SIMILAR PATTERNS OF AMINO ACIDS FOR 3JWQ_C_VIAC901_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 TYR A 131
LEU A 154
PHE A 126
VAL A 113
 None
 1.06A 3jwqC-1al8A:
undetectable		 3jwqC-1al8A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c20 DEAD RINGER PROTEIN

(Drosophila
melanogaster) 		PF01388
(ARID) 		4 TYR A 105
LEU A  46
GLN A   9
PHE A   6
 None
 1.16A 3jwqC-1c20A:
undetectable		 3jwqC-1c20A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 TYR B 177
HIS B 150
LEU B 191
VAL B 245
 TAR  B 900 (-4.6A)
None
None
None
 1.13A 3jwqC-1ccwB:
undetectable		 3jwqC-1ccwB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 HIS A  19
LEU A   5
GLN A 360
PHE A 362
 None
 0.95A 3jwqC-1e43A:
undetectable		 3jwqC-1e43A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivl IGG-KAPPA M29B FV
(LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 TYR A  50
LEU A   4
GLN A  90
PHE A  96
 None
 1.11A 3jwqC-1ivlA:
undetectable		 3jwqC-1ivlA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 HIS C 446
GLN A  93
PHE A 320
VAL A  97
 ZN  A   3 ( 3.4A)
None
None
None
 0.98A 3jwqC-1o7dC:
undetectable		 3jwqC-1o7dC:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		4 HIS A 243
GLN A 289
PHE A 266
VAL A 131
 None
 1.02A 3jwqC-1ovwA:
undetectable		 3jwqC-1ovwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 736
HIS A 737
LEU A 984
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.55A 3jwqC-1sojA:
37.3		 3jwqC-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		4 TYR A  64
HIS A  35
LEU A  68
VAL A 212
 None
 1.10A 3jwqC-1spjA:
undetectable		 3jwqC-1spjA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyj CELLULOSOMAL
SCAFFOLDIN

(Pseudobacteroides
cellulosolvens) 		PF00963
(Cohesin) 		4 TYR A  56
HIS A  80
LEU A 129
VAL A 111
 None
 1.10A 3jwqC-1tyjA:
undetectable		 3jwqC-1tyjA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 TYR A 324
LEU A 279
PHE A 392
VAL A 356
 None
 1.15A 3jwqC-1uypA:
undetectable		 3jwqC-1uypA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v96 HYPOTHETICAL PROTEIN
PH0500

(Pyrococcus
horikoshii) 		no annotation 4 TYR A  67
LEU A 112
PHE A 136
VAL A 140
 None
 1.13A 3jwqC-1v96A:
undetectable		 3jwqC-1v96A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 LEU A 611
GLN A 617
PHE A 616
VAL A 598
 None
 0.96A 3jwqC-1w27A:
undetectable		 3jwqC-1w27A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		4 HIS A 244
LEU A 118
PHE A 111
VAL A 107
 None
 1.15A 3jwqC-1wnbA:
undetectable		 3jwqC-1wnbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2

(Homo sapiens) 		PF03114
(BAR) 		4 TYR A 225
HIS A 226
LEU A  68
GLN A  59
 None
 0.78A 3jwqC-1x03A:
undetectable		 3jwqC-1x03A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A 175
GLN A 179
PHE A 182
VAL A 186
 None
 1.14A 3jwqC-1x0lA:
undetectable		 3jwqC-1x0lA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		4 HIS A  98
LEU A  47
PHE A  40
VAL A  36
 None
 1.04A 3jwqC-1xknA:
undetectable		 3jwqC-1xknA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 HIS A  88
LEU A  51
PHE A  38
VAL A  34
 None
 1.02A 3jwqC-1zbrA:
undetectable		 3jwqC-1zbrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 211
HIS A 212
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.64A 3jwqC-1zklA:
38.0		 3jwqC-1zklA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		4 HIS A  64
MET A 229
LEU A 138
VAL A 180
 None
 1.12A 3jwqC-2bsxA:
undetectable		 3jwqC-2bsxA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE

(Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes) 		4 TYR A 551
LEU A 562
PHE A 434
VAL A 447
 None
 1.05A 3jwqC-2bw3A:
undetectable		 3jwqC-2bw3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy3 CYTOCHROME C3

(Desulfomicrobium
norvegicum) 		PF02085
(Cytochrom_CIII) 		4 TYR A   8
GLN A  91
PHE A  88
VAL A  84
 HEM  A 119 (-4.5A)
HEM  A 120 ( 3.3A)
HEM  A 122 (-3.8A)
None
 1.12A 3jwqC-2cy3A:
undetectable		 3jwqC-2cy3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 499
GLN A 451
PHE A 452
VAL A 482
 C2O  A 602 (-3.3A)
None
None
None
 1.13A 3jwqC-2fqdA:
undetectable		 3jwqC-2fqdA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 HIS A  49
LEU A  17
PHE A 139
VAL A 143
 ZN  A 500 (-3.2A)
None
None
None
 1.07A 3jwqC-2hxvA:
undetectable		 3jwqC-2hxvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 TYR A 131
LEU A 175
GLN A 174
PHE A 200
 None
 1.04A 3jwqC-2j3hA:
undetectable		 3jwqC-2j3hA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		4 TYR A 269
LEU A 379
PHE A 407
VAL A 459
 None
 0.88A 3jwqC-2jf4A:
undetectable		 3jwqC-2jf4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2k METHIONINE SYNTHASE

(Homo sapiens) 		PF02965
(Met_synt_B12) 		4 TYR A1227
LEU A1097
PHE A1100
VAL A1102
 None
 1.08A 3jwqC-2o2kA:
undetectable		 3jwqC-2o2kA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		4 TYR A 609
HIS A 600
LEU A 280
VAL A 501
 None
 1.13A 3jwqC-2o36A:
undetectable		 3jwqC-2o36A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		4 HIS A 135
LEU A 249
PHE A 191
VAL A 187
 GLC  A 600 (-4.1A)
None
None
None
 1.10A 3jwqC-2osyA:
undetectable		 3jwqC-2osyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		4 TYR A  92
HIS A  97
LEU A 176
PHE A 206
 None
 1.15A 3jwqC-2psfA:
undetectable		 3jwqC-2psfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvb HALOALKANE
DEHALOGENASE 3

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 HIS A 108
MET A 139
PHE A 152
VAL A 148
 None
None
EDO  A   1 ( 4.9A)
None
 1.16A 3jwqC-2qvbA:
undetectable		 3jwqC-2qvbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 371
HIS A 372
MET A 569
GLN A 581
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.81A 3jwqC-2qykA:
39.2		 3jwqC-2qykA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 HIS A 241
LEU A 171
PHE A 119
VAL A 122
 CO  A4113 ( 3.4A)
None
None
None
 1.08A 3jwqC-2r5vA:
undetectable		 3jwqC-2r5vA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		6 TYR A 680
HIS A 681
LEU A 883
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.62A 3jwqC-2r8qA:
40.3		 3jwqC-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		6 TYR A 680
HIS A 681
MET A 874
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.70A 3jwqC-2r8qA:
40.3		 3jwqC-2r8qA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rck JUVENILE HORMONE
BINDING PROTEIN

(Galleria
mellonella) 		PF06585
(JHBP) 		4 LEU A  26
GLN A  73
PHE A  70
VAL A  67
 None
 1.16A 3jwqC-2rckA:
undetectable		 3jwqC-2rckA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3

(Homo sapiens) 		PF03114
(BAR) 		4 TYR A 202
HIS A 203
LEU A  45
GLN A  36
 None
 1.11A 3jwqC-2z0vA:
undetectable		 3jwqC-2z0vA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0e MANNOSE/SIALIC
ACID-BINDING LECTIN

(Polygonatum
cyrtonema) 		PF01453
(B_lectin) 		4 HIS A  58
MET A  26
LEU A  16
PHE A  11
 None
 1.09A 3jwqC-3a0eA:
undetectable		 3jwqC-3a0eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		4 TYR A  76
HIS A  81
LEU A 171
PHE A 201
 None
 1.10A 3jwqC-3a2lA:
undetectable		 3jwqC-3a2lA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 612
HIS A 613
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.46A 3jwqC-3b2rA:
44.9		 3jwqC-3b2rA:
93.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 612
HIS A 613
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.37A 3jwqC-3bjcA:
47.4		 3jwqC-3bjcA:
35.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED

