SIMILAR PATTERNS OF AMINO ACIDS FOR 3J7Z_A_ERYA9000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		3 LYS A   2
ILE A  96
PHE A  86
 None
 1.01A 3j7zS-1cjaA:
0.0
3j7za-1cjaA:
undetectable		 3j7zS-1cjaA:
17.42
3j7za-1cjaA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckm MRNA CAPPING ENZYME

(Paramecium
bursaria
Chlorella virus
1) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		3 LYS A 234
ILE A 256
PHE A 257
 GTP  A 899 (-2.6A)
None
None
 0.97A 3j7zS-1ckmA:
0.0
3j7za-1ckmA:
undetectable		 3j7zS-1ckmA:
17.48
3j7za-1ckmA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		3 LYS A 403
ILE A 432
PHE A 460
 None
 0.88A 3j7zS-1gjuA:
0.0
3j7za-1gjuA:
undetectable		 3j7zS-1gjuA:
10.20
3j7za-1gjuA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hno D3,D2-ENOYL COA
ISOMERASE ECI1

(Saccharomyces
cerevisiae) 		PF00378
(ECH_1) 		3 LYS A 168
ILE A  58
PHE A  20
 EDO  A 281 (-2.8A)
None
None
 0.96A 3j7zS-1hnoA:
undetectable
3j7za-1hnoA:
undetectable		 3j7zS-1hnoA:
15.96
3j7za-1hnoA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LYS X 212
ILE X 131
PHE X 130
 None
 0.75A 3j7zS-1js1X:
0.0
3j7za-1js1X:
undetectable		 3j7zS-1js1X:
15.92
3j7za-1js1X:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 LYS A 171
ILE A 414
PHE A 415
 None
None
RS7  A 841 ( 4.8A)
 0.86A 3j7zS-1loxA:
0.8
3j7za-1loxA:
undetectable		 3j7zS-1loxA:
9.37
3j7za-1loxA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		3 LYS A 404
ILE A  38
PHE A 523
 None
 0.96A 3j7zS-1n7uA:
0.0
3j7za-1n7uA:
undetectable		 3j7zS-1n7uA:
11.03
3j7za-1n7uA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyz HYPOTHETICAL PROTEIN
YIBA

(Escherichia
coli) 		PF13646
(HEAT_2) 		3 LYS A 121
ILE A  60
PHE A  62
 None
 0.89A 3j7zS-1oyzA:
0.0
3j7za-1oyzA:
undetectable		 3j7zS-1oyzA:
18.57
3j7za-1oyzA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 LYS A  71
ILE A 223
PHE A 234
 None
 1.00A 3j7zS-1pguA:
0.0
3j7za-1pguA:
undetectable		 3j7zS-1pguA:
10.34
3j7za-1pguA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE

(Clostridium
perfringens) 		PF00722
(Glyco_hydro_16) 		3 LYS A 227
ILE A 294
PHE A 302
 None
 0.98A 3j7zS-1upsA:
undetectable
3j7za-1upsA:
undetectable		 3j7zS-1upsA:
14.94
3j7za-1upsA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
SISTER CHROMATID
COHESION PROTEIN 1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF02463
(SMC_N)
PF04824
(Rad21_Rec8) 		3 LYS E 521
ILE A1186
PHE A1154
 None
 0.92A 3j7zS-1w1wE:
undetectable
3j7za-1w1wE:
undetectable		 3j7zS-1w1wE:
25.60
3j7za-1w1wE:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Lactococcus
lactis) 		PF01634
(HisG) 		3 LYS E 136
ILE E  55
PHE E  57
 None
 0.90A 3j7zS-1z7mE:
undetectable
3j7za-1z7mE:
undetectable		 3j7zS-1z7mE:
22.66
3j7za-1z7mE:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 LYS A 381
ILE A  45
PHE A  37
 None
 1.00A 3j7zS-1zb7A:
undetectable
3j7za-1zb7A:
undetectable		 3j7zS-1zb7A:
13.89
3j7za-1zb7A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 LYS A 995
ILE A 843
PHE A 842
 None
None
GOL  A 998 ( 4.2A)
 0.89A 3j7zS-1zy4A:
undetectable
3j7za-1zy4A:
undetectable		 3j7zS-1zy4A:
18.11
3j7za-1zy4A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ak3 ADENYLATE KINASE
ISOENZYME-3

