SIMILAR PATTERNS OF AMINO ACIDS FOR 3JW3_B_TOPB208_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czf | POLYGALACTURONASE II (Aspergillusniger) |
PF00295(Glyco_hydro_28) | 5 | ALA A 38LEU A 61VAL A 72ILE A 107LEU A 142 | None | 1.19A | 3jw3B-1czfA:undetectable | 3jw3B-1czfA:17.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dr6 | DIHYDROFOLATEREDUCTASE (Gallus gallus) |
PF00186(DHFR_1) | 5 | ALA A 9GLU A 30ILE A 60LEU A 67TYR A 121 | HBI A 198 ( 3.6A)HBI A 198 (-3.0A)NoneNoneNone | 1.17A | 3jw3B-1dr6A:21.4 | 3jw3B-1dr6A:31.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dr6 | DIHYDROFOLATEREDUCTASE (Gallus gallus) |
PF00186(DHFR_1) | 5 | ALA A 9LEU A 22GLU A 30LEU A 67TYR A 121 | HBI A 198 ( 3.6A)NAP A 191 ( 4.7A)HBI A 198 (-3.0A)NoneNone | 0.76A | 3jw3B-1dr6A:21.4 | 3jw3B-1dr6A:31.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fzt | PHOSPHOGLYCERATEMUTASE (Schizosaccharomycespombe) |
PF00300(His_Phos_1) | 5 | ALA A 169LEU A 141ILE A 148ILE A 160TYR A 195 | None | 1.31A | 3jw3B-1fztA:undetectable | 3jw3B-1fztA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ia5 | POLYGALACTURONASE (Aspergillusaculeatus) |
PF00295(Glyco_hydro_28) | 5 | ALA A 15LEU A 38VAL A 49ILE A 84LEU A 120 | None | 1.19A | 3jw3B-1ia5A:undetectable | 3jw3B-1ia5A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2z | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Helicobacterpylori) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ALA A 256VAL A 159ILE A 149LEU A 137ILE A 161 | None | 1.26A | 3jw3B-1j2zA:undetectable | 3jw3B-1j2zA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6o | TATD-RELATEDDEOXYRIBONUCLEASE (Thermotogamaritima) |
PF01026(TatD_DNase) | 5 | LEU A 184VAL A 191ILE A 227LEU A 231ILE A 196 | None | 1.24A | 3jw3B-1j6oA:undetectable | 3jw3B-1j6oA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsx | GLUCOSE-INHIBITEDDIVISION PROTEIN B (Escherichiacoli) |
PF02527(GidB) | 5 | ALA A 90GLU A 89ILE A 58LEU A 16ILE A 85 | None | 1.07A | 3jw3B-1jsxA:4.0 | 3jw3B-1jsxA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofu | HYPOTHETICAL PROTEINPA3008 (Pseudomonasaeruginosa) |
PF03846(SulA) | 5 | ALA X 95LEU X 87ILE X 158LEU X 156ILE X 65 | None | 1.29A | 3jw3B-1ofuX:undetectable | 3jw3B-1ofuX:18.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u70 | DIHYDROFOLATEREDUCTASE (Mus musculus) |
PF00186(DHFR_1) | 5 | ALA A 9GLU A 30ILE A 60LEU A 67TYR A 121 | NDP A 188 (-3.6A)MTX A 187 (-3.0A)MTX A 187 ( 4.2A)MTX A 187 ( 4.5A)None | 1.05A | 3jw3B-1u70A:20.9 | 3jw3B-1u70A:32.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u71 | DIHYDROFOLATEREDUCTASE (Homo sapiens) |
PF00186(DHFR_1) | 5 | ALA A 9GLU A 30ILE A 60LEU A 67TYR A 121 | MXA A 187 (-3.6A)MXA A 187 (-2.9A)MXA A 187 ( 4.7A)NoneNone | 1.06A | 3jw3B-1u71A:21.5 | 3jw3B-1u71A:32.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xbt | THYMIDINE KINASE,CYTOSOLIC (Homo sapiens) |
PF00265(TK) | 5 | ALA A 88VAL A 119ILE A 105LEU A 139ILE A 96 | None | 1.11A | 3jw3B-1xbtA:2.2 | 3jw3B-1xbtA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdp | POLYPHOSPHATE KINASE (Escherichiacoli) |
