SIMILAR PATTERNS OF AMINO ACIDS FOR 3IV6_C_SAMC301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct5 PROTEIN (YEAST
HYPOTHETICAL
PROTEIN, SELENOMET)

(Saccharomyces
cerevisiae) 		PF01168
(Ala_racemase_N) 		5 ARG A 127
PRO A 136
SER A 116
ILE A 164
LEU A 177
 None
 1.21A 3iv6C-1ct5A:
undetectable		 3iv6C-1ct5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		5 PRO A 267
SER A 239
ASP A 248
ILE A 376
LEU A 286
 None
 1.26A 3iv6C-1e8tA:
undetectable		 3iv6C-1e8tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		5 GLY A 253
ASP A 274
ILE A 273
ARG A 262
LEU A 257
 None
 1.16A 3iv6C-1fp3A:
undetectable		 3iv6C-1fp3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		5 PHE A 151
GLY A 207
SER A 204
ILE A 244
ARG A 175
 None
 1.28A 3iv6C-1gq8A:
undetectable		 3iv6C-1gq8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy5 CALSEPRRP

(Calystegia
sepium) 		PF00445
(Ribonuclease_T2) 		5 PRO A  80
GLY A  39
THR A  41
ILE A 206
ARG A  33
 None
 1.18A 3iv6C-1jy5A:
undetectable		 3iv6C-1jy5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy5 CALSEPRRP

(Calystegia
sepium) 		PF00445
(Ribonuclease_T2) 		5 PRO A  80
GLY A  39
THR A  41
SER A 137
ILE A 206
 None
 1.20A 3iv6C-1jy5A:
undetectable		 3iv6C-1jy5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc0 BILIVERDIN REDUCTASE
A

(Rattus
norvegicus) 		PF01408
(GFO_IDH_MocA)
PF09166
(Biliv-reduc_cat) 		5 ARG A 150
GLY A 147
PHE A 232
SER A 236
LEU A 212
 None
 1.35A 3iv6C-1lc0A:
3.6		 3iv6C-1lc0A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuj ODORANT BINDING
PROTEIN ASP2

(Apis mellifera) 		PF01395
(PBP_GOBP) 		5 GLY A  63
ASP A 105
ILE A 109
ARG A  57
LEU A  61
 None
 1.33A 3iv6C-1tujA:
undetectable		 3iv6C-1tujA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Pyrobaculum
aerophilum) 		PF01791
(DeoC) 		5 ARG A 126
SER A 148
ILE A 137
ARG A  95
LEU A 133
 None
 1.37A 3iv6C-1vcvA:
undetectable		 3iv6C-1vcvA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 PRO A 373
GLY A 178
THR A 355
PHE A 218
ARG A 183
 None
None
PO4  A 500 (-4.1A)
None
None
 1.34A 3iv6C-1vlpA:
undetectable		 3iv6C-1vlpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 GLY B 324
THR B 364
SER B 282
ILE B 292
ARG B  34
 None
 1.31A 3iv6C-1wa5B:
undetectable		 3iv6C-1wa5B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyo MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		5 PHE A  70
GLY A  48
PHE A 118
ILE A  98
LEU A  85
 None
 1.25A 3iv6C-1wyoA:
undetectable		 3iv6C-1wyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		5 GLY A 362
THR A 489
SER A 371
ILE A 418
LEU A 334
 None
 0.84A 3iv6C-1xfuA:
undetectable		 3iv6C-1xfuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 GLY A  49
PHE A 302
SER A 303
ILE A 281
LEU A  48
 None
 1.10A 3iv6C-1yp4A:
undetectable		 3iv6C-1yp4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		5 PRO A   6
GLY A 297
SER A 301
ILE A 312
LEU A 330
 None
 1.11A 3iv6C-1ypxA:
undetectable		 3iv6C-1ypxA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ziq GAMMA CRYSTALLIN E

