SIMILAR PATTERNS OF AMINO ACIDS FOR 3JX5_A_H4BA760

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN

(Tobacco
ringspot virus) 		PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N) 		4 VAL A 496
ARG A 482
VAL A 390
PHE A 374
 None
 1.25A 3jx5A-1a6cA:
0.0
3jx5B-1a6cA:
0.0		 3jx5A-1a6cA:
20.38
3jx5B-1a6cA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 VAL A 326
ARG A 219
VAL A 209
PHE A 222
 None
 1.12A 3jx5A-1b41A:
0.0
3jx5B-1b41A:
0.0		 3jx5A-1b41A:
20.61
3jx5B-1b41A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 VAL A 326
ARG A 219
VAL A 209
PHE A 222
 None
 1.01A 3jx5A-1c2oA:
0.0
3jx5B-1c2oA:
0.0		 3jx5A-1c2oA:
20.04
3jx5B-1c2oA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccz PROTEIN (CD58)

(Homo sapiens) 		PF05790
(C2-set) 		4 VAL A  92
ARG A  52
VAL A  13
GLU A  72
 None
 0.97A 3jx5A-1cczA:
0.0
3jx5B-1cczA:
0.0		 3jx5A-1cczA:
17.72
3jx5B-1cczA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.20A 3jx5A-1edzA:
0.0
3jx5B-1edzA:
0.7		 3jx5A-1edzA:
22.27
3jx5B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqo URE2 PROTEIN

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.00A 3jx5A-1hqoA:
0.0
3jx5B-1hqoA:
0.5		 3jx5A-1hqoA:
19.28
3jx5B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 VAL L 108
ARG L  63
VAL L  18
GLU L  85
 None
 1.26A 3jx5A-1mfaL:
0.0
3jx5B-1mfaL:
0.0		 3jx5A-1mfaL:
14.22
3jx5B-1mfaL:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN

(Pseudomonas
aeruginosa) 		PF01475
(FUR) 		4 ARG A  69
VAL A  54
PHE A  79
GLU A  36
 None
 1.04A 3jx5A-1mzbA:
0.2
3jx5B-1mzbA:
0.3		 3jx5A-1mzbA:
16.59
3jx5B-1mzbA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL E 106
ARG E  61
VAL E  19
GLU E  83
 None
 1.04A 3jx5A-1nfdE:
0.0
3jx5B-1nfdE:
0.0		 3jx5A-1nfdE:
18.93
3jx5B-1nfdE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		4 VAL A 200
ARG A 160
TRP A  27
PHE A 154
 None
None
SO4  A 400 (-3.4A)
SO4  A 400 (-4.6A)
 1.27A 3jx5A-1nrkA:
undetectable
3jx5B-1nrkA:
undetectable		 3jx5A-1nrkA:
20.92
3jx5B-1nrkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.89A 3jx5A-1pw3A:
undetectable
3jx5B-1pw3A:
undetectable		 3jx5A-1pw3A:
13.95
3jx5B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		4 ARG B 156
VAL B 128
PHE B 163
GLU B  26
 None
 1.16A 3jx5A-1wqlB:
undetectable
3jx5B-1wqlB:
undetectable		 3jx5A-1wqlB:
19.79
3jx5B-1wqlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xn6 HYPOTHETICAL PROTEIN
BC4709

(Bacillus cereus) 		PF08327
(AHSA1) 		4 VAL A  27
VAL A 140
TRP A  36
PHE A  16
 None
 1.01A 3jx5A-1xn6A:
undetectable
3jx5B-1xn6A:
undetectable		 3jx5A-1xn6A:
15.33
3jx5B-1xn6A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9m GAPA225

