SIMILAR PATTERNS OF AMINO ACIDS FOR 3JQ7_C_DX2C270_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 PHE A 401
ASP A 257
TYR A 269
PRO A 404
 None
 1.02A 3jq7C-1cpyA:
4.3		 3jq7C-1cpyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		4 ASP A 124
TYR A 144
VAL A  82
LEU A 119
 None
 1.11A 3jq7C-1edgA:
2.3		 3jq7C-1edgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 SER A 160
ASP A  46
VAL A 187
LEU A 175
 None
 1.07A 3jq7C-1eizA:
8.8		 3jq7C-1eizA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exs BETA-LACTOGLOBULIN

(Sus scrofa) 		PF00061
(Lipocalin) 		4 ARG A 133
VAL A  26
LEU A 150
PRO A 151
 None
 0.97A 3jq7C-1exsA:
undetectable		 3jq7C-1exsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0n TRIHYDROXYNAPHTHALEN
E REDUCTASE

(Magnaporthe
grisea) 		PF13561
(adh_short_C2) 		4 SER A 164
VAL A 249
LEU A 251
PRO A 252
 PHH  A 402 (-2.2A)
None
None
None
 0.81A 3jq7C-1g0nA:
30.5		 3jq7C-1g0nA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 SER A 106
ASP A 101
VAL A  95
LEU A 119
 None
 1.11A 3jq7C-1g68A:
undetectable		 3jq7C-1g68A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		4 SER A 311
VAL A  21
LEU A 146
PRO A 147
 ZN  A1200 ( 2.4A)
NAD  A1000 ( 4.8A)
None
NAD  A1000 (-4.1A)
 1.03A 3jq7C-1gr0A:
8.3		 3jq7C-1gr0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 PHE A 499
ASP A 518
TYR A 496
LEU A 538
 None
 1.13A 3jq7C-1gxlA:
undetectable		 3jq7C-1gxlA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 ASP A 136
TYR A  27
VAL A 207
LEU A 260
 AMI  A1388 ( 4.9A)
AMI  A1388 (-3.6A)
None
None
 1.09A 3jq7C-1hkkA:
2.3		 3jq7C-1hkkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		4 ASP A 350
TYR A 223
VAL A 345
LEU A 209
 None
 0.96A 3jq7C-1hxjA:
3.1		 3jq7C-1hxjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 SER A 272
PHE A 245
VAL A 257
PRO A 251
 None
 1.12A 3jq7C-1iirA:
7.9		 3jq7C-1iirA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Homo sapiens) 		PF01536
(SAM_decarbox) 		4 SER A 109
ASP A 174
TYR A 318
LEU A  13
 None
PUT  A 401 (-3.4A)
PUT  A 401 (-4.0A)
PUT  A 401 (-4.4A)
 1.04A 3jq7C-1jl0A:
undetectable		 3jq7C-1jl0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 SER A 105
VAL A 312
LEU A 318
PRO A 319
 None
 1.10A 3jq7C-1kk0A:
3.6		 3jq7C-1kk0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		4 PHE A6025
TYR A6214
VAL A6127
PRO A6066
 None
 1.15A 3jq7C-1koaA:
undetectable		 3jq7C-1koaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 SER A1021
VAL A1028
LEU A1134
PRO A1026
 None
 1.00A 3jq7C-1lu4A:
undetectable		 3jq7C-1lu4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7h ADENYLYLSULFATE
KINASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase) 		4 SER A 107
PHE A 105
VAL A  90
LEU A  69
 None
SO4  A1002 (-4.8A)
None
None
 1.13A 3jq7C-1m7hA:
5.2		 3jq7C-1m7hA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H 385
VAL H 354
LEU H 391
PRO H 381
 None
 1.15A 3jq7C-1mcoH:
undetectable		 3jq7C-1mcoH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 ARG A 285
TYR A 335
VAL A 291
PRO A 287
 None
 1.13A 3jq7C-1mdwA:
undetectable		 3jq7C-1mdwA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mv5 MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Lactococcus
lactis) 		PF00005
(ABC_tran) 		4 SER A 387
PHE A 386
VAL A 422
LEU A 502
 None
 1.13A 3jq7C-1mv5A:
undetectable		 3jq7C-1mv5A:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		6 ARG A  22
SER A 103
ASP A 169
TYR A 182
LEU A 217
PRO A 218
 NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
NDP  A1277 (-3.9A)
MTX  A1278 ( 4.7A)
None
MTX  A1278 ( 4.1A)
 0.34A 3jq7C-1mxfA:
41.3		 3jq7C-1mxfA:
56.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 ASP A 558
TYR A 199
VAL A 562
LEU A 509
 None
 1.16A 3jq7C-1obhA:
undetectable		 3jq7C-1obhA:
15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		7 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
PRO A 230
 NDP  A 300 ( 3.7A)
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
NDP  A 300 ( 3.7A)
MTX  A 351 ( 4.4A)
MTX  A 351 (-4.9A)
MTX  A 351 (-3.3A)
 0.31A 3jq7C-1p33A:
40.0		 3jq7C-1p33A:
48.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pio BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		4 SER A 106
ASP A 101
VAL A  95
LEU A 119
 None
 1.06A 3jq7C-1pioA:
undetectable		 3jq7C-1pioA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq6 PROTEIN
(L-2-HALOACID
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00702
(Hydrolase) 		4 ASP A 176
TYR A 153
VAL A 170
LEU A 168
 ASB  A   8 ( 4.0A)
None
None
None
 1.08A 3jq7C-1qq6A:
5.8		 3jq7C-1qq6A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE

