SIMILAR PATTERNS OF AMINO ACIDS FOR 3IV6_C_SAMC301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		3 SER A 274
ASP A 276
ASP A 264
 None
 0.80A 3iv6C-1c8oA:
undetectable		 3iv6C-1c8oA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		3 SER A  76
ASP A  65
ASP A  82
 None
 0.73A 3iv6C-1dp2A:
undetectable		 3iv6C-1dp2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN

(Clostridium
botulinum;
Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF01742
(Peptidase_M27) 		3 SER B 294
ASP B 291
ASP A 123
 None
 0.82A 3iv6C-1e1hB:
undetectable		 3iv6C-1e1hB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0i INOSITOL
MONOPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF00459
(Inositol_P) 		3 SER A 241
ASP A 188
ASP A 246
 None
 0.92A 3iv6C-1g0iA:
undetectable		 3iv6C-1g0iA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g33 PARVALBUMIN ALPHA

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		3 SER A  65
ASP A  76
ASP A  61
 None
 0.67A 3iv6C-1g33A:
undetectable		 3iv6C-1g33A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhn CALNEXIN

(Canis lupus) 		PF00262
(Calreticulin) 		3 SER A  67
ASP A 454
ASP A 444
 None
 0.94A 3iv6C-1jhnA:
undetectable		 3iv6C-1jhnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no5 HYPOTHETICAL PROTEIN
HI0073

(Haemophilus
influenzae) 		PF01909
(NTP_transf_2) 		3 SER A  35
ASP A  48
ASP A   8
 ZN  A 501 ( 4.2A)
ZN  A 501 ( 2.6A)
None
 0.74A 3iv6C-1no5A:
undetectable		 3iv6C-1no5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii) 		PF00331
(Glyco_hydro_10) 		3 SER A 121
ASP A 123
ASP A 230
 None
 0.80A 3iv6C-1nq6A:
undetectable		 3iv6C-1nq6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		3 SER A 245
ASP A 312
ASP A 251
 None
 0.91A 3iv6C-1oywA:
2.8		 3iv6C-1oywA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		3 SER A 120
ASP A  93
ASP A  98
 None
 0.80A 3iv6C-1pxzA:
undetectable		 3iv6C-1pxzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1) 		3 SER D 153
ASP D  21
ASP D 157
 None
 0.88A 3iv6C-1qgeD:
undetectable		 3iv6C-1qgeD:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00557
(Peptidase_M24) 		3 SER A  95
ASP A  93
ASP A  59
 M2C  A3001 ( 3.8A)
CO  A1002 ( 1.8A)
None
 0.86A 3iv6C-1qxyA:
undetectable		 3iv6C-1qxyA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdn GLUTAMINE BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		3 SER A 193
ASP A  80
ASP A  63
 None
 0.75A 3iv6C-1wdnA:
undetectable		 3iv6C-1wdnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		3 SER A 294
ASP A 135
ASP A 298
 None
 0.69A 3iv6C-1xe4A:
undetectable		 3iv6C-1xe4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjm POLYNUCLEOTIDE
5'-HYDROXYL-KINASE

(Mus musculus) 		no annotation 3 SER A  86
ASP A  91
ASP A  56
 None
 0.77A 3iv6C-1yjmA:
undetectable		 3iv6C-1yjmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zeq CATION EFFLUX SYSTEM
PROTEIN CUSF

(Escherichia
coli) 		PF11604
(CusF_Ec) 		3 SER X  60
ASP X  83
ASP X  66
 None
 0.72A 3iv6C-1zeqX:
undetectable		 3iv6C-1zeqX:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 SER A 418
ASP A 320
ASP A 422
 PIB  A3632 (-2.5A)
None
PIB  A3632 (-3.6A)
 0.92A 3iv6C-1zsqA:
undetectable		 3iv6C-1zsqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		3 SER A  37
ASP A  41
ASP A  70
 None
 0.86A 3iv6C-2a9vA:
2.2		 3iv6C-2a9vA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		3 SER A 778
ASP A 678
ASP A 781
 None
 0.95A 3iv6C-2b3xA:
undetectable		 3iv6C-2b3xA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 SER A 159
ASP A 164
ASP A 272
 None
 0.92A 3iv6C-2c5aA:
5.1		 3iv6C-2c5aA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 SER A 233
ASP A 238
ASP A 269
 None
None
MG  A 602 (-3.7A)
 0.93A 3iv6C-2f43A:
undetectable		 3iv6C-2f43A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		3 SER A  14
ASP A  18
ASP A 179
 None
 0.86A 3iv6C-2g5xA:
undetectable		 3iv6C-2g5xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		3 SER A 348
ASP A 352
ASP A 405
 None
 0.94A 3iv6C-2h1nA:
undetectable		 3iv6C-2h1nA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnu EDB

