SIMILAR PATTERNS OF AMINO ACIDS FOR 3JAY_A_SAMA1101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLU A 370
ARG A 221
VAL A 251
ILE A 317
ASN A 315
 None
 1.20A 3jayA-1gytA:
0.0		 3jayA-1gytA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2h HYPOTHETICAL PROTEIN
TM1643

(Thermotoga
maritima) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		5 ASN A 210
VAL A  53
ILE A  78
ASN A 164
GLU A  54
 None
None
NAD  A1242 (-4.3A)
NAD  A1242 (-2.6A)
None
 1.29A 3jayA-1h2hA:
0.0		 3jayA-1h2hA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		5 GLU A 223
GLU A 224
ARG A  19
VAL A  20
ILE A  22
 None
 1.44A 3jayA-1j5tA:
0.0		 3jayA-1j5tA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		5 GLU A  83
ARG A 105
VAL A 171
ASP A 121
ILE A 122
 None
 1.41A 3jayA-1mpoA:
0.0		 3jayA-1mpoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od5 GLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		5 MET A  68
GLU A 333
ARG A 350
VAL A 372
GLU A 440
 None
 1.42A 3jayA-1od5A:
0.3		 3jayA-1od5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		5 GLU A 395
VAL A 427
ASP A 417
ILE A 423
GLU A 426
 None
 1.36A 3jayA-1pxyA:
0.1		 3jayA-1pxyA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		5 GLU A  72
VAL A 114
ASP A  93
ILE A   7
ASN A   9
 None
 1.39A 3jayA-1qhxA:
3.6		 3jayA-1qhxA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASN A  79
GLU A 130
VAL A 285
ILE A 282
GLU A 283
 None
 1.46A 3jayA-1tkiA:
1.0		 3jayA-1tkiA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN

(Thermotoga
maritima) 		PF04309
(G3P_antiterm) 		5 GLU A 150
GLU A 151
ARG A 153
VAL A 159
ILE A 162
 None
 1.20A 3jayA-1vkfA:
0.0		 3jayA-1vkfA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8i PUTATIVE VAPC
RIBONUCLEASE AF_1683

(Archaeoglobus
fulgidus) 		PF01850
(PIN) 		5 SER A 106
GLU A  48
VAL A  68
ILE A  75
ASN A  43
 None
 1.37A 3jayA-1w8iA:
undetectable		 3jayA-1w8iA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLU A 319
ARG A 351
VAL A 258
ASP A 335
ILE A 336
 CO  A1001 (-2.6A)
None
None
None
None
 1.29A 3jayA-1wn1A:
undetectable		 3jayA-1wn1A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 GLU B 286
ARG B 289
VAL B  56
ASP B 281
ILE B 280
 None
 1.41A 3jayA-2f2aB:
0.8		 3jayA-2f2aB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		5 GLU A 395
ARG A 297
ARG A 595
ASP A 425
ILE A 424
 None
None
None
ZN  A   1 (-2.4A)
None
 1.34A 3jayA-2fuqA:
1.7		 3jayA-2fuqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		5 MET A 315
GLU A 242
VAL A 201
ASP A 249
ILE A 250
 None
 1.21A 3jayA-2gz6A:
undetectable		 3jayA-2gz6A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2w PHOSPHOHEPTOSE
ISOMERASE

(Escherichia
coli) 		PF13580
(SIS_2) 		5 GLU A 106
VAL A  85
ASP A  99
ILE A 100
ASN A 126
 None
 1.31A 3jayA-2i2wA:
undetectable		 3jayA-2i2wA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt4 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Bacillus
subtilis) 		PF08529
(NusA_N) 		5 GLU A   4
VAL A 118
ASP A   7
ILE A  11
GLU A  15
 None
 1.20A 3jayA-2mt4A:
undetectable		 3jayA-2mt4A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 ASN A 298
GLU A 297
VAL A 267
ILE A 344
ASN A 345
 None
 1.27A 3jayA-2nqoA:
undetectable		 3jayA-2nqoA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 5 MET A 239
GLU A 222
ARG A 141
VAL A  17
ILE A  14
 None
 1.48A 3jayA-2q9uA:
undetectable		 3jayA-2q9uA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 SER A 169
MET A 210
GLU A  14
ARG A  36
VAL A   4
 None
 1.46A 3jayA-3a1nA:
undetectable		 3jayA-3a1nA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE
ASPARTOKINASE