PF02503(PP_kinase)PF13089(PP_kinase_N)PF13090(PP_kinase_C) | 5 | ALA A 360VAL A 396ILE A 383LEU A 418ILE A 371 | None | 1.28A | 3jw3B-1xdpA:undetectable | 3jw3B-1xdpA:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a2a | DEATH-ASSOCIATEDPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 269LEU A 255VAL A 127ILE A 206ILE A 123 | None | 1.13A | 3jw3B-2a2aA:undetectable | 3jw3B-2a2aA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ag1 | BENZALDEHYDE LYASE (Pseudomonasfluorescens) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 145VAL A 132ILE A 33LEU A 166ILE A 138 | None | 1.28A | 3jw3B-2ag1A:undetectable | 3jw3B-2ag1A:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b8e | CATION-TRANSPORTINGATPASE (Archaeoglobusfulgidus) |
PF00702(Hydrolase) | 5 | ALA A 557VAL A 421ILE A 648LEU A 631ILE A 662 | None | 1.12A | 3jw3B-2b8eA:undetectable | 3jw3B-2b8eA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2blb | DIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumvivax) |
PF00186(DHFR_1) | 6 | ALA A 15LEU A 45ILE A 121LEU A 128ILE A 173TYR A 179 | CP7 A1240 (-3.7A)NDP A1239 (-4.8A)MES A1241 ( 4.1A)MES A1241 (-4.5A)CP7 A1240 ( 3.8A)None | 1.04A | 3jw3B-2blbA:20.9 | 3jw3B-2blbA:25.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dvu | THERMOPHILICREVERSIBLEGAMMA-RESORCYLATEDECARBOXYLASE (Rhizobium sp.MTP-10005) |
PF04909(Amidohydro_2) | 5 | ALA A 99VAL A 123ILE A 215LEU A 321ILE A 56 | None | 1.19A | 3jw3B-2dvuA:undetectable | 3jw3B-2dvuA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hjg | GTP-BINDING PROTEINENGA (Bacillussubtilis) |
PF01926(MMR_HSR1)PF14714(KH_dom-like) | 5 | ALA A 158VAL A 85ILE A 23LEU A 55ILE A 87 | None | 1.19A | 3jw3B-2hjgA:undetectable | 3jw3B-2hjgA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iq7 | ENDOPOLYGALACTURONASE (Colletotrichumlupini) |
PF00295(Glyco_hydro_28) | 5 | ALA A 34LEU A 57VAL A 68ILE A 103LEU A 139 | None | 1.21A | 3jw3B-2iq7A:undetectable | 3jw3B-2iq7A:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j8x | URACIL-DNAGLYCOSYLASE (Humangammaherpesvirus4) |
PF03167(UDG) | 5 | ALA A 239VAL A 145ILE A 118LEU A 137ILE A 87 | None | 1.18A | 3jw3B-2j8xA:undetectable | 3jw3B-2j8xA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l4o | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcuspneumoniae) |
PF16555(GramPos_pilinD1) | 5 | ALA A 163LEU A 43GLU A 143ILE A 52LEU A 56 | None | 1.32A | 3jw3B-2l4oA:undetectable | 3jw3B-2l4oA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odp | COMPLEMENT C2 (Homo sapiens) |
PF00089(Trypsin)PF00092(VWA) | 5 | ALA A 257VAL A 273ILE A 225LEU A 233ILE A 264 | None | 0.99A | 3jw3B-2odpA:undetectable | 3jw3B-2odpA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 11LEU A 25ILE A 62LEU A 67TYR A 119 | MTX A 605 ( 3.6A)MTX A 605 ( 4.6A)MTX A 605 ( 4.6A)MTX A 605 ( 4.4A)None | 0.81A | 3jw3B-2oipA:21.8 | 3jw3B-2oipA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa4 | UTP-GLUCOSE-1-PHOSPHATEURIDYLYLTRANSFERASE (Corynebacteriumglutamicum) |
PF00483(NTP_transferase) | 5 | ALA A 121LEU A 228VAL A 138ILE A 245LEU A 166 | UPG A 326 (-3.5A)NoneNoneNoneNone | 1.25A | 3jw3B-2pa4A:undetectable | 3jw3B-2pa4A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2put | ISOMERASE DOMAIN OFGLUTAMINE-FRUCTOSE-6-PHOSPHATETRANSAMINASE(ISOMERIZING) (Candidaalbicans) |
