SIMILAR PATTERNS OF AMINO ACIDS FOR 3J6P_B_TA1B502_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cid | T CELL SURFACEGLYCOPROTEIN CD4 (Rattusnorvegicus) |
PF05790(C2-set)PF09191(CD4-extracel) | 5 | GLU A 101LEU A 163SER A 2GLY A 85LEU A 104 | None | 1.32A | 3j6pB-1cidA:undetectable | 3j6pB-1cidA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e25 | EXTENDED-SPECTRUMBETA-LACTAMASE PER-1 (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 5 | VAL A 263ASP A 246ARG A 273GLY A 223LEU A 224 | None | 1.08A | 3j6pB-1e25A:undetectable | 3j6pB-1e25A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpm | GMP SYNTHETASE (Escherichiacoli) |
PF00117(GATase)PF00958(GMP_synt_C)PF02540(NAD_synthase) | 5 | VAL A 122PHE A 83ARG A 199PRO A 182LEU A 194 | None | 1.27A | 3j6pB-1gpmA:2.0 | 3j6pB-1gpmA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kj9 | PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASE 2 (Escherichiacoli) |
PF02222(ATP-grasp) | 5 | VAL A 52LEU A 292ARG A 363GLY A 354LEU A 352 | NoneNone MG A 395 ( 4.9A)NoneNone | 1.26A | 3j6pB-1kj9A:0.0 | 3j6pB-1kj9A:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lw7 | TRANSCRIPTIONALREGULATOR NADR (Haemophilusinfluenzae) |
PF01467(CTP_transf_like)PF13521(AAA_28) | 5 | ASP A 99SER A 106PHE A 225ARG A 119PRO A 69 | None | 1.29A | 3j6pB-1lw7A:4.5 | 3j6pB-1lw7A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mbm | CHYMOTRYPSIN-LIKESERINE PROTEASE (Equinearteritis virus) |
PF05579(Peptidase_S32) | 5 | VAL A 133PHE A 60THR A 71GLY A 13LEU A 49 | None | 1.16A | 3j6pB-1mbmA:undetectable | 3j6pB-1mbmA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhs | PLASMA MEMBRANEATPASE (Neurosporacrassa) |
PF00122(E1-E2_ATPase)PF00690(Cation_ATPase_N)PF00702(Hydrolase) | 5 | VAL A 907ASP A 904GLU A 903ARG A 570LEU A 584 | None | 1.05A | 3j6pB-1mhsA:0.1 | 3j6pB-1mhsA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p1m | HYPOTHETICAL PROTEINTM0936 (Thermotogamaritima) |
PF01979(Amidohydro_1) | 5 | VAL A 112ASP A 113THR A 189GLY A 137LEU A 138 | NoneNoneNoneMET A5001 ( 3.8A)None | 1.31A | 3j6pB-1p1mA:0.1 | 3j6pB-1p1mA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlm | METHENYLTETRAHYDROMETHANOPTERINCYCLOHYDROLASE (Methanopyruskandleri) |
PF02289(MCH) | 5 | VAL A 159ASP A 160LEU A 167GLY A 32LEU A 29 | None | 1.25A | 3j6pB-1qlmA:undetectable | 3j6pB-1qlmA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uou | THYMIDINEPHOSPHORYLASE (Homo sapiens) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 5 | VAL A 427ASP A 426THR A 271GLY A 278LEU A 277 | None | 1.22A | 3j6pB-1uouA:undetectable | 3j6pB-1uouA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v40 | GLUTATHIONE-REQUIRING PROSTAGLANDIN DSYNTHASE (Homo sapiens) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 6THR A 7PRO A 47GLY A 49LEU A 46 | NoneNoneNoneGOL A3001 (-3.3A)None | 1.31A | 3j6pB-1v40A:undetectable | 3j6pB-1v40A:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybe | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Agrobacteriumtumefaciens) |