(Corynebacterium
glutamicum;
Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
PF01842
(ACT)
PF13840
(ACT_7) 		5 SER A 302
VAL B  33
ASP B  60
ILE B  23
GLU B  29
 None
None
None
THR  B 201 ( 4.7A)
None
 1.19A 3jayA-3ab4A:
1.6		 3jayA-3ab4A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgy POLYNUCLEOTIDE
5'-TRIPHOSPHATASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 GLU A 210
GLU A  39
VAL A 231
ASP A 189
ILE A 188
 None
 1.42A 3jayA-3bgyA:
undetectable		 3jayA-3bgyA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byh FIMBRIN ABD2

(Homo sapiens) 		PF00307
(CH) 		5 GLU B 395
VAL B 427
ASP B 417
ILE B 423
GLU B 426
 None
 1.35A 3jayA-3byhB:
undetectable		 3jayA-3byhB:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		5 ASN A 357
GLU A 269
VAL A 391
ILE A 380
ASN A 379
 None
 1.33A 3jayA-3ff1A:
undetectable		 3jayA-3ff1A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4c TRANSCRIPTION FACTOR
TFIIB-LIKE

(Trypanosoma
brucei) 		no annotation 5 SER A 192
GLU A 155
GLU A 156
VAL A 145
ILE A 183
 None
 1.37A 3jayA-3h4cA:
undetectable		 3jayA-3h4cA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		5 GLU A 370
VAL A 343
ASP A 324
ILE A 321
ASN A 320
 None
 1.38A 3jayA-3i6rA:
undetectable		 3jayA-3i6rA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma2 METALLOPROTEINASE
INHIBITOR 1

(Homo sapiens) 		PF00965
(TIMP) 		5 ASN B 406
GLU B 381
GLU B 382
VAL B 361
ILE B 385
 None
 1.43A 3jayA-3ma2B:
undetectable		 3jayA-3ma2B:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obw PROTEIN PELOTA
HOMOLOG

(Sulfolobus
solfataricus) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		5 GLU A 278
VAL A 285
ASP A 308
ILE A 309
ASN A 311
 None
 1.38A 3jayA-3obwA:
undetectable		 3jayA-3obwA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE

(Thermotoga
maritima) 		PF00701
(DHDPS) 		5 ASN A  15
GLU A 268
GLU A 266
VAL A 281
GLU A 278
 None
 1.15A 3jayA-3pb0A:
undetectable		 3jayA-3pb0A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjl 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Bacillus
licheniformis) 		PF00171
(Aldedh) 		5 GLU A 336
GLU A 303
VAL A 294
ASP A 301
ILE A 450
 None
 1.44A 3jayA-3rjlA:
undetectable		 3jayA-3rjlA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v96 METALLOPROTEINASE
INHIBITOR 1

(Homo sapiens) 		PF00965
(TIMP) 		5 ASN A 106
GLU A  81
GLU A  82
VAL A  61
ILE A  85
 None
 1.35A 3jayA-3v96A:
undetectable		 3jayA-3v96A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL4
MRPL15
MRPL49

(Sus scrofa;
Sus scrofa;
Sus scrofa) 		PF00573
(Ribosomal_L4)
PF00828
(Ribosomal_L27A)
no annotation 		5 SER P  33
GLU l 142
VAL F 176
ASP F  94
ILE F  95
 U  A 212 ( 2.7A)
A  A 213 ( 4.4A)
None
U  A 212 ( 3.7A)
None
 1.32A 3jayA-4ce4P:
undetectable		 3jayA-4ce4P:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		5 ARG P 475
VAL P 476
ASP P 458
ILE P 457
GLU P 472
 None
 1.49A 3jayA-4crmP:
undetectable		 3jayA-4crmP:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		5 GLU A 257
VAL A 285
ASP A 260
ILE A 271
ASN A 273
 None
 1.49A 3jayA-4e4jA:
undetectable		 3jayA-4e4jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed9 CAIB/BAIF FAMILY
PROTEIN

(Brucella suis) 		PF02515
(CoA_transf_3) 		5 ASN A  68
GLU A  13
GLU A  38
ILE A 374
GLU A 377
 None
None
None
None
NHE  A 403 (-3.6A)
 1.29A 3jayA-4ed9A:
undetectable		 3jayA-4ed9A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 MET A 223
GLU A 245
VAL A 254
ILE A 251
GLU A 255
 None
 1.34A 3jayA-4faiA:
undetectable		 3jayA-4faiA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 ASN A   8
GLU A 291
VAL A 110
ILE A  13
ASN A  12
 None
 1.36A 3jayA-4fn5A:
undetectable		 3jayA-4fn5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		5 GLU A  15
GLU A   5
VAL A  24
ASP A  20
ILE A  22
 None
 1.20A 3jayA-4kp2A:
undetectable		 3jayA-4kp2A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		5 ASN A 199
SER A 289
GLU A 191
VAL A 161
GLU A 162
 PD2  A 401 ( 4.5A)
None
NI  A 402 ( 2.6A)
None
None
 1.48A 3jayA-4lxlA:
undetectable		 3jayA-4lxlA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 SER A 104
GLU A 233
ASP A 108
ILE A 137
ASN A 140
 None
 1.47A 3jayA-4npaA:
undetectable		 3jayA-4npaA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		5 SER A 284
MET A 286
ARG A 193
VAL A 194
ASP A 255
 GOL  A 403 (-4.7A)
None
OCS  A 223 ( 4.9A)
None
None
 1.46A 3jayA-4o5aA:
undetectable		 3jayA-4o5aA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ASN A 230
SER A 240
VAL A 191
ASP A 459
ILE A 457
 None
 1.41A 3jayA-4pd3A:
undetectable		 3jayA-4pd3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxw CARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 1

