SIMILAR PATTERNS OF AMINO ACIDS FOR 3J6G_J_TA1J502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gJ-1crkA:
undetectable		 3j6gJ-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gJ-1ehiA:
undetectable		 3j6gJ-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1f INTERLEUKIN-19

(Homo sapiens) 		PF00726
(IL10) 		5 VAL A  71
ASP A  74
LEU A  63
SER A 138
THR A 116
 None
 1.37A 3j6gJ-1n1fA:
undetectable		 3j6gJ-1n1fA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gJ-1qk1A:
undetectable		 3j6gJ-1qk1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1j DNA EXCISION REPAIR
PROTEIN ERCC-1

(Homo sapiens) 		PF14520
(HHH_5) 		5 VAL B 288
ASP B 287
LEU B 260
THR B 256
LEU B 277
 None
None
None
None
HG  B   1 ( 3.8A)
 1.24A 3j6gJ-2a1jB:
undetectable		 3j6gJ-2a1jB:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gJ-2bihA:
undetectable		 3j6gJ-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		5 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.46A 3j6gJ-2eaaA:
undetectable		 3j6gJ-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kp6 UNCHARACTERIZED
PROTEIN

(Chromobacterium
violaceum) 		PF10982
(DUF2789) 		5 LEU A  33
SER A  30
PHE A  44
GLN A  14
LEU A  17
 None
 1.39A 3j6gJ-2kp6A:
undetectable		 3j6gJ-2kp6A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2

(Gallus gallus) 		PF01115
(F_actin_cap_B)
PF01267
(F-actin_cap_A) 		5 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gJ-2kxpB:
undetectable		 3j6gJ-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 ASP A 264
LEU A 258
SER A 151
THR A 245
LEU A 144
 None
 1.41A 3j6gJ-2q83A:
undetectable		 3j6gJ-2q83A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 262
ASP A 241
HIS A 250
THR A 273
LEU A 307
 None
 1.42A 3j6gJ-2qddA:
1.5		 3j6gJ-2qddA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
 None
 1.41A 3j6gJ-2yr0A:
undetectable		 3j6gJ-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		5 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gJ-3axiA:
2.1		 3j6gJ-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371

(Escherichia
coli;
Homo sapiens) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 ASP A1275
LEU A1258
PHE A1257
THR A1252
LEU A1215
 None
None
None
B44  A   1 (-3.6A)
None
 1.38A 3j6gJ-3gd7A:
undetectable		 3j6gJ-3gd7A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 ASP A  14
LEU A 136
SER A 139
PHE A 125
THR A  48
 None
 1.49A 3j6gJ-3j97A:
1.8		 3j6gJ-3j97A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3n PHD FINGER PROTEIN 8

(Homo sapiens) 		PF02373
(JmjC) 		5 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gJ-3k3nA:
undetectable		 3j6gJ-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		5 VAL A 253
ASP A 255
PHE A 181
THR A 242
LEU A 197
 None
 1.07A 3j6gJ-3l5aA:
undetectable		 3j6gJ-3l5aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdm COAT PROTEIN

(Hibiscus latent
Singapore virus) 		PF00721
(TMV_coat) 		5 VAL P  22
ASP P  21
SER P  51
PHE P  80
THR P  75
 None
 1.43A 3j6gJ-3pdmP:
undetectable		 3j6gJ-3pdmP:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		5 VAL A 221
ASP A 222
LEU A  19
THR A  45
LEU A 247
 None
 1.23A 3j6gJ-3qfoA:
undetectable		 3j6gJ-3qfoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE

(Mycobacteroides
abscessus) 		PF00557
(Peptidase_M24) 		5 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gJ-3tavA:
undetectable		 3j6gJ-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 VAL A 146
ASP A 145
PHE A  87
ARG A 220
LEU A 237
 None
 1.34A 3j6gJ-3vomA:
undetectable		 3j6gJ-3vomA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 VAL A 102
ASP A 100
LEU A 167
PHE A 147
ARG A 200
 None
None
None
BGC  A 605 (-4.7A)
BGC  A 605 (-3.0A)
 1.50A 3j6gJ-3wy2A:
undetectable		 3j6gJ-3wy2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 VAL A 202
ASP A 203
SER A 199
ARG A 911
LEU A 838
 None
 1.44A 3j6gJ-3zusA:
undetectable		 3j6gJ-3zusA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 VAL A 183
LEU A 135
PHE A 132
GLN A  96
LEU A 143
 None
 1.23A 3j6gJ-3zynA:
undetectable		 3j6gJ-3zynA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 ASP A 312
LEU A  49
THR A 259
ARG A 347
LEU A 277
 None
 1.06A 3j6gJ-4evqA:
2.8		 3j6gJ-4evqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew9 PECTATE LYASE