PF04095(NAPRTase) | 5 | VAL A 244LEU A 196PHE A 227GLY A 202LEU A 373 | None | 1.31A | 3j6pB-1ybeA:undetectable | 3j6pB-1ybeA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bfr | HYPOTHETICAL PROTEINAF1521 (Archaeoglobusfulgidus) |
PF01661(Macro) | 5 | VAL A 168LEU A 157PHE A 137THR A 155PRO A 123 | None | 1.18A | 3j6pB-2bfrA:2.4 | 3j6pB-2bfrA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bih | NITRATE REDUCTASE[NADPH] (Ogataea angusta) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | ASP A 53HIS A 233SER A 67THR A 136LEU A 74 | NoneMTV A1479 (-3.7A)NoneNoneNone | 1.18A | 3j6pB-2bihA:undetectable | 3j6pB-2bihA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bih | NITRATE REDUCTASE[NADPH] (Ogataea angusta) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | HIS A 233SER A 67THR A 136PRO A 69LEU A 74 | MTV A1479 (-3.7A)NoneNoneNoneNone | 1.26A | 3j6pB-2bihA:undetectable | 3j6pB-2bihA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dej | PROBABLEGALACTOKINASE (Pyrococcushorikoshii) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C)PF10509(GalKase_gal_bdg) | 5 | GLU A 137LEU A 300SER A 105GLY A 146LEU A 148 | APW A 402 ( 4.8A)NoneAPW A 402 (-2.2A)GLA A 401 (-3.4A)GLA A 401 ( 4.3A) | 1.21A | 3j6pB-2dejA:undetectable | 3j6pB-2dejA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fli | RIBULOSE-PHOSPHATE3-EPIMERASE (Streptococcuspyogenes) |
PF00834(Ribul_P_3_epim) | 5 | ASP A 176THR A 213PRO A 8GLY A 198LEU A 201 | DX5 A1901 ( 2.6A)NoneNoneDX5 A1901 (-3.4A)None | 1.06A | 3j6pB-2fliA:3.1 | 3j6pB-2fliA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fr1 | ERYTHROMYCINSYNTHASE, ERYAI (Saccharopolysporaerythraea) |
PF08659(KR) | 5 | ASP A1757SER A1773THR A1552PRO A1815GLY A1811 | None | 1.30A | 3j6pB-2fr1A:5.5 | 3j6pB-2fr1A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gjx | BETA-HEXOSAMINIDASEALPHA CHAIN (Homo sapiens) |
PF00728(Glyco_hydro_20)PF14845(Glycohydro_20b2) | 5 | VAL A 206ASP A 207PHE A 305THR A 297GLY A 261 | None | 1.06A | 3j6pB-2gjxA:undetectable | 3j6pB-2gjxA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk1 | BETA-HEXOSAMINIDASESUBUNIT ALPHA (Homo sapiens) |
no annotation | 5 | VAL I 206ASP I 207PHE I 305THR I 297GLY I 261 | NoneNGT A 21 (-3.8A)NoneNoneNone | 1.10A | 3j6pB-2gk1I:undetectable | 3j6pB-2gk1I:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ix2 | DNA POLYMERASESLIDING CLAMP B (Sulfolobussolfataricus) |
PF00705(PCNA_N) | 5 | VAL A 56ASP A 55LEU A 28SER A 237PHE A 15 | None | 1.31A | 3j6pB-2ix2A:undetectable | 3j6pB-2ix2A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jf4 | PERIPLASMICTREHALASE (Escherichiacoli) |
PF01204(Trehalase) | 5 | ASP A 160PHE A 407THR A 402PRO A 208GLY A 310 | VDM A1548 (-3.0A)NoneNoneNoneVDM A1548 (-3.7A) | 0.98A | 3j6pB-2jf4A:undetectable | 3j6pB-2jf4A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq0 | HYPOTHETICALCONSERVED PROTEINGK1056 (Geobacilluskaustophilus) |
PF08282(Hydrolase_3) | 5 | LEU A 23THR A 25ARG A 30GLY A 58LEU A 57 | None | 1.32A | 3j6pB-2pq0A:4.1 | 3j6pB-2pq0A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qmm | UPF0217 PROTEINAF_1056 (Archaeoglobusfulgidus) |