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 136
ARG A  92
VAL A  56
GLU A 115
 None
 1.13A 3jx5A-1z9mA:
undetectable
3jx5B-1z9mA:
undetectable		 3jx5A-1z9mA:
17.61
3jx5B-1z9mA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9m FLUORESCEIN-SCFV
LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 VAL L 147
ARG L  77
VAL L  19
GLU L 101
 None
 1.00A 3jx5A-2a9mL:
undetectable
3jx5B-2a9mL:
undetectable		 3jx5A-2a9mL:
13.74
3jx5B-2a9mL:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ARG A 708
VAL A1424
PHE A 722
GLU A 693
 None
 1.11A 3jx5A-2b39A:
undetectable
3jx5B-2b39A:
undetectable		 3jx5A-2b39A:
13.74
3jx5B-2b39A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 VAL A 326
VAL A 294
PHE A 321
GLU A 327
 None
 1.20A 3jx5A-2d4eA:
undetectable
3jx5B-2d4eA:
undetectable		 3jx5A-2d4eA:
23.19
3jx5B-2d4eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		4 ARG A 202
TRP A  93
PHE A  99
GLU A 101
 GUN  A 503 (-3.7A)
None
None
None
 1.25A 3jx5A-2i9uA:
undetectable
3jx5B-2i9uA:
0.4		 3jx5A-2i9uA:
21.17
3jx5B-2i9uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 VAL A  23
ARG A 116
PHE A  29
GLU A  27
 None
 1.17A 3jx5A-2incA:
undetectable
3jx5B-2incA:
undetectable		 3jx5A-2incA:
21.48
3jx5B-2incA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvo NUCLEOLAR PROTEIN 3

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 VAL A  43
VAL A  61
PHE A  52
GLU A  47
 None
 1.11A 3jx5A-2jvoA:
undetectable
3jx5B-2jvoA:
undetectable		 3jx5A-2jvoA:
13.56
3jx5B-2jvoA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxf PUTATIVE DIMETAL
PHOSPHATASE

(Danio rerio) 		PF00149
(Metallophos) 		4 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 3jx5A-2nxfA:
undetectable
3jx5B-2nxfA:
0.4		 3jx5A-2nxfA:
22.59
3jx5B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or8 HEPATITIS A VIRUS
CELLULAR RECEPTOR 1
HOMOLOG

(Mus musculus) 		PF07686
(V-set) 		4 VAL A  81
ARG A  34
VAL A  15
GLU A  82
 None
 1.23A 3jx5A-2or8A:
undetectable
3jx5B-2or8A:
undetectable		 3jx5A-2or8A:
14.64
3jx5B-2or8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot9 HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF07152
(YaeQ) 		4 VAL A 152
ARG A 179
VAL A 170
PHE A  49
 None
 1.20A 3jx5A-2ot9A:
undetectable
3jx5B-2ot9A:
undetectable		 3jx5A-2ot9A:
19.07
3jx5B-2ot9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhe BENCE-JONES PROTEIN
RHE (LIGHT CHAIN)

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 1.08A 3jx5A-2rheA:
undetectable
3jx5B-2rheA:
undetectable		 3jx5A-2rheA:
14.77
3jx5B-2rheA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtt CHIC

(Streptomyces
coelicolor) 		PF00553
(CBM_2) 		4 VAL A  37
VAL A  55
PHE A  41
GLU A  38
 None
 1.26A 3jx5A-2rttA:
undetectable
3jx5B-2rttA:
undetectable		 3jx5A-2rttA:
15.95
3jx5B-2rttA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Pyrobaculum
calidifontis) 		PF01370
(Epimerase) 		4 VAL A 206
VAL A 228
TRP A 285
GLU A 207
 None
 1.22A 3jx5A-3aw9A:
undetectable
3jx5B-3aw9A:
undetectable		 3jx5A-3aw9A:
20.51
3jx5B-3aw9A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 1.19A 3jx5A-3bjlA:
undetectable
3jx5B-3bjlA:
undetectable		 3jx5A-3bjlA:
21.09
3jx5B-3bjlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9u HEME OXYGENASE 1