PF01380(SIS) | 5 | ALA A 412LEU A 678ILE A 535LEU A 519ILE A 416 | None | 1.22A | 3jw3B-2putA:undetectable | 3jw3B-2putA:16.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qk8 | DIHYDROFOLATEREDUCTASE (Bacillusanthracis) |
PF00186(DHFR_1) | 8 | MET A 6ALA A 8LEU A 21GLU A 28VAL A 32ILE A 51LEU A 55TYR A 102 | MTX A 200 ( 4.1A)MTX A 200 ( 3.4A)MTX A 200 ( 4.5A)MTX A 200 ( 2.8A)MTX A 200 ( 4.7A)MTX A 200 ( 4.2A)MTX A 200 ( 4.1A)None | 0.76A | 3jw3B-2qk8A:28.4 | 3jw3B-2qk8A:98.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2voy | CATION-TRANSPORTINGATPASE (Archaeoglobusfulgidus) |
PF00702(Hydrolase) | 5 | ALA I 557VAL I 421ILE I 648LEU I 631ILE I 662 | None | 1.12A | 3jw3B-2voyI:undetectable | 3jw3B-2voyI:21.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w9s | DIHYDROFOLATEREDUCTASE TYPE 1FROM TN4003 (Staphylococcusaureus) |
PF00186(DHFR_1) | 5 | ALA A 7LEU A 20ILE A 50LEU A 54TYR A 98 | TOP A1160 ( 3.6A)TOP A1160 ( 4.2A)TOP A1160 (-4.4A)NoneNone | 0.66A | 3jw3B-2w9sA:26.2 | 3jw3B-2w9sA:43.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wlc | POLYSIALIC ACIDO-ACETYLTRANSFERASE (Neisseriameningitidis) |
PF00132(Hexapep) | 5 | LEU A 80VAL A 65ILE A 50ILE A 67TYR A 113 | None | 1.30A | 3jw3B-2wlcA:undetectable | 3jw3B-2wlcA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yab | DEATH-ASSOCIATEDPROTEIN KINASE 2 (Mus musculus) |
PF00069(Pkinase) | 5 | ALA A 269LEU A 255VAL A 127ILE A 206ILE A 123 | None | 1.10A | 3jw3B-2yabA:undetectable | 3jw3B-2yabA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3al0 | ASPARTYL/GLUTAMYL-TRNA(ASN/GLN)AMIDOTRANSFERASESUBUNIT B (Thermotogamaritima) |
PF02637(GatB_Yqey)PF02934(GatB_N) | 5 | ALA B 66LEU B 106VAL B 181ILE B 11LEU B 196 | None | 1.14A | 3jw3B-3al0B:undetectable | 3jw3B-3al0B:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 5 | ALA A 16LEU A 46ILE A 112LEU A 119TYR A 170 | RJ6 A 609 (-3.7A)RJ6 A 609 (-3.8A)RJ6 A 609 (-4.8A)RJ6 A 609 (-4.4A)NDP A 610 ( 4.9A) | 1.19A | 3jw3B-3dg8A:20.9 | 3jw3B-3dg8A:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd2 | SITE-SPECIFIC DNAENDONUCLEASE I-MSOI (Monomastix sp.OKE-1) |
PF00961(LAGLIDADG_1) | 5 | ALA A 108LEU A 101ILE A 15LEU A 7ILE A 93 | None | 1.15A | 3jw3B-3fd2A:undetectable | 3jw3B-3fd2A:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd2 | SITE-SPECIFIC DNAENDONUCLEASE I-MSOI (Monomastix sp.OKE-1) |
PF00961(LAGLIDADG_1) | 5 | ALA A 311LEU A 304ILE A 218LEU A 210ILE A 296 | None | 1.21A | 3jw3B-3fd2A:undetectable | 3jw3B-3fd2A:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g79 | NDP-N-ACETYL-D-GALACTOSAMINURONIC ACIDDEHYDROGENASE (Methanosarcinamazei) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | ALA A 228LEU A 176GLU A 155ILE A 130ILE A 149 | None | 1.32A | 3jw3B-3g79A:undetectable | 3jw3B-3g79A:14.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqm | CELL INHIBITINGFACTOR (CIFBP) (Burkholderiapseudomallei) |
