SIMILAR PATTERNS OF AMINO ACIDS FOR 3JB3_A_SAMA1102_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1anu COHESIN-2

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		3 ARG A  38
ASP A 133
ASP A 114
 None
 0.72A 3jb3A-1anuA:
0.0		 3jb3A-1anuA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		3 ARG A 308
ASP A 360
ASP A 309
 None
 0.82A 3jb3A-1c7jA:
0.0		 3jb3A-1c7jA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		3 ARG A 791
ASP A 607
ASP A 790
 None
 0.89A 3jb3A-1d5fA:
0.1		 3jb3A-1d5fA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		3 ARG A 276
ASP A  60
ASP A 273
 None
 0.72A 3jb3A-1drtA:
0.0		 3jb3A-1drtA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 ARG A 234
ASP A 113
ASP A 231
 None
 0.74A 3jb3A-1gpeA:
0.0		 3jb3A-1gpeA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		3 ARG A 128
ASP A 130
ASP A 100
 None
 0.93A 3jb3A-1gq8A:
0.0		 3jb3A-1gq8A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Weissella
confusa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A 315
ASP A 323
ASP A 316
 None
 0.90A 3jb3A-1hyhA:
0.0		 3jb3A-1hyhA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE

(Pyrococcus
furiosus) 		PF13476
(AAA_23) 		3 ARG A   5
ASP A  16
ASP A  72
 None
 0.81A 3jb3A-1ii8A:
0.0		 3jb3A-1ii8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 ARG A 334
ASP A 348
ASP A 331
 None
 0.93A 3jb3A-1nneA:
2.0		 3jb3A-1nneA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p27 MAGO NASHI PROTEIN
HOMOLOG

(Homo sapiens) 		PF02792
(Mago_nashi) 		3 ARG A  27
ASP A   4
ASP A  29
 None
 0.69A 3jb3A-1p27A:
undetectable		 3jb3A-1p27A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		3 ARG A 408
ASP A 412
ASP A 406
 None
 0.74A 3jb3A-1rdrA:
undetectable		 3jb3A-1rdrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 ARG A 165
ASP A 124
ASP A 200
 None
CA  A 902 (-2.1A)
None
 0.83A 3jb3A-1su3A:
undetectable		 3jb3A-1su3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq5 PROTEIN YHHW

(Escherichia
coli) 		PF02678
(Pirin) 		3 ARG A 150
ASP A 159
ASP A 148
 None
 0.92A 3jb3A-1tq5A:
undetectable		 3jb3A-1tq5A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w89 THIOREDOXIN

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 ARG A  14
ASP A   7
ASP A  13
 None
 0.74A 3jb3A-1w89A:
undetectable		 3jb3A-1w89A:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 ARG A 211
ASP A 238
ASP A 213
 None
 0.90A 3jb3A-1zjjA:
undetectable		 3jb3A-1zjjA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		3 ARG A 185
ASP A 164
ASP A 187
 None
 0.89A 3jb3A-2af5A:
undetectable		 3jb3A-2af5A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		3 ARG A 189
ASP A 184
ASP A 188
 None
 0.94A 3jb3A-2d7iA:
undetectable		 3jb3A-2d7iA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di8 FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		3 ARG A  12
ASP A  38
ASP A  10
 None
 0.92A 3jb3A-2di8A:
undetectable		 3jb3A-2di8A:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp3 CASPASE NC

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		3 ARG A 212
ASP A 208
ASP A 205
 None
 0.94A 3jb3A-2fp3A:
1.5		 3jb3A-2fp3A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gi7 GPVI PROTEIN