(Myxococcus
xanthus) 		PF00204
(DNA_gyraseB) 		4 HIS A 223
LEU A 282
PHE A 339
VAL A 271
 None
 1.01A 3jwqC-3cwvA:
undetectable		 3jwqC-3cwvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 555
HIS A 556
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.43A 3jwqC-3ecnA:
37.9		 3jwqC-3ecnA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 325
HIS A 326
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.58A 3jwqC-3g4gA:
38.8		 3jwqC-3g4gA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 TYR A 655
HIS A 656
GLN A 859
PHE A 862
 None
 0.33A 3jwqC-3ibjA:
38.4		 3jwqC-3ibjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Toxoplasma
gondii) 		PF01048
(PNP_UDP_1) 		4 HIS A  69
MET A 235
LEU A 143
VAL A 184
 None
 1.09A 3jwqC-3mb8A:
undetectable		 3jwqC-3mb8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 HIS A 232
LEU A 104
PHE A  60
VAL A  89
 ZN  A 454 (-3.3A)
None
None
None
 0.92A 3jwqC-3mduA:
undetectable		 3jwqC-3mduA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 TYR A   5
LEU A 106
PHE A  43
VAL A  45
 None
 1.16A 3jwqC-3mx9A:
undetectable		 3jwqC-3mx9A:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 HIS A 252
GLN A 453
PHE A 456
VAL A 460
 None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
None
 0.57A 3jwqC-3n3zA:
41.8		 3jwqC-3n3zA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 HIS A 256
GLN A 453
PHE A 456
VAL A 460
 ZN  A 507 (-3.8A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
None
 0.83A 3jwqC-3n3zA:
41.8		 3jwqC-3n3zA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 HIS A 488
LEU A 151
GLN A 160
VAL A 526
 None
 1.03A 3jwqC-3n92A:
undetectable		 3jwqC-3n92A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkh INTEGRASE

(Staphylococcus
aureus) 		PF00589
(Phage_integrase) 		4 MET A  45
LEU A 165
PHE A 130
VAL A 129
 None
 1.15A 3jwqC-3nkhA:
undetectable		 3jwqC-3nkhA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 233
HIS A 234
GLN A 443
PHE A 446
 None
None
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 0.53A 3jwqC-3o57A:
39.1		 3jwqC-3o57A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqc UFM1-SPECIFIC
PROTEASE 2

(Mus musculus) 		PF07910
(Peptidase_C78) 		4 TYR A 282
HIS A 420
GLN A 300
VAL A 348
 None
 1.07A 3jwqC-3oqcA:
undetectable		 3jwqC-3oqcA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 TYR A 226
LEU A 344
GLN A 329
VAL A 339
 None
 1.08A 3jwqC-3rg2A:
undetectable		 3jwqC-3rg2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.91A 3jwqC-3sl5A:
39.2		 3jwqC-3sl5A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1t DMMA HALOALKANE
DEHALOGENASE