PF16374(CIF) | 5 | ALA A 94VAL A 138ILE A 218LEU A 198ILE A 149 | None | 1.25A | 3jw3B-3gqmA:undetectable | 3jw3B-3gqmA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gtm | TRANSCRIPTIONELONGATION FACTORS-II (Saccharomycescerevisiae) |
PF01096(TFIIS_C)PF07500(TFIIS_M) | 5 | ALA S 237LEU S 228VAL S 206ILE S 178LEU S 156 | None | 1.03A | 3jw3B-3gtmS:undetectable | 3jw3B-3gtmS:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gx8 | MONOTHIOLGLUTAREDOXIN-5,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00462(Glutaredoxin) | 5 | ALA A 136LEU A 132VAL A 75ILE A 120LEU A 69 | None | 1.33A | 3jw3B-3gx8A:undetectable | 3jw3B-3gx8A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2z | MANNITOL-1-PHOSPHATE5-DEHYDROGENASE (Shigellaflexneri) |
PF01232(Mannitol_dh)PF08125(Mannitol_dh_C) | 5 | ALA A 251GLU A 254ILE A 308LEU A 364ILE A 328 | None | 1.07A | 3jw3B-3h2zA:undetectable | 3jw3B-3h2zA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hyv | SULFIDE-QUINONEREDUCTASE (Aquifexaeolicus) |
PF07992(Pyr_redox_2) | 5 | MET A 249ALA A 150ILE A 215LEU A 165ILE A 148 | None | 1.25A | 3jw3B-3hyvA:undetectable | 3jw3B-3hyvA:17.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i8a | DIHYDROFOLATEREDUCTASE (Staphylococcusaureus) |
PF00186(DHFR_1) | 5 | ALA X 7LEU X 20ILE X 50LEU X 54TYR X 98 | N22 X 219 ( 3.6A)N22 X 219 ( 4.6A)N22 X 219 (-4.6A)NoneNone | 0.59A | 3jw3B-3i8aX:26.2 | 3jw3B-3i8aX:44.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i8a | DIHYDROFOLATEREDUCTASE (Staphylococcusaureus) |
PF00186(DHFR_1) | 5 | ALA X 7LEU X 20VAL X 31ILE X 50TYR X 98 | N22 X 219 ( 3.6A)N22 X 219 ( 4.6A)NoneN22 X 219 (-4.6A)None | 0.42A | 3jw3B-3i8aX:26.2 | 3jw3B-3i8aX:44.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ia4 | DIHYDROFOLATEREDUCTASE (Moritellaprofunda) |
PF00186(DHFR_1) | 6 | ALA A 8GLU A 28ILE A 51LEU A 55ILE A 96TYR A 102 | MTX A 164 ( 3.7A)MTX A 164 (-2.9A)MTX A 164 (-4.1A)MTX A 164 ( 4.4A)MTX A 164 ( 4.2A)None | 0.52A | 3jw3B-3ia4A:26.5 | 3jw3B-3ia4A:45.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibs | CONSERVEDHYPOTHETICAL PROTEINBATB (Bacteroidesthetaiotaomicron) |
PF00092(VWA) | 5 | MET A 49LEU A 42ILE A 199LEU A 34ILE A 10 | NoneNoneNone CL A 216 ( 4.3A)None | 1.27A | 3jw3B-3ibsA:2.1 | 3jw3B-3ibsA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3imm | PUTATIVE SECRETEDGLYCOSYLHYDROLASE (Parabacteroidesdistasonis) |
PF06439(DUF1080) | 5 | ALA A 131VAL A 157ILE A 105LEU A 74ILE A 103 | None | 1.29A | 3jw3B-3immA:undetectable | 3jw3B-3immA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j09 | COPPER-EXPORTINGP-TYPE ATPASE A (Archaeoglobusfulgidus) |
PF00122(E1-E2_ATPase)PF00403(HMA)PF00702(Hydrolase) | 5 | ALA A 557VAL A 421ILE A 648LEU A 631ILE A 662 | None | 1.07A | 3jw3B-3j09A:2.6 | 3jw3B-3j09A:12.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mip | MSO-8G (syntheticconstruct) |
PF00961(LAGLIDADG_1) | 5 | ALA A 108LEU A 101ILE A 15LEU A 7ILE A 93 | None | 1.15A | 3jw3B-3mipA:undetectable | 3jw3B-3mipA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ojl | CAP5O (Staphylococcusaureus) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | LEU A 162GLU A 117VAL A 5ILE A 17LEU A 64 | None | 1.19A | 3jw3B-3ojlA:undetectable | 3jw3B-3ojlA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3po0 | SMALL ARCHAEALMODIFIER PROTEIN 1 (Haloferaxvolcanii) |