(Rattus
norvegicus) 		PF01126
(Heme_oxygenase) 		4 VAL A  73
ARG A 198
VAL A 130
GLU A 190
 None
 1.26A 3jx5A-3i9uA:
undetectable
3jx5B-3i9uA:
undetectable		 3jx5A-3i9uA:
20.51
3jx5B-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy4 FRAGMENT OF
NEUTRALIZING
ANTIBODY 15 (HEAVY
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 VAL B 221
ARG B 172
VAL B 123
PHE B 173
 None
 1.17A 3jx5A-3iy4B:
undetectable
3jx5B-3iy4B:
undetectable		 3jx5A-3iy4B:
13.03
3jx5B-3iy4B:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		PF01381
(HTH_3) 		4 VAL A 114
VAL A 105
PHE A  65
GLU A 118
 None
 0.99A 3jx5A-3kxaA:
undetectable
3jx5B-3kxaA:
undetectable		 3jx5A-3kxaA:
17.40
3jx5B-3kxaA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrh ANTI-HUNTINGTIN VL
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.92A 3jx5A-3lrhA:
undetectable
3jx5B-3lrhA:
undetectable		 3jx5A-3lrhA:
17.01
3jx5B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mj9 JUNCTIONAL ADHESION
MOLECULE-LIKE

(Mus musculus) 		PF07686
(V-set) 		4 VAL A 118
ARG A  70
VAL A  21
GLU A  94
 None
 1.10A 3jx5A-3mj9A:
undetectable
3jx5B-3mj9A:
undetectable		 3jx5A-3mj9A:
21.26
3jx5B-3mj9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 ARG A 175
VAL A  92
PHE A 121
GLU A 119
 None
 1.23A 3jx5A-3owcA:
undetectable
3jx5B-3owcA:
1.7		 3jx5A-3owcA:
16.71
3jx5B-3owcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p30 1281 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.82A 3jx5A-3p30L:
undetectable
3jx5B-3p30L:
undetectable		 3jx5A-3p30L:
19.95
3jx5B-3p30L:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qaw RHO-CLASS
GLUTATHIONE
S-TRANSFERASE

(Laternula
elliptica) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 VAL A  85
ARG A 199
VAL A  24
PHE A 161
 None
 1.18A 3jx5A-3qawA:
undetectable
3jx5B-3qawA:
undetectable		 3jx5A-3qawA:
20.19
3jx5B-3qawA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4z GLYCOSYL HYDROLASE
FAMILY 32, N
TERMINAL

(Saccharophagus
degradans) 		PF04616
(Glyco_hydro_43) 		4 VAL A 130
VAL A  94
TRP A  66
GLU A 129
 None
 1.26A 3jx5A-3r4zA:
undetectable
3jx5B-3r4zA:
undetectable		 3jx5A-3r4zA:
20.59
3jx5B-3r4zA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL K 108
ARG K  63
VAL K  18
GLU K  85
 None
 1.18A 3jx5A-3ri5K:
undetectable
3jx5B-3ri5K:
undetectable		 3jx5A-3ri5K:
19.19
3jx5B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 VAL A 213
ARG A 199
VAL A 192
GLU A 217
 None
 1.04A 3jx5A-3rr5A:
undetectable
3jx5B-3rr5A:
undetectable		 3jx5A-3rr5A:
20.64
3jx5B-3rr5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 0.87A 3jx5A-3t2nL:
undetectable
3jx5B-3t2nL:
undetectable		 3jx5A-3t2nL:
20.15
3jx5B-3t2nL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Coxiella
burnetii) 		PF01725
(Ham1p_like) 		4 VAL A 162
TRP A 140
PHE A 118
GLU A 141
 None
 1.25A 3jx5A-3tquA:
undetectable
3jx5B-3tquA:
undetectable		 3jx5A-3tquA:
17.25
3jx5B-3tquA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux9 SCFV ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		4 VAL B 111
ARG B  64
VAL B  20
GLU B  86
 None
 1.11A 3jx5A-3ux9B:
undetectable
3jx5B-3ux9B:
undetectable		 3jx5A-3ux9B:
21.18
3jx5B-3ux9B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv4 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		4 VAL A  72
TRP A  71
PHE A  67
GLU A  73
 None
PVG  A 201 (-3.6A)
None
None
 1.06A 3jx5A-3vv4A:
undetectable
3jx5B-3vv4A:
0.4		 3jx5A-3vv4A:
19.24
3jx5B-3vv4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 108
ARG L  62
VAL L  18
GLU L  84
 None
 1.04A 3jx5A-3zl4L:
undetectable
3jx5B-3zl4L:
undetectable		 3jx5A-3zl4L:
19.53
3jx5B-3zl4L:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.10A 3jx5A-4b90A:
undetectable
3jx5B-4b90A:
0.2		 3jx5A-4b90A:
20.09
3jx5B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.12A 3jx5A-4b92A:
undetectable
3jx5B-4b92A:
undetectable		 3jx5A-4b92A:
22.16
3jx5B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		4 VAL A 347
VAL A 350
PHE A 360
GLU A 335
 None
 1.18A 3jx5A-4de8A:
undetectable
3jx5B-4de8A:
2.0		 3jx5A-4de8A:
22.32
3jx5B-4de8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfi POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 128
ARG A  72
VAL A  20
GLU A 105
 None
 1.06A 3jx5A-4dfiA:
undetectable
3jx5B-4dfiA:
undetectable		 3jx5A-4dfiA:
14.76
3jx5B-4dfiA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 VAL A 214
ARG A 200
VAL A 193
GLU A 218
 None
 0.86A 3jx5A-4eq5A:
undetectable
3jx5B-4eq5A:
undetectable		 3jx5A-4eq5A:
20.71
3jx5B-4eq5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmf POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 1

