SIMILAR PATTERNS OF AMINO ACIDS FOR 3JB2_A_SAMA1102_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1anu COHESIN-2

(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
3 ARG A  38
ASP A 133
ASP A 114
None
0.72A 3jb2A-1anuA:
0.0
3jb2A-1anuA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN


(Cricetulus
griseus)
PF00004
(AAA)
3 ARG A 615
ASP A 579
ASP A 612
None
None
ANP  A   1 ( 4.3A)
0.91A 3jb2A-1d2nA:
0.0
3jb2A-1d2nA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE


(Homo sapiens)
PF00632
(HECT)
3 ARG A 791
ASP A 607
ASP A 790
None
0.91A 3jb2A-1d5fA:
0.1
3jb2A-1d5fA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)


(Penicillium
amagasakiense)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
3 ARG A 234
ASP A 113
ASP A 231
None
0.72A 3jb2A-1gpeA:
0.0
3jb2A-1gpeA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE


(Weissella
confusa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
3 ARG A 315
ASP A 323
ASP A 316
None
0.84A 3jb2A-1hyhA:
0.0
3jb2A-1hyhA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A
SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN B


(Thermobifida
fusca;
Thermobifida
fusca)
PF00079
(Serpin)
no annotation
3 ARG A 306
ASP B 363
ASP A 308
None
0.90A 3jb2A-1mtpA:
0.0
3jb2A-1mtpA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS


(Thermus
aquaticus)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
3 ARG A 334
ASP A 348
ASP A 331
None
0.93A 3jb2A-1nneA:
3.7
3jb2A-1nneA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF


(Escherichia
coli)
PF00248
(Aldo_ket_red)
3 ARG A 103
ASP A 135
ASP A 141
None
0.85A 3jb2A-1og6A:
0.0
3jb2A-1og6A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE


(Escherichia
coli)
PF04055
(Radical_SAM)
PF06969
(HemN_C)
3 ARG A  47
ASP A 320
ASP A 334
None
0.86A 3jb2A-1oltA:
undetectable
3jb2A-1oltA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT


(Bean pod mottle
virus)
PF02247
(Como_LCP)
3 ARG 2  57
ASP 2  61
ASP 2  22
None
0.82A 3jb2A-1pgw2:
undetectable
3jb2A-1pgw2:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)


(Escherichia
coli)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 ARG A 521
ASP A 259
ASP A 525
None
0.93A 3jb2A-1qf7A:
undetectable
3jb2A-1qf7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE


(Enterovirus C)
PF00680
(RdRP_1)
3 ARG A 408
ASP A 412
ASP A 406
None
0.78A 3jb2A-1rdrA:
undetectable
3jb2A-1rdrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE


(Homo sapiens)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1)
3 ARG A 165
ASP A 124
ASP A 200
None
CA  A 902 (-2.1A)
None
0.82A 3jb2A-1su3A:
undetectable
3jb2A-1su3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS


(Borreliella
burgdorferi)
PF00820
(Lipoprotein_1)
3 ARG A 185
ASP A 164
ASP A 187
None
0.86A 3jb2A-2af5A:
undetectable
3jb2A-2af5A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL PROTEIN
YHEL


(Escherichia
coli)
PF04077
(DsrH)
3 ARG C  48
ASP C  39
ASP C  73
None
0.46A 3jb2A-2d1pC:
undetectable
3jb2A-2d1pC:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10


(Homo sapiens)
PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin)
3 ARG A 189
ASP A 184
ASP A 188
None
0.93A 3jb2A-2d7iA:
2.1
3jb2A-2d7iA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di8 FILAMIN-B

(Homo sapiens)
PF00630
(Filamin)
3 ARG A  12
ASP A  38
ASP A  10
None
0.93A 3jb2A-2di8A:
undetectable
3jb2A-2di8A:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
3 ARG A  81
ASP A 164
ASP A 242
None
0.90A 3jb2A-2dpnA:
undetectable
3jb2A-2dpnA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE


(Thermus
thermophilus)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
3 ARG A 110
ASP A 117
ASP A  84
None
0.93A 3jb2A-2e9fA:
2.1
3jb2A-2e9fA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gi7 GPVI PROTEIN

(Homo sapiens)
PF13895
(Ig_2)
3 ARG A 166
ASP A 121
ASP A 167
None
0.82A 3jb2A-2gi7A:
undetectable
3jb2A-2gi7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 ARG A 180
ASP A 182
ASP A 179
None
0.76A 3jb2A-2hdiA:
undetectable
3jb2A-2hdiA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]