PF04013(Methyltrn_RNA_2) | 5 | VAL A 142ASP A 141ARG A 285PRO A 237LEU A 233 | None | 1.28A | 3j6pB-2qmmA:undetectable | 3j6pB-2qmmA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rcb | GLUTAMATE [NMDA]RECEPTOR SUBUNIT 3B (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 5 | ASP A 92PHE A 122ARG A 8GLY A 108LEU A 110 | NoneNoneGOL A 902 ( 4.1A)NoneNone | 1.29A | 3j6pB-2rcbA:undetectable | 3j6pB-2rcbA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsq | SURFACTIN SYNTHETASESUBUNIT 3 (Bacillussubtilis) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 5 | GLU A 446LEU A 388THR A 214PRO A 799GLY A 801 | None | 1.22A | 3j6pB-2vsqA:undetectable | 3j6pB-2vsqA:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wl1 | PYRIN (Homo sapiens) |
PF00622(SPRY)PF13765(PRY) | 5 | VAL A 587LEU A 709HIS A 739SER A 728THR A 707 | NoneNoneNoneNoneSCN A1778 ( 4.7A) | 1.14A | 3j6pB-2wl1A:undetectable | 3j6pB-2wl1A:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxg | DIHYDRODIPICOLINATESYNTHASE (Methanocaldococcusjannaschii) |
PF00701(DHDPS) | 5 | LEU A 142HIS A 117SER A 124GLY A 75LEU A 100 | None | 1.19A | 3j6pB-2yxgA:1.9 | 3j6pB-2yxgA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9j | XANTHINE OXIDASE (Bos taurus) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | VAL B 330LEU B 404THR B 373PRO B 410GLY B 296 | NoneFAD B 606 (-4.6A)NoneNoneNone | 1.29A | 3j6pB-3b9jB:undetectable | 3j6pB-3b9jB:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwv | DNA GYRASE, BSUBUNIT, TRUNCATED (Myxococcusxanthus) |
PF00204(DNA_gyraseB) | 5 | VAL A 271LEU A 183ARG A 260GLY A 265LEU A 322 | None | 1.26A | 3j6pB-3cwvA:undetectable | 3j6pB-3cwvA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecd | SERINEHYDROXYMETHYLTRANSFERASE 2 (Burkholderiapseudomallei) |
PF00464(SHMT) | 5 | VAL A 310LEU A 36THR A 369ARG A 366GLY A 316 | None | 1.32A | 3j6pB-3ecdA:undetectable | 3j6pB-3ecdA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4x | PHOSPHATIDYLINOSITOL-SPECIFICPHOSPHOLIPASE C1 (Streptomycesantibioticus) |
PF16670(PI-PLC-C1) | 5 | VAL A 74ASP A 62LEU A 153SER A 84LEU A 59 | None | 1.15A | 3j6pB-3h4xA:undetectable | 3j6pB-3h4xA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7v | O-SUCCINYLBENZOATESYNTHASE (Thermosynechococcuselongatus) |
PF13378(MR_MLE_C) | 5 | VAL A 137PHE A 179PRO A 196GLY A 168LEU A 197 | None | 1.29A | 3j6pB-3h7vA:undetectable | 3j6pB-3h7vA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3la8 | PUTATIVE PURINENUCLEOSIDEPHOSPHORYLASE (Streptococcusmutans) |
PF01048(PNP_UDP_1) | 5 | GLU A 23ARG A 98PRO A 22GLY A 104LEU A 103 | None | 1.04A | 3j6pB-3la8A:undetectable | 3j6pB-3la8A:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nn2 | CHLORITE DISMUTASE (Nitrospiradefluvii) |
PF06778(Chlor_dismutase) | 5 | ASP A 230PHE A 69ARG A 90GLY A 42LEU A 43 | GOL A 248 (-3.7A)NoneNoneNoneNone | 1.11A | 3j6pB-3nn2A:undetectable | 3j6pB-3nn2A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nn2 | CHLORITE DISMUTASE (Nitrospiradefluvii) |