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 VAL A 142
ARG A  96
VAL A  47
GLU A 119
 None
 1.05A 3jx5A-4fmfA:
undetectable
3jx5B-4fmfA:
undetectable		 3jx5A-4fmfA:
21.40
3jx5B-4fmfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2

(Mus musculus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 VAL A 149
ARG A  97
VAL A  50
GLU A 126
 None
 1.02A 3jx5A-4fmkA:
undetectable
3jx5B-4fmkA:
undetectable		 3jx5A-4fmkA:
22.04
3jx5B-4fmkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glr ANTI-PTAU LIGHT
CHAIN

(Gallus gallus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL I 106
ARG I  61
VAL I  19
GLU I  83
 None
 1.18A 3jx5A-4glrI:
undetectable
3jx5B-4glrI:
undetectable		 3jx5A-4glrI:
19.08
3jx5B-4glrI:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 1.26A 3jx5A-4k3gA:
undetectable
3jx5B-4k3gA:
undetectable		 3jx5A-4k3gA:
14.86
3jx5B-4k3gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 VAL B 351
TRP B 355
PHE B 327
GLU B 424
 None
 0.97A 3jx5A-4l37B:
undetectable
3jx5B-4l37B:
undetectable		 3jx5A-4l37B:
20.83
3jx5B-4l37B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l95 GAMMA-GLUTAMYL
HYDROLASE

(Danio rerio) 		no annotation 4 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.08A 3jx5A-4l95E:
undetectable
3jx5B-4l95E:
undetectable		 3jx5A-4l95E:
19.10
3jx5B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2x DIHYDROFOLATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF00186
(DHFR_1) 		4 VAL A  79
ARG A  61
VAL A  41
GLU A  84
 None
 1.22A 3jx5A-4m2xA:
undetectable
3jx5B-4m2xA:
undetectable		 3jx5A-4m2xA:
17.09
3jx5B-4m2xA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6x ANKYRIN-3

(Homo sapiens) 		PF00531
(Death) 		4 VAL A  71
ARG A  58
PHE A  28
GLU A  25
 None
 1.10A 3jx5A-4o6xA:
undetectable
3jx5B-4o6xA:
undetectable		 3jx5A-4o6xA:
14.69
3jx5B-4o6xA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9h LIGHT CHAIN OF THE
CAMELID FAB FRAGMENT
61H7

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 108
ARG L  63
VAL L  18
GLU L  85
 None
 1.24A 3jx5A-4o9hL:
undetectable
3jx5B-4o9hL:
undetectable		 3jx5A-4o9hL:
20.15
3jx5B-4o9hL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouo ANTI BLA G 1 SCFV

