SIMILAR PATTERNS OF AMINO ACIDS FOR 3JZ0_B_CLYB900_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi) 		PF00150
(Cellulase) 		4 GLU A   3
TYR A  13
SER A 250
ILE A  55
 None
 1.09A 3jz0B-1egzA:
undetectable		 3jz0B-1egzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0t MOLT-INHIBITING
HORMONE

(Marsupenaeus
japonicus) 		PF01147
(Crust_neurohorm) 		4 GLU A  25
TYR A  17
PHE A  50
ILE A  52
 None
 1.00A 3jz0B-1j0tA:
undetectable		 3jz0B-1j0tA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 765
TYR A 861
PHE A 805
ILE A 804
 None
 1.07A 3jz0B-1kcwA:
0.0		 3jz0B-1kcwA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxq ANTIBODY VHH
FRAGMENT CABAMD9

(Camelus
dromedarius) 		PF07686
(V-set) 		4 GLU E 105
TYR E 107
TYR E  56
PHE E  34
 None
 1.06A 3jz0B-1kxqE:
undetectable		 3jz0B-1kxqE:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		4 TYR A  50
TYR A 139
SER A  55
ILE A  15
 None
 0.95A 3jz0B-1ldkA:
3.3		 3jz0B-1ldkA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nez H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, TLA(C)
ALPHA CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 152
TYR A  99
PHE A  73
SER A  69
 None
 1.06A 3jz0B-1nezA:
undetectable		 3jz0B-1nezA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbw PHOSPHATIDYLINOSITOL
3-KINASE

(Homo sapiens) 		PF00620
(RhoGAP) 		4 GLU A 140
TYR A 150
PHE A 268
ILE A 294
 None
 1.04A 3jz0B-1pbwA:
2.5		 3jz0B-1pbwA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbw PHOSPHATIDYLINOSITOL
3-KINASE

(Homo sapiens) 		PF00620
(RhoGAP) 		4 TYR A 150
GLU A 140
PHE A 268
ILE A 290
 None
 1.05A 3jz0B-1pbwA:
2.5		 3jz0B-1pbwA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		4 GLU A  27
TYR A  24
GLU A  28
ILE A 129
 None
 0.97A 3jz0B-1q5mA:
0.0		 3jz0B-1q5mA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986

(Pyrococcus
horikoshii) 		PF03746
(LamB_YcsF) 		4 GLU A 104
TYR A  95
PHE A 135
ILE A 132
 None
 1.07A 3jz0B-1v6tA:
undetectable		 3jz0B-1v6tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 GLU X 140
PHE X  66
SER X  64
ILE X  53
 None
 0.85A 3jz0B-1w52X:
0.4		 3jz0B-1w52X:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLU A 442
TYR A 370
GLU A 394
ILE A 518
 None
 1.05A 3jz0B-1yq2A:
0.0		 3jz0B-1yq2A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		4 TYR A  28
GLU A  33
PHE A  44
SER A  43
 None
 1.04A 3jz0B-1z7cA:
2.3		 3jz0B-1z7cA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg) 		4 TYR A  26
PHE A  46
SER A  74
ILE A  67
 None
 1.05A 3jz0B-1zitA:
undetectable		 3jz0B-1zitA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		4 GLU A  30
TYR A  70
GLU A  77
ILE A  37
 None
 0.99A 3jz0B-2fi1A:
undetectable		 3jz0B-2fi1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn4 UDP-GLCNAC C6
DEHYDRATASE

(Helicobacter
pylori) 		PF02719
(Polysacc_synt_2) 		4 GLU A  51
PHE A  63
SER A  43
ILE A  65
 None
None
NDP  A 334 (-3.8A)
None
 1.08A 3jz0B-2gn4A:
undetectable		 3jz0B-2gn4A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		4 GLU A  84
TYR A 201
PHE A 149
ILE A  97
 None
 1.00A 3jz0B-2hufA:
undetectable		 3jz0B-2hufA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kv1 METHIONINE-R-SULFOXI
DE REDUCTASE B1

(Mus musculus) 		PF01641
(SelR) 		4 TYR A  21
PHE A  46
SER A  35
ILE A  50
 None
 1.05A 3jz0B-2kv1A:
undetectable		 3jz0B-2kv1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nll PROTEIN (RETINOIC
ACID RECEPTOR)

(Homo sapiens) 		PF00105
(zf-C4) 		4 TYR A 192
TYR A 169
PHE A 158
ILE A 137
 None
 1.02A 3jz0B-2nllA:
undetectable		 3jz0B-2nllA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8p 14-3-3 DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		4 TYR A  39
GLU A  10
PHE A  48
SER A  46
 None
 1.07A 3jz0B-2o8pA:
4.4		 3jz0B-2o8pA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA

(-) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 331
GLU A 326
PHE A  34
ILE A  36
 None
 1.03A 3jz0B-2qgyA:
undetectable		 3jz0B-2qgyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkl SPAC19A8.12 PROTEIN

(Schizosaccharomyces
pombe) 		PF05026
(DCP2) 		4 GLU B  83
GLU B  84
SER B  79
ILE B  20
 None
 0.88A 3jz0B-2qklB:
undetectable		 3jz0B-2qklB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 TYR A 114
TYR A  94
GLU A 136
ILE A 466
 None
None
None
EDO  A 480 ( 4.3A)
 1.08A 3jz0B-2qneA:
undetectable		 3jz0B-2qneA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 TYR A 354
TYR A 239
SER A 360
ILE A 266
 None
 1.02A 3jz0B-2r66A:
undetectable		 3jz0B-2r66A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 TYR G 780
GLU G 784
PHE G 771
ILE G1077
 None
 1.01A 3jz0B-2uv8G:
1.1		 3jz0B-2uv8G:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy1 CLEAVAGE STIMULATION
FACTOR 77

(Encephalitozoon
cuniculi) 		PF05843
(Suf) 		4 TYR A  91
GLU A  95
TYR A  88
ILE A  54
 None
 0.73A 3jz0B-2uy1A:
undetectable		 3jz0B-2uy1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwa PUTATIVE
UNCHARACTERIZED
PROTEIN PF13_0012

(Plasmodium
falciparum) 		PF11567
(PfUIS3) 		4 TYR A 223
GLU A 227
TYR A 220
PHE A 167
 None
 0.86A 3jz0B-2vwaA:
2.7		 3jz0B-2vwaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 TYR A 323
GLU A 321
TYR A 345
ILE A 259
 None
 0.98A 3jz0B-2ww2A:
2.2		 3jz0B-2ww2A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens) 		PF05712
(MRG) 		4 TYR A 494
GLU A 493
SER A 212
ILE A 209
 None
 0.95A 3jz0B-2y0nA:
undetectable		 3jz0B-2y0nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9j PROTEIN PRGH

(Salmonella
enterica) 		PF09480
(PrgH) 		5 GLU A 304
TYR A 346
TYR A 354
PHE A 357
ILE A 327
 None
 1.50A 3jz0B-2y9jA:
undetectable		 3jz0B-2y9jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z13 EF-HAND
DOMAIN-CONTAINING
FAMILY MEMBER C2

(Homo sapiens) 		PF06565
(DUF1126) 		4 GLU A  23
GLU A  25
PHE A 102
ILE A 104
 None
 0.85A 3jz0B-2z13A:
undetectable		 3jz0B-2z13A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		5 GLU A  10
GLU A  14
PHE A   7
SER A 293
ILE A   5
 None
 1.25A 3jz0B-3bh1A:
undetectable		 3jz0B-3bh1A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c98 SYNTAXIN-1A

(Rattus
norvegicus) 		PF00804
(Syntaxin)
PF05739
(SNARE) 		4 GLU B 164
PHE B 177
SER B 179
ILE B 181
 None
 1.01A 3jz0B-3c98B:
undetectable		 3jz0B-3c98B:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TYR A 406
GLU A 303
SER A 334
ILE A 454
 None
 1.06A 3jz0B-3decA:
undetectable		 3jz0B-3decA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dn7 CYCLIC NUCLEOTIDE
BINDING REGULATORY
PROTEIN

(Cytophaga
hutchinsonii) 		PF00027
(cNMP_binding) 		4 TYR A 108
GLU A 112
SER A  80
ILE A  47
 None
 0.92A 3jz0B-3dn7A:
undetectable		 3jz0B-3dn7A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE

(Haemophilus
influenzae) 		PF03767
(Acid_phosphat_B) 		4 TYR A 178
GLU A 169
PHE A 213
ILE A 214
 None
 1.08A 3jz0B-3et5A:
undetectable		 3jz0B-3et5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f62 INTERLEUKIN 18
BINDING PROTEIN

(Ectromelia
virus) 		PF05566
(Pox_vIL-18BP) 		4 GLU A  77
GLU A  69
PHE A 108
ILE A  30
 None
 0.87A 3jz0B-3f62A:
undetectable		 3jz0B-3f62A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8h PUTATIVE POLYKETIDE
CYCLASE

