SIMILAR PATTERNS OF AMINO ACIDS FOR 3JQ7_B_DX2B271_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 PHE A 401
ASP A 257
TYR A 269
PRO A 404
 None
 0.97A 3jq7B-1cpyA:
4.3		 3jq7B-1cpyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6b GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 ARG A  24
SER A  73
LEU A 209
PRO A 210
 None
 1.08A 3jq7B-1e6bA:
undetectable		 3jq7B-1e6bA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 PHE A 499
ASP A 518
TYR A 496
LEU A 538
 None
 1.06A 3jq7B-1gxlA:
undetectable		 3jq7B-1gxlA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 ASP A 237
LEU A 147
PRO A 148
TRP A 208
 None
 1.23A 3jq7B-1hzvA:
undetectable		 3jq7B-1hzvA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 PHE A 293
LEU A  73
PRO A  76
TRP A 220
 None
None
None
GOL  A 350 ( 4.2A)
 1.21A 3jq7B-1jyeA:
7.0		 3jq7B-1jyeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 PHE A 278
ASP A 216
TYR A 280
LEU A 247
 None
 1.17A 3jq7B-1lnlA:
undetectable		 3jq7B-1lnlA:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		6 ARG A  22
SER A 103
ASP A 169
TYR A 182
LEU A 217
PRO A 218
 NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
NDP  A1277 (-3.9A)
MTX  A1278 ( 4.7A)
None
MTX  A1278 ( 4.1A)
 0.34A 3jq7B-1mxfA:
42.9		 3jq7B-1mxfA:
56.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		7 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
PRO A 230
 NDP  A 300 ( 3.7A)
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
NDP  A 300 ( 3.7A)
MTX  A 351 ( 4.4A)
MTX  A 351 (-4.9A)
MTX  A 351 (-3.3A)
 0.46A 3jq7B-1p33A:
41.7		 3jq7B-1p33A:
48.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN

(Halothiobacillus
neapolitanus) 		PF00101
(RuBisCO_small) 		4 ARG M 108
SER M  10
LEU M  19
PRO M  20
 None
 1.10A 3jq7B-1svdM:
undetectable		 3jq7B-1svdM:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN

(Halothiobacillus
neapolitanus) 		PF00101
(RuBisCO_small) 		4 ARG M 108
SER M  10
TYR M   7
LEU M  19
 None
 1.24A 3jq7B-1svdM:
undetectable		 3jq7B-1svdM:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		4 ASP A 218
TYR A 191
LEU A  98
PRO A  97
 RET  A 255 (-4.4A)
RET  A 255 (-3.7A)
None
None
 1.25A 3jq7B-1uazA:
undetectable		 3jq7B-1uazA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		4 ARG A 322
SER A 222
LEU A 293
PRO A 294
 None
 1.01A 3jq7B-1xfiA:
2.8		 3jq7B-1xfiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 SER A 234
ASP A 215
LEU A 157
PRO A 158
 None
MG  A1001 ( 4.6A)
None
None
 1.16A 3jq7B-1zjjA:
undetectable		 3jq7B-1zjjA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		4 SER A 289
ASP A 221
LEU A 203
PRO A 204
 None
 1.14A 3jq7B-1zkdA:
4.6		 3jq7B-1zkdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		4 SER A 119
PHE A 116
LEU A  92
PRO A  88
 None
 1.24A 3jq7B-2g0tA:
5.2		 3jq7B-2g0tA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1

(Mus musculus) 		PF00498
(FHA) 		4 SER A 120
PHE A 117
TYR A 124
LEU A  88
 None
 1.05A 3jq7B-2jpeA:
undetectable		 3jq7B-2jpeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ARG A 135
SER A 169
PHE A 484
PRO A 481
 None
 1.23A 3jq7B-2oipA:
undetectable		 3jq7B-2oipA:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		6 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 ( 4.5A)
None
 0.42A 3jq7B-2qhxA:
41.2		 3jq7B-2qhxA:
49.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ARG A 462
SER A 424
PHE A 401
TYR A 422
 PGR  A1749 (-4.5A)
None
None
None
 1.13A 3jq7B-2xe4A:
4.0		 3jq7B-2xe4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 ARG A 802
SER A 484
ASP A 519
TYR A 481
 None
 1.21A 3jq7B-2xt6A:
2.9		 3jq7B-2xt6A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA

(Homo sapiens) 		PF01504
(PIP5K) 		4 SER A 205
ASP A 282
LEU A 233
PRO A 231
 None
 1.24A 3jq7B-2ybxA:
undetectable		 3jq7B-2ybxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5c PROTEIN YPL144W
UNCHARACTERIZED
PROTEIN YLR021W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		4 ARG B  43
SER B 144
TYR A  59
LEU A  27
 None
 1.26A 3jq7B-2z5cB:
undetectable		 3jq7B-2z5cB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 SER A 260
PHE A 261
ASP A 202
LEU A 282
 None
None
None
NGA  A   2 (-4.8A)
 1.08A 3jq7B-2z8eA:
undetectable		 3jq7B-2z8eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztt RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		PF00602
(Flu_PB1) 		4 SER A 704
PHE A 700
ASP A 725
LEU A 695
 None
 1.09A 3jq7B-2zttA:
undetectable		 3jq7B-2zttA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		4 PHE A 324
ASP A 111
TYR A   7
LEU A 227
 None
None
EDO  A 357 ( 4.5A)
None
 0.86A 3jq7B-3alfA:
3.8		 3jq7B-3alfA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		4 PHE A 102
ASP A 226
TYR A 173
LEU A  68
 None
 0.85A 3jq7B-3b4yA:
2.2		 3jq7B-3b4yA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8c METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		4 SER A 181
PHE A 199
ASP A 172
PRO A 149
 ALA  A 502 ( 4.5A)
ALA  A 502 (-4.0A)
ALA  A 502 (-3.9A)
None
 1.10A 3jq7B-3c8cA:
undetectable		 3jq7B-3c8cA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8w ACETOACETATE
DECARBOXYLASE ADC

(Legionella
pneumophila) 		PF06314
(ADC) 		4 ARG A 118
PHE A 107
TYR A 145
PRO A 124
 LCK  A 125 (-3.9A)
None
None
LCK  A 125 ( 3.2A)
 1.26A 3jq7B-3c8wA:
undetectable		 3jq7B-3c8wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPI
PSEUDOPILIN GSPK

(Escherichia
coli) 		PF02501
(T2SSI)
PF03934
(T2SSK) 		4 SER K  49
PHE I 112
TYR I  52
LEU I  81
 None
 0.64A 3jq7B-3ci0K:
undetectable		 3jq7B-3ci0K:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 SER A 184
PHE A 186
ASP A 309
TRP A 377
 None
 0.84A 3jq7B-3e1tA:
undetectable		 3jq7B-3e1tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 SER A 717
ASP A 612
LEU A  78
PRO A  79
 None
 1.19A 3jq7B-3eh2A:
undetectable		 3jq7B-3eh2A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
DNA POLYMERASE ALPHA
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N)
PF08996
(zf-DNA_Pol) 		4 ARG A 328
SER B1361
PHE B1363
ASP A 262
 None
 1.19A 3jq7B-3floA:
undetectable		 3jq7B-3floA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		4 SER A  45
PHE A  42
ASP A   5
PRO A 233
 None
 1.11A 3jq7B-3g7uA:
9.6		 3jq7B-3g7uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ASP A 152
LEU A 126
PRO A 158
TRP A 123
 None
 1.21A 3jq7B-3hpaA:
undetectable		 3jq7B-3hpaA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 SER A 234
PHE A 236
LEU A 187
PRO A 184
 None
 1.23A 3jq7B-3hvdA:
undetectable		 3jq7B-3hvdA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3n KELCH-LIKE PROTEIN
11

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		4 SER A 144
TYR A 215
LEU A 244
PRO A 245
 None
 1.20A 3jq7B-3i3nA:
undetectable		 3jq7B-3i3nA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 SER A 667
TYR A 288
LEU A 673
PRO A 672
 None
 1.17A 3jq7B-3jclA:
undetectable		 3jq7B-3jclA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA

(Methylobacillus
flagellatus) 		PF08886
(GshA) 		4 TYR A 214
LEU A 224
PRO A 223
TRP A  31
 None
 1.21A 3jq7B-3k1tA:
undetectable		 3jq7B-3k1tA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kif 5-BLADED
BETA-PROPELLER
LECTIN

(synthetic
construct) 		PF14517
(Tachylectin) 		4 ARG A  64
ASP A  35
TYR A  41
PRO A  54
 None
 1.25A 3jq7B-3kifA:
undetectable		 3jq7B-3kifA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 ARG A 566
ASP A 519
TYR A 496
LEU A 549
 None
 1.26A 3jq7B-3ozxA:
undetectable		 3jq7B-3ozxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9f TRYPAREDOXIN

