SIMILAR PATTERNS OF AMINO ACIDS FOR 3J6P_B_TA1B502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cid T CELL SURFACE
GLYCOPROTEIN CD4


(Rattus
norvegicus)
PF05790
(C2-set)
PF09191
(CD4-extracel)
5 GLU A 101
LEU A 163
SER A   2
GLY A  85
LEU A 104
None
1.32A 3j6pB-1cidA:
undetectable
3j6pB-1cidA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1


(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
5 VAL A 263
ASP A 246
ARG A 273
GLY A 223
LEU A 224
None
1.08A 3j6pB-1e25A:
undetectable
3j6pB-1e25A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli)
PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase)
5 VAL A 122
PHE A  83
ARG A 199
PRO A 182
LEU A 194
None
1.27A 3j6pB-1gpmA:
2.0
3j6pB-1gpmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2


(Escherichia
coli)
PF02222
(ATP-grasp)
5 VAL A  52
LEU A 292
ARG A 363
GLY A 354
LEU A 352
None
None
MG  A 395 ( 4.9A)
None
None
1.26A 3j6pB-1kj9A:
0.0
3j6pB-1kj9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR


(Haemophilus
influenzae)
PF01467
(CTP_transf_like)
PF13521
(AAA_28)
5 ASP A  99
SER A 106
PHE A 225
ARG A 119
PRO A  69
None
1.29A 3j6pB-1lw7A:
4.5
3j6pB-1lw7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE


(Equine
arteritis virus)
PF05579
(Peptidase_S32)
5 VAL A 133
PHE A  60
THR A  71
GLY A  13
LEU A  49
None
1.16A 3j6pB-1mbmA:
undetectable
3j6pB-1mbmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE


(Neurospora
crassa)
PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase)
5 VAL A 907
ASP A 904
GLU A 903
ARG A 570
LEU A 584
None
1.05A 3j6pB-1mhsA:
0.1
3j6pB-1mhsA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936


(Thermotoga
maritima)
PF01979
(Amidohydro_1)
5 VAL A 112
ASP A 113
THR A 189
GLY A 137
LEU A 138
None
None
None
MET  A5001 ( 3.8A)
None
1.31A 3j6pB-1p1mA:
0.1
3j6pB-1p1mA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE


(Methanopyrus
kandleri)
PF02289
(MCH)
5 VAL A 159
ASP A 160
LEU A 167
GLY A  32
LEU A  29
None
1.25A 3j6pB-1qlmA:
undetectable
3j6pB-1qlmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE


(Homo sapiens)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
5 VAL A 427
ASP A 426
THR A 271
GLY A 278
LEU A 277
None
1.22A 3j6pB-1uouA:
undetectable
3j6pB-1uouA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE


(Homo sapiens)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 LEU A   6
THR A   7
PRO A  47
GLY A  49
LEU A  46
None
None
None
GOL  A3001 (-3.3A)
None
1.31A 3j6pB-1v40A:
undetectable
3j6pB-1v40A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Agrobacterium
tumefaciens)
PF04095
(NAPRTase)
5 VAL A 244
LEU A 196
PHE A 227
GLY A 202
LEU A 373
None
1.31A 3j6pB-1ybeA:
undetectable
3j6pB-1ybeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521


(Archaeoglobus
fulgidus)
PF01661
(Macro)
5 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
None
1.18A 3j6pB-2bfrA:
2.4
3j6pB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]


(Ogataea angusta)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
5 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
None
MTV  A1479 (-3.7A)
None
None
None
1.18A 3j6pB-2bihA:
undetectable
3j6pB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]


(Ogataea angusta)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
5 HIS A 233
SER A  67
THR A 136
PRO A  69
LEU A  74
MTV  A1479 (-3.7A)
None
None
None
None
1.26A 3j6pB-2bihA:
undetectable
3j6pB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE


(Pyrococcus
horikoshii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
5 GLU A 137
LEU A 300
SER A 105
GLY A 146
LEU A 148
APW  A 402 ( 4.8A)
None
APW  A 402 (-2.2A)
GLA  A 401 (-3.4A)
GLA  A 401 ( 4.3A)
1.21A 3j6pB-2dejA:
undetectable
3j6pB-2dejA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fli RIBULOSE-PHOSPHATE
3-EPIMERASE


