SIMILAR PATTERNS OF AMINO ACIDS FOR 3JUS_B_ECLB600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 TYR A 225
THR A 223
TYR A 236
GLY A 220
 None
 0.78A 3jusB-1axkA:
0.0		 3jusB-1axkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 TYR A 272
GLY A 171
ALA A 155
ILE A 288
 None
 0.70A 3jusB-1b0kA:
0.0		 3jusB-1b0kA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		4 TYR B 274
GLY A 223
THR A 204
ILE A 199
 None
 0.81A 3jusB-1b5fB:
0.0		 3jusB-1b5fB:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		4 LEU A  71
GLY A 194
ALA A  77
ILE A  84
 None
PLP  A 363 ( 4.6A)
PLP  A 363 (-3.5A)
None
 0.63A 3jusB-1bt4A:
0.0		 3jusB-1bt4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 493
GLY A  23
ALA A  26
ILE A 501
 None
 0.83A 3jusB-1coyA:
0.0		 3jusB-1coyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbh PROTEIN (HUMAN SOS
1)

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 TYR A 353
LEU A 380
ALA A 299
ILE A 252
 None
 0.82A 3jusB-1dbhA:
0.3		 3jusB-1dbhA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 GLY A 343
ALA A 347
THR A 351
ILE A 356
 None
 0.49A 3jusB-1dl2A:
0.3		 3jusB-1dl2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 LEU A 247
THR A 248
GLY A 262
ALA A 280
 None
 0.79A 3jusB-1dl5A:
0.0		 3jusB-1dl5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 THR A 186
GLY A  86
ALA A  89
THR A  93
ILE A 182
 PLP  A 405 (-3.8A)
PLP  A 405 (-3.1A)
None
None
None
 1.43A 3jusB-1e5fA:
undetectable		 3jusB-1e5fA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 TYR B  78
LEU B 406
GLY B 354
ILE B 415
 None
 0.80A 3jusB-1e9yB:
undetectable		 3jusB-1e9yB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.) 		PF01979
(Amidohydro_1) 		4 TYR A  17
GLY A  48
ALA A  46
ILE A  21
 None
 0.80A 3jusB-1gkpA:
undetectable		 3jusB-1gkpA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		4 LEU A 108
GLY A  24
ALA A  26
ILE A 230
 None
 0.80A 3jusB-1gnzA:
undetectable		 3jusB-1gnzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu8 CELLULAR TUMOR
ANTIGEN P53

(Mus musculus) 		PF00870
(P53) 		4 TYR A 202
LEU A 203
ALA A 158
THR A 250
 None
 0.81A 3jusB-1hu8A:
undetectable		 3jusB-1hu8A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ih5 AQUAPORIN-1

(Homo sapiens) 		PF00230
(MIP) 		4 LEU A  54
GLY A  30
ALA A  32
ILE A 184
 None
 0.66A 3jusB-1ih5A:
undetectable		 3jusB-1ih5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		4 LEU A 325
THR A 326
GLY A 251
ILE A 298
 None
 0.79A 3jusB-1jqkA:
0.7		 3jusB-1jqkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 212
GLY A 192
ALA A 275
ILE A 157
 None
 0.78A 3jusB-1lpfA:
undetectable		 3jusB-1lpfA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		5 LEU A 315
THR A 257
GLY A 305
THR A 353
ILE A 373
 None
PLP  A1110 (-3.3A)
PLP  A1110 (-3.9A)
None
None
 1.24A 3jusB-1m54A:
undetectable		 3jusB-1m54A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mab PROTEIN (F1-ATPASE
BETA CHAIN)
PROTEIN (F1-ATPASE
GAMMA CHAIN)