(Leishmania
major) 		PF13905
(Thioredoxin_8) 		4 ARG A  15
SER A  69
PHE A  91
ASP A  76
 MG  A 147 (-4.4A)
None
None
None
 1.25A 3jq7B-3s9fA:
undetectable		 3jq7B-3s9fA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip APOPTOSIS 1
INHIBITOR

(Drosophila
melanogaster) 		PF00653
(BIR) 		4 PHE E  51
LEU E  56
PRO E  55
TRP E  90
 None
 0.95A 3jq7B-3sipE:
undetectable		 3jq7B-3sipE:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siq APOPTOSIS 1
INHIBITOR

(Drosophila
melanogaster) 		PF00653
(BIR) 		4 PHE A  51
LEU A  56
PRO A  55
TRP A  90
 None
 1.15A 3jq7B-3siqA:
undetectable		 3jq7B-3siqA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 SER A 234
PHE A 236
LEU A 187
PRO A 184
 None
 1.19A 3jq7B-3texA:
undetectable		 3jq7B-3texA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ARG A 392
PHE A 424
ASP A 471
TYR A 417
 None
 1.13A 3jq7B-3v4oA:
5.3		 3jq7B-3v4oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 PHE A 457
ASP A 302
TYR A 367
LEU A 406
 None
 1.25A 3jq7B-3vb9A:
undetectable		 3jq7B-3vb9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpy FHA
DOMAIN-CONTAINING
PROTEIN DDL

(Arabidopsis
thaliana) 		PF00498
(FHA) 		4 SER A 122
PHE A 119
TYR A 126
LEU A  90
 None
 1.09A 3jq7B-3vpyA:
undetectable		 3jq7B-3vpyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ARG A 181
SER A 236
ASP A 402
TYR A 233
 None
 1.25A 3jq7B-3wmeA:
undetectable		 3jq7B-3wmeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		4 PHE A 262
ASP A 218
TYR A 258
LEU A 239
 None
 1.22A 3jq7B-3wsuA:
2.1		 3jq7B-3wsuA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		4 ARG A 244
SER A   3
LEU A  49
PRO A  50
 None
 1.19A 3jq7B-3wviA:
undetectable		 3jq7B-3wviA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x37 MITOCHONDRIAL
MORPHOGENESIS
PROTEIN SLD7
ZYRO0C14696P

(Zygosaccharomyces
rouxii) 		no annotation 4 ARG A  48
ASP A 115
LEU B  53
PRO B  54
 None
 1.11A 3jq7B-3x37A:
undetectable		 3jq7B-3x37A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN
PENTON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF01686
(Adeno_Penton_B)
PF03678
(Adeno_hexon_C) 		4 SER A 629
TYR A 616
LEU M  98
PRO M  97
 None
 1.13A 3jq7B-3zifA:
undetectable		 3jq7B-3zifA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 SER A1184
PHE A1186
LEU A1144
TRP A1077
 None
 0.95A 3jq7B-4a5wA:
undetectable		 3jq7B-4a5wA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		4 PHE A 343
ASP A 416
TYR A 336
LEU A 409
 None
V1N  A1600 (-2.8A)
None
None
 0.95A 3jq7B-4b2gA:
undetectable		 3jq7B-4b2gA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1

(Saccharomyces
cerevisiae) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		4 ARG A 141
PHE A  73
LEU A 186
PRO A 187
 None
 0.90A 3jq7B-4c0hA:
undetectable		 3jq7B-4c0hA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbx ACTIN-2

(Plasmodium
berghei) 		PF00022
(Actin) 		4 SER A  14
ASP A 179
LEU A 110
PRO A 109
 ATP  A1374 (-2.6A)
None
None
None
 1.14A 3jq7B-4cbxA:
undetectable		 3jq7B-4cbxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 SER A 485
TYR A 606
LEU A 569
PRO A 568
 None
 1.24A 3jq7B-4ellA:
undetectable		 3jq7B-4ellA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk9 CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF00150
(Cellulase) 		4 PHE A 262
ASP A 218
TYR A 258
LEU A 239
 None
 1.20A 3jq7B-4fk9A:
undetectable		 3jq7B-4fk9A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		4 ARG C 219
PHE C 168
ASP C 295
LEU C 177
 SO4  C 404 (-3.5A)
None
CA  C 402 (-2.3A)
None
 1.08A 3jq7B-4fl4C:
undetectable		 3jq7B-4fl4C:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5

