIHYDROFOLATEREDUCTASE (Enterococcusfaecalis) |
PF00186(DHFR_1) | 5 | ALA A 7ASP A 27THR A 46LEU A 55ARG A 58 | RAR A 200 ( 3.6A)RAR A 200 (-2.6A)NAP A 201 (-3.0A)RAR A 200 (-4.2A)RAR A 200 ( 3.2A) | 0.63A | 3k2hA-4m7vA:21.1 | 3k2hA-4m7vA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ozt | RETINOID X RECEPTOR (Pediculushumanus) |
PF00104(Hormone_recep) | 5 | ALA U 245LEU U 358ARG U 359ILE U 278LEU U 286 | None | 1.16A | 3k2hA-4oztU:undetectable | 3k2hA-4oztU:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 6 | ALA A 7ASP A 27THR A 46ILE A 50ARG A 57TYR A 100 | MTX A 201 ( 4.0A)MTX A 201 (-3.0A)NAP A 202 (-3.2A)MTX A 201 (-4.7A)MTX A 201 (-3.0A)None | 0.73A | 3k2hA-4p68A:21.7 | 3k2hA-4p68A:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4trb | PURINEPHOSPHORIBOSYLTRANSFERASE (GPT-1) (Sulfolobussolfataricus) |
PF00156(Pribosyltran) | 5 | PHE A 184LEU A 180ARG A 170LEU A 167LEU A 201 | None | 1.08A | 3k2hA-4trbA:undetectable | 3k2hA-4trbA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x28 | ACYL-COADEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ALA A 337PHE A 258LEU A 261ARG A 262LEU A 289 | None | 1.13A | 3k2hA-4x28A:undetectable | 3k2hA-4x28A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbr | PROTEINFAM212A,SERINE/THREONINE-PROTEIN KINASEPAK 4 (Homo sapiens) |
PF00069(Pkinase)PF15342(FAM212) | 5 | ALA A 463ILE A 441SER A 445LEU A 456LEU A 431 | SEP A 474 ( 4.1A)None MG A 603 ( 4.0A)NoneNone | 1.06A | 3k2hA-4xbrA:undetectable | 3k2hA-4xbrA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhc | ALPHA-L-RHAMNOSIDASE (Klebsiellaoxytoca) |
PF17389(Bac_rhamnosid6H) | 5 | ALA A 419LEU A 384LEU A 320ARG A 380LEU A 359 | None | 1.14A | 3k2hA-4xhcA:undetectable | 3k2hA-4xhcA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y2l | CFA/I FIMBRIALSUBUNIT B (Escherichiacoli) |
PF04449(Fimbrial_CS1) | 5 | ALA A 63LEU A 141ILE A 119LEU A 117LEU A 89 | None | 0.99A | 3k2hA-4y2lA:undetectable | 3k2hA-4y2lA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a65 | THIAMINETRIPHOSPHATASE (Mus musculus) |
PF01928(CYTH) | 5 | ALA A 87LEU A 64SER A 50LEU A 47LEU A 92 | None | 1.16A | 3k2hA-5a65A:undetectable | 3k2hA-5a65A:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b7i | CRISPR-ASSOCIATEDNUCLEASE/HELICASECAS3 SUBTYPEI-F/YPEST (Pseudomonasaeruginosa) |
no annotation | 5 | ALA A 552LEU A 309THR A 570LEU A 367LEU A 566 | None | 1.14A | 3k2hA-5b7iA:undetectable | 3k2hA-5b7iA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cml | OSMC FAMILY PROTEIN (Rhodothermusmarinus) |
PF12146(Hydrolase_4) | 5 | ALA A 117ARG A 141THR A 83LEU A 144LEU A 110 | None | 1.04A | 3k2hA-5cmlA:undetectable | 3k2hA-5cmlA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxv | RETHREADED DHFR (syntheticconstruct) |
PF00186(DHFR_1) | 5 | ALA A 6THR A 63ILE A 67LEU A 71ARG A 74 | NAP A 201 (-3.7A)NAP A 201 (-3.7A)PEG A 202 ( 4.9A)NoneNone | 1.10A | 3k2hA-5dxvA:13.1 | 3k2hA-5dxvA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxv | RETHREADED DHFR (syntheticconstruct) |
PF00186(DHFR_1) | 6 | ALA A 7THR A 63ILE A 67LEU A 71ARG A 74TYR A 117 | NAP A 201 (-3.7A)NAP A 201 (-3.7A)PEG A 202 ( 4.9A)NoneNoneNone | 0.63A | 3k2hA-5dxvA:13.1 | 3k2hA-5dxvA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fda | DIHYDROFOLATEREDUCTASE (Yersinia pestis) |
PF00186(DHFR_1) | 6 | ALA A 8THR A 47ILE A 51LEU A 55ARG A 58TYR A 101 | None | 1.09A | 3k2hA-5fdaA:14.9 | 3k2hA-5fdaA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j04 | ENOLASE (Synechococcuselongatus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ASP A 95LEU A 346ILE A 353LEU A 380LEU A 138 | None | 1.00A | 3k2hA-5j04A:undetectable | 3k2hA-5j04A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1l | TOXR-ACTIVATED GENE(TAGE) (Helicobacterpylori) |
PF01551(Peptidase_M23) | 5 | LEU B 135ILE B 293SER A 187LEU A 138LEU A 297 | None | 1.11A | 3k2hA-5j1lB:undetectable | 3k2hA-5j1lB:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN2NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4 (Bos taurus) |