(Homo sapiens) 		PF00041
(fn3) 		3 SER A  21
ASP A  19
ASP A  16
 None
 0.72A 3iv6C-2mnuA:
undetectable		 3iv6C-2mnuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7d PROTEIN DDI1 HOMOLOG
2

(Homo sapiens) 		PF00240
(ubiquitin) 		3 SER A 163
ASP A 124
ASP A 156
 None
 0.77A 3iv6C-2n7dA:
undetectable		 3iv6C-2n7dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 SER A 301
ASP A 253
ASP A 424
 None
TLA  A 528 (-4.1A)
None
 0.86A 3iv6C-2pyxA:
undetectable		 3iv6C-2pyxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		3 SER A 276
ASP A 152
ASP A 294
 None
FAD  A 500 (-4.9A)
None
 0.86A 3iv6C-2qa1A:
2.9		 3iv6C-2qa1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		3 SER A 276
ASP A 152
ASP A 294
 None
FAD  A 500 (-4.8A)
None
 0.81A 3iv6C-2qa2A:
undetectable		 3iv6C-2qa2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcq BONE MORPHOGENETIC
PROTEIN 3

(Homo sapiens) 		PF00019
(TGF_beta) 		3 SER A  31
ASP A  33
ASP A  19
 None
 0.93A 3iv6C-2qcqA:
undetectable		 3iv6C-2qcqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 SER D 287
ASP D 239
ASP D 125
 None
 0.92A 3iv6C-2qe7D:
2.7		 3iv6C-2qe7D:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7l AGGLUTININ-LIKE ALS9
PROTEIN

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		3 SER A 124
ASP A 259
ASP A 130
 None
 0.83A 3iv6C-2y7lA:
undetectable		 3iv6C-2y7lA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		3 SER A 337
ASP A 238
ASP A 341
 SO4  A1506 (-4.3A)
None
SO4  A1506 (-4.3A)
 0.93A 3iv6C-2yf0A:
undetectable		 3iv6C-2yf0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 SER B 180
ASP B 177
ASP B 134
 None
 0.81A 3iv6C-3a79B:
undetectable		 3iv6C-3a79B:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		3 SER A 252
ASP A 202
ASP A 207
 None
 0.65A 3iv6C-3b59A:
undetectable		 3iv6C-3b59A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bow CALPASTATIN

(Rattus
norvegicus) 		PF00748
(Calpain_inhib) 		3 SER C 657
ASP C 654
ASP C 661
 None
 0.85A 3iv6C-3bowC:
undetectable		 3iv6C-3bowC:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		3 SER A 250
ASP A  34
ASP A 254
 None
ZN  A 601 ( 4.6A)
None
 0.79A 3iv6C-3c9fA:
undetectable		 3iv6C-3c9fA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 3 SER A 166
ASP A 104
ASP A 173
 None
 0.84A 3iv6C-3cv3A:
3.4		 3iv6C-3cv3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		3 SER A  79
ASP A  59
ASP A  86
 None
EDO  A 622 (-4.6A)
None
 0.85A 3iv6C-3e2dA:
2.1		 3iv6C-3e2dA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e58 PUTATIVE
BETA-PHOSPHOGLUCOMUT
ASE