(Homo sapiens) 		PF04106
(APG5) 		4 PHE B 182
TYR B 175
LEU B 265
PRO B 186
 None
 1.14A 3jq7B-4gdlB:
undetectable		 3jq7B-4gdlB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpv PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
eggerthii) 		PF06321
(P_gingi_FimA) 		4 SER A 248
PHE A 230
ASP A 200
PRO A 339
 None
 0.97A 3jq7B-4gpvA:
undetectable		 3jq7B-4gpvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ARG A 392
PHE A 424
ASP A 471
TYR A 417
 ACT  A 804 ( 2.9A)
None
None
None
 1.02A 3jq7B-4i1pA:
4.3		 3jq7B-4i1pA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 SER A 433
PHE A 430
ASP A 202
TYR A 198
 None
 1.18A 3jq7B-4ifqA:
undetectable		 3jq7B-4ifqA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 4 SER B 363
PHE B 367
TYR B 261
LEU B 165
 None
 0.94A 3jq7B-4iu9B:
undetectable		 3jq7B-4iu9B:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 PHE A 332
ASP A 398
TYR A 325
LEU A 391
 None
APC  A 603 (-2.6A)
None
None
 1.09A 3jq7B-4l39A:
undetectable		 3jq7B-4l39A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 SER A 180
PHE A 182
LEU A 157
PRO A 158
 None
 1.22A 3jq7B-4ntjA:
undetectable		 3jq7B-4ntjA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		4 PHE A 182
ASP A  49
TYR A 183
LEU A  32
 None
 1.24A 3jq7B-4oetA:
undetectable		 3jq7B-4oetA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.20A 3jq7B-4ohnA:
undetectable		 3jq7B-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ASP A 617
TYR A 507
LEU A 598
PRO A 599
 None
 0.89A 3jq7B-4p72A:
undetectable		 3jq7B-4p72A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pws PROLINE-RICH 28 KDA
ANTIGEN

(Mycobacterium
tuberculosis) 		PF10738
(Lpp-LpqN) 		4 ARG A 229
SER A 244
ASP A 148
TYR A 171
 None
 1.19A 3jq7B-4pwsA:
undetectable		 3jq7B-4pwsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE

(Bacteroides
fragilis) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 PHE A 405
ASP A 450
TYR A 413
TRP A 373
 FMT  A 606 (-4.6A)
GOL  A 604 (-3.0A)
None
GOL  A 603 (-3.6A)
 0.93A 3jq7B-4pysA:
undetectable		 3jq7B-4pysA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwp CHITOSANASE

(Pseudomonas sp.
A-01) 		PF01374
(Glyco_hydro_46) 		4 PHE A 189
ASP A 136
TYR A 185
LEU A 150
 None
 1.24A 3jq7B-4qwpA:
undetectable		 3jq7B-4qwpA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 ASP A 303
TYR A 243
LEU A  15
PRO A 233
 None
 1.12A 3jq7B-4upiA:
undetectable		 3jq7B-4upiA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ASP A 301
TYR A 241
LEU A  11
PRO A 231
 None
 1.18A 3jq7B-4uplA:
undetectable		 3jq7B-4uplA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		4 PHE A 315
ASP A 112
TYR A   6
LEU A 229
 None
None
MPD  A 401 (-3.5A)
None
 0.81A 3jq7B-4uriA:
undetectable		 3jq7B-4uriA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		4 SER A 360
LEU A 182
PRO A 194
TRP A 204
 None
 1.18A 3jq7B-4v1uA:
undetectable		 3jq7B-4v1uA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 4 PHE B 386
ASP B 179
TYR B  46
LEU B 298
 None
 0.96A 3jq7B-4w5uB:
undetectable		 3jq7B-4w5uB:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wcd PTERIDINE REDUCTASE

(Trypanosoma
brucei) 		PF13561
(adh_short_C2) 		8 ARG A  14
SER A  95
PHE A  97
ASP A 161
TYR A 174
LEU A 209
PRO A 210
TRP A 221
 NAP  A 301 (-3.7A)
NAP  A 301 ( 3.1A)
3KH  A 302 (-3.5A)
NAP  A 301 ( 3.8A)
3KH  A 302 ( 4.7A)
None
3KH  A 302 ( 4.0A)
3KH  A 302 (-3.8A)
 0.62A 3jq7B-4wcdA:
45.1		 3jq7B-4wcdA:
93.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 SER A 353
TYR A  69
LEU A  80
PRO A  79
 None
 1.12A 3jq7B-4xnuA:
undetectable		 3jq7B-4xnuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1
RNL