(Rattus
norvegicus) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 SER A   9
PHE A  11
VAL A  82
LEU A  19
 None
 1.14A 3jq7C-1s3iA:
7.7		 3jq7C-1s3iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfn CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF05899
(Cupin_3) 		4 PHE A1163
VAL A1096
LEU A1098
PRO A1099
 None
 1.03A 3jq7C-1sfnA:
undetectable		 3jq7C-1sfnA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 PHE A 701
VAL A 681
LEU A 501
PRO A 500
 None
 0.98A 3jq7C-1suvA:
undetectable		 3jq7C-1suvA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN
RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF00101
(RuBisCO_small)
PF02788
(RuBisCO_large_N) 		4 ARG M 108
VAL A 415
LEU M  19
PRO M  20
 None
 1.06A 3jq7C-1svdM:
undetectable		 3jq7C-1svdM:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t04 HUZAF ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER B 134
VAL B 188
LEU B 142
PRO B 130
 None
 1.12A 3jq7C-1t04B:
undetectable		 3jq7C-1t04B:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1th8 ANTI-SIGMA F FACTOR
ANTAGONIST

(Geobacillus
stearothermophilus) 		PF01740
(STAS) 		4 SER B  94
PHE B  91
VAL B  63
LEU B  22
 None
 0.91A 3jq7C-1th8B:
3.9		 3jq7C-1th8B:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 SER A  19
PHE A  23
VAL A  92
LEU A  67
 None
 1.15A 3jq7C-1uagA:
3.3		 3jq7C-1uagA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 OUTER CAPSID PROTEIN
P8

(Rice dwarf
virus) 		no annotation 4 ASP P 321
TYR P 307
VAL P 325
LEU P 132
 None
 0.75A 3jq7C-1uf2P:
undetectable		 3jq7C-1uf2P:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ARG A 128
SER A 131
VAL A 120
LEU A 153
 None
 1.12A 3jq7C-1up4A:
7.2		 3jq7C-1up4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v29 NITRILE HYDRATASE A
CHAIN
NITRILE HYDRATASE B
CHAIN

(Bacillus
smithii) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 SER A 175
TYR B 176
VAL A 107
LEU A  92
 None
 1.06A 3jq7C-1v29A:
undetectable		 3jq7C-1v29A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 SER A 217
PHE A 215
VAL A 242
LEU A 207
 None
 1.07A 3jq7C-1vbgA:
2.3		 3jq7C-1vbgA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965