(Rattus
norvegicus) 		PF00030
(Crystall) 		5 ARG A1139
GLY A1164
ILE A1091
ARG A1167
LEU A1166
 None
 1.19A 3iv6C-1ziqA:
undetectable		 3iv6C-1ziqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		5 PHE X 216
GLY X 193
ASP X 150
ILE X 147
LEU X 191
 None
 1.20A 3iv6C-2f5tX:
2.6		 3iv6C-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		5 PHE X 216
SER X 127
ASP X 150
ILE X 147
LEU X 191
 None
 1.26A 3iv6C-2f5tX:
2.6		 3iv6C-2f5tX:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ARG A 255
GLY A 281
THR A 287
PHE A 353
ILE A 273
 None
 1.35A 3iv6C-2g3nA:
undetectable		 3iv6C-2g3nA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		5 PRO A  84
GLY A  39
ILE A  74
ARG A  46
LEU A  44
 None
 1.15A 3iv6C-2hi1A:
undetectable		 3iv6C-2hi1A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 PRO A 202
THR A 196
SER A 288
ILE A 266
LEU A 191
 GOL  A 505 ( 4.6A)
NDP  A 400 (-3.2A)
None
None
None
 1.23A 3iv6C-2hxvA:
undetectable		 3iv6C-2hxvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		5 PHE A 181
THR A 184
ILE A 159
ARG A 143
LEU A 145
 None
 1.30A 3iv6C-2jakA:
undetectable		 3iv6C-2jakA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jli YOP PROTEINS
TRANSLOCATION
PROTEIN

(Yersinia pestis) 		PF01312
(Bac_export_2) 		5 PRO A 264
SER A 257
ILE A 326
ARG A 314
LEU A 316
 None
 1.27A 3iv6C-2jliA:
undetectable		 3iv6C-2jliA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpu RBP1

(Hordeum vulgare) 		PF00076
(RRM_1) 		5 GLY A  24
THR A  20
PHE A  29
ARG A  78
LEU A  75
 None
 1.36A 3iv6C-2mpuA:
undetectable		 3iv6C-2mpuA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ncl BOLA-LIKE PROTEIN 3

(Homo sapiens) 		PF01722
(BolA) 		5 ARG A  76
THR A  77
PHE A  44
SER A  69
ILE A  65
 None
 1.37A 3iv6C-2nclA:
undetectable		 3iv6C-2nclA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgc UNCHARACTERIZED
PROTEIN

(uncultured
marine organism) 		no annotation 5 PHE A  61
PRO A 112
GLY A 166
ILE A 134
LEU A 149
 None
 1.35A 3iv6C-2pgcA:
undetectable		 3iv6C-2pgcA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13

(Homo sapiens) 		PF01852
(START) 		5 PRO A 963
SER A1031
ASP A1051
ILE A1069
LEU A1055
 None
 1.28A 3iv6C-2psoA:
undetectable		 3iv6C-2psoA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		5 ARG A 207
GLY A 220
ILE A 241
ARG A 224
LEU A 210
 None
 1.25A 3iv6C-2qjcA:
undetectable		 3iv6C-2qjcA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  33
THR A  97
ASP A  65
ILE A  66
LEU A  51
 None
 1.37A 3iv6C-2v6bA:
5.2		 3iv6C-2v6bA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 PRO A  50
GLY A 111
ILE A  62
ARG A 276
LEU A 110
 None
 1.27A 3iv6C-2vg2A:
undetectable		 3iv6C-2vg2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 PRO D 204
GLY D 178
SER D 390
ILE D  46
LEU D 177
 None
None
None
PMR  C1414 ( 4.7A)
GOL  D1530 ( 4.6A)
 1.31A 3iv6C-2ynmD:
undetectable		 3iv6C-2ynmD:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ARG A  70
THR A  69
PHE A 130
ILE A 153
LEU A 116
 None
 1.18A 3iv6C-2z0mA:
3.0		 3iv6C-2z0mA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A  69
PHE A 130
SER A  59
ILE A 153
LEU A 116
 None
 1.25A 3iv6C-2z0mA:
3.0		 3iv6C-2z0mA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		5 GLY A  98
THR A 104
PHE A 237
ARG A 101
LEU A  99
 None
 1.19A 3iv6C-2zq5A:
undetectable		 3iv6C-2zq5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0v SENSOR PROTEIN