(Capnocytophaga
gingivalis) 		PF16542
(PNKP_ligase)
no annotation 		4 SER B 142
ASP C  66
LEU C  74
PRO C  73
 None
 0.99A 3jq7B-4xruB:
undetectable		 3jq7B-4xruB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 SER A 474
TYR A 470
LEU A1445
PRO A1471
 None
 1.21A 3jq7B-4yknA:
undetectable		 3jq7B-4yknA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ARG A1453
SER A1314
LEU A1438
PRO A1439
 None
 0.94A 3jq7B-5dotA:
6.0		 3jq7B-5dotA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 SER A  91
ASP A 298
TYR A 390
LEU A 343
 None
 0.94A 3jq7B-5eb5A:
3.5		 3jq7B-5eb5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 4 ARG B 469
SER B 749
PHE B 704
TYR B 722
 None
 1.12A 3jq7B-5efnB:
5.3		 3jq7B-5efnB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evm FUSION GLYCOPROTEIN
F0

(Nipah
henipavirus) 		PF00523
(Fusion_gly) 		4 SER A 259
ASP A 252
LEU A  53
PRO A  52
 None
 1.21A 3jq7B-5evmA:
undetectable		 3jq7B-5evmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f17 NON-STRUCTURAL
PROTEIN 11

(Equine
arteritis virus) 		no annotation 4 ARG A 110
SER A 140
LEU A 151
PRO A 150
 None
 1.09A 3jq7B-5f17A:
undetectable		 3jq7B-5f17A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 104
SER A 106
ASP A 374
LEU A  93
 None
 1.17A 3jq7B-5fr8A:
undetectable		 3jq7B-5fr8A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM

(Salmonella
enterica) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		4 ARG A 294
ASP A 493
PRO A 541
TRP A 527
 None
 1.24A 3jq7B-5i5dA:
undetectable		 3jq7B-5i5dA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw C-TERMINAL PEPTIDE
OF PUTATIVE
ANGIOTENSINOGEN
PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		4 SER A 396
PHE A 107
TYR A 357
LEU C 433
 None
 1.10A 3jq7B-5inwA:
undetectable		 3jq7B-5inwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 PHE A 345
ASP A 427
TYR A 338
LEU A 420
 None
AMP  A 701 (-2.8A)
None
None
 0.95A 3jq7B-5kodA:
undetectable		 3jq7B-5kodA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 SER A 564
ASP A 590
LEU A 488
PRO A 489
 None
MG  A 702 (-2.6A)
C2E  A 701 (-4.6A)
None
 1.21A 3jq7B-5m1tA:
undetectable		 3jq7B-5m1tA:
26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		5 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.52A 3jq7B-5tgdA:
32.1		 3jq7B-5tgdA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 SER A1077
ASP A1172
LEU A1115
PRO A1114
 None
 0.82A 3jq7B-5u1sA:
undetectable		 3jq7B-5u1sA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6c HEMOLYSIN-RELATED
PROTEIN

(Vibrio cholerae) 		no annotation 4 ARG A 876
SER A 918
PHE A 850
TYR A 921
 None
None
GOL  A1001 (-4.7A)
None
 0.92A 3jq7B-5v6cA:
undetectable		 3jq7B-5v6cA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypz COFB

(Escherichia
coli) 		no annotation 4 SER A 130
PHE A 129
LEU A  71
PRO A  70
 None
 1.19A 3jq7B-5ypzA:
undetectable		 3jq7B-5ypzA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE

(Acinetobacter
baumannii) 		no annotation 4 PHE A  79
TYR A  83
LEU A  64
PRO A  65
 None
 1.10A 3jq7B-6a31A:
undetectable		 3jq7B-6a31A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11

(Homo sapiens) 		no annotation 4 SER B  26
ASP M 384
TYR B  31
LEU A  47
 None
 1.07A 3jq7B-6ba5B:
undetectable		 3jq7B-6ba5B:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 4 SER A1766
ASP A1786
LEU A1804
PRO A1794
 None
 0.99A 3jq7B-6bq1A:
undetectable		 3jq7B-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6el1 YAXB

(Yersinia
enterocolitica) 		no annotation 4 SER O  23
PHE O  19
LEU O 133
TRP O 305
 None
 1.25A 3jq7B-6el1O:
undetectable		 3jq7B-6el1O:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gmb HYDROXYACID OXIDASE
1

(Homo sapiens) 		no annotation 4 SER A 203
PHE A 175
LEU A 181
PRO A 178
 None
 1.23A 3jq7B-6gmbA:
undetectable		 3jq7B-6gmbA:
18.75