(Mycobacterium
tuberculosis) 		PF01068
(DNA_ligase_A_M)
PF04679
(DNA_ligase_A_C) 		4 SER A 607
PHE A 604
VAL A 634
LEU A 471
 None
 0.97A 3jq7C-1vs0A:
undetectable		 3jq7C-1vs0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 ASP A 136
TYR A  27
VAL A 207
LEU A 260
 None
 1.10A 3jq7C-1wb0A:
4.1		 3jq7C-1wb0A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 SER A 146
ASP A 177
VAL A 199
LEU A 226
 None
 0.94A 3jq7C-1wpwA:
undetectable		 3jq7C-1wpwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		4 PHE A  35
ASP A  44
VAL A  57
LEU A  48
 None
 1.13A 3jq7C-1wraA:
undetectable		 3jq7C-1wraA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		4 ARG A 322
SER A 222
LEU A 293
PRO A 294
 None
 0.91A 3jq7C-1xfiA:
2.6		 3jq7C-1xfiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xio ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		4 TYR A  73
VAL A 182
LEU A 205
PRO A 206
 None
None
None
RET  A 301 ( 4.7A)
 1.03A 3jq7C-1xioA:
undetectable		 3jq7C-1xioA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 SER B 133
PHE B 131
VAL B 116
LEU B  95
 None
ADX  B2805 (-4.6A)
None
None
 1.04A 3jq7C-1xnjB:
4.5		 3jq7C-1xnjB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 SER A 433
ASP A 378
VAL A 306
LEU A 227
 None
 0.94A 3jq7C-1yq2A:
2.4		 3jq7C-1yq2A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		4 SER A 289
ASP A 221
LEU A 203
PRO A 204
 None
 1.07A 3jq7C-1zkdA:
4.9		 3jq7C-1zkdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		4 PHE A 125
VAL A  48
LEU A 136
PRO A 123
 None
 1.15A 3jq7C-1zy9A:
2.9		 3jq7C-1zy9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arz HYPOTHETICAL PROTEIN
PA4388

(Pseudomonas
aeruginosa) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		4 SER A 113
PHE A 110
TYR A 106
VAL A  36
 None
None
None
GOL  A2648 ( 4.6A)
 1.09A 3jq7C-2arzA:
undetectable		 3jq7C-2arzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2

(Homo sapiens) 		PF01583
(APS_kinase) 		4 SER A 133
PHE A 131
VAL A 116
LEU A  95
 None
 1.04A 3jq7C-2ax4A:
5.2		 3jq7C-2ax4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 SER A 373
PHE A 220
VAL A 430
PRO A 425
 None
 0.97A 3jq7C-2bf4A:
3.5		 3jq7C-2bf4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		4 PHE A  10
ASP A  19
VAL A  32
LEU A  23
 None
 1.14A 3jq7C-2bibA:
2.4		 3jq7C-2bibA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byf PHOSPHOLIPASE C,
EPSILON 1

(Homo sapiens) 		PF00788
(RA) 		4 SER A  45
VAL A  22
LEU A  20
PRO A  19
 None
 1.15A 3jq7C-2byfA:
undetectable		 3jq7C-2byfA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 SER A 243
PHE A 244
TYR A 252
VAL A 261
 None
 1.10A 3jq7C-2c0yA:
undetectable		 3jq7C-2c0yA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9j GREEN FLUORESCENT
PROTEIN FP512

(Cerianthus
membranaceus) 		PF01353
(GFP) 		4 PHE A  79
VAL A 152
LEU A 186
PRO A 187
 None
 1.14A 3jq7C-2c9jA:
undetectable		 3jq7C-2c9jA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A  38
ASP A  79
VAL A  83
LEU A 109
 None
 1.13A 3jq7C-2chrA:
undetectable		 3jq7C-2chrA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 SER A 171
TYR B 176
VAL A 103
LEU A  88
 None
 0.96A 3jq7C-2dppA:
undetectable		 3jq7C-2dppA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASP A 548
VAL A 570
LEU A 572
PRO A 573
 None
 0.96A 3jq7C-2g3nA:
undetectable		 3jq7C-2g3nA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h36 HYPOTHETICAL PROTEIN
SIFV0014

(Sulfolobus
islandicus
filamentous
virus) 		PF07118
(DUF1374) 		4 PHE X  30
TYR X  85
VAL X 103
LEU X  22
 None
 1.02A 3jq7C-2h36X:
undetectable		 3jq7C-2h36X:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		4 SER A  38
TYR A  20
VAL A  53
LEU A  15
 None
 1.03A 3jq7C-2ie8A:
5.5		 3jq7C-2ie8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le9 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
PROTEIN S100-A13

(Homo sapiens) 		PF01023
(S_100)
PF13895
(Ig_2) 		4 ARG B  29
VAL A  46
LEU A  48
PRO A  49
 None
 0.99A 3jq7C-2le9B:
undetectable		 3jq7C-2le9B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)