(Gallus gallus) 		PF07686
(V-set) 		4 VAL A 106
ARG A  60
VAL A  18
GLU A  82
 None
 1.17A 3jx5A-4ouoA:
undetectable
3jx5B-4ouoA:
undetectable		 3jx5A-4ouoA:
20.28
3jx5B-4ouoA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p49 ANTIBODY SCFV B8

(Gallus gallus) 		PF07686
(V-set) 		4 VAL A 101
ARG A  56
VAL A  16
GLU A  78
 None
 1.26A 3jx5A-4p49A:
undetectable
3jx5B-4p49A:
undetectable		 3jx5A-4p49A:
21.78
3jx5B-4p49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 4 VAL A 264
VAL A 255
PHE A 273
GLU A 268
 None
 1.22A 3jx5A-4p5wA:
undetectable
3jx5B-4p5wA:
undetectable		 3jx5A-4p5wA:
20.91
3jx5B-4p5wA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnr PGT130 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.06A 3jx5A-4rnrB:
undetectable
3jx5B-4rnrB:
undetectable		 3jx5A-4rnrB:
19.39
3jx5B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3v POLYKETIDE SYNTHASE
PKSR

(Bacillus
subtilis) 		PF14765
(PS-DH) 		4 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 3jx5A-4u3vA:
undetectable
3jx5B-4u3vA:
undetectable		 3jx5A-4u3vA:
20.81
3jx5B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unu IG LAMBDA CHAIN V-II
REGION MGC

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 109
ARG A  63
VAL A  18
GLU A  85
 None
 1.01A 3jx5A-4unuA:
undetectable
3jx5B-4unuA:
undetectable		 3jx5A-4unuA:
13.92
3jx5B-4unuA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 VAL E 248
ARG E 201
VAL E 157
GLU E 223
 None
 1.06A 3jx5A-4v1dE:
undetectable
3jx5B-4v1dE:
undetectable		 3jx5A-4v1dE:
14.76
3jx5B-4v1dE:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE

(Vibrio cholerae) 		no annotation 4 ARG A 280
VAL A 309
TRP A 267
PHE A 268
 None
 1.16A 3jx5A-4xj5A:
undetectable
3jx5B-4xj5A:
undetectable		 3jx5A-4xj5A:
20.61
3jx5B-4xj5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 ARG A 276
VAL A 305
PHE A 264
GLU A 266
 None
 1.09A 3jx5A-4xj6A:
undetectable
3jx5B-4xj6A:
1.5		 3jx5A-4xj6A:
21.06
3jx5B-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 VAL A 305
TRP A 263
PHE A 264
GLU A 266
 None
 1.11A 3jx5A-4xj6A:
undetectable
3jx5B-4xj6A:
1.5		 3jx5A-4xj6A:
21.06
3jx5B-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5x DIABODY 310 VH
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 VAL B 109
ARG B  62
VAL B  18
GLU B  84
 None
 0.90A 3jx5A-4y5xB:
undetectable
3jx5B-4y5xB:
undetectable		 3jx5A-4y5xB:
14.45
3jx5B-4y5xB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		4 VAL C 335
VAL C 511
TRP C 550
GLU C 338
 None
 1.15A 3jx5A-4yfaC:
undetectable
3jx5B-4yfaC:
undetectable		 3jx5A-4yfaC:
21.42
3jx5B-4yfaC:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		4 VAL A 299
VAL A 147
TRP A  72
PHE A  64
 None
 1.26A 3jx5A-4yhsA:
undetectable
3jx5B-4yhsA:
undetectable		 3jx5A-4yhsA:
22.92
3jx5B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjz SCFV H2526