(Homo sapiens) 		PF07686
(V-set) 		5 ASN A  61
SER A  62
ARG A  43
ASP A  82
ASN A  81
 None
None
MLA  A 201 (-2.8A)
None
None
 1.41A 3jayA-4qxwA:
undetectable		 3jayA-4qxwA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 MET A 390
VAL A 318
ILE A 300
ASN A 301
GLU A 314
 None
 1.34A 3jayA-4r8eA:
1.1		 3jayA-4r8eA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		5 ASN A 575
GLU A 551
ARG A 524
VAL A 525
ILE A 559
 None
 1.45A 3jayA-4uirA:
undetectable		 3jayA-4uirA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLU A 109
VAL A 116
ASP A 168
ILE A 169
ASN A  90
 None
 1.35A 3jayA-4usfA:
3.0		 3jayA-4usfA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE

(Streptomyces
hygroscopicus) 		no annotation 5 MET A  56
GLU A 334
VAL A 146
ILE A 133
ASN A 131
 None
None
None
None
3HB  A1341 (-4.3A)
 1.20A 3jayA-5a3kA:
undetectable		 3jayA-5a3kA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8g PP-BRD20

(Trypanosoma
brucei) 		PF00439
(Bromodomain) 		5 ASN A  95
ARG A 121
ASP A  88
ILE A  85
ASN A  87
 None
 1.29A 3jayA-5c8gA:
undetectable		 3jayA-5c8gA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		5 GLU A 466
ARG A 463
VAL A 436
ASP A 470
ILE A 471
 None
 1.43A 3jayA-5djsA:
2.7		 3jayA-5djsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5far 7,8-DIHYDRONEOPTERIN
ALDOLASE

(Bacillus cereus) 		PF02152
(FolB) 		5 ARG A 117
VAL A  30
ASP A  82
ILE A  79
ASN A  78
 None
 1.34A 3jayA-5farA:
undetectable		 3jayA-5farA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fk0 COATOMER SUBUNIT
DELTA

(Saccharomyces
cerevisiae) 		PF00928
(Adap_comp_sub) 		5 SER A 410
VAL A 457
ASP A 444
ILE A 445
ASN A 446
 None
 1.45A 3jayA-5fk0A:
undetectable		 3jayA-5fk0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		5 GLU A 128
ARG A 255
ASP A 204
ILE A 206
ASN A 205
 None
None
MG  A 304 ( 4.5A)
None
None
 1.02A 3jayA-5hmmA:
undetectable		 3jayA-5hmmA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 ASN A 967
MET A 932
VAL A 818
ILE A 810
ASN A 974
 None
 1.44A 3jayA-5i6hA:
2.4		 3jayA-5i6hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 GLU V 619
VAL V 560
ASP V 556
ILE V 558
ASN V 603
 None
 1.25A 3jayA-5iy6V:
undetectable		 3jayA-5iy6V:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		5 SER A  16
GLU A 207
VAL A 170
ASP A  41
ILE A 201
 None
 1.48A 3jayA-5izdA:
undetectable		 3jayA-5izdA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		5 MET A 241
GLU A 229
VAL A 218
ILE A  44
GLU A  47
 None
 1.26A 3jayA-5l9wA:
undetectable		 3jayA-5l9wA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ln1 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Saccharomyces
cerevisiae) 		PF13519
(VWA_2) 		5 SER A 116
VAL A  33
ASP A  11
ILE A  10
ASN A  12
 None
 1.46A 3jayA-5ln1A:
undetectable		 3jayA-5ln1A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lox PEPTIDASE

(Pseudomonas
aeruginosa) 		no annotation 5 SER A 223
ARG A  19
VAL A 186
ASP A 177
ILE A 180
 None
 1.44A 3jayA-5loxA:
undetectable		 3jayA-5loxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 5 SER C 171
MET C 203
VAL C 229
ILE C 165
GLU C 163
 None
 1.40A 3jayA-6cajC:
undetectable		 3jayA-6cajC:
undetectable