PF02597(ThiS) | 5 | ALA A 13LEU A 5VAL A 36ILE A 57LEU A 53 | None | 1.32A | 3jw3B-3po0A:undetectable | 3jw3B-3po0A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmt | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE 1 (Bacillushalodurans) |
PF00275(EPSP_synthase) | 5 | ALA A 396LEU A 357VAL A 245ILE A 373ILE A 323 | None | 1.15A | 3jw3B-3rmtA:undetectable | 3jw3B-3rmtA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4t | AMIDOHYDROLASE 2 (Polaromonas sp.JS666) |
PF04909(Amidohydro_2) | 5 | ALA A 99VAL A 123ILE A 215LEU A 321ILE A 56 | None | 1.27A | 3jw3B-3s4tA:undetectable | 3jw3B-3s4tA:16.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 5 | ALA A 8LEU A 21ILE A 51LEU A 55ILE A 96 | MTX A2001 ( 3.4A)MTX A2001 (-4.4A)MTX A2001 (-4.3A)MTX A2001 ( 4.5A)MTX A2001 ( 4.2A) | 0.73A | 3jw3B-3tq9A:25.9 | 3jw3B-3tq9A:38.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr7 | URACIL-DNAGLYCOSYLASE (Coxiellaburnetii) |
PF03167(UDG) | 5 | ALA A 208VAL A 121ILE A 95LEU A 113ILE A 63 | None | 1.21A | 3jw3B-3tr7A:undetectable | 3jw3B-3tr7A:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 5 | ALA A 8ILE A 57LEU A 64ILE A 111TYR A 117 | None | 0.95A | 3jw3B-3vcoA:18.1 | 3jw3B-3vcoA:33.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnv | GLYOXYLATE REDUCTASE (Paecilomycessp.'thermophila') |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ALA A 286LEU A 280ILE A 248LEU A 213ILE A 239 | None | 1.27A | 3jw3B-3wnvA:undetectable | 3jw3B-3wnvA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wsv | L-LACTATEDEHYDROGENASE (Enterococcusmundtii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLU A 208VAL A 200ILE A 159LEU A 163ILE A 196 | NoneNoneNoneGOL A 402 (-4.1A)None | 1.28A | 3jw3B-3wsvA:undetectable | 3jw3B-3wsvA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zoq | URACIL-DNAGLYCOSYLASE (Bacillussubtilis) |
PF03167(UDG) | 5 | ALA A 206VAL A 119ILE A 93LEU A 111ILE A 61 | None | 1.21A | 3jw3B-3zoqA:undetectable | 3jw3B-3zoqA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0m | BETAINE ALDEHYDEDEHYDROGENASE,CHLOROPLASTIC (Spinaciaoleracea) |
PF00171(Aldedh) | 5 | LEU A 162VAL A 197ILE A 169LEU A 208ILE A 78 | None | 0.93A | 3jw3B-4a0mA:undetectable | 3jw3B-4a0mA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4amf | PHOX (Pseudomonasfluorescens) |
PF05787(DUF839) | 5 | ALA A 278VAL A 398ILE A 298LEU A 430ILE A 389 | None | 1.32A | 3jw3B-4amfA:undetectable | 3jw3B-4amfA:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b62 | TSSL1 (Pseudomonasaeruginosa) |
PF00691(OmpA) | 5 | ALA A 361LEU A 312ILE A 334LEU A 339ILE A 441 | None | 1.28A | 3jw3B-4b62A:undetectable | 3jw3B-4b62A:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8s | ADP-DEPENDENTGLUCOKINASE (Thermococcuslitoralis) |
PF04587(ADP_PFK_GK) | 5 | ALA A 210VAL A 104ILE A 85LEU A 82ILE A 75 | None | 1.24A | 3jw3B-4b8sA:undetectable | 3jw3B-4b8sA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c5n | PHOSPHOMETHYLPYRIMIDINE KINASE (Staphylococcusaureus) |