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00231
(ATP-synt)
PF02874
(ATP-synt_ab_N) 		5 LEU B 391
GLY G  76
ALA G 228
THR G  17
ILE G  13
 None
 1.12A 3jusB-1mabB:
undetectable		 3jusB-1mabB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		4 THR D 213
GLY D 113
ALA D 117
THR D 121
 None
 0.76A 3jusB-1mtyD:
undetectable		 3jusB-1mtyD:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		4 LEU A 219
TYR A 191
GLY A  78
ILE A 164
 None
 0.82A 3jusB-1n97A:
37.4		 3jusB-1n97A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii) 		PF00331
(Glyco_hydro_10) 		4 LEU A 283
GLY A 242
ALA A 246
THR A 250
 None
 0.85A 3jusB-1nq6A:
undetectable		 3jusB-1nq6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 TYR A 316
LEU A 354
GLY A 343
ALA A 345
THR A  14
 None
 1.45A 3jusB-1o4sA:
undetectable		 3jusB-1o4sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 LEU A 321
THR A 320
GLY A 298
ILE A 276
 None
 0.85A 3jusB-1pguA:
undetectable		 3jusB-1pguA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		4 TYR A  13
LEU A  49
GLY A  19
ILE A  40
 None
 0.81A 3jusB-1pmiA:
undetectable		 3jusB-1pmiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 LEU A  11
THR A  10
GLY A  33
ILE A 348
 None
 0.82A 3jusB-1pojA:
undetectable		 3jusB-1pojA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 TYR A 266
GLY A 423
ALA A 427
ILE A 368
 None
 0.84A 3jusB-1pw4A:
undetectable		 3jusB-1pw4A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 LEU A 174
GLY A 115
ALA A 207
ILE A 150
 None
 0.00A 3jusB-1q5aA:
undetectable		 3jusB-1q5aA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 LEU A 635
THR A 634
ALA A 586
ILE A 554
 None
 0.83A 3jusB-1qgrA:
undetectable		 3jusB-1qgrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13183
(Fer4_8) 		4 LEU A 268
THR A 269
ALA A  47
ILE B  61
 None
FUM  A1657 (-4.5A)
FAD  A1656 (-3.6A)
None
 0.81A 3jusB-1qlbA:
undetectable		 3jusB-1qlbA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A) 		PF00073
(Rhv) 		5 LEU 3  52
THR 3  51
GLY 3 100
ALA 3  95
ILE 1 278
 None
 1.18A 3jusB-1r1a3:
undetectable		 3jusB-1r1a3:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 LEU A  32
THR A  31
GLY A 169
ILE A 143
 None
 0.83A 3jusB-1rxwA:
undetectable		 3jusB-1rxwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY B 682
ALA B 686
THR B 690
ILE B 380
 None
 0.76A 3jusB-1t3qB:
1.1		 3jusB-1t3qB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 2

(Bos taurus) 		PF00022
(Actin) 		4 THR B 164
GLY B 277
ALA B 279
ILE B 344
 None
 0.83A 3jusB-1u2vB:
undetectable		 3jusB-1u2vB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 TYR A  92
THR A  90
GLY A 153
THR A 208
 SO4  A1433 ( 4.8A)
None
None
None
 0.75A 3jusB-1uypA:
undetectable		 3jusB-1uypA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 LEU A 178
GLY A 203
ALA A 156
ILE A 168
 None
 0.79A 3jusB-1vbmA:
undetectable		 3jusB-1vbmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		4 LEU B 355
THR B 354
GLY B 350
ILE B 309
 None
 0.65A 3jusB-1vraB:
undetectable		 3jusB-1vraB:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 LEU A 333
THR A 334
ALA A 323
THR A 327
 None
 0.81A 3jusB-1vrqA:
undetectable		 3jusB-1vrqA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 355
GLY A 117
ALA A 259
THR A  16
ILE A  18
 CSO  A  92 ( 4.6A)
None
None
None
None
 1.24A 3jusB-1wl4A:
undetectable		 3jusB-1wl4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 275
THR A 276
GLY A 106
ALA A 104
THR A 198
 None
 1.35A 3jusB-1wwkA:
undetectable		 3jusB-1wwkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 TYR A 353
LEU A 380
ALA A 299
ILE A 252
 None
 0.82A 3jusB-1xdvA:
undetectable		 3jusB-1xdvA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2f CELL DIVISION
PROTEIN ZIPA

(Escherichia
coli) 		PF04354
(ZipA_C) 		5 LEU A  23
THR A  79
GLY A  68
ALA A  62
ILE A  84
 None
None
WAI  A 300 ( 4.2A)
WAI  A 300 (-3.5A)
None
 1.35A 3jusB-1y2fA:
undetectable		 3jusB-1y2fA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM

(Thermoplasma
acidophilum) 		PF01729
(QRPTase_C) 		4 LEU A 171
GLY A 162
ALA A 160
ILE A 119
 None
 0.82A 3jusB-1ytkA:
undetectable		 3jusB-1ytkA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw0 TRYPTOPHAN
2,3-DIOXYGENASE