PF06778(Chlor_dismutase) | 5 | ASP A 230SER A 55ARG A 90GLY A 42LEU A 43 | GOL A 248 (-3.7A)NoneNoneNoneNone | 0.78A | 3j6pB-3nn2A:undetectable | 3j6pB-3nn2A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ns1 | XANTHINEDEHYDROGENASE/OXIDASE (Bos taurus) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | VAL B 330LEU B 404THR B 373PRO B 410GLY B 296 | NoneFAD B 606 (-4.8A)NoneNoneNone | 1.30A | 3j6pB-3ns1B:undetectable | 3j6pB-3ns1B:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nze | PUTATIVETRANSCRIPTIONALREGULATOR,SUGAR-BINDING FAMILY (Paenarthrobacteraurescens) |
PF04198(Sugar-bind) | 5 | VAL A 247ASP A 243HIS A 269THR A 301GLY A 209 | None | 1.31A | 3j6pB-3nzeA:undetectable | 3j6pB-3nzeA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swg | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Aquifexaeolicus) |
PF00275(EPSP_synthase) | 5 | VAL A 118LEU A 43PHE A 39THR A 41LEU A 66 | None | 1.21A | 3j6pB-3swgA:undetectable | 3j6pB-3swgA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uen | DNA TOPOISOMERASE2-BINDING PROTEIN 1 (Homo sapiens) |
PF12738(PTCB-BRCT) | 5 | ASP A 648HIS A 694PRO A 645GLY A 672LEU A 671 | None | 1.29A | 3j6pB-3uenA:undetectable | 3j6pB-3uenA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7p | AMIDOHYDROLASEFAMILY PROTEIN (Nitratiruptorsp. SB155-2) |
PF01979(Amidohydro_1) | 5 | VAL A 256SER A 204THR A 113GLY A 307LEU A 62 | None | 1.23A | 3j6pB-3v7pA:2.8 | 3j6pB-3v7pA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | ASP A4352LEU A4644PRO A4289GLY A4291LEU A4290 | None | 1.32A | 3j6pB-3vkgA:undetectable | 3j6pB-3vkgA:9.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxo | CATALASE-PEROXIDASE (Synechococcuselongatus) |
PF00141(peroxidase) | 5 | VAL A 241ASP A 240LEU A 329PRO A 225GLY A 227 | NoneNoneNoneHEM A 801 ( 4.2A)None | 1.20A | 3j6pB-3wxoA:undetectable | 3j6pB-3wxoA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4av6 | K(+)-STIMULATEDPYROPHOSPHATE-ENERGIZED SODIUM PUMP (Thermotogamaritima) |
PF03030(H_PPase) | 5 | VAL A 440ASP A 432SER A 512GLY A 354LEU A 353 | None | 1.30A | 3j6pB-4av6A:undetectable | 3j6pB-4av6A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwp | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN-3 (Drosophilamelanogaster) |
no annotation | 5 | VAL A 647HIS A 540PHE A 563GLY A 597LEU A 599 | None | 1.23A | 3j6pB-4bwpA:undetectable | 3j6pB-4bwpA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci0 | F420-REDUCINGHYDROGENASE, SUBUNITALPHA (Methanothermobactermarburgensis) |
PF00374(NiFeSe_Hases) | 5 | GLU A 325LEU A 319SER A 212PHE A 222LEU A 348 | None | 1.02A | 3j6pB-4ci0A:undetectable | 3j6pB-4ci0A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dwq | TRNA-SPLICING LIGASERTCB (Pyrococcushorikoshii) |
PF01139(RtcB) | 5 | ASP A 65LEU A 5ARG A 27PRO A 73GLY A 76 | None | 1.02A | 3j6pB-4dwqA:undetectable | 3j6pB-4dwqA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eb5 | PROBABLE CYSTEINEDESULFURASE 2 (Archaeoglobusfulgidus) |