PF08543(Phos_pyr_kin) | 5 | ALA A 124LEU A 129ILE A 9LEU A 65ILE A 86 | None | 0.96A | 3jw3B-4c5nA:undetectable | 3jw3B-4c5nA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ern | TFIIH BASALTRANSCRIPTION FACTORCOMPLEX HELICASE XPBSUBUNIT (Homo sapiens) |
PF16203(ERCC3_RAD25_C) | 5 | GLU A 727VAL A 610ILE A 559LEU A 617ILE A 580 | None | 1.12A | 3jw3B-4ernA:undetectable | 3jw3B-4ernA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f9d | POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINEN-DEACETYLASE (Escherichiacoli) |
PF01522(Polysacc_deac_1)PF14883(GHL13) | 5 | ALA A 571LEU A 606VAL A 544LEU A 561ILE A 539 | None | 1.26A | 3jw3B-4f9dA:undetectable | 3jw3B-4f9dA:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwm | PROPIONATE KINASE (Salmonellaenterica) |
PF00871(Acetate_kinase) | 5 | ALA A 312LEU A 342ILE A 304LEU A 204ILE A 210 | None | 1.23A | 3jw3B-4fwmA:undetectable | 3jw3B-4fwmA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8z | DIHYDROFOLATEREDUCTASE (Pneumocystisjirovecii) |
PF00186(DHFR_1) | 6 | ALA X 12LEU X 25GLU X 32ILE X 65ILE X 123TYR X 129 | NDP X 302 ( 3.8A)TOP X 301 ( 4.0A)TOP X 301 (-3.0A)TOP X 301 ( 4.3A)TOP X 301 ( 4.0A)None | 0.72A | 3jw3B-4g8zX:21.2 | 3jw3B-4g8zX:28.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8z | DIHYDROFOLATEREDUCTASE (Pneumocystisjirovecii) |
PF00186(DHFR_1) | 5 | ALA X 12LEU X 25GLU X 32ILE X 65LEU X 72 | NDP X 302 ( 3.8A)TOP X 301 ( 4.0A)TOP X 301 (-3.0A)TOP X 301 ( 4.3A)None | 1.11A | 3jw3B-4g8zX:21.2 | 3jw3B-4g8zX:28.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gg2 | GAMMA-GLUTAMYLTRANSPEPTIDASE 1 HEAVYCHAIN (Homo sapiens) |
PF01019(G_glu_transpept) | 5 | ALA A 106LEU A 91ILE A 69LEU A 73ILE A 138 | None | 1.33A | 3jw3B-4gg2A:undetectable | 3jw3B-4gg2A:18.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h96 | DIHYDROFOLATEREDUCTASE (Candidaalbicans) |
PF00186(DHFR_1) | 6 | ALA A 11GLU A 32ILE A 62LEU A 69ILE A 112TYR A 118 | 14Q A 202 ( 3.7A)14Q A 202 (-2.8A)14Q A 202 ( 4.8A)None14Q A 202 ( 4.2A)None | 0.83A | 3jw3B-4h96A:18.4 | 3jw3B-4h96A:34.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h98 | DIHYDROFOLATEREDUCTASE ([Candida]glabrata) |
PF00186(DHFR_1) | 6 | ALA A 11LEU A 25GLU A 32ILE A 62ILE A 121TYR A 127 | 14Q A 302 ( 3.4A)14Q A 302 ( 4.1A)14Q A 302 (-2.8A)14Q A 302 (-4.2A)14Q A 302 ( 4.0A)None | 0.61A | 3jw3B-4h98A:19.4 | 3jw3B-4h98A:29.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h98 | DIHYDROFOLATEREDUCTASE ([Candida]glabrata) |
PF00186(DHFR_1) | 5 | ALA A 11LEU A 25GLU A 32ILE A 62LEU A 69 | 14Q A 302 ( 3.4A)14Q A 302 ( 4.1A)14Q A 302 (-2.8A)14Q A 302 (-4.2A)None | 0.88A | 3jw3B-4h98A:19.4 | 3jw3B-4h98A:29.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hc6 | HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE (Mycobacteriumtuberculosis) |
PF01648(ACPS) | 5 | ALA A 125LEU A 127VAL A 95ILE A 101ILE A 83 | None | 1.25A | 3jw3B-4hc6A:undetectable | 3jw3B-4hc6A:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzu | ENERGY-COUPLINGFACTOR TRANSPORTERATP-BINDING PROTEINECFA 2 (Lactobacillusbrevis) |
PF00005(ABC_tran) | 5 | GLU A 34VAL A 30ILE A 163LEU A 53ILE A 161 | None | 1.30A | 3jw3B-4hzuA:2.6 | 3jw3B-4hzuA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k9s | GDSL-LIKELIPASE/ACYLHYDROLASEFAMILY PROTEIN (Neisseriameningitidis) |