(Xanthomonas
campestris) 		PF03301
(Trp_dioxygenase) 		4 LEU A 108
THR A 107
THR A  57
ILE A  53
 None
 0.70A 3jusB-1yw0A:
undetectable		 3jusB-1yw0A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 THR A  63
GLY A 335
ALA A 216
THR A 194
 None
 0.73A 3jusB-1z1eA:
undetectable		 3jusB-1z1eA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 TYR A 164
THR A 166
GLY A 182
ALA A  68
 None
PCA  A   1 ( 4.9A)
PCA  A   1 ( 3.3A)
PCA  A   1 ( 3.7A)
 0.72A 3jusB-1z3vA:
undetectable		 3jusB-1z3vA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 TYR A 308
LEU A 309
THR A 310
ILE A 282
 None
 0.73A 3jusB-2abjA:
undetectable		 3jusB-2abjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		4 GLY A 182
ALA A 180
THR A  85
ILE A  89
 None
SO4  A1001 ( 4.6A)
SO4  A1001 (-2.7A)
None
 0.81A 3jusB-2aeuA:
undetectable		 3jusB-2aeuA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		5 TYR A 281
TYR A 370
GLY A  44
THR A 205
ILE A  61
 FAD  A 500 ( 4.6A)
FAD  A 500 ( 4.5A)
FAD  A 500 (-3.5A)
None
FAD  A 500 (-4.5A)
 1.46A 3jusB-2bacA:
undetectable		 3jusB-2bacA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgo ENDO-B1,4-MANNANASE
5C

(Cellvibrio
japonicus) 		PF16990
(CBM_35) 		4 LEU A  67
THR A  66
GLY A 105
THR A  19
 None
 0.74A 3jusB-2bgoA:
undetectable		 3jusB-2bgoA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		4 THR A  96
GLY A  43
ALA A  46
ILE A  85
 None
ADN  A1301 (-3.3A)
None
None
 0.82A 3jusB-2c49A:
undetectable		 3jusB-2c49A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 281
THR A 278
GLY A 206
ALA A 359
 None
 0.85A 3jusB-2cb1A:
undetectable		 3jusB-2cb1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chq REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 THR A  49
GLY A  21
ALA A 165
ILE A 190
 ANP  A 700 (-4.9A)
None
None
None
 0.80A 3jusB-2chqA:
undetectable		 3jusB-2chqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN

(Cryptococcus
sp. S-2) 		PF01083
(Cutinase) 		4 LEU A  81
GLY A 193
THR A  35
ILE A  43
 None
 0.80A 3jusB-2czqA:
undetectable		 3jusB-2czqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1f THREONINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 LEU A 273
GLY A 196
THR A 245
ILE A 280
 None
PLP  A 500 (-3.6A)
None
None
 0.82A 3jusB-2d1fA:
undetectable		 3jusB-2d1fA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea) 		PF00139
(Lectin_legB) 		4 LEU A 229
GLY A 144
ALA A 146
ILE A 106
 None
 0.84A 3jusB-2d3rA:
undetectable		 3jusB-2d3rA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TYR A 721
THR A 725
ALA A 542
THR A 500
 None
 0.82A 3jusB-2d5lA:
undetectable		 3jusB-2d5lA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN

(Pyrococcus
horikoshii) 		PF00574
(CLP_protease) 		5 LEU A 150
GLY A 118
ALA A  96
THR A  62
ILE A  33
 None
 1.41A 3jusB-2deoA:
undetectable		 3jusB-2deoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 LEU A 318
THR A 317
TYR A 460
ALA A 388
 None
 0.78A 3jusB-2dkdA:
undetectable		 3jusB-2dkdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE

(Rhizobium sp.
MTP-10005) 		PF04909
(Amidohydro_2) 		5 LEU A 283
THR A 260
GLY A 263
ALA A 296
ILE A  52
 None
 1.09A 3jusB-2dvuA:
undetectable		 3jusB-2dvuA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		4 TYR A  40
LEU A  41
GLY A  28
ILE A 174
 None
 0.84A 3jusB-2e18A:
undetectable		 3jusB-2e18A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		4 LEU A 154
GLY A 537
THR A 453
ILE A 458
 None
 0.71A 3jusB-2et6A:
undetectable		 3jusB-2et6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 LEU A  87
GLY A 201
ALA A  75
ILE A  36
 None
 0.80A 3jusB-2exrA:
undetectable		 3jusB-2exrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Bacillus cereus) 		PF02457
(DisA_N)
PF10372
(YojJ) 		4 LEU A 154
THR A 155
GLY A 198
ALA A 195
 None
 0.82A 3jusB-2fb5A:
undetectable		 3jusB-2fb5A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j85 STIV B116