PF00361(Proton_antipo_M)PF01059(Oxidored_q5_N)PF06444(NADH_dehy_S2_C) | 5 | ALA M 124PHE N 260LEU N 254THR M 153LEU M 150 | None | 1.16A | 3k2hA-5lc5M:undetectable | 3k2hA-5lc5M:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oc9 | - (-) |
no annotation | 5 | LEU A 23ILE A 143SER A 164LEU A 161LEU A 35 | None | 1.11A | 3k2hA-5oc9A:undetectable | 3k2hA-5oc9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | TFIIH BASALTRANSCRIPTION FACTORCOMPLEX HELICASE XPDSUBUNIT (Homo sapiens) |
PF06733(DEAD_2)PF06777(HBB)PF13307(Helicase_C_2) | 5 | LEU B 567ILE B 535SER B 528LEU B 524LEU B 597 | None | 1.15A | 3k2hA-5of4B:undetectable | 3k2hA-5of4B:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oqj | RNA POLYMERASE IITRANSCRIPTION FACTORB SUBUNIT 1 (Saccharomycescerevisiae) |
no annotation | 5 | ALA 1 50LEU 1 62ILE 1 16LEU 1 27LEU 1 104 | None | 1.12A | 3k2hA-5oqj1:undetectable | 3k2hA-5oqj1:11.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oqm | GENERALTRANSCRIPTION ANDDNA REPAIR FACTORIIH SUBUNIT TFB1 (Saccharomycescerevisiae) |
no annotation | 5 | ALA 1 50LEU 1 62ILE 1 16LEU 1 27LEU 1 104 | None | 1.12A | 3k2hA-5oqm1:undetectable | 3k2hA-5oqm1:11.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 7 | ALA A 10ASP A 31PHE A 32THR A 83LEU A 94ARG A 97TYR A 157 | 73X A 704 (-4.0A)73X A 704 (-2.8A)73X A 704 (-4.7A)NDP A 702 (-3.2A)NoneNoneNone | 0.37A | 3k2hA-5t0lA:45.9 | 3k2hA-5t0lA:42.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqd | DUMPY: SHORTER THANWILD-TYPE (Caenorhabditiselegans) |
no annotation | 5 | LEU A1227ARG A1276THR A1249ILE A1251LEU A1287 | NonePG0 A1704 (-3.8A)NoneNoneNone | 1.00A | 3k2hA-5uqdA:undetectable | 3k2hA-5uqdA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wc2 | PACHYTENE CHECKPOINTPROTEIN 2 HOMOLOG (Homo sapiens) |
no annotation | 5 | ASP A 285LEU A 281THR A 297ILE A 251LEU A 257 | None | 1.12A | 3k2hA-5wc2A:undetectable | 3k2hA-5wc2A:9.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wm9 | RV0078 (Mycobacteriumtuberculosis) |
no annotation | 5 | ALA A 166THR A 138ILE A 93LEU A 151LEU A 159 | ALA A 166 ( 0.0A)THR A 138 ( 0.8A)ILE A 93 ( 0.7A)LEU A 151 ( 0.6A)LEU A 159 ( 0.6A) | 1.13A | 3k2hA-5wm9A:undetectable | 3k2hA-5wm9A:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ws4 | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN MACB (Acinetobacterbaumannii) |
no annotation | 5 | ASP A 226LEU A 31THR A 198ILE A 200LEU A 56 | None | 1.08A | 3k2hA-5ws4A:undetectable | 3k2hA-5ws4A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk5 | UBIQUITIN LIGASE CBL (Salpingoecarosetta) |
no annotation | 5 | ALA A 243LEU A 276ILE A 211LEU A 281LEU A 228 | None | 1.13A | 3k2hA-6bk5A:undetectable | 3k2hA-6bk5A:11.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxm | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 6 | ALA A 8ASP A 28THR A 47LEU A 58ARG A 61TYR A 98 | NAP A 201 (-3.9A)MMV A 202 (-2.9A)NAP A 201 (-3.3A)MMV A 202 (-4.2A)MMV A 202 (-2.8A)None | 0.54A | 3k2hA-6cxmA:20.9 | 3k2hA-6cxmA:7.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dex | SUPPRESSOR OFHYDROXYUREASENSITIVITY PROTEIN2 (Eremotheciumgossypii) |
no annotation | 5 | ALA B 42PHE B 34LEU B 30THR B 166LEU B 15 | None | 1.14A | 3k2hA-6dexB:undetectable | 3k2hA-6dexB:10.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e4e | - (-) |
no annotation | 6 | ALA A 7ASP A 27THR A 46ILE A 50LEU A 54ARG A 57 | MMV A 202 ( 3.5A)MMV A 202 (-2.9A)NAP A 201 ( 3.3A)MMV A 202 ( 4.9A)NoneNone | 0.78A | 3k2hA-6e4eA:21.4 | 3k2hA-6e4eA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ezm | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (Saccharomycescerevisiae) |
no annotation | 5 | ALA U 170ILE U 200SER U 73LEU U 196LEU U 175 | None | 1.13A | 3k2hA-6ezmU:undetectable | 3k2hA-6ezmU:10.06 |