SIMILAR PATTERNS OF AMINO ACIDS FOR 3JWQ_A_VIAA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 TYR A 168
LEU A 187
MET A   1
PHE A  81
VAL A 120
 None
 1.48A 3jwqA-1muuA:
undetectable		 3jwqA-1muuA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 736
HIS A 737
LEU A 895
LEU A 984
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.52A 3jwqA-1sojA:
37.4		 3jwqA-1sojA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 OUTER CAPSID PROTEIN
P8

(Rice dwarf
virus) 		no annotation 5 LEU P 273
VAL P 291
LEU P 282
PHE P 252
VAL P 254
 None
 1.27A 3jwqA-1uf2P:
undetectable		 3jwqA-1uf2P:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 TYR A 692
HIS A 689
LEU A 671
LEU A 632
PHE A 639
 None
 1.24A 3jwqA-1z8lA:
2.7		 3jwqA-1z8lA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
VAL A 380
GLN A 413
PHE A 416
VAL A 421
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
None
 1.33A 3jwqA-1zklA:
38.1		 3jwqA-1zklA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		5 LEU A 160
VAL A 101
LEU A 460
PHE A 410
VAL A 406
 None
 1.43A 3jwqA-2braA:
undetectable		 3jwqA-2braA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 HIS A  49
VAL A  26
LEU A 135
PHE A 139
VAL A 143
 ZN  A 500 (-3.2A)
None
None
None
None
 1.26A 3jwqA-2hxvA:
undetectable		 3jwqA-2hxvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		5 LEU A 175
VAL A 201
LEU A 212
PHE A 311
VAL A 344
 None
 0.91A 3jwqA-2ie8A:
undetectable		 3jwqA-2ie8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzt PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF02847
(MA3) 		5 LEU A 223
VAL A 261
LEU A 295
PHE A 240
VAL A 236
 None
 1.49A 3jwqA-2kztA:
undetectable		 3jwqA-2kztA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 371
HIS A 372
MET A 569
GLN A 581
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.90A 3jwqA-2qykA:
39.2		 3jwqA-2qykA:
29.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		7 TYR A 680
HIS A 681
VAL A 853
LEU A 883
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.66A 3jwqA-2r8qA:
40.5		 3jwqA-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		7 TYR A 680
HIS A 681
VAL A 853
MET A 874
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.67A 3jwqA-2r8qA:
40.5		 3jwqA-2r8qA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xst LIPOCALIN 15

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A 139
LEU A 104
VAL A  39
PHE A  77
VAL A  86
 None
None
EDO  A1174 ( 4.7A)
EDO  A1174 (-4.6A)
None
 1.45A 3jwqA-2xstA:
undetectable		 3jwqA-2xstA:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 612
HIS A 613
LEU A 725
VAL A 782
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.42A 3jwqA-3b2rA:
45.0		 3jwqA-3b2rA:
93.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 612
HIS A 613
LEU A 725
VAL A 782
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.38A 3jwqA-3bjcA:
47.8		 3jwqA-3bjcA:
35.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		5 LEU A 225
MET A 111
GLN A 107
PHE A 104
VAL A 236
 None
 1.48A 3jwqA-3f7wA:
undetectable		 3jwqA-3f7wA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 TYR A 655
HIS A 656
LEU A 770
GLN A 859
PHE A 862
 None
 0.67A 3jwqA-3ibjA:
38.5		 3jwqA-3ibjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 HIS A1714
LEU A1723
VAL A1789
PHE A1756
VAL A1727
 None
 1.47A 3jwqA-3ig3A:
undetectable		 3jwqA-3ig3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 TYR A1793
HIS A1714
VAL A1789
PHE A1756
VAL A1727
 None
 1.31A 3jwqA-3ig3A:
undetectable		 3jwqA-3ig3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 129
LEU A 235
LEU A 106
PHE A 166
VAL A 170
 None
 1.41A 3jwqA-3jxfA:
undetectable		 3jwqA-3jxfA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc3 DSRE/DSRF-LIKE
FAMILY PROTEIN

(Sulfolobus
solfataricus) 		PF02635
(DrsE) 		5 LEU A  35
VAL A 109
LEU A 114
PHE A  52
VAL A  21
 None
MLY  A  62 ( 4.2A)
None
None
None
 1.22A 3jwqA-3mc3A:
undetectable		 3jwqA-3mc3A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU B 103
VAL B 111
LEU B  62
PHE B  56
VAL B  54
 None
 1.49A 3jwqA-3mm5B:
undetectable		 3jwqA-3mm5B:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o44 HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		5 TYR A 666
LEU A 662
VAL A 642
PHE A 713
VAL A 711
 None
 1.24A 3jwqA-3o44A:
undetectable		 3jwqA-3o44A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13201
(PCMD) 		5 TYR A 277
LEU A 233
VAL A 350
LEU A 197
VAL A 359
 None
 1.50A 3jwqA-3s30A:
undetectable		 3jwqA-3s30A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.01A 3jwqA-3sl5A:
39.2		 3jwqA-3sl5A:
28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 524
HIS A 525
LEU A 635
MET A 713
GLN A 726
PHE A 729
VAL A 733
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
None
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
None
 0.60A 3jwqA-3ui7A:
44.3		 3jwqA-3ui7A:
42.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2x EXODEOXYRIBONUCLEASE