(Streptococcus
thermophilus) 		PF13419
(HAD_2) 		3 SER A 110
ASP A   8
ASP A 115
 SO4  A 301 ( 4.6A)
None
None
 0.90A 3iv6C-3e58A:
2.9		 3iv6C-3e58A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		3 SER A  11
ASP A  32
ASP A 265
 FAD  A 298 (-2.6A)
FAD  A 298 (-3.0A)
FAD  A 298 (-3.0A)
 0.74A 3iv6C-3fbsA:
undetectable		 3iv6C-3fbsA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		3 SER A 129
ASP A 174
ASP A 123
 None
 0.79A 3iv6C-3h6eA:
undetectable		 3iv6C-3h6eA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3g N-ACETYLTRANSFERASE

(Trypanosoma
brucei) 		PF00583
(Acetyltransf_1) 		3 SER A  19
ASP A  16
ASP A  91
 None
 0.93A 3iv6C-3i3gA:
undetectable		 3iv6C-3i3gA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 3 SER A  52
ASP A  71
ASP A 114
 SAM  A 301 (-2.6A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
 0.11A 3iv6C-3iv6A:
44.6		 3iv6C-3iv6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		3 SER A 179
ASP A 181
ASP A 156
 None
 0.77A 3iv6C-3kd8A:
undetectable		 3iv6C-3kd8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		3 SER A 270
ASP A 266
ASP A 214
 GOL  A 312 (-3.6A)
GOL  A 312 (-2.9A)
None
 0.64A 3iv6C-3m9uA:
undetectable		 3iv6C-3m9uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 SER A 441
ASP A 483
ASP A 444
 None
 0.76A 3iv6C-3mcaA:
undetectable		 3iv6C-3mcaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkv PUTATIVE
AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 SER A 135
ASP A 170
ASP A 203
 None
 0.82A 3iv6C-3mkvA:
undetectable		 3iv6C-3mkvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvp TETR/ACRR
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
mutans) 		PF00440
(TetR_N) 		3 SER A  95
ASP A  92
ASP A 100
 None
 0.88A 3iv6C-3mvpA:
undetectable		 3iv6C-3mvpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 140
ASP A 149
ASP A 196
 None
None
MG  A 378 ( 4.2A)
 0.61A 3iv6C-3my9A:
undetectable		 3iv6C-3my9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		3 SER A1049
ASP A1061
ASP A1099
 None
 0.87A 3iv6C-3oaiA:
undetectable		 3iv6C-3oaiA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A   9
ASP A  32
ASP A 277
 FAD  A 500 (-2.5A)
FAD  A 500 (-2.9A)
FAD  A 500 (-3.0A)
 0.75A 3iv6C-3oc4A:
undetectable		 3iv6C-3oc4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oj1 DEHALOPEROXIDASE A

(Amphitrite
ornata) 		PF00042
(Globin) 		3 SER A 119
ASP A   5
ASP A  72
 SO4  A 195 ( 4.6A)
None
None
 0.94A 3iv6C-3oj1A:
undetectable		 3iv6C-3oj1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 SER A  97
ASP A  66
ASP A  49
 None
 0.91A 3iv6C-3r0sA:
undetectable		 3iv6C-3r0sA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk6 RUVB-LIKE 2

(Homo sapiens) 		PF06068
(TIP49) 		3 SER A 310
ASP A 349
ASP A 305
 None
 0.91A 3iv6C-3uk6A:
undetectable		 3iv6C-3uk6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		3 SER A 283
ASP A 274
ASP A 258
 None
 0.87A 3iv6C-3vmnA:
undetectable		 3iv6C-3vmnA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 SER A 217
ASP A 164
ASP A 168
 None
 0.90A 3iv6C-3w5nA:
undetectable		 3iv6C-3w5nA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		3 SER A 486
ASP A 421
ASP A 491
 None
 0.52A 3iv6C-3zdpA:
undetectable		 3iv6C-3zdpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyp CIP1

(Trichoderma
reesei) 		no annotation 3 SER A   8
ASP A   5
ASP A  11
 None
 0.76A 3iv6C-3zypA:
undetectable		 3iv6C-3zypA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdg NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 SER C  75
ASP C  95
ASP C 122
 None
 0.93A 3iv6C-4cdgC:
undetectable		 3iv6C-4cdgC:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4che POLYMERASE BASIC
PROTEIN 2