(Sulfolobus
turreted
icosahedral
virus 1) 		PF08960
(DUF1874) 		5 LEU A  57
THR A  54
GLY A  50
ALA A  48
ILE A  83
 None
 1.43A 3jusB-2j85A:
undetectable		 3jusB-2j85A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbr P-HYDROXYPHENYLACETA
TE HYDROXYLASE C2
OXYGENASE COMPONENT

(Acinetobacter
baumannii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 THR A 143
GLY A 172
ALA A 113
ILE A 100
 None
 0.85A 3jusB-2jbrA:
undetectable		 3jusB-2jbrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 349
THR A 350
GLY A 303
ALA A 305
THR A 381
 None
 1.33A 3jusB-2jifA:
0.0		 3jusB-2jifA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 TYR A 173
LEU A 177
THR A 174
GLY A 128
ALA A 131
 None
 1.20A 3jusB-2jjfA:
0.5		 3jusB-2jjfA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1s UNCHARACTERIZED
PROTEIN YOHN

(Klebsiella
pneumoniae) 		PF11776
(RcnB) 		4 TYR A  30
LEU A  31
THR A  32
TYR A  35
 None
 0.81A 3jusB-2l1sA:
undetectable		 3jusB-2l1sA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		5 LEU A 401
THR A 398
GLY A 390
ALA A 388
THR A 331
 None
 1.33A 3jusB-2oceA:
0.3		 3jusB-2oceA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		5 TYR A 283
GLY A 208
ALA A 178
THR A 182
ILE A 125
 None
 1.15A 3jusB-2oryA:
0.6		 3jusB-2oryA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		4 LEU A 230
GLY A 144
ALA A 146
ILE A 106
 None
 0.82A 3jusB-2ow4A:
undetectable		 3jusB-2ow4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF01872
(RibD_C) 		5 THR A  81
TYR A  87
GLY A  54
THR A 214
ILE A  38
 EDO  A 284 ( 3.5A)
EDO  A 271 ( 4.0A)
None
None
EDO  A 278 (-4.7A)
 1.34A 3jusB-2p4gA:
undetectable		 3jusB-2p4gA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 LEU A  13
THR A  12
GLY A 450
ILE A  68
 None
 0.68A 3jusB-2pajA:
undetectable		 3jusB-2pajA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmo DETHIOBIOTIN
SYNTHETASE

(Helicobacter
pylori) 		PF13500
(AAA_26) 		4 LEU A 121
ALA A  80
THR A  39
ILE A  37
 None
 0.77A 3jusB-2qmoA:
undetectable		 3jusB-2qmoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		4 LEU A  10
THR A   9
GLY A  34
ILE A 375
 None
 0.79A 3jusB-2qs8A:
undetectable		 3jusB-2qs8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		5 LEU A  10
THR A   9
GLY A 407
ALA A 381
ILE A 375
 None
 1.34A 3jusB-2qs8A:
undetectable		 3jusB-2qs8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r79 PERIPLASMIC BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF01497
(Peripla_BP_2) 		4 THR A  56
TYR A  71
GLY A 267
ILE A 173
 None
HEM  A 500 (-3.6A)
None
HEM  A 500 ( 4.1A)
 0.71A 3jusB-2r79A:
undetectable		 3jusB-2r79A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		5 LEU A 203
THR A 120
TYR A 218
GLY A 232
ALA A 117
 None
 1.45A 3jusB-2rinA:
undetectable		 3jusB-2rinA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sxl SEX-LETHAL PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		4 TYR A  47
LEU A  11
TYR A  45
GLY A  42
 None
 0.83A 3jusB-2sxlA:
undetectable		 3jusB-2sxlA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8n LACTOSE PERMEASE