(Homo sapiens) 		PF07686
(V-set) 		4 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 1.12A 3jx5A-4yjzL:
undetectable
3jx5B-4yjzL:
undetectable		 3jx5A-4yjzL:
21.74
3jx5B-4yjzL:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 LIGHT CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 109
ARG L  63
VAL L  18
GLU L  85
 None
 1.13A 3jx5A-4zs7L:
undetectable
3jx5B-4zs7L:
undetectable		 3jx5A-4zs7L:
19.35
3jx5B-4zs7L:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 VAL A 117
ARG A 125
VAL A 105
GLU A 116
 None
 1.27A 3jx5A-5az0A:
undetectable
3jx5B-5az0A:
undetectable		 3jx5A-5az0A:
22.87
3jx5B-5az0A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II) 		4 VAL A 363
VAL A 279
PHE A 372
GLU A 367
 None
 1.04A 3jx5A-5exeA:
undetectable
3jx5B-5exeA:
undetectable		 3jx5A-5exeA:
22.25
3jx5B-5exeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6h DH427 ANTIBODY LIGHT
CHAIN

(Macaca mulatta) 		no annotation 4 VAL L 109
ARG L  63
VAL L  18
GLU L  85
 None
 1.02A 3jx5A-5f6hL:
undetectable
3jx5B-5f6hL:
undetectable		 3jx5A-5f6hL:
21.12
3jx5B-5f6hL:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcs DIABODY

(Homo sapiens) 		PF07686
(V-set) 		4 VAL H 108
ARG H  63
VAL H  18
GLU H  85
 None
 1.22A 3jx5A-5fcsH:
undetectable
3jx5B-5fcsH:
undetectable		 3jx5A-5fcsH:
18.63
3jx5B-5fcsH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcs DIABODY

(Homo sapiens) 		PF07686
(V-set) 		4 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
SO4  L 304 ( 4.9A)
None
None
 0.96A 3jx5A-5fcsL:
undetectable
3jx5B-5fcsL:
undetectable		 3jx5A-5fcsL:
19.95
3jx5B-5fcsL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcu JR4 FAB LIGHT CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
SO4  L 303 (-3.9A)
None
SO4  L 301 ( 4.5A)
 1.11A 3jx5A-5fcuL:
undetectable
3jx5B-5fcuL:
undetectable		 3jx5A-5fcuL:
19.54
3jx5B-5fcuL:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhx CAT-2000 FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 1.08A 3jx5A-5hhxL:
undetectable
3jx5B-5hhxL:
undetectable		 3jx5A-5hhxL:
20.09
3jx5B-5hhxL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihz 1E01 FAB FRAGMENT
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B 126
ARG B  75
VAL B  19
GLU B  99
 None
 1.05A 3jx5A-5ihzB:
undetectable
3jx5B-5ihzB:
undetectable		 3jx5A-5ihzB:
19.86
3jx5B-5ihzB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 LIGHT
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 1.00A 3jx5A-5iltL:
undetectable
3jx5B-5iltL:
undetectable		 3jx5A-5iltL:
19.86
3jx5B-5iltL:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir3 IG LAMBDA CHAIN V-VI
REGION AR

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 110
ARG A  62
VAL A  18
GLU A  86
 None
 1.17A 3jx5A-5ir3A:
undetectable
3jx5B-5ir3A:
undetectable		 3jx5A-5ir3A:
14.70
3jx5B-5ir3A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j74 SCFV AM2.2

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 251
ARG A 204
VAL A 160
GLU A 226
 None
 1.03A 3jx5A-5j74A:
undetectable
3jx5B-5j74A:
undetectable		 3jx5A-5j74A:
19.71
3jx5B-5j74A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo5 10E8 GLV

(Homo sapiens) 		no annotation 4 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 1.13A 3jx5A-5jo5L:
undetectable
3jx5B-5jo5L:
undetectable		 3jx5A-5jo5L:
18.85
3jx5B-5jo5L:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 VAL A 341
TRP A 323
TRP A 347
PHE A 290
 None
 1.11A 3jx5A-5jseA:
undetectable
3jx5B-5jseA:
undetectable		 3jx5A-5jseA:
21.55
3jx5B-5jseA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6q H5AL

(Homo sapiens) 		PF07686
(V-set) 		4 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.23A 3jx5A-5l6qA:
undetectable
3jx5B-5l6qA:
undetectable		 3jx5A-5l6qA:
14.99
3jx5B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m76 LIGHT CHAIN DIMER