(unidentified) 		PF00561
(Abhydrolase_1) 		4 TYR A 117
HIS A 122
LEU A 205
PHE A 236
 None
 1.14A 3jwqC-3u1tA:
undetectable		 3jwqC-3u1tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u66 PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF09850
(DotU) 		4 TYR A  14
GLN A 133
PHE A 162
VAL A 159
 None
 1.04A 3jwqC-3u66A:
undetectable		 3jwqC-3u66A:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 524
HIS A 525
MET A 713
GLN A 726
PHE A 729
VAL A 733
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
None
 0.57A 3jwqC-3ui7A:
44.0		 3jwqC-3ui7A:
42.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 MET A 235
LEU A 224
PHE A 358
VAL A 376
 None
 1.06A 3jwqC-3ut3A:
undetectable		 3jwqC-3ut3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		4 TYR A 367
HIS A 368
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.48A 3jwqC-3v94A:
37.0		 3jwqC-3v94A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv4 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		4 HIS A 156
LEU A   6
PHE A  16
VAL A  46
 None
 1.13A 3jwqC-3vv4A:
undetectable		 3jwqC-3vv4A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 MET A 263
LEU A  91
GLN A  95
VAL A 102
 None
 1.07A 3jwqC-3wd8A:
undetectable		 3jwqC-3wd8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 4 TYR B 219
MET B 302
LEU B 408
VAL B 392
 None
 1.11A 3jwqC-3x17B:
undetectable		 3jwqC-3x17B:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 TYR A 802
LEU A 767
PHE A 742
VAL A 737
 None
 1.09A 3jwqC-4a0hA:
undetectable		 3jwqC-4a0hA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 TYR A 109
HIS A 100
MET A 118
VAL A 205
 None
 1.07A 3jwqC-4ccdA:
undetectable		 3jwqC-4ccdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 TYR A 326
HIS A 347
LEU A 101
VAL A 201
 None
 1.13A 3jwqC-4cgnA:
undetectable		 3jwqC-4cgnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eoz SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 TYR A 259
LEU A 282
PHE A 251
VAL A 206
 None
 1.16A 3jwqC-4eozA:
undetectable		 3jwqC-4eozA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 655
HIS A 656
MET A 847
GLN A 859
PHE A 862
 None
 0.42A 3jwqC-4htzA:
44.2		 3jwqC-4htzA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		6 TYR A 668
HIS A 669
LEU A 870
GLN A 874
PHE A 877
VAL A 881
 None
 0.66A 3jwqC-4i15A:
39.3		 3jwqC-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		5 TYR A 668
HIS A 669
MET A 861
PHE A 877
VAL A 881
 None
 0.63A 3jwqC-4i15A:
39.3		 3jwqC-4i15A:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8z SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 TYR A 259
LEU A 282
PHE A 251
VAL A 206
 None
 1.16A 3jwqC-4j8zA:
undetectable		 3jwqC-4j8zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		4 TYR A 382
MET A 299
LEU A 315
PHE A 323
 None
 1.05A 3jwqC-4lz6A:
undetectable		 3jwqC-4lz6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 4 TYR B 238
LEU B 327
PHE B 228
VAL B   7
 None
None
None
FDA  B 402 (-4.8A)
 1.07A 3jwqC-4mo2B:
undetectable		 3jwqC-4mo2B:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		4 MET A 231
LEU A 220
PHE A 359
VAL A 376
 None
 1.16A 3jwqC-4p0fA:
undetectable		 3jwqC-4p0fA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 MAOC FAMILY PROTEIN
UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2

(Mycolicibacterium
smegmatis) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 HIS A  28
GLN A 136
PHE A  93
VAL B  80
 None
 1.15A 3jwqC-4rv2A:
undetectable		 3jwqC-4rv2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 405
HIS A 406
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
 0.41A 3jwqC-4wziA:
38.9		 3jwqC-4wziA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020

(Homo sapiens) 		PF08144
(CPL) 		4 MET A 309
GLN A 281
PHE A 280
VAL A 294
 None
 1.14A 3jwqC-4wzwA:
undetectable		 3jwqC-4wzwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 HIS A 408
LEU A 563
GLN A 566
VAL A 518
 None
 1.11A 3jwqC-4xwhA:
undetectable		 3jwqC-4xwhA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 TYR A 327
LEU A 252
PHE A 213
VAL A 456
 None
 1.16A 3jwqC-4y67A:
undetectable		 3jwqC-4y67A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af7 ACYL-COA
DEHYDROGENASE