PF00266(Aminotran_5) | 5 | VAL A 101SER A 143ARG A 231GLY A 79LEU A 217 | None | 1.08A | 3j6pB-4eb5A:undetectable | 3j6pB-4eb5A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gi2 | CROTONYL-COACARBOXYLASE/REDUCTASE (Methylobacteriumextorquens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 306GLU A 308SER A 318PHE A 289GLY A 218 | NoneNoneNoneNoneNAP A 502 (-3.4A) | 1.27A | 3j6pB-4gi2A:undetectable | 3j6pB-4gi2A:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i59 | CYCLOHEXYLAMINEOXIDASE (Microbacteriumoxydans) |
PF01593(Amino_oxidase) | 5 | VAL A 156LEU A 200THR A 424GLY A 435LEU A 438 | None | 1.09A | 3j6pB-4i59A:undetectable | 3j6pB-4i59A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iuw | NEUTRALENDOPEPTIDASE (Lactobacillusrhamnosus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 5 | VAL A 173LEU A 405THR A 402GLY A 81LEU A 80 | None | 1.13A | 3j6pB-4iuwA:undetectable | 3j6pB-4iuwA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jpk | GERMLINE-TARGETINGHIV-1 GP120ENGINEERED OUTERDOMAIN, EOD-GT6 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | SER A 16PHE A 149THR A 146PRO A 11GLY A 103 | NAG A 201 (-4.9A)NoneNoneNoneNone | 1.29A | 3j6pB-4jpkA:undetectable | 3j6pB-4jpkA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kav | YHBX/YHJW/YIJP/YJDBFAMILY PROTEIN (Neisseriameningitidis) |
PF00884(Sulfatase) | 5 | VAL A 334LEU A 519PHE A 288THR A 517LEU A 236 | None | 1.29A | 3j6pB-4kavA:undetectable | 3j6pB-4kavA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m8n | PLEXINC1INTRACELLULAR REGION (Danio rerio) |
PF08337(Plexin_cytopl) | 5 | VAL A 593LEU A1023PRO A 740GLY A 738LEU A 741 | None | 1.27A | 3j6pB-4m8nA:undetectable | 3j6pB-4m8nA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4noi | DNA-DIRECTED RNAPOLYMERASE SUBUNITALPHA (Campylobacterjejuni) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L) | 5 | VAL A 121LEU A 169PHE A 141GLY A 113LEU A 130 | None | 1.06A | 3j6pB-4noiA:undetectable | 3j6pB-4noiA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oli | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 981GLU A 979LEU A 990ARG A 987GLY A1040 | 2TT A1202 (-3.7A)NoneNoneNone2TT A1202 (-3.4A) | 1.31A | 3j6pB-4oliA:undetectable | 3j6pB-4oliA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6b | EST-Y29 (metagenome) |
PF00144(Beta-lactamase) | 5 | LEU A 278PHE A 273PRO A 62GLY A 325LEU A 324 | None | 1.29A | 3j6pB-4p6bA:undetectable | 3j6pB-4p6bA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmi | CYTOSKELETON-ASSOCIATED PROTEIN 5 (Homo sapiens) |
PF12348(CLASP_N) | 5 | VAL A 949LEU A 881PRO A 945GLY A 943LEU A 942 | None | 1.20A | 3j6pB-4qmiA:undetectable | 3j6pB-4qmiA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v3d | ENDOTHELIAL PROTEINC RECEPTOR (Homo sapiens) |
PF16497(MHC_I_3) | 5 | LEU B 161SER B 17ARG B 156GLY B 78LEU B 79 | PTY B 200 (-4.4A)NoneNoneNonePTY B 200 ( 4.9A) | 0.99A | 3j6pB-4v3dB:undetectable | 3j6pB-4v3dB:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd1 | ACETOACETATE-COALIGASE (Streptomyceslividans) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 5 | LEU A 647PHE A 570ARG A 625PRO A 568GLY A 557 | None | 1.28A | 3j6pB-4wd1A:undetectable | 3j6pB-4wd1A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wis | LIPID SCRAMBLASE ([Nectria]haematococca) |