(Thermotoga
maritima) 		PF00989
(PAS) 		5 GLY A 469
SER A 474
ILE A 514
ARG A 435
LEU A 430
 None
None
None
None
EOH  A 101 ( 4.4A)
 1.37A 3iv6C-3a0vA:
undetectable		 3iv6C-3a0vA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 195
ASP A 162
ILE A 163
ARG A 176
LEU A 177
 None
None
None
SO4  A2003 (-3.1A)
None
 1.35A 3iv6C-3aczA:
2.3		 3iv6C-3aczA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 PRO B 191
GLY B 165
SER B 374
ILE B  46
LEU B 164
 None
 1.30A 3iv6C-3aeqB:
3.1		 3iv6C-3aeqB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbh NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Staphylococcus
epidermidis) 		PF00881
(Nitroreductase) 		5 PHE A  23
THR A 160
ASP A  35
ILE A  38
LEU A  85
 None
 1.25A 3iv6C-3gbhA:
undetectable		 3iv6C-3gbhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		5 PRO J  64
THR C  54
ASP C 121
ILE C 117
LEU C 148
 None
 1.36A 3iv6C-3h0gJ:
undetectable		 3iv6C-3h0gJ:
14.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 12 TRP A  11
PHE A  18
ARG A  27
PRO A  28
GLY A  50
THR A  53
PHE A  72
SER A  73
ASP A  95
ILE A  96
ARG A 115
LEU A 116
 SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
None
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 4.7A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.5A)
None
SAM  A 301 (-4.2A)
 0.26A 3iv6C-3iv6A:
44.6		 3iv6C-3iv6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 5 TRP A 204
PHE A  18
ARG A  27
PRO A  28
ARG A 115
 None
SAM  A 301 (-3.7A)
None
SAM  A 301 ( 4.8A)
None
 1.21A 3iv6C-3iv6A:
44.6		 3iv6C-3iv6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 GLY A 401
PHE A 380
SER A 397
ILE A 359
LEU A 402
 None
 1.35A 3iv6C-3k28A:
undetectable		 3iv6C-3k28A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Corynebacterium
glutamicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 GLY A 285
THR A 289
ILE A 238
ARG A  77
LEU A  79
 None
 1.29A 3iv6C-3m1gA:
undetectable		 3iv6C-3m1gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 512
PRO A  84
THR A  86
ILE A  50
LEU A  59
 FAY  A 600 (-3.6A)
None
FAY  A 600 (-4.4A)
None
None
 1.17A 3iv6C-3q9tA:
2.0		 3iv6C-3q9tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		5 PHE A 216
GLY A 193
ASP A 150
ILE A 147
LEU A 191
 None
None
ACT  A 402 (-4.0A)
None
None
 1.17A 3iv6C-3qphA:
undetectable		 3iv6C-3qphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		5 ARG A 340
GLY A 107
ASP A 323
ILE A 300
LEU A  61
 None
 1.28A 3iv6C-3t7vA:
undetectable		 3iv6C-3t7vA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 GLY A 309
THR A 350
SER A 267
ILE A 277
ARG A  27
 None
 1.34A 3iv6C-4b8jA:
undetectable		 3iv6C-4b8jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		5 ARG A   8
THR A  43
ASP A  56
ILE A  73
LEU A 114
 None
 1.36A 3iv6C-4dpyA:
undetectable		 3iv6C-4dpyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 THR A 362
SER A 342
ASP A 470
ILE A 517
LEU A 367
 None
 1.31A 3iv6C-4fffA:
undetectable		 3iv6C-4fffA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		5 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.01A 3iv6C-4issA:
undetectable		 3iv6C-4issA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		6 TRP A  14
GLY A  59
PHE A  81
ASP A 105
ARG A 153
LEU A 124
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.6A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
None
 0.90A 3iv6C-4krgA:
16.9		 3iv6C-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 TRP A  14
GLY A  61
PHE A  81
ASP A 105
ARG A 153
 SAH  A 502 (-3.8A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
None
 1.24A 3iv6C-4krgA:
16.9		 3iv6C-4krgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1q L-LACTATE
DEHYDROGENASE