(Ruegeria sp.
TM1040) 		PF12680
(SnoaL_2) 		4 TYR A  77
TYR A 120
GLU A  57
ILE A 113
 None
MRD  A 134 (-3.9A)
MRD  A 134 ( 2.7A)
None
 0.83A 3jz0B-3f8hA:
undetectable		 3jz0B-3f8hA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 TYR A1283
GLU A1273
PHE A1400
ILE A1425
 None
 1.05A 3jz0B-3fk2A:
undetectable		 3jz0B-3fk2A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwk METHYLCITRATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		4 TYR A  54
GLU A 206
TYR A 204
SER A 289
 None
 1.05A 3jz0B-3hwkA:
undetectable		 3jz0B-3hwkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0y PUTATIVE POLYKETIDE
CYCLASE

(Xanthomonas
campestris) 		PF12680
(SnoaL_2) 		4 TYR A  85
TYR A 128
GLU A  65
ILE A 121
 UNL  A 143 (-4.7A)
UNL  A 143 ( 4.2A)
UNL  A 143 (-2.1A)
None
 0.99A 3jz0B-3i0yA:
undetectable		 3jz0B-3i0yA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 GLU A 417
TYR A 386
SER A 411
ILE A 408
 NAG  A3830 ( 4.8A)
NAG  A3830 (-4.9A)
None
None
 1.09A 3jz0B-3i2tA:
undetectable		 3jz0B-3i2tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		4 TYR A 234
PHE A 268
SER A 265
ILE A 134
 None
 1.06A 3jz0B-3i7aA:
undetectable		 3jz0B-3i7aA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 173
TYR A 167
TYR A 158
PHE A  76
 None
 1.02A 3jz0B-3ip3A:
undetectable		 3jz0B-3ip3A:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jyy LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE

(Enterococcus
faecium) 		no annotation 7 TYR A  27
GLU A  42
TYR A  44
TYR A  75
GLU A  89
PHE A 104
ILE A 110
 None
MG  A 304 (-2.8A)
None
None
MG  A 304 (-3.1A)
None
None
 0.68A 3jz0B-3jyyA:
36.4		 3jz0B-3jyyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jyy LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE

(Enterococcus
faecium) 		no annotation 5 TYR A  44
TYR A  75
GLU A  89
PHE A 104
SER A 107
 None
None
MG  A 304 (-3.1A)
None
None
 1.25A 3jz0B-3jyyA:
36.4		 3jz0B-3jyyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		4 GLU A 155
TYR A 126
PHE A 163
ILE A 167
 None
 0.95A 3jz0B-3lcaA:
3.0		 3jz0B-3lcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		4 TYR A 186
GLU A  19
SER A 173
ILE A  91
 None
 0.98A 3jz0B-3mhpA:
undetectable		 3jz0B-3mhpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obe SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 TYR A 261
TYR A 224
PHE A 265
ILE A 294
 None
 0.96A 3jz0B-3obeA:
undetectable		 3jz0B-3obeA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omb EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 TYR A 159
GLU A 439
PHE A 382
ILE A 390
 None
 0.99A 3jz0B-3ombA:
undetectable		 3jz0B-3ombA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1w RABGDI PROTEIN

(Plasmodium
falciparum) 		PF00996
(GDI) 		4 TYR A 220
GLU A 133
PHE A 232
ILE A 233
 None
 0.95A 3jz0B-3p1wA:
undetectable		 3jz0B-3p1wA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN

(Chloroflexus
aurantiacus) 		PF13560
(HTH_31) 		4 TYR A 258
TYR A 239
PHE A 130
ILE A 126
 MYR  A 301 (-4.5A)
None
None
None
 1.02A 3jz0B-3pxpA:
undetectable		 3jz0B-3pxpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 TYR A 128
GLU A 131
PHE A  39
ILE A 121
 None
 0.95A 3jz0B-3q1oA:
2.7		 3jz0B-3q1oA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q46 TT-IPPASE

(Thermococcus
thioreducens) 		PF00719
(Pyrophosphatase) 		4 TYR A  52
GLU A  32
PHE A 136
ILE A 150
 None
MG  A 308 ( 2.6A)
None
None
 1.07A 3jz0B-3q46A:
undetectable		 3jz0B-3q46A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 TYR A 314
GLU A 318
TYR A  17
ILE A  47
 None
 1.09A 3jz0B-3qgvA:
undetectable		 3jz0B-3qgvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 234
TYR A 172
GLU A 260
ILE A 225
 MG  A 500 (-3.0A)
None
MG  A 500 (-2.6A)
None
 0.80A 3jz0B-3rcyA:
undetectable		 3jz0B-3rcyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 234
TYR A 172
GLU A 260
ILE A 225
 None
 0.79A 3jz0B-3t4wA:
undetectable		 3jz0B-3t4wA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 TYR A1205
TYR A1172
PHE A1214
ILE A1094
 None
 1.02A 3jz0B-3topA:
undetectable		 3jz0B-3topA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 GLU A 205
GLU A 209
SER A  93
ILE A 199
 None
 0.99A 3jz0B-3tsdA:
undetectable		 3jz0B-3tsdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP

(Bacillus
subtilis) 		PF00494
(SQS_PSY) 		5 TYR A 115
GLU A 120
TYR A 124
PHE A 164
ILE A 208
 None
 1.22A 3jz0B-3we9A:
2.0		 3jz0B-3we9A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 4 TYR A 612
PHE A 513
SER A 248
ILE A 451
 None
 1.03A 3jz0B-3wevA:
undetectable		 3jz0B-3wevA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 GLU A 273
TYR A  91
GLU A 194
ILE A 536
 FEO  A1595 ( 2.4A)
None
FEO  A1595 ( 2.5A)
None
 0.94A 3jz0B-4amfA:
undetectable		 3jz0B-4amfA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 TYR A 188
TYR A 206
GLU A 183
SER A 303
 None
 0.98A 3jz0B-4azvA:
undetectable		 3jz0B-4azvA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 TYR A 188
TYR A 206
GLU A 183
SER A 303
 None
 1.03A 3jz0B-4azwA:
undetectable		 3jz0B-4azwA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbv COME

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF04397
(LytTR) 		4 TYR A  55
TYR A  78
PHE A  42
ILE A  61
 None
 0.87A 3jz0B-4cbvA:
undetectable		 3jz0B-4cbvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		4 GLU A 345
TYR A 349
PHE A 246
SER A 274
 None
 1.02A 3jz0B-4ep0A:
undetectable		 3jz0B-4ep0A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evm THIOREDOXIN FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00578
(AhpC-TSA) 		4 GLU A 148
TYR A 150
PHE A  79
SER A 112
 None
 1.03A 3jz0B-4evmA:
undetectable		 3jz0B-4evmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h96 DIHYDROFOLATE
REDUCTASE

(Candida
albicans) 		PF00186
(DHFR_1) 		4 TYR A 186
TYR A 184
GLU A 174
ILE A   9
 None
None
None
14Q  A 202 (-4.3A)
 0.98A 3jz0B-4h96A:
undetectable		 3jz0B-4h96A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuy SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE

(Acinetobacter
baumannii) 		PF00106
(adh_short) 		4 TYR A  61
TYR A  10
GLU A  83
ILE A  52
 None
 0.92A 3jz0B-4iuyA:
undetectable		 3jz0B-4iuyA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 235
TYR A 173
GLU A 261
ILE A 226
 None
 0.79A 3jz0B-4j3zA:
undetectable		 3jz0B-4j3zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7o PUTATIVE SURFACE
CELL ANTIGEN SCA2

(Rickettsia
conorii) 		no annotation 4 TYR A 321
TYR A 320
GLU A 336
ILE A 355
 None
 0.91A 3jz0B-4j7oA:
undetectable		 3jz0B-4j7oA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9a ACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A  69
TYR A  66
SER A  62
ILE A  12
 None
 1.07A 3jz0B-4m9aA:
3.4		 3jz0B-4m9aA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		4 TYR A 191
TYR A 195
GLU A 151
ILE A  70
 G3P  A 407 (-3.4A)
None
None
None
 0.91A 3jz0B-4pfbA:
undetectable		 3jz0B-4pfbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		4 TYR A 439
TYR A 399
PHE A 382
ILE A   4
 None
 1.06A 3jz0B-4ptxA:
undetectable		 3jz0B-4ptxA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 TYR A  82
GLU A  78
GLU A 143
ILE A  21
 ACT  A 703 (-4.8A)
None
None
None
 0.89A 3jz0B-4qjyA:
3.6		 3jz0B-4qjyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r03 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12930
(DUF3836) 		4 GLU A  73
TYR A  94
TYR A 107
ILE A  42
 None
 1.07A 3jz0B-4r03A:
undetectable		 3jz0B-4r03A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		4 TYR A 333
GLU A 315
PHE A 340
ILE A 342
 None
 0.85A 3jz0B-4u6bA:
undetectable		 3jz0B-4u6bA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyb SEC14-LIKE PROTEIN 3