(Advenella
mimigardefordensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 255
GLN A 259
PHE A 262
VAL A 266
 None
 1.12A 3jwqC-5af7A:
undetectable		 3jwqC-5af7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 222
HIS A 223
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.57A 3jwqC-5b25A:
37.7		 3jwqC-5b25A:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 109
LEU A  92
GLN A  67
VAL A 443
 None
 1.16A 3jwqC-5cx8A:
undetectable		 3jwqC-5cx8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec1 ANTIBODY FAB
FRAGMENT LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  50
LEU B   4
GLN B  90
PHE B  96
 None
 1.03A 3jwqC-5ec1B:
undetectable		 3jwqC-5ec1B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 TYR A 161
HIS A  35
LEU A  29
GLN A  27
 None
 1.15A 3jwqC-5fsrA:
undetectable		 3jwqC-5fsrA:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 6 TYR A 668
HIS A 669
LEU A 871
GLN A 875
PHE A 878
VAL A 882
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.9A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
None
 0.52A 3jwqC-5h2rA:
40.3		 3jwqC-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 6 TYR A 668
HIS A 669
MET A 862
GLN A 875
PHE A 878
VAL A 882
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
None
 0.66A 3jwqC-5h2rA:
40.3		 3jwqC-5h2rA:
34.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxz BARBITURASE

(Rhodococcus
erythropolis) 		PF09663
(Amido_AtzD_TrzD) 		4 HIS A  93
LEU A  30
PHE A  97
VAL A 243
 None
 0.95A 3jwqC-5hxzA:
undetectable		 3jwqC-5hxzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 4 TYR A 487
LEU A 321
PHE A 328
VAL A 411
 None
 1.07A 3jwqC-5id6A:
undetectable		 3jwqC-5id6A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l20 CLOSTRIPAIN-RELATED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03415
(Peptidase_C11)
no annotation 		4 TYR A  44
MET B 209
LEU B 218
VAL A 148
 None
 0.96A 3jwqC-5l20A:
undetectable		 3jwqC-5l20A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 MET B 579
LEU B 576
PHE B 623
VAL B 539
 None
 0.95A 3jwqC-5l9wB:
undetectable		 3jwqC-5l9wB:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nji PHTHIOCEROL/PHENOLPH
THIOCEROL SYNTHESIS
POLYKETIDE SYNTHASE
TYPE I PPSC

(Mycobacterium
tuberculosis) 		PF14765
(PS-DH) 		4 HIS A1086
MET A1214
LEU A 999
VAL A1196
 8Z2  A1301 ( 4.7A)
8Z2  A1301 ( 3.1A)
8Z2  A1301 (-3.8A)
None
 0.98A 3jwqC-5njiA:
undetectable		 3jwqC-5njiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 TYR A 405
HIS A 406
MET A 603
GLN A 615
PHE A 618
 None
None
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
 0.62A 3jwqC-5ohjA:
39.1		 3jwqC-5ohjA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		4 TYR E 335
HIS E 360
PHE E 507
VAL E 511
 None
 1.09A 3jwqC-5u8sE:
undetectable		 3jwqC-5u8sE:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 4 HIS A  83
LEU A 284
PHE A 291
VAL A 295
 None
 0.43A 3jwqC-5vydA:
40.1		 3jwqC-5vydA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 4 HIS A  87
LEU A 284
PHE A 291
VAL A 295
 ZN  A 401 (-3.4A)
None
None
None
 0.84A 3jwqC-5vydA:
40.1		 3jwqC-5vydA:
32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 5 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 (-3.4A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
 0.76A 3jwqC-5wh6A:
39.4		 3jwqC-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN

(Felis catus) 		no annotation 4 MET A 175
LEU A 173
PHE A  34
VAL A  35
 None
 1.14A 3jwqC-5xmmA:
undetectable		 3jwqC-5xmmA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S7E

(Leishmania
donovani) 		no annotation 4 HIS I 181
GLN I  99
PHE I  65
VAL I  63
 G  1 758 ( 4.0A)
U  1 759 ( 3.5A)
G  1 760 ( 4.5A)
None
 1.14A 3jwqC-6az1I:
undetectable		 3jwqC-6az1I:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bms PALMITOYLTRANSFERASE

(Danio rerio) 		no annotation 4 TYR A  59
LEU A 214
PHE A 207
VAL A 203
 None
LMT  A1003 (-4.4A)
PLM  A1006 (-4.1A)
PLM  A1006 (-4.7A)
 1.14A 3jwqC-6bmsA:
undetectable		 3jwqC-6bmsA:
12.42