PF04547(Anoctamin) | 5 | VAL A 500ASP A 499LEU A 565SER A 184THR A 563 | None | 1.06A | 3j6pB-4wisA:undetectable | 3j6pB-4wisA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xq6 | DIHYDROOROTATEDEHYDROGENASE(QUINONE) (Mycobacteriumtuberculosis) |
PF01180(DHO_dh) | 5 | VAL A 53LEU A 275SER A 51GLY A 63LEU A 62 | None | 1.30A | 3j6pB-4xq6A:undetectable | 3j6pB-4xq6A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y1b | ANTE (Streptomycessp. NRRL 2288) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 298GLU A 300SER A 310PHE A 281GLY A 209 | NoneNoneNoneNoneNAP A 501 (-2.9A) | 1.29A | 3j6pB-4y1bA:2.7 | 3j6pB-4y1bA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zn2 | PSLG (Pseudomonasaeruginosa) |
PF00150(Cellulase) | 5 | LEU A 422SER A 435THR A 410PRO A 414GLY A 417 | None | 1.17A | 3j6pB-4zn2A:undetectable | 3j6pB-4zn2A:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cs4 | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF08326(ACC_central) | 5 | ASP A1269LEU A1075PRO A1273GLY A1266LEU A1087 | None | 1.29A | 3j6pB-5cs4A:undetectable | 3j6pB-5cs4A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d01 | N-ACETYL-ALPHA-D-GLUCOSAMINYL L-MALATESYNTHASE (Bacillussubtilis) |
PF00534(Glycos_transf_1)PF13439(Glyco_transf_4) | 5 | VAL A 288GLU A 283LEU A 232GLY A 301LEU A 279 | NoneGMT A 401 (-3.6A)NoneNoneNone | 1.16A | 3j6pB-5d01A:undetectable | 3j6pB-5d01A:24.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7g | IPT/TIGDOMAIN-CONTAININGPROTEIN BACOVA_02650 (Bacteroidesovatus) |
no annotation | 5 | VAL A 248LEU A 315SER A 246THR A 292PRO A 288 | None | 1.29A | 3j6pB-5e7gA:undetectable | 3j6pB-5e7gA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7h | IPT/TIGDOMAIN-CONTAININGPROTEIN BACOVA_02650 (Bacteroidesovatus) |
PF01833(TIG) | 5 | VAL A 248LEU A 315SER A 246THR A 292PRO A 288 | None | 1.27A | 3j6pB-5e7hA:undetectable | 3j6pB-5e7hA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e84 | 78 KDAGLUCOSE-REGULATEDPROTEIN (Homo sapiens) |
PF00012(HSP70) | 5 | VAL A 345ASP A 348SER A 233PRO A 421LEU A 422 | None | 1.31A | 3j6pB-5e84A:undetectable | 3j6pB-5e84A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ej0 | ENVELOPE PROTEIN H3 (Vaccinia virus) |
PF03213(Pox_P35) | 5 | VAL A 11HIS A 101PHE A 110THR A 194ARG A 227 | NoneNoneNonePG0 A 705 (-3.1A)EOH A 718 (-4.1A) | 1.32A | 3j6pB-5ej0A:undetectable | 3j6pB-5ej0A:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5es9 | LINEAR GRAMICIDINSYNTHETASE SUBUNIT A (Brevibacillusparabrevis) |
PF00501(AMP-binding)PF00550(PP-binding)PF00551(Formyl_trans_N)PF13193(AMP-binding_C) | 5 | LEU A 264HIS A 413SER A 438GLY A 409LEU A 406 | None | 1.32A | 3j6pB-5es9A:undetectable | 3j6pB-5es9A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h6b | PUTATIVE SECRETEDLIPASE (Streptomycessp. W007) |
PF01674(Lipase_2) | 5 | VAL A 202ASP A 200GLU A 231LEU A 77PHE A 153 | None | 1.23A | 3j6pB-5h6bA:4.3 | 3j6pB-5h6bA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hj7 | GLUTAMATE RACEMASE (Mycobacteriumtuberculosis) |