(Homo sapiens) 		PF13895
(Ig_2) 		3 ARG A 166
ASP A 121
ASP A 167
 None
 0.85A 3jb3A-2gi7A:
undetectable		 3jb3A-2gi7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		3 ARG A 680
ASP A 670
ASP A 614
 None
 0.85A 3jb3A-2gq3A:
0.5		 3jb3A-2gq3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 180
ASP A 182
ASP A 179
 None
 0.71A 3jb3A-2hdiA:
undetectable		 3jb3A-2hdiA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		3 ARG A  88
ASP A  63
ASP A  87
 None
 0.90A 3jb3A-2nwhA:
undetectable		 3jb3A-2nwhA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poi BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00653
(BIR) 		3 ARG A  72
ASP A  77
ASP A  71
 None
 0.86A 3jb3A-2poiA:
undetectable		 3jb3A-2poiA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ARG A 163
ASP A 109
ASP A 105
 None
 0.87A 3jb3A-2q50A:
3.2		 3jb3A-2q50A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0h CGL3 LECTIN

(Coprinopsis
cinerea) 		PF00337
(Gal-bind_lectin) 		3 ARG A 109
ASP A 105
ASP A 108
 None
 0.90A 3jb3A-2r0hA:
undetectable		 3jb3A-2r0hA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		3 ARG A 255
ASP A 261
ASP A 248
 None
 0.62A 3jb3A-2rgjA:
undetectable		 3jb3A-2rgjA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		3 ARG A 167
ASP A 135
ASP A 163
 None
 0.85A 3jb3A-2x8uA:
undetectable		 3jb3A-2x8uA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		3 ARG A  95
ASP A 366
ASP A 363
 None
 0.81A 3jb3A-2yjnA:
undetectable		 3jb3A-2yjnA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		3 ARG A 525
ASP A 459
ASP A 529
 None
 0.90A 3jb3A-2ylzA:
undetectable		 3jb3A-2ylzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus musculus) 		PF00640
(PID)
PF10515
(APP_amyloid) 		3 ARG A  76
ASP A  81
ASP A  75
 None
 0.71A 3jb3A-2yt0A:
undetectable		 3jb3A-2yt0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 ARG A  38
ASP A 131
ASP A  36
 None
 0.86A 3jb3A-3d1jA:
undetectable		 3jb3A-3d1jA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3r HYDROGENASE ASSEMBLY
CHAPERONE HYPC/HUPF

(Shewanella
oneidensis) 		PF01455
(HupF_HypC) 		3 ARG A  16
ASP A  29
ASP A  13
 None
 0.70A 3jb3A-3d3rA:
undetectable		 3jb3A-3d3rA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlj BETA-ALA-HIS
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 ARG A 342
ASP A 233
ASP A 231
 None
None
UNX  A2010 ( 4.8A)
 0.69A 3jb3A-3dljA:
undetectable		 3jb3A-3dljA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eex OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		3 ARG A 208
ASP A 187
ASP A 210
 None
 0.84A 3jb3A-3eexA:
undetectable		 3jb3A-3eexA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		3 ARG A 254
ASP A 232
ASP A 295
 None
 0.84A 3jb3A-3if9A:
undetectable		 3jb3A-3if9A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 ARG A 350
ASP A 364
ASP A 347
 None
 0.83A 3jb3A-3k0sA:
2.7		 3jb3A-3k0sA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		3 ARG A 239
ASP A 315
ASP A 241
 NAG  A 502 ( 2.7A)
None
None
 0.63A 3jb3A-3nv3A:
undetectable		 3jb3A-3nv3A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L15P

(Haloarcula
marismortui) 		PF00828
(Ribosomal_L27A) 		3 ARG K  90
ASP K  95
ASP K  80
 None
 0.94A 3jb3A-3ow2K:
undetectable		 3jb3A-3ow2K:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owu STEROID
DELTA-ISOMERASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		3 ARG A 112
ASP A  35
ASP A 108
 None
 0.92A 3jb3A-3owuA:
undetectable		 3jb3A-3owuA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 ARG A  41
ASP A  37
ASP A 287
 None
 0.87A 3jb3A-3rv2A:
undetectable		 3jb3A-3rv2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		3 ARG A 148
ASP A 254
ASP A  99
 None
 0.87A 3jb3A-3tscA:
3.5		 3jb3A-3tscA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 RAS-RELATED PROTEIN
RAB-35