(Streptococcus
pyogenes)
PF00834
(Ribul_P_3_epim)
5 ASP A 176
THR A 213
PRO A   8
GLY A 198
LEU A 201
DX5  A1901 ( 2.6A)
None
None
DX5  A1901 (-3.4A)
None
1.06A 3j6pB-2fliA:
3.1
3j6pB-2fliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI


(Saccharopolyspora
erythraea)
PF08659
(KR)
5 ASP A1757
SER A1773
THR A1552
PRO A1815
GLY A1811
None
1.30A 3j6pB-2fr1A:
5.5
3j6pB-2fr1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN


(Homo sapiens)
PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
5 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
None
1.06A 3j6pB-2gjxA:
undetectable
3j6pB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA


(Homo sapiens)
no annotation 5 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
None
NGT  A  21 (-3.8A)
None
None
None
1.10A 3j6pB-2gk1I:
undetectable
3j6pB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B


(Sulfolobus
solfataricus)
PF00705
(PCNA_N)
5 VAL A  56
ASP A  55
LEU A  28
SER A 237
PHE A  15
None
1.31A 3j6pB-2ix2A:
undetectable
3j6pB-2ix2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE


(Escherichia
coli)
PF01204
(Trehalase)
5 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
0.98A 3j6pB-2jf4A:
undetectable
3j6pB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056


(Geobacillus
kaustophilus)
PF08282
(Hydrolase_3)
5 LEU A  23
THR A  25
ARG A  30
GLY A  58
LEU A  57
None
1.32A 3j6pB-2pq0A:
4.1
3j6pB-2pq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmm UPF0217 PROTEIN
AF_1056


(Archaeoglobus
fulgidus)
PF04013
(Methyltrn_RNA_2)
5 VAL A 142
ASP A 141
ARG A 285
PRO A 237
LEU A 233
None
1.28A 3j6pB-2qmmA:
undetectable
3j6pB-2qmmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B


(Rattus
norvegicus)
PF10613
(Lig_chan-Glu_bd)
5 ASP A  92
PHE A 122
ARG A   8
GLY A 108
LEU A 110
None
None
GOL  A 902 ( 4.1A)
None
None
1.29A 3j6pB-2rcbA:
undetectable
3j6pB-2rcbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
5 GLU A 446
LEU A 388
THR A 214
PRO A 799
GLY A 801
None
1.22A 3j6pB-2vsqA:
undetectable
3j6pB-2vsqA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens)
PF00622
(SPRY)
PF13765
(PRY)
5 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
None
None
None
None
SCN  A1778 ( 4.7A)
1.14A 3j6pB-2wl1A:
undetectable
3j6pB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxg DIHYDRODIPICOLINATE
SYNTHASE


(Methanocaldococcus
jannaschii)
PF00701
(DHDPS)
5 LEU A 142
HIS A 117
SER A 124
GLY A  75
LEU A 100
None
1.19A 3j6pB-2yxgA:
1.9
3j6pB-2yxgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
5 VAL B 330
LEU B 404
THR B 373
PRO B 410
GLY B 296
None
FAD  B 606 (-4.6A)
None
None
None
1.29A 3j6pB-3b9jB:
undetectable
3j6pB-3b9jB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED


(Myxococcus
xanthus)
PF00204
(DNA_gyraseB)
5 VAL A 271
LEU A 183
ARG A 260
GLY A 265
LEU A 322
None
1.26A 3j6pB-3cwvA:
undetectable
3j6pB-3cwvA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2


(Burkholderia
pseudomallei)
PF00464
(SHMT)
5 VAL A 310
LEU A  36
THR A 369
ARG A 366
GLY A 316
None
1.32A 3j6pB-3ecdA:
undetectable
3j6pB-3ecdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1


(Streptomyces
antibioticus)
PF16670
(PI-PLC-C1)
5 VAL A  74
ASP A  62
LEU A 153
SER A  84
LEU A  59
None
1.15A 3j6pB-3h4xA:
undetectable
3j6pB-3h4xA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7v O-SUCCINYLBENZOATE
SYNTHASE


(Thermosynechococcus
elongatus)
PF13378
(MR_MLE_C)
5 VAL A 137
PHE A 179
PRO A 196
GLY A 168
LEU A 197
None
1.29A 3j6pB-3h7vA:
undetectable
3j6pB-3h7vA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE


(Streptococcus
mutans)
PF01048
(PNP_UDP_1)
5 GLU A  23
ARG A  98
PRO A  22
GLY A 104
LEU A 103
None
1.04A 3j6pB-3la8A:
undetectable
3j6pB-3la8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nn2 CHLORITE DISMUTASE

(Nitrospira
defluvii)
PF06778
(Chlor_dismutase)
5 ASP A 230
PHE A  69
ARG A  90
GLY A  42
LEU A  43
GOL  A 248 (-3.7A)
None
None
None
None
1.11A 3j6pB-3nn2A:
undetectable
3j6pB-3nn2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nn2 CHLORITE DISMUTASE

(Nitrospira
defluvii)
PF06778
(Chlor_dismutase)
5 ASP A 230
SER A  55
ARG A  90
GLY A  42
LEU A  43
GOL  A 248 (-3.7A)
None
None
None
None
0.78A 3j6pB-3nn2A:
undetectable
3j6pB-3nn2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E


(Bos taurus)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
5 VAL B 330
LEU B 404
THR B 373
PRO B 410
GLY B 296
None
FAD  B 606 (-4.8A)
None
None
None
1.30A 3j6pB-3ns1B:
undetectable
3j6pB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY


(Paenarthrobacter
aurescens)
PF04198
(Sugar-bind)
5 VAL A 247
ASP A 243
HIS A 269
THR A 301
GLY A 209
None
1.31A 3j6pB-3nzeA:
undetectable
3j6pB-3nzeA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Aquifex
aeolicus)
PF00275
(EPSP_synthase)
5 VAL A 118
LEU A  43
PHE A  39
THR A  41
LEU A  66
None
1.21A 3j6pB-3swgA:
undetectable
3j6pB-3swgA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uen DNA TOPOISOMERASE
2-BINDING PROTEIN 1


(Homo sapiens)
PF12738
(PTCB-BRCT)
5 ASP A 648
HIS A 694
PRO A 645
GLY A 672
LEU A 671
None
1.29A 3j6pB-3uenA:
undetectable
3j6pB-3uenA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN


(Nitratiruptor
sp. SB155-2)
PF01979
(Amidohydro_1)
5 VAL A 256
SER A 204
THR A 113
GLY A 307
LEU A  62
None
1.23A 3j6pB-3v7pA:
2.8
3j6pB-3v7pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 ASP A4352
LEU A4644
PRO A4289
GLY A4291
LEU A4290
None
1.32A 3j6pB-3vkgA:
undetectable
3j6pB-3vkgA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus)
PF00141
(peroxidase)
5 VAL A 241
ASP A 240
LEU A 329
PRO A 225
GLY A 227
None
None
None
HEM  A 801 ( 4.2A)
None
1.20A 3j6pB-3wxoA:
undetectable
3j6pB-3wxoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
5 VAL A 440
ASP A 432
SER A 512
GLY A 354
LEU A 353
None
1.30A 3j6pB-4av6A:
undetectable
3j6pB-4av6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3


(Drosophila
melanogaster)
no annotation 5 VAL A 647
HIS A 540
PHE A 563
GLY A 597
LEU A 599
None
1.23A 3j6pB-4bwpA:
undetectable
3j6pB-4bwpA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA


(Methanothermobacter
marburgensis)
PF00374
(NiFeSe_Hases)
5 GLU A 325
LEU A 319
SER A 212
PHE A 222
LEU A 348
None
1.02A 3j6pB-4ci0A:
undetectable
3j6pB-4ci0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB


(Pyrococcus
horikoshii)
PF01139
(RtcB)
5 ASP A  65
LEU A   5
ARG A  27
PRO A  73
GLY A  76
None
1.02A 3j6pB-4dwqA:
undetectable
3j6pB-4dwqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2


(Archaeoglobus
fulgidus)
PF00266
(Aminotran_5)
5 VAL A 101
SER A 143
ARG A 231
GLY A  79
LEU A 217
None
1.08A 3j6pB-4eb5A:
undetectable
3j6pB-4eb5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E