PF01177(Asp_Glu_race) | 5 | LEU A 250HIS A 187SER A 77ARG A 154PRO A 46 | NoneDGL A 301 ( 4.4A)DGL A 301 (-2.7A)NoneNone | 1.28A | 3j6pB-5hj7A:undetectable | 3j6pB-5hj7A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hm5 | TOPOISOMERASE V (Methanopyruskandleri) |
PF13412(HTH_24)PF14520(HHH_5) | 5 | GLU A 435LEU A 397ARG A 390GLY A 432LEU A 385 | None | 1.23A | 3j6pB-5hm5A:undetectable | 3j6pB-5hm5A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hsi | PUTATIVEDECARBOXYLASE (Lactobacillusbrevis) |
PF00282(Pyridoxal_deC) | 5 | VAL A 137GLU A 134HIS A 453THR A 103GLY A 401 | None | 1.18A | 3j6pB-5hsiA:undetectable | 3j6pB-5hsiA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5htp | PROBABLE SUGARKINASE (Synechococcuselongatus) |
PF02782(FGGY_C) | 5 | VAL A 255SER A 251THR A 354GLY A 275LEU A 247 | None | 1.02A | 3j6pB-5htpA:undetectable | 3j6pB-5htpA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyd | PROTEIN S100-Z (Homo sapiens) |
PF01023(S_100) | 5 | GLU A 69PHE A 16ARG A 40GLY A 32LEU A 34 | None | 1.30A | 3j6pB-5hydA:undetectable | 3j6pB-5hydA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5imy | VAGINOLYSIN (Gardnerellavaginalis) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 5 | VAL A 308GLU A 309SER A 197PHE A 240GLY A 314 | None | 1.21A | 3j6pB-5imyA:undetectable | 3j6pB-5imyA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jkn | PROTEIN FAM63A (Homo sapiens) |
PF04424(MINDY_DUB) | 5 | PHE A 229THR A 223PRO A 138GLY A 207LEU A 208 | None | 1.18A | 3j6pB-5jknA:undetectable | 3j6pB-5jknA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxl | FLAGELLAR HOOKPROTEIN FLGE (Campylobacterjejuni) |
PF00460(Flg_bb_rod)PF06429(Flg_bbr_C)PF07196(Flagellin_IN)PF07559(FlaE) | 5 | VAL A 422ASP A 499LEU A 489HIS A 425GLY A 470 | None | 1.06A | 3j6pB-5jxlA:undetectable | 3j6pB-5jxlA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ks8 | PYRUVATE CARBOXYLASESUBUNIT BETA (Methylobacillusflagellatus) |
PF00364(Biotin_lipoyl)PF00682(HMGL-like)PF02436(PYC_OADA) | 5 | LEU C 125SER C 105THR C 142GLY C 48LEU C 81 | NoneNoneNonePYR C2001 (-3.5A)PYR C2001 (-4.7A) | 1.20A | 3j6pB-5ks8C:2.6 | 3j6pB-5ks8C:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kx6 | GALACTOSIDE2-ALPHA-L-FUCOSYLTRANSFERASE (Arabidopsisthaliana) |
PF03254(XG_FTase) | 5 | ASP A 550GLU A 549SER A 517GLY A 554LEU A 555 | None | 1.22A | 3j6pB-5kx6A:undetectable | 3j6pB-5kx6A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2p | ARYLESTERASE (Sulfolobussolfataricus) |
PF07859(Abhydrolase_3) | 5 | ASP A 113GLU A 92HIS A 80GLY A 89LEU A 38 | None | 1.31A | 3j6pB-5l2pA:3.8 | 3j6pB-5l2pA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj6 | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN MACB (Aggregatibacteractinomycetemcomitans) |
no annotation | 5 | VAL A 420LEU A 387PRO A 415GLY A 417LEU A 416 | None | 1.15A | 3j6pB-5lj6A:undetectable | 3j6pB-5lj6A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lp4 | PENICILLIN-BINDINGPROTEIN 2 (PBP2) (Helicobacterpylori) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | VAL A 70GLU A 68LEU A 103THR A 102GLY A 280 | None | 1.26A | 3j6pB-5lp4A:undetectable | 3j6pB-5lp4A:21.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN BETA CHAIN (Schizosaccharomycespombe) |