([Bacillus]
selenitireducens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 171
THR A 151
SER A 186
ILE A 190
LEU A 158
 None
 1.26A 3iv6C-4m1qA:
4.3		 3iv6C-4m1qA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdc PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Sinorhizobium
meliloti) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		5 ARG A 215
GLY A 185
ILE A 145
ARG A  14
LEU A 181
 None
 1.32A 3iv6C-4mdcA:
undetectable		 3iv6C-4mdcA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PRO A 236
GLY A 185
PHE A 199
ILE A 206
LEU A 220
 None
 1.17A 3iv6C-4mewA:
undetectable		 3iv6C-4mewA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjk CRISPR PROTEIN

(Archaeoglobus
fulgidus) 		PF09704
(Cas_Cas5d) 		5 PRO A  78
GLY A 114
THR A 116
SER A 110
ILE A  18
 None
 1.29A 3iv6C-4mjkA:
undetectable		 3iv6C-4mjkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  33
THR A  97
ASP A  65
ILE A  66
LEU A  51
 None
 1.36A 3iv6C-4nd4A:
4.8		 3iv6C-4nd4A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		5 ARG A  37
PRO A  36
THR A  58
ILE A  84
LEU A  98
 None
 1.36A 3iv6C-4nzjA:
undetectable		 3iv6C-4nzjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		5 PHE A 163
GLY A  12
SER A  36
ASP A 118
ILE A 116
 None
FDA  A 501 (-3.1A)
FDA  A 501 (-3.1A)
None
None
 1.19A 3iv6C-4opuA:
2.5		 3iv6C-4opuA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		5 PHE A 280
ARG A 283
GLY A 342
ASP A 335
LEU A 344
 None
 1.34A 3iv6C-4p3zA:
undetectable		 3iv6C-4p3zA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE

(Lactobacillus
jensenii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 THR A 212
PHE A 221
ILE A 202
ARG A 235
LEU A 204
 None
 0.92A 3iv6C-4prkA:
5.1		 3iv6C-4prkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pts GLUTATHIONE
S-TRANSFERASE

(Gordonia
bronchialis) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 GLY A 274
THR A 278
ILE A 227
ARG A  66
LEU A  68
 None
 1.33A 3iv6C-4ptsA:
undetectable		 3iv6C-4ptsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP2
COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C;
Enterovirus C) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 PHE 3 208
GLY 2 120
SER 3 122
ILE 2 246
LEU 2 236
 None
 1.20A 3iv6C-4q4y3:
undetectable		 3iv6C-4q4y3:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 TRP A 323
GLY A 340
THR A 338
ILE A 212
ARG A 346
 None
None
None
LLP  A  34 ( 3.9A)
None
 1.27A 3iv6C-4qhrA:
undetectable		 3iv6C-4qhrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG

(Homo sapiens) 		PF00515
(TPR_1)
PF12895
(ANAPC3)
PF13181
(TPR_8) 		5 TRP A 149
ARG A 473
THR A 167
SER A 150
ILE A 158
 None
 1.33A 3iv6C-4rg6A:
undetectable		 3iv6C-4rg6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk2 ALDO/KETO REDUCTASE