(Homo sapiens) 		PF00071
(Ras) 		3 ARG B 127
ASP B  89
ASP B 124
 None
 0.85A 3jb3A-3tw8B:
2.3		 3jb3A-3tw8B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 ARG A 150
ASP A  36
ASP A  44
 None
 0.84A 3jb3A-3ufbA:
5.9		 3jb3A-3ufbA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A  26
ASP A 182
ASP A 177
 None
 0.94A 3jb3A-3ugvA:
undetectable		 3jb3A-3ugvA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		3 ARG A 328
ASP A 137
ASP A 326
 None
 0.88A 3jb3A-3vb9A:
undetectable		 3jb3A-3vb9A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		3 ARG A 190
ASP A 159
ASP A 186
 None
 0.79A 3jb3A-3vohA:
1.4		 3jb3A-3vohA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		3 ARG A 628
ASP A 486
ASP A 631
 None
 0.92A 3jb3A-3vtaA:
undetectable		 3jb3A-3vtaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1

(Mus musculus) 		PF00459
(Inositol_P) 		3 ARG A 248
ASP A 244
ASP A 274
 None
 0.93A 3jb3A-4as5A:
undetectable		 3jb3A-4as5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ARG A1295
ASP A1298
ASP A1268
 None
 0.81A 3jb3A-4c3hA:
undetectable		 3jb3A-4c3hA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN

(Arabidopsis
thaliana) 		PF00225
(Kinesin) 		3 ARG A1007
ASP A 960
ASP A1004
 None
 0.91A 3jb3A-4frzA:
undetectable		 3jb3A-4frzA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00012
(HSP70) 		3 ARG A 126
ASP A 151
ASP A 130
 None
 0.75A 3jb3A-4kboA:
undetectable		 3jb3A-4kboA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 ARG A 315
ASP A 323
ASP A 316
 None
 0.91A 3jb3A-4lq1A:
undetectable		 3jb3A-4lq1A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okj 3'-5'
EXORIBONUCLEASE
RV2179C/MT2234.1

(Mycobacterium
tuberculosis) 		PF16473
(DUF5051) 		3 ARG A 152
ASP A   6
ASP A 148
 None
MG  A 202 (-3.1A)
None
 0.91A 3jb3A-4okjA:
undetectable		 3jb3A-4okjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		3 ARG A 402
ASP A 419
ASP A 422
 None
 0.73A 3jb3A-4ow2A:
undetectable		 3jb3A-4ow2A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP

(Homo sapiens) 		PF00653
(BIR) 		3 ARG A  72
ASP A  77
ASP A  71
 None
 0.87A 3jb3A-4oxcA:
undetectable		 3jb3A-4oxcA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		3 ARG A 369
ASP A 317
ASP A 368
 None
 0.71A 3jb3A-4ozyA:
undetectable		 3jb3A-4ozyA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE

(Caldicellulosiruptor
bescii) 		PF00331
(Glyco_hydro_10) 		3 ARG A 259
ASP A 316
ASP A 257
 None
 0.62A 3jb3A-4pmdA:
undetectable		 3jb3A-4pmdA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfp ACIDIC PHOSPHOLIPASE
A2 5

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		3 ARG A  97
ASP A 101
ASP A  98
 None
 0.75A 3jb3A-4rfpA:
undetectable		 3jb3A-4rfpA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		3 ARG A1367
ASP A1379
ASP A1365
 None
 0.83A 3jb3A-4u48A:
undetectable		 3jb3A-4u48A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		3 ARG A 183
ASP A 174
ASP A 153
 None
 0.81A 3jb3A-4wgxA:
undetectable		 3jb3A-4wgxA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhb IRON-CHELATOR
UTILIZATION PROTEIN