(Thogoto
thogotovirus) 		no annotation 3 SER A 332
ASP A 409
ASP A 377
 None
 0.88A 3iv6C-4cheA:
undetectable		 3iv6C-4cheA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI) 		3 SER C  55
ASP C  43
ASP C  50
 None
 0.87A 3iv6C-4d10C:
undetectable		 3iv6C-4d10C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER H 493
ASP H 491
ASP H 496
 None
 0.93A 3iv6C-4fxgH:
undetectable		 3iv6C-4fxgH:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Paraburkholderia
phymatum) 		PF04166
(PdxA) 		3 SER A 327
ASP A 324
ASP A 310
 None
 0.67A 3iv6C-4jqpA:
2.4		 3iv6C-4jqpA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8t UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF01843
(DIL) 		3 SER A1599
ASP A1677
ASP A1596
 None
 0.71A 3iv6C-4l8tA:
undetectable		 3iv6C-4l8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leb AGGLUTININ-LIKE
PROTEIN 3

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		3 SER A 124
ASP A 260
ASP A 130
 None
 0.85A 3iv6C-4lebA:
undetectable		 3iv6C-4lebA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nte DEPH

(Chromobacterium
violaceum) 		PF07992
(Pyr_redox_2) 		3 SER A  14
ASP A  35
ASP A 268
 FAD  A 301 (-2.6A)
FAD  A 301 (-3.0A)
FAD  A 301 (-2.9A)
 0.73A 3iv6C-4nteA:
3.5		 3iv6C-4nteA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 SER A 462
ASP A 275
ASP A 456
 None
 0.87A 3iv6C-4uzsA:
undetectable		 3iv6C-4uzsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		3 SER A 176
ASP A 423
ASP A 209
 None
 0.87A 3iv6C-4wj3A:
undetectable		 3iv6C-4wj3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		3 SER A 184
ASP A 217
ASP A 117
 None
 0.76A 3iv6C-4wzzA:
2.6		 3iv6C-4wzzA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		3 SER A 545
ASP A 674
ASP A 548
 None
 0.84A 3iv6C-4xjxA:
undetectable		 3iv6C-4xjxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrp HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
cruzi) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 SER A 150
ASP A  88
ASP A 174
 None
None
HIS  A 501 (-2.9A)
 0.94A 3iv6C-4yrpA:
undetectable		 3iv6C-4yrpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 SER A 661
ASP A 657
ASP A 492
 None
 0.37A 3iv6C-5a3fA:
undetectable		 3iv6C-5a3fA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 SER A 860
ASP A 813
ASP A 843
 None
 0.81A 3iv6C-5a55A:
undetectable		 3iv6C-5a55A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 SER A  38
ASP A  35
ASP A 191
 None
SF4  A 503 (-2.2A)
None
 0.93A 3iv6C-5aa5A:
undetectable		 3iv6C-5aa5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boi GERMINATION PROTEIN
YPEB

(Bacillus
megaterium) 		PF03413
(PepSY)
PF14620
(YPEB) 		3 SER A 359
ASP A 362
ASP A 270
 None
 0.92A 3iv6C-5boiA:
undetectable		 3iv6C-5boiA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bty LPG1496

(Legionella
pneumophila) 		no annotation 3 SER A 193
ASP A 189
ASP A 241
 None
 0.59A 3iv6C-5btyA:
undetectable		 3iv6C-5btyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvi INTERFERON
REGULATORY FACTOR 4

(Mus musculus) 		PF10401
(IRF-3) 		3 SER A 285
ASP A 283
ASP A 288
 CL  A 503 (-4.7A)
None
None
 0.94A 3iv6C-5bviA:
undetectable		 3iv6C-5bviA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chh ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF12625
(Arabinose_bd)
PF12833
(HTH_18) 		3 SER A 110
ASP A 116
ASP A 113
 None
 0.83A 3iv6C-5chhA:
undetectable		 3iv6C-5chhA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds8 FAB HPU98 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER A  96
ASP A 101
ASP A  98
 None
 0.87A 3iv6C-5ds8A:
undetectable		 3iv6C-5ds8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guf CDP-ARCHAEOL
SYNTHASE