(Methylobacterium
extorquens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 VAL A 306
GLU A 308
SER A 318
PHE A 289
GLY A 218
None
None
None
None
NAP  A 502 (-3.4A)
1.27A 3j6pB-4gi2A:
undetectable
3j6pB-4gi2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE


(Microbacterium
oxydans)
PF01593
(Amino_oxidase)
5 VAL A 156
LEU A 200
THR A 424
GLY A 435
LEU A 438
None
1.09A 3j6pB-4i59A:
undetectable
3j6pB-4i59A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE


(Lactobacillus
rhamnosus)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
5 VAL A 173
LEU A 405
THR A 402
GLY A  81
LEU A  80
None
1.13A 3j6pB-4iuwA:
undetectable
3j6pB-4iuwA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 SER A  16
PHE A 149
THR A 146
PRO A  11
GLY A 103
NAG  A 201 (-4.9A)
None
None
None
None
1.29A 3j6pB-4jpkA:
undetectable
3j6pB-4jpkA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN


(Neisseria
meningitidis)
PF00884
(Sulfatase)
5 VAL A 334
LEU A 519
PHE A 288
THR A 517
LEU A 236
None
1.29A 3j6pB-4kavA:
undetectable
3j6pB-4kavA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION


(Danio rerio)
PF08337
(Plexin_cytopl)
5 VAL A 593
LEU A1023
PRO A 740
GLY A 738
LEU A 741
None
1.27A 3j6pB-4m8nA:
undetectable
3j6pB-4m8nA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA


(Campylobacter
jejuni)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
5 VAL A 121
LEU A 169
PHE A 141
GLY A 113
LEU A 130
None
1.06A 3j6pB-4noiA:
undetectable
3j6pB-4noiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 981
GLU A 979
LEU A 990
ARG A 987
GLY A1040
2TT  A1202 (-3.7A)
None
None
None
2TT  A1202 (-3.4A)
1.31A 3j6pB-4oliA:
undetectable
3j6pB-4oliA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome)
PF00144
(Beta-lactamase)
5 LEU A 278
PHE A 273
PRO A  62
GLY A 325
LEU A 324
None
1.29A 3j6pB-4p6bA:
undetectable
3j6pB-4p6bA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmi CYTOSKELETON-ASSOCIA
TED PROTEIN 5


(Homo sapiens)
PF12348
(CLASP_N)
5 VAL A 949
LEU A 881
PRO A 945
GLY A 943
LEU A 942
None
1.20A 3j6pB-4qmiA:
undetectable
3j6pB-4qmiA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3d ENDOTHELIAL PROTEIN
C RECEPTOR


(Homo sapiens)
PF16497
(MHC_I_3)
5 LEU B 161
SER B  17
ARG B 156
GLY B  78
LEU B  79
PTY  B 200 (-4.4A)
None
None
None
PTY  B 200 ( 4.9A)
0.99A 3j6pB-4v3dB:
undetectable
3j6pB-4v3dB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE


(Streptomyces
lividans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
5 LEU A 647
PHE A 570
ARG A 625
PRO A 568
GLY A 557
None
1.28A 3j6pB-4wd1A:
undetectable
3j6pB-4wd1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca)
PF04547
(Anoctamin)
5 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.06A 3j6pB-4wisA:
undetectable
3j6pB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)


(Mycobacterium
tuberculosis)
PF01180
(DHO_dh)
5 VAL A  53
LEU A 275
SER A  51
GLY A  63
LEU A  62
None
1.30A 3j6pB-4xq6A:
undetectable
3j6pB-4xq6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 VAL A 298
GLU A 300
SER A 310
PHE A 281
GLY A 209
None
None
None
None
NAP  A 501 (-2.9A)
1.29A 3j6pB-4y1bA:
2.7
3j6pB-4y1bA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn2 PSLG

(Pseudomonas
aeruginosa)
PF00150
(Cellulase)
5 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
None
1.17A 3j6pB-4zn2A:
undetectable
3j6pB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF08326
(ACC_central)
5 ASP A1269
LEU A1075
PRO A1273
GLY A1266
LEU A1087
None
1.29A 3j6pB-5cs4A:
undetectable
3j6pB-5cs4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE


(Bacillus
subtilis)
PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4)
5 VAL A 288
GLU A 283
LEU A 232
GLY A 301
LEU A 279
None
GMT  A 401 (-3.6A)
None
None
None
1.16A 3j6pB-5d01A:
undetectable
3j6pB-5d01A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650