(Aquifex
aeolicus)
PF13561
(adh_short_C2)
3 ARG A 152
ASP A 250
ASP A 101
None
0.87A 3jb2A-2p91A:
3.6
3jb2A-2p91A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poi BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 4


(Homo sapiens)
PF00653
(BIR)
3 ARG A  72
ASP A  77
ASP A  71
None
0.79A 3jb2A-2poiA:
undetectable
3jb2A-2poiA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poi BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 4


(Homo sapiens)
PF00653
(BIR)
3 ARG A  82
ASP A  59
ASP A  77
None
0.92A 3jb2A-2poiA:
undetectable
3jb2A-2poiA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0h CGL3 LECTIN

(Coprinopsis
cinerea)
PF00337
(Gal-bind_lectin)
3 ARG A 109
ASP A 105
ASP A 108
None
0.89A 3jb2A-2r0hA:
undetectable
3jb2A-2r0hA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE


(Pseudomonas
aeruginosa)
PF01494
(FAD_binding_3)
3 ARG A 255
ASP A 261
ASP A 248
None
0.69A 3jb2A-2rgjA:
undetectable
3jb2A-2rgjA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE


(Sphingomonas
wittichii)
PF00155
(Aminotran_1_2)
3 ARG A 167
ASP A 135
ASP A 163
None
0.90A 3jb2A-2x8uA:
undetectable
3jb2A-2x8uA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2


(Mus musculus)
PF00640
(PID)
PF10515
(APP_amyloid)
3 ARG A  76
ASP A  81
ASP A  75
None
0.64A 3jb2A-2yt0A:
undetectable
3jb2A-2yt0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE


(Cellulomonas
gilvus)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
3 ARG A   2
ASP A 701
ASP A 698
None
0.89A 3jb2A-3actA:
undetectable
3jb2A-3actA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF04051
(TRAPP)
3 ARG B 272
ASP B 206
ASP B 276
None
0.94A 3jb2A-3cueB:
undetectable
3jb2A-3cueB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3r HYDROGENASE ASSEMBLY
CHAPERONE HYPC/HUPF


(Shewanella
oneidensis)
PF01455
(HupF_HypC)
3 ARG A  16
ASP A  29
ASP A  13
None
0.66A 3jb2A-3d3rA:
undetectable
3jb2A-3d3rA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlj BETA-ALA-HIS
DIPEPTIDASE


(Homo sapiens)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 ARG A 342
ASP A 233
ASP A 231
None
None
UNX  A2010 ( 4.8A)
0.66A 3jb2A-3dljA:
undetectable
3jb2A-3dljA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eex OUTER SURFACE
PROTEIN A


(Borreliella
burgdorferi)
PF00820
(Lipoprotein_1)
3 ARG A 208
ASP A 187
ASP A 210
None
0.80A 3jb2A-3eexA:
undetectable
3jb2A-3eexA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2u RAVER-1

(Homo sapiens)
PF00076
(RRM_1)
3 ARG B 227
ASP B 283
ASP B 226
None
0.87A 3jb2A-3h2uB:
undetectable
3jb2A-3h2uB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis)
PF01266
(DAO)
3 ARG A 254
ASP A 232
ASP A 295
None
0.89A 3jb2A-3if9A:
2.1
3jb2A-3if9A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS


(Escherichia
coli)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
3 ARG A 350
ASP A 364
ASP A 347
None
0.83A 3jb2A-3k0sA:
undetectable
3jb2A-3k0sA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klq PUTATIVE PILUS
ANCHORING PROTEIN


(Streptococcus
pyogenes)
PF12892
(FctA)
3 ARG A 104
ASP A  83
ASP A 107
None
0.88A 3jb2A-3klqA:
undetectable
3jb2A-3klqA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis)
no annotation 3 ARG A 185
ASP A 207
ASP A 167
None
None
MG  A 326 (-2.4A)
0.92A 3jb2A-3p4gA:
undetectable
3jb2A-3p4gA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjp PUTATIVE
UNCHARACTERIZED
PROTEIN PH0350


(Pyrococcus
horikoshii)
PF01881
(Cas_Cas6)
3 ARG A 201
ASP A 153
ASP A 148
A  R  10 ( 3.4A)
None
A  R  10 ( 4.0A)
0.93A 3jb2A-3qjpA:
undetectable
3jb2A-3qjpA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE


(Mycobacterium
marinum)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
3 ARG A  41
ASP A  37
ASP A 287
None
0.92A 3jb2A-3rv2A:
undetectable
3jb2A-3rv2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus)
PF00294
(PfkB)
3 ARG A 263
ASP A 269
ASP A 273
None
0.91A 3jb2A-3ry7A:
2.4
3jb2A-3ry7A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
3 ARG A 148
ASP A 254
ASP A  99
None
0.75A 3jb2A-3tscA:
3.0
3jb2A-3tscA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 RAS-RELATED PROTEIN
RAB-35