(Aeropyrum
pernix) 		no annotation 3 SER A 104
ASP A 100
ASP A  41
 CTP  A 201 (-2.3A)
CTP  A 201 ( 3.4A)
None
 0.85A 3iv6C-5gufA:
undetectable		 3iv6C-5gufA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 3 SER B 622
ASP B 630
ASP B 110
 None
 0.92A 3iv6C-5iz5B:
undetectable		 3iv6C-5iz5B:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1

(Homo sapiens;
Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set)
PF13895
(Ig_2) 		3 SER D  87
ASP D  89
ASP A 196
 None
 0.73A 3iv6C-5knmD:
undetectable		 3iv6C-5knmD:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 3 SER A 122
ASP A 124
ASP A 228
 None
 0.86A 3iv6C-5m0kA:
undetectable		 3iv6C-5m0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n48 FIBRONECTIN

(Homo sapiens) 		no annotation 3 SER B1282
ASP B1280
ASP B1277
 None
 0.92A 3iv6C-5n48B:
undetectable		 3iv6C-5n48B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 3 SER B 624
ASP B 626
ASP B 677
 None
 0.84A 3iv6C-5swiB:
undetectable		 3iv6C-5swiB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szr PROTEIN PCDHGB2

(Mus musculus) 		PF00028
(Cadherin) 		3 SER A 458
ASP A 480
ASP A 506
 None
None
CA  A 712 (-3.5A)
 0.88A 3iv6C-5szrA:
undetectable		 3iv6C-5szrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u64 VHH-28

(Camelus
dromedarius) 		PF07686
(V-set) 		3 SER B 101
ASP B  95
ASP B   1
 None
 0.88A 3iv6C-5u64B:
undetectable		 3iv6C-5u64B:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Leishmania
donovani) 		PF00579
(tRNA-synt_1b) 		3 SER A 314
ASP A 311
ASP A 294
 None
 0.87A 3iv6C-5usfA:
1.4		 3iv6C-5usfA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 3 SER B2621
ASP B 756
ASP B 770
 None
 0.73A 3iv6C-5wfcB:
undetectable		 3iv6C-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whg PROTEIN VMS1

(Saccharomyces
cerevisiae) 		no annotation 3 SER A 318
ASP A 350
ASP A 323
 None
 0.90A 3iv6C-5whgA:
undetectable		 3iv6C-5whgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 3 SER A 300
ASP A 547
ASP A 123
 None
 0.82A 3iv6C-5x9wA:
undetectable		 3iv6C-5x9wA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1

(Zygosaccharomyces
rouxii) 		no annotation 3 SER A 280
ASP A 220
ASP A 302
 None
 0.80A 3iv6C-5yk7A:
undetectable		 3iv6C-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 3 SER A  94
ASP A 159
ASP A  91
 None
 0.93A 3iv6C-6aneA:
undetectable		 3iv6C-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 3 SER A 394
ASP A 361
ASP A 399
 None
 0.76A 3iv6C-6aunA:
undetectable		 3iv6C-6aunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b20 GUANINE
NUCLEOTIDE-BINDING
PROTEIN
G(I)/G(S)/G(T)
SUBUNIT BETA-1

(Bos taurus) 		no annotation 3 SER A 265
ASP A 267
ASP A 247
 None
 0.90A 3iv6C-6b20A:
undetectable		 3iv6C-6b20A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 3 SER A 277
ASP A 137
ASP A 285
 None
 0.63A 3iv6C-6begA:
undetectable		 3iv6C-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 SER A 803
ASP A 798
ASP A 935
 None
 0.95A 3iv6C-6bf6A:
undetectable		 3iv6C-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 SER A 194
ASP A 198
ASP A 225
 None
 0.86A 3iv6C-6eonA:
undetectable		 3iv6C-6eonA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epc PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
12

(Rattus
norvegicus) 		no annotation 3 SER P  21
ASP P  25
ASP P  59
 None
 0.81A 3iv6C-6epcP:
undetectable		 3iv6C-6epcP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		3 SER B 629
ASP B 625
ASP B 614
 None
 0.82A 3iv6C-6reqB:
undetectable		 3iv6C-6reqB:
19.50