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 TYR A 294
GLU A 293
PHE A 316
ILE A 314
 None
 1.07A 3jz0B-4uybA:
undetectable		 3jz0B-4uybA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		4 GLU A  25
GLU A  22
SER A  70
ILE A 120
 None
 1.00A 3jz0B-4xniA:
undetectable		 3jz0B-4xniA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		4 GLU A 373
TYR A 360
SER A 134
ILE A 130
 None
 1.04A 3jz0B-4y7iA:
undetectable		 3jz0B-4y7iA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3i STAPHYLOCOCCAL
SUPERANTIGEN-LIKE
PROTEIN 3

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 TYR B 214
GLU B 205
TYR B 209
PHE B 168
 None
 0.85A 3jz0B-5d3iB:
undetectable		 3jz0B-5d3iB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLU A  87
TYR A 241
SER A 218
ILE A 220
 None
 1.04A 3jz0B-5f9sA:
undetectable		 3jz0B-5f9sA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		4 GLU A 263
PHE A  32
SER A  91
ILE A   9
 None
 1.09A 3jz0B-5gw7A:
4.0		 3jz0B-5gw7A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		4 TYR A 383
TYR A 382
SER A 320
ILE A 347
 None
 0.90A 3jz0B-5hasA:
1.5		 3jz0B-5hasA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		4 TYR A 746
GLU A 463
TYR A 747
ILE A 406
 None
 1.02A 3jz0B-5hb3A:
2.7		 3jz0B-5hb3A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jja SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 TYR A 263
TYR A 292
PHE A 211
ILE A 207
 TYR  A 263 ( 1.3A)
TYR  A 292 ( 1.3A)
PHE  A 211 ( 1.3A)
ILE  A 207 ( 0.7A)
 1.06A 3jz0B-5jjaA:
2.1		 3jz0B-5jjaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 TYR A  39
GLU A 377
SER A 316
ILE A 305
 None
 1.07A 3jz0B-5kf7A:
undetectable		 3jz0B-5kf7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 TYR A 179
GLU A 198
SER A 155
ILE A 501
 None
 0.94A 3jz0B-5l8sA:
undetectable		 3jz0B-5l8sA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 TYR A 453
GLU A 161
PHE A 364
ILE A 366
 None
 1.07A 3jz0B-5lv9A:
undetectable		 3jz0B-5lv9A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 GLU A 795
TYR A 773
PHE A 767
SER A 800
 None
 0.86A 3jz0B-5nn8A:
undetectable		 3jz0B-5nn8A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 4 TYR A 212
GLU A 157
SER A 122
ILE A 227
 EDO  A 603 (-3.8A)
None
None
None
 1.07A 3jz0B-5nzgA:
undetectable		 3jz0B-5nzgA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		4 TYR A 486
TYR A 426
GLU A 422
ILE A 461
 None
 1.00A 3jz0B-5odrA:
undetectable		 3jz0B-5odrA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 4 GLU A 421
TYR A 471
PHE A 307
ILE A 340
 None
 1.05A 3jz0B-5uj1A:
undetectable		 3jz0B-5uj1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 TYR A  81
GLU A 171
PHE A  59
ILE A  38
 None
MG  A 906 ( 3.9A)
None
None
 1.07A 3jz0B-5v9xA:
undetectable		 3jz0B-5v9xA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 GLU A 446
TYR A 437
PHE A 449
SER A 301
 None
 0.73A 3jz0B-5xb7A:
undetectable		 3jz0B-5xb7A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d72 SPERMIDINE
N1-ACETYLTRANSFERASE

(Yersinia pestis) 		no annotation 4 GLU A 109
TYR A 110
PHE A  60
ILE A  62
 None
 1.09A 3jz0B-6d72A:
undetectable		 3jz0B-6d72A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d85 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA

(Bos taurus) 		no annotation 4 GLU B 140
TYR B 150
PHE B 268
ILE B 294
 None
 0.96A 3jz0B-6d85B:
undetectable		 3jz0B-6d85B:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLU A 680
GLU A 678
PHE A 660
ILE A 748
 None
CA  A 802 (-3.4A)
None
None
 1.05A 3jz0B-6eonA:
undetectable		 3jz0B-6eonA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 4 GLU A  36
GLU A  33
SER A  81
ILE A 131
 None
None
OLC  A 502 (-4.5A)
None
 1.08A 3jz0B-6exsA:
2.6		 3jz0B-6exsA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Saccharomyces
cerevisiae) 		no annotation 4 GLU G 153
TYR G 194
PHE G  77
ILE G   3
 None
 1.02A 3jz0B-6f42G:
undetectable		 3jz0B-6f42G:
13.54