(Homo sapiens)
PF00071
(Ras)
3 ARG B 127
ASP B  89
ASP B 124
None
0.78A 3jb2A-3tw8B:
undetectable
3jb2A-3tw8B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT


(Vibrio
vulnificus)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
3 ARG A 150
ASP A  36
ASP A  44
None
0.75A 3jb2A-3ufbA:
7.2
3jb2A-3ufbA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ARG A  26
ASP A 182
ASP A 177
None
0.91A 3jb2A-3ugvA:
undetectable
3jb2A-3ugvA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulx STRESS-INDUCED
TRANSCRIPTION FACTOR
NAC1


(Oryza sativa)
PF02365
(NAM)
3 ARG A  76
ASP A 157
ASP A  77
None
0.85A 3jb2A-3ulxA:
undetectable
3jb2A-3ulxA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea)
PF01341
(Glyco_hydro_6)
3 ARG A 190
ASP A 159
ASP A 186
None
0.91A 3jb2A-3vohA:
undetectable
3jb2A-3vohA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1


(Mus musculus)
PF00459
(Inositol_P)
3 ARG A 248
ASP A 244
ASP A 274
None
0.93A 3jb2A-4as5A:
undetectable
3jb2A-4as5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE


(Ralstonia sp.
DSMZ 6428)
PF13561
(adh_short_C2)
3 ARG A 113
ASP A  60
ASP A 109
None
NAP  A1250 (-3.3A)
None
0.90A 3jb2A-4bmsA:
3.5
3jb2A-4bmsA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsz ANKYRIN
REPEAT-CONTAINING
PROTEIN YAR1


(Saccharomyces
cerevisiae)
PF12796
(Ank_2)
3 ARG B 123
ASP B 119
ASP B 129
None
0.85A 3jb2A-4bszB:
undetectable
3jb2A-4bszB:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190


(Saccharomyces
cerevisiae)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
3 ARG A1295
ASP A1298
ASP A1268
None
0.74A 3jb2A-4c3hA:
undetectable
3jb2A-4c3hA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9f GLYCEROL 3-PHOSPHATE
PHOSPHATASE


(Mycobacterium
tuberculosis)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
3 ARG A 210
ASP A 237
ASP A 212
None
0.89A 3jb2A-4i9fA:
undetectable
3jb2A-4i9fA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16


(Saccharomyces
cerevisiae)
PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N)
3 ARG A 309
ASP A 186
ASP A 313
None
0.81A 3jb2A-4j7qA:
undetectable
3jb2A-4j7qA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB


(Escherichia
coli)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
3 ARG A 315
ASP A 323
ASP A 316
None
0.86A 3jb2A-4lq1A:
undetectable
3jb2A-4lq1A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
3 ARG A 225
ASP A  27
ASP A 222
None
0.91A 3jb2A-4lxfA:
undetectable
3jb2A-4lxfA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2t UNCHARACTERIZED
PROTEIN


(Parabacteroides
distasonis)
PF16109
(DUF4827)
3 ARG A 154
ASP A  76
ASP A 153
None
0.86A 3jb2A-4o2tA:
undetectable
3jb2A-4o2tA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica)
PF12468
(TTSSLRR)
3 ARG A 402
ASP A 419
ASP A 422
None
0.78A 3jb2A-4ow2A:
undetectable
3jb2A-4ow2A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxc E3 UBIQUITIN-PROTEIN
LIGASE XIAP


(Homo sapiens)
PF00653
(BIR)
3 ARG A  72
ASP A  77
ASP A  71
None
0.81A 3jb2A-4oxcA:
undetectable
3jb2A-4oxcA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF13229
(Beta_helix)
3 ARG A 369
ASP A 317
ASP A 368
None
0.72A 3jb2A-4ozyA:
undetectable
3jb2A-4ozyA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE


(Caldicellulosiruptor
bescii)
PF00331
(Glyco_hydro_10)
3 ARG A 259
ASP A 316
ASP A 257
None
0.67A 3jb2A-4pmdA:
undetectable
3jb2A-4pmdA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfp ACIDIC PHOSPHOLIPASE
A2 5


(Trimeresurus
stejnegeri)
PF00068
(Phospholip_A2_1)
3 ARG A  97
ASP A 101
ASP A  98
None
0.87A 3jb2A-4rfpA:
undetectable
3jb2A-4rfpA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN


(Salmonella
enterica)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1)
3 ARG A1367
ASP A1379
ASP A1365
None
0.92A 3jb2A-4u48A:
undetectable
3jb2A-4u48A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhb IRON-CHELATOR
UTILIZATION PROTEIN


(Thermobifida
fusca)
PF04954
(SIP)
PF08021
(FAD_binding_9)
3 ARG A  92
ASP A  36
ASP A 104
None
0.79A 3jb2A-4yhbA:
4.3
3jb2A-4yhbA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A


(Oryctolagus
cuniculus)
PF01399
(PCI)
3 ARG A 476
ASP A 479
ASP A 473
None
0.82A 3jb2A-5a5tA:
2.0
3jb2A-5a5tA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb7 OUTER CAPSID PROTEIN
VP4


(Rotavirus A)
no annotation 3 ARG A 170
ASP A 195
ASP A 171
None
0.69A 3jb2A-5cb7A:
undetectable
3jb2A-5cb7A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
3 ARG A 314
ASP A 319
ASP A  35
None
0.78A 3jb2A-5ce9A:
undetectable
3jb2A-5ce9A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgz 4-OXALMESACONATE
HYDRATASE


(Pseudomonas
putida)
PF02585
(PIG-L)
3 ARG A  46
ASP A  86
ASP A  89
None
GOL  A 308 (-3.3A)
None
0.83A 3jb2A-5cgzA:
2.4
3jb2A-5cgzA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4w PUTATIVE HEAT SHOCK
PROTEIN


(Chaetomium
thermophilum)
PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small)
3 ARG A 823
ASP A 820
ASP A 822
None
0.92A 3jb2A-5d4wA:
2.2
3jb2A-5d4wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dan 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE


(Thermotoga
maritima)
PF00248
(Aldo_ket_red)
3 ARG A 151
ASP A 168
ASP A 182
None
0.68A 3jb2A-5danA:
undetectable
3jb2A-5danA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dux GALECTIN-4

(Homo sapiens)
no annotation 3 ARG B  67
ASP B 141
ASP B  69
LAT  B 201 (-2.6A)
None
None
0.74A 3jb2A-5duxB:
undetectable
3jb2A-5duxB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2h BETA-LACTAMASE

(Mycolicibacterium
smegmatis)
PF00144
(Beta-lactamase)
3 ARG A  50
ASP A 224
ASP A  51
None
0.91A 3jb2A-5e2hA:
undetectable
3jb2A-5e2hA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1


(Homo sapiens)
PF03071
(GNT-I)
PF15711
(ILEI)
3 ARG A 129
ASP A 122
ASP A 179
None
0.75A 3jb2A-5gggA:
undetectable
3jb2A-5gggA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD


(Escherichia
coli)
PF00270
(DEAD)
3 ARG A 135
ASP A 169
ASP A 138
None
0.88A 3jb2A-5gjuA:
undetectable
3jb2A-5gjuA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcd RHIPICEPHALUS
MICROPLUS RACI2


(Rhipicephalus
microplus)
no annotation 3 ARG D  29
ASP D  24
ASP D  49
None
0.92A 3jb2A-5hcdD:
undetectable
3jb2A-5hcdD:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
3 ARG A 594
ASP A 597
ASP A 572
None
0.72A 3jb2A-5hqbA:
undetectable
3jb2A-5hqbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN


(Paraburkholderia
phymatum)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
3 ARG A 221
ASP A 141
ASP A 165
None
0.86A 3jb2A-5iduA:
undetectable
3jb2A-5iduA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA


(Geobacillus
stearothermophilus)
no annotation 3 ARG B 130
ASP B 164
ASP B 133
None
0.89A 3jb2A-5ivlB:
3.0
3jb2A-5ivlB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY


(Thermomonospora
curvata)
PF04261
(Dyp_perox)
3 ARG A  97
ASP A 185
ASP A  93
None
0.89A 3jb2A-5jxuA:
undetectable
3jb2A-5jxuA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE


(Caenorhabditis
elegans)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
3 ARG A  90
ASP A 115
ASP A  91
None
0.88A 3jb2A-5k3jA:
undetectable
3jb2A-5k3jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE


(Aspergillus
terreus)
PF11991
(Trp_DMAT)
3 ARG A 104
ASP A 182
ASP A 179
GST  A 502 ( 3.4A)
None
GST  A 502 ( 4.4A)
0.88A 3jb2A-5kd0A:
undetectable
3jb2A-5kd0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN


(Bacteroides
thetaiotaomicron)
PF17132
(Glyco_hydro_106)
3 ARG A 637
ASP A 653
ASP A 636
None
0.72A 3jb2A-5mqmA:
undetectable
3jb2A-5mqmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1