(Thermobifida
fusca) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		3 ARG A  92
ASP A  36
ASP A 104
 None
 0.77A 3jb3A-4yhbA:
undetectable		 3jb3A-4yhbA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 ARG A 310
ASP A 512
ASP A 332
 NAG  A 704 (-3.4A)
None
None
 0.90A 3jb3A-4z61A:
undetectable		 3jb3A-4z61A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		3 ARG A 476
ASP A 479
ASP A 473
 None
 0.87A 3jb3A-5a5tA:
undetectable		 3jb3A-5a5tA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb7 OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 3 ARG A 170
ASP A 195
ASP A 171
 None
 0.66A 3jb3A-5cb7A:
undetectable		 3jb3A-5cb7A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 ARG A 314
ASP A 319
ASP A  35
 None
 0.69A 3jb3A-5ce9A:
undetectable		 3jb3A-5ce9A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgz 4-OXALMESACONATE
HYDRATASE

(Pseudomonas
putida) 		PF02585
(PIG-L) 		3 ARG A  46
ASP A  86
ASP A  89
 None
GOL  A 308 (-3.3A)
None
 0.90A 3jb3A-5cgzA:
undetectable		 3jb3A-5cgzA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4w PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A 823
ASP A 820
ASP A 822
 None
 0.85A 3jb3A-5d4wA:
undetectable		 3jb3A-5d4wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dan 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		3 ARG A 151
ASP A 168
ASP A 182
 None
 0.75A 3jb3A-5danA:
undetectable		 3jb3A-5danA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dux GALECTIN-4

(Homo sapiens) 		no annotation 3 ARG B  67
ASP B 141
ASP B  69
 LAT  B 201 (-2.6A)
None
None
 0.67A 3jb3A-5duxB:
undetectable		 3jb3A-5duxB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 ARG C  16
ASP C 175
ASP C  48
 None
 0.89A 3jb3A-5dwzC:
undetectable		 3jb3A-5dwzC:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		3 ARG A 129
ASP A 122
ASP A 179
 None
 0.73A 3jb3A-5gggA:
undetectable		 3jb3A-5gggA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggk PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF15711
(ILEI) 		3 ARG A 129
ASP A 122
ASP A 179
 EDO  A 305 ( 3.6A)
None
MBE  A 301 ( 3.0A)
 0.58A 3jb3A-5ggkA:
undetectable		 3jb3A-5ggkA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF00270
(DEAD) 		3 ARG A 135
ASP A 169
ASP A 138
 None
 0.87A 3jb3A-5gjuA:
undetectable		 3jb3A-5gjuA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 ARG A 594
ASP A 597
ASP A 572
 None
 0.74A 3jb3A-5hqbA:
undetectable		 3jb3A-5hqbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iay E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF12148
(TTD) 		3 ARG A 207
ASP A 190
ASP A 142
 None
 0.74A 3jb3A-5iayA:
undetectable		 3jb3A-5iayA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		3 ARG A 283
ASP A 231
ASP A 280
 None
 0.85A 3jb3A-5jheA:
undetectable		 3jb3A-5jheA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 ARG A  90
ASP A 115
ASP A  91
 None
 0.90A 3jb3A-5k3jA:
undetectable		 3jb3A-5k3jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 ARG A 177
ASP A 215
ASP A 174
 None
 0.79A 3jb3A-5kznA:
undetectable		 3jb3A-5kznA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		3 ARG A 637
ASP A 653
ASP A 636
 None
 0.71A 3jb3A-5mqmA:
undetectable		 3jb3A-5mqmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		3 ARG A1841
ASP A1849
ASP A1842
 None
GOL  A2049 ( 4.6A)
None
 0.79A 3jb3A-5mznA:
undetectable		 3jb3A-5mznA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 ARG A 174
ASP A 177
ASP A 142
 None
 0.87A 3jb3A-5olsA:
undetectable		 3jb3A-5olsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 3 ARG B  55
ASP B 135
ASP B  56
 None
 0.92A 3jb3A-5op0B:
undetectable		 3jb3A-5op0B:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 3 ARG A 425
ASP A 381
ASP A 373
 None
 0.79A 3jb3A-5oydA:
undetectable		 3jb3A-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		3 ARG A 481
ASP A 460
ASP A 484
 None
 0.84A 3jb3A-5ttdA:
undetectable		 3jb3A-5ttdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		3 ARG E 634
ASP E 636
ASP E 577
 None
 0.88A 3jb3A-5u8sE:
undetectable		 3jb3A-5u8sE:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 3 ARG A 454
ASP A 405
ASP A 452
 None
 0.93A 3jb3A-5v2dA:
undetectable		 3jb3A-5v2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6a ENDOGLUCANASE,
PUTATIVE