(Methanothermobacter
thermautotrophicus) 		PF03372
(Exo_endo_phos) 		5 TYR A  56
LEU A  36
VAL A  53
PHE A  22
VAL A  17
 None
 1.47A 3jwqA-3w2xA:
undetectable		 3jwqA-3w2xA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 TYR A 326
HIS A 347
LEU A 418
LEU A 101
VAL A 201
 None
 1.29A 3jwqA-4cgnA:
undetectable		 3jwqA-4cgnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 276
VAL A 332
GLN A 328
PHE A 325
VAL A 301
 None
 1.10A 3jwqA-4d5gA:
undetectable		 3jwqA-4d5gA:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 655
HIS A 656
LEU A 770
MET A 847
GLN A 859
PHE A 862
 None
 0.39A 3jwqA-4htzA:
44.3		 3jwqA-4htzA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		7 TYR A 668
HIS A 669
VAL A 840
LEU A 870
GLN A 874
PHE A 877
VAL A 881
 None
 0.69A 3jwqA-4i15A:
39.4		 3jwqA-4i15A:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		6 TYR A 668
HIS A 669
VAL A 840
MET A 861
PHE A 877
VAL A 881
 None
 0.65A 3jwqA-4i15A:
39.4		 3jwqA-4i15A:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION

(Danio rerio) 		PF08337
(Plexin_cytopl) 		5 TYR A1071
HIS A 991
VAL A1067
PHE A1034
VAL A1004
 None
 1.20A 3jwqA-4m8nA:
undetectable		 3jwqA-4m8nA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 798
VAL A 827
LEU A 841
PHE A 937
VAL A 857
 None
 1.25A 3jwqA-4n1aA:
undetectable		 3jwqA-4n1aA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 798
VAL A 827
LEU A 841
PHE A 937
VAL A 857
 None
 1.26A 3jwqA-4nh0A:
undetectable		 3jwqA-4nh0A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 LEU A 333
VAL A 127
LEU A  46
PHE A  52
VAL A  56
 None
 1.43A 3jwqA-4q3rA:
undetectable		 3jwqA-4q3rA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		5 TYR A 572
LEU A 367
VAL A 548
PHE A 344
VAL A 384
 None
 1.05A 3jwqA-4qlbA:
undetectable		 3jwqA-4qlbA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qu7 G-RICH SEQUENCE
FACTOR 1

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU A 408
VAL A 403
LEU A 424
PHE A 420
VAL A 464
 None
 1.24A 3jwqA-4qu7A:
undetectable		 3jwqA-4qu7A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 TYR A1664
LEU A1613
GLN A1544
PHE A1547
VAL A1551
 None
 1.48A 3jwqA-4rh7A:
undetectable		 3jwqA-4rh7A:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		5 LEU A 160
VAL A 101
LEU A 460
PHE A 410
VAL A 406
 None
 1.33A 3jwqA-4txkA:
undetectable		 3jwqA-4txkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE

(Streptomyces
hygroscopicus) 		no annotation 5 TYR A 184
LEU A 322
VAL A  34
PHE A  64
VAL A 320
 None
 1.46A 3jwqA-5a3kA:
undetectable		 3jwqA-5a3kA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eh1 INTERFERON GAMMA
RECEPTOR 2

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		5 TYR A  69
VAL A 111
LEU A  40
GLN A  45
VAL A  84
 None
None
None
None
GOL  A 306 (-4.2A)
 1.20A 3jwqA-5eh1A:
undetectable		 3jwqA-5eh1A:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 7 TYR A 668
HIS A 669
VAL A 841
LEU A 871
GLN A 875
PHE A 878
VAL A 882
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-4.9A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
None
 0.59A 3jwqA-5h2rA:
40.4		 3jwqA-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 6 TYR A 668
HIS A 669
VAL A 841
MET A 862
PHE A 878
VAL A 882
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.8A)
None
 0.52A 3jwqA-5h2rA:
40.4		 3jwqA-5h2rA:
34.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kak UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF07978
(NIPSNAP) 		5 LEU A   9
VAL A  79
LEU A  69
GLN A  29
VAL A  50
 None
None
None
EDO  A 201 (-3.8A)
None
 1.36A 3jwqA-5kakA:
undetectable		 3jwqA-5kakA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 TYR A 405
HIS A 406
MET A 603
GLN A 615
PHE A 618
 None
None
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
 0.63A 3jwqA-5ohjA:
39.2		 3jwqA-5ohjA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 5 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 (-3.4A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
 0.85A 3jwqA-5wh6A:
39.5		 3jwqA-5wh6A:
undetectable