(Polaromonas sp.
JS666) 		PF00248
(Aldo_ket_red) 		5 THR A  86
PHE A  18
ILE A  45
ARG A 116
LEU A  71
 None
 1.22A 3iv6C-4xk2A:
undetectable		 3iv6C-4xk2A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 GLY A  94
THR A 118
ASP A  49
ILE A  48
LEU A  98
 NAG  A 701 ( 3.7A)
NAG  A 701 (-4.4A)
None
None
None
 1.29A 3iv6C-4z61A:
undetectable		 3iv6C-4z61A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT
HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis;
Candidatus
Kuenenia
stuttgartiensis) 		no annotation
PF02239
(Cytochrom_D1) 		5 ARG B 336
PRO B 279
GLY A 593
ILE A 299
LEU B 283
 BET  B 403 (-4.3A)
None
None
None
None
 1.09A 3iv6C-5c2vB:
undetectable		 3iv6C-5c2vB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Brucella ovis) 		PF13420
(Acetyltransf_4) 		5 PHE A  52
PRO A 177
SER A  85
ARG A  79
LEU A  81
 None
 1.32A 3iv6C-5dwmA:
undetectable		 3iv6C-5dwmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2c XAA-PRO DIPEPTIDASE

(Mycobacterium
tuberculosis) 		PF01321
(Creatinase_N) 		5 ARG A  31
SER A 125
ILE A  14
ARG A   6
LEU A  10
 None
 1.08A 3iv6C-5e2cA:
undetectable		 3iv6C-5e2cA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evm FUSION GLYCOPROTEIN
F0

(Nipah
henipavirus) 		PF00523
(Fusion_gly) 		5 PHE A 282
PRO A  52
GLY A 264
SER A 232
ILE A 266
 None
 1.36A 3iv6C-5evmA:
undetectable		 3iv6C-5evmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftf TPR DOMAIN PROTEIN

(Bacteroides sp.
3_1_23) 		PF05970
(PIF1) 		5 ARG A 175
PRO A 131
GLY A 429
THR A 176
ILE A 180
 None
 1.37A 3iv6C-5ftfA:
undetectable		 3iv6C-5ftfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6

(Homo sapiens) 		PF07571
(TAF6_C) 		5 ARG J 373
PRO J 369
THR J 371
ARG J 315
LEU J 317
 None
 1.36A 3iv6C-5furJ:
undetectable		 3iv6C-5furJ:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 PRO A 218
GLY A 355
PHE A 360
SER A 240
ASP A 361
 None
None
None
None
SGN  A1522 (-2.8A)
 1.36A 3iv6C-5g2vA:
undetectable		 3iv6C-5g2vA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 5 PHE A 236
GLY A  64
PHE A 232
SER A 233
ILE A  35
 None
 1.18A 3iv6C-5gmtA:
undetectable		 3iv6C-5gmtA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gru DIABODY PROTEIN
DIABODY PROTEIN

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		5 TRP L  48
GLY H 225
THR H 227
PHE L 103
ILE L 101
 TRP  L  48 ( 0.5A)
GLY  H 225 ( 0.0A)
THR  H 227 ( 0.8A)
PHE  L 103 ( 1.3A)
ILE  L 101 ( 0.7A)
 1.28A 3iv6C-5gruL:
undetectable		 3iv6C-5gruL:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 ARG A 218
SER A 267
ASP A 301
ILE A 304
LEU A 308
 None
 1.35A 3iv6C-5hs1A:
undetectable		 3iv6C-5hs1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.01A 3iv6C-5i8iA:
3.2		 3iv6C-5i8iA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 204
THR A 123
SER A 298
ILE A 233
LEU A 208
 None
 1.28A 3iv6C-5iq0A:
2.7		 3iv6C-5iq0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		5 ARG A 267
THR A 268
ASP A 322
ILE A 362
LEU A 365
 None
 1.30A 3iv6C-5jxmA:
undetectable		 3iv6C-5jxmA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		5 ARG C  20
PHE C 389
ILE C 297
ARG C 368
LEU C 383
 None
 1.32A 3iv6C-5k1cC:
undetectable		 3iv6C-5k1cC:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE B 388
PRO B 373
GLY B 767
PHE B 320
LEU B 766
 None
 1.34A 3iv6C-5kyuB:
undetectable		 3iv6C-5kyuB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t77 PUTATIVE LIPID II
FLIPPASE MURJ