(Aspergillus
fumigatus) 		no annotation 3 ARG A  58
ASP A  45
ASP A  53
 None
 0.50A 3jb3A-5x6aA:
undetectable		 3jb3A-5x6aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 3 ARG A 346
ASP A 360
ASP A 343
 None
 0.89A 3jb3A-5x9wA:
undetectable		 3jb3A-5x9wA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk2 DIACYLGLYCEROL
LIPASE

(Aspergillus
oryzae) 		no annotation 3 ARG A 128
ASP A 136
ASP A 129
 None
 0.92A 3jb3A-5xk2A:
undetectable		 3jb3A-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xox TRNA(HIS)
GUANYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF04446
(Thg1)
PF14413
(Thg1C) 		3 ARG A 133
ASP A  77
ASP A 131
 None
GTP  A 301 (-2.4A)
None
 0.64A 3jb3A-5xoxA:
undetectable		 3jb3A-5xoxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyf TERF1-INTERACTING
NUCLEAR FACTOR 2

(Homo sapiens) 		no annotation 3 ARG A  52
ASP A  96
ASP A 103
 None
 0.84A 3jb3A-5xyfA:
undetectable		 3jb3A-5xyfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3x BETA-XYLANASE

(Caldicellulosiruptor
owensensis) 		no annotation 3 ARG A 259
ASP A 316
ASP A 257
 None
 0.64A 3jb3A-5y3xA:
undetectable		 3jb3A-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 3 ARG A 120
ASP A  70
ASP A  65
 None
 0.88A 3jb3A-6brsA:
undetectable		 3jb3A-6brsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1q SOLUBLE CYTOCHROME
B562, C5A
ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 3 ARG B 284
ASP B 277
ASP B 281
 None
 0.87A 3jb3A-6c1qB:
undetectable		 3jb3A-6c1qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 3 ARG L 201
ASP L 263
ASP L 202
 None
 0.84A 3jb3A-6cfwL:
undetectable		 3jb3A-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4g PROBABLE U2 SMALL
NUCLEAR
RIBONUCLEOPROTEIN A'

(Drosophila
melanogaster) 		no annotation 3 ARG A  22
ASP A  42
ASP A  45
 None
 0.90A 3jb3A-6f4gA:
undetectable		 3jb3A-6f4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzv PROCOLLAGEN
C-ENDOPEPTIDASE
ENHANCER 1

(Homo sapiens) 		no annotation 3 ARG D 189
ASP D 233
ASP D 185
 None
CA  D 302 (-3.1A)
None
 0.86A 3jb3A-6fzvD:
undetectable		 3jb3A-6fzvD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		3 ARG B  51
ASP H  51
ASP B  94
 None
 0.79A 3jb3A-6g72B:
undetectable		 3jb3A-6g72B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 3 ARG A 600
ASP A 620
ASP A 623
 None
 0.88A 3jb3A-6g9oA:
undetectable		 3jb3A-6g9oA:
undetectable