SIMILAR PATTERNS OF AMINO ACIDS FOR 3IWM_G_010G6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 THR A 234
LEU A 250
MET A 275
ASN A 254
 None
 1.21A 3iwmC-2cvtA:
0.0		 3iwmC-2cvtA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzi TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Shewanella
loihica) 		PF00440
(TetR_N) 		4 THR A  97
LEU A  79
MET A 170
ASN A 140
 None
EDO  A 223 ( 4.6A)
UNL  A 218 (-4.2A)
UNL  A 218 (-4.1A)
 1.46A 3iwmC-3gziA:
undetectable		 3iwmC-3gziA:
19.87