(Thermosipho
africanus) 		PF03023
(MVIN) 		5 PHE A 184
THR A 181
PHE A 109
ILE A 106
LEU A 125
 None
 1.37A 3iv6C-5t77A:
undetectable		 3iv6C-5t77A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 TRP A 279
PRO A 385
GLY A 308
ILE A 153
LEU A 312
 None
 1.19A 3iv6C-5tufA:
2.7		 3iv6C-5tufA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 TRP A 279
PRO A 383
GLY A 308
ILE A 153
LEU A 312
 None
 1.22A 3iv6C-5tulA:
undetectable		 3iv6C-5tulA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 5 GLY A  33
SER A 181
ILE A 231
ARG A 147
LEU A  32
 None
 1.35A 3iv6C-5txfA:
undetectable		 3iv6C-5txfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlq LOC100158544 PROTEIN

(Xenopus
tropicalis) 		PF03133
(TTL) 		5 PHE A 382
PRO A 448
PHE A 514
ILE A 475
LEU A 458
 None
 1.10A 3iv6C-5vlqA:
undetectable		 3iv6C-5vlqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ARG A 243
THR A 186
ILE A 134
ARG A 183
LEU A 150
 None
 1.28A 3iv6C-5vpuA:
4.7		 3iv6C-5vpuA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		5 TRP A 213
PHE A 221
PRO A 232
SER A 214
LEU A 235
 None
 1.04A 3iv6C-5vysA:
4.4		 3iv6C-5vysA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 5 GLY A 213
THR A 157
SER A 282
ILE A 363
LEU A 287
 None
 1.27A 3iv6C-5wkaA:
undetectable		 3iv6C-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 6 TRP A  16
GLY A  61
PHE A  83
ASP A 107
ARG A 157
LEU A 128
 SAH  A 701 (-3.8A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
None
None
 0.85A 3iv6C-5wp4A:
17.7		 3iv6C-5wp4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 6 TRP A  16
GLY A  61
PHE A  83
ASP A 107
ARG A 157
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
None
None
 0.87A 3iv6C-5wp5A:
17.7		 3iv6C-5wp5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zt3 WA352

(Oryza sativa) 		no annotation 5 ARG A  88
GLY A  92
THR A  89
ILE A  30
ARG A  98
 None
 1.16A 3iv6C-5zt3A:
undetectable		 3iv6C-5zt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 5 PHE C 191
THR C 154
SER C 149
ILE C  91
LEU C  19
 None
 1.33A 3iv6C-6c4mC:
3.2		 3iv6C-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 PRO N  24
GLY J 142
SER N 102
ASP J 126
ILE J  95
 None
 1.28A 3iv6C-6cfwN:
undetectable		 3iv6C-6cfwN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cph TCR BETA CHAIN

(Homo sapiens) 		no annotation 5 PHE E  56
ARG E  80
PRO E  81
THR E  88
ASP E  73
 None
 1.34A 3iv6C-6cphE:
undetectable		 3iv6C-6cphE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cph TCR BETA CHAIN

(Homo sapiens) 		no annotation 5 PHE E  56
ARG E  80
PRO E  81
THR E  88
ASP E  74
 None
 1.22A 3iv6C-6cphE:
undetectable		 3iv6C-6cphE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 5 ARG A 262
GLY A  51
SER A 399
ILE A 247
LEU A  47
 None
 0.98A 3iv6C-6dk2A:
undetectable		 3iv6C-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 PRO A  83
GLY A  38
ILE A  73
ARG A  45
LEU A  43
 None
 1.08A 3iv6C-6e85A:
undetectable		 3iv6C-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 GLY A 525
SER A 528
ILE A 508
ARG A 550
LEU A 523
 None
 1.15A 3iv6C-6g9oA:
undetectable		 3iv6C-6g9oA:
undetectable