SIMILAR PATTERNS OF AMINO ACIDS FOR 3JZ0_A_CLYA900

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF00022
(Actin)
PF04045
(P34-Arc) 		5 GLU A 104
HIS D 252
PHE D 247
ILE D 244
MET D 152
 None
 1.49A 3jz0A-1u2vA:
0.0		 3jz0A-1u2vA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		5 GLU A  10
GLU A  14
PHE A   7
SER A 293
ILE A   5
 None
 1.28A 3jz0A-3bh1A:
0.0		 3jz0A-3bh1A:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jyy LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE

(Enterococcus
faecium) 		no annotation 9 TYR A  27
GLU A  42
TYR A  44
TYR A  75
GLU A  89
HIS A  91
PHE A 104
ILE A 110
MET A 116
 None
MG  A 304 (-2.8A)
None
None
MG  A 304 (-3.1A)
None
None
None
None
 0.56A 3jz0A-3jyyA:
37.3		 3jz0A-3jyyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jyy LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE

(Enterococcus
faecium) 		no annotation 6 TYR A  27
TYR A  44
TYR A  75
HIS A  91
ILE A 132
MET A 116
 None
 1.35A 3jz0A-3jyyA:
37.3		 3jz0A-3jyyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jyy LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE

(Enterococcus
faecium) 		no annotation 6 TYR A  44
TYR A  75
GLU A  89
HIS A  91
PHE A 104
SER A 107
 None
None
MG  A 304 (-3.1A)
None
None
None
 1.11A 3jz0A-3jyyA:
37.3		 3jz0A-3jyyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP

(Bacillus
subtilis) 		PF00494
(SQS_PSY) 		5 TYR A 115
GLU A 120
TYR A 124
PHE A 164
ILE A 208
 None
 1.17A 3jz0A-3we9A:
0.0		 3jz0A-3we9A:
23.25