(Bacteroides
ovatus)
no annotation 5 VAL A 248
LEU A 315
SER A 246
THR A 292
PRO A 288
None
1.29A 3j6pB-5e7gA:
undetectable
3j6pB-5e7gA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650


(Bacteroides
ovatus)
PF01833
(TIG)
5 VAL A 248
LEU A 315
SER A 246
THR A 292
PRO A 288
None
1.27A 3j6pB-5e7hA:
undetectable
3j6pB-5e7hA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN


(Homo sapiens)
PF00012
(HSP70)
5 VAL A 345
ASP A 348
SER A 233
PRO A 421
LEU A 422
None
1.31A 3j6pB-5e84A:
undetectable
3j6pB-5e84A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej0 ENVELOPE PROTEIN H3

(Vaccinia virus)
PF03213
(Pox_P35)
5 VAL A  11
HIS A 101
PHE A 110
THR A 194
ARG A 227
None
None
None
PG0  A 705 (-3.1A)
EOH  A 718 (-4.1A)
1.32A 3j6pB-5ej0A:
undetectable
3j6pB-5ej0A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A


(Brevibacillus
parabrevis)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C)
5 LEU A 264
HIS A 413
SER A 438
GLY A 409
LEU A 406
None
1.32A 3j6pB-5es9A:
undetectable
3j6pB-5es9A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE


(Streptomyces
sp. W007)
PF01674
(Lipase_2)
5 VAL A 202
ASP A 200
GLU A 231
LEU A  77
PHE A 153
None
1.23A 3j6pB-5h6bA:
4.3
3j6pB-5h6bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis)
PF01177
(Asp_Glu_race)
5 LEU A 250
HIS A 187
SER A  77
ARG A 154
PRO A  46
None
DGL  A 301 ( 4.4A)
DGL  A 301 (-2.7A)
None
None
1.28A 3j6pB-5hj7A:
undetectable
3j6pB-5hj7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri)
PF13412
(HTH_24)
PF14520
(HHH_5)
5 GLU A 435
LEU A 397
ARG A 390
GLY A 432
LEU A 385
None
1.23A 3j6pB-5hm5A:
undetectable
3j6pB-5hm5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE


(Lactobacillus
brevis)
PF00282
(Pyridoxal_deC)
5 VAL A 137
GLU A 134
HIS A 453
THR A 103
GLY A 401
None
1.18A 3j6pB-5hsiA:
undetectable
3j6pB-5hsiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE


(Synechococcus
elongatus)
PF02782
(FGGY_C)
5 VAL A 255
SER A 251
THR A 354
GLY A 275
LEU A 247
None
1.02A 3j6pB-5htpA:
undetectable
3j6pB-5htpA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyd PROTEIN S100-Z

(Homo sapiens)
PF01023
(S_100)
5 GLU A  69
PHE A  16
ARG A  40
GLY A  32
LEU A  34
None
1.30A 3j6pB-5hydA:
undetectable
3j6pB-5hydA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
5 VAL A 308
GLU A 309
SER A 197
PHE A 240
GLY A 314
None
1.21A 3j6pB-5imyA:
undetectable
3j6pB-5imyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkn PROTEIN FAM63A

(Homo sapiens)
PF04424
(MINDY_DUB)
5 PHE A 229
THR A 223
PRO A 138
GLY A 207
LEU A 208
None
1.18A 3j6pB-5jknA:
undetectable
3j6pB-5jknA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE


(Campylobacter
jejuni)
PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE)
5 VAL A 422
ASP A 499
LEU A 489
HIS A 425
GLY A 470
None
1.06A 3j6pB-5jxlA:
undetectable
3j6pB-5jxlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA


(Methylobacillus
flagellatus)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
5 LEU C 125
SER C 105
THR C 142
GLY C  48
LEU C  81
None
None
None
PYR  C2001 (-3.5A)
PYR  C2001 (-4.7A)
1.20A 3j6pB-5ks8C:
2.6
3j6pB-5ks8C:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE


(Arabidopsis
thaliana)
PF03254
(XG_FTase)
5 ASP A 550
GLU A 549
SER A 517
GLY A 554
LEU A 555
None
1.22A 3j6pB-5kx6A:
undetectable
3j6pB-5kx6A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus)
PF07859
(Abhydrolase_3)
5 ASP A 113
GLU A  92
HIS A  80
GLY A  89
LEU A  38
None
1.31A 3j6pB-5l2pA:
3.8
3j6pB-5l2pA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Aggregatibacter
actinomycetemcomitans)
no annotation 5 VAL A 420
LEU A 387
PRO A 415
GLY A 417
LEU A 416
None
1.15A 3j6pB-5lj6A:
undetectable
3j6pB-5lj6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)


(Helicobacter
pylori)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 VAL A  70
GLU A  68
LEU A 103
THR A 102
GLY A 280
None
1.26A 3j6pB-5lp4A:
undetectable
3j6pB-5lp4A:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe)
no annotation 5 ASP A  26
GLU A  27
LEU A 215
HIS A 227
PRO A 357
None
0.98A 3j6pB-5mjsA:
53.7
3j6pB-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe)
no annotation 5 ASP A  26
LEU A 215
HIS A 227
PRO A 357
LEU A 360
None
0.94A 3j6pB-5mjsA:
53.7
3j6pB-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 7 GLU B  27
LEU B 217
PHE B 272
THR B 276
PRO B 360
GLY B 370
LEU B 371
None
1.22A 3j6pB-5n5nB:
54.0
3j6pB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 7 GLU B  27
SER B 236
PHE B 272
THR B 276
PRO B 360
GLY B 370
LEU B 371
None
1.28A 3j6pB-5n5nB:
54.0
3j6pB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 5 VAL B  23
ASP B  26
HIS B 229
SER B 236
THR B 276
None
1.23A 3j6pB-5n5nB:
54.0
3j6pB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 5 VAL B  23
ASP B  26
LEU B 217
HIS B 229
THR B 276
None
1.09A 3j6pB-5n5nB:
54.0
3j6pB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 8 VAL B  23
GLU B  27
HIS B 229
SER B 236
PHE B 272
THR B 276
PRO B 360
GLY B 370
None
1.02A 3j6pB-5n5nB:
54.0
3j6pB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 8 VAL B  23
GLU B  27
LEU B 217
HIS B 229
PHE B 272
THR B 276
PRO B 360
GLY B 370
None
0.92A 3j6pB-5n5nB:
54.0
3j6pB-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa)
no annotation 5 VAL A 543
LEU A 454
HIS A 545
GLY A 417
LEU A 476
None
1.26A 3j6pB-5nbsA:
undetectable
3j6pB-5nbsA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans)
PF03639
(Glyco_hydro_81)
5 GLU A 480
HIS A 713
PHE A 773
PRO A 356
LEU A 355
None
EDO  A 820 (-3.8A)
None
None
None
1.20A 3j6pB-5v1wA:
undetectable
3j6pB-5v1wA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans)
PF03639
(Glyco_hydro_81)
5 GLU A 480
PHE A 773
PRO A 356
GLY A 633
LEU A 355
None
1.10A 3j6pB-5v1wA:
undetectable
3j6pB-5v1wA:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
6 ASP B  26
LEU B 215
THR B 274
PRO B 358
GLY B 360
LEU B 361
TA1  B 502 (-4.1A)
None
TA1  B 502 (-4.7A)
None
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
1.24A 3j6pB-5w3jB:
53.4
3j6pB-5w3jB:
75.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 ASP B  26
SER B 234
PRO B 358
GLY B 360
LEU B 361
TA1  B 502 (-4.1A)
TA1  B 502 ( 4.9A)
None
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
1.28A 3j6pB-5w3jB:
53.4
3j6pB-5w3jB:
75.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
7 VAL B  23
ASP B  26
GLU B  27
LEU B 215
THR B 274
PRO B 358
GLY B 360
TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 (-4.7A)
None
TA1  B 502 (-3.6A)
0.79A 3j6pB-5w3jB:
53.4
3j6pB-5w3jB:
75.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
6 VAL B  23
ASP B  26
GLU B  27
SER B 234
PRO B 358
GLY B 360
TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.9A)
None
TA1  B 502 (-3.6A)
0.92A 3j6pB-5w3jB:
53.4
3j6pB-5w3jB:
75.61