no annotation | 5 | ASP A 26GLU A 27LEU A 215HIS A 227PRO A 357 | None | 0.98A | 3j6pB-5mjsA:53.7 | 3j6pB-5mjsA:59.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mjs | TUBULIN BETA CHAIN (Schizosaccharomycespombe) |
no annotation | 5 | ASP A 26LEU A 215HIS A 227PRO A 357LEU A 360 | None | 0.94A | 3j6pB-5mjsA:53.7 | 3j6pB-5mjsA:59.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 7 | GLU B 27LEU B 217PHE B 272THR B 276PRO B 360GLY B 370LEU B 371 | None | 1.22A | 3j6pB-5n5nB:54.0 | 3j6pB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 7 | GLU B 27SER B 236PHE B 272THR B 276PRO B 360GLY B 370LEU B 371 | None | 1.28A | 3j6pB-5n5nB:54.0 | 3j6pB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 5 | VAL B 23ASP B 26HIS B 229SER B 236THR B 276 | None | 1.23A | 3j6pB-5n5nB:54.0 | 3j6pB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 5 | VAL B 23ASP B 26LEU B 217HIS B 229THR B 276 | None | 1.09A | 3j6pB-5n5nB:54.0 | 3j6pB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 8 | VAL B 23GLU B 27HIS B 229SER B 236PHE B 272THR B 276PRO B 360GLY B 370 | None | 1.02A | 3j6pB-5n5nB:54.0 | 3j6pB-5n5nB:97.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 8 | VAL B 23GLU B 27LEU B 217HIS B 229PHE B 272THR B 276PRO B 360GLY B 370 | None | 0.92A | 3j6pB-5n5nB:54.0 | 3j6pB-5n5nB:97.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nbs | BETA-GLUCOSIDASE (Neurosporacrassa) |
no annotation | 5 | VAL A 543LEU A 454HIS A 545GLY A 417LEU A 476 | None | 1.26A | 3j6pB-5nbsA:undetectable | 3j6pB-5nbsA:9.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v1w | GLYCOSIDE HYDROLASE (Bacillushalodurans) |
PF03639(Glyco_hydro_81) | 5 | GLU A 480HIS A 713PHE A 773PRO A 356LEU A 355 | NoneEDO A 820 (-3.8A)NoneNoneNone | 1.20A | 3j6pB-5v1wA:undetectable | 3j6pB-5v1wA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v1w | GLYCOSIDE HYDROLASE (Bacillushalodurans) |
PF03639(Glyco_hydro_81) | 5 | GLU A 480PHE A 773PRO A 356GLY A 633LEU A 355 | None | 1.10A | 3j6pB-5v1wA:undetectable | 3j6pB-5v1wA:19.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 6 | ASP B 26LEU B 215THR B 274PRO B 358GLY B 360LEU B 361 | TA1 B 502 (-4.1A)NoneTA1 B 502 (-4.7A)NoneTA1 B 502 (-3.6A)TA1 B 502 (-3.7A) | 1.24A | 3j6pB-5w3jB:53.4 | 3j6pB-5w3jB:75.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 5 | ASP B 26SER B 234PRO B 358GLY B 360LEU B 361 | TA1 B 502 (-4.1A)TA1 B 502 ( 4.9A)NoneTA1 B 502 (-3.6A)TA1 B 502 (-3.7A) | 1.28A | 3j6pB-5w3jB:53.4 | 3j6pB-5w3jB:75.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 7 | VAL B 23ASP B 26GLU B 27LEU B 215THR B 274PRO B 358GLY B 360 | TA1 B 502 (-3.9A)TA1 B 502 (-4.1A)TA1 B 502 (-3.6A)NoneTA1 B 502 (-4.7A)NoneTA1 B 502 (-3.6A) | 0.79A | 3j6pB-5w3jB:53.4 | 3j6pB-5w3jB:75.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w3j | TUBULIN BETA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 6 | VAL B 23ASP B 26GLU B 27SER B 234PRO B 358GLY B 360 | TA1 B 502 (-3.9A)TA1 B 502 (-4.1A)TA1 B 502 (-3.6A)TA1 B 502 ( 4.9A)NoneTA1 B 502 (-3.6A) | 0.92A | 3j6pB-5w3jB:53.4 | 3j6pB-5w3jB:75.61 |