(Saccharomyces
cerevisiae)
PF13086
(AAA_11)
PF13087
(AAA_12)
3 ARG A1841
ASP A1849
ASP A1842
None
GOL  A2049 ( 4.6A)
None
0.72A 3jb2A-5mznA:
3.3
3jb2A-5mznA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE


(Bacteroides
thetaiotaomicron)
no annotation 3 ARG A 174
ASP A 177
ASP A 142
None
0.83A 3jb2A-5olsA:
undetectable
3jb2A-5olsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D


(Cellvibrio
japonicus)
no annotation 3 ARG A 425
ASP A 381
ASP A 373
None
0.66A 3jb2A-5oydA:
undetectable
3jb2A-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN


(Escherichia
coli;
Streptococcus
pyogenes)
PF12892
(FctA)
PF13416
(SBP_bac_8)
3 ARG A 481
ASP A 460
ASP A 484
None
0.88A 3jb2A-5ttdA:
undetectable
3jb2A-5ttdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN


(Human
alphaherpesvirus
1)
PF03970
(Herpes_UL37_1)
3 ARG A  28
ASP A  79
ASP A  23
None
0.87A 3jb2A-5vylA:
2.2
3jb2A-5vylA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN


(Homo sapiens;
Homo sapiens)
no annotation
no annotation
3 ARG L 214
ASP L 209
ASP H  61
None
0.90A 3jb2A-5whzL:
undetectable
3jb2A-5whzL:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6a ENDOGLUCANASE,
PUTATIVE


(Aspergillus
fumigatus)
no annotation 3 ARG A  58
ASP A  45
ASP A  53
None
0.62A 3jb2A-5x6aA:
undetectable
3jb2A-5x6aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS


(Neisseria
gonorrhoeae)
no annotation 3 ARG A 346
ASP A 360
ASP A 343
None
0.90A 3jb2A-5x9wA:
2.0
3jb2A-5x9wA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xox TRNA(HIS)
GUANYLYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF04446
(Thg1)
PF14413
(Thg1C)
3 ARG A 133
ASP A  77
ASP A 131
None
GTP  A 301 (-2.4A)
None
0.70A 3jb2A-5xoxA:
undetectable
3jb2A-5xoxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyf TERF1-INTERACTING
NUCLEAR FACTOR 2


(Homo sapiens)
no annotation 3 ARG A  52
ASP A  96
ASP A 103
None
0.79A 3jb2A-5xyfA:
undetectable
3jb2A-5xyfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3x BETA-XYLANASE

(Caldicellulosiruptor
owensensis)
no annotation 3 ARG A 259
ASP A 316
ASP A 257
None
0.66A 3jb2A-5y3xA:
undetectable
3jb2A-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygu DIAMINOPIMELATE
EPIMERASE


(Escherichia
coli)
no annotation 3 ARG A  96
ASP A  53
ASP A  57
None
0.89A 3jb2A-5yguA:
undetectable
3jb2A-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri)
no annotation 3 ARG A 341
ASP A 425
ASP A 465
None
0.94A 3jb2A-6byiA:
undetectable
3jb2A-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1q SOLUBLE CYTOCHROME
B562, C5A
ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1 CHIMERA


(Escherichia
coli;
Homo sapiens)
no annotation 3 ARG B 284
ASP B 277
ASP B 281
None
0.84A 3jb2A-6c1qB:
undetectable
3jb2A-6c1qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA


(Pyrococcus
furiosus)
no annotation 3 ARG L 201
ASP L 263
ASP L 202
None
0.77A 3jb2A-6cfwL:
undetectable
3jb2A-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE


(Paracoccus
denitrificans)
no annotation 3 ARG A 342
ASP A 335
ASP A 340
None
0.91A 3jb2A-6es9A:
2.2
3jb2A-6es9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-)
no annotation 3 ARG A  68
ASP A  63
ASP A  94
GOL  A 502 (-3.9A)
None
GOL  A 501 ( 4.8A)
0.91A 3jb2A-6ft5A:
undetectable
3jb2A-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzv PROCOLLAGEN
C-ENDOPEPTIDASE
ENHANCER 1


(Homo sapiens)
no annotation 3 ARG D 189
ASP D 233
ASP D 185
None
CA  D 302 (-3.1A)
None
0.84A 3jb2A-6fzvD:
undetectable
3jb2A-6fzvD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1


(Mus musculus;
Mus musculus)
no annotation
no annotation
3 ARG B  51
ASP H  51
ASP B  94
None
0.84A 3jb2A-6g72B:
undetectable
3jb2A-6g72B:
undetectable