(Escherichia
coli) 		PF01306
(LacY_symp) 		5 LEU A 400
GLY A 391
ALA A 389
THR A 235
ILE A 230
 None
 1.44A 3jusB-2v8nA:
undetectable		 3jusB-2v8nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A 774
THR A 770
GLY A 765
THR A 675
ILE A 679
 None
 1.42A 3jusB-2vdaA:
0.0		 3jusB-2vdaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A 128
GLY A  58
ALA A  62
THR A  66
 ACT  A1519 (-4.7A)
DDZ  A  57 ( 2.4A)
None
None
 0.74A 3jusB-2vqrA:
undetectable		 3jusB-2vqrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  39
THR A  81
ALA A   5
ILE A  25
 None
 0.83A 3jusB-2w5hA:
undetectable		 3jusB-2w5hA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 THR A 109
GLY A  58
ALA A  62
THR A  66
 None
FGL  A  57 ( 2.7A)
None
None
 0.80A 3jusB-2w8sA:
undetectable		 3jusB-2w8sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4

(Homo sapiens) 		PF01454
(MAGE) 		4 TYR A 240
LEU A 246
THR A 209
ILE A 205
 None
 0.82A 3jusB-2wa0A:
undetectable		 3jusB-2wa0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		5 TYR A  89
LEU A 143
THR A 140
GLY A 127
ILE A 147
 None
 1.08A 3jusB-2x2iA:
undetectable		 3jusB-2x2iA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		5 THR A 197
GLY A 185
ALA A 183
THR A  81
ILE A  85
 None
None
PLP  A1211 (-3.4A)
PLP  A1211 (-3.8A)
None
 1.25A 3jusB-2x3lA:
undetectable		 3jusB-2x3lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 5 LEU A 357
THR A 352
TYR A 351
GLY A 268
ALA A 132
 None
 1.48A 3jusB-2y4lA:
undetectable		 3jusB-2y4lA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 LEU A 657
GLY A 616
ALA A 474
ILE A 322
 None
FAD  A 801 (-3.8A)
None
None
 0.81A 3jusB-2yr5A:
undetectable		 3jusB-2yr5A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN

(Thermotoga
maritima) 		PF01887
(SAM_adeno_trans) 		4 LEU A   5
THR A   6
GLY A 128
ALA A 133
 None
 0.80A 3jusB-2zbvA:
undetectable		 3jusB-2zbvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN

(Thermotoga
maritima) 		PF01887
(SAM_adeno_trans) 		4 THR A   6
GLY A 128
ALA A 133
ILE A  31
 None
 0.67A 3jusB-2zbvA:
undetectable		 3jusB-2zbvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze3 DFA0005

(Deinococcus
ficus) 		PF13714
(PEP_mutase) 		5 LEU A 240
THR A 239
ALA A  23
THR A  42
ILE A  47
 None
 1.41A 3jusB-2ze3A:
undetectable		 3jusB-2ze3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 THR A 189
GLY A 242
ALA A 240
ILE A 185
 None
 0.78A 3jusB-3actA:
undetectable		 3jusB-3actA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		4 LEU A 584
GLY A 590
ALA A 593
ILE A  42
 None
 0.81A 3jusB-3agrA:
undetectable		 3jusB-3agrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 TYR A 301
LEU A 304
GLY A 326
ALA A 322
 None
 0.79A 3jusB-3auoA:
undetectable		 3jusB-3auoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 LEU A 177
THR A 176
GLY A 168
ALA A 162
 None
 0.85A 3jusB-3bqyA:
undetectable		 3jusB-3bqyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbu PROBABLE GST-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 TYR A  97
LEU A 100
THR A 101
TYR A 130
 None
 0.73A 3jusB-3cbuA:
undetectable		 3jusB-3cbuA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg4 RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY-LIKE)

(Methanospirillum
hungatei) 		PF00072
(Response_reg) 		4 LEU A  85
THR A  86
TYR A 105
ILE A  68
 None
None
GOL  A 203 ( 4.9A)
None
 0.82A 3jusB-3cg4A:
undetectable		 3jusB-3cg4A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 THR A 400
GLY A  32
ALA A  34
THR A  44
ILE A  42
 None
 1.21A 3jusB-3da1A:
undetectable		 3jusB-3da1A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3din PREPROTEIN
TRANSLOCASE SUBUNIT
SECE
PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Thermotoga
maritima) 		PF00344
(SecY)
PF00584
(SecE) 		5 LEU C 224
GLY C 400
ALA C 402
THR D  40
ILE D  36
 None
 1.09A 3jusB-3dinC:
undetectable		 3jusB-3dinC:
22.40