(Caldicellulosiruptor
bescii) 		PF03211
(Pectate_lyase) 		5 VAL A  82
ASP A  81
LEU A 131
PHE A 123
THR A 150
 CA  A 201 (-4.9A)
CA  A 201 (-3.0A)
None
None
None
 1.29A 3j6gJ-4ew9A:
undetectable		 3j6gJ-4ew9A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		5 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gJ-4f0tB:
undetectable		 3j6gJ-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.24A 3j6gJ-4fm9A:
4.1		 3j6gJ-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gJ-4gzuA:
undetectable		 3j6gJ-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 11
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2) 		5 LEU K  42
SER K   7
PHE K  45
THR N 158
LEU N 171
 None
 1.33A 3j6gJ-4heaK:
undetectable		 3j6gJ-4heaK:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gJ-4imvA:
undetectable		 3j6gJ-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB

(Salmonella
enterica) 		PF03466
(LysR_substrate) 		5 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gJ-4lp2B:
undetectable		 3j6gJ-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3a ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.20A 3j6gJ-4u3aA:
undetectable		 3j6gJ-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN

(Mus musculus) 		PF00715
(IL2)
PF07654
(C1-set)
PF07686
(V-set) 		5 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gJ-4yueC:
undetectable		 3j6gJ-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF02358
(Trehalose_PPase) 		5 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gJ-5gvxA:
undetectable		 3j6gJ-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.38A 3j6gJ-5gxuA:
5.5		 3j6gJ-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ASP A 110
SER A 144
THR A 405
GLN A 413
LEU A  99
 None
 1.49A 3j6gJ-5hwqA:
undetectable		 3j6gJ-5hwqA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 VAL B 203
ASP B 202
LEU B 191
THR B  54
GLN B 345
 None
None
None
ADP  B 502 (-4.1A)
None
 1.50A 3j6gJ-5lb3B:
1.9		 3j6gJ-5lb3B:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		5 HIS A 993
LEU A 992
SER A 984
THR A 740
GLN A1168
 None
 1.42A 3j6gJ-5mzaA:
undetectable		 3j6gJ-5mzaA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
HIS B 229
LEU B 230
PHE B 272
THR B 276
GLN B 281
 None
 1.01A 3j6gJ-5n5nB:
57.1		 3j6gJ-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
HIS B 229
SER B 236
PHE B 272
THR B 276
GLN B 281
 None
 1.03A 3j6gJ-5n5nB:
57.1		 3j6gJ-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
LEU B 230
PHE B 272
THR B 276
GLN B 281
LEU B 371
 None
 1.07A 3j6gJ-5n5nB:
57.1		 3j6gJ-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
SER B 236
PHE B 272
THR B 276
GLN B 281
LEU B 371
 None
 1.10A 3j6gJ-5n5nB:
57.1		 3j6gJ-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomyces
pombe) 		PF08638
(Med14) 		5 VAL A 368
HIS A 370
LEU A 359
PHE A 331
THR A 334
 None
 1.44A 3j6gJ-5n9jA:
undetectable		 3j6gJ-5n9jA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
LEU B 228
THR B 274
GLN B 279
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
TA1  B 502 (-4.7A)
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.7A)
 1.03A 3j6gJ-5w3jB:
56.6		 3j6gJ-5w3jB:
77.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
SER B 230
GLN B 279
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.7A)
 1.40A 3j6gJ-5w3jB:
56.6		 3j6gJ-5w3jB:
77.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
SER B 234
GLN B 279
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 ( 4.9A)
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.7A)
 1.19A 3j6gJ-5w3jB:
56.6		 3j6gJ-5w3jB:
77.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 HIS A 243
LEU A 242
GLN A 255
ARG A 346
LEU A 345
 None
 1.12A 3j6gJ-6byiA:
undetectable		 3j6gJ-6byiA:
undetectable