(Bos taurus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		3 LYS A  18
ILE A  58
PHE A  57
 None
AMP  A 226 (-4.5A)
None
 0.68A 3j7zS-2ak3A:
undetectable
3j7za-2ak3A:
undetectable		 3j7zS-2ak3A:
20.00
3j7za-2ak3A:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 LYS A 131
ILE A  65
PHE A  60
 None
 0.99A 3j7zS-2akjA:
undetectable
3j7za-2akjA:
undetectable		 3j7zS-2akjA:
11.63
3j7za-2akjA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 LYS A1502
ILE A1583
PHE A1582
 None
 0.89A 3j7zS-2b39A:
undetectable
3j7za-2b39A:
undetectable		 3j7zS-2b39A:
5.03
3j7za-2b39A:
1.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT

(Homo sapiens) 		PF00676
(E1_dh) 		3 LYS A  56
ILE A 216
PHE A 279
 None
 0.77A 3j7zS-2bfeA:
undetectable
3j7za-2bfeA:
undetectable		 3j7zS-2bfeA:
13.72
3j7za-2bfeA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpr EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC) 		3 LYS A 476
ILE A 485
PHE A 486
 None
 1.00A 3j7zS-2cprA:
undetectable
3j7za-2cprA:
undetectable		 3j7zS-2cprA:
20.15
3j7za-2cprA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		3 LYS A 371
ILE A 189
PHE A 190
 None
NAP  A1518 (-4.8A)
None
 0.91A 3j7zS-2ehqA:
undetectable
3j7za-2ehqA:
undetectable		 3j7zS-2ehqA:
13.27
3j7za-2ehqA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		3 LYS A  37
ILE A 117
PHE A 178
 None
 0.99A 3j7zS-2hrzA:
undetectable
3j7za-2hrzA:
undetectable		 3j7zS-2hrzA:
15.70
3j7za-2hrzA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN

(Mycoplasma
arthritidis) 		PF09245
(MA-Mit) 		3 LYS G 185
ILE G 122
PHE G 121
 None
 0.93A 3j7zS-2icwG:
undetectable
3j7za-2icwG:
undetectable		 3j7zS-2icwG:
21.66
3j7za-2icwG:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 LYS A 687
ILE A 598
PHE A 610
 None
 0.90A 3j7zS-2o8rA:
undetectable
3j7za-2o8rA:
undetectable		 3j7zS-2o8rA:
10.77
3j7za-2o8rA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 LYS A 687
ILE A 611
PHE A 610
 None
 0.91A 3j7zS-2o8rA:
undetectable
3j7za-2o8rA:
undetectable		 3j7zS-2o8rA:
10.77
3j7za-2o8rA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyr UPF0341 PROTEIN YHIQ