PF00657(Lipase_GDSL) | 5 | MET A 58ALA A 52VAL A 390ILE A 74LEU A 95 | None | 1.22A | 3jw3B-4k9sA:undetectable | 3jw3B-4k9sA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lyl | URACIL-DNAGLYCOSYLASE (Gadus morhua) |
PF03167(UDG) | 5 | ALA A 287VAL A 200ILE A 173LEU A 192ILE A 141 | None | 1.10A | 3jw3B-4lylA:undetectable | 3jw3B-4lylA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r8x | URICASE (Bacillusfastidiosus) |
PF01014(Uricase) | 5 | ALA A 224LEU A 22GLU A 226VAL A 144TYR A 208 | None | 0.92A | 3jw3B-4r8xA:undetectable | 3jw3B-4r8xA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvh | D-MYCAROSE3-C-METHYLTRANSFERASE (Streptomycesargillaceus) |
PF08421(Methyltransf_13)PF08484(Methyltransf_14)PF13489(Methyltransf_23) | 5 | ALA A 190LEU A 238VAL A 263ILE A 230ILE A 205 | None | 1.23A | 3jw3B-4rvhA:2.5 | 3jw3B-4rvhA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wrw | URACIL-DNAGLYCOSYLASE (Mycobacteriumtuberculosis) |
PF03167(UDG) | 5 | ALA A 210VAL A 123ILE A 97LEU A 115ILE A 64 | None | 1.13A | 3jw3B-4wrwA:undetectable | 3jw3B-4wrwA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0o | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 2 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ALA A 179VAL A 308ILE A 8LEU A 291ILE A 322 | None | 1.33A | 3jw3B-4x0oA:undetectable | 3jw3B-4x0oA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cee | NAD-DEPENDENT MALICENZYME (Aster yellowswitches'-broomphytoplasma) |
PF00390(malic)PF03949(Malic_M) | 5 | ALA A 304LEU A 283ILE A 189LEU A 203ILE A 256 | NoneNAD A 401 (-4.2A)NoneNoneNone | 1.13A | 3jw3B-5ceeA:undetectable | 3jw3B-5ceeA:18.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ecx | DEHYDROFOLATEREDUCTASE TYPE I (Klebsiellapneumoniae) |
PF00186(DHFR_1) | 5 | MET A 5ALA A 7GLU A 27LEU A 53TYR A 102 | 5N1 A 202 (-4.8A)5N1 A 202 ( 3.5A)5N1 A 202 (-2.5A)5N1 A 202 ( 4.7A)None | 0.41A | 3jw3B-5ecxA:23.7 | 3jw3B-5ecxA:31.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ez3 | ACYL-COADEHYDROGENASE (Brucellamelitensis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M) | 5 | ALA A 480LEU A 498ILE A 462LEU A 466ILE A 474 | None | 1.23A | 3jw3B-5ez3A:undetectable | 3jw3B-5ez3A:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5n | LH3HEXON-INTERLACINGCAPSID PROTEIN (Snakeatadenovirus A) |
PF01696(Adeno_E1B_55K) | 5 | ALA A 40VAL A 60ILE A 98LEU A 125ILE A 62 | None | 0.99A | 3jw3B-5g5nA:undetectable | 3jw3B-5g5nA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hhl | RETRON-TYPE REVERSETRANSCRIPTASE ([Eubacterium]rectale) |
PF00078(RVT_1) | 5 | LEU A 198VAL A 167ILE A 90LEU A 55ILE A 10 | None | 1.18A | 3jw3B-5hhlA:undetectable | 3jw3B-5hhlA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 5 | MET A 422LEU A 391VAL A 371ILE A 358ILE A 424 | None | 1.25A | 3jw3B-5jfmA:undetectable | 3jw3B-5jfmA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jkj | ESTERASE E22 (unculturedbacterium) |
