SIMILAR PATTERNS OF AMINO ACIDS FOR 3JZJ_A_ACRA405_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 THR A  71
ASN A 138
TRP A 134
TRP A 256
 None
 1.35A 3jzjA-1kgpA:
0.0		 3jzjA-1kgpA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1

(Homo sapiens) 		PF00397
(WW)
PF00639
(Rotamase) 		4 ASN A  17
TYR A  24
TRP A  11
TRP A  34
 None
None
None
1PE  A 300 (-3.6A)
 1.49A 3jzjA-1zcnA:
0.0		 3jzjA-1zcnA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		4 THR A  92
ASN A 329
TYR A 158
TRP A 343
 None
 1.43A 3jzjA-2ghbA:
19.0		 3jzjA-2ghbA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		4 THR A 278
ASN A 246
TYR A 258
TRP A 364
 None
 1.37A 3jzjA-3a5vA:
0.0		 3jzjA-3a5vA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 THR A  71
ASN A 138
TRP A 134
TRP A 256
 None
 1.29A 3jzjA-3mjoA:
0.0		 3jzjA-3mjoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 TRP A   9
TYR A 685
TRP A 694
TRP A 707
 EDO  A 816 (-4.9A)
None
None
None
 1.40A 3jzjA-4lgnA:
0.0		 3jzjA-4lgnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q88 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF07470
(Glyco_hydro_88) 		4 THR A 120
ASN A  85
TRP A  81
TRP A 228
 None
 1.29A 3jzjA-4q88A:
0.0		 3jzjA-4q88A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		4 ASN A 317
TRP A 316
TYR A 129
TRP A 128
 None
 1.43A 3jzjA-4uz1A:
0.0		 3jzjA-4uz1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm3 ENDOGLUCANASE-1

(Aspergillus
aculeatus) 		PF01670
(Glyco_hydro_12) 		4 THR A  49
ASN A  22
TYR A 100
TRP A  47
 None
 1.28A 3jzjA-5gm3A:
undetectable		 3jzjA-5gm3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlq CDPS

(Nocardia
brasiliensis) 		no annotation 4 ASN A  96
TRP A  92
TYR A 194
TRP A 220
 None
 1.35A 3jzjA-5mlqA:
undetectable		 3jzjA-5mlqA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noa FAMILY 88 GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		4 THR A 123
ASN A  88
TRP A  84
TRP A 231
 None
 1.19A 3jzjA-5noaA:
undetectable		 3jzjA-5noaA:
22.79