(Shigella
flexneri) 		PF04445
(SAM_MT) 		3 LYS A 218
ILE A  55
PHE A  56
 None
 0.91A 3j7zS-2oyrA:
undetectable
3j7za-2oyrA:
undetectable		 3j7zS-2oyrA:
15.50
3j7za-2oyrA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 LYS A 241
ILE A 269
PHE A 267
 None
 0.95A 3j7zS-2pxjA:
undetectable
3j7za-2pxjA:
undetectable		 3j7zS-2pxjA:
16.56
3j7za-2pxjA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Listeria
monocytogenes) 		PF06751
(EutB) 		3 LYS A  28
ILE A 391
PHE A 390
 None
 0.97A 3j7zS-2qezA:
undetectable
3j7za-2qezA:
undetectable		 3j7zS-2qezA:
15.14
3j7za-2qezA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		3 LYS A 360
ILE A 294
PHE A 293
 None
 0.98A 3j7zS-2qneA:
undetectable
3j7za-2qneA:
undetectable		 3j7zS-2qneA:
14.55
3j7za-2qneA:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		3 LYS A  11
ILE A 200
PHE A  95
 None
 0.79A 3j7zS-2v25A:
undetectable
3j7za-2v25A:
undetectable		 3j7zS-2v25A:
20.25
3j7za-2v25A:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		3 LYS A 232
ILE A 197
PHE A 130
 ANP  A 401 (-2.9A)
None
None
 0.93A 3j7zS-2vugA:
undetectable
3j7za-2vugA:
undetectable		 3j7zS-2vugA:
15.92
3j7za-2vugA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Candida
albicans) 		PF01704
(UDPGP) 		3 LYS A 444
ILE A 267
PHE A 268
 None
 0.62A 3j7zS-2yqhA:
undetectable
3j7za-2yqhA:
undetectable		 3j7zS-2yqhA:
13.98
3j7za-2yqhA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		3 LYS A 120
ILE A 275
PHE A 276
 None
 0.98A 3j7zS-2yzsA:
undetectable
3j7za-2yzsA:
undetectable		 3j7zS-2yzsA:
15.91
3j7za-2yzsA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 LYS A   1
ILE A 355
PHE A 346
 None
 0.79A 3j7zS-3acpA:
undetectable
3j7za-3acpA:
undetectable		 3j7zS-3acpA:
15.23
3j7za-3acpA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		3 LYS A 266
ILE A 218
PHE A 125
 None
 0.98A 3j7zS-3bdkA:
undetectable
3j7za-3bdkA:
undetectable		 3j7zS-3bdkA:
13.92
3j7za-3bdkA:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY

(Bacillus
anthracis) 		PF02567
(PhzC-PhzF) 		3 LYS A 264
ILE A  24
PHE A  50
 None
 0.98A 3j7zS-3ednA:
undetectable
3j7za-3ednA:
undetectable		 3j7zS-3ednA:
18.18
3j7za-3ednA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi8 CHOLINE KINASE

(Plasmodium
falciparum) 		PF01633
(Choline_kinase) 		3 LYS A 432
ILE A 318
PHE A 321
 None
 0.74A 3j7zS-3fi8A:
undetectable
3j7za-3fi8A:
undetectable		 3j7zS-3fi8A:
14.64
3j7za-3fi8A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		3 LYS A 726
ILE A 211
PHE A 210
 None
 0.99A 3j7zS-3h09A:
undetectable
3j7za-3h09A:
undetectable		 3j7zS-3h09A:
9.02
3j7za-3h09A:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES1
40S RIBOSOMAL
PROTEIN US11

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF01015
(Ribosomal_S3Ae)
PF00411
(Ribosomal_S11) 		3 LYS B  83
ILE P  33
PHE P  41
 None
None
U  A 986 ( 4.4A)
 0.96A 3j7zS-3j7aB:
undetectable
3j7za-3j7aB:
undetectable		 3j7zS-3j7aB:
18.22
3j7za-3j7aB:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		3 LYS A 186
ILE A 358
PHE A  84
 None
 0.86A 3j7zS-3k2kA:
undetectable
3j7za-3k2kA:
undetectable		 3j7zS-3k2kA:
13.40
3j7za-3k2kA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 LYS A 163
ILE A 260
PHE A 264
 FMT  A 301 (-3.3A)
None
None
 0.75A 3j7zS-3l0gA:
undetectable
3j7za-3l0gA:
undetectable		 3j7zS-3l0gA:
16.50
3j7za-3l0gA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica) 		PF00923
(TAL_FSA) 		3 LYS A 139
ILE A  28
PHE A  31
 None
 1.00A 3j7zS-3m16A:
undetectable
3j7za-3m16A:
undetectable		 3j7zS-3m16A:
19.28
3j7za-3m16A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 16F6 - HEAVY CHAIN
ENVELOPE
GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN

(Mus musculus;
Sudan
ebolavirus;
Sudan
ebolavirus) 		PF07654
(C1-set)
PF07686
(V-set)
PF01611
(Filo_glycop)
no annotation 		3 LYS H  77
ILE I  48
PHE J 592
 None
 0.92A 3j7zS-3s88H:
undetectable
3j7za-3s88H:
undetectable		 3j7zS-3s88H:
19.59
3j7za-3s88H:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 LYS A 224
ILE A 336
PHE A 379
 None
 0.94A 3j7zS-3tqiA:
undetectable
3j7za-3tqiA:
undetectable		 3j7zS-3tqiA:
11.70
3j7za-3tqiA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		3 LYS A 173
ILE A  26
PHE A  29
 None
 0.95A 3j7zS-3tr7A:
undetectable
3j7za-3tr7A:
undetectable		 3j7zS-3tr7A:
17.78
3j7za-3tr7A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v85 CYTH-LIKE
PHOSPHATASE

(Arabidopsis
thaliana) 		PF01928
(CYTH) 		3 LYS A 200
ILE A 182
PHE A 185
 CIT  A 301 (-2.8A)
None
None
 0.93A 3j7zS-3v85A:
undetectable
3j7za-3v85A:
undetectable		 3j7zS-3v85A:
19.62
3j7za-3v85A:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuu ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 LYS A 193
ILE A 215
PHE A 220
 None
 0.59A 3j7zS-3vuuA:
0.8
3j7za-3vuuA:
undetectable		 3j7zS-3vuuA:
17.45
3j7za-3vuuA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuv ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 LYS A 193
ILE A 215
PHE A 220
 None
 0.65A 3j7zS-3vuvA:
0.8
3j7za-3vuvA:
undetectable		 3j7zS-3vuvA:
15.66
3j7za-3vuvA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		3 LYS A  73
ILE A 141
PHE A 140
 None
 0.86A 3j7zS-3zfvA:
undetectable
3j7za-3zfvA:
undetectable		 3j7zS-3zfvA:
15.92
3j7za-3zfvA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		3 LYS A 224
ILE A 157
PHE A 156
 None
 0.74A 3j7zS-4bjuA:
undetectable
3j7za-4bjuA:
undetectable		 3j7zS-4bjuA:
13.48
3j7za-4bjuA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 LYS B1716
ILE B1268
PHE B1267
 None
 0.85A 3j7zS-4f92B:
undetectable
3j7za-4f92B:
undetectable		 3j7zS-4f92B:
5.33
3j7za-4f92B:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		3 LYS A 353
ILE A 207
PHE A 208
 None
 1.00A 3j7zS-4fidA:
undetectable
3j7za-4fidA:
undetectable		 3j7zS-4fidA:
16.72
3j7za-4fidA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 LYS A 734
ILE A 407
PHE A 495
 None
 0.92A 3j7zS-4iglA:
undetectable
3j7za-4iglA:
undetectable		 3j7zS-4iglA:
5.54
3j7za-4iglA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		3 LYS B 188
ILE A 110
PHE A 137
 None
None
OXL  A 401 (-4.5A)
 0.74A 3j7zS-4jn6B:
undetectable
3j7za-4jn6B:
undetectable		 3j7zS-4jn6B:
15.51
3j7za-4jn6B:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc3 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1

(Homo sapiens;
Homo sapiens) 		PF15095
(IL33)
PF07679
(I-set) 		3 LYS B 163
ILE A 250
PHE A 239
 None
 0.89A 3j7zS-4kc3B:
undetectable
3j7za-4kc3B:
undetectable		 3j7zS-4kc3B:
16.99
3j7za-4kc3B:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 LYS A 225
ILE A 380
PHE A 388
 None
 0.76A 3j7zS-4kcaA:
undetectable
3j7za-4kcaA:
undetectable		 3j7zS-4kcaA:
9.55
3j7za-4kcaA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE

(Thermomonospora
curvata;
Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		3 LYS B 207
ILE A 116
PHE A 143
 None
None
PYR  A 402 (-4.7A)
 0.72A 3j7zS-4lrsB:
undetectable
3j7za-4lrsB:
undetectable		 3j7zS-4lrsB:
14.24
3j7za-4lrsB:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		3 LYS A 269
ILE A 110
PHE A 113
 None
 0.95A 3j7zS-4lryA:
1.7
3j7za-4lryA:
undetectable		 3j7zS-4lryA:
15.98
3j7za-4lryA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 LYS A 242
ILE A 270
PHE A 268
 PD2  A 401 (-2.9A)
None
None
 0.90A 3j7zS-4lxlA:
undetectable
3j7za-4lxlA:
undetectable		 3j7zS-4lxlA:
15.30
3j7za-4lxlA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE

(Alicyclobacillus
acidocaldarius) 		PF00016
(RuBisCO_large) 		3 LYS A 406
ILE A 147
PHE A 148
 None
KCX  A 175 ( 3.9A)
None
 0.94A 3j7zS-4nasA:
undetectable
3j7za-4nasA:
undetectable		 3j7zS-4nasA:
14.82
3j7za-4nasA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE

(Streptomyces
globisporus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 LYS A 124
ILE A 182
PHE A 181
 None
 0.97A 3j7zS-4oo2A:
undetectable
3j7za-4oo2A:
undetectable		 3j7zS-4oo2A:
11.60
3j7za-4oo2A:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		3 LYS A 656
ILE A 467
PHE A 468
 None
 1.00A 3j7zS-4pkvA:
undetectable
3j7za-4pkvA:
undetectable		 3j7zS-4pkvA:
10.79
3j7za-4pkvA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmw DIS3-LIKE
EXONUCLEASE 2

(Mus musculus) 		PF00773
(RNB)
PF17216
(Rrp44_CSD1) 		3 LYS A 437
ILE A 300
PHE A 299
 None
 0.64A 3j7zS-4pmwA:
undetectable
3j7za-4pmwA:
undetectable		 3j7zS-4pmwA:
9.57
3j7za-4pmwA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF02940
(mRNA_triPase) 		3 LYS A 185
ILE A 202
PHE A 200
 None
 1.01A 3j7zS-4pn0A:
undetectable
3j7za-4pn0A:
undetectable		 3j7zS-4pn0A:
16.91
3j7za-4pn0A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE

(Bacteroides
fragilis) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 LYS A  20
ILE A 115
PHE A 111
 None
 0.81A 3j7zS-4pysA:
undetectable
3j7za-4pysA:
undetectable		 3j7zS-4pysA:
14.48
3j7za-4pysA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 LYS A 143
ILE A 250
PHE A 254
 None
 0.98A 3j7zS-4qeiA:
2.0
3j7za-4qeiA:
undetectable		 3j7zS-4qeiA:
10.05
3j7za-4qeiA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 LYS A 448
ILE A 374
PHE A 500
 None
 0.95A 3j7zS-4r04A:
undetectable
3j7za-4r04A:
undetectable		 3j7zS-4r04A:
5.14
3j7za-4r04A:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku CHLOROPHYLL A-B
BINDING PROTEIN 3,
CHLOROPLASTIC
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum;
Pisum sativum) 		PF00504
(Chloroa_b-bind)
PF00223
(PsaA_PsaB) 		3 LYS 3 148
ILE A 249
PHE A 248
 None
CLA  A1114 ( 4.6A)
None
 0.99A 3j7zS-4rku3:
undetectable
3j7za-4rku3:
undetectable		 3j7zS-4rku3:
19.77
3j7za-4rku3:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz2 SITE-DETERMINING
PROTEIN

(Geobacillus
thermodenitrificans) 		PF10609
(ParA) 		3 LYS A 218
ILE A  25
PHE A 138
 None
 1.00A 3j7zS-4rz2A:
undetectable
3j7za-4rz2A:
undetectable		 3j7zS-4rz2A:
17.97
3j7za-4rz2A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0h T-BOX TRANSCRIPTION
FACTOR TBX5
HOMEOBOX PROTEIN
NKX-2.5

(Homo sapiens;
Homo sapiens) 		PF00907
(T-box)
PF00046
(Homeobox) 		3 LYS B 158
ILE A 185
PHE A 201
 None
 0.66A 3j7zS-4s0hB:
undetectable
3j7za-4s0hB:
undetectable		 3j7zS-4s0hB:
23.16
3j7za-4s0hB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891