PF00561(Abhydrolase_1) | 5 | ALA A 170LEU A 391VAL A 108ILE A 94ILE A 67 | None | 1.30A | 3jw3B-5jkjA:undetectable | 3jw3B-5jkjA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jp0 | BETA-GLUCOSIDASEBOGH3B (Bacteroidesovatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ALA A 444LEU A 477VAL A 565ILE A 431LEU A 429 | None | 1.27A | 3jw3B-5jp0A:undetectable | 3jw3B-5jp0A:12.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7q | PUTATIVE CATHEPSIN D (Ixodes ricinus) |
no annotation | 5 | ALA A 98VAL A 140ILE A 24LEU A 105ILE A 22 | None | 1.16A | 3jw3B-5n7qA:undetectable | 3jw3B-5n7qA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n8o | DNA HELICASE I (Escherichiacoli) |
PF07057(TraI)PF08751(TrwC)PF13604(AAA_30) | 5 | ALA A1288LEU A1309GLU A1327ILE A1300LEU A1277 | None | 1.28A | 3jw3B-5n8oA:undetectable | 3jw3B-5n8oA:6.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nn7 | URACIL-DNAGLYCOSYLASE (Humangammaherpesvirus8) |
no annotation | 5 | ALA A 236VAL A 142ILE A 115LEU A 134ILE A 84 | None | 1.21A | 3jw3B-5nn7A:undetectable | 3jw3B-5nn7A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nth | PUTATIVEAMINOPEPTIDASE (Leishmaniamajor) |
PF00883(Peptidase_M17) | 5 | MET A 417VAL A 329ILE A 294LEU A 536ILE A 415 | None | 1.29A | 3jw3B-5nthA:undetectable | 3jw3B-5nthA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0j | ADP-DEPENDENTGLUCOKINASE (Pyrococcushorikoshii) |
no annotation | 5 | ALA A 205VAL A 99ILE A 80LEU A 77ILE A 70 | None | 1.21A | 3jw3B-5o0jA:undetectable | 3jw3B-5o0jA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uto | EDD DOMAIN PROTEIN,DEGV FAMILY (Staphylococcusaureus) |
no annotation | 5 | ALA A 122VAL A 267ILE A 198LEU A 168ILE A 94 | PLM A 301 ( 4.5A)PLM A 301 (-4.3A)NoneNonePLM A 301 (-4.2A) | 1.29A | 3jw3B-5utoA:undetectable | 3jw3B-5utoA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ar3 | GSI-IIC RT (Geobacillusstearothermophilus) |
no annotation | 5 | LEU A 195VAL A 164ILE A 87LEU A 52ILE A 7 | None | 1.26A | 3jw3B-6ar3A:undetectable | 3jw3B-6ar3A:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bj9 | ACETYL-COAACETYLTRANSFERASE A (Ascaris suum) |
no annotation | 5 | MET A 275ALA A 273LEU A 365ILE A 310ILE A 386 | None | 1.09A | 3jw3B-6bj9A:undetectable | 3jw3B-6bj9A:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e4e | - (-) |
no annotation | 5 | ALA A 7LEU A 20VAL A 31ILE A 50LEU A 54 | MMV A 202 ( 3.5A)MMV A 202 (-4.3A)MMV A 202 (-4.9A)MMV A 202 ( 4.9A)None | 0.57A | 3jw3B-6e4eA:26.2 | 3jw3B-6e4eA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ehi | NUCLEASE NUCT (Helicobacterpylori) |
no annotation | 5 | ALA A 48LEU A 74VAL A 28ILE A 40ILE A 21 | None | 1.28A | 3jw3B-6ehiA:undetectable | 3jw3B-6ehiA:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gef | TYPE IV SECRETIONSYSTEM PROTEIN DOTB (Yersiniapseudotuberculosis) |
no annotation | 5 | ALA A 25ILE A 50LEU A 66ILE A 74TYR A 98 | ALA A 25 ( 0.0A)ILE A 50 ( 0.7A)LEU A 66 ( 0.5A)ILE A 74 ( 0.7A)TYR A 98 ( 1.3A) | 1.27A | 3jw3B-6gefA:undetectable | 3jw3B-6gefA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gxz | - (-) |
no annotation | 5 | LEU D 255VAL D 281ILE D 259LEU D 220ILE D 239 | None | 1.03A | 3jw3B-6gxzD:undetectable | 3jw3B-6gxzD:undetectable |