(Homo sapiens) 		no annotation 4 VAL A 108
ARG A  61
VAL A  18
GLU A  83
 None
 1.16A 3jx5A-5m76A:
undetectable
3jx5B-5m76A:
undetectable		 3jx5A-5m76A:
21.27
3jx5B-5m76A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3jx5A-5m8tA:
undetectable
3jx5B-5m8tA:
undetectable		 3jx5A-5m8tA:
20.21
3jx5B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mes LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 1.05A 3jx5A-5mesL:
undetectable
3jx5B-5mesL:
undetectable		 3jx5A-5mesL:
20.00
3jx5B-5mesL:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2k BRIAKINUMAB FAB
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 VAL G 110
ARG G  62
VAL G  18
GLU G  84
 None
 1.17A 3jx5A-5n2kG:
undetectable
3jx5B-5n2kG:
undetectable		 3jx5A-5n2kG:
12.07
3jx5B-5n2kG:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN

(Homo sapiens) 		no annotation 4 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.92A 3jx5A-5ocyL:
undetectable
3jx5B-5ocyL:
undetectable		 3jx5A-5ocyL:
16.84
3jx5B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4z ANTIBODY DH501 FAB
LIGHT CHAIN

(Macaca mulatta) 		no annotation 4 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 1.09A 3jx5A-5t4zL:
undetectable
3jx5B-5t4zL:
undetectable		 3jx5A-5t4zL:
19.75
3jx5B-5t4zL:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukn DH522UCA FAB
FRAGMENT LIGHT CHAIN

(Macaca mulatta) 		no annotation 4 VAL L 106
ARG L  61
VAL L  19
GLU L  83
 None
 1.02A 3jx5A-5uknL:
undetectable
3jx5B-5uknL:
undetectable		 3jx5A-5uknL:
12.25
3jx5B-5uknL:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf6 SINGLE CHAIN
VARIABLE FRAGMENT

(Gallus gallus) 		no annotation 4 VAL A 104
ARG A  58
VAL A  16
GLU A  80
 None
 1.17A 3jx5A-5vf6A:
undetectable
3jx5B-5vf6A:
undetectable		 3jx5A-5vf6A:
11.11
3jx5B-5vf6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 VAL A  57
TRP A  56
PHE A  49
GLU A  54
 None
 1.09A 3jx5A-5vyoA:
undetectable
3jx5B-5vyoA:
0.4		 3jx5A-5vyoA:
11.83
3jx5B-5vyoA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB 35O22 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 VAL I 106
ARG I  61
VAL I  19
GLU I  83
 None
 1.15A 3jx5A-5wduI:
undetectable
3jx5B-5wduI:
undetectable		 3jx5A-5wduI:
11.91
3jx5B-5wduI:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5w NECTIN-1

(Sus scrofa) 		PF07686
(V-set) 		4 VAL B 106
ARG B  60
VAL B  11
GLU B  83
 None
 1.08A 3jx5A-5x5wB:
undetectable
3jx5B-5x5wB:
undetectable		 3jx5A-5x5wB:
12.83
3jx5B-5x5wB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcv VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA

(Homo sapiens;
Rattus) 		no annotation 4 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.04A 3jx5A-5xcvB:
undetectable
3jx5B-5xcvB:
undetectable		 3jx5A-5xcvB:
16.12
3jx5B-5xcvB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS

(Homo sapiens) 		no annotation 4 ARG A 129
VAL A  65
PHE A 113
GLU A 106
 None
 1.20A 3jx5A-5xf7A:
undetectable
3jx5B-5xf7A:
undetectable		 3jx5A-5xf7A:
10.85
3jx5B-5xf7A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfg RAN GUANINE
NUCLEOTIDE RELEASE
FACTOR

(Homo sapiens) 		no annotation 4 VAL A  85
VAL A  82
PHE A  68
GLU A  61
 None
 1.28A 3jx5A-5yfgA:
undetectable
3jx5B-5yfgA:
undetectable		 3jx5A-5yfgA:
16.82
3jx5B-5yfgA:
16.82