(Homo sapiens) 		PF01583
(APS_kinase) 		4 SER A 133
PHE A 131
VAL A 116
LEU A  95
 None
ADX  A 400 (-4.7A)
None
None
 0.98A 3jq7C-2peyA:
5.2		 3jq7C-2peyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 SER A 710
PHE A 708
VAL A 685
LEU A 704
 None
 1.12A 3jq7C-2pziA:
undetectable		 3jq7C-2pziA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		6 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.52A 3jq7C-2qhxA:
40.1		 3jq7C-2qhxA:
49.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		4 SER A 244
VAL A 256
LEU A 258
PRO A 259
 None
 1.11A 3jq7C-2r3bA:
7.2		 3jq7C-2r3bA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 ARG A 317
SER A 326
ASP A 252
VAL A 256
 13P  A1968 ( 3.6A)
None
None
13P  A1968 ( 4.5A)
 1.14A 3jq7C-2r4jA:
5.3		 3jq7C-2r4jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		4 SER A 352
ASP A 442
VAL A 568
LEU A 566
 None
 1.15A 3jq7C-2rkcA:
undetectable		 3jq7C-2rkcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 4 PHE 1 192
TYR 1 160
VAL 1 169
PRO 1  59
 None
 0.93A 3jq7C-2ws91:
undetectable		 3jq7C-2ws91:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsi FAD SYNTHETASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 SER A 204
PHE A 205
TYR A  17
LEU A  69
 None
 1.09A 3jq7C-2wsiA:
undetectable		 3jq7C-2wsiA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ARG A 160
SER A 210
ASP A  47
VAL A  69
 None
 1.15A 3jq7C-2yxzA:
undetectable		 3jq7C-2yxzA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606

(Thermus
thermophilus) 		PF01784
(NIF3) 		4 ARG A 201
VAL A 194
LEU A 177
PRO A 178
 None
 1.11A 3jq7C-2yybA:
undetectable		 3jq7C-2yybA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 SER A 260
PHE A 261
ASP A 202
LEU A 282
 None
None
None
NGA  A   2 (-4.8A)
 1.06A 3jq7C-2z8eA:
undetectable		 3jq7C-2z8eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztt RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		PF00602
(Flu_PB1) 		4 SER A 704
PHE A 700
ASP A 725
LEU A 695
 None
 1.13A 3jq7C-2zttA:
undetectable		 3jq7C-2zttA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyi LIPASE, PUTATIVE

(Archaeoglobus
fulgidus) 		PF00561
(Abhydrolase_1) 		4 SER A 309
TYR A 313
VAL A 338
LEU A 336
 None
 1.00A 3jq7C-2zyiA:
4.5		 3jq7C-2zyiA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		4 PHE A 324
ASP A 111
TYR A   7
LEU A 227
 None
None
EDO  A 357 ( 4.5A)
None
 0.88A 3jq7C-3alfA:
3.5		 3jq7C-3alfA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		4 SER A 352
ASP A 442
VAL A 568
LEU A 566
 None
 1.07A 3jq7C-3alxA:
undetectable		 3jq7C-3alxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		4 PHE A 102
ASP A 226
TYR A 173
LEU A  68
 None
 0.85A 3jq7C-3b4yA:
undetectable		 3jq7C-3b4yA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPI
PSEUDOPILIN GSPK

(Escherichia
coli) 		PF02501
(T2SSI)
PF03934
(T2SSK) 		4 SER K  49
PHE I 112
TYR I  52
LEU I  81
 None
 0.65A 3jq7C-3ci0K:
undetectable		 3jq7C-3ci0K:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr7 ADENYLYL-SULFATE
KINASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase) 		4 SER A 107
PHE A 105
VAL A  90
LEU A  69
 PPS  A2002 (-4.9A)
PPS  A2002 (-4.6A)
None
None
 1.11A 3jq7C-3cr7A:
2.2		 3jq7C-3cr7A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		4 TYR A 291
VAL A 250
LEU A 148
PRO A 149
 None
 1.05A 3jq7C-3dcdA:
undetectable		 3jq7C-3dcdA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb2 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		4 TYR A 221
VAL A  74
LEU A  42
PRO A  10
 None
 1.12A 3jq7C-3eb2A:
undetectable		 3jq7C-3eb2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 SER A 717
ASP A 612
LEU A  78
PRO A  79
 None
 1.07A 3jq7C-3eh2A:
3.5		 3jq7C-3eh2A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Bos taurus) 		PF06052
(3-HAO) 		4 SER A 219
TYR A 262
VAL A 275
LEU A 273
 None
 1.07A 3jq7C-3fe5A:
undetectable		 3jq7C-3fe5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgv UNCHARACTERIZED
PROTEIN WITH
FERREDOXIN-LIKE FOLD