(Streptococcus
agalactiae) 		PF13561
(adh_short_C2) 		3 LYS A 140
ILE A  19
PHE A  43
 None
 0.93A 3j7zS-4u8gA:
undetectable
3j7za-4u8gA:
undetectable		 3j7zS-4u8gA:
15.77
3j7za-4u8gA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvj COHESIN SUBUNIT SCC3

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 743
ILE A 978
PHE A 979
 None
 0.67A 3j7zS-4uvjA:
0.9
3j7za-4uvjA:
undetectable		 3j7zS-4uvjA:
13.33
3j7za-4uvjA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 LYS A 243
ILE A 271
PHE A 269
 FE  A 402 ( 4.8A)
None
None
 0.89A 3j7zS-4xdoA:
undetectable
3j7za-4xdoA:
undetectable		 3j7zS-4xdoA:
16.20
3j7za-4xdoA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		3 LYS A 749
ILE A 173
PHE A 177
 None
 1.00A 3j7zS-4xjxA:
undetectable
3j7za-4xjxA:
undetectable		 3j7zS-4xjxA:
7.68
3j7za-4xjxA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1

(Homo sapiens;
Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
PF02100
(ODC_AZ) 		3 LYS A 168
ILE B 141
PHE B 173
 None
 0.84A 3j7zS-4zgzA:
undetectable
3j7za-4zgzA:
undetectable		 3j7zS-4zgzA:
14.65
3j7za-4zgzA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 LYS A 551
ILE A 465
PHE A 464
 None
 0.75A 3j7zS-4zlgA:
1.0
3j7za-4zlgA:
undetectable		 3j7zS-4zlgA:
9.91
3j7za-4zlgA:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		3 LYS A  97
ILE A 251
PHE A 225
 None
 0.91A 3j7zS-5cadA:
undetectable
3j7za-5cadA:
undetectable		 3j7zS-5cadA:
15.62
3j7za-5cadA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 LYS A 191
ILE A 174
PHE A 175
 None
 0.97A 3j7zS-5ek8A:
2.1
3j7za-5ek8A:
undetectable		 3j7zS-5ek8A:
11.15
3j7za-5ek8A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		3 LYS A 119
ILE A 242
PHE A 184
 None
 0.91A 3j7zS-5ewtA:
undetectable
3j7za-5ewtA:
undetectable		 3j7zS-5ewtA:
18.83
3j7za-5ewtA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		3 LYS A1422
ILE A1111
PHE A1112
 None
 0.67A 3j7zS-5ffjA:
undetectable
3j7za-5ffjA:
undetectable		 3j7zS-5ffjA:
6.54
3j7za-5ffjA:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 LYS A 146
ILE A   9
PHE A  10
 None
 0.87A 3j7zS-5h53A:
undetectable
3j7za-5h53A:
undetectable		 3j7zS-5h53A:
9.47
3j7za-5h53A:
2.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Paraburkholderia
graminis) 		PF13407
(Peripla_BP_4) 		3 LYS A  38
ILE A 158
PHE A 217
 64K  A 401 (-2.5A)
None
None
 0.94A 3j7zS-5hqjA:
undetectable
3j7za-5hqjA:
undetectable		 3j7zS-5hqjA:
18.12
3j7za-5hqjA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		3 LYS A 252
ILE A 146
PHE A 145
 HEB  A 501 (-3.3A)
HDD  A 503 ( 2.9A)
None
 0.99A 3j7zS-5ir6A:
0.5
3j7za-5ir6A:
undetectable		 3j7zS-5ir6A:
13.85
3j7za-5ir6A:
4.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		3 LYS A 374
ILE A 388
PHE A 391
 None
 1.00A 3j7zS-5j3nA:
undetectable
3j7za-5j3nA:
undetectable		 3j7zS-5j3nA:
15.21
3j7za-5j3nA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku1 MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		3 LYS A 315
ILE A 215
PHE A 217
 None
 0.99A 3j7zS-5ku1A:
undetectable
3j7za-5ku1A:
undetectable		 3j7zS-5ku1A:
13.70
3j7za-5ku1A:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		3 LYS A 461
ILE A 479
PHE A 483
 None
 0.93A 3j7zS-5mkfA:
undetectable
3j7za-5mkfA:
undetectable		 3j7zS-5mkfA:
7.93
3j7za-5mkfA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 3 LYS A 708
ILE A 119
PHE A 120
 None
 1.00A 3j7zS-5necA:
undetectable
3j7za-5necA:
undetectable		 3j7zS-5necA:
undetectable
3j7za-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 LYS A 677
ILE A 577
PHE A 576
 None
 0.96A 3j7zS-5t98A:
undetectable
3j7za-5t98A:
undetectable		 3j7zS-5t98A:
8.54
3j7za-5t98A:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		3 LYS A  14
ILE A 396
PHE A 399
 None
 0.75A 3j7zS-5v1sA:
undetectable
3j7za-5v1sA:
undetectable		 3j7zS-5v1sA:
13.33
3j7za-5v1sA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LYS A 340
ILE A  89
PHE A 135
 CSO  A  39 ( 2.6A)
None
None
 0.61A 3j7zS-5vm2A:
undetectable
3j7za-5vm2A:
undetectable		 3j7zS-5vm2A:
15.27
3j7za-5vm2A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 LYS C1141
ILE C1271
PHE C1270
 None
 0.86A 3j7zS-5y3rC:
undetectable
3j7za-5y3rC:
undetectable		 3j7zS-5y3rC:
2.56
3j7za-5y3rC:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 3 LYS A  19
ILE A 322
PHE A 317
 None
 0.96A 3j7zS-5ysmA:
undetectable
3j7za-5ysmA:
undetectable		 3j7zS-5ysmA:
undetectable
3j7za-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT

(Homo sapiens) 		no annotation 3 LYS A  91
ILE A 372
PHE A 376
 None
 0.77A 3j7zS-6au6A:
undetectable
3j7za-6au6A:
undetectable		 3j7zS-6au6A:
undetectable
3j7za-6au6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 3 LYS A1355
ILE A2162
PHE A2163
 None
 0.67A 3j7zS-6b3rA:
undetectable
3j7za-6b3rA:
undetectable		 3j7zS-6b3rA:
undetectable
3j7za-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 LYS M 369
ILE B  33
PHE B  49
 None
 0.84A 3j7zS-6ba5M:
undetectable
3j7za-6ba5M:
undetectable		 3j7zS-6ba5M:
undetectable
3j7za-6ba5M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 LYS A 308
ILE A 832
PHE A 834
 None
 0.83A 3j7zS-6bf6A:
undetectable
3j7za-6bf6A:
undetectable		 3j7zS-6bf6A:
undetectable
3j7za-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b TOXIN B

(Clostridioides
difficile) 		no annotation 3 LYS A1521
ILE A1624
PHE A1623
 None
 0.51A 3j7zS-6c0bA:
undetectable
3j7za-6c0bA:
undetectable		 3j7zS-6c0bA:
undetectable
3j7za-6c0bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		no annotation 3 LYS A 136
ILE A 236
PHE A 240
 None
 0.86A 3j7zS-6c8aA:
undetectable
3j7za-6c8aA:
undetectable		 3j7zS-6c8aA:
undetectable
3j7za-6c8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 3 LYS A 311
ILE A 198
PHE A 200
 None
 0.83A 3j7zS-6cxdA:
undetectable
3j7za-6cxdA:
undetectable		 3j7zS-6cxdA:
undetectable
3j7za-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6djw RBR-TYPE E3
UBIQUITIN
TRANSFERASE,RBR-TYPE
E3 UBIQUITIN
TRANSFERASE

(Bactrocera
dorsalis) 		no annotation 3 LYS A  71
ILE A 218
PHE A 239
 None
 0.97A 3j7zS-6djwA:
undetectable
3j7za-6djwA:
undetectable		 3j7zS-6djwA:
undetectable
3j7za-6djwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A2353
ILE A1823
PHE A1826
 None
 0.94A 3j7zS-6emkA:
undetectable
3j7za-6emkA:
undetectable		 3j7zS-6emkA:
undetectable
3j7za-6emkA:
undetectable