(Ruegeria
pomeroyi) 		PF03992
(ABM) 		4 ARG A  42
TYR A  76
VAL A  34
LEU A  52
 EDO  A 106 ( 3.2A)
None
None
EDO  A 106 ( 4.4A)
 1.03A 3jq7C-3fgvA:
undetectable		 3jq7C-3fgvA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		4 SER A 452
ASP A 457
VAL A 460
LEU A 521
 None
 1.03A 3jq7C-3fhaA:
undetectable		 3jq7C-3fhaA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		4 SER A 203
PHE A 204
TYR A  17
LEU A  70
 None
 1.08A 3jq7C-3g5aA:
undetectable		 3jq7C-3g5aA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 ARG A  55
ASP A 111
VAL A  29
LEU A  21
 None
 1.07A 3jq7C-3gs6A:
2.4		 3jq7C-3gs6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ARG C 327
VAL C 203
LEU C 355
PRO C 356
 None
 1.06A 3jq7C-3gzdC:
3.2		 3jq7C-3gzdC:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 TYR A  98
VAL A 263
LEU A 109
PRO A 114
 None
 1.00A 3jq7C-3hvnA:
undetectable		 3jq7C-3hvnA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
horikoshii) 		PF07969
(Amidohydro_3) 		4 ASP X 326
TYR X 250
VAL X 372
LEU X 374
 None
 1.05A 3jq7C-3ighX:
2.5		 3jq7C-3ighX:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itq PROLYL
4-HYDROXYLASE, ALPHA
SUBUNIT DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13640
(2OG-FeII_Oxy_3) 		4 PHE A 161
VAL A  42
LEU A  40
PRO A  39
 None
 1.16A 3jq7C-3itqA:
undetectable		 3jq7C-3itqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE

(Yersinia pestis) 		PF00731
(AIRC) 		4 SER A 108
ASP A  24
VAL A  18
LEU A  85
 None
 1.14A 3jq7C-3kuuA:
2.9		 3jq7C-3kuuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		4 PHE A 157
VAL A 134
LEU A 176
PRO A 155
 None
 1.03A 3jq7C-3l7oA:
2.4		 3jq7C-3l7oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		4 ASP A 239
VAL A 196
LEU A 243
PRO A 219
 None
 1.05A 3jq7C-3lm3A:
undetectable		 3jq7C-3lm3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A1189
ASP A1135
VAL A1176
LEU A1184
 CCX  A   1 ( 4.4A)
None
None
None
 1.10A 3jq7C-3lw0A:
undetectable		 3jq7C-3lw0A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		4 SER A 127
PHE A 124
VAL A 112
LEU A 114
 None
 1.05A 3jq7C-3n11A:
undetectable		 3jq7C-3n11A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n91 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735) 		4 ARG A 331
SER A 290
LEU A  48
PRO A 198
 None
 1.01A 3jq7C-3n91A:
undetectable		 3jq7C-3n91A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkj VILLIN-1

(Gallus gallus) 		PF02209
(VHP) 		4 ARG A  55
PHE A  58
VAL A  50
LEU A  42
 None
 1.11A 3jq7C-3nkjA:
undetectable		 3jq7C-3nkjA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 ARG A  59
SER A 350
VAL A  46
LEU A  56
 None
 0.83A 3jq7C-3nksA:
4.3		 3jq7C-3nksA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odn DALLY-LIKE PROTEIN

(Drosophila
melanogaster) 		PF01153
(Glypican) 		4 PHE A 377
VAL A 388
LEU A 249
PRO A 251
 None
 1.11A 3jq7C-3odnA:
undetectable		 3jq7C-3odnA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oka GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-6)-PHOSPHAT
IDYLINOSITOL
MONOMANNOSIDE
MANNOSYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ASP A  13
VAL A  67
LEU A  69
PRO A  70
 None
None
GOL  A 801 ( 4.6A)
None
 0.74A 3jq7C-3okaA:
6.0		 3jq7C-3okaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orf DIHYDROPTERIDINE
REDUCTASE

(Dictyostelium
discoideum) 		PF00106
(adh_short) 		4 SER A  24
PHE A  22
VAL A 196
LEU A  14
 None
None
None
NAD  A 901 (-4.6A)
 1.05A 3jq7C-3orfA:
20.8		 3jq7C-3orfA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASP A 544
VAL A 567
LEU A 569
PRO A 570
 None
 1.08A 3jq7C-3pocA:
undetectable		 3jq7C-3pocA:
17.27